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Cheap flights from Columbia, Missouri to Knoxville from $268

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Columbia, Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:28 pm - 11:47 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 19m1 stop Chicago O'Hare Intl
American Airlines Logo
5:01 pm - 10:44 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
6h 43m1 stop Charlotte Douglas
$308American Airlines
Wed, Nov 25 - Tue, Dec 1
Allegiant Air Logo
12:58 pm - 10:36 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
8h 38m1 stop Orlando Sanford Intl
Allegiant Air Logo
2:09 pm - 4:18 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
27h 09m1 stop Valparaiso Destin-Ft Walton Beach
$311Allegiant Air
Fri, Nov 13 - Sun, Nov 15
American Airlines Logo
5:11 pm - 11:32 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
5h 21m1 stop Dallas/Fort Worth
American Airlines Logo
4:28 pm - 10:15 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
6h 47m1 stop Chicago O'Hare Intl
$338American Airlines
Tue, Nov 10 - Sat, Nov 14
American Airlines Logo
6:26 pm - 11:47 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 21m1 stop Chicago O'Hare Intl
American Airlines Logo
11:33 am - 5:52 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
7h 19m1 stop Chicago O'Hare Intl
$338American Airlines
Fri, Nov 13 - Tue, Nov 17
United Airlines Logo
8:00 am - 7:36 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
10h 36m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
10:51 am - 2:18 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
4h 27m1 stop Chicago O'Hare Intl
$344United Airlines
Tue, Nov 10 - Sat, Nov 14
United Airlines Logo
8:00 am - 7:36 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
10h 36m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
5:45 am - 2:18 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
9h 33m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
$349United Airlines
Tue, Nov 10 - Sat, Nov 14
Multiple Airlines Logo
12:58 pm - 10:36 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
8h 38m1 stop Orlando Sanford Intl
Multiple Airlines Logo
7:30 am - 10:43 amTYS  Knoxville McGhee Tyson-COU Columbia Regional
28h 13m2 stops Washington, D.C. Dulles Intl Orlando
$349Multiple Airlines
Fri, Nov 13 - Sun, Nov 15
United Airlines Logo
11:36 am - 4:54 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 18m1 stop Chicago O'Hare Intl
United Airlines Logo
5:55 pm - 11:30 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
6h 35m1 stop Chicago O'Hare Intl
$398United Airlines
Sat, Feb 6 - Tue, Feb 9
United Airlines Logo
11:36 am - 4:54 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 18m1 stop Chicago O'Hare Intl
United Airlines Logo
12:20 pm - 11:30 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
12h 10m2 stops Newark Chicago O'Hare Intl
$404United Airlines
Sat, Feb 6 - Tue, Feb 9
American Airlines Logo
5:11 pm - 11:40 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
5h 29m1 stop Dallas/Fort Worth
American Airlines Logo
4:17 pm - 11:01 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
7h 44m1 stop Charlotte Douglas
$422American Airlines
Fri, Dec 11 - Mon, Dec 14

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American Airlines flights from Columbia, Missouri to Knoxville

Our best American Airlines deals on Columbia, Missouri to Knoxville flight tickets
American Airlines
Nov 25
COU6:28 pmColumbia Regional
4h 19m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
Dec 1
TYS5:01 pmKnoxville McGhee Tyson
6h 43m
1 stop
COU10:44 pmColumbia Regional
$308
American Airlines
Nov 10
COU5:11 pmColumbia Regional
5h 21m
1 stop
TYS11:32 pmKnoxville McGhee Tyson
Nov 14
TYS4:28 pmKnoxville McGhee Tyson
6h 47m
1 stop
COU10:15 pmColumbia Regional
$338
American Airlines
Dec 11
COU5:11 pmColumbia Regional
5h 29m
1 stop
TYS11:40 pmKnoxville McGhee Tyson
Dec 14
TYS4:17 pmKnoxville McGhee Tyson
7h 44m
1 stop
COU11:01 pmColumbia Regional
$422

