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Cheap flights from Detroit to Knoxville from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Knoxville departing on 2/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:50 pm - 10:36 am
DTW
-
TYS
15h 46m
1 stop
Multiple Airlines Logo
10:22 am - 11:12 am
TYS
-
DTW
48h 50m
2 stops
$254Multiple Airlines
Tue, Mar 31 - Sun, Apr 5
Multiple Airlines Logo
5:00 am - 12:05 pm
DTW
-
TYS
7h 05m
1 stop
Multiple Airlines Logo
4:30 pm - 11:55 pm
TYS
-
DTW
31h 25m
1 stop
$265Multiple Airlines
Fri, Feb 6 - Mon, Feb 9
Multiple Airlines Logo
2:06 pm - 11:40 am
DTW
-
TYS
21h 34m
2 stops
Multiple Airlines Logo
4:30 pm - 11:55 pm
TYS
-
DTW
31h 25m
1 stop
$268Multiple Airlines
Fri, Feb 6 - Mon, Feb 9
Multiple Airlines Logo
10:10 am - 10:07 pm
DTW
-
TYS
11h 57m
2 stops
Multiple Airlines Logo
9:36 pm - 9:15 am
TYS
-
DTW
11h 39m
1 stop
$269Multiple Airlines
Thu, Feb 26 - Mon, Mar 2
Multiple Airlines Logo
6:02 pm - 10:25 pm
DTW
-
TYS
28h 23m
2 stops
Multiple Airlines Logo
12:06 pm - 9:11 am
TYS
-
DTW
21h 05m
1 stop
$272Multiple Airlines
Sat, Feb 14 - Thu, Feb 19
Multiple Airlines Logo
9:01 am - 7:03 pm
DTW
-
TYS
10h 02m
1 stop
Multiple Airlines Logo
9:43 pm - 9:23 am
TYS
-
DTW
11h 40m
1 stop
$273Multiple Airlines
Wed, Mar 11 - Sun, Mar 15
Multiple Airlines Logo
5:09 am - 12:00 pm
DTW
-
TYS
6h 51m
1 stop
Multiple Airlines Logo
7:20 am - 1:30 pm
TYS
-
DTW
30h 10m
2 stops
$276Multiple Airlines
Fri, Mar 6 - Sun, Mar 8
Southwest Logo
6:15 am - 11:40 am
DTW
-
TYS
5h 25m
1 stop
Southwest Logo
8:15 am - 6:20 pm
TYS
-
DTW
10h 05m
2 stops
$278Southwest
Sat, May 9 - Tue, May 12
Multiple Airlines Logo
5:07 pm - 10:44 am
DTW
-
TYS
17h 37m
2 stops
Multiple Airlines Logo
9:43 pm - 9:23 am
TYS
-
DTW
11h 40m
1 stop
$283Multiple Airlines
Wed, Mar 11 - Sun, Mar 15
Southwest Logo
7:20 am - 3:20 pm
DTW
-
TYS
8h 00m
2 stops
Southwest Logo
8:15 am - 6:20 pm
TYS
-
DTW
10h 05m
2 stops
$284Southwest
Sat, May 9 - Tue, May 12

United Airlines flights from Detroit to Knoxville

Our best United Airlines deals on Detroit to Knoxville flight tickets
United Airlines
Apr 16
DTW6:00 amDetroit Metropolitan Wayne County
4h 08m
1 stop
TYS10:08 amKnoxville McGhee Tyson
Apr 19
TYS7:00 amKnoxville McGhee Tyson
6h 20m
1 stop
DTW1:20 pmDetroit Metropolitan Wayne County
$333
United Airlines
Feb 6
DTW2:19 pmDetroit Metropolitan Wayne County
6h 33m
1 stop
TYS8:52 pmKnoxville McGhee Tyson
Feb 10
TYS1:59 pmKnoxville McGhee Tyson
6h 27m
1 stop
DTW8:26 pmDetroit Metropolitan Wayne County
$479
United Airlines
Feb 5
DTW6:00 amDetroit Metropolitan Wayne County
10h 53m
2 stops
TYS4:53 pmKnoxville McGhee Tyson
Feb 8
TYS2:25 pmKnoxville McGhee Tyson
4h 34m
1 stop
DTW6:59 pmDetroit Metropolitan Wayne County
$484

