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Cheap flights from Columbia, Missouri to Knoxville from $191

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to Knoxville departing on 8/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Columbia, Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
11:44 am - 5:36 pm
COU
-
TYS
28h 52m
1 stop
Allegiant Air Logo
2:12 pm - 9:06 am
TYS
-
COU
19h 54m
1 stop
$191Allegiant Air
Wed, Aug 12 - Sun, Aug 16
Allegiant Air Logo
11:44 am - 3:06 pm
COU
-
TYS
26h 22m
1 stop
Allegiant Air Logo
9:08 pm - 10:39 am
TYS
-
COU
14h 31m
1 stop
$224Allegiant Air
Wed, Aug 12 - Fri, Aug 14
Allegiant Air Logo
10:34 am - 5:37 pm
COU
-
TYS
6h 03m
1 stop
Allegiant Air Logo
1:21 pm - 9:09 am
TYS
-
COU
20h 48m
1 stop
$233Allegiant Air
Mon, Aug 24 - Thu, Aug 27
Allegiant Air Logo
11:44 am - 6:25 pm
COU
-
TYS
5h 41m
1 stop
Allegiant Air Logo
4:20 pm - 10:54 am
TYS
-
COU
19h 34m
1 stop
$257Allegiant Air
Wed, Jul 8 - Tue, Jul 14
Allegiant Air Logo
11:29 am - 10:03 pm
COU
-
TYS
9h 34m
1 stop
Allegiant Air Logo
2:12 pm - 9:06 am
TYS
-
COU
19h 54m
1 stop
$271Allegiant Air
Sat, Aug 8 - Sun, Aug 16
United Airlines Logo
3:25 pm - 8:44 pm
COU
-
TYS
4h 19m
1 stop
United Airlines Logo
6:00 am - 10:13 am
TYS
-
COU
5h 13m
1 stop
$278United Airlines
Sat, Aug 1 - Thu, Aug 6
Allegiant Air Logo
11:29 am - 10:03 pm
COU
-
TYS
9h 34m
1 stop
Allegiant Air Logo
9:08 pm - 10:39 am
TYS
-
COU
14h 31m
1 stop
$303Allegiant Air
Sat, Aug 8 - Fri, Aug 14
American Airlines Logo
5:19 pm - 11:55 pm
COU
-
TYS
5h 36m
1 stop
American Airlines Logo
6:22 am - 9:57 am
TYS
-
COU
4h 35m
1 stop
$308American Airlines
Tue, Jun 30 - Sat, Jul 4
American Airlines Logo
5:19 pm - 11:55 pm
COU
-
TYS
5h 36m
1 stop
American Airlines Logo
1:00 pm - 6:01 pm
TYS
-
COU
6h 01m
1 stop
$313American Airlines
Wed, Jul 1 - Wed, Jul 8
Allegiant Air Logo
9:39 am - 9:56 pm
COU
-
TYS
11h 17m
1 stop
Allegiant Air Logo
2:08 pm - 9:16 am
TYS
-
COU
20h 08m
1 stop
$321Allegiant Air
Sat, Jul 11 - Sun, Jul 26

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Allegiant Air flights from Columbia, Missouri to Knoxville

Our best Allegiant Air deals on Columbia, Missouri to Knoxville flight tickets
Allegiant Air
Aug 12
COU11:44 amColumbia Regional
28h 52m
1 stop
TYS5:36 pmKnoxville McGhee Tyson
Aug 16
TYS2:12 pmKnoxville McGhee Tyson
19h 54m
1 stop
COU9:06 amColumbia Regional
$191
Allegiant Air
Aug 12
COU11:44 amColumbia Regional
26h 22m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Aug 14
TYS9:08 pmKnoxville McGhee Tyson
14h 31m
1 stop
COU10:39 amColumbia Regional
$224
Allegiant Air
Aug 24
COU10:34 amColumbia Regional
6h 03m
1 stop
TYS5:37 pmKnoxville McGhee Tyson
Aug 27
TYS1:21 pmKnoxville McGhee Tyson
20h 48m
1 stop
COU9:09 amColumbia Regional
$233

United Airlines flights from Columbia, Missouri to Knoxville

Our best United Airlines deals on Columbia, Missouri to Knoxville flight tickets
United Airlines
Aug 1
COU3:25 pmColumbia Regional
4h 19m
1 stop
TYS8:44 pmKnoxville McGhee Tyson
Aug 6
TYS6:00 amKnoxville McGhee Tyson
5h 13m
1 stop
COU10:13 amColumbia Regional
$278
United Airlines
Dec 12
COU5:00 amColumbia Regional
7h 18m
1 stop
TYS1:18 pmKnoxville McGhee Tyson
Dec 15
TYS7:00 amKnoxville McGhee Tyson
4h 48m
1 stop
COU10:48 amColumbia Regional
$348
United Airlines
Dec 12
COU5:00 amColumbia Regional
8h 42m
2 stops
TYS2:42 pmKnoxville McGhee Tyson
Dec 15
TYS7:00 amKnoxville McGhee Tyson
4h 48m
1 stop
COU10:48 amColumbia Regional
$354

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 17, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 8/12

11:44 am-5:36 pm

1 stop28h 52m

Knoxville McGhee Tyson

Sun 8/16

2:12 pm-9:06 am

1 stop19h 54m

$191

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 8/12

11:44 am-3:06 pm

1 stop26h 22m

Knoxville McGhee Tyson

Fri 8/14

9:08 pm-10:39 am

1 stop14h 31m

$224

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 8/24

10:34 am-5:37 pm

1 stop6h 03m

Knoxville McGhee Tyson

Thu 8/27

1:21 pm-9:09 am

1 stop20h 48m

$233

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 7/8

11:44 am-6:25 pm

1 stop5h 41m

Knoxville McGhee Tyson

Tue 7/14

4:20 pm-10:54 am

1 stop19h 34m

$257

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/8

11:29 am-10:03 pm

1 stop9h 34m

Knoxville McGhee Tyson

Sun 8/16

2:12 pm-9:06 am

1 stop19h 54m

$271
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/1

3:25 pm-8:44 pm

1 stop4h 19m

Knoxville McGhee Tyson

Thu 8/6

6:00 am-10:13 am

1 stop5h 13m

$278

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/8

11:29 am-10:03 pm

1 stop9h 34m

Knoxville McGhee Tyson

Fri 8/14

9:08 pm-10:39 am

1 stop14h 31m

$303

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 6/30

5:19 pm-11:55 pm

1 stop5h 36m

Knoxville McGhee Tyson

Sat 7/4

6:22 am-9:57 am

1 stop4h 35m

$308

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 7/1

5:19 pm-11:55 pm

1 stop5h 36m

Knoxville McGhee Tyson

Wed 7/8

1:00 pm-6:01 pm

1 stop6h 01m

$313

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 7/11

9:39 am-9:56 pm

1 stop11h 17m

Knoxville McGhee Tyson

Sun 7/26

2:08 pm-9:16 am

1 stop20h 08m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Columbia, Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbia Regional to Knoxville McGhee Tyson?

American Airlines, United Airlines, and Allegiant Air are the most popular carriers operating from Columbia Regional to Knoxville McGhee Tyson

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Columbia, Missouri to Knoxville takes 4h 31m
There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.
Search flight deals

Frequently asked questions about flying from Columbia, Missouri to Knoxville

  • How far is Columbia Regional to Knoxville McGhee Tyson by plane?

    The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 31m by plane in normal conditions.

  • When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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