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Cheap flights from Columbia, Missouri to Knoxville from $338

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to Knoxville departing on 8/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Columbia, Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
3:05 pm - 8:48 pm
COU
-
TYS
4h 43m
1 stop
United Airlines Logo
6:30 am - 10:55 am
TYS
-
COU
5h 25m
1 stop
$338United Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
11:30 am - 9:30 pm
COU
-
TYS
9h 00m
2 stops
United Airlines Logo
6:30 am - 10:55 am
TYS
-
COU
5h 25m
1 stop
$344United Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
11:30 am - 9:30 pm
COU
-
TYS
9h 00m
2 stops
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
COU
11h 30m
2 stops
$349United Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
3:05 pm - 8:48 pm
COU
-
TYS
4h 43m
1 stop
United Airlines Logo
6:30 am - 10:55 am
TYS
-
COU
5h 25m
1 stop
$358United Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
3:05 pm - 8:48 pm
COU
-
TYS
4h 43m
1 stop
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
COU
11h 30m
2 stops
$364United Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
11:30 am - 9:30 pm
COU
-
TYS
9h 00m
2 stops
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
COU
11h 30m
2 stops
$369United Airlines
Sat, Aug 15 - Wed, Aug 19
American Airlines Logo
5:21 pm - 11:56 pm
COU
-
TYS
5h 35m
1 stop
American Airlines Logo
1:20 pm - 7:13 pm
TYS
-
COU
6h 53m
1 stop
$506American Airlines
Mon, Apr 13 - Wed, Apr 15
American Airlines Logo
10:16 am - 4:40 pm
COU
-
TYS
5h 24m
1 stop
American Airlines Logo
8:57 am - 3:58 pm
TYS
-
COU
8h 01m
2 stops
$512American Airlines
Mon, Apr 13 - Wed, Apr 15
American Airlines Logo
10:30 am - 6:23 pm
COU
-
TYS
6h 53m
1 stop
American Airlines Logo
6:07 pm - 10:46 pm
TYS
-
COU
5h 39m
1 stop
$513American Airlines
Fri, Jun 19 - Mon, Jun 22
United Airlines Logo
5:00 am - 3:09 pm
COU
-
TYS
9h 09m
2 stops
United Airlines Logo
9:00 am - 9:03 pm
TYS
-
COU
13h 03m
2 stops
$517United Airlines
Mon, Apr 13 - Wed, Apr 15

American Airlines flights from Columbia, Missouri to Knoxville

Our best American Airlines deals on Columbia, Missouri to Knoxville flight tickets
American Airlines
Apr 13
COU5:21 pmColumbia Regional
5h 35m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 15
TYS1:20 pmKnoxville McGhee Tyson
6h 53m
1 stop
COU7:13 pmColumbia Regional
$506
American Airlines
Apr 13
COU10:16 amColumbia Regional
5h 24m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
Apr 15
TYS8:57 amKnoxville McGhee Tyson
8h 01m
2 stops
COU3:58 pmColumbia Regional
$512
American Airlines
Jun 19
COU10:30 amColumbia Regional
6h 53m
1 stop
TYS6:23 pmKnoxville McGhee Tyson
Jun 22
TYS6:07 pmKnoxville McGhee Tyson
5h 39m
1 stop
COU10:46 pmColumbia Regional
$513

United Airlines flights from Columbia, Missouri to Knoxville

Our best United Airlines deals on Columbia, Missouri to Knoxville flight tickets
United Airlines
Aug 15
COU3:05 pmColumbia Regional
4h 43m
1 stop
TYS8:48 pmKnoxville McGhee Tyson
Aug 19
TYS6:30 amKnoxville McGhee Tyson
5h 25m
1 stop
COU10:55 amColumbia Regional
$338
United Airlines
Aug 15
COU11:30 amColumbia Regional
9h 00m
2 stops
TYS9:30 pmKnoxville McGhee Tyson
Aug 19
TYS6:30 amKnoxville McGhee Tyson
5h 25m
1 stop
COU10:55 amColumbia Regional
$344
United Airlines
Aug 15
COU11:30 amColumbia Regional
9h 00m
2 stops
TYS9:30 pmKnoxville McGhee Tyson
Aug 19
TYS7:15 amKnoxville McGhee Tyson
11h 30m
2 stops
COU5:45 pmColumbia Regional
$349

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 15, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

3:05 pm-8:48 pm

1 stop4h 43m

Knoxville McGhee Tyson

Wed 8/19

6:30 am-10:55 am

1 stop5h 25m

$338

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

11:30 am-9:30 pm

2 stops9h 00m

Knoxville McGhee Tyson

Wed 8/19

6:30 am-10:55 am

1 stop5h 25m

$344

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

11:30 am-9:30 pm

2 stops9h 00m

Knoxville McGhee Tyson

Wed 8/19

7:15 am-5:45 pm

2 stops11h 30m

$349

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

3:05 pm-8:48 pm

1 stop4h 43m

Knoxville McGhee Tyson

Wed 8/19

6:30 am-10:55 am

1 stop5h 25m

$358

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

3:05 pm-8:48 pm

1 stop4h 43m

Knoxville McGhee Tyson

Wed 8/19

7:15 am-5:45 pm

2 stops11h 30m

$364

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

11:30 am-9:30 pm

2 stops9h 00m

Knoxville McGhee Tyson

Wed 8/19

7:15 am-5:45 pm

2 stops11h 30m

$369

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 4/13

5:21 pm-11:56 pm

1 stop5h 35m

Knoxville McGhee Tyson

Wed 4/15

1:20 pm-7:13 pm

1 stop6h 53m

$506

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 4/13

10:16 am-4:40 pm

1 stop5h 24m

Knoxville McGhee Tyson

Wed 4/15

8:57 am-3:58 pm

2 stops8h 01m

$512

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 6/19

10:30 am-6:23 pm

1 stop6h 53m

Knoxville McGhee Tyson

Mon 6/22

6:07 pm-10:46 pm

1 stop5h 39m

$513

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 4/13

5:00 am-3:09 pm

2 stops9h 09m

Knoxville McGhee Tyson

Wed 4/15

9:00 am-9:03 pm

2 stops13h 03m

$517

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Fastest flight time

4h 43m

Direct flights

None
The fastest flight from Columbia, Missouri to Knoxville takes 4h 43m
There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.
Search flight deals

  • How far is Columbia Regional to Knoxville McGhee Tyson by plane?

    The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 43m by plane in normal conditions.

  • When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • How do I get Price Alerts for flights from Columbia, Missouri to Knoxville?

    Confirm your travel details to search for the latest offers for flights from Columbia, Missouri to Knoxville. While browsing offers there will be the option to toggle “Price Alerts”. You’ll then receive updates when prices for the flight route increase or decrease.

  • How can I save money on flights from Columbia, Missouri to Knoxville with momondo?

    With “Price Forecast”, learn how soon you should book your flight in advance. Down to the day of week and time of day, our information can inform you on the ideal time to book to save on your travel. Our “Price Calendar” shows you at a quick glance when to book your travel for lower rates. By setting “Price Alerts” you can monitor changes in price and target the ideal time to book. Search for your trip destination by budget amount via our “Explore” feature. Whether you’re looking for ideas for your next travel adventure or cost-cutting tips, our “Discover” content is a great place to start.

  • How does momondo find its flight prices?

    We aggregate our prices from over 700+ competitors from airlines to OTAs. We operate in over 30 markets worldwide to show you a wide range of travel options.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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