What is the cheapest airline that flies from Charleston to Knoxville McGhee Tyson?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Charleston to Knoxville McGhee Tyson

When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

The number of operators available for flights from Charleston Airport to Knoxville McGhee Tyson Airport is 2 as of November 2025.

How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$170 Cheap Flights from Charleston to Knoxville in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Charleston to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:05 am - 10:42 amCHS-TYS

27h 37m2 stops

2:56 pm - 9:23 pmTYS-CHS

6h 27m1 stop

$281Multiple Airlines

Find Deal

mar., dic. 16 - jue., dic. 18

10:18 pm - 8:03 amCHS-TYS

9h 45m1 stop

9:08 am - 9:23 pmTYS-CHS

12h 15m1 stop

$284Multiple Airlines

Find Deal

jue., dic. 18 - lun., dic. 22

7:00 am - 10:42 pmCHS-TYS

15h 42m2 stops

8:53 am - 9:23 pmTYS-CHS

12h 30m1 stop

$300Multiple Airlines

Find Deal

jue., dic. 18 - vie., dic. 19

10:18 pm - 8:03 amCHS-TYS

9h 45m1 stop

9:08 am - 9:23 pmTYS-CHS

12h 15m1 stop

$301Multiple Airlines

Find Deal

jue., dic. 18 - dom., dic. 21

5:27 am - 9:06 amCHS-TYS

3h 39m1 stop

5:30 am - 9:49 amTYS-CHS

4h 19m1 stop

$317Delta

Find Deal

sáb., mar. 7 - mar., mar. 10

5:10 am - 8:36 amCHS-TYS

3h 26m1 stop

5:05 am - 8:38 amTYS-CHS

3h 33m1 stop

$327American Airlines

Find Deal

jue., dic. 11 - dom., dic. 14

5:25 am - 9:38 amCHS-TYS

4h 13m1 stop

3:56 pm - 8:42 amTYS-CHS

16h 46m1 stop

$347Delta

Find Deal

mar., dic. 16 - vie., dic. 19

7:12 pm - 10:55 pmCHS-TYS

3h 43m1 stop

5:40 pm - 10:11 pmTYS-CHS

4h 31m1 stop

$377American Airlines

Find Deal

mar., dic. 16 - lun., dic. 22

7:47 pm - 1:17 pmCHS-TYS

17h 30m2 stops

5:54 pm - 3:10 pmTYS-CHS

21h 16m2 stops

$566United Airlines

Find Deal

vie., dic. 5 - sáb., dic. 6

11:33 am - 9:04 pmCHS-TYS

9h 31m1 stop

5:54 pm - 3:10 pmTYS-CHS

21h 16m2 stops

$594United Airlines

Find Deal

jue., dic. 11 - sáb., dic. 13

American Airlines flights from Charleston to Knoxville

Our best American Airlines deals on Charleston to Knoxville flight tickets

American Airlines

Dec 11

CHS5:10 amCharleston

3h 26m

1 stop

TYS8:36 amKnoxville McGhee Tyson

Dec 14

TYS5:05 amKnoxville McGhee Tyson

3h 33m

1 stop

CHS8:38 amCharleston

$327

Find similar

American Airlines

Dec 16

CHS7:12 pmCharleston

3h 43m

1 stop

TYS10:55 pmKnoxville McGhee Tyson

Dec 22

TYS5:40 pmKnoxville McGhee Tyson

4h 31m

1 stop

CHS10:11 pmCharleston

$377

Find similar

American Airlines

Dec 15

CHS7:12 pmCharleston

3h 43m

1 stop

TYS10:55 pmKnoxville McGhee Tyson

Dec 22

TYS5:40 pmKnoxville McGhee Tyson

4h 31m

1 stop

CHS10:11 pmCharleston

$387

Find similar

United Airlines flights from Charleston to Knoxville

Our best United Airlines deals on Charleston to Knoxville flight tickets

United Airlines

Dec 5

CHS7:47 pmCharleston

17h 30m

2 stops

TYS1:17 pmKnoxville McGhee Tyson

Dec 6

TYS5:54 pmKnoxville McGhee Tyson

21h 16m

2 stops

CHS3:10 pmCharleston

$566

Find similar

United Airlines

Dec 11

CHS11:33 amCharleston

9h 31m

1 stop

TYS9:04 pmKnoxville McGhee Tyson

Dec 13

TYS5:54 pmKnoxville McGhee Tyson

21h 16m

2 stops

CHS3:10 pmCharleston

$594

Find similar

United Airlines

Nov 21

CHS11:06 amCharleston

12h 53m

2 stops

TYS11:59 pmKnoxville McGhee Tyson

Nov 23

TYS5:45 amKnoxville McGhee Tyson

9h 24m

1 stop

CHS3:09 pmCharleston

$637

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

mar. 12/16

7:05 am-10:42 am

2 stops27h 37m

Knoxville McGhee Tyson

jue. 12/18

2:56 pm-9:23 pm

1 stop6h 27m

$281

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

jue. 12/18

10:18 pm-8:03 am

1 stop9h 45m

Knoxville McGhee Tyson

lun. 12/22

9:08 am-9:23 pm

1 stop12h 15m

$284

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

jue. 12/18

7:00 am-10:42 pm

2 stops15h 42m

Knoxville McGhee Tyson

vie. 12/19

8:53 am-9:23 pm

1 stop12h 30m

$300

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

jue. 12/18

10:18 pm-8:03 am

1 stop9h 45m

Knoxville McGhee Tyson

dom. 12/21

9:08 am-9:23 pm

1 stop12h 15m

$301

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

sáb. 3/7

5:27 am-9:06 am

1 stop3h 39m

Knoxville McGhee Tyson

mar. 3/10

5:30 am-9:49 am

1 stop4h 19m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

jue. 12/11

5:10 am-8:36 am

1 stop3h 26m

Knoxville McGhee Tyson

dom. 12/14

5:05 am-8:38 am

1 stop3h 33m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

mar. 12/16

5:25 am-9:38 am

1 stop4h 13m

Knoxville McGhee Tyson

vie. 12/19

3:56 pm-8:42 am

1 stop16h 46m

$347

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

mar. 12/16

7:12 pm-10:55 pm

1 stop3h 43m

Knoxville McGhee Tyson

lun. 12/22

5:40 pm-10:11 pm

