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Cheap flights from Charleston to Knoxville from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Knoxville departing on 5/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:27 pm - 2:21 pm
CHS
-
TYS
19h 54m
2 stops
Multiple Airlines Logo
6:29 pm - 8:38 am
TYS
-
CHS
14h 09m
1 stop
$247Multiple Airlines
Thu, Aug 6 - Mon, Aug 17
Multiple Airlines Logo
7:47 pm - 8:36 am
CHS
-
TYS
12h 49m
1 stop
Multiple Airlines Logo
6:29 pm - 8:38 am
TYS
-
CHS
14h 09m
1 stop
$264Multiple Airlines
Thu, Aug 6 - Mon, Aug 17
Multiple Airlines Logo
2:53 pm - 11:06 pm
CHS
-
TYS
8h 13m
1 stop
Multiple Airlines Logo
6:00 am - 8:38 am
TYS
-
CHS
26h 38m
1 stop
$277Multiple Airlines
Thu, May 28 - Sat, May 30
Multiple Airlines Logo
2:53 pm - 11:06 pm
CHS
-
TYS
8h 13m
1 stop
Multiple Airlines Logo
1:45 pm - 5:35 pm
TYS
-
CHS
27h 50m
2 stops
$312Multiple Airlines
Thu, May 28 - Sat, May 30
Southwest Logo
2:10 pm - 8:20 pm
CHS
-
TYS
6h 10m
1 stop
Southwest Logo
7:30 am - 1:15 pm
TYS
-
CHS
5h 45m
1 stop
$313Southwest
Tue, Jul 7 - Thu, Jul 9
Delta Logo
8:25 am - 1:10 pm
CHS
-
TYS
4h 45m
1 stop
Delta Logo
5:40 am - 8:43 am
TYS
-
CHS
3h 03m
1 stop
$316Delta
Fri, May 29 - Wed, Jun 3
Southwest Logo
2:10 pm - 8:20 pm
CHS
-
TYS
6h 10m
1 stop
Southwest Logo
7:30 am - 3:35 pm
TYS
-
CHS
8h 05m
2 stops
$318Southwest
Tue, Jul 7 - Thu, Jul 9
American Airlines Logo
10:52 am - 3:15 pm
CHS
-
TYS
4h 23m
1 stop
American Airlines Logo
7:59 pm - 11:59 pm
TYS
-
CHS
4h 00m
1 stop
$321American Airlines
Thu, Jun 25 - Sat, Jun 27
Multiple Airlines Logo
3:23 pm - 11:38 pm
CHS
-
TYS
8h 15m
1 stop
Multiple Airlines Logo
7:01 pm - 8:45 am
TYS
-
CHS
13h 44m
1 stop
$327Multiple Airlines
Fri, Jun 19 - Sun, Jun 21
American Airlines Logo
5:00 am - 8:34 am
CHS
-
TYS
3h 34m
1 stop
American Airlines Logo
5:00 am - 10:07 am
TYS
-
CHS
5h 07m
1 stop
$329American Airlines
Mon, Jun 22 - Sun, Jun 28

American Airlines flights from Charleston to Knoxville

Our best American Airlines deals on Charleston to Knoxville flight tickets
American Airlines
Jun 25
CHS10:52 amCharleston
4h 23m
1 stop
TYS3:15 pmKnoxville McGhee Tyson
Jun 27
TYS7:59 pmKnoxville McGhee Tyson
4h 00m
1 stop
CHS11:59 pmCharleston
$321
American Airlines
Jun 22
CHS5:00 amCharleston
3h 34m
1 stop
TYS8:34 amKnoxville McGhee Tyson
Jun 28
TYS5:00 amKnoxville McGhee Tyson
5h 07m
1 stop
CHS10:07 amCharleston
$329
American Airlines
Jun 25
CHS10:52 amCharleston
4h 23m
1 stop
TYS3:15 pmKnoxville McGhee Tyson
Jun 27
TYS6:07 pmKnoxville McGhee Tyson
5h 52m
1 stop
CHS11:59 pmCharleston
$331

Delta flights from Charleston to Knoxville

Our best Delta deals on Charleston to Knoxville flight tickets
Delta
May 29
CHS8:25 amCharleston
4h 45m
1 stop
TYS1:10 pmKnoxville McGhee Tyson
Jun 3
TYS5:40 amKnoxville McGhee Tyson
3h 03m
1 stop
CHS8:43 amCharleston
$316
Delta
Jun 12
CHS5:10 amCharleston
4h 28m
1 stop
TYS9:38 amKnoxville McGhee Tyson
Jun 14
TYS7:46 pmKnoxville McGhee Tyson
4h 50m
1 stop
CHS12:36 amCharleston
$337
Delta
Jun 5
CHS5:15 amCharleston
4h 19m
1 stop
TYS9:34 amKnoxville McGhee Tyson
Jun 7
TYS7:46 pmKnoxville McGhee Tyson
4h 50m
1 stop
CHS12:36 amCharleston
$382

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 8/6

6:27 pm-2:21 pm

2 stops19h 54m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-8:38 am

1 stop14h 09m

$247

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 8/6

7:47 pm-8:36 am

1 stop12h 49m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-8:38 am

1 stop14h 09m

$264

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/28

2:53 pm-11:06 pm

1 stop8h 13m

Knoxville McGhee Tyson

Sat 5/30

6:00 am-8:38 am

1 stop26h 38m

$277

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/28

2:53 pm-11:06 pm

1 stop8h 13m

Knoxville McGhee Tyson

Sat 5/30

1:45 pm-5:35 pm

2 stops27h 50m

$312

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 7/7

2:10 pm-8:20 pm

1 stop6h 10m

Knoxville McGhee Tyson

Thu 7/9

7:30 am-1:15 pm

1 stop5h 45m

$313
Quickest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 5/29

8:25 am-1:10 pm

1 stop4h 45m

Knoxville McGhee Tyson

Wed 6/3

5:40 am-8:43 am

1 stop3h 03m

$316

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 7/7

2:10 pm-8:20 pm

1 stop6h 10m

Knoxville McGhee Tyson

Thu 7/9

7:30 am-3:35 pm

2 stops8h 05m

$318

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 6/25

10:52 am-3:15 pm

1 stop4h 23m

Knoxville McGhee Tyson

Sat 6/27

7:59 pm-11:59 pm

1 stop4h 00m

$321

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 6/19

3:23 pm-11:38 pm

1 stop8h 15m

Knoxville McGhee Tyson

Sun 6/21

7:01 pm-8:45 am

1 stop13h 44m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 6/22

5:00 am-8:34 am

1 stop3h 34m

Knoxville McGhee Tyson

Sun 6/28

5:00 am-10:07 am

1 stop5h 07m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Charleston, with most prices found around $0. If you aren’t able to travel during the month of March, then book flights to Knoxville from Charleston during January instead. Flights to Knoxville in January, while not as cheap as those in March, still average around $254.

When to book flights from Charleston to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Fastest flight time

4h 19m

Direct flights

None
The fastest flight from Charleston to Knoxville takes 4h 19m
There are no direct flights from Charleston to Knoxville. There are no popular flight routes from Charleston to Knoxville.
Search flight deals

Frequently asked questions about flying from Charleston to Knoxville

  • How far is Charleston to Knoxville McGhee Tyson by plane?

    A flight from Charleston to Knoxville McGhee Tyson will travel around 316.2 mi. Flights usually cover this in 4h 19m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Charleston to Knoxville?

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $316Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

It is quick and easy to find Charleston to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Charleston to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Charleston to Knoxville?

Once you have performed a search for Charleston to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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