What is the cheapest airline that flies from Charleston to Des Moines?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Charleston to Des Moines

When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?

Prices for flights from Charleston Airport to Des Moines Airport were last updated today.

How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?

The number of operators available for flights from Charleston Airport to Des Moines Airport is 2 as of September 2025.

How old do you have to be to fly from Charleston Airport to Des Moines Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$158 Cheap Flights from Charleston to Des Moines in 2025/26

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Find the cheapest flights from Charleston to Des Moines

Round-trip

One-way

Last minute

Cheap round-trip flights

5:08 pm - 2:50 pmCHS-DSM

22h 42m1 stop

8:30 am - 8:15 pmDSM-CHS

10h 45m1 stop

$195Multiple Airlines

Find Deal

Thu, Oct 30 - Mon, Nov 3

10:11 am - 10:04 amCHS-DSM

24h 53m2 stops

8:30 am - 6:13 pmDSM-CHS

8h 43m1 stop

$226Multiple Airlines

Find Deal

Thu, Oct 30 - Mon, Nov 3

6:36 pm - 10:28 pmCHS-DSM

4h 52m1 stop

3:56 pm - 9:48 pmDSM-CHS

4h 52m1 stop

$315American Airlines

Find Deal

Thu, Oct 16 - Wed, Oct 22

6:15 am - 11:00 amCHS-DSM

5h 45m2 stops

6:20 am - 4:25 pmDSM-CHS

9h 05m2 stops

$325Southwest

Find Deal

Thu, Oct 16 - Wed, Oct 22

4:14 pm - 10:30 pmCHS-DSM

7h 16m1 stop

7:20 am - 5:02 pmDSM-CHS

8h 42m1 stop

$343Delta

Find Deal

Fri, Oct 31 - Mon, Nov 3

8:25 am - 7:55 pmCHS-DSM

12h 30m2 stops

6:15 am - 5:05 pmDSM-CHS

9h 50m2 stops

$345Southwest

Find Deal

Wed, Dec 10 - Thu, Dec 25

11:31 am - 5:24 pmCHS-DSM

6h 53m1 stop

11:31 am - 11:44 pmDSM-CHS

11h 13m2 stops

$365United Airlines

Find Deal

Thu, Oct 16 - Wed, Oct 22

6:44 pm - 11:48 pmCHS-DSM

6h 04m1 stop

2:07 pm - 7:32 pmDSM-CHS

4h 25m1 stop

$367American Airlines

Find Deal

Wed, Dec 10 - Thu, Dec 25

2:30 pm - 5:46 pmCHS-DSM

4h 16m1 stop

7:46 am - 5:18 pmDSM-CHS

8h 32m1 stop

$387Delta

Find Deal

Fri, Nov 21 - Mon, Nov 24

4:38 pm - 9:37 pmCHS-DSM

5h 59m1 stop

8:00 am - 1:55 pmDSM-CHS

4h 55m1 stop

$421United Airlines

Find Deal

Thu, Dec 11 - Sun, Dec 14

Delta flights from Charleston to Des Moines

Our best Delta deals on Charleston to Des Moines flight tickets

Delta

Oct 31

CHS4:14 pmCharleston

7h 16m

1 stop

DSM10:30 pmDes Moines

Nov 3

DSM7:20 amDes Moines

8h 42m

1 stop

CHS5:02 pmCharleston

$343

Find similar

Delta

Nov 21

CHS2:30 pmCharleston

4h 16m

1 stop

DSM5:46 pmDes Moines

Nov 24

DSM7:46 amDes Moines

8h 32m

1 stop

CHS5:18 pmCharleston

$387

Find similar

Delta

Nov 22

CHS7:05 amCharleston

7h 27m

1 stop

DSM1:32 pmDes Moines

Nov 30

DSM2:20 pmDes Moines

25h 58m

1 stop

CHS5:18 pmCharleston

$455

Find similar

Southwest flights from Charleston to Des Moines

Our best Southwest deals on Charleston to Des Moines flight tickets

Southwest

Oct 16

CHS6:15 amCharleston

5h 45m

2 stops

DSM11:00 amDes Moines

Oct 22

DSM6:20 amDes Moines

9h 05m

2 stops

CHS4:25 pmCharleston

$325

Find similar

Southwest

Dec 10

CHS8:25 amCharleston

12h 30m

2 stops

DSM7:55 pmDes Moines

Dec 25

DSM6:15 amDes Moines

9h 50m

2 stops

CHS5:05 pmCharleston

$345

Find similar

Southwest

Oct 29

CHS11:25 amCharleston

10h 30m

2 stops

DSM8:55 pmDes Moines

Nov 3

DSM6:15 amDes Moines

9h 50m

2 stops

CHS5:05 pmCharleston

$381

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 10/30

5:08 pm-2:50 pm

1 stop22h 42m

Des Moines

Mon 11/3

8:30 am-8:15 pm

1 stop10h 45m

$195

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 10/30

10:11 am-10:04 am

2 stops24h 53m

Des Moines

Mon 11/3

8:30 am-6:13 pm

1 stop8h 43m

$226

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 10/16

