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Cheap flights from Charleston to Des Moines from $154

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:08 pm - 11:58 pmCHS  Charleston-DSM Des Moines
5h 50m1 stop Charlotte Douglas
American Airlines Logo
7:29 am - 3:02 pmDSM  Des Moines-CHS Charleston
6h 33m1 stop Chicago O'Hare Intl
$325American Airlines
Sat, Oct 10 - Sat, Oct 17
American Airlines Logo
6:40 am - 10:40 amCHS  Charleston-DSM Des Moines
5h 00m1 stop Charlotte Douglas
American Airlines Logo
2:26 pm - 10:09 pmDSM  Des Moines-CHS Charleston
6h 43m1 stop Washington, D.C. Reagan-National
$325American Airlines
Sat, Oct 24 - Mon, Oct 26
Delta Logo
7:02 am - 10:42 amCHS  Charleston-DSM Des Moines
4h 40m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:54 pm - 11:59 pmDSM  Des Moines-CHS Charleston
4h 05m1 stop Atlanta Hartsfield-Jackson
$325Delta
Sat, Oct 24 - Tue, Oct 27
Delta Logo
4:20 pm - 10:33 pmCHS  Charleston-DSM Des Moines
7h 13m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:54 pm - 11:59 pmDSM  Des Moines-CHS Charleston
4h 05m1 stop Atlanta Hartsfield-Jackson
$325Delta
Wed, Oct 21 - Wed, Oct 28
Multiple Airlines Logo
3:14 pm - 10:08 pmCHS  Charleston-DSM Des Moines
7h 54m1 stop Fort Myers SW Florida Intl
Multiple Airlines Logo
6:37 pm - 9:01 pmDSM  Des Moines-CHS Charleston
25h 24m1 stop Fort Lauderdale
$325Multiple Airlines
Fri, Oct 23 - Sun, Oct 25
American Airlines Logo
7:26 pm - 11:26 pmCHS  Charleston-DSM Des Moines
5h 00m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 10:26 pmDSM  Des Moines-CHS Charleston
5h 55m1 stop Dallas/Fort Worth
$325American Airlines
Mon, Nov 2 - Sat, Nov 7
Delta Logo
12:09 pm - 3:16 pmCHS  Charleston-DSM Des Moines
4h 07m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:07 pm - 11:59 pmDSM  Des Moines-CHS Charleston
6h 52m1 stop Atlanta Hartsfield-Jackson
$325Delta
Sat, Oct 10 - Sat, Oct 17
United Airlines Logo
2:52 pm - 9:55 pmCHS  Charleston-DSM Des Moines
8h 03m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
9:55 am - 6:06 pmDSM  Des Moines-CHS Charleston
7h 11m1 stop Chicago O'Hare Intl
$330United Airlines
Mon, Nov 2 - Sat, Nov 7
United Airlines Logo
6:30 am - 10:31 amCHS  Charleston-DSM Des Moines
5h 01m1 stop Chicago O'Hare Intl
United Airlines Logo
9:55 am - 7:11 pmDSM  Des Moines-CHS Charleston
8h 16m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$330United Airlines
Wed, Oct 21 - Wed, Oct 28
American Airlines Logo
5:05 am - 1:30 pmCHS  Charleston-DSM Des Moines
9h 25m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
7:29 am - 2:55 pmDSM  Des Moines-CHS Charleston
6h 26m1 stop Chicago O'Hare Intl
$376American Airlines
Sat, Oct 24 - Mon, Oct 26

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Delta flights from Charleston to Des Moines

Our best Delta deals on Charleston to Des Moines flight tickets
Delta
Oct 10
CHS12:09 pmCharleston
4h 07m
1 stop
DSM3:16 pmDes Moines
Oct 17
DSM4:07 pmDes Moines
6h 52m
1 stop
CHS11:59 pmCharleston
$325
Delta
Oct 24
CHS12:09 pmCharleston
4h 07m
1 stop
DSM3:16 pmDes Moines
Oct 25
DSM6:55 amDes Moines
6h 33m
1 stop
CHS2:28 pmCharleston
$371
Delta
Oct 16
CHS7:05 pmCharleston
4h 28m
1 stop
DSM10:33 pmDes Moines
Oct 23
DSM6:54 pmDes Moines
4h 05m
1 stop
CHS11:59 pmCharleston
$375

