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Cheap flights from Des Moines to Lexington from $185

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Lexington departing on 6/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to Lexington

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:20 am - 1:13 pm
DSM
-
LEX
5h 53m
1 stop
United Airlines Logo
7:00 am - 10:44 am
LEX
-
DSM
4h 44m
1 stop
$329United Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
11:09 am - 3:57 pm
DSM
-
LEX
3h 48m
1 stop
American Airlines Logo
7:11 am - 4:31 pm
LEX
-
DSM
10h 20m
2 stops
$334American Airlines
Sat, Apr 18 - Sat, Apr 25
United Airlines Logo
7:16 pm - 11:59 pm
DSM
-
LEX
3h 43m
1 stop
United Airlines Logo
6:01 pm - 9:32 pm
LEX
-
DSM
4h 31m
1 stop
$339United Airlines
Thu, Apr 2 - Mon, Apr 6
American Airlines Logo
5:00 am - 11:12 am
DSM
-
LEX
5h 12m
1 stop
American Airlines Logo
6:12 pm - 11:45 pm
LEX
-
DSM
6h 33m
1 stop
$359American Airlines
Fri, Sep 4 - Tue, Sep 8
American Airlines Logo
5:00 am - 11:12 am
DSM
-
LEX
5h 12m
1 stop
American Airlines Logo
7:53 am - 3:08 pm
LEX
-
DSM
8h 15m
2 stops
$365American Airlines
Fri, Sep 4 - Tue, Sep 8
United Airlines Logo
6:20 am - 1:13 pm
DSM
-
LEX
5h 53m
1 stop
United Airlines Logo
7:00 am - 10:44 am
LEX
-
DSM
4h 44m
1 stop
$378United Airlines
Wed, Apr 8 - Sun, Apr 12
Delta Logo
6:30 pm - 11:55 pm
DSM
-
LEX
4h 25m
1 stop
Delta Logo
7:10 am - 1:22 pm
LEX
-
DSM
7h 12m
1 stop
$394Delta
Sat, Jun 13 - Wed, Jun 17
United Airlines Logo
7:16 pm - 11:59 pm
DSM
-
LEX
3h 43m
1 stop
United Airlines Logo
7:50 pm - 12:39 am
LEX
-
DSM
5h 49m
1 stop
$399United Airlines
Wed, Apr 29 - Sun, May 3
American Airlines Logo
2:16 pm - 11:52 pm
DSM
-
LEX
8h 36m
2 stops
American Airlines Logo
1:30 pm - 6:22 pm
LEX
-
DSM
5h 52m
1 stop
$407American Airlines
Wed, May 20 - Sun, May 24
United Airlines Logo
5:00 am - 1:10 pm
DSM
-
LEX
7h 10m
1 stop
United Airlines Logo
9:00 am - 12:19 pm
LEX
-
DSM
4h 19m
1 stop
$409United Airlines
Sat, Aug 29 - Wed, Sep 2

United Airlines flights from Des Moines to Lexington

Our best United Airlines deals on Des Moines to Lexington flight tickets
United Airlines
Apr 18
DSM6:20 amDes Moines
5h 53m
1 stop
LEX1:13 pmLexington Blue Grass
Apr 25
LEX7:00 amLexington Blue Grass
4h 44m
1 stop
DSM10:44 amDes Moines
$329
United Airlines
Apr 2
DSM7:16 pmDes Moines
3h 43m
1 stop
LEX11:59 pmLexington Blue Grass
Apr 6
LEX6:01 pmLexington Blue Grass
4h 31m
1 stop
DSM9:32 pmDes Moines
$339
United Airlines
Apr 8
DSM6:20 amDes Moines
5h 53m
1 stop
LEX1:13 pmLexington Blue Grass
Apr 12
LEX7:00 amLexington Blue Grass
4h 44m
1 stop
DSM10:44 amDes Moines
$378

American Airlines flights from Des Moines to Lexington

Our best American Airlines deals on Des Moines to Lexington flight tickets
American Airlines
Apr 18
DSM11:09 amDes Moines
3h 48m
1 stop
LEX3:57 pmLexington Blue Grass
Apr 25
LEX7:11 amLexington Blue Grass
10h 20m
2 stops
DSM4:31 pmDes Moines
$334
American Airlines
Sep 4
DSM5:00 amDes Moines
5h 12m
1 stop
LEX11:12 amLexington Blue Grass
Sep 8
LEX6:12 pmLexington Blue Grass
6h 33m
1 stop
DSM11:45 pmDes Moines
$359
American Airlines
Sep 4
DSM5:00 amDes Moines
5h 12m
1 stop
LEX11:12 amLexington Blue Grass
Sep 8
LEX7:53 amLexington Blue Grass
8h 15m
2 stops
DSM3:08 pmDes Moines
$365

