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Cheap flights from Des Moines to Florida Keys from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florida Keys departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Florida Keys

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:10 am - 12:00 pmDSM-MIA
4h 50m1 stop
Southwest Logo
4:55 pm - 9:10 pmMIA-DSM
5h 15m1 stop
$154Southwest
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Tue, Jan 20 - Tue, Jan 27
Southwest Logo
6:10 am - 12:00 pmDSM-MIA
4h 50m1 stop
Southwest Logo
12:55 pm - 9:10 pmMIA-DSM
9h 15m2 stops
$159Southwest
Find Deal
Tue, Jan 20 - Tue, Jan 27
Southwest Logo
6:10 am - 6:35 pmDSM-MIA
11h 25m2 stops
Southwest Logo
7:45 am - 7:15 pmMIA-DSM
12h 30m1 stop
$185Southwest
Find Deal
Wed, Feb 18 - Sat, Feb 21
Multiple Airlines Logo
6:14 pm - 9:37 pmDSM-EYW
26h 23m1 stop
Multiple Airlines Logo
12:51 pm - 10:46 pmEYW-DSM
10h 55m1 stop
$186Multiple Airlines
Find Deal
Wed, Jan 28 - Thu, Feb 5
Multiple Airlines Logo
2:58 pm - 1:30 pmDSM-EYW
21h 32m1 stop
Multiple Airlines Logo
12:15 pm - 11:12 pmEYW-DSM
11h 57m1 stop
$198Multiple Airlines
Find Deal
Sun, Feb 8 - Thu, Feb 12
Southwest Logo
6:10 am - 6:35 pmDSM-MIA
11h 25m2 stops
Southwest Logo
12:55 pm - 9:10 pmMIA-DSM
9h 15m2 stops
$198Southwest
Find Deal
Tue, Jan 20 - Tue, Jan 27
Delta Logo
5:16 pm - 12:51 amDSM-MIA
6h 35m1 stop
Delta Logo
7:15 am - 12:15 pmMIA-DSM
6h 00m1 stop
$207Delta
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Mon, Jan 19 - Sat, Jan 31
Delta Logo
10:59 am - 5:59 pmDSM-MIA
6h 00m1 stop
Delta Logo
8:15 am - 12:15 pmMIA-DSM
5h 00m1 stop
$217Delta
Find Deal
Mon, Jan 19 - Sat, Jan 31
American Airlines Logo
6:00 am - 4:07 pmDSM-EYW
9h 07m1 stop
American Airlines Logo
6:43 pm - 11:08 pmEYW-DSM
5h 25m1 stop
$219American Airlines
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Fri, Jan 9 - Wed, Jan 14
American Airlines Logo
11:42 am - 11:56 pmDSM-EYW
11h 14m2 stops
American Airlines Logo
1:22 pm - 10:11 pmEYW-DSM
9h 49m2 stops
$229American Airlines
Find Deal
Fri, Jan 9 - Wed, Jan 14

Southwest flights from Des Moines to Florida Keys

Our best Southwest deals on Des Moines to Florida Keys flight tickets
Southwest
Jan 20
DSM6:10 amDes Moines
4h 50m
1 stop
MIA12:00 pmMiami
Jan 27
MIA4:55 pmMiami
5h 15m
1 stop
DSM9:10 pmDes Moines
$154
Find similar
Southwest
Jan 20
DSM6:10 amDes Moines
4h 50m
1 stop
MIA12:00 pmMiami
Jan 27
MIA12:55 pmMiami
9h 15m
2 stops
DSM9:10 pmDes Moines
$159
Find similar
Southwest
Feb 18
DSM6:10 amDes Moines
11h 25m
2 stops
MIA6:35 pmMiami
Feb 21
MIA7:45 amMiami
12h 30m
1 stop
DSM7:15 pmDes Moines
$185
Find similar

Delta flights from Des Moines to Florida Keys

Our best Delta deals on Des Moines to Florida Keys flight tickets
Delta
Jan 19
DSM5:16 pmDes Moines
6h 35m
1 stop
MIA12:51 amMiami
Jan 31
MIA7:15 amMiami
6h 00m
1 stop
DSM12:15 pmDes Moines
$207
Find similar
Delta
Jan 19
DSM10:59 amDes Moines
6h 00m
1 stop
MIA5:59 pmMiami
Jan 31
MIA8:15 amMiami
5h 00m
1 stop
DSM12:15 pmDes Moines
$217
Find similar
Delta
Feb 4
DSM5:16 pmDes Moines
6h 35m
1 stop
MIA12:51 amMiami
Feb 10
MIA11:33 amMiami
9h 01m
1 stop
DSM7:34 pmDes Moines
$239
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 3, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 1/20

6:10 am-12:00 pm

1 stop4h 50m

Miami

Tue 1/27

4:55 pm-9:10 pm

1 stop5h 15m

$154

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 1/20

6:10 am-12:00 pm

1 stop4h 50m

Miami

Tue 1/27

12:55 pm-9:10 pm

2 stops9h 15m

$159

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 2/18

6:10 am-6:35 pm

2 stops11h 25m

Miami

Sat 2/21

7:45 am-7:15 pm

1 stop12h 30m

$185

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 1/28

6:14 pm-9:37 pm

1 stop26h 23m

Key West

Thu 2/5

12:51 pm-10:46 pm

1 stop10h 55m

$186

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 2/8

2:58 pm-1:30 pm

1 stop21h 32m

Key West

Thu 2/12

12:15 pm-11:12 pm

1 stop11h 57m

$198

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 1/20

6:10 am-6:35 pm

2 stops11h 25m

Miami

Tue 1/27

12:55 pm-9:10 pm

2 stops9h 15m

$198

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 1/19

5:16 pm-12:51 am

1 stop6h 35m

Miami

Sat 1/31

7:15 am-12:15 pm

1 stop6h 00m

$207

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 1/19

10:59 am-5:59 pm

1 stop6h 00m

Miami

Sat 1/31

8:15 am-12:15 pm

1 stop5h 00m

$217

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

6:00 am-4:07 pm

1 stop9h 07m

Key West

Wed 1/14

6:43 pm-11:08 pm

1 stop5h 25m

$219

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

11:42 am-11:56 pm

2 stops11h 14m

Key West

Wed 1/14

1:22 pm-10:11 pm

2 stops9h 49m

$229

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of August is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $355.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $519. The most expensive day to fly to Florida Keys is Saturday, with ticket prices averaging around $729.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the evening. momondo users have found flights departing from Des Moines to Florida Keys in the evening for as low as $278. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the morning are often more expensive with an average ticket price of $627.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $336 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time

3h 20m

Direct flights

Every day

Airports in Florida Keys

1 airport
The fastest flight from Des Moines to Florida Keys takes 3h 20m
Direct flights go from Des Moines to Florida Keys every day.
There is 1 airport near Florida Keys: Miami (MIA)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

    Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

  • How old do you have to be to fly from Des Moines Airport to Florida Keys?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to Florida Keys?

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
698 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,011 reviews
Search Delta flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
9,063 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florida Keys trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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