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Cheap flights from Detroit to Knoxville from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Knoxville departing on 12/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:00 pm - 9:55 pmDTW-TYS
25h 55m1 stop
Multiple Airlines Logo
8:30 am - 6:00 pmTYS-DTW
9h 30m1 stop
$225Multiple Airlines
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Sun, Nov 2 - Sun, Nov 9
Multiple Airlines Logo
6:55 pm - 6:22 pmDTW-TYS
47h 27m2 stops
Multiple Airlines Logo
7:30 am - 2:03 pmTYS-DTW
6h 33m1 stop
$228Multiple Airlines
Find Deal
Tue, Nov 11 - Tue, Nov 18
Multiple Airlines Logo
9:30 am - 9:49 pmDTW-TYS
12h 19m1 stop
Multiple Airlines Logo
5:23 pm - 8:22 amTYS-DTW
14h 59m1 stop
$230Multiple Airlines
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Mon, Dec 8 - Thu, Dec 11
Delta Logo
6:20 pm - 8:00 pmDTW-TYS
1h 40mnonstop
Delta Logo
7:39 am - 9:29 amTYS-DTW
1h 50mnonstop
$299Delta
Find Deal
Fri, Dec 12 - Mon, Dec 15
Delta Logo
9:05 am - 2:48 pmDTW-TYS
5h 43m1 stop
Delta Logo
12:49 pm - 2:36 pmTYS-DTW
1h 47mnonstop
$309Delta
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Tue, Nov 11 - Tue, Nov 18
American Airlines Logo
8:17 am - 3:46 pmDTW-TYS
7h 29m1 stop
American Airlines Logo
8:06 am - 6:15 pmTYS-DTW
10h 09m1 stop
$317American Airlines
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Sat, Dec 13 - Tue, Dec 16
American Airlines Logo
11:10 am - 6:01 pmDTW-TYS
6h 51m2 stops
American Airlines Logo
1:13 pm - 11:21 pmTYS-DTW
10h 08m1 stop
$322American Airlines
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Sat, Nov 15 - Tue, Nov 18
Southwest Logo
3:35 pm - 10:10 pmDTW-TYS
6h 35m1 stop
Southwest Logo
7:25 pm - 11:05 pmTYS-DTW
3h 40m1 stop
$337Southwest
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Thu, Mar 19 - Thu, Mar 26
United Airlines Logo
2:19 pm - 9:02 pmDTW-TYS
6h 43m1 stop
United Airlines Logo
2:25 pm - 11:49 pmTYS-DTW
9h 24m2 stops
$338United Airlines
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Fri, Feb 6 - Tue, Feb 10
Southwest Logo
6:00 am - 6:45 pmDTW-TYS
12h 45m2 stops
Southwest Logo
7:25 pm - 11:05 pmTYS-DTW
3h 40m1 stop
$378Southwest
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Thu, Mar 19 - Thu, Mar 26

Delta flights from Detroit to Knoxville

Our best Delta deals on Detroit to Knoxville flight tickets
Delta
Dec 12
DTW6:20 pmDetroit Metropolitan Wayne County
1h 40m
TYS8:00 pmKnoxville McGhee Tyson
Dec 15
TYS7:39 amKnoxville McGhee Tyson
1h 50m
DTW9:29 amDetroit Metropolitan Wayne County
$299
Find similar
Delta
Nov 11
DTW9:05 amDetroit Metropolitan Wayne County
5h 43m
1 stop
TYS2:48 pmKnoxville McGhee Tyson
Nov 18
TYS12:49 pmKnoxville McGhee Tyson
1h 47m
DTW2:36 pmDetroit Metropolitan Wayne County
$309
Find similar
Delta
Nov 15
DTW6:20 pmDetroit Metropolitan Wayne County
1h 40m
TYS8:00 pmKnoxville McGhee Tyson
Nov 18
TYS7:39 amKnoxville McGhee Tyson
1h 51m
DTW9:30 amDetroit Metropolitan Wayne County
$319
Find similar

