Cheap flights from Detroit to Knoxville from $75

The month of April is, on average, the cheapest month to fly to Knoxville from Detroit, with most prices found around $385. If you aren’t able to travel during the month of April, then book flights to Knoxville from Detroit during July instead. Flights to Knoxville in July, while not as cheap as those in April, still average around $409.

The cheapest day to depart from Detroit to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $379. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Knoxville for around $468.

In the morning is the cheapest time of day to fly from Detroit to Knoxville when you can find flight prices for as low as $412. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $479.

Fly from Detroit Metropolitan Wayne County to Knoxville McGhee Tyson for the best Detroit - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $472 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Detroit for as low as $346 on momondo.

There are 4 cabin classes available to choose from on Detroit to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 35% on your flight if you consider stops on a Detroit to Knoxville flight.

Southwest and Delta are the most popular carriers operating from Detroit to Knoxville McGhee Tyson

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Knoxville from Detroit according to our data. Delta is the first choice among our users, with 74% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

As of August 2026, 5 flights take off from Detroit and land in Knoxville each day. The most common flight departure time for this route is 7:00PM, with 51% of daily flights taking off in the afternoon.

As of August 2026, there are 40 flights per week flying from Detroit to Knoxville. The most common day of the week flights depart is Fri, with 38% of flights taking off on this day.