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Cheap flights from Columbia, Missouri to Knoxville from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to Knoxville departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Find the cheapest flights from Columbia, Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:30 am - 4:59 pm
COU
-
TYS
4h 29m
1 stop
United Airlines Logo
6:30 am - 10:55 am
TYS
-
COU
5h 25m
1 stop
$348United Airlines
Sat, Aug 29 - Tue, Sep 1
United Airlines Logo
11:30 am - 4:59 pm
COU
-
TYS
4h 29m
1 stop
United Airlines Logo
12:05 pm - 9:49 pm
TYS
-
COU
10h 44m
2 stops
$354United Airlines
Sat, Aug 29 - Tue, Sep 1
United Airlines Logo
11:30 am - 9:30 pm
COU
-
TYS
9h 00m
2 stops
United Airlines Logo
5:45 am - 2:30 pm
TYS
-
COU
9h 45m
2 stops
$359United Airlines
Sat, Aug 29 - Tue, Sep 1
American Airlines Logo
6:47 pm - 11:53 pm
COU
-
TYS
4h 06m
1 stop
American Airlines Logo
5:37 am - 11:14 am
TYS
-
COU
6h 37m
1 stop
$441American Airlines
Fri, Jun 12 - Sun, Jun 14
American Airlines Logo
6:47 pm - 11:53 pm
COU
-
TYS
4h 06m
1 stop
American Airlines Logo
6:43 pm - 10:06 am
TYS
-
COU
16h 23m
1 stop
$485American Airlines
Thu, Jun 4 - Sun, Jun 7
American Airlines Logo
4:28 pm - 10:57 am
COU
-
TYS
17h 29m
1 stop
American Airlines Logo
6:54 pm - 10:53 pm
TYS
-
COU
4h 59m
1 stop
$491American Airlines
Fri, May 15 - Tue, May 19
American Airlines Logo
6:47 pm - 11:53 pm
COU
-
TYS
4h 06m
1 stop
American Airlines Logo
6:07 pm - 10:46 pm
TYS
-
COU
5h 39m
1 stop
$506American Airlines
Mon, Jun 8 - Fri, Jun 12
United Airlines Logo
3:10 pm - 8:45 pm
COU
-
TYS
4h 35m
1 stop
United Airlines Logo
7:00 am - 10:57 am
TYS
-
COU
4h 57m
1 stop
$564United Airlines
Wed, May 13 - Sun, May 17
American Airlines Logo
4:28 pm - 10:57 am
COU
-
TYS
17h 29m
1 stop
American Airlines Logo
7:00 am - 3:58 pm
TYS
-
COU
9h 58m
2 stops
$573American Airlines
Fri, May 15 - Tue, May 19
American Airlines Logo
6:00 am - 3:26 pm
COU
-
TYS
8h 26m
2 stops
American Airlines Logo
6:00 am - 11:35 am
TYS
-
COU
6h 35m
1 stop
$583American Airlines
Wed, May 13 - Sun, May 17

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American Airlines flights from Columbia, Missouri to Knoxville

Our best American Airlines deals on Columbia, Missouri to Knoxville flight tickets
American Airlines
Jun 12
COU6:47 pmColumbia Regional
4h 06m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
Jun 14
TYS5:37 amKnoxville McGhee Tyson
6h 37m
1 stop
COU11:14 amColumbia Regional
$441
American Airlines
Jun 4
COU6:47 pmColumbia Regional
4h 06m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
Jun 7
TYS6:43 pmKnoxville McGhee Tyson
16h 23m
1 stop
COU10:06 amColumbia Regional
$485
American Airlines
May 15
COU4:28 pmColumbia Regional
17h 29m
1 stop
TYS10:57 amKnoxville McGhee Tyson
May 19
TYS6:54 pmKnoxville McGhee Tyson
4h 59m
1 stop
COU10:53 pmColumbia Regional
$491

