What is the cheapest airline that flies from Des Moines to Florida Keys?

Frontier, Delta, and United Airlines are the most popular carriers operating from Des Moines to Florida Keys

How many flights depart from Des Moines to Florida Keys on average per week?

As of January 2026, 14 flights take off from Des Moines and land in Florida Keys each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.

What airlines fly to Florida Keys?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Florida Keys from Des Moines according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 4 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

The number of operators available for flights from Des Moines Airport to Florida Keys is 5 as of January 2026.

How old do you have to be to fly from Des Moines Airport to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$98 Cheap Flights from Des Moines to Florida Keys in 2026

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Find the cheapest flights from Des Moines to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:45 pm - 5:14 am

DSM

MIA

8h 29m

1 stop

6:45 am - 6:42 pm

MIA

DSM

12h 57m

1 stop

$215Frontier

Sun, Feb 22 - Thu, Feb 26

7:27 pm - 5:14 am

DSM

MIA

8h 47m

1 stop

6:45 am - 6:42 pm

MIA

DSM

12h 57m

1 stop

$220Frontier

Thu, Feb 26 - Thu, Mar 5

7:17 pm - 10:28 am

DSM

MIA

14h 11m

2 stops

5:50 am - 7:16 pm

MIA

DSM

14h 26m

1 stop

$223Frontier

Mon, Mar 2 - Mon, Mar 9

7:59 pm - 10:23 am

DSM

MIA

37h 24m

2 stops

5:50 am - 7:16 pm

MIA

DSM

14h 26m

1 stop

$225Frontier

Fri, Feb 27 - Sat, Mar 7

7:17 pm - 12:42 am

DSM

MIA

28h 25m

2 stops

5:50 am - 7:16 pm

MIA

DSM

14h 26m

1 stop

$230Frontier

Mon, Mar 2 - Mon, Mar 9

5:00 am - 2:06 pm

DSM

MIA

8h 06m

1 stop

9:08 pm - 11:59 pm

MIA

DSM

3h 51mnonstop

$247American Airlines

Wed, Feb 18 - Wed, Feb 25

1:52 pm - 10:37 pm

DSM

EYW

7h 45m

1 stop

4:40 pm - 9:59 pm

EYW

DSM

6h 19m

1 stop

$289American Airlines

Wed, Mar 25 - Wed, Apr 1

6:00 am - 3:21 pm

DSM

EYW

8h 21m

1 stop

1:55 pm - 11:40 pm

EYW

DSM

10h 45m

2 stops

$294American Airlines

Tue, Feb 17 - Tue, Feb 24

5:03 pm - 9:37 pm

DSM

EYW

27h 34m

1 stop

1:01 pm - 9:31 am

EYW

DSM

21h 30m

1 stop

$298Multiple Airlines

Sat, Mar 21 - Tue, Mar 31

6:00 am - 4:49 pm

DSM

EYW

9h 49m

2 stops

1:55 pm - 10:19 pm

EYW

DSM

9h 24m

2 stops

$300American Airlines

Tue, Feb 17 - Tue, Feb 24

American Airlines flights from Des Moines to Florida Keys

Our best American Airlines deals on Des Moines to Florida Keys flight tickets

American Airlines

Feb 18

DSM5:00 amDes Moines

8h 06m

1 stop

MIA2:06 pmMiami

Feb 25

MIA9:08 pmMiami

3h 51m

DSM11:59 pmDes Moines

$247

American Airlines

Mar 4

DSM1:48 pmDes Moines

6h 09m

1 stop

MIA8:57 pmMiami

Mar 11

MIA9:05 pmMiami

3h 51m

DSM11:56 pmDes Moines

$248

American Airlines

Mar 25

DSM1:52 pmDes Moines

7h 45m

1 stop

EYW10:37 pmKey West

Apr 1

EYW4:40 pmKey West

6h 19m

1 stop

DSM9:59 pmDes Moines

$289

Southwest flights from Des Moines to Florida Keys

Our best Southwest deals on Des Moines to Florida Keys flight tickets

Southwest

Feb 10

DSM8:35 amDes Moines

6h 55m

1 stop

MIA4:30 pmMiami

Feb 17

MIA5:50 pmMiami

5h 25m

1 stop

DSM10:15 pmDes Moines

$249

Southwest

Feb 17

DSM5:20 amDes Moines

5h 10m

1 stop

MIA11:30 amMiami

Feb 24

MIA12:00 pmMiami

10h 10m

2 stops

DSM9:10 pmDes Moines

$252

Southwest

Feb 18

DSM6:10 amDes Moines

11h 25m

2 stops

MIA6:35 pmMiami

Feb 25

MIA12:55 pmMiami

9h 15m

2 stops

DSM9:10 pmDes Moines

$265

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 2/22

7:45 pm-5:14 am

1 stop8h 29m

Miami

Thu 2/26

6:45 am-6:42 pm

1 stop12h 57m

$215

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 2/26

7:27 pm-5:14 am

1 stop8h 47m

Miami

Thu 3/5

6:45 am-6:42 pm

1 stop12h 57m

$220

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 3/2

7:17 pm-10:28 am

2 stops14h 11m

Miami

Mon 3/9

5:50 am-7:16 pm

1 stop14h 26m

$223

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 2/27

7:59 pm-10:23 am

2 stops37h 24m

Miami

Sat 3/7

5:50 am-7:16 pm

1 stop14h 26m

$225

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 3/2

7:17 pm-12:42 am

2 stops28h 25m

Miami

Mon 3/9

5:50 am-7:16 pm

1 stop14h 26m

$230

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 2/18

5:00 am-2:06 pm

1 stop8h 06m

Miami

Wed 2/25

9:08 pm-11:59 pm

Nonstop3h 51m

$247

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/25

1:52 pm-10:37 pm

1 stop7h 45m

Key West

Wed 4/1

4:40 pm-9:59 pm

1 stop6h 19m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

6:00 am-3:21 pm

1 stop8h 21m

Key West

Tue 2/24

1:55 pm-11:40 pm

2 stops10h 45m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 3/21