United Airlines flights from Charleston to Des Moines

Our best United Airlines deals on Charleston to Des Moines flight tickets
United Airlines
Oct 21
CHS6:30 amCharleston
5h 01m
1 stop
DSM10:31 amDes Moines
Oct 28
DSM9:55 amDes Moines
8h 16m
2 stops
CHS7:11 pmCharleston
$330
United Airlines
Oct 13
CHS6:50 pmCharleston
5h 45m
1 stop
DSM11:35 pmDes Moines
Oct 15
DSM1:24 pmDes Moines
7h 09m
1 stop
CHS9:33 pmCharleston
$416
United Airlines
Oct 28
CHS3:35 pmCharleston
7h 20m
1 stop
DSM9:55 pmDes Moines
Oct 31
DSM9:36 amDes Moines
7h 28m
1 stop
CHS6:04 pmCharleston
$425

momondo Fare Finder

 
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 10/10

7:08 pm-11:58 pm

1 stop5h 50m

Des Moines

Sat 10/17

7:29 am-3:02 pm

1 stop6h 33m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 10/24

6:40 am-10:40 am

1 stop5h 00m

Des Moines

Mon 10/26

2:26 pm-10:09 pm

1 stop6h 43m

$325
Quickest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 10/24

7:02 am-10:42 am

1 stop4h 40m

Des Moines

Tue 10/27

6:54 pm-11:59 pm

1 stop4h 05m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Wed 10/21

4:20 pm-10:33 pm

1 stop7h 13m

Des Moines

Wed 10/28

6:54 pm-11:59 pm

1 stop4h 05m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Fri 10/23

3:14 pm-10:08 pm

1 stop7h 54m

Des Moines

Sun 10/25

6:37 pm-9:01 pm

1 stop25h 24m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Mon 11/2

7:26 pm-11:26 pm

1 stop5h 00m

Des Moines

Sat 11/7

3:31 pm-10:26 pm

1 stop5h 55m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 10/10

12:09 pm-3:16 pm

1 stop4h 07m

Des Moines

Sat 10/17

4:07 pm-11:59 pm

1 stop6h 52m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Mon 11/2

2:52 pm-9:55 pm

2 stops8h 03m

Des Moines

Sat 11/7

9:55 am-6:06 pm

1 stop7h 11m

$330

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Wed 10/21

6:30 am-10:31 am

1 stop5h 01m

Des Moines

Wed 10/28

9:55 am-7:11 pm

2 stops8h 16m

$330

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 10/24

5:05 am-1:30 pm

2 stops9h 25m

Des Moines

Mon 10/26

7:29 am-2:55 pm

1 stop6h 26m

$376

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Charleston to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $382 to $458.
The lowest price recently found on this route was $325.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in April, then February is your next best option. Flight prices from Charleston to Des Moines during February average around $317.

How have Charleston to Des Moines flight prices changed over time?

As of September 2026, prices for Charleston to Des Moines flights are approximately 23% more expensive when compared to flights at the same time last year.

When to book flights from Charleston to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Des Moines (CHS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Des Moines

Best Price Found

$154

Fastest flight time

4h 47m

Direct flights

None
The best one-way flight to Des Moines from Charleston in the past 72 hours is $154. The best round-trip flight deal from Charleston to Des Moines found on momondo in the last 72 hours is $325.
The fastest flight from Charleston to Des Moines takes 4h 47m
There are no direct flights from Charleston to Des Moines. There are no popular flight routes from Charleston to Des Moines.
Search flight deals

Frequently asked questions about flying from Charleston to Des Moines

  • How far is Charleston to Des Moines by plane?

    There are 966.2 mi between Charleston and Des Moines. 4h 47m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?

    Prices for flights from Charleston Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?

  • How old do you have to be to fly from Charleston Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Charleston to Des Moines?

Best airlines flying from Charleston to Des Moines

Compare and see reviews for airlines that fly from Charleston to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $233Free CancellationRating
7.0
12,076 reviews
Search American Airlines flights
DeltaPriceFrom $326Free CancellationRating
7.8
8,591 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Newton
Boone
Johnston
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Des Moines?

Finding the right flight to Des Moines from Charleston is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Charleston to Des Moines with flexible booking policies on momondo?

Flights from Charleston to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charleston to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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