When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

There is 1 operator available for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport as of October 2025.

How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$427 Cheap Flights from Columbia to Knoxville in 2025/26

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Find the cheapest flights from Columbia, Missouri to Knoxville

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

6:01 am - 2:33 pmCOU-TYS

7h 32m1 stop

1:13 pm - 9:55 pmTYS-COU

9h 42m1 stop

$427American Airlines

Find Deal

Thu, Oct 30 - Mon, Nov 3

5:47 pm - 11:41 pmCOU-TYS

4h 54m1 stop

11:34 am - 2:38 pmTYS-COU

4h 04m1 stop

$464American Airlines

Find Deal

Sat, Apr 4 - Wed, Apr 8

12:04 pm - 12:04 amCOU-TYS

11h 00m2 stops

3:03 pm - 7:57 pmTYS-COU

5h 54m1 stop

$470American Airlines

Find Deal

Sat, Apr 4 - Wed, Apr 8

6:01 am - 3:19 pmCOU-TYS

8h 18m2 stops

12:50 pm - 7:57 pmTYS-COU

8h 07m2 stops

$475American Airlines

Find Deal

Sat, Apr 4 - Wed, Apr 8

6:01 am - 4:51 pmCOU-TYS

9h 50m2 stops

6:18 pm - 10:39 pmTYS-COU

5h 21m1 stop

$567American Airlines

Find Deal

Thu, Oct 30 - Mon, Nov 3

6:01 am - 4:51 pmCOU-TYS

9h 50m2 stops

3:17 pm - 9:55 pmTYS-COU

7h 38m2 stops

$695American Airlines

Find Deal

Thu, Oct 30 - Mon, Nov 3

1:49 pm - 9:03 pmCOU-TYS

6h 14m1 stop

5:06 am - 12:22 pmTYS-COU

8h 16m2 stops

$782American Airlines

Find Deal

Wed, Oct 29 - Sun, Nov 2

6:01 am - 4:51 pmCOU-TYS

9h 50m2 stops

5:00 am - 12:22 pmTYS-COU

8h 22m2 stops

$787American Airlines

Find Deal

Wed, Oct 29 - Sun, Nov 2

1:49 pm - 9:03 pmCOU-TYS

6h 14m1 stop

7:54 am - 11:11 amTYS-COU

4h 17m1 stop

$901American Airlines

Find Deal

Wed, Oct 29 - Sun, Nov 2

American Airlines flights from Columbia, Missouri to Knoxville

Our best American Airlines deals on Columbia, Missouri to Knoxville flight tickets

American Airlines

Oct 30

COU6:01 amColumbia Regional

7h 32m

1 stop

TYS2:33 pmKnoxville McGhee Tyson

Nov 3

TYS1:13 pmKnoxville McGhee Tyson

9h 42m

1 stop

COU9:55 pmColumbia Regional

$427

Find similar

American Airlines

Apr 4

COU5:47 pmColumbia Regional

4h 54m

1 stop

TYS11:41 pmKnoxville McGhee Tyson

Apr 8

TYS11:34 amKnoxville McGhee Tyson

4h 04m

1 stop

COU2:38 pmColumbia Regional

$464

Find similar

American Airlines

Apr 4

COU12:04 pmColumbia Regional

11h 00m

2 stops

TYS12:04 amKnoxville McGhee Tyson

Apr 8

TYS3:03 pmKnoxville McGhee Tyson

5h 54m

1 stop

COU7:57 pmColumbia Regional

$470

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 10/30

6:01 am-2:33 pm

1 stop7h 32m

Knoxville McGhee Tyson

Mon 11/3

1:13 pm-9:55 pm

1 stop9h 42m

$427

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 4/4

5:47 pm-11:41 pm

1 stop4h 54m

Knoxville McGhee Tyson

Wed 4/8

11:34 am-2:38 pm

1 stop4h 04m

$464

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 4/4

12:04 pm-12:04 am

2 stops11h 00m

Knoxville McGhee Tyson

Wed 4/8

3:03 pm-7:57 pm

1 stop5h 54m

$470

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 4/4

6:01 am-3:19 pm

2 stops8h 18m

Knoxville McGhee Tyson

Wed 4/8

12:50 pm-7:57 pm

2 stops8h 07m

$475

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 10/30

6:01 am-4:51 pm

2 stops9h 50m

Knoxville McGhee Tyson

Mon 11/3

6:18 pm-10:39 pm

1 stop5h 21m

$567

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 10/30

6:01 am-4:51 pm

2 stops9h 50m

Knoxville McGhee Tyson

Mon 11/3

3:17 pm-9:55 pm

2 stops7h 38m

$695

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 10/29

1:49 pm-9:03 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sun 11/2

5:06 am-12:22 pm

2 stops8h 16m

$782

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 10/29

6:01 am-4:51 pm

2 stops9h 50m

Knoxville McGhee Tyson

Sun 11/2

5:00 am-12:22 pm

2 stops8h 22m

$787

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 10/29

1:49 pm-9:03 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sun 11/2

7:54 am-11:11 am

1 stop4h 17m

$901

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Columbia, Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Columbia, Missouri to Knoxville when you can find flight prices for as low as $539. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $610.

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Direct flights	None

There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.

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How far is Columbia Regional to Knoxville McGhee Tyson by plane?
The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 54m by plane in normal conditions.
When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?
There is 1 operator available for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport as of October 2025.
How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Columbia, Missouri to Knoxville?
Based on momondo bookings for flights between Columbia, Missouri and Knoxville, the leading airline is American Airlines, making up 100% of the total bookings.

Best airlines flying from Columbia, Missouri to Knoxville

Compare and see reviews for airlines that fly from Columbia, Missouri to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $430	Free Cancellation	Rating 7.2 11,043 reviews		Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Alcoa

Oak Ridge

Lenoir City

Newport

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.