United Airlines flights from Columbia, Missouri to Knoxville

Our best United Airlines deals on Columbia, Missouri to Knoxville flight tickets
United Airlines
Nov 10
COU8:00 amColumbia Regional
10h 36m
2 stops
TYS7:36 pmKnoxville McGhee Tyson
Nov 14
TYS10:51 amKnoxville McGhee Tyson
4h 27m
1 stop
COU2:18 pmColumbia Regional
$344
United Airlines
Nov 10
COU8:00 amColumbia Regional
10h 36m
2 stops
TYS7:36 pmKnoxville McGhee Tyson
Nov 14
TYS5:45 amKnoxville McGhee Tyson
9h 33m
2 stops
COU2:18 pmColumbia Regional
$349
United Airlines
Feb 6
COU11:36 amColumbia Regional
4h 18m
1 stop
TYS4:54 pmKnoxville McGhee Tyson
Feb 9
TYS5:55 pmKnoxville McGhee Tyson
6h 35m
1 stop
COU11:30 pmColumbia Regional
$398

momondo Fare Finder

 
Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Wed 11/25

6:28 pm-11:47 pm

1 stop4h 19m

Knoxville McGhee Tyson

Tue 12/1

5:01 pm-10:44 pm

1 stop6h 43m

$308

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Fri 11/13

12:58 pm-10:36 pm

1 stop8h 38m

Knoxville McGhee Tyson

Sun 11/15

2:09 pm-4:18 pm

1 stop27h 09m

$311

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Tue 11/10

5:11 pm-11:32 pm

1 stop5h 21m

Knoxville McGhee Tyson

Sat 11/14

4:28 pm-10:15 pm

1 stop6h 47m

$338

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Fri 11/13

6:26 pm-11:47 pm

1 stop4h 21m

Knoxville McGhee Tyson

Tue 11/17

11:33 am-5:52 pm

1 stop7h 19m

$338

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Tue 11/10

8:00 am-7:36 pm

2 stops10h 36m

Knoxville McGhee Tyson

Sat 11/14

10:51 am-2:18 pm

1 stop4h 27m

$344

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Tue 11/10

8:00 am-7:36 pm

2 stops10h 36m

Knoxville McGhee Tyson

Sat 11/14

5:45 am-2:18 pm

2 stops9h 33m

$349

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Fri 11/13

12:58 pm-10:36 pm

1 stop8h 38m

Knoxville McGhee Tyson

Sun 11/15

7:30 am-10:43 am

2 stops28h 13m

$349
Quickest round-trip

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Sat 2/6

11:36 am-4:54 pm

1 stop4h 18m

Knoxville McGhee Tyson

Tue 2/9

5:55 pm-11:30 pm

1 stop6h 35m

$398

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Sat 2/6

11:36 am-4:54 pm

1 stop4h 18m

Knoxville McGhee Tyson

Tue 2/9

12:20 pm-11:30 pm

2 stops12h 10m

$404

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Fri 12/11

5:11 pm-11:40 pm

1 stop5h 29m

Knoxville McGhee Tyson

Mon 12/14

4:17 pm-11:01 pm

1 stop7h 44m

$422

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Columbia, Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbia Regional to Knoxville McGhee Tyson?

American Airlines and Allegiant Air are the most popular carriers operating from Columbia Regional to Knoxville McGhee Tyson

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Best Price Found

$268

Fastest flight time

4h 18m

Direct flights

None
The best one-way flight to Knoxville from Columbia, Missouri in the past 72 hours is $268. The best round-trip flight deal from Columbia, Missouri to Knoxville found on momondo in the last 72 hours is $308.
The fastest flight from Columbia, Missouri to Knoxville takes 4h 18m
There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.
Search flight deals

Frequently asked questions about flying from Columbia, Missouri to Knoxville

  • How far is Columbia Regional to Knoxville McGhee Tyson by plane?

    The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbia, Missouri to Knoxville?

Best airlines flying from Columbia, Missouri to Knoxville

Compare and see reviews for airlines that fly from Columbia, Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $288Free CancellationRating
7.0
12,209 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Kodak
Oak Ridge
Newport
Lenoir City
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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