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Cheap flights from Detroit to Knoxville from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Knoxville departing on 9/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:00 am - 12:05 pm
DTW
-
TYS
6h 05m
1 stop
Southwest Logo
5:30 pm - 9:30 pm
TYS
-
DTW
4h 00m
1 stop
$212Southwest
Tue, Sep 8 - Wed, Sep 30
Southwest Logo
6:00 am - 12:05 pm
DTW
-
TYS
6h 05m
1 stop
Southwest Logo
12:45 pm - 8:30 pm
TYS
-
DTW
7h 45m
2 stops
$217Southwest
Tue, Sep 8 - Wed, Sep 30
Southwest Logo
6:00 am - 12:15 pm
DTW
-
TYS
6h 15m
1 stop
Southwest Logo
7:55 am - 3:15 pm
TYS
-
DTW
7h 20m
1 stop
$228Southwest
Wed, Nov 4 - Wed, Nov 11
Southwest Logo
2:45 pm - 7:50 pm
DTW
-
TYS
5h 05m
1 stop
Southwest Logo
7:50 am - 12:30 pm
TYS
-
DTW
4h 40m
1 stop
$232Southwest
Tue, Aug 25 - Sat, Aug 29
Southwest Logo
6:50 am - 2:00 pm
DTW
-
TYS
7h 10m
2 stops
Southwest Logo
7:55 am - 3:15 pm
TYS
-
DTW
7h 20m
1 stop
$233Southwest
Wed, Nov 4 - Wed, Nov 11
Southwest Logo
12:55 pm - 6:55 pm
DTW
-
TYS
6h 00m
2 stops
Southwest Logo
7:50 am - 12:30 pm
TYS
-
DTW
4h 40m
1 stop
$237Southwest
Tue, Aug 25 - Sat, Aug 29
Southwest Logo
6:25 am - 2:20 pm
DTW
-
TYS
7h 55m
2 stops
Southwest Logo
7:50 am - 6:55 pm
TYS
-
DTW
11h 05m
2 stops
$248Southwest
Tue, Aug 25 - Sat, Aug 29
Multiple Airlines Logo
9:12 am - 8:32 am
DTW
-
TYS
23h 20m
1 stop
Multiple Airlines Logo
12:53 pm - 11:32 am
TYS
-
DTW
22h 39m
1 stop
$252Multiple Airlines
Fri, Jul 24 - Mon, Jul 27
Multiple Airlines Logo
6:10 am - 10:00 pm
DTW
-
TYS
15h 50m
2 stops
Multiple Airlines Logo
1:05 pm - 12:55 pm
TYS
-
DTW
23h 50m
1 stop
$255Multiple Airlines
Fri, Jul 10 - Wed, Jul 15
Southwest Logo
6:00 am - 1:05 pm
DTW
-
TYS
7h 05m
2 stops
Southwest Logo
5:45 pm - 10:05 pm
TYS
-
DTW
4h 20m
1 stop
$257Southwest
Tue, Aug 4 - Fri, Aug 7

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Southwest flights from Detroit to Knoxville

Our best Southwest deals on Detroit to Knoxville flight tickets
Southwest
Sep 8
DTW6:00 amDetroit Metropolitan Wayne County
6h 05m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
Sep 30
TYS5:30 pmKnoxville McGhee Tyson
4h 00m
1 stop
DTW9:30 pmDetroit Metropolitan Wayne County
$212
Southwest
Sep 8
DTW6:00 amDetroit Metropolitan Wayne County
6h 05m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
Sep 30
TYS12:45 pmKnoxville McGhee Tyson
7h 45m
2 stops
DTW8:30 pmDetroit Metropolitan Wayne County
$217
Southwest
Aug 25
DTW2:45 pmDetroit Metropolitan Wayne County
5h 05m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Aug 29
TYS7:50 amKnoxville McGhee Tyson
4h 40m
1 stop
DTW12:30 pmDetroit Metropolitan Wayne County
$232

Frontier flights from Detroit to Knoxville

Our best Frontier deals on Detroit to Knoxville flight tickets
Frontier
Jul 13
DTW7:40 amDetroit Metropolitan Wayne County
11h 44m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
Jul 15
TYS8:19 pmKnoxville McGhee Tyson
27h 40m
1 stop
DTW11:59 pmDetroit Metropolitan Wayne County
$261
Frontier
Jul 13
DTW7:40 amDetroit Metropolitan Wayne County
11h 44m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
Jul 15
TYS8:19 pmKnoxville McGhee Tyson
27h 40m
1 stop
DTW11:59 pmDetroit Metropolitan Wayne County
$262
Frontier
Aug 10
DTW7:40 amDetroit Metropolitan Wayne County
11h 44m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
Aug 17
TYS8:19 pmKnoxville McGhee Tyson
16h 18m
1 stop
DTW12:37 pmDetroit Metropolitan Wayne County
$270

