When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?

The number of operators available for flights from Charleston Airport to Knoxville McGhee Tyson Airport is 2 as of December 2025.

How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$254 Cheap Flights from Charleston to Knoxville in 2025/26

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2:15 pm - 8:39 am

CHS

TYS

18h 24m2 stops

9:29 am - 5:36 pm

TYS

CHS

8h 07m1 stop

$254Multiple Airlines

Wed, Jan 7 - Sun, Jan 11

10:31 am - 1:50 pm

CHS

TYS

3h 19m1 stop

5:40 am - 11:48 am

TYS

CHS

6h 08m1 stop

$255Delta

Wed, Jan 21 - Wed, Jan 28

2:15 pm - 8:39 am

CHS

TYS

18h 24m3 stops

9:29 am - 5:36 pm

TYS

CHS

8h 07m1 stop

$281Multiple Airlines

Wed, Jan 7 - Sun, Jan 11

7:05 am - 10:21 pm

CHS

TYS

15h 16m2 stops

11:59 am - 5:36 pm

TYS

CHS

5h 37m1 stop

$286Multiple Airlines

Fri, Jan 23 - Sat, Jan 24

10:31 am - 1:50 pm

CHS

TYS

3h 19m1 stop

5:40 am - 11:48 am

TYS

CHS

6h 08m1 stop

$301Delta

Sat, Jan 24 - Sun, Jan 25

7:00 am - 10:26 pm

CHS

TYS

15h 26m1 stop

5:24 pm - 11:26 pm

TYS

CHS

6h 02m1 stop

$302Multiple Airlines

Thu, Mar 19 - Sun, Mar 22

6:30 am - 11:08 am

CHS

TYS

4h 38m1 stop

5:35 am - 9:23 am

TYS

CHS

3h 48m1 stop

$311Delta

Sat, Feb 14 - Fri, Feb 20

7:00 am - 10:26 pm

CHS

TYS

15h 26m1 stop

9:43 pm - 2:41 pm

TYS

CHS

16h 58m2 stops

$323Multiple Airlines

Thu, Mar 19 - Sun, Mar 22

2:15 pm - 8:39 am

CHS

TYS

18h 24m2 stops

9:29 am - 4:10 pm

TYS

CHS

30h 41m3 stops

$329Multiple Airlines

Wed, Jan 7 - Sun, Jan 11

2:15 pm - 8:39 am

CHS

TYS

18h 24m3 stops

9:29 am - 4:10 pm

TYS

CHS

30h 41m3 stops

$354Multiple Airlines

Wed, Jan 7 - Sun, Jan 11

Delta flights from Charleston to Knoxville

Our best Delta deals on Charleston to Knoxville flight tickets

Delta

Jan 21

CHS9:00 amCharleston

4h 50m

1 stop

TYS1:50 pmKnoxville McGhee Tyson

Jan 28

TYS5:40 amKnoxville McGhee Tyson

3h 46m

1 stop

CHS9:26 amCharleston

$255

Find similar

Delta

Feb 14

CHS5:27 amCharleston

5h 41m

1 stop

TYS11:08 amKnoxville McGhee Tyson

Feb 20

TYS6:41 pmKnoxville McGhee Tyson

5h 13m

1 stop

CHS11:54 pmCharleston

$301

Find similar

Delta

Feb 14

CHS7:30 amCharleston

3h 38m

1 stop

TYS11:08 amKnoxville McGhee Tyson

Feb 20

TYS2:38 pmKnoxville McGhee Tyson

5h 18m

1 stop

CHS7:56 pmCharleston

$311

Find similar

Southwest flights from Charleston to Knoxville

Our best Southwest deals on Charleston to Knoxville flight tickets

Southwest

Apr 9

CHS8:05 amCharleston

10h 05m

2 stops

TYS6:10 pmKnoxville McGhee Tyson

Apr 19

TYS7:45 amKnoxville McGhee Tyson

5h 40m

1 stop

CHS1:25 pmCharleston

$337

Find similar

Southwest

Apr 9

CHS1:15 pmCharleston

8h 00m

2 stops

TYS9:15 pmKnoxville McGhee Tyson

Apr 19

TYS6:40 amKnoxville McGhee Tyson

9h 20m

2 stops

CHS4:00 pmCharleston

$342

Find similar

Southwest

Mar 26

CHS4:30 pmCharleston

5h 40m

1 stop

TYS10:10 pmKnoxville McGhee Tyson

Mar 29

TYS7:25 pmKnoxville McGhee Tyson

14h 35m

2 stops

CHS10:00 amCharleston

$373

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 1/7

2:15 pm-8:39 am

2 stops18h 24m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-5:36 pm

1 stop8h 07m

$254

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 1/21

10:31 am-1:50 pm

1 stop3h 19m

Knoxville McGhee Tyson

Wed 1/28

5:40 am-11:48 am

1 stop6h 08m

$255

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 1/7

2:15 pm-8:39 am

3 stops18h 24m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-5:36 pm

1 stop8h 07m

$281

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 1/23

7:05 am-10:21 pm

2 stops15h 16m

Knoxville McGhee Tyson

Sat 1/24

11:59 am-5:36 pm

1 stop5h 37m

