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Cheap flights from Des Moines to Lexington from $316

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Lexington departing on 12/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Lexington

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:00 am - 2:11 pmDSM-LEX
27h 11m1 stop
Allegiant Air Logo
10:22 pm - 2:10 pmLEX-DSM
16h 48m1 stop
$316Allegiant Air
Find Deal
Tue, Dec 16 - Tue, Dec 23
United Airlines Logo
6:45 pm - 11:41 pmDSM-LEX
3h 56m1 stop
United Airlines Logo
10:35 am - 2:27 pmLEX-DSM
4h 52m1 stop
$319United Airlines
Find Deal
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
3:25 pm - 9:58 pmDSM-LEX
5h 33m1 stop
American Airlines Logo
1:17 pm - 9:52 pmLEX-DSM
9h 35m2 stops
$393American Airlines
Find Deal
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
11:26 am - 11:58 pmDSM-LEX
11h 32m2 stops
American Airlines Logo
7:11 pm - 9:52 pmLEX-DSM
3h 41m1 stop
$417American Airlines
Find Deal
Sat, Mar 7 - Wed, Mar 11
Allegiant Air Logo
10:00 am - 2:11 pmDSM-LEX
27h 11m1 stop
Allegiant Air Logo
3:22 pm - 7:41 amLEX-DSM
17h 19m2 stops
$463Allegiant Air
Find Deal
Tue, Dec 16 - Tue, Dec 23
American Airlines Logo
11:26 am - 11:58 pmDSM-LEX
11h 32m2 stops
American Airlines Logo
1:17 pm - 9:52 pmLEX-DSM
9h 35m2 stops
$466American Airlines
Find Deal
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
11:26 am - 11:58 pmDSM-LEX
11h 32m2 stops
American Airlines Logo
1:17 pm - 9:52 pmLEX-DSM
9h 35m2 stops
$515American Airlines
Find Deal
Sat, Mar 7 - Wed, Mar 11
Multiple Airlines Logo
10:50 am - 6:49 pmDSM-LEX
6h 59m1 stop
Multiple Airlines Logo
11:16 am - 8:44 amLEX-DSM
22h 28m2 stops
$585Multiple Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 20
United Airlines Logo
8:02 am - 1:17 pmDSM-LEX
4h 15m1 stop
United Airlines Logo
10:40 am - 2:19 pmLEX-DSM
4h 39m1 stop
$587United Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 20
Multiple Airlines Logo
10:50 am - 6:49 pmDSM-LEX
6h 59m1 stop
Multiple Airlines Logo
11:16 am - 12:55 pmLEX-DSM
26h 39m3 stops
$611Multiple Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 20

Allegiant Air flights from Des Moines to Lexington

Our best Allegiant Air deals on Des Moines to Lexington flight tickets
Allegiant Air
Dec 16
DSM10:00 amDes Moines
27h 11m
1 stop
LEX2:11 pmLexington Blue Grass
Dec 23
LEX10:22 pmLexington Blue Grass
16h 48m
1 stop
DSM2:10 pmDes Moines
$316
Find similar
Allegiant Air
Dec 16
DSM10:00 amDes Moines
27h 11m
1 stop
LEX2:11 pmLexington Blue Grass
Dec 23
LEX3:22 pmLexington Blue Grass
17h 19m
2 stops
DSM7:41 amDes Moines
$463
Find similar

United Airlines flights from Des Moines to Lexington

Our best United Airlines deals on Des Moines to Lexington flight tickets
United Airlines
Mar 7
DSM6:45 pmDes Moines
3h 56m
1 stop
LEX11:41 pmLexington Blue Grass
Mar 11
LEX10:35 amLexington Blue Grass
4h 52m
1 stop
DSM2:27 pmDes Moines
$319
Find similar
United Airlines
Nov 16
DSM8:02 amDes Moines
4h 15m
1 stop
LEX1:17 pmLexington Blue Grass
Nov 20
LEX10:40 amLexington Blue Grass
4h 39m
1 stop
DSM2:19 pmDes Moines
$587
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 12/16

