What airlines fly to Florida Keys?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Florida Keys from Des Moines according to our data. American Airlines is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 4 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

How many flights depart from Des Moines to Florida Keys on average per week?

As of March 2026, 14 flights take off from Des Moines and land in Florida Keys each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.

What is the cheapest airline that flies from Des Moines to Florida Keys?

United Airlines, American Airlines, and Southwest are the most popular carriers operating from Des Moines to Florida Keys

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

The number of operators available for flights from Des Moines Airport to Florida Keys is 5 as of March 2026.

How old do you have to be to fly from Des Moines Airport to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$75 Cheap Flights from Des Moines to Florida Keys in 2026

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Find the cheapest flights from Des Moines to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:48 pm - 8:57 pm

DSM

MIA

6h 09m

1 stop

9:05 pm - 11:56 pm

MIA

DSM

3h 51mnonstop

$149American Airlines

Wed, Apr 1 - Mon, Apr 6

11:09 am - 7:24 pm

DSM

MIA

7h 15m

1 stop

6:55 pm - 11:49 pm

MIA

DSM

5h 54m

1 stop

$158American Airlines

Wed, Apr 15 - Wed, Apr 22

5:30 am - 11:55 am

DSM

MIA

5h 25m

1 stop

6:40 am - 11:25 am

MIA

DSM

5h 45m

1 stop

$159Southwest

Wed, Apr 15 - Wed, Apr 22

2:16 pm - 9:37 pm

DSM

MIA

6h 21m

1 stop

4:31 pm - 9:53 pm

MIA

DSM

6h 22m

1 stop

$160American Airlines

Mon, Apr 13 - Thu, Apr 16

5:30 am - 11:55 am

DSM

MIA

5h 25m

1 stop

12:10 pm - 9:15 pm

MIA

DSM

10h 05m

2 stops

$164Southwest

Wed, Apr 15 - Wed, Apr 22

8:14 pm - 5:49 am

DSM

MIA

8h 35m

1 stop

7:00 am - 1:09 pm

MIA

DSM

7h 09m

1 stop

$190Frontier

Mon, Apr 13 - Fri, Apr 17

8:14 pm - 5:49 am

DSM

MIA

8h 35m

1 stop

7:00 am - 1:09 pm

MIA

DSM

31h 09m

1 stop

$210Frontier

Mon, Apr 13 - Thu, Apr 16

4:22 pm - 3:12 pm

DSM

EYW

21h 50m

1 stop

2:48 pm - 10:52 pm

EYW

DSM

9h 04m

1 stop

$263Allegiant Air

Sat, Jun 20 - Sat, Jun 27

4:22 pm - 3:12 pm

DSM

EYW

21h 50m

1 stop

2:48 pm - 10:52 pm

EYW

DSM

9h 04m

1 stop

$297Allegiant Air

Sat, Jun 20 - Sat, Jun 27

5:35 am - 1:43 pm

DSM

EYW

7h 08m

1 stop

6:25 pm - 10:38 pm

EYW

DSM

5h 13m

1 stop

$314Delta

Wed, Mar 18 - Wed, Mar 25

Frontier flights from Des Moines to Florida Keys

Our best Frontier deals on Des Moines to Florida Keys flight tickets

Frontier

Apr 13

DSM8:14 pmDes Moines

8h 35m

1 stop

MIA5:49 amMiami

Apr 17

MIA7:00 amMiami

7h 09m

1 stop

DSM1:09 pmDes Moines

$190

Frontier

Apr 13

DSM8:14 pmDes Moines

8h 35m

1 stop

MIA5:49 amMiami

Apr 16

MIA7:00 amMiami

31h 09m

1 stop

DSM1:09 pmDes Moines

$210

Frontier

Apr 24

DSM2:04 pmDes Moines

14h 01m

1 stop

MIA5:05 amMiami

Apr 27

MIA7:00 amMiami

7h 09m

1 stop

DSM1:09 pmDes Moines

$211

Delta flights from Des Moines to Florida Keys

Our best Delta deals on Des Moines to Florida Keys flight tickets

Delta

Apr 14

DSM6:31 pmDes Moines

5h 23m

1 stop

MIA12:54 amMiami

Apr 16

MIA6:00 amMiami

6h 05m

1 stop

DSM11:05 amDes Moines

$217

Delta

Mar 18

DSM5:35 amDes Moines

7h 08m

1 stop

EYW1:43 pmKey West

Mar 25

EYW6:25 pmKey West

5h 13m

1 stop

DSM10:38 pmDes Moines

$314

Delta

Apr 13

DSM6:31 pmDes Moines

14h 52m

2 stops

MIA10:23 amMiami

Apr 18

MIA7:04 amMiami

5h 01m

1 stop

DSM11:05 amDes Moines

$317

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 4/1

1:48 pm-8:57 pm

1 stop6h 09m

Miami

Mon 4/6

9:05 pm-11:56 pm

Nonstop3h 51m

$149

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 4/15

11:09 am-7:24 pm

1 stop7h 15m

Miami

Wed 4/22

6:55 pm-11:49 pm

1 stop5h 54m

$158

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 4/15

5:30 am-11:55 am

1 stop5h 25m

Miami

Wed 4/22

6:40 am-11:25 am

1 stop5h 45m

$159

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 4/13

2:16 pm-9:37 pm

1 stop6h 21m

Miami

Thu 4/16

4:31 pm-9:53 pm

1 stop6h 22m

$160

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 4/15

5:30 am-11:55 am

1 stop5h 25m

Miami

Wed 4/22

12:10 pm-9:15 pm

2 stops10h 05m

$164

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 4/13

8:14 pm-5:49 am

1 stop8h 35m

Miami

Fri 4/17

7:00 am-1:09 pm

1 stop7h 09m

$190

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 4/13

8:14 pm-5:49 am

1 stop8h 35m

Miami

Thu 4/16

7:00 am-1:09 pm

1 stop31h 09m

$210

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 6/20

4:22 pm-3:12 pm

1 stop21h 50m

Key West

Sat 6/27

2:48 pm-10:52 pm

1 stop9h 04m

$263

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 6/20

4:22 pm-3:12 pm

1 stop21h 50m

Key West

Sat 6/27

2:48 pm-10:52 pm

1 stop9h 04m

$297

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/18

5:35 am-1:43 pm

1 stop7h 08m

Key West

Wed 3/25

6:25 pm-10:38 pm

1 stop5h 13m

$314

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Florida Keys?

The month of June is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $336.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $568. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $680.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $407 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $332 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time	3h 20m
Direct flights	Every day
Airports in Florida Keys	3 airports

The fastest flight from Des Moines to Florida Keys takes 3h 20m

Direct flights go from Des Moines to Florida Keys every day.

There are 3 airports in Florida Keys. From Des Moines there are direct flights to Miami (MIA).

Search flight deals

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?
Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Florida Keys?
The number of operators available for flights from Des Moines Airport to Florida Keys is 5 as of March 2026.
How old do you have to be to fly from Des Moines Airport to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Des Moines to Florida Keys?
momondo data reveals that the most frequently booked plane model on the route from Des Moines to Florida Keys is Airbus A320-100/200, representing 25.04% of all bookings. The subsequent popular models are Airbus A319 at 15.92%, Embraer 175 at 13.69%, and Boeing 737 MAX 8 at 9.48%.

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.3 714 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.1 11,375 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,242 reviews	Search Delta flights
United Airlines	PriceFrom $288	Free Cancellation	Rating 7.4 9,378 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.