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Cheap flights from Key West to Panama City from $288

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Panama City departing on 5/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Key West to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:15 pm - 11:30 pm
EYW
-
ECP
6h 15m
1 stop
Delta Logo
1:57 pm - 7:54 pm
ECP
-
EYW
4h 57m
1 stop
$393Delta
Wed, Aug 19 - Sun, Aug 23
Delta Logo
6:19 pm - 11:28 pm
EYW
-
ECP
6h 09m
1 stop
Delta Logo
6:00 am - 12:27 pm
ECP
-
EYW
5h 27m
1 stop
$447Delta
Thu, May 14 - Mon, May 18
American Airlines Logo
3:58 pm - 11:46 pm
EYW
-
ECP
8h 48m
2 stops
American Airlines Logo
7:21 am - 1:21 pm
ECP
-
EYW
5h 00m
1 stop
$452American Airlines
Thu, May 14 - Mon, May 18
American Airlines Logo
3:58 pm - 11:46 pm
EYW
-
ECP
8h 48m
2 stops
American Airlines Logo
7:21 am - 4:30 pm
ECP
-
EYW
8h 09m
2 stops
$457American Airlines
Thu, May 14 - Mon, May 18
Delta Logo
6:19 pm - 10:51 pm
EYW
-
ECP
5h 32m
1 stop
Delta Logo
11:49 am - 7:49 pm
ECP
-
EYW
7h 00m
1 stop
$473Delta
Sat, May 16 - Wed, May 20
American Airlines Logo
4:53 pm - 11:46 pm
EYW
-
ECP
7h 53m
1 stop
American Airlines Logo
10:50 am - 10:58 pm
ECP
-
EYW
11h 08m
2 stops
$512American Airlines
Sat, May 16 - Wed, May 20
American Airlines Logo
1:49 pm - 10:40 pm
EYW
-
ECP
9h 51m
2 stops
American Airlines Logo
11:04 am - 6:44 pm
ECP
-
EYW
6h 40m
1 stop
$548American Airlines
Wed, Aug 19 - Sun, Aug 23
American Airlines Logo
1:49 pm - 10:40 pm
EYW
-
ECP
9h 51m
2 stops
American Airlines Logo
7:10 am - 7:39 pm
ECP
-
EYW
11h 29m
2 stops
$607American Airlines
Wed, Aug 19 - Sun, Aug 23
American Airlines Logo
3:58 pm - 11:46 pm
EYW
-
ECP
8h 48m
2 stops
American Airlines Logo
10:50 am - 10:58 pm
ECP
-
EYW
11h 08m
2 stops
$628American Airlines
Sat, May 16 - Wed, May 20
United Airlines Logo
4:47 pm - 9:44 am
EYW
-
ECP
17h 57m
2 stops
United Airlines Logo
2:14 pm - 1:45 pm
ECP
-
EYW
22h 31m
3 stops
$1,089United Airlines
Thu, May 14 - Mon, May 18

Delta flights from Key West to Panama City, Florida

Our best Delta deals on Key West to Panama City, Florida flight tickets
Delta
Aug 19
EYW6:15 pmKey West
6h 15m
1 stop
ECP11:30 pmPanama City NW Florida Beaches
Aug 23
ECP1:57 pmPanama City NW Florida Beaches
4h 57m
1 stop
EYW7:54 pmKey West
$393
Delta
May 14
EYW6:19 pmKey West
6h 09m
1 stop
ECP11:28 pmPanama City NW Florida Beaches
May 18
ECP6:00 amPanama City NW Florida Beaches
5h 27m
1 stop
EYW12:27 pmKey West
$447
Delta
May 16
EYW6:19 pmKey West
5h 32m
1 stop
ECP10:51 pmPanama City NW Florida Beaches
May 20
ECP11:49 amPanama City NW Florida Beaches
7h 00m
1 stop
EYW7:49 pmKey West
$473