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Detroit to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 9/8

6:00 am-12:05 pm

1 stop6h 05m

Knoxville McGhee Tyson

Wed 9/30

5:30 pm-9:30 pm

1 stop4h 00m

$212

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 9/8

6:00 am-12:05 pm

1 stop6h 05m

Knoxville McGhee Tyson

Wed 9/30

12:45 pm-8:30 pm

2 stops7h 45m

$217

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 11/4

6:00 am-12:15 pm

1 stop6h 15m

Knoxville McGhee Tyson

Wed 11/11

7:55 am-3:15 pm

1 stop7h 20m

$228
Quickest round-trip

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 8/25

2:45 pm-7:50 pm

1 stop5h 05m

Knoxville McGhee Tyson

Sat 8/29

7:50 am-12:30 pm

1 stop4h 40m

$232

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 11/4

6:50 am-2:00 pm

2 stops7h 10m

Knoxville McGhee Tyson

Wed 11/11

7:55 am-3:15 pm

1 stop7h 20m

$233

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 8/25

12:55 pm-6:55 pm

2 stops6h 00m

Knoxville McGhee Tyson

Sat 8/29

7:50 am-12:30 pm

1 stop4h 40m

$237

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 8/25

6:25 am-2:20 pm

2 stops7h 55m

Knoxville McGhee Tyson

Sat 8/29

7:50 am-6:55 pm

2 stops11h 05m

$248

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 7/24

9:12 am-8:32 am

1 stop23h 20m

Knoxville McGhee Tyson

Mon 7/27

12:53 pm-11:32 am

1 stop22h 39m

$252

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 7/10

6:10 am-10:00 pm

2 stops15h 50m

Knoxville McGhee Tyson

Wed 7/15

1:05 pm-12:55 pm

1 stop23h 50m

$255

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 8/4

6:00 am-1:05 pm

2 stops7h 05m

Knoxville McGhee Tyson

Fri 8/7

5:45 pm-10:05 pm

1 stop4h 20m

$257

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Detroit to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Detroit, with most prices found around $218. If you aren’t able to travel during the month of October, then book flights to Knoxville from Detroit during December instead. Flights to Knoxville in December, while not as cheap as those in October, still average around $226.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Detroit to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $339. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Knoxville for around $478.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Detroit to Knoxville when you can find flight prices for as low as $401. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $499.

What is the cheapest Detroit to Knoxville McGhee Tyson flight route?

Fly from Detroit Metropolitan Wayne County to Knoxville McGhee Tyson for the best Detroit - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight from Detroit to Knoxville?

You are more likely to see cheaper flights to Knoxville from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $456 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Detroit for as low as $313 on momondo.

What cabin class options are available on Detroit to Knoxville flights?

There is only 1 cabin class available to choose from on Detroit to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to Knoxville flights?

You could potentially save up to 44% on your flight if you consider stops on a Detroit to Knoxville flight.

When to book flights from Detroit to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Knoxville (DTT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Knoxville

Best Price Found

$248

Fastest flight time

1h 38m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Detroit in the past 72 hours is $248. The best round-trip flight deal from Detroit to Knoxville found on momondo in the last 72 hours is $399.
The fastest flight from Detroit to Knoxville takes 1h 38m
Direct flights go from Detroit to Knoxville every day.
There is 1 airport in Knoxville. From Detroit there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Detroit to Knoxville

  • How far is Detroit to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 442.8 mi away from Detroit. Flights usually cover this in 1h 38m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Knoxville McGhee Tyson Airport?

    Prices for flights from Detroit to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Detroit to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit to Knoxville?

  • What is the most popular airline from Detroit to Knoxville?

Best airlines flying from Detroit to Knoxville

Compare and see reviews for airlines that fly from Detroit to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $299Free CancellationRating
7.9
8,395 reviews
Search Delta flights

  • Delta Flights From Detroit to Knoxville

    Delta flies from Detroit to Knoxville around 26 times per week, with 8,396 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit to Knoxville in the last 72 hours was $299 (round-trip), much lower than the average airfare cost of $421 for Delta flights on this route.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Knoxville?

It is quick and easy to find Detroit to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Detroit to Knoxville with flexible booking policies on momondo?

All flight searches from Detroit to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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