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Cheap flights from Greenville, North Carolina to Des Moines from $522

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville, North Carolina to Des Moines departing on 3/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Greenville, North Carolina to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:55 pm - 9:53 pmPGV-DSM
6h 58m1 stop
American Airlines Logo
7:14 am - 2:10 pmDSM-PGV
5h 56m1 stop
$522American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
5:12 am - 12:19 pmPGV-DSM
8h 07m2 stops
American Airlines Logo
7:14 am - 2:10 pmDSM-PGV
5h 56m1 stop
$527American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
11:00 am - 7:11 pmPGV-DSM
9h 11m2 stops
American Airlines Logo
1:46 pm - 11:39 pmDSM-PGV
8h 53m2 stops
$556American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28

American Airlines flights from Greenville, North Carolina to Des Moines

Our best American Airlines deals on Greenville, North Carolina to Des Moines flight tickets
American Airlines
Mar 25
PGV3:55 pmPitt-Greenville
6h 58m
1 stop
DSM9:53 pmDes Moines
Mar 28
DSM7:14 amDes Moines
5h 56m
1 stop
PGV2:10 pmPitt-Greenville
$522
Find similar
American Airlines
Mar 25
PGV5:12 amPitt-Greenville
8h 07m
2 stops
DSM12:19 pmDes Moines
Mar 28
DSM7:14 amDes Moines
5h 56m
1 stop
PGV2:10 pmPitt-Greenville
$527
Find similar
American Airlines
Mar 25
PGV11:00 amPitt-Greenville
9h 11m
2 stops
DSM7:11 pmDes Moines
Mar 28
DSM1:46 pmDes Moines
8h 53m
2 stops
PGV11:39 pmPitt-Greenville
$556
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville, North Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Greenville, North Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleDes Moines

PGV - DSM

PGVDSM

Pitt-Greenville

Wed 3/25

3:55 pm-9:53 pm

1 stop6h 58m

Des Moines

Sat 3/28

7:14 am-2:10 pm

1 stop5h 56m

$522

GreenvilleDes Moines

PGV - DSM

PGVDSM

Pitt-Greenville

Wed 3/25

5:12 am-12:19 pm

2 stops8h 07m

Des Moines

Sat 3/28

7:14 am-2:10 pm

1 stop5h 56m

$527

GreenvilleDes Moines

PGV - DSM

PGVDSM

Pitt-Greenville

Wed 3/25

11:00 am-7:11 pm

2 stops9h 11m

Des Moines

Sat 3/28

1:46 pm-11:39 pm

2 stops8h 53m

$556

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Greenville, North Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Des Moines?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Des Moines from Greenville, North Carolina according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 4 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Greenville, North Carolina to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville, North Carolina to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville, North Carolina to Des Moines (PGV to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville, North Carolina to Des Moines

Direct flights

None
There are no direct flights from Greenville, North Carolina to Des Moines. There are no popular flight routes from Greenville, North Carolina to Des Moines.
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  • How far is Pitt-Greenville to Des Moines by plane?

    There are 967.5 mi between Pitt-Greenville and Des Moines. In terms of flight time, this usually takes a little over 6h 58m.

  • When did momondo last update prices for flights from Pitt-Greenville Airport to Des Moines Airport?

    Prices for flights from Pitt-Greenville Airport to Des Moines Airport are updated daily.

  • How old do you have to be to fly from Pitt-Greenville Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Pitt-Greenville Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Des Moines?

It is quick and easy to find Greenville to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Greenville to Des Moines with flexible booking policies on momondo?

All flight searches from Greenville to Des Moines on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Greenville to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Greenville.

I’m not ready to book a flight from Greenville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Greenville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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