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Cheap flights from Hyannis to South Carolina from $228

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Hyannis to South Carolina departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Hyannis to South Carolina

Cheap one-way flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:07 pm - 1:10 pm
HYA
-
CHS
49h 03m3 stops
$228Multiple Airlines
Mon, Jan 5
Multiple Airlines Logo
12:07 pm - 9:23 pm
HYA
-
CHS
33h 16m2 stops
$237Multiple Airlines
Sun, Jan 4
JetBlue Logo
7:05 am - 11:36 am
HYA
-
CHS
4h 31m1 stop
$238JetBlue
Thu, Jan 1
Multiple Airlines Logo
7:05 am - 11:57 am
HYA
-
CHS
4h 52m1 stop
$243Multiple Airlines
Sat, Jan 3
Multiple Airlines Logo
7:05 am - 9:23 pm
HYA
-
CHS
14h 18m2 stops
$259Multiple Airlines
Mon, Jan 5
JetBlue Logo
7:05 am - 12:23 pm
HYA
-
CHS
5h 18m1 stop
$278JetBlue
Sun, Jan 4
Multiple Airlines Logo
7:05 am - 10:59 pm
HYA
-
CHS
15h 54m3 stops
$283Multiple Airlines
Thu, Jan 1
JetBlue Logo
7:05 am - 11:36 am
HYA
-
CHS
4h 31m1 stop
$293JetBlue
Fri, Jan 2
Multiple Airlines Logo
7:05 am - 9:23 pm
HYA
-
CHS
38h 18m2 stops
$298Multiple Airlines
Thu, Jan 1
Multiple Airlines Logo
12:07 pm - 8:57 am
HYA
-
CHS
44h 50m2 stops
$304Multiple Airlines
Sat, Jan 3

JetBlue flights from Hyannis to South Carolina

Our best JetBlue deals on Hyannis to South Carolina flight tickets
JetBlue
Dec 23
HYA7:05 amHyannis Barnstable
4h 31m
1 stop
CHS11:36 amCharleston
Dec 30
CHS12:21 pmCharleston
4h 59m
1 stop
HYA5:20 pmHyannis Barnstable
$765
Find similar
JetBlue
Dec 23
HYA7:05 amHyannis Barnstable
4h 31m
1 stop
CHS11:36 amCharleston
Dec 29
CHS12:21 pmCharleston
4h 59m
1 stop
HYA5:20 pmHyannis Barnstable
$843
Find similar
JetBlue
Dec 22
HYA7:05 amHyannis Barnstable
4h 31m
1 stop
CHS11:36 amCharleston
Dec 29
CHS12:21 pmCharleston
4h 59m
1 stop
HYA5:20 pmHyannis Barnstable
$1,033
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Hyannis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Hyannis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Mon 1/5

12:07 pm-1:10 pm

3 stops49h 03m

$228

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sun 1/4

12:07 pm-9:23 pm

2 stops33h 16m

$237

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Thu 1/1

7:05 am-11:36 am

1 stop4h 31m

$238

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sat 1/3

7:05 am-11:57 am

1 stop4h 52m

$243

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Mon 1/5

7:05 am-9:23 pm

2 stops14h 18m

$259

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sun 1/4

7:05 am-12:23 pm

1 stop5h 18m

$278

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Thu 1/1

7:05 am-10:59 pm

3 stops15h 54m

$283

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Fri 1/2

7:05 am-11:36 am

1 stop4h 31m

$293

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Thu 1/1

7:05 am-9:23 pm

2 stops38h 18m

$298

HyannisCharleston

HYA - CHS

HYACHS

Hyannis Barnstable

Sat 1/3

12:07 pm-8:57 am

2 stops44h 50m

$304

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to South Carolina from

How to get the cheapest flight ticket from Hyannis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Hyannis Barnstable to South Carolina?

JetBlue is the most popular carrier operating from Hyannis Barnstable to South Carolina

What airlines fly to South Carolina?

Spirit Airlines, JetBlue and Delta are the top three most popular airlines that fly to South Carolina from Hyannis according to our data. Spirit Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 7 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Hyannis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Hyannis to South Carolina

Fastest flight time

4h 52m

Direct flights

None
The fastest flight from Hyannis to South Carolina takes 4h 52m
There are no direct flights from Hyannis to South Carolina. There are no popular flight routes from Hyannis to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Hyannis Barnstable Airport to South Carolina?

    Prices for flights from Hyannis Barnstable Airport to South Carolina are updated daily.

  • How old do you have to be to fly from Hyannis Barnstable Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Hyannis Barnstable Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Hyannis to South Carolina?

Finding the right flight to South Carolina from Hyannis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Hyannis to South Carolina with flexible booking policies on momondo?

All flight searches from Hyannis to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Hyannis to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Hyannis to South Carolina.

I’m not ready to book a flight from Hyannis to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Hyannis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South Carolina trip

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