Cheap flights from Florence, South Carolina to Missouri from $355

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Missouri departing on 1/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to Missouri

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:36 pm - 11:12 pm
FLO
-
STL
6h 36m1 stop
American Airlines Logo
3:54 pm - 10:43 pm
STL
-
FLO
5h 49m1 stop
$355American Airlines
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
6:15 am - 2:57 pm
FLO
-
STL
9h 42m2 stops
American Airlines Logo
3:54 pm - 10:43 pm
STL
-
FLO
5h 49m1 stop
$360American Airlines
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
6:15 am - 2:57 pm
FLO
-
STL
9h 42m2 stops
American Airlines Logo
11:37 am - 10:43 pm
STL
-
FLO
10h 06m2 stops
$365American Airlines
Fri, Jan 16 - Sun, Jan 18

American Airlines flights from Florence, South Carolina to Missouri

Our best American Airlines deals on Florence, South Carolina to Missouri flight tickets
American Airlines
Jan 16
FLO5:36 pmFlorence
6h 36m
1 stop
STL11:12 pmLambert-St Louis
Jan 18
STL3:54 pmLambert-St Louis
5h 49m
1 stop
FLO10:43 pmFlorence
American Airlines
Jan 16
FLO6:15 amFlorence
9h 42m
2 stops
STL2:57 pmLambert-St Louis
Jan 18
STL3:54 pmLambert-St Louis
5h 49m
1 stop
FLO10:43 pmFlorence
American Airlines
Jan 16
FLO6:15 amFlorence
9h 42m
2 stops
STL2:57 pmLambert-St Louis
Jan 18
STL11:37 amLambert-St Louis
10h 06m
2 stops
FLO10:43 pmFlorence

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Florence, South Carolina to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 1/16

5:36 pm-11:12 pm

1 stop6h 36m

Lambert-St Louis

Sun 1/18

3:54 pm-10:43 pm

1 stop5h 49m

$355

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 1/16

6:15 am-2:57 pm

2 stops9h 42m

Lambert-St Louis

Sun 1/18

3:54 pm-10:43 pm

1 stop5h 49m

$360

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 1/16

6:15 am-2:57 pm

2 stops9h 42m

Lambert-St Louis

Sun 1/18

11:37 am-10:43 pm

2 stops10h 06m

$365

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Florence, South Carolina to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Missouri?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Missouri from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 66% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 6 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

Cheap Florence, South Carolina to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Missouri

Fastest flight time

6h 36m

Direct flights

None
The fastest flight from Florence, South Carolina to Missouri takes 6h 36m
There are no direct flights from Florence, South Carolina to Missouri. There are no popular flight routes from Florence, South Carolina to Missouri.
  • When did momondo last update prices for flights from Florence Airport to Missouri?

    Prices for flights from Florence Airport to Missouri were last updated today.

  • How old do you have to be to fly from Florence Airport to Missouri?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Missouri?

It is quick and easy to find Florence to Missouri flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Missouri that suits you.

Can I find flights from Florence to Missouri with flexible booking policies on momondo?

Flights from Florence to Missouri with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Florence to Missouri?

Once you have performed a search for Florence to Missouri flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to Missouri right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to Missouri flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Mon 1/26
Mon 2/2

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