$286

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 1/24

10:31 am-1:50 pm

1 stop3h 19m

Knoxville McGhee Tyson

Sun 1/25

5:40 am-11:48 am

1 stop6h 08m

$301

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 3/19

7:00 am-10:26 pm

1 stop15h 26m

Knoxville McGhee Tyson

Sun 3/22

5:24 pm-11:26 pm

1 stop6h 02m

$302

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 2/14

6:30 am-11:08 am

1 stop4h 38m

Knoxville McGhee Tyson

Fri 2/20

5:35 am-9:23 am

1 stop3h 48m

$311

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 3/19

7:00 am-10:26 pm

1 stop15h 26m

Knoxville McGhee Tyson

Sun 3/22

9:43 pm-2:41 pm

2 stops16h 58m

$323

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 1/7

2:15 pm-8:39 am

2 stops18h 24m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-4:10 pm

3 stops30h 41m

$329

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 1/7

2:15 pm-8:39 am

3 stops18h 24m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-4:10 pm

3 stops30h 41m

$354

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Charleston to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Charleston to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $464. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Knoxville for around $780.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Charleston to Knoxville when you can find flight prices for as low as $525. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $696.

When to book flights from Charleston to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Charleston to Knoxville (CHS to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Knoxville

Fastest flight time	4h 50m
Direct flights	None

The fastest flight from Charleston to Knoxville takes 4h 50m

There are no direct flights from Charleston to Knoxville. There are no popular flight routes from Charleston to Knoxville.

Search flight deals

How far is Charleston to Knoxville McGhee Tyson by plane?
A flight from Charleston to Knoxville McGhee Tyson will travel around 316.2 mi. Flights usually cover this in 4h 50m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Charleston Airport to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from Charleston Airport to Knoxville McGhee Tyson Airport?
The number of operators available for flights from Charleston Airport to Knoxville McGhee Tyson Airport is 2 as of December 2025.
How old do you have to be to fly from Charleston Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Charleston to Knoxville?
momondo data reveals that the most frequently booked airline on the route from Charleston to Knoxville is American Airlines, representing 54% of all bookings. The subsequent popular airline is Delta at 46%.

Best airlines flying from Charleston to Knoxville

Compare and see reviews for airlines that fly from Charleston to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $316	Free Cancellation	Rating 7.2 11,056 reviews		Search American Airlines flights
Delta	PriceFrom $326	Free Cancellation	Rating 7.9 8,011 reviews		Search Delta flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Maryville

Crossville

Murphy

Alcoa

Oak Ridge

Newport

Lenoir City

Kodak

Dandridge

Jefferson City

Clinton

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Knoxville?

It is quick and easy to find Charleston to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Charleston to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Charleston to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Charleston to Knoxville?

Once you have performed a search for Charleston to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Charleston to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.