What is the cheapest airline that flies from Charleston to Des Moines?

American Airlines and United Airlines are the most popular carriers operating from Charleston to Des Moines

When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?

Prices for flights from Charleston Airport to Des Moines Airport were last updated today.

How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?

The number of operators available for flights from Charleston Airport to Des Moines Airport is 2 as of December 2025.

How old do you have to be to fly from Charleston Airport to Des Moines Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$187 Cheap Flights from Charleston to Des Moines in 2025/26

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Find the cheapest flights from Charleston to Des Moines

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Cheap round-trip flights

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4:41 pm - 9:50 pm

CHS

DSM

6h 09m1 stop

8:00 am - 2:02 pm

DSM

CHS

5h 02m1 stop

$294United Airlines

Thu, Jan 15 - Tue, Jan 20

6:00 am - 2:33 pm

CHS

DSM

9h 33m2 stops

8:10 am - 4:17 pm

DSM

CHS

7h 07m1 stop

$299United Airlines

Thu, Jan 15 - Tue, Jan 20

6:00 am - 2:33 pm

CHS

DSM

9h 33m2 stops

8:00 am - 5:59 pm

DSM

CHS

8h 59m2 stops

$304United Airlines

Thu, Jan 15 - Tue, Jan 20

6:30 am - 10:38 am

CHS

DSM

5h 08m1 stop

5:16 pm - 11:55 pm

DSM

CHS

5h 39m1 stop

$317Delta

Wed, Jan 14 - Wed, Jan 21

1:45 pm - 7:20 pm

CHS

DSM

6h 35m1 stop

6:10 am - 12:50 pm

DSM

CHS

5h 40m2 stops

$322Southwest

Wed, Jan 14 - Wed, Jan 21

9:05 am - 7:20 pm

CHS

DSM

11h 15m2 stops

6:10 am - 12:50 pm

DSM

CHS

5h 40m2 stops

$327Southwest

Wed, Jan 14 - Wed, Jan 21

6:30 am - 10:41 am

CHS

DSM

5h 11m1 stop

9:45 am - 6:19 pm

DSM

CHS

7h 34m1 stop

$364Delta

Thu, Jan 22 - Sun, Jan 25

12:37 pm - 4:24 pm

CHS

DSM

4h 47m1 stop

7:00 am - 4:56 pm

DSM

CHS

8h 56m2 stops

$369American Airlines

Thu, Jan 22 - Sun, Jan 25

2:37 pm - 10:11 pm

CHS

DSM

8h 34m2 stops

7:00 am - 4:56 pm

DSM

CHS

8h 56m2 stops

$374American Airlines

Thu, Jan 22 - Sun, Jan 25

7:00 am - 11:30 am

CHS

DSM

5h 30m1 stop

3:45 pm - 9:25 pm

DSM

CHS

4h 40m1 stop

$387Southwest

Wed, Jun 10 - Wed, Jun 24

American Airlines flights from Charleston to Des Moines

Our best American Airlines deals on Charleston to Des Moines flight tickets

American Airlines

Jan 22

CHS12:37 pmCharleston

4h 47m

1 stop

DSM4:24 pmDes Moines

Jan 25

DSM7:00 amDes Moines

8h 56m

2 stops

CHS4:56 pmCharleston

$369

Find similar

American Airlines

Jan 22

CHS2:37 pmCharleston

8h 34m

2 stops

DSM10:11 pmDes Moines

Jan 25

DSM7:00 amDes Moines

8h 56m

2 stops

CHS4:56 pmCharleston

$374

Find similar

American Airlines

Dec 26

CHS8:08 pmCharleston

5h 29m

1 stop

DSM12:37 amDes Moines

Dec 30

DSM3:27 pmDes Moines

7h 38m

2 stops

CHS12:05 amCharleston

$498

Find similar

United Airlines flights from Charleston to Des Moines

Our best United Airlines deals on Charleston to Des Moines flight tickets

United Airlines

Jan 15

CHS4:41 pmCharleston

6h 09m

1 stop

DSM9:50 pmDes Moines

Jan 20

DSM8:00 amDes Moines

5h 02m

1 stop

CHS2:02 pmCharleston

$294

Find similar

United Airlines

Jan 15

CHS6:00 amCharleston

9h 33m

2 stops

DSM2:33 pmDes Moines

Jan 20

DSM8:10 amDes Moines

7h 07m

1 stop

CHS4:17 pmCharleston

$299

Find similar

United Airlines

Jan 15

CHS6:00 amCharleston

9h 33m

2 stops

DSM2:33 pmDes Moines

Jan 20

DSM8:00 amDes Moines

8h 59m

2 stops

CHS5:59 pmCharleston

$304

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 1/15

4:41 pm-9:50 pm

1 stop6h 09m

Des Moines

Tue 1/20

8:00 am-2:02 pm

1 stop5h 02m

$294

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 1/15

6:00 am-2:33 pm

2 stops9h 33m

Des Moines

Tue 1/20

8:10 am-4:17 pm

1 stop7h 07m

$299

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 1/15