10:00 am-2:11 pm

1 stop27h 11m

Lexington Blue Grass

Tue 12/23

10:22 pm-2:10 pm

1 stop16h 48m

$316

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 3/7

6:45 pm-11:41 pm

1 stop3h 56m

Lexington Blue Grass

Wed 3/11

10:35 am-2:27 pm

1 stop4h 52m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 3/7

3:25 pm-9:58 pm

1 stop5h 33m

Lexington Blue Grass

Wed 3/11

1:17 pm-9:52 pm

2 stops9h 35m

$393

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 3/7

11:26 am-11:58 pm

2 stops11h 32m

Lexington Blue Grass

Wed 3/11

7:11 pm-9:52 pm

1 stop3h 41m

$417

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 12/16

10:00 am-2:11 pm

1 stop27h 11m

Lexington Blue Grass

Tue 12/23

3:22 pm-7:41 am

2 stops17h 19m

$463

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 3/7

11:26 am-11:58 pm

2 stops11h 32m

Lexington Blue Grass

Wed 3/11

1:17 pm-9:52 pm

2 stops9h 35m

$466

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 3/7

11:26 am-11:58 pm

2 stops11h 32m

Lexington Blue Grass

Wed 3/11

1:17 pm-9:52 pm

2 stops9h 35m

$515

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sun 11/16

10:50 am-6:49 pm

1 stop6h 59m

Lexington Blue Grass

Thu 11/20

11:16 am-8:44 am

2 stops22h 28m

$585

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sun 11/16

8:02 am-1:17 pm

1 stop4h 15m

Lexington Blue Grass

Thu 11/20

10:40 am-2:19 pm

1 stop4h 39m

$587

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sun 11/16

10:50 am-6:49 pm

1 stop6h 59m

Lexington Blue Grass

Thu 11/20

11:16 am-12:55 pm

3 stops26h 39m

$611

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Lexington from

How to get the cheapest flight ticket from Des Moines to Lexington

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Lexington?

What is the cheapest day to depart on your flight to Lexington?

On average, the least expensive day to fly to Lexington from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $306. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $378.

What is the cheapest time of day to depart on your flight to Lexington?

The cheapest time of day to fly to Lexington is at noon when flights can be purchased for as low as $279. Try not to purchase tickets in the afternoon because they tend to be around $350. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Des Moines to Lexington

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Lexington according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Lexington (DSM to LEX) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Lexington

Direct flights

None
There are no direct flights from Des Moines to Lexington. There are no popular flight routes from Des Moines to Lexington.
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  • How far is Des Moines to Lexington Blue Grass by plane?

    Des Moines and Lexington Blue Grass are 542.1 mi apart from one another. A reasonable flight in good conditions will take 3h 56m.

  • When did momondo last update prices for flights from Des Moines Airport to Lexington Blue Grass Airport?

    Prices for flights from Des Moines Airport to Lexington Blue Grass Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Lexington Blue Grass Airport?

  • How old do you have to be to fly from Des Moines Airport to Lexington Blue Grass Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Lexington Blue Grass Airport.

  • What documentation or ID do you need to fly to Lexington Blue Grass Airport?

    The necessary travel and health documents for your Lexington Blue Grass Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Lexington?

Best airlines flying from Des Moines to Lexington

Compare and see reviews for airlines that fly from Des Moines to Lexington with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $225Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,034 reviews
Search American Airlines flights

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Richmond
Somerset
Georgetown
Danville
Frankfort
Winchester
Berea
Carlisle
Versailles

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Lexington?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Lexington from Des Moines.

Can I find flights from Des Moines to Lexington with flexible booking policies on momondo?

Flights from Des Moines to Lexington with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Lexington?

momondo helps you find the best flight between Des Moines and Lexington by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Lexington right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Lexington, momondo offers a useful price alert feature which will track prices for flights to Lexington from Des Moines and alert you when they change.

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