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Cheap flights from Detroit to Knoxville from $55

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Knoxville departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:58 pm - 9:59 amDTW-TYS
16h 01m1 stop
Multiple Airlines Logo
8:30 am - 8:20 amTYS-DTW
23h 50m1 stop
$182Multiple Airlines
Find Deal
Tue, Dec 9 - Thu, Dec 11
Multiple Airlines Logo
6:25 am - 10:07 pmDTW-TYS
15h 42m1 stop
Multiple Airlines Logo
9:29 am - 5:09 pmTYS-DTW
7h 40m1 stop
$188Multiple Airlines
Find Deal
Mon, Jan 5 - Thu, Jan 8
Multiple Airlines Logo
5:58 pm - 9:59 amDTW-TYS
16h 01m1 stop
Multiple Airlines Logo
1:05 pm - 8:20 amTYS-DTW
19h 15m1 stop
$197Multiple Airlines
Find Deal
Tue, Dec 9 - Fri, Dec 12
Multiple Airlines Logo
9:18 am - 9:49 pmDTW-TYS
12h 31m1 stop
Multiple Airlines Logo
6:30 am - 4:19 pmTYS-DTW
9h 49m1 stop
$201Multiple Airlines
Find Deal
Mon, Dec 8 - Sun, Dec 14
Multiple Airlines Logo
9:28 pm - 12:57 pmDTW-TYS
15h 29m1 stop
Multiple Airlines Logo
8:30 am - 5:53 pmTYS-DTW
9h 23m1 stop
$203Multiple Airlines
Find Deal
Tue, Dec 9 - Thu, Dec 11
Multiple Airlines Logo
11:19 am - 9:44 pmDTW-TYS
34h 25m2 stops
Multiple Airlines Logo
8:30 am - 5:53 pmTYS-DTW
9h 23m1 stop
$205Multiple Airlines
Find Deal
Sat, Dec 6 - Thu, Dec 11
Multiple Airlines Logo
9:28 pm - 11:55 amDTW-TYS
14h 27m1 stop
Multiple Airlines Logo
6:30 am - 4:19 pmTYS-DTW
9h 49m1 stop
$206Multiple Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14
Multiple Airlines Logo
6:15 am - 6:12 pmDTW-TYS
11h 57m1 stop
Multiple Airlines Logo
6:30 am - 4:28 pmTYS-DTW
9h 58m1 stop
$208Multiple Airlines
Find Deal
Wed, Dec 17 - Fri, Dec 19
Multiple Airlines Logo
11:19 am - 11:55 amDTW-TYS
24h 36m1 stop
Multiple Airlines Logo
6:30 am - 4:19 pmTYS-DTW
9h 49m1 stop
$209Multiple Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14
Multiple Airlines Logo
6:12 pm - 9:49 pmDTW-TYS
27h 37m1 stop
Multiple Airlines Logo
8:30 am - 5:53 pmTYS-DTW
9h 23m1 stop
$210Multiple Airlines
Find Deal
Sun, Dec 7 - Thu, Dec 11

Delta flights from Detroit to Knoxville

Our best Delta deals on Detroit to Knoxville flight tickets
Delta
Dec 4
DTW10:06 amDetroit Metropolitan Wayne County
1h 41m
TYS11:47 amKnoxville McGhee Tyson
Dec 8
TYS12:50 pmKnoxville McGhee Tyson
1h 46m
DTW2:36 pmDetroit Metropolitan Wayne County
$399
Find similar
Delta
Dec 4
DTW6:20 pmDetroit Metropolitan Wayne County
1h 40m
TYS8:00 pmKnoxville McGhee Tyson
Dec 8
TYS5:25 pmKnoxville McGhee Tyson
5h 05m
1 stop
DTW10:30 pmDetroit Metropolitan Wayne County
$409
Find similar
Delta
Dec 3
DTW6:20 pmDetroit Metropolitan Wayne County
1h 40m
TYS8:00 pmKnoxville McGhee Tyson
Dec 7
TYS7:39 amKnoxville McGhee Tyson
1h 50m
DTW9:29 amDetroit Metropolitan Wayne County
$459
Find similar

