What is the cheapest airline that flies from Des Moines to Florida Keys?

Allegiant Air is the most popular carrier operating from Des Moines to Florida Keys

How many flights depart from Des Moines to Florida Keys on average per week?

As of September 2026, 2 flights take off from Des Moines and land in Florida Keys each week. The most common flight departure day for this route is Sat, with 100% of weekly flights taking off on this day.

What airlines fly to Florida Keys?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Florida Keys from Des Moines according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 3 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?

Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Florida Keys?

The number of operators available for flights from Des Moines Airport to Florida Keys is 4 as of September 2026.

How old do you have to be to fly from Des Moines Airport to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$92 Cheap Flights from Des Moines to Florida Keys in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:43 am - 7:34 pmDSM Des Moines-EYW Key West

33h 51m2 stops Philadelphia Tampa

8:36 pm - 8:25 amEYW Key West-DSM Des Moines

12h 49m1 stop Orlando Sanford Intl

$291Multiple Airlines

Sun, Oct 18 - Thu, Oct 22

11:35 am - 8:02 pmDSM Des Moines-EYW Key West

7h 27m1 stop Atlanta Hartsfield-Jackson

6:06 pm - 10:38 pmEYW Key West-DSM Des Moines

5h 32m1 stop Atlanta Hartsfield-Jackson

$299Delta

Sat, Dec 5 - Wed, Dec 9

8:30 pm - 12:46 amDSM Des Moines-MIA Miami

27h 16m1 stop Denver Intl

5:50 am - 7:30 pmMIA Miami-DSM Des Moines

14h 40m1 stop Denver Intl

$308Frontier

Mon, Oct 5 - Mon, Oct 12

11:35 am - 8:02 pmDSM Des Moines-EYW Key West

7h 27m1 stop Atlanta Hartsfield-Jackson

6:06 pm - 10:38 pmEYW Key West-DSM Des Moines

5h 32m1 stop Atlanta Hartsfield-Jackson

$319Delta

Sat, Dec 5 - Wed, Dec 9

9:45 am - 4:55 pmDSM Des Moines-EYW Key West

6h 10m1 stop Dallas/Fort Worth

6:25 pm - 12:26 amEYW Key West-DSM Des Moines

7h 01m1 stop Chicago O'Hare Intl

$348American Airlines

Sat, Dec 5 - Wed, Dec 9

7:00 am - 1:35 pmDSM Des Moines-EYW Key West

5h 35m1 stop Charlotte Douglas

4:45 pm - 11:58 pmEYW Key West-DSM Des Moines

8h 13m1 stop Charlotte Douglas

$348American Airlines

Tue, Oct 20 - Sat, Oct 24

5:20 am - 11:35 amDSM Des Moines-MIA Miami

5h 15m1 stop Chicago Midway

6:50 am - 11:20 amMIA Miami-DSM Des Moines

5h 30m1 stop Chicago Midway

$417Southwest

Sat, Feb 6 - Sat, Feb 13

6:55 am - 4:50 pmDSM Des Moines-MIA Miami

8h 55m1 stop Denver Intl

6:50 am - 11:20 amMIA Miami-DSM Des Moines

5h 30m1 stop Chicago Midway

$417Southwest

Wed, Feb 17 - Sat, Feb 27

3:22 pm - 10:34 pmDSM Des Moines-MIA Miami

6h 12m1 stop Chicago O'Hare Intl

1:56 pm - 9:23 pmMIA Miami-DSM Des Moines

8h 27m2 stops Cleveland Hopkins Intl Chicago O'Hare Intl

$454United Airlines

Wed, Dec 16 - Wed, Dec 23

3:22 pm - 10:34 pmDSM Des Moines-MIA Miami

6h 12m1 stop Chicago O'Hare Intl

1:56 pm - 9:23 pmMIA Miami-DSM Des Moines

8h 27m2 stops Cleveland Hopkins Intl Chicago O'Hare Intl

$474United Airlines

Wed, Dec 16 - Wed, Dec 23

Cheap last minute flights

Enter your travel dates to find the best prices.

