Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Lexington from $295

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Lexington departing on 1/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to Lexington

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
10:21 am - 4:55 pm
DSM
-
LEX
5h 34m
1 stop
Delta Logo
6:00 am - 10:41 am
LEX
-
DSM
5h 41m
1 stop
$329Delta
Thu, Jan 22 - Sun, Jan 25
American Airlines Logo
7:00 am - 3:37 pm
DSM
-
LEX
7h 37m
2 stops
American Airlines Logo
7:17 pm - 11:08 pm
LEX
-
DSM
4h 51m
1 stop
$340American Airlines
Thu, Jan 22 - Sun, Jan 25
American Airlines Logo
2:18 pm - 11:52 pm
DSM
-
LEX
8h 34m
2 stops
American Airlines Logo
6:00 am - 1:48 pm
LEX
-
DSM
8h 48m
2 stops
$359American Airlines
Wed, Apr 29 - Sun, May 3
United Airlines Logo
3:35 pm - 10:40 pm
DSM
-
LEX
6h 05m
1 stop
United Airlines Logo
10:30 am - 2:33 pm
LEX
-
DSM
5h 03m
1 stop
$379United Airlines
Thu, Jan 22 - Sun, Jan 25
American Airlines Logo
2:02 pm - 10:46 pm
DSM
-
LEX
7h 44m
1 stop
American Airlines Logo
6:00 am - 1:48 pm
LEX
-
DSM
8h 48m
2 stops
$384American Airlines
Wed, Apr 29 - Sun, May 3
American Airlines Logo
2:02 pm - 10:46 pm
DSM
-
LEX
7h 44m
1 stop
American Airlines Logo
8:00 am - 1:48 pm
LEX
-
DSM
6h 48m
1 stop
$458American Airlines
Wed, Apr 29 - Sun, May 3
American Airlines Logo
7:00 am - 5:53 pm
DSM
-
LEX
9h 53m
2 stops
American Airlines Logo
6:00 am - 4:24 pm
LEX
-
DSM
11h 24m
2 stops
$528American Airlines
Thu, Jan 22 - Sun, Jan 25

United Airlines flights from Des Moines to Lexington

Our best United Airlines deals on Des Moines to Lexington flight tickets
United Airlines
Jan 22
DSM3:35 pmDes Moines
6h 05m
1 stop
LEX10:40 pmLexington Blue Grass
Jan 25
LEX10:30 amLexington Blue Grass
5h 03m
1 stop
DSM2:33 pmDes Moines
$379
United Airlines
Jan 20
DSM11:30 amDes Moines
4h 18m
1 stop
LEX4:48 pmLexington Blue Grass
Jan 24
LEX8:35 amLexington Blue Grass
6h 58m
1 stop
DSM2:33 pmDes Moines
$409
United Airlines
Jan 20
DSM3:04 pmDes Moines
21h 21m
2 stops
LEX1:25 pmLexington Blue Grass
Jan 24
LEX9:00 amLexington Blue Grass
8h 28m
1 stop
DSM4:28 pmDes Moines
$563

American Airlines flights from Des Moines to Lexington

Our best American Airlines deals on Des Moines to Lexington flight tickets
American Airlines
Jan 22
DSM7:00 amDes Moines
7h 37m
2 stops
LEX3:37 pmLexington Blue Grass
Jan 25
LEX7:17 pmLexington Blue Grass
4h 51m
1 stop
DSM11:08 pmDes Moines
$340
American Airlines
Apr 29
DSM2:18 pmDes Moines
8h 34m
2 stops
LEX11:52 pmLexington Blue Grass
May 3
LEX6:00 amLexington Blue Grass
8h 48m
2 stops
DSM1:48 pmDes Moines
$359
American Airlines
Apr 29
DSM2:02 pmDes Moines
7h 44m
1 stop
LEX10:46 pmLexington Blue Grass
May 3
LEX6:00 amLexington Blue Grass
8h 48m
2 stops
DSM1:48 pmDes Moines
$384

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 1/22

10:21 am-4:55 pm

1 stop5h 34m

Lexington Blue Grass

Sun 1/25

6:00 am-10:41 am

1 stop5h 41m

$329

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 1/22

7:00 am-3:37 pm

2 stops7h 37m

Lexington Blue Grass

Sun 1/25

7:17 pm-11:08 pm

1 stop4h 51m

$340

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 4/29

2:18 pm-11:52 pm

2 stops8h 34m

Lexington Blue Grass

Sun 5/3

6:00 am-1:48 pm

2 stops8h 48m

$359

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 1/22

3:35 pm-10:40 pm

1 stop6h 05m

Lexington Blue Grass

Sun 1/25

10:30 am-2:33 pm

1 stop5h 03m

$379

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 4/29

2:02 pm-10:46 pm

1 stop7h 44m

Lexington Blue Grass

Sun 5/3

6:00 am-1:48 pm

2 stops8h 48m

$384

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 4/29

2:02 pm-10:46 pm

1 stop7h 44m

Lexington Blue Grass

Sun 5/3

8:00 am-1:48 pm

1 stop6h 48m

$458

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 1/22

7:00 am-5:53 pm

2 stops9h 53m

Lexington Blue Grass

Sun 1/25

6:00 am-4:24 pm

2 stops11h 24m

$528

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 1/17

5:58 pm-8:51 pm

1 stop25h 53m

$295

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 1/17

11:42 am-11:36 pm

2 stops10h 54m

$369

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 1/17

5:58 pm-8:44 am

3 stops37h 46m

$500

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Lexington from

How to get the cheapest flight ticket from Des Moines to Lexington

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Lexington Blue Grass?

Allegiant Air and American Airlines are the most popular carriers operating from Des Moines to Lexington Blue Grass

What airlines fly to Lexington?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Lexington from Des Moines according to our data. United Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Lexington. Keep in mind that there are 3 different airlines that fly to Lexington on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Lexington

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Lexington according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Lexington (DSM to LEX) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Lexington

Fastest flight time

4h 03m

Direct flights

None
The fastest flight from Des Moines to Lexington takes 4h 03m
There are no direct flights from Des Moines to Lexington. There are no popular flight routes from Des Moines to Lexington.
Search flight deals

  • How far is Des Moines to Lexington Blue Grass by plane?

    Des Moines and Lexington Blue Grass are 542.1 mi apart from one another. A reasonable flight in good conditions will take 4h 03m.

  • When did momondo last update prices for flights from Des Moines Airport to Lexington Blue Grass Airport?

    Prices for flights from Des Moines Airport to Lexington Blue Grass Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Lexington Blue Grass Airport?

  • How old do you have to be to fly from Des Moines Airport to Lexington Blue Grass Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Lexington Blue Grass Airport.

  • What documentation or ID do you need to fly to Lexington Blue Grass Airport?

    The necessary travel and health documents for your Lexington Blue Grass Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Lexington?

Best airlines flying from Des Moines to Lexington

Compare and see reviews for airlines that fly from Des Moines to Lexington with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $225Free CancellationRating
7.4
9,149 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,114 reviews
Search American Airlines flights

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Richmond
Somerset
Georgetown
Danville
Frankfort
Winchester
Berea
Carlisle
Versailles

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Lexington?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Lexington from Des Moines.

Can I find flights from Des Moines to Lexington with flexible booking policies on momondo?

Flights from Des Moines to Lexington with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Lexington?

momondo helps you find the best flight between Des Moines and Lexington by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Lexington right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Lexington, momondo offers a useful price alert feature which will track prices for flights to Lexington from Des Moines and alert you when they change.

An easier way to manage your Lexington trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 2/11
Wed 2/18
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States