Delta flights from Detroit to Knoxville

Our best Delta deals on Detroit to Knoxville flight tickets
Delta
Mar 6
DTW7:10 pmDetroit Metropolitan Wayne County
1h 45m
TYS8:55 pmKnoxville McGhee Tyson
Mar 13
TYS7:40 amKnoxville McGhee Tyson
1h 40m
DTW9:20 amDetroit Metropolitan Wayne County
$299
Delta
Mar 20
DTW3:10 pmDetroit Metropolitan Wayne County
1h 33m
TYS4:43 pmKnoxville McGhee Tyson
Mar 23
TYS5:40 amKnoxville McGhee Tyson
3h 45m
1 stop
DTW9:25 amDetroit Metropolitan Wayne County
$309
Delta
Feb 26
DTW10:20 amDetroit Metropolitan Wayne County
1h 51m
TYS12:11 pmKnoxville McGhee Tyson
Mar 1
TYS7:38 amKnoxville McGhee Tyson
1h 52m
DTW9:30 amDetroit Metropolitan Wayne County
$339

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from Detroit to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 3/31

6:50 pm-10:36 am

1 stop15h 46m

Knoxville McGhee Tyson

Sun 4/5

10:22 am-11:12 am

2 stops48h 50m

$254

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 2/6

5:00 am-12:05 pm

1 stop7h 05m

Knoxville McGhee Tyson

Mon 2/9

4:30 pm-11:55 pm

1 stop31h 25m

$265

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 2/6

2:06 pm-11:40 am

2 stops21h 34m

Knoxville McGhee Tyson

Mon 2/9

4:30 pm-11:55 pm

1 stop31h 25m

$268

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 2/26

10:10 am-10:07 pm

2 stops11h 57m

Knoxville McGhee Tyson

Mon 3/2

9:36 pm-9:15 am

1 stop11h 39m

$269

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sat 2/14

6:02 pm-10:25 pm

2 stops28h 23m

Knoxville McGhee Tyson

Thu 2/19

12:06 pm-9:11 am

1 stop21h 05m

$272

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 3/11

9:01 am-7:03 pm

1 stop10h 02m

Knoxville McGhee Tyson

Sun 3/15

9:43 pm-9:23 am

1 stop11h 40m

$273

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 3/6

5:09 am-12:00 pm

1 stop6h 51m

Knoxville McGhee Tyson

Sun 3/8

7:20 am-1:30 pm

2 stops30h 10m

$276

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sat 5/9

6:15 am-11:40 am

1 stop5h 25m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-6:20 pm

2 stops10h 05m

$278

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 3/11

5:07 pm-10:44 am

2 stops17h 37m

Knoxville McGhee Tyson

Sun 3/15

9:43 pm-9:23 am

1 stop11h 40m

$283

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Sat 5/9

7:20 am-3:20 pm

2 stops8h 00m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-6:20 pm

2 stops10h 05m

$284

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Detroit to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Detroit, with most prices found around $339. If you aren’t able to travel during the month of April, then book flights to Knoxville from Detroit during May instead. Flights to Knoxville in May, while not as cheap as those in April, still average around $409.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Detroit to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $399. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Knoxville for around $497.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Detroit to Knoxville when you can find flight prices for as low as $416. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $492.

What is the cheapest Detroit to Knoxville McGhee Tyson flight route?

Fly from Detroit Metropolitan Wayne County to Knoxville McGhee Tyson for the best Detroit - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $458 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Detroit for as low as $319 on momondo.

What cabin class options are available on Detroit to Knoxville McGhee Tyson flights?

There are 2 cabin classes available to choose from on Detroit to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to Knoxville flights?

You could potentially save up to 72% on your flight if you consider stops on a Detroit to Knoxville flight.

When to book flights from Detroit to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Knoxville (DTT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Knoxville

Best Price Found

$498

Fastest flight time

1h 33m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Detroit in the past 72 hours is $498. The best round-trip flight deal from Detroit to Knoxville found on momondo in the last 72 hours is $339.
The fastest flight from Detroit to Knoxville takes 1h 33m
Direct flights go from Detroit to Knoxville on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is Delta.
There is 1 airport in Knoxville. From Detroit there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Detroit to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 442.8 mi away from Detroit. Flights usually cover this in 1h 33m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Knoxville McGhee Tyson Airport?

    Prices for flights from Detroit to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Detroit to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit to Knoxville?

  • What is the most popular airline from Detroit to Knoxville?

Best airlines flying from Detroit to Knoxville

Compare and see reviews for airlines that fly from Detroit to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $216Free CancellationRating
7.2
11,192 reviews
Search American Airlines flights
DeltaPriceFrom $299Free CancellationRating
7.9
8,110 reviews
Search Delta flights

  • Delta Flights From Detroit to Knoxville

    Delta flies from Detroit to Knoxville around 13 times per week, with 8,110 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit to Knoxville in the last 72 hours was $299 (round-trip), much lower than the average airfare cost of $438 for Delta flights on this route.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Murphy
Alcoa
Crossville
Maryville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Knoxville?

It is quick and easy to find Detroit to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Detroit to Knoxville with flexible booking policies on momondo?

All flight searches from Detroit to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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