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Cheap flights from Charleston to Des Moines from $151

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Des Moines departing on 7/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Charleston to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:30 am - 11:35 am
CHS
-
DSM
7h 05m
1 stop
Southwest Logo
3:45 pm - 9:25 pm
DSM
-
CHS
4h 40m
1 stop
$371Southwest
Sat, Jun 6 - Tue, Jun 9
Southwest Logo
7:40 am - 11:45 am
CHS
-
DSM
5h 05m
1 stop
Southwest Logo
4:20 pm - 9:55 pm
DSM
-
CHS
4h 35m
1 stop
$375Southwest
Thu, May 28 - Mon, Jun 1
Southwest Logo
2:15 pm - 11:05 pm
CHS
-
DSM
9h 50m
2 stops
Southwest Logo
4:20 pm - 9:55 pm
DSM
-
CHS
4h 35m
1 stop
$380Southwest
Thu, May 28 - Mon, Jun 1
United Airlines Logo
6:00 am - 10:37 am
CHS
-
DSM
5h 37m
1 stop
United Airlines Logo
5:00 am - 12:17 pm
DSM
-
CHS
6h 17m
1 stop
$391United Airlines
Fri, May 15 - Mon, May 18
United Airlines Logo
6:50 am - 2:20 pm
CHS
-
DSM
8h 30m
1 stop
United Airlines Logo
6:00 am - 2:27 pm
DSM
-
CHS
7h 27m
2 stops
$392United Airlines
Sat, Jun 6 - Tue, Jun 9
Southwest Logo
7:40 am - 11:45 am
CHS
-
DSM
5h 05m
1 stop
Southwest Logo
5:20 am - 4:00 pm
DSM
-
CHS
9h 40m
1 stop
$396Southwest
Thu, May 28 - Sun, May 31
American Airlines Logo
7:52 pm - 12:12 am
CHS
-
DSM
5h 20m
1 stop
American Airlines Logo
1:37 pm - 7:50 pm
DSM
-
CHS
5h 13m
1 stop
$398American Airlines
Sat, Jun 6 - Tue, Jun 9
United Airlines Logo
6:53 pm - 11:24 pm
CHS
-
DSM
5h 31m
1 stop
United Airlines Logo
6:15 am - 12:17 pm
DSM
-
CHS
5h 02m
1 stop
$401United Airlines
Fri, May 15 - Mon, May 18
Southwest Logo
7:40 am - 11:45 am
CHS
-
DSM
5h 05m
1 stop
Southwest Logo
5:20 am - 5:30 pm
DSM
-
CHS
11h 10m
2 stops
$402Southwest
Thu, May 28 - Sun, May 31
United Airlines Logo
4:16 pm - 11:24 pm
CHS
-
DSM
8h 08m
1 stop
United Airlines Logo
11:23 am - 5:45 pm
DSM
-
CHS
5h 22m
1 stop
$407United Airlines
Fri, Jul 3 - Tue, Jul 7

United Airlines flights from Charleston to Des Moines

Our best United Airlines deals on Charleston to Des Moines flight tickets
United Airlines
May 15
CHS6:00 amCharleston
5h 37m
1 stop
DSM10:37 amDes Moines
May 18
DSM5:00 amDes Moines
6h 17m
1 stop
CHS12:17 pmCharleston
$391
United Airlines
Jun 6
CHS6:50 amCharleston
8h 30m
1 stop
DSM2:20 pmDes Moines
Jun 9
DSM6:00 amDes Moines
7h 27m
2 stops
CHS2:27 pmCharleston
$392
United Airlines
May 15
CHS6:53 pmCharleston
5h 31m
1 stop
DSM11:24 pmDes Moines
May 18
DSM6:15 amDes Moines
5h 02m
1 stop
CHS12:17 pmCharleston
$401

Southwest flights from Charleston to Des Moines

Our best Southwest deals on Charleston to Des Moines flight tickets
Southwest
Jun 6
CHS5:30 amCharleston
7h 05m
1 stop
DSM11:35 amDes Moines
Jun 9
DSM3:45 pmDes Moines
4h 40m
1 stop
CHS9:25 pmCharleston
$371
Southwest
May 28
CHS7:40 amCharleston
5h 05m
1 stop
DSM11:45 amDes Moines
Jun 1
DSM4:20 pmDes Moines
4h 35m
1 stop
CHS9:55 pmCharleston
$375
Southwest
May 28
CHS2:15 pmCharleston
9h 50m
2 stops
DSM11:05 pmDes Moines
Jun 1
DSM4:20 pmDes Moines
4h 35m
1 stop
CHS9:55 pmCharleston
$380

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 6/6

5:30 am-11:35 am

1 stop7h 05m

Des Moines

Tue 6/9

3:45 pm-9:25 pm

1 stop4h 40m

$371
Quickest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 5/28

7:40 am-11:45 am

1 stop5h 05m

Des Moines

Mon 6/1

4:20 pm-9:55 pm

1 stop4h 35m

$375

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 5/28

2:15 pm-11:05 pm

2 stops9h 50m

Des Moines

Mon 6/1

4:20 pm-9:55 pm

1 stop4h 35m

$380

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 5/15

6:00 am-10:37 am

1 stop5h 37m

Des Moines

Mon 5/18

5:00 am-12:17 pm

1 stop6h 17m

$391

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 6/6

6:50 am-2:20 pm

1 stop8h 30m

Des Moines

Tue 6/9

6:00 am-2:27 pm

2 stops7h 27m

$392

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 5/28

7:40 am-11:45 am

1 stop5h 05m

Des Moines

Sun 5/31

5:20 am-4:00 pm

1 stop9h 40m

$396

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 6/6

7:52 pm-12:12 am

1 stop5h 20m

Des Moines

Tue 6/9

1:37 pm-7:50 pm

1 stop5h 13m

$398

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 5/15

6:53 pm-11:24 pm

1 stop5h 31m

Des Moines

Mon 5/18

6:15 am-12:17 pm

1 stop5h 02m

$401

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 5/28

7:40 am-11:45 am

1 stop5h 05m

Des Moines

Sun 5/31

5:20 am-5:30 pm

2 stops11h 10m

$402

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 7/3

4:16 pm-11:24 pm

1 stop8h 08m

Des Moines

Tue 7/7

11:23 am-5:45 pm

1 stop5h 22m

$407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Charleston to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in May, then February is your next best option. Flight prices from Charleston to Des Moines during February average around $317.

How have Charleston to Des Moines flight prices changed over time?

When to book flights from Charleston to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Des Moines (CHS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Des Moines

Fastest flight time

5h 27m

Direct flights

None
The fastest flight from Charleston to Des Moines takes 5h 27m
There are no direct flights from Charleston to Des Moines. There are no popular flight routes from Charleston to Des Moines.
Search flight deals

  • How far is Charleston to Des Moines by plane?

    There are 966.2 mi between Charleston and Des Moines. 5h 27m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?

    Prices for flights from Charleston Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?

  • How old do you have to be to fly from Charleston Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Charleston to Des Moines?

Best airlines flying from Charleston to Des Moines

Compare and see reviews for airlines that fly from Charleston to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $233Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,314 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Des Moines?

Finding the right flight to Des Moines from Charleston is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Charleston to Des Moines with flexible booking policies on momondo?

Flights from Charleston to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charleston to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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