8:30 pm - 12:46 amDSM Des Moines-MIA Miami

27h 16m1 stop Denver Intl

5:50 am - 7:33 pmMIA Miami-DSM Des Moines

14h 43m1 stop Denver Intl

$345Frontier

Fri, Sep 11 - Mon, Sep 14

8:30 pm - 12:46 amDSM Des Moines-MIA Miami

27h 16m1 stop Denver Intl

5:50 am - 7:33 pmMIA Miami-DSM Des Moines

14h 43m1 stop Denver Intl

$350Frontier

Fri, Sep 11 - Mon, Sep 14

8:30 pm - 12:46 amDSM Des Moines-MIA Miami

27h 16m1 stop Denver Intl

5:50 am - 7:33 pmMIA Miami-DSM Des Moines

14h 43m1 stop Denver Intl

$360Frontier

Fri, Sep 11 - Mon, Sep 14

7:05 am - 2:19 pmDSM Des Moines-MIA Miami

6h 14m1 stop Chicago O'Hare Intl

4:43 pm - 11:12 pmMIA Miami-DSM Des Moines

7h 29m1 stop Dallas/Fort Worth

$478American Airlines

Wed, Sep 9 - Tue, Sep 15

11:31 am - 5:20 pmDSM Des Moines-MIA Miami

4h 49m1 stop Atlanta Hartsfield-Jackson

6:25 pm - 10:26 pmMIA Miami-DSM Des Moines

5h 01m1 stop Atlanta Hartsfield-Jackson

$478Delta

Wed, Sep 9 - Tue, Sep 15

7:05 am - 2:19 pmDSM Des Moines-MIA Miami

6h 14m1 stop Chicago O'Hare Intl

4:43 pm - 11:12 pmMIA Miami-DSM Des Moines

7h 29m1 stop Dallas/Fort Worth

$507American Airlines

Wed, Sep 9 - Tue, Sep 15

11:32 am - 11:44 pmDSM Des Moines-MIA Miami

11h 12m2 stops Chicago O'Hare Intl Newark

12:17 pm - 5:28 pmMIA Miami-DSM Des Moines

6h 11m1 stop Chicago O'Hare Intl

$512United Airlines

Sat, Sep 12 - Tue, Sep 15

7:00 am - 5:45 pmDSM Des Moines-MIA Miami

9h 45m1 stop Denver Intl

3:35 pm - 10:55 pmMIA Miami-DSM Des Moines

8h 20m1 stop Chicago Midway

$516Southwest

Fri, Sep 11 - Sun, Sep 20

5:40 am - 12:10 pmDSM Des Moines-MIA Miami

5h 30m1 stop Chicago Midway

7:15 am - 11:25 amMIA Miami-DSM Des Moines

5h 10m1 stop Chicago Midway

$516Southwest

Mon, Sep 7 - Fri, Sep 11

3:02 pm - 10:34 pmDSM Des Moines-MIA Miami

6h 32m1 stop Houston George Bush Intcntl

7:00 am - 5:28 pmMIA Miami-DSM Des Moines

11h 28m2 stops Newark Chicago O'Hare Intl

$573United Airlines

Wed, Sep 9 - Tue, Sep 15

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Frontier flights from Des Moines to Florida Keys

