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Cheap flights from Charleston to Des Moines from $163

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:35 pm - 11:30 pmCHS  Charleston-DSM Des Moines
4h 55m1 stop Charlotte Douglas
American Airlines Logo
9:45 am - 6:33 pmDSM  Des Moines-CHS Charleston
7h 48m1 stop Dallas/Fort Worth
$325American Airlines
Mon, Dec 7 - Wed, Dec 9
American Airlines Logo
7:35 pm - 11:30 pmCHS  Charleston-DSM Des Moines
4h 55m1 stop Charlotte Douglas
American Airlines Logo
5:24 am - 1:03 pmDSM  Des Moines-CHS Charleston
6h 39m1 stop Washington, D.C. Reagan-National
$325American Airlines
Mon, Dec 7 - Thu, Dec 10
United Airlines Logo
5:00 pm - 9:25 pmCHS  Charleston-DSM Des Moines
5h 25m1 stop Chicago O'Hare Intl
United Airlines Logo
1:15 pm - 11:59 pmDSM  Des Moines-CHS Charleston
9h 44m2 stops Chicago O'Hare Intl Newark
$330United Airlines
Mon, Dec 7 - Wed, Dec 9
American Airlines Logo
12:18 pm - 7:01 pmCHS  Charleston-DSM Des Moines
7h 43m1 stop Chicago O'Hare Intl
American Airlines Logo
2:05 pm - 10:08 pmDSM  Des Moines-CHS Charleston
7h 03m1 stop Chicago O'Hare Intl
$362American Airlines
Tue, Dec 8 - Thu, Dec 10
American Airlines Logo
6:02 am - 1:35 pmCHS  Charleston-DSM Des Moines
8h 33m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
2:05 pm - 10:08 pmDSM  Des Moines-CHS Charleston
7h 03m1 stop Chicago O'Hare Intl
$402American Airlines
Tue, Dec 8 - Thu, Dec 10
United Airlines Logo
6:00 am - 12:39 pmCHS  Charleston-DSM Des Moines
7h 39m1 stop Chicago O'Hare Intl
United Airlines Logo
1:15 pm - 9:21 pmDSM  Des Moines-CHS Charleston
7h 06m1 stop Chicago O'Hare Intl
$425United Airlines
Sat, Dec 12 - Mon, Dec 14
United Airlines Logo
6:45 am - 2:26 pmCHS  Charleston-DSM Des Moines
8h 41m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
1:15 pm - 9:21 pmDSM  Des Moines-CHS Charleston
7h 06m1 stop Chicago O'Hare Intl
$430United Airlines
Sat, Dec 12 - Mon, Dec 14
Delta Logo
5:55 pm - 10:38 pmCHS  Charleston-DSM Des Moines
5h 43m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:45 am - 2:19 pmDSM  Des Moines-CHS Charleston
6h 34m1 stop Minneapolis St Paul
$791Delta
Thu, Dec 24 - Sun, Dec 27
Delta Logo
1:01 pm - 4:49 pmCHS  Charleston-DSM Des Moines
4h 48m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:41 am - 2:17 pmDSM  Des Moines-CHS Charleston
6h 36m1 stop Minneapolis St Paul
$929Delta
Fri, Dec 4 - Sun, Dec 6
Delta Logo
1:01 pm - 4:49 pmCHS  Charleston-DSM Des Moines
4h 48m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:41 am - 2:17 pmDSM  Des Moines-CHS Charleston
6h 36m1 stop Minneapolis St Paul
$939Delta
Fri, Dec 4 - Sun, Dec 6

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American Airlines flights from Charleston to Des Moines

Our best American Airlines deals on Charleston to Des Moines flight tickets
American Airlines
Dec 7
CHS7:35 pmCharleston
4h 55m
1 stop
DSM11:30 pmDes Moines
Dec 10
DSM5:24 amDes Moines
6h 39m
1 stop
CHS1:03 pmCharleston
$325
American Airlines
Dec 8
CHS12:18 pmCharleston
7h 43m
1 stop
DSM7:01 pmDes Moines
Dec 10
DSM2:05 pmDes Moines
7h 03m
1 stop
CHS10:08 pmCharleston
$362
American Airlines
Dec 8
CHS6:02 amCharleston
8h 33m
2 stops
DSM1:35 pmDes Moines
Dec 10
DSM2:05 pmDes Moines
7h 03m
1 stop
CHS10:08 pmCharleston
$402

