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Cheap flights from Des Moines to Florida Keys from $89

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Florida Keys departing on 9/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Florida Keys

Cheap round-trip flights

American Airlines Logo
6:45 am - 11:15 amDSM-MIA
3h 30mnonstop
American Airlines Logo
7:51 pm - 10:30 pmMIA-DSM
3h 39mnonstop
$174American Airlines
Find Deal
Sat, Aug 23 - Sat, Aug 30
Southwest Logo
8:25 am - 2:05 pmDSM-MIA
4h 40m1 stop
Southwest Logo
2:50 pm - 10:20 pmMIA-DSM
8h 30m1 stop
$184Southwest
Find Deal
Tue, Sep 16 - Wed, Sep 17
Logo
8:47 pm - 11:45 amDSM-MIA
13h 58m1 stop
Logo
11:28 am - 8:13 pmMIA-DSM
9h 45m1 stop
$190
Find Deal
Sun, Nov 2 - Thu, Nov 6
Logo
8:30 am - 5:01 pmDSM-MIA
7h 31m1 stop
Logo
6:00 am - 4:59 pmMIA-DSM
11h 59m1 stop
$212
Find Deal
Mon, Oct 20 - Fri, Oct 24
Delta Logo
10:20 am - 6:51 pmDSM-MIA
7h 31m1 stop
Delta Logo
6:00 am - 10:40 amMIA-DSM
5h 40m1 stop
$217Delta
Find Deal
Sat, Sep 13 - Sat, Sep 20
Delta Logo
6:30 pm - 12:24 amDSM-MIA
4h 54m1 stop
Delta Logo
6:00 am - 10:38 amMIA-DSM
5h 38m1 stop
$238Delta
Find Deal
Tue, Aug 19 - Tue, Aug 26
Frontier Logo
6:20 pm - 6:30 amDSM-MIA
11h 10m1 stop
Frontier Logo
6:00 am - 2:23 pmMIA-DSM
9h 23m1 stop
$258Frontier
Find Deal
Fri, Aug 22 - Mon, Aug 25
Frontier Logo
8:44 pm - 6:19 amDSM-MIA
8h 35m1 stop
Frontier Logo
6:00 am - 7:59 pmMIA-DSM
14h 59m1 stop
$265Frontier
Find Deal
Fri, Oct 24 - Sun, Oct 26
United Airlines Logo
8:00 am - 4:54 pmDSM-MIA
7h 54m1 stop
United Airlines Logo
9:00 am - 2:11 pmMIA-DSM
6h 11m1 stop
$277United Airlines
Find Deal
Sat, Jan 10 - Thu, Jan 15
United Airlines Logo
8:00 am - 6:35 pmDSM-MIA
9h 35m2 stops
United Airlines Logo
9:00 am - 2:11 pmMIA-DSM
6h 11m1 stop
$282United Airlines
Find Deal
Sat, Jan 10 - Thu, Jan 15

Delta flights from Des Moines to Florida Keys

Our best Delta deals on Des Moines to Florida Keys flight tickets
Delta
Sep 13
DSM10:20 amDes Moines
7h 31m
1 stop
MIA6:51 pmMiami
Sep 20
MIA6:00 amMiami
5h 40m
1 stop
DSM10:40 amDes Moines
$217
Find similar
Delta
Aug 19
DSM6:30 pmDes Moines
4h 54m
1 stop
MIA12:24 amMiami
Aug 26
MIA6:00 amMiami
5h 38m
1 stop
DSM10:38 amDes Moines
$238
Find similar
Delta
Sep 15
DSM6:30 pmDes Moines
4h 53m
1 stop
MIA12:23 amMiami
Sep 22
MIA11:48 amMiami
8h 26m
1 stop
DSM7:14 pmDes Moines
$252
Find similar

United Airlines flights from Des Moines to Florida Keys

Our best United Airlines deals on Des Moines to Florida Keys flight tickets
United Airlines
Jan 10
DSM8:00 amDes Moines
7h 54m
1 stop
MIA4:54 pmMiami
Jan 15
MIA9:00 amMiami
6h 11m
1 stop
DSM2:11 pmDes Moines
$277
Find similar
United Airlines
Jan 10
DSM8:00 amDes Moines
9h 35m
2 stops
MIA6:35 pmMiami
Jan 15
MIA9:00 amMiami
6h 11m
1 stop
DSM2:11 pmDes Moines
$282
Find similar
United Airlines
Nov 1
DSM1:35 pmDes Moines
7h 24m
1 stop
MIA9:59 pmMiami
Nov 10
MIA7:00 amMiami
6h 14m
1 stop
DSM12:14 pmDes Moines
$287
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 1, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 8/23

6:45 am-11:15 am

Nonstop3h 30m

Miami

Sat 8/30

7:51 pm-10:30 pm

Nonstop3h 39m

$174

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 9/16

8:25 am-2:05 pm

1 stop4h 40m

Miami

Wed 9/17

2:50 pm-10:20 pm

1 stop8h 30m

$184

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 11/2

8:47 pm-11:45 am

1 stop13h 58m

Miami

Thu 11/6

11:28 am-8:13 pm

1 stop9h 45m

$190

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 10/20

8:30 am-5:01 pm

1 stop7h 31m

Miami

Fri 10/24

6:00 am-4:59 pm

1 stop11h 59m

$212

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 9/13

10:20 am-6:51 pm

1 stop7h 31m

Miami

Sat 9/20

6:00 am-10:40 am

1 stop5h 40m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 8/19

6:30 pm-12:24 am

1 stop4h 54m

Miami

Tue 8/26

6:00 am-10:38 am

1 stop5h 38m

$238

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 8/22

6:20 pm-6:30 am

1 stop11h 10m

Miami

Mon 8/25

6:00 am-2:23 pm

1 stop9h 23m

$258

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 10/24

8:44 pm-6:19 am

1 stop8h 35m

Miami

Sun 10/26

6:00 am-7:59 pm

1 stop14h 59m

$265

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/10

8:00 am-4:54 pm

1 stop7h 54m

Miami

Thu 1/15

9:00 am-2:11 pm

1 stop6h 11m

$277

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/10

8:00 am-6:35 pm

2 stops9h 35m

Miami

Thu 1/15

9:00 am-2:11 pm

1 stop6h 11m

$282

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of September is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $365.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $562. The most expensive day to fly to Florida Keys is Saturday, with ticket prices averaging around $720.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the evening. momondo users have found flights departing from Des Moines to Florida Keys in the evening for as low as $278. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the morning are often more expensive with an average ticket price of $619.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $336 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Best Price Found

$89

Fastest flight time

3h 30m

Direct flights

Every day

Airports in Florida Keys

2 airports
The best one-way flight to Florida Keys from Des Moines in the past 72 hours is $89. The best round-trip flight deal from Des Moines to Florida Keys found on momondo in the last 72 hours is $174.
The fastest flight from Des Moines to Florida Keys takes 3h 30m
Direct flights go from Des Moines to Florida Keys every day.
There are 2 airports near Florida Keys: Key West (EYW), Miami (MIA)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

    Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

  • How old do you have to be to fly from Des Moines Airport to Florida Keys?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to Florida Keys?

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $268Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $292Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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