Our best Frontier deals on Des Moines to Florida Keys flight tickets

Frontier

Oct 5

DSM8:30 pmDes Moines

27h 16m

1 stop

MIA12:46 amMiami

Oct 12

MIA5:50 amMiami

14h 40m

1 stop

DSM7:30 pmDes Moines

$308

Frontier

Sep 27

DSM11:29 amDes Moines

12h 17m

1 stop

MIA12:46 amMiami

Oct 3

MIA5:55 amMiami

29h 49m

1 stop

DSM10:44 amDes Moines

$312

Frontier

Oct 2

DSM8:30 pmDes Moines

27h 16m

1 stop

MIA12:46 amMiami

Oct 12

MIA5:50 amMiami

14h 40m

1 stop

DSM7:30 pmDes Moines

$316

United Airlines flights from Des Moines to Florida Keys

Our best United Airlines deals on Des Moines to Florida Keys flight tickets

United Airlines

Dec 16

DSM3:22 pmDes Moines

6h 12m

1 stop

MIA10:34 pmMiami

Dec 23

MIA1:56 pmMiami

8h 27m

2 stops

DSM9:23 pmDes Moines

$454

United Airlines

Sep 12

DSM11:32 amDes Moines

11h 12m

2 stops

MIA11:44 pmMiami

Sep 15

MIA12:17 pmMiami

6h 11m

1 stop

DSM5:28 pmDes Moines

$512

United Airlines

Sep 9

DSM3:02 pmDes Moines

6h 32m

1 stop

MIA10:34 pmMiami

Sep 15

MIA7:00 amMiami

11h 28m

2 stops

DSM5:28 pmDes Moines

$573

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sun 10/18

8:43 am-7:34 pm

2 stops33h 51m

Key West

Thu 10/22

8:36 pm-8:25 am

1 stop12h 49m

$291

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

11:35 am-8:02 pm

1 stop7h 27m

Key West

Wed 12/9

6:06 pm-10:38 pm

1 stop5h 32m

$299

Des MoinesMiami

DSM Des Moines - MIA Miami

DSMMIA

Des Moines

Mon 10/5

8:30 pm-12:46 am

1 stop27h 16m

Miami

Mon 10/12

5:50 am-7:30 pm

1 stop14h 40m

$308

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

11:35 am-8:02 pm

1 stop7h 27m

Key West

Wed 12/9

6:06 pm-10:38 pm

1 stop5h 32m

$319

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Sat 12/5

9:45 am-4:55 pm

1 stop6h 10m

Key West

Wed 12/9

6:25 pm-12:26 am

1 stop7h 01m

$348

Des MoinesKey West

DSM Des Moines - EYW Key West

DSMEYW

Des Moines

Tue 10/20

7:00 am-1:35 pm

1 stop5h 35m

Key West

Sat 10/24

4:45 pm-11:58 pm

1 stop8h 13m

$348

Quickest round-trip

Des MoinesMiami

DSM Des Moines - MIA Miami

DSMMIA

Des Moines

Sat 2/6

5:20 am-11:35 am

1 stop5h 15m

Miami

Sat 2/13

6:50 am-11:20 am

1 stop5h 30m

$417

Des MoinesMiami

DSM Des Moines - MIA Miami

DSMMIA

Des Moines

Wed 2/17

6:55 am-4:50 pm

1 stop8h 55m

Miami

Sat 2/27

6:50 am-11:20 am

1 stop5h 30m

$417

Des MoinesMiami

DSM Des Moines - MIA Miami

DSMMIA

Des Moines

Wed 12/16

3:22 pm-10:34 pm

1 stop6h 12m

Miami

Wed 12/23

1:56 pm-9:23 pm

2 stops8h 27m

$454

Des MoinesMiami

DSM Des Moines - MIA Miami

DSMMIA

Des Moines

Wed 12/16

3:22 pm-10:34 pm

1 stop6h 12m

Miami

Wed 12/23

1:56 pm-9:23 pm

2 stops8h 27m

$474

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Florida Keys?

The month of September is another great option to travel to Florida Keys, with average flight prices from Des Moines averaging around $387.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Des Moines to Florida Keys is on a Thursday when prices can be found for as low as $628. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $719.

How far in advance should I book a flight from Des Moines to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $423 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Des Moines for as low as $321 on momondo.

Can stopping save me money on Des Moines to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Florida Keys.

Cheap Des Moines to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Florida Keys

Best Price Found	$92
Fastest flight time	3h 17m
Direct flights	Every day
Airports in Florida Keys	3 airports

The best one-way flight to Florida Keys from Des Moines in the past 72 hours is $92. The best round-trip flight deal from Des Moines to Florida Keys found on momondo in the last 72 hours is $291.

The fastest flight from Des Moines to Florida Keys takes 3h 17m

Direct flights go from Des Moines to Florida Keys every day.

There are 3 airports in Florida Keys. From Des Moines there are direct flights to Miami (MIA).

Search flight deals

Frequently asked questions about flying from Des Moines to Florida Keys

When did momondo last update prices for flights from Des Moines Airport to Florida Keys?
Prices for flights from Des Moines Airport to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Florida Keys?
The number of operators available for flights from Des Moines Airport to Florida Keys is 4 as of September 2026.
How old do you have to be to fly from Des Moines Airport to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Des Moines to Florida Keys?
momondo data reveals that the most frequently booked plane model on the route from Des Moines to Florida Keys is Airbus A320-100/200, representing 21.48% of all bookings. The subsequent popular models are Airbus A319 at 13.65%, Embraer 175 at 11.33%, and Embraer 175 (Enhanced Winglets) at 9.06%.

Best airlines flying from Des Moines to Florida Keys

Compare and see reviews for airlines that fly from Des Moines to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $268	Free Cancellation	Rating 7.8 8,557 reviews	Search Delta flights
United Airlines	PriceFrom $288	Free Cancellation	Rating 7.4 10,173 reviews	Search United Airlines flights
American Airlines	PriceFrom $289	Free Cancellation	Rating 7.1 12,039 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Florida Keys?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Florida Keys. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Florida Keys with flexible booking policies on momondo?

All flight searches from Des Moines to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Florida Keys right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florida Keys from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.