What airlines fly to Florida Keys?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Florida Keys from Des Moines according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 4 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Florida Keys?

Delta is the most popular carrier operating from Des Moines to Florida Keys

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

The number of operators available for flights from Des Moines Airport to Florida Keys is 6 as of April 2026.

How old do you have to be to fly from Des Moines Airport to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$92 Cheap Flights from Des Moines to Florida Keys in 2026

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Find the cheapest flights from Des Moines to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:41 pm - 8:27 am

DSM

MIA

14h 46m

1 stop

9:38 pm - 10:31 pm

MIA

DSM

25h 53m

1 stop

$208Multiple Airlines

Thu, May 28 - Sat, May 30

4:41 pm - 8:27 am

DSM

MIA

14h 46m

1 stop

10:57 am - 1:50 pm

MIA

DSM

27h 53m

1 stop

$224Multiple Airlines

Thu, May 28 - Thu, Jun 4

4:57 pm - 8:33 pm

DSM

MIA

26h 36m

1 stop

8:55 pm - 10:47 pm

MIA

DSM

26h 52m

1 stop

$225Multiple Airlines

Sun, Jul 19 - Sat, Jul 25

4:41 pm - 8:27 am

DSM

MIA

14h 46m

1 stop

8:10 am - 10:58 pm

MIA

DSM

15h 48m

2 stops

$228Multiple Airlines

Thu, May 28 - Thu, Jun 4

6:30 am - 11:01 am

DSM

MIA

3h 31mnonstop

8:51 pm - 11:36 pm

MIA

DSM

3h 45mnonstop

$237American Airlines

Sat, Aug 29 - Sat, Sep 5

5:50 am - 10:08 am

DSM

MIA

3h 18mnonstop

8:30 pm - 11:08 pm

MIA

DSM

3h 38mnonstop

$238American Airlines

Wed, May 27 - Thu, May 28

2:04 pm - 5:05 am

DSM

MIA

14h 01m

1 stop

6:30 am - 1:31 pm

MIA

DSM

8h 01m

1 stop

$252Frontier

Fri, May 1 - Fri, May 8

11:57 am - 7:49 pm

DSM

EYW

6h 52m

1 stop

7:30 am - 1:37 pm

EYW

DSM

7h 07m

1 stop

$289Delta

Sat, May 16 - Wed, May 20

4:22 pm - 3:22 pm

DSM

EYW

22h 00m

1 stop

5:10 pm - 10:07 am

EYW

DSM

17h 57m

2 stops

$317Allegiant Air

Sat, Jun 27 - Wed, Jul 1

11:57 am - 7:49 pm

DSM

EYW

6h 52m

1 stop

7:30 am - 1:37 pm

EYW

DSM

7h 07m

1 stop

$319Delta

Sat, May 16 - Wed, May 20

United Airlines flights from Des Moines to Florida Keys

Our best United Airlines deals on Des Moines to Florida Keys flight tickets

United Airlines

May 9

DSM5:30 amDes Moines

9h 16m

2 stops

MIA3:46 pmMiami

May 12

MIA4:52 pmMiami

6h 53m

1 stop

DSM10:45 pmDes Moines

$262

United Airlines

May 9

DSM5:30 amDes Moines

9h 16m

2 stops

MIA3:46 pmMiami

May 18

MIA4:20 pmMiami

8h 04m

1 stop

DSM11:24 pmDes Moines

$294

United Airlines

May 16

DSM8:15 amDes Moines

6h 31m

1 stop

MIA3:46 pmMiami

May 19

MIA10:50 amMiami

10h 26m

2 stops

DSM8:16 pmDes Moines

$304

Frontier flights from Des Moines to Florida Keys

Our best Frontier deals on Des Moines to Florida Keys flight tickets

Frontier

Apr 27

DSM2:04 pmDes Moines

14h 01m

1 stop

MIA5:05 amMiami

May 8

MIA6:30 amMiami

8h 01m

1 stop

DSM1:31 pmDes Moines

$250

Frontier

May 1

DSM2:04 pmDes Moines

14h 01m

1 stop

MIA5:05 amMiami

May 8

MIA6:30 amMiami

8h 01m

1 stop

DSM1:31 pmDes Moines

$252

Frontier

Jun 1

DSM2:16 pmDes Moines

14h 17m

1 stop

MIA5:33 amMiami

Jun 8

MIA6:30 amMiami

8h 01m

1 stop

DSM1:31 pmDes Moines

$272

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 5/28

4:41 pm-8:27 am

1 stop14h 46m

Miami

Sat 5/30

9:38 pm-10:31 pm

1 stop25h 53m

$208

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 5/28

4:41 pm-8:27 am

1 stop14h 46m

Miami

Thu 6/4

10:57 am-1:50 pm

1 stop27h 53m

$224

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 7/19

4:57 pm-8:33 pm

1 stop26h 36m

Miami

Sat 7/25

8:55 pm-10:47 pm

1 stop26h 52m

$225

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 5/28

4:41 pm-8:27 am

1 stop14h 46m

Miami

Thu 6/4

8:10 am-10:58 pm

2 stops15h 48m

$228

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 8/29

6:30 am-11:01 am

Nonstop3h 31m

Miami

Sat 9/5

8:51 pm-11:36 pm

Nonstop3h 45m

$237

Quickest round-trip

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 5/27

5:50 am-10:08 am

Nonstop3h 18m

Miami

Thu 5/28

8:30 pm-11:08 pm

Nonstop3h 38m

$238

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 5/1

2:04 pm-5:05 am

1 stop14h 01m

Miami

Fri 5/8

6:30 am-1:31 pm

1 stop8h 01m

$252

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/16

11:57 am-7:49 pm

1 stop6h 52m

Key West

Wed 5/20

7:30 am-1:37 pm

1 stop7h 07m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 6/27

4:22 pm-3:22 pm

1 stop22h 00m

Key West

Wed 7/1

5:10 pm-10:07 am

2 stops17h 57m

$317

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/16

11:57 am-7:49 pm

1 stop6h 52m

Key West

Wed 5/20

7:30 am-1:37 pm

1 stop7h 07m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Florida Keys?

The month of June is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $305.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $562. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $691.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $384 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $313 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Fastest flight time	3h 18m
Direct flights	Thu, Fri, Sat and Sun
Airports in Florida Keys	3 airports

The fastest flight from Des Moines to Florida Keys takes 3h 18m

Direct flights go from Des Moines to Florida Keys on Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.

There are 3 airports in Florida Keys. From Des Moines there are direct flights to Miami (MIA).

Search flight deals

Frequently asked questions about flying from Des Moines to Florida Keys

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?
Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Florida Keys?
The number of operators available for flights from Des Moines Airport to Florida Keys is 6 as of April 2026.
How old do you have to be to fly from Des Moines Airport to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Des Moines to Florida Keys?
momondo data reveals that the most frequently booked plane model on the route from Des Moines to Florida Keys is Airbus A320-100/200, representing 23.28% of all bookings. The subsequent popular models are Airbus A319 at 16.68%, Embraer 175 at 14.72%, and Embraer 175 (Enhanced Winglets) at 8.49%.

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.3 705 reviews	Search Allegiant Air flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.1 11,621 reviews	Search American Airlines flights
Delta	PriceFrom $268	Free Cancellation	Rating 7.9 8,422 reviews	Search Delta flights
United Airlines	PriceFrom $288	Free Cancellation	Rating 7.4 9,603 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.