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 4/18

6:20 am-1:13 pm

1 stop5h 53m

Lexington Blue Grass

Sat 4/25

7:00 am-10:44 am

1 stop4h 44m

$329

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 4/18

11:09 am-3:57 pm

1 stop3h 48m

Lexington Blue Grass

Sat 4/25

7:11 am-4:31 pm

2 stops10h 20m

$334
Quickest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 4/2

7:16 pm-11:59 pm

1 stop3h 43m

Lexington Blue Grass

Mon 4/6

6:01 pm-9:32 pm

1 stop4h 31m

$339

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 9/4

5:00 am-11:12 am

1 stop5h 12m

Lexington Blue Grass

Tue 9/8

6:12 pm-11:45 pm

1 stop6h 33m

$359

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 9/4

5:00 am-11:12 am

1 stop5h 12m

Lexington Blue Grass

Tue 9/8

7:53 am-3:08 pm

2 stops8h 15m

$365

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 4/8

6:20 am-1:13 pm

1 stop5h 53m

Lexington Blue Grass

Sun 4/12

7:00 am-10:44 am

1 stop4h 44m

$378

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 6/13

6:30 pm-11:55 pm

1 stop4h 25m

Lexington Blue Grass

Wed 6/17

7:10 am-1:22 pm

1 stop7h 12m

$394

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 4/29

7:16 pm-11:59 pm

1 stop3h 43m

Lexington Blue Grass

Sun 5/3

7:50 pm-12:39 am

1 stop5h 49m

$399

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 5/20

2:16 pm-11:52 pm

2 stops8h 36m

Lexington Blue Grass

Sun 5/24

1:30 pm-6:22 pm

1 stop5h 52m

$407

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 8/29

5:00 am-1:10 pm

1 stop7h 10m

Lexington Blue Grass

Wed 9/2

9:00 am-12:19 pm

1 stop4h 19m

$409

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Lexington from

How to get the cheapest flight ticket from Des Moines to Lexington

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Lexington Blue Grass?

Allegiant Air and Delta are the most popular carriers operating from Des Moines to Lexington Blue Grass

What airlines fly to Lexington?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Lexington from Des Moines according to our data. United Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Lexington. Keep in mind that there are 3 different airlines that fly to Lexington on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Lexington

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Lexington according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Lexington (DSM to LEX) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Lexington

Fastest flight time

3h 43m

Direct flights

None
The fastest flight from Des Moines to Lexington takes 3h 43m
There are no direct flights from Des Moines to Lexington. There are no popular flight routes from Des Moines to Lexington.
Search flight deals

  • How far is Des Moines to Lexington Blue Grass by plane?

    Des Moines and Lexington Blue Grass are 542.1 mi apart from one another. A reasonable flight in good conditions will take 3h 43m.

  • When did momondo last update prices for flights from Des Moines Airport to Lexington Blue Grass Airport?

    Prices for flights from Des Moines Airport to Lexington Blue Grass Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Lexington Blue Grass Airport?

  • How old do you have to be to fly from Des Moines Airport to Lexington Blue Grass Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Lexington Blue Grass Airport.

  • What documentation or ID do you need to fly to Lexington Blue Grass Airport?

    The necessary travel and health documents for your Lexington Blue Grass Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Lexington?

Best airlines flying from Des Moines to Lexington

Compare and see reviews for airlines that fly from Des Moines to Lexington with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
United AirlinesPriceFrom $225Free CancellationRating
7.4
9,455 reviews
Search United Airlines flights

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Richmond
Somerset
Georgetown
Danville
Frankfort
Winchester
Berea
Versailles
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Lexington?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Lexington from Des Moines.

Can I find flights from Des Moines to Lexington with flexible booking policies on momondo?

Flights from Des Moines to Lexington with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Lexington?

momondo helps you find the best flight between Des Moines and Lexington by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Lexington right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Lexington, momondo offers a useful price alert feature which will track prices for flights to Lexington from Des Moines and alert you when they change.

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