6:00 am-2:33 pm

2 stops9h 33m

Des Moines

Tue 1/20

8:00 am-5:59 pm

2 stops8h 59m

$304

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 1/14

6:30 am-10:38 am

1 stop5h 08m

Des Moines

Wed 1/21

5:16 pm-11:55 pm

1 stop5h 39m

$317

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 1/14

1:45 pm-7:20 pm

1 stop6h 35m

Des Moines

Wed 1/21

6:10 am-12:50 pm

2 stops5h 40m

$322

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 1/14

9:05 am-7:20 pm

2 stops11h 15m

Des Moines

Wed 1/21

6:10 am-12:50 pm

2 stops5h 40m

$327

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 1/22

6:30 am-10:41 am

1 stop5h 11m

Des Moines

Sun 1/25

9:45 am-6:19 pm

1 stop7h 34m

$364

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 1/22

12:37 pm-4:24 pm

1 stop4h 47m

Des Moines

Sun 1/25

7:00 am-4:56 pm

2 stops8h 56m

$369

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 1/22

2:37 pm-10:11 pm

2 stops8h 34m

Des Moines

Sun 1/25

7:00 am-4:56 pm

2 stops8h 56m

$374

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 6/10

7:00 am-11:30 am

1 stop5h 30m

Des Moines

Wed 6/24

3:45 pm-9:25 pm

1 stop4h 40m

$387

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then May is your next best option. Flight prices from Charleston to Des Moines during May average around $307.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Charleston to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $321. Flights from Charleston to Des Moines on a Saturday will generally be more expensive and average around $594. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Charleston to Des Moines in the afternoon for as low as $411. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $485. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Charleston to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Charleston to Des Moines (CHS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Des Moines

Fastest flight time	5h 51m
Direct flights	None

The fastest flight from Charleston to Des Moines takes 5h 51m

There are no direct flights from Charleston to Des Moines. There are no popular flight routes from Charleston to Des Moines.

Search flight deals

How far is Charleston to Des Moines by plane?
There are 966.2 mi between Charleston and Des Moines. 5h 51m is a normal flight duration for this route.
When did momondo last update prices for flights from Charleston Airport to Des Moines Airport?
Prices for flights from Charleston Airport to Des Moines Airport were last updated today.
How many operators does momondo search for flights from Charleston Airport to Des Moines Airport?
The number of operators available for flights from Charleston Airport to Des Moines Airport is 2 as of December 2025.
How old do you have to be to fly from Charleston Airport to Des Moines Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Charleston to Des Moines?
Based on momondo bookings for flights between Charleston and Des Moines, the leading airline is Delta, making up 59% of the total bookings. Other popular airlines include American Airlines with 41%.

Best airlines flying from Charleston to Des Moines

Compare and see reviews for airlines that fly from Charleston to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $233	Free Cancellation	Rating 7.2 11,050 reviews		Search American Airlines flights
Delta	PriceFrom $236	Free Cancellation	Rating 7.9 8,007 reviews		Search Delta flights

West Des Moines

Ames

Ankeny

Altoona

Urbandale

Clive

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Des Moines?

Finding the right flight to Des Moines from Charleston is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Charleston to Des Moines with flexible booking policies on momondo?

Flights from Charleston to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Charleston to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.