How many flights depart from Des Moines to Florida Keys on average per week?

As of July 2026, 2 flights take off from Des Moines and land in Florida Keys each week. The most common flight departure day for this route is Sat, with 100% of weekly flights taking off on this day.

What is the cheapest airline that flies from Des Moines to Florida Keys?

Frontier, United Airlines, and Southwest are the most popular carriers operating from Des Moines to Florida Keys

What airlines fly to Florida Keys?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Florida Keys from Des Moines according to our data. American Airlines is the first choice among our users, with 68% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 3 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

The number of operators available for flights from Des Moines Airport to Florida Keys is 5 as of July 2026.

How old do you have to be to fly from Des Moines Airport to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$112 Cheap Flights from Des Moines to Florida Keys in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:55 pm - 4:21 pm

DSM

MIA

25h 26m

2 stops

9:35 am - 7:54 pm

MIA

DSM

11h 19m

1 stop

$231Multiple Airlines

Thu, Aug 20 - Thu, Aug 27

1:55 pm - 11:05 pm

DSM

MIA

32h 10m

2 stops

9:35 am - 7:54 pm

MIA

DSM

11h 19m

1 stop

$251Multiple Airlines

Thu, Aug 20 - Thu, Aug 27

2:19 pm - 4:52 am

DSM

MIA

13h 33m

1 stop

5:50 am - 7:33 pm

MIA

DSM

14h 43m

1 stop

$279Frontier

Mon, Sep 7 - Mon, Sep 14

2:19 pm - 4:52 am

DSM

MIA

13h 33m

1 stop

7:20 am - 1:56 pm

MIA

DSM

7h 36m

1 stop

$280Frontier

Mon, Sep 7 - Mon, Sep 14

2:19 pm - 4:52 am

DSM

MIA

13h 33m

1 stop

7:20 am - 1:56 pm

MIA

DSM

7h 36m

1 stop

$281Frontier

Mon, Sep 7 - Mon, Sep 14

10:04 am - 3:02 pm

DSM

EYW

27h 58m

1 stop

12:07 pm - 9:26 pm

EYW

DSM

10h 19m

1 stop

$300Multiple Airlines

Fri, Aug 21 - Fri, Aug 28

2:08 pm - 9:45 pm

DSM

EYW

6h 37m

1 stop

4:10 pm - 11:29 pm

EYW

DSM

8h 19m

1 stop

$309American Airlines

Sat, Dec 5 - Wed, Dec 9

8:10 am - 4:18 pm

DSM

EYW

7h 08m

1 stop

1:50 pm - 6:41 pm

EYW

DSM

5h 51m

1 stop

$314American Airlines

Fri, Aug 28 - Tue, Sep 1

2:08 pm - 9:45 pm

DSM

EYW

6h 37m

1 stop

4:10 pm - 11:29 pm

EYW

DSM

8h 19m

1 stop

$319American Airlines

Sat, Dec 5 - Wed, Dec 9

11:28 am - 6:45 pm

DSM

EYW

6h 17m

1 stop

5:01 pm - 12:14 am

EYW

DSM

8h 13m

1 stop

$329American Airlines

Fri, Nov 13 - Mon, Nov 16

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Frontier flights from Des Moines to Florida Keys