United Airlines flights from Charleston to Des Moines

Our best United Airlines deals on Charleston to Des Moines flight tickets
United Airlines
Dec 7
CHS5:00 pmCharleston
5h 25m
1 stop
DSM9:25 pmDes Moines
Dec 9
DSM1:15 pmDes Moines
9h 44m
2 stops
CHS11:59 pmCharleston
$330
United Airlines
Dec 12
CHS6:00 amCharleston
7h 39m
1 stop
DSM12:39 pmDes Moines
Dec 14
DSM1:15 pmDes Moines
7h 06m
1 stop
CHS9:21 pmCharleston
$425
United Airlines
Dec 12
CHS6:45 amCharleston
8h 41m
2 stops
DSM2:26 pmDes Moines
Dec 14
DSM1:15 pmDes Moines
7h 06m
1 stop
CHS9:21 pmCharleston
$430

momondo Fare Finder

 
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Mon 12/7

7:35 pm-11:30 pm

1 stop4h 55m

Des Moines

Wed 12/9

9:45 am-6:33 pm

1 stop7h 48m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Mon 12/7

7:35 pm-11:30 pm

1 stop4h 55m

Des Moines

Thu 12/10

5:24 am-1:03 pm

1 stop6h 39m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Mon 12/7

5:00 pm-9:25 pm

1 stop5h 25m

Des Moines

Wed 12/9

1:15 pm-11:59 pm

2 stops9h 44m

$330

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 12/8

12:18 pm-7:01 pm

1 stop7h 43m

Des Moines

Thu 12/10

2:05 pm-10:08 pm

1 stop7h 03m

$362

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 12/8

6:02 am-1:35 pm

2 stops8h 33m

Des Moines

Thu 12/10

2:05 pm-10:08 pm

1 stop7h 03m

$402

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 12/12

6:00 am-12:39 pm

1 stop7h 39m

Des Moines

Mon 12/14

1:15 pm-9:21 pm

1 stop7h 06m

$425

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 12/12

6:45 am-2:26 pm

2 stops8h 41m

Des Moines

Mon 12/14

1:15 pm-9:21 pm

1 stop7h 06m

$430

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Thu 12/24

5:55 pm-10:38 pm

1 stop5h 43m

Des Moines

Sun 12/27

6:45 am-2:19 pm

1 stop6h 34m

$791
Quickest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Fri 12/4

1:01 pm-4:49 pm

1 stop4h 48m

Des Moines

Sun 12/6

6:41 am-2:17 pm

1 stop6h 36m

$929

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Fri 12/4

1:01 pm-4:49 pm

1 stop4h 48m

Des Moines

Sun 12/6

6:41 am-2:17 pm

1 stop6h 36m

$939

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Charleston to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in April, then February is your next best option. Flight prices from Charleston to Des Moines during February average around $317.

How have Charleston to Des Moines flight prices changed over time?

As of November 2026, prices for Charleston to Des Moines flights are approximately 41% more expensive when compared to flights at the same time last year.

When to book flights from Charleston to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Des Moines (CHS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Des Moines

Best Price Found

$163

Fastest flight time

7h 26m

Direct flights

None
The best one-way flight to Des Moines from Charleston in the past 72 hours is $163. The best round-trip flight deal from Charleston to Des Moines found on momondo in the last 72 hours is $325.
The fastest flight from Charleston to Des Moines takes 7h 26m
There are no direct flights from Charleston to Des Moines. There are no popular flight routes from Charleston to Des Moines.
Search flight deals

Frequently asked questions about flying from Charleston to Des Moines

  • How far is Charleston to Des Moines by plane?

    There are 966.2 mi between Charleston and Des Moines. 7h 26m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?

    Prices for flights from Charleston Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?

  • How old do you have to be to fly from Charleston Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Charleston to Des Moines?

Best airlines flying from Charleston to Des Moines

Compare and see reviews for airlines that fly from Charleston to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $233Free CancellationRating
7.0
12,228 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.8
8,698 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Johnston
Boone
Newton
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Des Moines?

Finding the right flight to Des Moines from Charleston is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Charleston to Des Moines with flexible booking policies on momondo?

Flights from Charleston to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charleston to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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