When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

There is 1 operator available for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport as of August 2025.

How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$473 Cheap Flights from Columbia to Knoxville in 2025

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Find the cheapest flights from Columbia, Missouri to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

6:33 pm - 12:21 amCOU-TYS

4h 48m1 stop

6:00 am - 11:45 amTYS-COU

6h 45m1 stop

$539American Airlines

Find Deal

Fri, Oct 3 - Sun, Oct 12

6:24 am - 5:43 pmCOU-TYS

10h 19m2 stops

6:00 am - 11:45 amTYS-COU

6h 45m1 stop

$545American Airlines

Find Deal

Fri, Oct 3 - Sun, Oct 12

6:24 am - 5:43 pmCOU-TYS

10h 19m2 stops

5:00 am - 11:45 amTYS-COU

7h 45m2 stops

$620American Airlines

Find Deal

Fri, Oct 3 - Sun, Oct 12

1:36 pm - 9:00 pmCOU-TYS

6h 24m1 stop

5:30 am - 12:00 pmTYS-COU

7h 30m1 stop

$621American Airlines

Find Deal

Wed, Sep 10 - Sun, Sep 14

1:36 pm - 12:21 amCOU-TYS

9h 45m2 stops

7:30 am - 12:00 pmTYS-COU

5h 30m1 stop

$627American Airlines

Find Deal

Wed, Sep 10 - Sun, Sep 14

1:36 pm - 12:21 amCOU-TYS

9h 45m2 stops

6:30 am - 1:06 pmTYS-COU

7h 36m2 stops

$632American Airlines

Find Deal

Wed, Sep 10 - Sun, Sep 14

American Airlines flights from Columbia, Missouri to Knoxville

Our best American Airlines deals on Columbia, Missouri to Knoxville flight tickets

American Airlines

Sep 5

COU6:33 pmColumbia Regional

4h 48m

1 stop

TYS12:21 amKnoxville McGhee Tyson

Sep 7

TYS5:30 amKnoxville McGhee Tyson

7h 30m

1 stop

COU12:00 pmColumbia Regional

$489

Find similar

American Airlines

Sep 5

COU12:28 pmColumbia Regional

9h 35m

2 stops

TYS11:03 pmKnoxville McGhee Tyson

Sep 7

TYS5:30 amKnoxville McGhee Tyson

7h 30m

1 stop

COU12:00 pmColumbia Regional

$495

Find similar

American Airlines

Oct 3

COU6:33 pmColumbia Regional

4h 48m

1 stop

TYS12:21 amKnoxville McGhee Tyson

Oct 12

TYS6:00 amKnoxville McGhee Tyson

6h 45m

1 stop

COU11:45 amColumbia Regional

$539

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 10/3

6:33 pm-12:21 am

1 stop4h 48m

Knoxville McGhee Tyson

Sun 10/12

6:00 am-11:45 am

1 stop6h 45m

$539

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 10/3

6:24 am-5:43 pm

2 stops10h 19m

Knoxville McGhee Tyson

Sun 10/12

6:00 am-11:45 am

1 stop6h 45m

$545

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 10/3

6:24 am-5:43 pm

2 stops10h 19m

Knoxville McGhee Tyson

Sun 10/12

5:00 am-11:45 am

2 stops7h 45m

$620

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 9/10

1:36 pm-9:00 pm

1 stop6h 24m

Knoxville McGhee Tyson

Sun 9/14

5:30 am-12:00 pm

1 stop7h 30m

$621

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 9/10

1:36 pm-12:21 am

2 stops9h 45m

Knoxville McGhee Tyson

Sun 9/14

7:30 am-12:00 pm

1 stop5h 30m

$627

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 9/10

1:36 pm-12:21 am

2 stops9h 45m

Knoxville McGhee Tyson

Sun 9/14

6:30 am-1:06 pm

2 stops7h 36m

$632

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Columbia, Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Columbia, Missouri to Knoxville when you can find flight prices for as low as $539. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $610.

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Direct flights	None

There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.

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How far is Columbia Regional to Knoxville McGhee Tyson by plane?
The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 48m by plane in normal conditions.
When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?
There is 1 operator available for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport as of August 2025.
How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Columbia, Missouri to Knoxville?
Based on momondo bookings for flights between Columbia, Missouri and Knoxville, the leading airline is American Airlines, making up 100% of the total bookings.

Best airlines flying from Columbia, Missouri to Knoxville

Compare and see reviews for airlines that fly from Columbia, Missouri to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $434	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Newport

Alcoa

Lenoir City

Oak Ridge

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.