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Cheap flights from Charleston to Des Moines from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Des Moines departing on 6/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charleston to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:47 pm - 11:50 pm
CHS
-
DSM
5h 03m
1 stop
American Airlines Logo
5:00 am - 11:31 am
DSM
-
CHS
5h 31m
1 stop
$355American Airlines
Wed, May 27 - Tue, Jun 2
American Airlines Logo
7:19 pm - 11:57 pm
CHS
-
DSM
5h 38m
1 stop
American Airlines Logo
6:02 am - 2:41 pm
DSM
-
CHS
7h 39m
2 stops
$360American Airlines
Wed, May 27 - Tue, Jun 2
Multiple Airlines Logo
8:20 pm - 8:12 pm
CHS
-
DSM
24h 52m
1 stop
Multiple Airlines Logo
4:25 pm - 9:38 am
DSM
-
CHS
16h 13m
1 stop
$361Multiple Airlines
Thu, May 21 - Tue, May 26
Southwest Logo
2:10 pm - 10:45 pm
CHS
-
DSM
9h 35m
2 stops
Southwest Logo
5:20 am - 6:15 pm
DSM
-
CHS
11h 55m
2 stops
$371Southwest
Wed, Jul 1 - Wed, Jul 8
American Airlines Logo
7:19 pm - 11:57 pm
CHS
-
DSM
5h 38m
1 stop
American Airlines Logo
7:10 am - 5:39 pm
DSM
-
CHS
9h 29m
1 stop
$375American Airlines
Mon, Jun 1 - Mon, Jun 8
Southwest Logo
4:45 pm - 11:30 pm
CHS
-
DSM
7h 45m
2 stops
Southwest Logo
4:40 pm - 10:50 pm
DSM
-
CHS
5h 10m
1 stop
$380Southwest
Thu, Jun 4 - Mon, Jun 8
Southwest Logo
5:55 pm - 11:30 pm
CHS
-
DSM
6h 35m
1 stop
Southwest Logo
3:45 pm - 9:25 pm
DSM
-
CHS
4h 40m
1 stop
$381Southwest
Thu, Jun 11 - Tue, Jun 16
Delta Logo
6:03 pm - 10:32 pm
CHS
-
DSM
5h 29m
1 stop
Delta Logo
6:39 pm - 12:36 am
DSM
-
CHS
4h 57m
1 stop
$385Delta
Thu, Jun 4 - Tue, Jun 9
Southwest Logo
4:45 pm - 11:30 pm
CHS
-
DSM
7h 45m
2 stops
Southwest Logo
3:45 pm - 9:25 pm
DSM
-
CHS
4h 40m
1 stop
$386Southwest
Thu, Jun 11 - Tue, Jun 16
Southwest Logo
6:35 am - 1:45 pm
CHS
-
DSM
8h 10m
2 stops
Southwest Logo
5:30 am - 7:20 pm
DSM
-
CHS
12h 50m
2 stops
$391Southwest
Thu, Sep 10 - Sat, Sep 12

United Airlines flights from Charleston to Des Moines

Our best United Airlines deals on Charleston to Des Moines flight tickets
United Airlines
Aug 11
CHS3:25 pmCharleston
4h 59m
1 stop
DSM7:24 pmDes Moines
Aug 12
DSM3:24 pmDes Moines
5h 24m
1 stop
CHS9:48 pmCharleston
$415
United Airlines
Aug 11
CHS3:25 pmCharleston
4h 59m
1 stop
DSM7:24 pmDes Moines
Aug 12
DSM5:00 amDes Moines
8h 25m
2 stops
CHS2:25 pmCharleston
$420
United Airlines
Aug 11
CHS1:00 pmCharleston
11h 55m
2 stops
DSM11:55 pmDes Moines
Aug 12
DSM6:00 amDes Moines
7h 54m
2 stops
CHS2:54 pmCharleston
$425

American Airlines flights from Charleston to Des Moines

Our best American Airlines deals on Charleston to Des Moines flight tickets
American Airlines
May 27
CHS7:47 pmCharleston
5h 03m
1 stop
DSM11:50 pmDes Moines
Jun 2
DSM5:00 amDes Moines
5h 31m
1 stop
CHS11:31 amCharleston
$355
American Airlines
May 27
CHS7:19 pmCharleston
5h 38m
1 stop
DSM11:57 pmDes Moines
Jun 2
DSM6:02 amDes Moines
7h 39m
2 stops
CHS2:41 pmCharleston
$360
American Airlines
Jun 1
CHS7:19 pmCharleston
5h 38m
1 stop
DSM11:57 pmDes Moines
Jun 8
DSM7:10 amDes Moines
9h 29m
1 stop
CHS5:39 pmCharleston
$375

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/27

7:47 pm-11:50 pm

1 stop5h 03m

Des Moines

Tue 6/2

5:00 am-11:31 am

1 stop5h 31m

$355

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/27

7:19 pm-11:57 pm

1 stop5h 38m

Des Moines

Tue 6/2

6:02 am-2:41 pm

2 stops7h 39m

$360

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 5/21

8:20 pm-8:12 pm

1 stop24h 52m

Des Moines

Tue 5/26

4:25 pm-9:38 am

1 stop16h 13m

$361

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 7/1

2:10 pm-10:45 pm

2 stops9h 35m

Des Moines

Wed 7/8

5:20 am-6:15 pm

2 stops11h 55m

$371

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Mon 6/1

7:19 pm-11:57 pm

1 stop5h 38m

Des Moines

Mon 6/8

7:10 am-5:39 pm

1 stop9h 29m

$375

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 6/4

4:45 pm-11:30 pm

2 stops7h 45m

Des Moines

Mon 6/8

4:40 pm-10:50 pm

1 stop5h 10m

$380

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 6/11

5:55 pm-11:30 pm

1 stop6h 35m

Des Moines

Tue 6/16

3:45 pm-9:25 pm

1 stop4h 40m

$381
Quickest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 6/4

6:03 pm-10:32 pm

1 stop5h 29m

Des Moines

Tue 6/9

6:39 pm-12:36 am

1 stop4h 57m

$385

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 6/11

4:45 pm-11:30 pm

2 stops7h 45m

Des Moines

Tue 6/16

3:45 pm-9:25 pm

1 stop4h 40m

$386

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 9/10

6:35 am-1:45 pm

2 stops8h 10m

Des Moines

Sat 9/12

5:30 am-7:20 pm

2 stops12h 50m

$391

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Charleston to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in April, then February is your next best option. Flight prices from Charleston to Des Moines during February average around $317.

How have Charleston to Des Moines flight prices changed over time?

As of May 2026, prices for Charleston to Des Moines flights are approximately 66% cheaper when compared to flights at the same time last year.

When to book flights from Charleston to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Des Moines (CHS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Des Moines

Fastest flight time

5h 28m

Direct flights

None
The fastest flight from Charleston to Des Moines takes 5h 28m
There are no direct flights from Charleston to Des Moines. There are no popular flight routes from Charleston to Des Moines.
Search flight deals

Frequently asked questions about flying from Charleston to Des Moines

  • How far is Charleston to Des Moines by plane?

    There are 966.2 mi between Charleston and Des Moines. 5h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?

    Prices for flights from Charleston Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?

  • How old do you have to be to fly from Charleston Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Charleston to Des Moines?

Best airlines flying from Charleston to Des Moines

Compare and see reviews for airlines that fly from Charleston to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $233Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,456 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Des Moines?

Finding the right flight to Des Moines from Charleston is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Charleston to Des Moines with flexible booking policies on momondo?

Flights from Charleston to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charleston to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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