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Cheap flights from Charleston to Knoxville from $140

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Knoxville departing on 3/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:00 pm - 12:00 pm
CHS
-
TYS
19h 00m
1 stop
Multiple Airlines Logo
8:54 pm - 9:35 am
TYS
-
CHS
12h 41m
1 stop
$213Multiple Airlines
do, mrt. 5 - ma, mrt. 9
Multiple Airlines Logo
6:35 pm - 12:00 pm
CHS
-
TYS
17h 25m
2 stops
Multiple Airlines Logo
8:54 pm - 9:35 am
TYS
-
CHS
12h 41m
1 stop
$234Multiple Airlines
do, mrt. 5 - ma, mrt. 9
Multiple Airlines Logo
8:07 am - 8:51 pm
CHS
-
TYS
12h 44m
1 stop
Multiple Airlines Logo
9:26 am - 10:13 pm
TYS
-
CHS
12h 47m
1 stop
$255Multiple Airlines
za, mrt. 28 - za, apr. 4
Multiple Airlines Logo
3:01 pm - 6:26 pm
CHS
-
TYS
27h 25m
1 stop
Multiple Airlines Logo
8:54 pm - 11:35 am
TYS
-
CHS
14h 41m
1 stop
$273Multiple Airlines
di, mrt. 3 - vr, mrt. 6
Multiple Airlines Logo
5:16 pm - 1:16 pm
CHS
-
TYS
44h 00m
2 stops
Multiple Airlines Logo
9:26 am - 10:13 pm
TYS
-
CHS
12h 47m
1 stop
$297Multiple Airlines
za, mrt. 28 - za, apr. 4
Multiple Airlines Logo
5:00 pm - 3:04 pm
CHS
-
TYS
22h 04m
2 stops
Multiple Airlines Logo
8:54 pm - 11:35 am
TYS
-
CHS
14h 41m
1 stop
$301Multiple Airlines
di, mrt. 3 - vr, mrt. 6
Multiple Airlines Logo
5:02 pm - 10:06 am
CHS
-
TYS
17h 04m
2 stops
Multiple Airlines Logo
8:00 am - 5:40 pm
TYS
-
CHS
9h 40m
1 stop
$316Multiple Airlines
di, feb. 24 - za, feb. 28
Southwest Logo
4:45 pm - 9:15 pm
CHS
-
TYS
4h 30m
1 stop
Southwest Logo
6:40 am - 12:00 pm
TYS
-
CHS
5h 20m
1 stop
$317Southwest
vr, apr. 17 - zo, apr. 19
Multiple Airlines Logo
5:02 pm - 10:06 am
CHS
-
TYS
17h 04m
2 stops
Multiple Airlines Logo
8:00 am - 5:40 pm
TYS
-
CHS
9h 40m
1 stop
$321Multiple Airlines
di, feb. 24 - za, feb. 28
Southwest Logo
8:05 am - 6:10 pm
CHS
-
TYS
10h 05m
2 stops
Southwest Logo
6:40 am - 12:00 pm
TYS
-
CHS
5h 20m
1 stop
$322Southwest
vr, apr. 17 - zo, apr. 19

Delta flights from Charleston to Knoxville

Our best Delta deals on Charleston to Knoxville flight tickets
Delta
Feb 24
CHS7:30 amCharleston
3h 38m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Feb 28
TYS2:37 pmKnoxville McGhee Tyson
3h 17m
1 stop
CHS5:54 pmCharleston
$407
Delta
Feb 18
CHS7:30 amCharleston
3h 38m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Feb 25
TYS5:35 amKnoxville McGhee Tyson
3h 48m
1 stop
CHS9:23 amCharleston
$436
Delta
Feb 24
CHS3:07 pmCharleston
4h 53m
1 stop
TYS8:00 pmKnoxville McGhee Tyson
Feb 28
TYS5:00 pmKnoxville McGhee Tyson
2h 56m
1 stop
CHS7:56 pmCharleston
$446

American Airlines flights from Charleston to Knoxville

Our best American Airlines deals on Charleston to Knoxville flight tickets
American Airlines
Apr 15
CHS8:21 pmCharleston
3h 34m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Apr 16
TYS2:06 pmKnoxville McGhee Tyson
5h 23m
1 stop
CHS7:29 pmCharleston
$459
American Airlines
Feb 18
CHS6:05 amCharleston
3h 48m
1 stop
TYS9:53 amKnoxville McGhee Tyson
Feb 24
TYS5:47 pmKnoxville McGhee Tyson
3h 40m
1 stop
CHS9:27 pmCharleston
$465
American Airlines
Mar 2
CHS1:12 pmCharleston
5h 01m
1 stop
TYS6:13 pmKnoxville McGhee Tyson
Mar 4
TYS5:47 pmKnoxville McGhee Tyson
3h 35m
1 stop
CHS9:22 pmCharleston
$565

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated februari 12, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

do 3/5

5:00 pm-12:00 pm

1 stop19h 00m

Knoxville McGhee Tyson

ma 3/9

8:54 pm-9:35 am

1 stop12h 41m

$213

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

do 3/5

6:35 pm-12:00 pm

2 stops17h 25m

Knoxville McGhee Tyson

ma 3/9

8:54 pm-9:35 am

1 stop12h 41m

$234

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

za 3/28

8:07 am-8:51 pm

1 stop12h 44m

Knoxville McGhee Tyson

za 4/4

9:26 am-10:13 pm

1 stop12h 47m

$255

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

di 3/3

3:01 pm-6:26 pm

1 stop27h 25m

Knoxville McGhee Tyson

vr 3/6

8:54 pm-11:35 am

1 stop14h 41m

$273

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

za 3/28

5:16 pm-1:16 pm

2 stops44h 00m

Knoxville McGhee Tyson

za 4/4

9:26 am-10:13 pm

1 stop12h 47m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

di 3/3

5:00 pm-3:04 pm

2 stops22h 04m

Knoxville McGhee Tyson

vr 3/6

8:54 pm-11:35 am

1 stop14h 41m

$301

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

di 2/24

5:02 pm-10:06 am

2 stops17h 04m

Knoxville McGhee Tyson

za 2/28

8:00 am-5:40 pm

1 stop9h 40m

$316

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vr 4/17

4:45 pm-9:15 pm

1 stop4h 30m

Knoxville McGhee Tyson

zo 4/19

6:40 am-12:00 pm

1 stop5h 20m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

di 2/24

5:02 pm-10:06 am

2 stops17h 04m

Knoxville McGhee Tyson

za 2/28

8:00 am-5:40 pm

1 stop9h 40m

$321

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vr 4/17

8:05 am-6:10 pm

2 stops10h 05m

Knoxville McGhee Tyson

zo 4/19

6:40 am-12:00 pm

1 stop5h 20m

$322

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Charleston to Knoxville McGhee Tyson?

Delta and Southwest are the most popular carriers operating from Charleston to Knoxville McGhee Tyson

When to book flights from Charleston to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Fastest flight time

5h 20m

Direct flights

None
The fastest flight from Charleston to Knoxville takes 5h 20m
There are no direct flights from Charleston to Knoxville. There are no popular flight routes from Charleston to Knoxville.
Search flight deals

  • How far is Charleston to Knoxville McGhee Tyson by plane?

    A flight from Charleston to Knoxville McGhee Tyson will travel around 316.2 mi. Flights usually cover this in 5h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Knoxville?

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,180 reviews
Search Delta flights
American AirlinesPriceFrom $316Free CancellationRating
7.2
11,271 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

It is quick and easy to find Charleston to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Charleston to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Charleston to Knoxville?

Once you have performed a search for Charleston to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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