United Airlines flights from Detroit to Knoxville

Our best United Airlines deals on Detroit to Knoxville flight tickets
United Airlines
Nov 28
DTW5:45 amDetroit Metropolitan Wayne County
5h 03m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Dec 1
TYS7:20 pmKnoxville McGhee Tyson
4h 39m
1 stop
DTW11:59 pmDetroit Metropolitan Wayne County
$479
Find similar
United Airlines
Nov 21
DTW2:35 pmDetroit Metropolitan Wayne County
5h 45m
1 stop
TYS8:20 pmKnoxville McGhee Tyson
Nov 23
TYS6:45 amKnoxville McGhee Tyson
6h 26m
1 stop
DTW1:11 pmDetroit Metropolitan Wayne County
$559
Find similar
United Airlines
Nov 21
DTW7:45 pmDetroit Metropolitan Wayne County
4h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Nov 23
TYS2:25 pmKnoxville McGhee Tyson
9h 13m
2 stops
DTW11:38 pmDetroit Metropolitan Wayne County
$564
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Detroit to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 12/9

5:58 pm-9:59 am

1 stop16h 01m

Knoxville McGhee Tyson

Thu 12/11

8:30 am-8:20 am

1 stop23h 50m

$182

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Mon 1/5

6:25 am-10:07 pm

1 stop15h 42m

Knoxville McGhee Tyson

Thu 1/8

9:29 am-5:09 pm

1 stop7h 40m

$188

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 12/9

5:58 pm-9:59 am

1 stop16h 01m

Knoxville McGhee Tyson

Fri 12/12

1:05 pm-8:20 am

1 stop19h 15m

$197

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Mon 12/8

9:18 am-9:49 pm

1 stop12h 31m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-4:19 pm

1 stop9h 49m

$201

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 12/9

9:28 pm-12:57 pm

1 stop15h 29m

Knoxville McGhee Tyson

Thu 12/11

8:30 am-5:53 pm

1 stop9h 23m

$203

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sat 12/6

11:19 am-9:44 pm

2 stops34h 25m

Knoxville McGhee Tyson

Thu 12/11

8:30 am-5:53 pm

1 stop9h 23m

$205

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 12/11

9:28 pm-11:55 am

1 stop14h 27m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-4:19 pm

1 stop9h 49m

$206

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 12/17

6:15 am-6:12 pm

1 stop11h 57m

Knoxville McGhee Tyson

Fri 12/19

6:30 am-4:28 pm

1 stop9h 58m

$208

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 12/11

11:19 am-11:55 am

1 stop24h 36m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-4:19 pm

1 stop9h 49m

$209

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sun 12/7

6:12 pm-9:49 pm

1 stop27h 37m

Knoxville McGhee Tyson

Thu 12/11

8:30 am-5:53 pm

1 stop9h 23m

$210

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Detroit to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Detroit, with most prices found around $358. If you aren’t able to travel during the month of April, then book flights to Knoxville from Detroit during December instead. Flights to Knoxville in December, while not as cheap as those in April, still average around $359.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Detroit to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $399. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Knoxville for around $497.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Detroit to Knoxville when you can find flight prices for as low as $419. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $477.

What is the cheapest Detroit to Knoxville McGhee Tyson flight route?

Fly from Detroit Metropolitan Wayne County to Knoxville McGhee Tyson for the best Detroit - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $441 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Detroit for as low as $349 on momondo.

What cabin class options are available on Detroit to Knoxville McGhee Tyson flights?

There are 3 cabin classes available to choose from on Detroit to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to Knoxville flights?

You could potentially save up to 31% on your flight if you consider stops on a Detroit to Knoxville flight.

When to book flights from Detroit to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Knoxville (DTT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Knoxville

Best Price Found

$278

Fastest flight time

1h 37m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Detroit in the past 72 hours is $278. The best round-trip flight deal from Detroit to Knoxville found on momondo in the last 72 hours is $359.
The fastest flight from Detroit to Knoxville takes 1h 37m
Direct flights go from Detroit to Knoxville every day.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Detroit to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 442.8 mi away from Detroit. Flights usually cover this in 7h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Knoxville McGhee Tyson Airport?

    Prices for flights from Detroit to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Detroit to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit to Knoxville?

  • What is the most popular airline from Detroit to Knoxville?

Best airlines flying from Detroit to Knoxville

Compare and see reviews for airlines that fly from Detroit to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $216Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
DeltaPriceFrom $311Free CancellationRating
7.9
8,002 reviews
Search Delta flights

  • Delta Flights From Detroit to Knoxville

    Delta flies from Detroit to Knoxville around 13 times per week, with 8,002 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit to Knoxville in the last 72 hours was $311 (round-trip), much lower than the average airfare cost of $454 for Delta flights on this route.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Knoxville?

It is quick and easy to find Detroit to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Detroit to Knoxville with flexible booking policies on momondo?

All flight searches from Detroit to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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