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Cheap flights from Des Moines to Lexington from $269

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Lexington departing on 7/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Lexington

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:04 am - 12:34 pm
DSM
-
LEX
4h 30m
1 stop
American Airlines Logo
8:05 am - 12:24 pm
LEX
-
DSM
5h 19m
1 stop
$308American Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
5:00 am - 10:50 am
DSM
-
LEX
4h 50m
1 stop
American Airlines Logo
8:10 pm - 12:09 am
LEX
-
DSM
4h 59m
1 stop
$309American Airlines
Fri, Jul 17 - Fri, Jul 24
American Airlines Logo
7:00 am - 6:43 pm
DSM
-
LEX
10h 43m
2 stops
American Airlines Logo
6:34 am - 10:00 am
LEX
-
DSM
4h 26m
1 stop
$314American Airlines
Sat, Aug 29 - Wed, Sep 2
Delta Logo
4:52 pm - 12:04 am
DSM
-
LEX
6h 12m
1 stop
Delta Logo
7:05 am - 10:45 am
LEX
-
DSM
4h 40m
1 stop
$324Delta
Sat, Jul 4 - Fri, Jul 10
American Airlines Logo
7:00 am - 6:43 pm
DSM
-
LEX
10h 43m
2 stops
American Airlines Logo
5:00 pm - 12:20 am
LEX
-
DSM
8h 20m
2 stops
$353American Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
5:00 am - 10:50 am
DSM
-
LEX
4h 50m
1 stop
American Airlines Logo
5:35 am - 8:23 am
LEX
-
DSM
3h 48m
1 stop
$358American Airlines
Fri, Jul 3 - Sun, Jul 5
American Airlines Logo
1:35 pm - 11:59 pm
DSM
-
LEX
9h 24m
2 stops
American Airlines Logo
8:10 pm - 12:09 am
LEX
-
DSM
4h 59m
1 stop
$363American Airlines
Fri, Jul 3 - Sun, Jul 5
American Airlines Logo
9:02 am - 7:40 pm
DSM
-
LEX
9h 38m
2 stops
American Airlines Logo
5:00 am - 1:05 pm
LEX
-
DSM
9h 05m
2 stops
$369American Airlines
Fri, Jul 3 - Sun, Jul 5
American Airlines Logo
10:35 am - 5:31 pm
DSM
-
LEX
5h 56m
1 stop
American Airlines Logo
6:00 am - 1:59 pm
LEX
-
DSM
8h 59m
2 stops
$382American Airlines
Sat, Sep 12 - Tue, Sep 15
Delta Logo
5:40 am - 12:11 pm
DSM
-
LEX
5h 31m
1 stop
Delta Logo
6:00 am - 10:43 am
LEX
-
DSM
5h 43m
1 stop
$384Delta
Fri, Aug 7 - Sun, Aug 9

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American Airlines flights from Des Moines to Lexington

Our best American Airlines deals on Des Moines to Lexington flight tickets
American Airlines
Aug 4
DSM7:04 amDes Moines
4h 30m
1 stop
LEX12:34 pmLexington Blue Grass
Aug 11
LEX8:05 amLexington Blue Grass
5h 19m
1 stop
DSM12:24 pmDes Moines
$308
American Airlines
Aug 29
DSM7:00 amDes Moines
10h 43m
2 stops
LEX6:43 pmLexington Blue Grass
Sep 2
LEX6:34 amLexington Blue Grass
4h 26m
1 stop
DSM10:00 amDes Moines
$314
American Airlines
Aug 29
DSM7:00 amDes Moines
10h 43m
2 stops
LEX6:43 pmLexington Blue Grass
Sep 2
LEX5:00 pmLexington Blue Grass
8h 20m
2 stops
DSM12:20 amDes Moines
$353

Delta flights from Des Moines to Lexington

Our best Delta deals on Des Moines to Lexington flight tickets
Delta
Jul 15
DSM2:25 pmDes Moines
6h 39m
1 stop
LEX10:04 pmLexington Blue Grass
Jul 18
LEX5:55 pmLexington Blue Grass
3h 54m
1 stop
DSM8:49 pmDes Moines
$309
Delta
Jul 4
DSM4:52 pmDes Moines
6h 12m
1 stop
LEX12:04 amLexington Blue Grass
Jul 10
LEX7:05 amLexington Blue Grass
4h 40m
1 stop
DSM10:45 amDes Moines
$324
Delta
Aug 7
DSM5:40 amDes Moines
5h 31m
1 stop
LEX12:11 pmLexington Blue Grass
Aug 9
LEX6:00 amLexington Blue Grass
5h 43m
1 stop
DSM10:43 amDes Moines
$384

