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Cheap flights from Charleston to Knoxville from $150

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Knoxville departing on 4/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Charleston to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:40 am - 12:00 pm
CHS
-
TYS
5h 20m
1 stop
Southwest Logo
8:15 am - 1:35 pm
TYS
-
CHS
5h 20m
1 stop
$221Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
Southwest Logo
8:15 am - 1:35 pm
TYS
-
CHS
5h 20m
1 stop
$226Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
Southwest Logo
8:15 am - 5:40 pm
TYS
-
CHS
9h 25m
2 stops
$231Southwest
Tue, May 5 - Tue, May 12
Multiple Airlines Logo
8:07 am - 10:05 pm
CHS
-
TYS
13h 58m
1 stop
Multiple Airlines Logo
1:15 pm - 8:38 am
TYS
-
CHS
19h 23m
1 stop
$253Multiple Airlines
Thu, Apr 9 - Mon, Apr 13
American Airlines Logo
5:00 am - 8:32 am
CHS
-
TYS
3h 32m
1 stop
American Airlines Logo
5:57 pm - 11:59 pm
TYS
-
CHS
6h 02m
1 stop
$286American Airlines
Thu, May 7 - Mon, May 11
Multiple Airlines Logo
8:07 am - 10:36 am
CHS
-
TYS
26h 29m
1 stop
Multiple Airlines Logo
9:00 am - 5:44 pm
TYS
-
CHS
32h 44m
2 stops
$289Multiple Airlines
Tue, Apr 14 - Sat, Apr 18
Multiple Airlines Logo
8:59 pm - 1:16 pm
CHS
-
TYS
16h 17m
2 stops
Multiple Airlines Logo
1:15 pm - 8:38 am
TYS
-
CHS
19h 23m
1 stop
$290Multiple Airlines
Thu, Apr 9 - Mon, Apr 13
American Airlines Logo
8:21 pm - 11:55 pm
CHS
-
TYS
3h 34m
1 stop
American Airlines Logo
5:00 am - 8:31 am
TYS
-
CHS
3h 31m
1 stop
$299American Airlines
Thu, May 7 - Thu, May 14
American Airlines Logo
5:00 am - 8:34 am
CHS
-
TYS
3h 34m
1 stop
American Airlines Logo
5:43 pm - 11:59 pm
TYS
-
CHS
6h 16m
1 stop
$301American Airlines
Sat, May 23 - Sun, May 24
American Airlines Logo
5:00 am - 8:32 am
CHS
-
TYS
3h 32m
1 stop
American Airlines Logo
5:57 pm - 11:59 pm
TYS
-
CHS
6h 02m
1 stop
$307American Airlines
Fri, May 8 - Mon, May 11

Southwest flights from Charleston to Knoxville

Our best Southwest deals on Charleston to Knoxville flight tickets
Southwest
May 5
CHS6:40 amCharleston
5h 20m
1 stop
TYS12:00 pmKnoxville McGhee Tyson
May 12
TYS8:15 amKnoxville McGhee Tyson
5h 20m
1 stop
CHS1:35 pmCharleston
$221
Southwest
May 5
CHS12:00 pmCharleston
8h 50m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
May 12
TYS8:15 amKnoxville McGhee Tyson
5h 20m
1 stop
CHS1:35 pmCharleston
$226
Southwest
May 5
CHS12:00 pmCharleston
8h 50m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
May 12
TYS8:15 amKnoxville McGhee Tyson
9h 25m
2 stops
CHS5:40 pmCharleston
$231

American Airlines flights from Charleston to Knoxville

Our best American Airlines deals on Charleston to Knoxville flight tickets
American Airlines
May 7
CHS5:00 amCharleston
3h 32m
1 stop
TYS8:32 amKnoxville McGhee Tyson
May 11
TYS5:57 pmKnoxville McGhee Tyson
6h 02m
1 stop
CHS11:59 pmCharleston
$286
American Airlines
May 7
CHS8:21 pmCharleston
3h 34m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
May 14
TYS5:00 amKnoxville McGhee Tyson
3h 31m
1 stop
CHS8:31 amCharleston
$299
American Airlines
May 23
CHS5:00 amCharleston
3h 34m
1 stop
TYS8:34 amKnoxville McGhee Tyson
May 24
TYS5:43 pmKnoxville McGhee Tyson
6h 16m
1 stop
CHS11:59 pmCharleston
$301

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 5/5

6:40 am-12:00 pm

1 stop5h 20m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-1:35 pm

1 stop5h 20m

$221

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 5/5

12:00 pm-8:50 pm

2 stops8h 50m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-1:35 pm

1 stop5h 20m

$226

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 5/5

12:00 pm-8:50 pm

2 stops8h 50m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-5:40 pm

2 stops9h 25m

$231

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 4/9

8:07 am-10:05 pm

1 stop13h 58m

Knoxville McGhee Tyson

Mon 4/13

1:15 pm-8:38 am

1 stop19h 23m

$253

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/7

5:00 am-8:32 am

1 stop3h 32m

Knoxville McGhee Tyson

Mon 5/11

5:57 pm-11:59 pm

1 stop6h 02m

$286

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 4/14

8:07 am-10:36 am

1 stop26h 29m

Knoxville McGhee Tyson

Sat 4/18

9:00 am-5:44 pm

2 stops32h 44m

$289

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 4/9

8:59 pm-1:16 pm

2 stops16h 17m

Knoxville McGhee Tyson

Mon 4/13

1:15 pm-8:38 am

1 stop19h 23m

$290
Quickest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/7

8:21 pm-11:55 pm

1 stop3h 34m

Knoxville McGhee Tyson

Thu 5/14

5:00 am-8:31 am

1 stop3h 31m

$299

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 5/23

5:00 am-8:34 am

1 stop3h 34m

Knoxville McGhee Tyson

Sun 5/24

5:43 pm-11:59 pm

1 stop6h 16m

$301

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 5/8

5:00 am-8:32 am

1 stop3h 32m

Knoxville McGhee Tyson

Mon 5/11

5:57 pm-11:59 pm

1 stop6h 02m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Knoxville?

When to book flights from Charleston to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Fastest flight time

3h 19m

Direct flights

None
The fastest flight from Charleston to Knoxville takes 3h 19m
There are no direct flights from Charleston to Knoxville. There are no popular flight routes from Charleston to Knoxville.
Search flight deals

  • How far is Charleston to Knoxville McGhee Tyson by plane?

    A flight from Charleston to Knoxville McGhee Tyson will travel around 316.2 mi. Flights usually cover this in 3h 19m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Knoxville?

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,358 reviews
Search Delta flights
American AirlinesPriceFrom $316Free CancellationRating
7.1
11,530 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

It is quick and easy to find Charleston to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Charleston to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Charleston to Knoxville?

Once you have performed a search for Charleston to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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