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Cheap flights from Columbia, Missouri to Knoxville from $308

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to Knoxville departing on 2/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Columbia, Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:09 am - 4:48 pm
COU
-
TYS
7h 39m
1 stop
United Airlines Logo
6:45 am - 10:42 am
TYS
-
COU
4h 57m
1 stop
$308United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
8:45 am - 11:44 pm
COU
-
TYS
13h 59m
2 stops
United Airlines Logo
6:45 am - 10:42 am
TYS
-
COU
4h 57m
1 stop
$314United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
8:45 am - 11:44 pm
COU
-
TYS
13h 59m
2 stops
United Airlines Logo
9:30 am - 5:19 pm
TYS
-
COU
8h 49m
2 stops
$319United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
11:17 am - 4:48 pm
COU
-
TYS
4h 31m
1 stop
United Airlines Logo
6:45 am - 10:42 am
TYS
-
COU
4h 57m
1 stop
$328United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
8:09 am - 7:50 pm
COU
-
TYS
10h 41m
2 stops
United Airlines Logo
11:07 am - 5:19 pm
TYS
-
COU
7h 12m
1 stop
$334United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
11:17 am - 11:44 pm
COU
-
TYS
11h 27m
2 stops
United Airlines Logo
9:30 am - 5:19 pm
TYS
-
COU
8h 49m
2 stops
$339United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
3:16 pm - 11:59 pm
COU
-
TYS
7h 43m
2 stops
United Airlines Logo
5:39 pm - 9:10 pm
TYS
-
COU
4h 31m
1 stop
$370United Airlines
Sat, Jul 4 - Sat, Jul 11
United Airlines Logo
3:16 pm - 11:59 pm
COU
-
TYS
7h 43m
2 stops
United Airlines Logo
5:50 am - 2:29 pm
TYS
-
COU
9h 39m
2 stops
$375United Airlines
Sat, Jul 4 - Sat, Jul 11
United Airlines Logo
3:16 pm - 10:35 pm
COU
-
TYS
6h 19m
1 stop
United Airlines Logo
5:39 pm - 9:10 pm
TYS
-
COU
4h 31m
1 stop
$389United Airlines
Sat, Jul 4 - Sat, Jul 11
United Airlines Logo
11:15 am - 4:52 pm
COU
-
TYS
4h 37m
1 stop
United Airlines Logo
6:45 am - 10:33 am
TYS
-
COU
4h 48m
1 stop
$492United Airlines
Thu, Feb 12 - Mon, Feb 16

United Airlines flights from Columbia, Missouri to Knoxville

Our best United Airlines deals on Columbia, Missouri to Knoxville flight tickets
United Airlines
Feb 3
COU8:09 amColumbia Regional
7h 39m
1 stop
TYS4:48 pmKnoxville McGhee Tyson
Feb 7
TYS6:45 amKnoxville McGhee Tyson
4h 57m
1 stop
COU10:42 amColumbia Regional
$308
United Airlines
Feb 3
COU3:10 pmColumbia Regional
4h 42m
1 stop
TYS8:52 pmKnoxville McGhee Tyson
Feb 7
TYS9:30 amKnoxville McGhee Tyson
8h 49m
2 stops
COU5:19 pmColumbia Regional
$314
United Airlines
Feb 3
COU8:09 amColumbia Regional
10h 18m
2 stops
TYS7:27 pmKnoxville McGhee Tyson
Feb 7
TYS9:30 amKnoxville McGhee Tyson
8h 49m
2 stops
COU5:19 pmColumbia Regional
$319

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 2/3

8:09 am-4:48 pm

1 stop7h 39m

Knoxville McGhee Tyson

Sat 2/7

6:45 am-10:42 am

1 stop4h 57m

$308

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 2/3

8:45 am-11:44 pm

2 stops13h 59m

Knoxville McGhee Tyson

Sat 2/7

6:45 am-10:42 am

1 stop4h 57m

$314

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 2/3

8:45 am-11:44 pm

2 stops13h 59m

Knoxville McGhee Tyson

Sat 2/7

9:30 am-5:19 pm

2 stops8h 49m

$319

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 2/3

11:17 am-4:48 pm

1 stop4h 31m

Knoxville McGhee Tyson

Sat 2/7

6:45 am-10:42 am

1 stop4h 57m

$328

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 2/3

8:09 am-7:50 pm

2 stops10h 41m

Knoxville McGhee Tyson

Sat 2/7

11:07 am-5:19 pm

1 stop7h 12m

$334

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 2/3

11:17 am-11:44 pm

2 stops11h 27m

Knoxville McGhee Tyson

Sat 2/7

9:30 am-5:19 pm

2 stops8h 49m

$339

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 7/4

3:16 pm-11:59 pm

2 stops7h 43m

Knoxville McGhee Tyson

Sat 7/11

5:39 pm-9:10 pm

1 stop4h 31m

$370

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 7/4

3:16 pm-11:59 pm

2 stops7h 43m

Knoxville McGhee Tyson

Sat 7/11

5:50 am-2:29 pm

2 stops9h 39m

$375

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 7/4

3:16 pm-10:35 pm

1 stop6h 19m

Knoxville McGhee Tyson

Sat 7/11

5:39 pm-9:10 pm

1 stop4h 31m

$389

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 2/12

11:15 am-4:52 pm

1 stop4h 37m

Knoxville McGhee Tyson

Mon 2/16

6:45 am-10:33 am

1 stop4h 48m

$492

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Columbia, Missouri to Knoxville takes 4h 31m
There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.
Search flight deals

  • How far is Columbia Regional to Knoxville McGhee Tyson by plane?

    The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 31m by plane in normal conditions.

  • When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbia, Missouri to Knoxville?

Best airlines flying from Columbia, Missouri to Knoxville

Compare and see reviews for airlines that fly from Columbia, Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $430Free CancellationRating
7.2
11,174 reviews
Search American Airlines flights

  • How do I get Price Alerts for flights from Columbia, Missouri to Knoxville?

    Confirm your travel details to search for the latest offers for flights from Columbia, Missouri to Knoxville. While browsing offers there will be the option to toggle “Price Alerts”. You’ll then receive updates when prices for the flight route increase or decrease.

  • How can I save money on flights from Columbia, Missouri to Knoxville with momondo?

    With “Price Forecast”, learn how soon you should book your flight in advance. Down to the day of week and time of day, our information can inform you on the ideal time to book to save on your travel. Our “Price Calendar” shows you at a quick glance when to book your travel for lower rates. By setting “Price Alerts” you can monitor changes in price and target the ideal time to book. Search for your trip destination by budget amount via our “Explore” feature. Whether you’re looking for ideas for your next travel adventure or cost-cutting tips, our “Discover” content is a great place to start.

  • How does momondo find its flight prices?

    We aggregate our prices from over 700+ competitors from airlines to OTAs. We operate in over 30 markets worldwide to show you a wide range of travel options.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Murphy
Alcoa
Crossville
Maryville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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