What is the cheapest airline that flies from Charleston to Knoxville McGhee Tyson?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Charleston to Knoxville McGhee Tyson

When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

The number of operators available for flights from Charleston Airport to Knoxville McGhee Tyson Airport is 2 as of August 2025.

How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$168 Cheap Flights from Charleston to Knoxville in 2025

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Find the cheapest flights from Charleston to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

6:20 am - 9:44 amCHS-TYS

3h 24m1 stop

8:35 am - 11:48 amTYS-CHS

3h 13m1 stop

$287Delta

Find Deal

Tue, Sep 16 - Tue, Sep 23

5:35 pm - 11:44 pmCHS-TYS

6h 09m1 stop

3:48 pm - 6:56 pmTYS-CHS

3h 08m1 stop

$297Delta

Find Deal

Sat, Oct 4 - Tue, Oct 7

2:59 pm - 8:50 pmCHS-TYS

5h 51m1 stop

8:31 pm - 12:05 amTYS-CHS

3h 34m1 stop

$307American Airlines

Find Deal

Fri, Sep 26 - Sun, Sep 28

5:15 am - 10:42 amCHS-TYS

5h 27m1 stop

6:14 pm - 9:24 pmTYS-CHS

3h 10m1 stop

$317Delta

Find Deal

Fri, Aug 29 - Fri, Sep 5

10:10 am - 1:29 pmCHS-TYS

27h 19m2 stops

5:55 pm - 9:05 amTYS-CHS

15h 10m1 stop

$321

Find Deal

Fri, Sep 26 - Sun, Sep 28

6:06 pm - 10:15 pmCHS-TYS

4h 09m1 stop

12:42 pm - 3:37 pmTYS-CHS

2h 55m1 stop

$327American Airlines

Find Deal

Thu, Aug 28 - Sun, Aug 31

5:36 pm - 11:03 pmCHS-TYS

5h 27m1 stop

8:31 pm - 12:05 amTYS-CHS

3h 34m1 stop

$343American Airlines

Find Deal

Fri, Sep 12 - Sun, Sep 14

10:10 am - 1:29 pmCHS-TYS

27h 19m3 stops

5:55 pm - 9:05 amTYS-CHS

15h 10m1 stop

$362

Find Deal

Fri, Sep 26 - Sun, Sep 28

4:34 pm - 10:13 amCHS-TYS

17h 39m1 stop

7:00 am - 10:07 pmTYS-CHS

15h 07m2 stops

$467United Airlines

Find Deal

Wed, Sep 3 - Wed, Sep 10

4:34 pm - 5:00 pmCHS-TYS

24h 26m1 stop

7:25 pm - 7:08 pmTYS-CHS

23h 43m2 stops

$469United Airlines

Find Deal

Fri, Aug 29 - Fri, Sep 5

Delta flights from Charleston to Knoxville

Our best Delta deals on Charleston to Knoxville flight tickets

Delta

Sep 16

CHS6:20 amCharleston

3h 24m

1 stop

TYS9:44 amKnoxville McGhee Tyson

Sep 23

TYS8:35 amKnoxville McGhee Tyson

3h 13m

1 stop

CHS11:48 amCharleston

$287

Find similar

Delta

Oct 4

CHS5:35 pmCharleston

6h 09m

1 stop

TYS11:44 pmKnoxville McGhee Tyson

Oct 7

TYS3:48 pmKnoxville McGhee Tyson

3h 08m

1 stop

CHS6:56 pmCharleston

$297

Find similar

Delta

Aug 29

CHS5:15 amCharleston

5h 27m

1 stop

TYS10:42 amKnoxville McGhee Tyson

Sep 5

TYS6:14 pmKnoxville McGhee Tyson

3h 10m

1 stop

CHS9:24 pmCharleston

$317

Find similar

American Airlines flights from Charleston to Knoxville

Our best American Airlines deals on Charleston to Knoxville flight tickets

American Airlines

Sep 26

CHS2:59 pmCharleston

5h 51m

1 stop

TYS8:50 pmKnoxville McGhee Tyson

Sep 28

TYS8:31 pmKnoxville McGhee Tyson

3h 34m

1 stop

CHS12:05 amCharleston

$307

Find similar

American Airlines

Aug 28

CHS6:06 pmCharleston

4h 09m

1 stop

TYS10:15 pmKnoxville McGhee Tyson

Aug 31

TYS12:42 pmKnoxville McGhee Tyson

2h 55m

1 stop

CHS3:37 pmCharleston

$327

Find similar

American Airlines

Sep 12

CHS5:36 pmCharleston

5h 27m

1 stop

TYS11:03 pmKnoxville McGhee Tyson

Sep 14

TYS8:31 pmKnoxville McGhee Tyson

3h 34m

1 stop

CHS12:05 amCharleston

$343

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 9/16

6:20 am-9:44 am

1 stop3h 24m

Knoxville McGhee Tyson

Tue 9/23

8:35 am-11:48 am

1 stop3h 13m

$287

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 10/4

5:35 pm-11:44 pm

1 stop6h 09m

Knoxville McGhee Tyson

Tue 10/7

3:48 pm-6:56 pm

1 stop3h 08m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/26

2:59 pm-8:50 pm

1 stop5h 51m

Knoxville McGhee Tyson

Sun 9/28

8:31 pm-12:05 am

1 stop3h 34m

$307

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 8/29

5:15 am-10:42 am

1 stop5h 27m

Knoxville McGhee Tyson

Fri 9/5

6:14 pm-9:24 pm

1 stop3h 10m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/26

10:10 am-1:29 pm

2 stops27h 19m

Knoxville McGhee Tyson

Sun 9/28

5:55 pm-9:05 am

1 stop15h 10m

$321

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 8/28

6:06 pm-10:15 pm

1 stop4h 09m

Knoxville McGhee Tyson

Sun 8/31

12:42 pm-3:37 pm

1 stop2h 55m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/12

5:36 pm-11:03 pm

1 stop5h 27m