5:03 pm-9:37 pm

1 stop27h 34m

Key West

Tue 3/31

1:01 pm-9:31 am

1 stop21h 30m

$298

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

6:00 am-4:49 pm

2 stops9h 49m

Key West

Tue 2/24

1:55 pm-10:19 pm

2 stops9h 24m

$300

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Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Florida Keys?

The month of December is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $317.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $568. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $701.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $406 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $336 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time	3h 20m
Direct flights	Every day
Airports in Florida Keys	3 airports

The fastest flight from Des Moines to Florida Keys takes 3h 20m

Direct flights go from Des Moines to Florida Keys every day.

There are 3 airports in Florida Keys. From Des Moines there are direct flights to Miami (MIA).

Search flight deals

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?
Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Florida Keys?
The number of operators available for flights from Des Moines Airport to Florida Keys is 5 as of January 2026.
How old do you have to be to fly from Des Moines Airport to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Des Moines to Florida Keys?
momondo data reveals that the most frequently booked plane model on the route from Des Moines to Florida Keys is Airbus A320-100/200, representing 24.67% of all bookings. The subsequent popular models are Airbus A319 at 15.19%, Embraer 175 at 13.15%, and Boeing 737 MAX 8 at 9.83%.

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.2 705 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.2 11,163 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,080 reviews	Search Delta flights
United Airlines	PriceFrom $281	Free Cancellation	Rating 7.4 9,183 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florida Keys trip

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Find better results for your trip to Florida Keys

Popular cities in Florida Keys

Flights to New Yorkfrom $49

Flights to Los Angelesfrom $46

Flights to Miamifrom $34

Flights to Chicagofrom $57

Flights to Orlandofrom $49

Flights to San Franciscofrom $48

Flights to Las Vegasfrom $46

Flights to Washington, D.C.from $52

Flights to Bostonfrom $59

Flights to Atlantafrom $49

Flights to Dallasfrom $62

Flights to Seattlefrom $56

Cheap flights from Des Moines to Florida Keys from $98

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florida Keys departing on 2/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Filter for what you want

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American Airlines flights from Des Moines to Florida Keys

Our best American Airlines deals on Des Moines to Florida Keys flight tickets

Southwest flights from Des Moines to Florida Keys

Our best Southwest deals on Des Moines to Florida Keys flight tickets

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Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

See travel insights to Florida Keys from

How to get the cheapest flight ticket from Des Moines to Florida Keys

What is the cheapest month to fly to Florida Keys?

The month of December is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $317.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $568. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $701.

How far in advance should I book a flight to Florida Keys?

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

What is the cheapest airline that flies from Des Moines to Florida Keys?

Frontier, Delta, and United Airlines are the most popular carriers operating from Des Moines to Florida Keys

What airlines fly to Florida Keys?

How many flights depart from Des Moines to Florida Keys on average per week?

As of January 2026, 14 flights take off from Des Moines and land in Florida Keys each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time

Direct flights

Airports in Florida Keys

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

How old do you have to be to fly from Des Moines Airport to Florida Keys?

What documentation or ID do you need to fly to Florida Keys?

What is the most popular plane model from Des Moines to Florida Keys?

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to Florida Keys?

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

An easier way to manage your Florida Keys trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Florida Keys

Popular cities in Florida Keys

Popular flights according to clicks in the last 7 days on momondo