Our best Frontier deals on Des Moines to Florida Keys flight tickets

Frontier

Sep 7

DSM2:19 pmDes Moines

13h 33m

1 stop

MIA4:52 amMiami

Sep 14

MIA5:50 amMiami

14h 43m

1 stop

DSM7:33 pmDes Moines

$279

Frontier

Sep 7

DSM2:19 pmDes Moines

13h 33m

1 stop

MIA4:52 amMiami

Sep 14

MIA7:20 amMiami

7h 36m

1 stop

DSM1:56 pmDes Moines

$280

Frontier

Sep 7

DSM2:19 pmDes Moines

13h 33m

1 stop

MIA4:52 amMiami

Sep 14

MIA7:20 amMiami

7h 36m

1 stop

DSM1:56 pmDes Moines

$281

United Airlines flights from Des Moines to Florida Keys

Our best United Airlines deals on Des Moines to Florida Keys flight tickets

United Airlines

Jan 6

DSM8:00 amDes Moines

6h 06m

1 stop

EYW3:06 pmKey West

Jan 13

EYW4:05 pmKey West

7h 56m

1 stop

DSM11:01 pmDes Moines

$389

United Airlines

Aug 6

DSM6:00 amDes Moines

7h 57m

1 stop

MIA2:57 pmMiami

Aug 10

MIA4:10 pmMiami

7h 46m

1 stop

DSM10:56 pmDes Moines

$517

United Airlines

Jul 26

DSM8:00 amDes Moines

5h 57m

1 stop

MIA2:57 pmMiami

Jul 28

MIA4:10 pmMiami

6h 12m

1 stop

DSM9:22 pmDes Moines

$525

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 8/20

1:55 pm-4:21 pm

2 stops25h 26m

Miami

Thu 8/27

9:35 am-7:54 pm

1 stop11h 19m

$231

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 8/20

1:55 pm-11:05 pm

2 stops32h 10m

Miami

Thu 8/27

9:35 am-7:54 pm

1 stop11h 19m

$251

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 9/7

2:19 pm-4:52 am

1 stop13h 33m

Miami

Mon 9/14

5:50 am-7:33 pm

1 stop14h 43m

$279

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 9/7

2:19 pm-4:52 am

1 stop13h 33m

Miami

Mon 9/14

7:20 am-1:56 pm

1 stop7h 36m

$280

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 9/7

2:19 pm-4:52 am

1 stop13h 33m

Miami

Mon 9/14

7:20 am-1:56 pm

1 stop7h 36m

$281

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 8/21

10:04 am-3:02 pm

1 stop27h 58m

Key West

Fri 8/28

12:07 pm-9:26 pm

1 stop10h 19m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/5

2:08 pm-9:45 pm

1 stop6h 37m

Key West

Wed 12/9

4:10 pm-11:29 pm

1 stop8h 19m

$309

Quickest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 8/28

8:10 am-4:18 pm

1 stop7h 08m

Key West

Tue 9/1

1:50 pm-6:41 pm

1 stop5h 51m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/5

2:08 pm-9:45 pm

1 stop6h 37m

Key West

Wed 12/9

4:10 pm-11:29 pm

1 stop8h 19m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 11/13

11:28 am-6:45 pm

1 stop6h 17m

Key West

Mon 11/16

5:01 pm-12:14 am

1 stop8h 13m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Florida Keys?

The month of September is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $378.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $621. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $703.

How far in advance should I book a flight from Des Moines to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $415 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $309 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time	3h 22m
Direct flights	Every day
Airports in Florida Keys	3 airports

The fastest flight from Des Moines to Florida Keys takes 3h 22m

Direct flights go from Des Moines to Florida Keys every day.

There are 3 airports in Florida Keys. From Des Moines there are direct flights to Miami (MIA).

Search flight deals

Frequently asked questions about flying from Des Moines to Florida Keys

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?
Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Florida Keys?
The number of operators available for flights from Des Moines Airport to Florida Keys is 5 as of July 2026.
How old do you have to be to fly from Des Moines Airport to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Des Moines to Florida Keys?
momondo data reveals that the most frequently booked plane model on the route from Des Moines to Florida Keys is Airbus A320-100/200, representing 22.76% of all bookings. The subsequent popular models are Airbus A319 at 14.73%, Embraer 175 at 12.36%, and Embraer 175 (Enhanced Winglets) at 8.93%.

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $268	Free Cancellation	Rating 7.4 10,034 reviews	Search United Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.8 8,486 reviews	Search Delta flights
American Airlines	PriceFrom $279	Free Cancellation	Rating 7.1 11,848 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.