United Airlines flights from Columbia, Missouri to Knoxville

Our best United Airlines deals on Columbia, Missouri to Knoxville flight tickets
United Airlines
Aug 29
COU11:30 amColumbia Regional
4h 29m
1 stop
TYS4:59 pmKnoxville McGhee Tyson
Sep 1
TYS6:30 amKnoxville McGhee Tyson
5h 25m
1 stop
COU10:55 amColumbia Regional
$348
United Airlines
Aug 29
COU11:30 amColumbia Regional
4h 29m
1 stop
TYS4:59 pmKnoxville McGhee Tyson
Sep 1
TYS12:05 pmKnoxville McGhee Tyson
10h 44m
2 stops
COU9:49 pmColumbia Regional
$354
United Airlines
Aug 29
COU11:30 amColumbia Regional
9h 00m
2 stops
TYS9:30 pmKnoxville McGhee Tyson
Sep 1
TYS5:45 amKnoxville McGhee Tyson
9h 45m
2 stops
COU2:30 pmColumbia Regional
$359

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 3, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/29

11:30 am-4:59 pm

1 stop4h 29m

Knoxville McGhee Tyson

Tue 9/1

6:30 am-10:55 am

1 stop5h 25m

$348

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/29

11:30 am-4:59 pm

1 stop4h 29m

Knoxville McGhee Tyson

Tue 9/1

12:05 pm-9:49 pm

2 stops10h 44m

$354

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/29

11:30 am-9:30 pm

2 stops9h 00m

Knoxville McGhee Tyson

Tue 9/1

5:45 am-2:30 pm

2 stops9h 45m

$359

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 6/12

6:47 pm-11:53 pm

1 stop4h 06m

Knoxville McGhee Tyson

Sun 6/14

5:37 am-11:14 am

1 stop6h 37m

$441

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 6/4

6:47 pm-11:53 pm

1 stop4h 06m

Knoxville McGhee Tyson

Sun 6/7

6:43 pm-10:06 am

1 stop16h 23m

$485

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 5/15

4:28 pm-10:57 am

1 stop17h 29m

Knoxville McGhee Tyson

Tue 5/19

6:54 pm-10:53 pm

1 stop4h 59m

$491

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 6/8

6:47 pm-11:53 pm

1 stop4h 06m

Knoxville McGhee Tyson

Fri 6/12

6:07 pm-10:46 pm

1 stop5h 39m

$506
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 5/13

3:10 pm-8:45 pm

1 stop4h 35m

Knoxville McGhee Tyson

Sun 5/17

7:00 am-10:57 am

1 stop4h 57m

$564

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 5/15

4:28 pm-10:57 am

1 stop17h 29m

Knoxville McGhee Tyson

Tue 5/19

7:00 am-3:58 pm

2 stops9h 58m

$573

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 5/13

6:00 am-3:26 pm

2 stops8h 26m

Knoxville McGhee Tyson

Sun 5/17

6:00 am-11:35 am

1 stop6h 35m

$583

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Columbia, Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbia Regional to Knoxville McGhee Tyson?

Allegiant Air is the most popular carrier operating from Columbia Regional to Knoxville McGhee Tyson

When to book flights from Columbia, Missouri to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbia, Missouri to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbia, Missouri to Knoxville (COU to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to Knoxville

Fastest flight time

4h 35m

Direct flights

None
The fastest flight from Columbia, Missouri to Knoxville takes 4h 35m
There are no direct flights from Columbia, Missouri to Knoxville. There are no popular flight routes from Columbia, Missouri to Knoxville.
Search flight deals

Frequently asked questions about flying from Columbia, Missouri to Knoxville

  • How far is Columbia Regional to Knoxville McGhee Tyson by plane?

    The distance between Columbia Regional and Knoxville McGhee Tyson is about 505.0 mi. Typically, this will take 4h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbia Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How old do you have to be to fly from Columbia Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Columbia.

Can I find flights from Columbia to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Columbia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Columbia to Knoxville?

momondo helps you find the best flight between Columbia and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Columbia to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbia to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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