American Airlines flights from Key West to Panama City, Florida

Our best American Airlines deals on Key West to Panama City, Florida flight tickets
American Airlines
May 14
EYW3:58 pmKey West
8h 48m
2 stops
ECP11:46 pmPanama City NW Florida Beaches
May 18
ECP7:21 amPanama City NW Florida Beaches
5h 00m
1 stop
EYW1:21 pmKey West
$452
American Airlines
May 14
EYW3:58 pmKey West
8h 48m
2 stops
ECP11:46 pmPanama City NW Florida Beaches
May 18
ECP7:21 amPanama City NW Florida Beaches
8h 09m
2 stops
EYW4:30 pmKey West
$457
American Airlines
May 16
EYW4:53 pmKey West
7h 53m
1 stop
ECP11:46 pmPanama City NW Florida Beaches
May 20
ECP10:50 amPanama City NW Florida Beaches
11h 08m
2 stops
EYW10:58 pmKey West
$512

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Key West to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Key WestPanama City

EYW - ECP

EYWECP

Key West

Wed 8/19

6:15 pm-11:30 pm

1 stop6h 15m

Panama City NW Florida Beaches

Sun 8/23

1:57 pm-7:54 pm

1 stop4h 57m

$393

Key WestPanama City

EYW - ECP

EYWECP

Key West

Thu 5/14

6:19 pm-11:28 pm

1 stop6h 09m

Panama City NW Florida Beaches

Mon 5/18

6:00 am-12:27 pm

1 stop5h 27m

$447

Key WestPanama City

EYW - ECP

EYWECP

Key West

Thu 5/14

3:58 pm-11:46 pm

2 stops8h 48m

Panama City NW Florida Beaches

Mon 5/18

7:21 am-1:21 pm

1 stop5h 00m

$452

Key WestPanama City

EYW - ECP

EYWECP

Key West

Thu 5/14

3:58 pm-11:46 pm

2 stops8h 48m

Panama City NW Florida Beaches

Mon 5/18

7:21 am-4:30 pm

2 stops8h 09m

$457

Key WestPanama City

EYW - ECP

EYWECP

Key West

Sat 5/16

6:19 pm-10:51 pm

1 stop5h 32m

Panama City NW Florida Beaches

Wed 5/20

11:49 am-7:49 pm

1 stop7h 00m

$473

Key WestPanama City

EYW - ECP

EYWECP

Key West

Sat 5/16

4:53 pm-11:46 pm

1 stop7h 53m

Panama City NW Florida Beaches

Wed 5/20

10:50 am-10:58 pm

2 stops11h 08m

$512

Key WestPanama City

EYW - ECP

EYWECP

Key West

Wed 8/19

1:49 pm-10:40 pm

2 stops9h 51m

Panama City NW Florida Beaches

Sun 8/23

11:04 am-6:44 pm

1 stop6h 40m

$548

Key WestPanama City

EYW - ECP

EYWECP

Key West

Wed 8/19

1:49 pm-10:40 pm

2 stops9h 51m

Panama City NW Florida Beaches

Sun 8/23

7:10 am-7:39 pm

2 stops11h 29m

$607

Key WestPanama City

EYW - ECP

EYWECP

Key West

Sat 5/16

3:58 pm-11:46 pm

2 stops8h 48m

Panama City NW Florida Beaches

Wed 5/20

10:50 am-10:58 pm

2 stops11h 08m

$628

Key WestPanama City

EYW - ECP

EYWECP

Key West

Thu 5/14

4:47 pm-9:44 am

2 stops17h 57m

Panama City NW Florida Beaches

Mon 5/18

2:14 pm-1:45 pm

3 stops22h 31m

$1,089

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Key West to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Key West to Panama City NW Florida Beaches?

Delta and American Airlines are the most popular carriers operating from Key West to Panama City NW Florida Beaches

When to book flights from Key West to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Panama City, Florida (EYW to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Panama City, Florida

Fastest flight time

5h 32m

Direct flights

None
The fastest flight from Key West to Panama City, Florida takes 5h 32m
There are no direct flights from Key West to Panama City, Florida. There are no popular flight routes from Key West to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Key West to Panama City, Florida

  • How far is Key West to Panama City NW Florida Beaches by plane?

    Panama City NW Florida Beaches is 453.5 mi away from Key West. Typically, this will take 5h 32m by plane in normal conditions.

  • When did momondo last update prices for flights from Key West Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Key West Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Key West Airport to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Key West Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Panama City?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Panama City. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Key West with this policy.

How can momondo help me find flights from Key West to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Key West. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Key West to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Key West are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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