1 stop4h 31m

$377

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 12/5

7:47 pm-1:17 pm

2 stops17h 30m

Knoxville McGhee Tyson

sáb. 12/6

5:54 pm-3:10 pm

2 stops21h 16m

$566

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

jue. 12/11

11:33 am-9:04 pm

1 stop9h 31m

Knoxville McGhee Tyson

sáb. 12/13

5:54 pm-3:10 pm

2 stops21h 16m

$594

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Charleston, with most prices found around $356. If you aren’t able to travel during the month of June, then book flights to Knoxville from Charleston during May instead. Flights to Knoxville in May, while not as cheap as those in June, still average around $366.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Charleston to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $464. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Knoxville for around $780.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Charleston to Knoxville when you can find flight prices for as low as $525. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $696.

When to book flights from Charleston to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Direct flights	None

There are no direct flights from Charleston to Knoxville. There are no popular flight routes from Charleston to Knoxville.

Search flight deals

How far is Charleston to Knoxville McGhee Tyson by plane?
A flight from Charleston to Knoxville McGhee Tyson will travel around 316.2 mi. Flights usually cover this in 3h 07m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?
The number of operators available for flights from Charleston Airport to Knoxville McGhee Tyson Airport is 2 as of November 2025.
How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Charleston to Knoxville?
momondo data reveals that the most frequently booked airline on the route from Charleston to Knoxville is American Airlines, representing 59% of all bookings. The subsequent popular airline is Delta at 41%.

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $326	Free Cancellation	Rating 7.2 11,042 reviews		Search American Airlines flights
Delta	PriceFrom $326	Free Cancellation	Rating 7.9 8,004 reviews		Search Delta flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Alcoa

Oak Ridge

Newport

Lenoir City

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

It is quick and easy to find Charleston to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Charleston to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Charleston to Knoxville?

Once you have performed a search for Charleston to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

sáb. 12/6

sáb. 12/13

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States

Airports servicing Tennessee

Nashville Intl Airport

Chattanooga Lovell Field Airport

Memphis Airport

Jackson Mckellar Field Airport

Blountville Tri Cities TN/VA Airport

Popular cities in the United States

Flights to New Yorkfrom $49

Flights to Los Angelesfrom $49

Flights to Miamifrom $49

Flights to Chicagofrom $58

Flights to Orlandofrom $49

Flights to Las Vegasfrom $42

Flights to San Franciscofrom $57

Flights to Washington, D.C.from $54

Flights to Bostonfrom $49

Flights to Atlantafrom $49

Flights to Dallasfrom $58

Flights to Seattlefrom $72

Cheap flights from Charleston to Knoxville from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Knoxville departing on 11/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Charleston to Knoxville

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

American Airlines flights from Charleston to Knoxville

Our best American Airlines deals on Charleston to Knoxville flight tickets

United Airlines flights from Charleston to Knoxville

Our best United Airlines deals on Charleston to Knoxville flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

See travel insights to Knoxville from

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

What is the cheapest day to depart on your flight to Knoxville?

What is the cheapest time of day to depart on your flight to Knoxville?

What is the cheapest airline that flies from Charleston to Knoxville McGhee Tyson?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Charleston to Knoxville McGhee Tyson

When to book flights from Charleston to Knoxville

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Direct flights

How far is Charleston to Knoxville McGhee Tyson by plane?

When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

What is the most popular airline from Charleston to Knoxville?

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo

Traveling to a place near Knoxville?

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

How can momondo help me find flights from Charleston to Knoxville?

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Tennessee