American Airlines flights from Detroit to Knoxville

Our best American Airlines deals on Detroit to Knoxville flight tickets
American Airlines
Dec 13
DTW8:17 amDetroit Metropolitan Wayne County
7h 29m
1 stop
TYS3:46 pmKnoxville McGhee Tyson
Dec 16
TYS8:06 amKnoxville McGhee Tyson
10h 09m
1 stop
DTW6:15 pmDetroit Metropolitan Wayne County
$317
Find similar
American Airlines
Nov 15
DTW11:10 amDetroit Metropolitan Wayne County
6h 51m
2 stops
TYS6:01 pmKnoxville McGhee Tyson
Nov 18
TYS1:13 pmKnoxville McGhee Tyson
10h 08m
1 stop
DTW11:21 pmDetroit Metropolitan Wayne County
$322
Find similar
American Airlines
Feb 19
DTW8:52 amDetroit Metropolitan Wayne County
8h 39m
1 stop
TYS5:31 pmKnoxville McGhee Tyson
Feb 22
TYS8:13 amKnoxville McGhee Tyson
5h 43m
1 stop
DTW1:56 pmDetroit Metropolitan Wayne County
$354
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momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 7, 2025.
Use the filters below to find and compare flights from Detroit to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sun 11/2

8:00 pm-9:55 pm

1 stop25h 55m

Knoxville McGhee Tyson

Sun 11/9

8:30 am-6:00 pm

1 stop9h 30m

$225

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 11/11

6:55 pm-6:22 pm

2 stops47h 27m

Knoxville McGhee Tyson

Tue 11/18

7:30 am-2:03 pm

1 stop6h 33m

$228

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Mon 12/8

9:30 am-9:49 pm

1 stop12h 19m

Knoxville McGhee Tyson

Thu 12/11

5:23 pm-8:22 am

1 stop14h 59m

$230

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 12/12

6:20 pm-8:00 pm

Nonstop1h 40m

Knoxville McGhee Tyson

Mon 12/15

7:39 am-9:29 am

Nonstop1h 50m

$299

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 11/11

9:05 am-2:48 pm

1 stop5h 43m

Knoxville McGhee Tyson

Tue 11/18

12:49 pm-2:36 pm

Nonstop1h 47m

$309

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sat 12/13

8:17 am-3:46 pm

1 stop7h 29m

Knoxville McGhee Tyson

Tue 12/16

8:06 am-6:15 pm

1 stop10h 09m

$317

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sat 11/15

11:10 am-6:01 pm

2 stops6h 51m

Knoxville McGhee Tyson

Tue 11/18

1:13 pm-11:21 pm

1 stop10h 08m

$322

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 3/19

3:35 pm-10:10 pm

1 stop6h 35m

Knoxville McGhee Tyson

Thu 3/26

7:25 pm-11:05 pm

1 stop3h 40m

$337

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 2/6

2:19 pm-9:02 pm

1 stop6h 43m

Knoxville McGhee Tyson

Tue 2/10

2:25 pm-11:49 pm

2 stops9h 24m

$338

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 3/19

6:00 am-6:45 pm

2 stops12h 45m

Knoxville McGhee Tyson

Thu 3/26

7:25 pm-11:05 pm

1 stop3h 40m

$378

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Detroit to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from Detroit, with most prices found around $349. If you aren’t able to travel during the month of December, then book flights to Knoxville from Detroit during April instead. Flights to Knoxville in April, while not as cheap as those in December, still average around $358.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Detroit to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $399. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Knoxville for around $497.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Detroit to Knoxville when you can find flight prices for as low as $422. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $473.

What is the cheapest Detroit to Knoxville McGhee Tyson flight route?

Fly from Detroit Metropolitan Wayne County to Knoxville McGhee Tyson for the best Detroit - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $438 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Detroit for as low as $350 on momondo.

What cabin class options are available on Detroit to Knoxville McGhee Tyson flights?

There are 3 cabin classes available to choose from on Detroit to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Detroit to Knoxville.

When to book flights from Detroit to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Knoxville (DTT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Knoxville

Best Price Found

$218

Fastest flight time

1h 34m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Detroit in the past 72 hours is $218. The best round-trip flight deal from Detroit to Knoxville found on momondo in the last 72 hours is $328.
The fastest flight from Detroit to Knoxville takes 1h 34m
Direct flights go from Detroit to Knoxville every day.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Detroit to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 442.8 mi away from Detroit. Flights usually cover this in 1h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Knoxville McGhee Tyson Airport?

    Prices for flights from Detroit to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Detroit to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit to Knoxville?

  • What is the most popular airline from Detroit to Knoxville?

Best airlines flying from Detroit to Knoxville

Compare and see reviews for airlines that fly from Detroit to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $216Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $309Free CancellationRating
7.9
7,967 reviews
Search Delta flights

  • Delta Flights From Detroit to Knoxville

    Delta flies from Detroit to Knoxville around 13 times per week, with 7,969 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit to Knoxville in the last 72 hours was $309 (round-trip), much lower than the average airfare cost of $454 for Delta flights on this route.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Knoxville?

It is quick and easy to find Detroit to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Detroit to Knoxville with flexible booking policies on momondo?

All flight searches from Detroit to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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