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Cheap flights from Des Moines to Florida Keys from $67

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florida Keys departing on 11/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Florida Keys

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:15 am - 12:25 pmDSM-MIA
5h 10m1 stop
Southwest Logo
4:55 pm - 9:35 pmMIA-DSM
5h 40m1 stop
$179Southwest
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Mon, Dec 8 - Wed, Dec 17
Southwest Logo
6:15 am - 4:10 pmDSM-MIA
8h 55m2 stops
Southwest Logo
10:45 am - 2:55 pmMIA-DSM
5h 10m1 stop
$204Southwest
Find Deal
Wed, Nov 5 - Sat, Nov 8
Multiple Airlines Logo
8:47 pm - 11:45 amDSM-MIA
13h 58m1 stop
Multiple Airlines Logo
3:04 pm - 7:57 pmMIA-DSM
5h 53m1 stop
$210Multiple Airlines
Find Deal
Thu, Oct 30 - Sun, Nov 2
Delta Logo
6:32 pm - 12:46 amDSM-MIA
5h 14m1 stop
Delta Logo
6:00 am - 10:42 amMIA-DSM
5h 42m1 stop
$217Delta
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Wed, Nov 12 - Wed, Nov 19
American Airlines Logo
11:30 am - 8:20 pmDSM-MIA
7h 50m1 stop
American Airlines Logo
8:55 pm - 11:38 pmMIA-DSM
3h 43mnonstop
$230American Airlines
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Thu, Nov 13 - Tue, Nov 18
Delta Logo
6:39 pm - 12:29 amDSM-MIA
4h 50m1 stop
Delta Logo
6:00 am - 10:05 amMIA-DSM
5h 05m1 stop
$233Delta
Find Deal
Sun, Nov 2 - Sat, Nov 8
American Airlines Logo
5:25 pm - 12:28 amDSM-MIA
6h 03m1 stop
American Airlines Logo
8:50 pm - 11:29 pmMIA-DSM
3h 39mnonstop
$240American Airlines
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Thu, Dec 4 - Tue, Dec 9
United Airlines Logo
7:50 am - 3:05 pmDSM-MIA
6h 15m1 stop
United Airlines Logo
9:05 am - 2:22 pmMIA-DSM
6h 17m1 stop
$257United Airlines
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Sat, Jan 24 - Sat, Jan 31
United Airlines Logo
11:30 am - 10:20 pmDSM-MIA
9h 50m2 stops
United Airlines Logo
9:00 am - 2:33 pmMIA-DSM
6h 33m1 stop
$262United Airlines
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Sat, Jan 24 - Sat, Jan 31
Allegiant Air Logo
5:58 pm - 2:56 pmDSM-EYW
19h 58m1 stop
Allegiant Air Logo
3:52 pm - 10:17 pmEYW-DSM
7h 25m1 stop
$285Allegiant Air
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Sat, Jan 10 - Fri, Jan 16

Southwest flights from Des Moines to Florida Keys

Our best Southwest deals on Des Moines to Florida Keys flight tickets
Southwest
Dec 8
DSM6:15 amDes Moines
5h 10m
1 stop
MIA12:25 pmMiami
Dec 17
MIA4:55 pmMiami
5h 40m
1 stop
DSM9:35 pmDes Moines
$179
Find similar
Southwest
Nov 5
DSM6:15 amDes Moines
8h 55m
2 stops
MIA4:10 pmMiami
Nov 8
MIA10:45 amMiami
5h 10m
1 stop
DSM2:55 pmDes Moines
$204
Find similar
Southwest
Nov 15
DSM6:25 amDes Moines
9h 05m
1 stop
MIA4:30 pmMiami
Nov 22
MIA7:10 amMiami
4h 45m
1 stop
DSM10:55 amDes Moines
$223
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Delta flights from Des Moines to Florida Keys

Our best Delta deals on Des Moines to Florida Keys flight tickets
Delta
Nov 12
DSM11:00 amDes Moines
6h 09m
1 stop
MIA6:09 pmMiami
Nov 19
MIA1:31 pmMiami
7h 17m
1 stop
DSM7:48 pmDes Moines
$217
Find similar
Delta
Nov 2
DSM6:39 pmDes Moines
4h 50m
1 stop
MIA12:29 amMiami
Nov 8
MIA6:00 amMiami
5h 05m
1 stop
DSM10:05 amDes Moines
$233
Find similar
Delta
Dec 5
DSM6:33 pmDes Moines
5h 13m
1 stop
MIA12:46 amMiami
Dec 13
MIA7:00 amMiami
8h 12m
1 stop
DSM2:12 pmDes Moines
$259
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 12/8

6:15 am-12:25 pm

1 stop5h 10m

Miami

Wed 12/17

4:55 pm-9:35 pm

1 stop5h 40m

$179

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 11/5

6:15 am-4:10 pm

2 stops8h 55m

Miami

Sat 11/8

10:45 am-2:55 pm

1 stop5h 10m

$204

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 10/30

8:47 pm-11:45 am

1 stop13h 58m

Miami

Sun 11/2

3:04 pm-7:57 pm

1 stop5h 53m

$210

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 11/12

6:32 pm-12:46 am

1 stop5h 14m

Miami

Wed 11/19

6:00 am-10:42 am

1 stop5h 42m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 11/13

11:30 am-8:20 pm

1 stop7h 50m

Miami

Tue 11/18

8:55 pm-11:38 pm

Nonstop3h 43m

$230

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 11/2

6:39 pm-12:29 am

1 stop4h 50m

Miami

Sat 11/8

6:00 am-10:05 am

1 stop5h 05m

$233

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 12/4

5:25 pm-12:28 am

1 stop6h 03m

Miami

Tue 12/9

8:50 pm-11:29 pm

Nonstop3h 39m

$240

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/24

7:50 am-3:05 pm

1 stop6h 15m

Miami

Sat 1/31

9:05 am-2:22 pm

1 stop6h 17m

$257

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/24

11:30 am-10:20 pm

2 stops9h 50m

Miami

Sat 1/31

9:00 am-2:33 pm

1 stop6h 33m

$262

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 1/10

5:58 pm-2:56 pm

1 stop19h 58m

Key West

Fri 1/16

3:52 pm-10:17 pm

1 stop7h 25m

$285

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of August is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $355.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $520. The most expensive day to fly to Florida Keys is Saturday, with ticket prices averaging around $779.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the evening. momondo users have found flights departing from Des Moines to Florida Keys in the evening for as low as $278. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the morning are often more expensive with an average ticket price of $616.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $426 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $344 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time

3h 17m

Direct flights

Every day

Airports in Florida Keys

1 airport
The fastest flight from Des Moines to Florida Keys takes 3h 17m
Direct flights go from Des Moines to Florida Keys every day.
There is 1 airport near Florida Keys: Miami (MIA)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

    Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

  • How old do you have to be to fly from Des Moines Airport to Florida Keys?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to Florida Keys?

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
693 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
7,977 reviews
Search Delta flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
8,979 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florida Keys trip

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