6:36 pm-10:28 pm

1 stop4h 52m

Des Moines

Wed 10/22

3:56 pm-9:48 pm

1 stop4h 52m

$315

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 10/16

6:15 am-11:00 am

2 stops5h 45m

Des Moines

Wed 10/22

6:20 am-4:25 pm

2 stops9h 05m

$325

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 10/31

4:14 pm-10:30 pm

1 stop7h 16m

Des Moines

Mon 11/3

7:20 am-5:02 pm

1 stop8h 42m

$343

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 12/10

8:25 am-7:55 pm

2 stops12h 30m

Des Moines

Thu 12/25

6:15 am-5:05 pm

2 stops9h 50m

$345

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 10/16

11:31 am-5:24 pm

1 stop6h 53m

Des Moines

Wed 10/22

11:31 am-11:44 pm

2 stops11h 13m

$365

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 12/10

6:44 pm-11:48 pm

1 stop6h 04m

Des Moines

Thu 12/25

2:07 pm-7:32 pm

1 stop4h 25m

$367

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 11/21

2:30 pm-5:46 pm

1 stop4h 16m

Des Moines

Mon 11/24

7:46 am-5:18 pm

1 stop8h 32m

$387

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/11

4:38 pm-9:37 pm

1 stop5h 59m

Des Moines

Sun 12/14

8:00 am-1:55 pm

1 stop4h 55m

$421

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then May is your next best option. Flight prices from Charleston to Des Moines during May average around $307.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Charleston to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $321. Flights from Charleston to Des Moines on a Saturday will generally be more expensive and average around $594. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Charleston to Des Moines in the afternoon for as low as $411. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $485. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Charleston to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Charleston to Des Moines (CHS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Des Moines

Direct flights	None

There are no direct flights from Charleston to Des Moines. There are no popular flight routes from Charleston to Des Moines.

Search flight deals

How far is Charleston to Des Moines by plane?
There are 966.2 mi between Charleston and Des Moines. 4h 16m is a normal flight duration for this route.
When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?
Prices for flights from Charleston Airport to Des Moines Airport were last updated today.
How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?
The number of operators available for flights from Charleston Airport to Des Moines Airport is 2 as of September 2025.
How old do you have to be to fly from Charleston Airport to Des Moines Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Charleston to Des Moines?
Based on momondo bookings for flights between Charleston and Des Moines, the leading airline is Delta, making up 55% of the total bookings. Other popular airlines include American Airlines with 45%.

Best airlines flying from Charleston to Des Moines

Compare and see reviews for airlines that fly from Charleston to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $236	Free Cancellation	Rating 7.9 7,973 reviews		Search Delta flights
American Airlines	PriceFrom $262	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

West Des Moines

Ames

Ankeny

Altoona

Clive

Urbandale

Pella

Newton

Osceola

Johnston

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Des Moines?

Finding the right flight to Des Moines from Charleston is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Charleston to Des Moines with flexible booking policies on momondo?

Flights from Charleston to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charleston to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.