Knoxville McGhee Tyson

Sun 9/14

8:31 pm-12:05 am

1 stop3h 34m

$343

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/26

10:10 am-1:29 pm

3 stops27h 19m

Knoxville McGhee Tyson

Sun 9/28

5:55 pm-9:05 am

1 stop15h 10m

$362

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 9/3

4:34 pm-10:13 am

1 stop17h 39m

Knoxville McGhee Tyson

Wed 9/10

7:00 am-10:07 pm

2 stops15h 07m

$467

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 8/29

4:34 pm-5:00 pm

1 stop24h 26m

Knoxville McGhee Tyson

Fri 9/5

7:25 pm-7:08 pm

2 stops23h 43m

$469

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Charleston, with most prices found around $356. If you aren’t able to travel during the month of June, then book flights to Knoxville from Charleston during May instead. Flights to Knoxville in May, while not as cheap as those in June, still average around $409.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Charleston to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $464. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Knoxville for around $780.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Charleston to Knoxville when you can find flight prices for as low as $525. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $696.

When to book flights from Charleston to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Best Price Found	$168
Fastest flight time	3h 24m
Direct flights	None
Airports in Knoxville	1 airport

The best one-way flight to Knoxville from Charleston in the past 72 hours is $168. The best round-trip flight deal from Charleston to Knoxville found on momondo in the last 72 hours is $287.

The fastest flight from Charleston to Knoxville takes 3h 24m

There are no direct flights from Charleston to Knoxville. Popular non-direct route for this connection is Charleston Airport - Knoxville McGhee Tyson Airport.

There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)

Search flight deals

How far is Charleston to Knoxville McGhee Tyson by plane?
A flight from Charleston to Knoxville McGhee Tyson will travel around 316.2 mi. Flights usually cover this in 3h 24m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?
The number of operators available for flights from Charleston Airport to Knoxville McGhee Tyson Airport is 2 as of August 2025.
How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Charleston to Knoxville?
momondo data reveals that the most frequently booked airline on the route from Charleston to Knoxville is American Airlines, representing 61% of all bookings. The subsequent popular airline is Delta at 39%.

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $326	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights
Delta	PriceFrom $356	Free Cancellation	Rating 8.0 7,985 reviews		Search Delta flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Newport

Alcoa

Lenoir City

Oak Ridge

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

It is quick and easy to find Charleston to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Charleston to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Charleston to Knoxville?

Once you have performed a search for Charleston to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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Cheap flights from Charleston to Knoxville from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Knoxville departing on 8/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

What is the cheapest day to depart on your flight to Knoxville?

What is the cheapest time of day to depart on your flight to Knoxville?

What is the cheapest airline that flies from Charleston to Knoxville McGhee Tyson?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Charleston to Knoxville McGhee Tyson

When to book flights from Charleston to Knoxville

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Best Price Found

Fastest flight time

Direct flights

Airports in Knoxville

How far is Charleston to Knoxville McGhee Tyson by plane?

When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

What is the most popular airline from Charleston to Knoxville?

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo

Traveling to a place near Knoxville?

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

How can momondo help me find flights from Charleston to Knoxville?

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Tennessee