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Cheap flights from Columbia, Missouri to Knoxville from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to Knoxville departing on 10/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Columbia, Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:34 am - 5:37 pm
COU
-
TYS
6h 03m
1 stop
Allegiant Air Logo
8:00 am - 9:09 am
TYS
-
COU
26h 09m
1 stop
$215Allegiant Air
Mon, Aug 24 - Thu, Aug 27
Allegiant Air Logo
5:31 pm - 12:02 pm
COU
-
TYS
17h 31m
1 stop
Allegiant Air Logo
7:30 am - 5:32 pm
TYS
-
COU
11h 02m
1 stop
$290Allegiant Air
Fri, Sep 25 - Mon, Sep 28
Allegiant Air Logo
11:44 am - 6:28 pm
COU
-
TYS
5h 44m
1 stop
Allegiant Air Logo
2:12 pm - 9:06 am
TYS
-
COU
19h 54m
1 stop
$315Allegiant Air
Wed, Aug 12 - Sun, Aug 16
American Airlines Logo
7:00 am - 12:56 pm
COU
-
TYS
4h 56m
1 stop
American Airlines Logo
6:03 am - 11:16 am
TYS
-
COU
6h 13m
1 stop
$318American Airlines
Thu, Aug 13 - Mon, Aug 17
United Airlines Logo
10:49 am - 4:58 pm
COU
-
TYS
5h 09m
1 stop
United Airlines Logo
1:00 pm - 10:55 pm
TYS
-
COU
10h 55m
2 stops
$324United Airlines
Sat, Aug 15 - Wed, Aug 19
United Airlines Logo
6:15 am - 2:37 pm
COU
-
TYS
7h 22m
2 stops
United Airlines Logo
1:00 pm - 10:55 pm
TYS
-
COU
10h 55m
2 stops
$329United Airlines
Sat, Aug 15 - Wed, Aug 19
American Airlines Logo
6:00 am - 12:46 pm
COU
-
TYS
5h 46m
1 stop
American Airlines Logo
11:40 am - 6:03 pm
TYS
-
COU
7h 23m
1 stop
$338American Airlines
Sat, Aug 15 - Wed, Aug 19
Multiple Airlines Logo
10:34 am - 5:37 pm
COU
-
TYS
6h 03m
1 stop
Multiple Airlines Logo
7:00 am - 9:09 am
TYS
-
COU
27h 09m
2 stops
$346Multiple Airlines
Mon, Aug 24 - Thu, Aug 27
United Airlines Logo
6:15 am - 1:18 pm
COU
-
TYS
6h 03m
1 stop
United Airlines Logo
6:00 am - 10:39 am
TYS
-
COU
5h 39m
1 stop
$358United Airlines
Sat, Sep 5 - Wed, Sep 9
United Airlines Logo
6:15 am - 1:18 pm
COU
-
TYS
6h 03m
1 stop
United Airlines Logo
6:00 pm - 10:55 pm
TYS
-
COU
5h 55m
1 stop
$358United Airlines
Sat, Sep 5 - Wed, Sep 9

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United Airlines flights from Columbia, Missouri to Knoxville

Our best United Airlines deals on Columbia, Missouri to Knoxville flight tickets
United Airlines
Aug 15
COU10:49 amColumbia Regional
5h 09m
1 stop
TYS4:58 pmKnoxville McGhee Tyson
Aug 19
TYS1:00 pmKnoxville McGhee Tyson
10h 55m
2 stops
COU10:55 pmColumbia Regional
$324
United Airlines
Aug 15
COU6:15 amColumbia Regional
7h 22m
2 stops
TYS2:37 pmKnoxville McGhee Tyson
Aug 19
TYS1:00 pmKnoxville McGhee Tyson
10h 55m
2 stops
COU10:55 pmColumbia Regional
$329
United Airlines
Sep 5
COU6:15 amColumbia Regional
6h 03m
1 stop
TYS1:18 pmKnoxville McGhee Tyson
Sep 9
TYS6:00 pmKnoxville McGhee Tyson
5h 55m
1 stop
COU10:55 pmColumbia Regional
$358