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 8/4

7:04 am-12:34 pm

1 stop4h 30m

Lexington Blue Grass

Tue 8/11

8:05 am-12:24 pm

1 stop5h 19m

$308

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 7/17

5:00 am-10:50 am

1 stop4h 50m

Lexington Blue Grass

Fri 7/24

8:10 pm-12:09 am

1 stop4h 59m

$309

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 8/29

7:00 am-6:43 pm

2 stops10h 43m

Lexington Blue Grass

Wed 9/2

6:34 am-10:00 am

1 stop4h 26m

$314

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 7/4

4:52 pm-12:04 am

1 stop6h 12m

Lexington Blue Grass

Fri 7/10

7:05 am-10:45 am

1 stop4h 40m

$324

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 8/29

7:00 am-6:43 pm

2 stops10h 43m

Lexington Blue Grass

Wed 9/2

5:00 pm-12:20 am

2 stops8h 20m

$353
Quickest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 7/3

5:00 am-10:50 am

1 stop4h 50m

Lexington Blue Grass

Sun 7/5

5:35 am-8:23 am

1 stop3h 48m

$358

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 7/3

1:35 pm-11:59 pm

2 stops9h 24m

Lexington Blue Grass

Sun 7/5

8:10 pm-12:09 am

1 stop4h 59m

$363

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 7/3

9:02 am-7:40 pm

2 stops9h 38m

Lexington Blue Grass

Sun 7/5

5:00 am-1:05 pm

2 stops9h 05m

$369

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 9/12

10:35 am-5:31 pm

1 stop5h 56m

Lexington Blue Grass

Tue 9/15

6:00 am-1:59 pm

2 stops8h 59m

$382

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 8/7

5:40 am-12:11 pm

1 stop5h 31m

Lexington Blue Grass

Sun 8/9

6:00 am-10:43 am

1 stop5h 43m

$384

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Lexington from

How to get the cheapest flight ticket from Des Moines to Lexington

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Lexington?

What is the cheapest month to fly to Lexington?

In general, August is the cheapest month to fly from Des Moines to Lexington. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you are unable to visit Lexington during the month of August, then departing from Des Moines during the month January is also very affordable. Most momondo users find prices during this month for around $0.

When to book flights from Des Moines to Lexington

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Lexington according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Lexington (DSM to LEX) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Lexington

Fastest flight time

4h 18m

Direct flights

None
The fastest flight from Des Moines to Lexington takes 4h 18m
There are no direct flights from Des Moines to Lexington. There are no popular flight routes from Des Moines to Lexington.
Search flight deals

Frequently asked questions about flying from Des Moines to Lexington

  • How far is Des Moines to Lexington Blue Grass by plane?

    Des Moines and Lexington Blue Grass are 542.1 mi apart from one another. A reasonable flight in good conditions will take 4h 18m.

  • When did momondo last update prices for flights from Des Moines Airport to Lexington Blue Grass Airport?

    Prices for flights from Des Moines Airport to Lexington Blue Grass Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Lexington Blue Grass Airport?

  • How old do you have to be to fly from Des Moines Airport to Lexington Blue Grass Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Lexington Blue Grass Airport.

  • What documentation or ID do you need to fly to Lexington Blue Grass Airport?

    The necessary travel and health documents for your Lexington Blue Grass Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Lexington?

Best airlines flying from Des Moines to Lexington

Compare and see reviews for airlines that fly from Des Moines to Lexington with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,722 reviews
Search American Airlines flights
United AirlinesPriceFrom $308Free CancellationRating
7.4
9,868 reviews
Search United Airlines flights

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Richmond
Georgetown
Somerset
Frankfort
Danville
Winchester
Berea
Versailles
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Lexington?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Lexington from Des Moines.

Can I find flights from Des Moines to Lexington with flexible booking policies on momondo?

Flights from Des Moines to Lexington with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Lexington?

momondo helps you find the best flight between Des Moines and Lexington by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Lexington right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Lexington, momondo offers a useful price alert feature which will track prices for flights to Lexington from Des Moines and alert you when they change.

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