Allegiant Air flights from Columbia, Missouri to Knoxville

Our best Allegiant Air deals on Columbia, Missouri to Knoxville flight tickets
Allegiant Air
Aug 24
COU10:34 amColumbia Regional
6h 03m
1 stop
TYS5:37 pmKnoxville McGhee Tyson
Aug 27
TYS8:00 amKnoxville McGhee Tyson
26h 09m
1 stop
COU9:09 amColumbia Regional
$215
Allegiant Air
Sep 25
COU5:31 pmColumbia Regional
17h 31m
1 stop
TYS12:02 pmKnoxville McGhee Tyson
Sep 28
TYS7:30 amKnoxville McGhee Tyson
11h 02m
1 stop
COU5:32 pmColumbia Regional
$290
Allegiant Air
Aug 12
COU11:44 amColumbia Regional
5h 44m
1 stop
TYS6:28 pmKnoxville McGhee Tyson
Aug 16
TYS2:12 pmKnoxville McGhee Tyson
19h 54m
1 stop
COU9:06 amColumbia Regional
$315

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 2, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 8/24

10:34 am-5:37 pm

1 stop6h 03m

Knoxville McGhee Tyson

Thu 8/27

8:00 am-9:09 am

1 stop26h 09m

$215

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 9/25

5:31 pm-12:02 pm

1 stop17h 31m

Knoxville McGhee Tyson

Mon 9/28

7:30 am-5:32 pm

1 stop11h 02m

$290

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 8/12

11:44 am-6:28 pm

1 stop5h 44m

Knoxville McGhee Tyson

Sun 8/16

2:12 pm-9:06 am

1 stop19h 54m

$315
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 8/13

7:00 am-12:56 pm

1 stop4h 56m

Knoxville McGhee Tyson

Mon 8/17

6:03 am-11:16 am

1 stop6h 13m

$318

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

10:49 am-4:58 pm

1 stop5h 09m

Knoxville McGhee Tyson

Wed 8/19

1:00 pm-10:55 pm

2 stops10h 55m

$324

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

6:15 am-2:37 pm

2 stops7h 22m

Knoxville McGhee Tyson

Wed 8/19

1:00 pm-10:55 pm

2 stops10h 55m

$329

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

6:00 am-12:46 pm

1 stop5h 46m

Knoxville McGhee Tyson

Wed 8/19

11:40 am-6:03 pm

1 stop7h 23m

$338

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 8/24

10:34 am-5:37 pm

1 stop6h 03m

Knoxville McGhee Tyson

Thu 8/27

7:00 am-9:09 am

2 stops27h 09m

$346

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 9/5

6:15 am-1:18 pm

1 stop6h 03m

Knoxville McGhee Tyson

Wed 9/9

6:00 am-10:39 am

1 stop5h 39m

$358

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 9/5

6:15 am-1:18 pm

1 stop6h 03m

Knoxville McGhee Tyson

Wed 9/9

6:00 pm-10:55 pm

1 stop5h 55m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Columbia, Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbia Regional to Knoxville McGhee Tyson?

Allegiant Air, American Airlines, and United Airlines are the most popular carriers operating from Columbia Regional to Knoxville McGhee Tyson

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Fastest flight time

4h 19m

Direct flights

None
The fastest flight from Columbia, Missouri to Knoxville takes 4h 19m
There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.
Search flight deals

Frequently asked questions about flying from Columbia, Missouri to Knoxville

  • How far is Columbia Regional to Knoxville McGhee Tyson by plane?

    The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 19m by plane in normal conditions.

  • When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbia, Missouri to Knoxville?

Best airlines flying from Columbia, Missouri to Knoxville

Compare and see reviews for airlines that fly from Columbia, Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $383Free CancellationRating
7.1
11,845 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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