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Cheap flights from Central America to Florence from $363

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Central America to Florence departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap one-way flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:05 pm - 11:58 pm
PTY
-
FLO
31h 53m2 stops
$363American Airlines
Thu, Mar 5
American Airlines Logo
2:50 pm - 5:23 pm
PTY
-
FLO
26h 33m2 stops
$368American Airlines
Tue, Mar 3
American Airlines Logo
3:13 pm - 5:21 pm
PTY
-
FLO
49h 08m2 stops
$396American Airlines
Sun, Mar 8
American Airlines Logo
2:39 pm - 11:12 pm
PTY
-
FLO
32h 33m2 stops
$407American Airlines
Mon, Mar 2
American Airlines Logo
2:39 pm - 5:45 pm
PTY
-
FLO
27h 06m2 stops
$423American Airlines
Fri, Mar 6
American Airlines Logo
2:50 pm - 4:46 pm
PTY
-
FLO
49h 56m2 stops
$489American Airlines
Sat, Mar 7

momondo Fare Finder

 
Customize your flight search to find flights from Central America to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Central America to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Thu 3/5

4:05 pm-11:58 pm

2 stops31h 53m

$363

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Tue 3/3

2:50 pm-5:23 pm

2 stops26h 33m

$368

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sun 3/8

3:13 pm-5:21 pm

2 stops49h 08m

$396

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Mon 3/2

2:39 pm-11:12 pm

2 stops32h 33m

$407

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Fri 3/6

2:39 pm-5:45 pm

2 stops27h 06m

$423

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sat 3/7

2:50 pm-4:46 pm

2 stops49h 56m

$489

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Central America to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Central America to Florence?

American Airlines is the most popular carrier operating from Central America to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Spirit Airlines and United Airlines are the top three most popular airlines that fly to Florence, South Carolina from Central America according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 4 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Central America to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Central America to Florence, South Carolina

Fastest flight time

19h 16m

Direct flights

None
The fastest flight from Central America to Florence, South Carolina takes 19h 16m
There are no direct flights from Central America to Florence, South Carolina. There are no popular flight routes from Central America to Florence, South Carolina.
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  • When did momondo last update prices for flights from Central America to Florence Airport?

    Prices for flights from Central America to Florence Airport were last updated today.

  • How old do you have to be to fly from Central America to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Central America to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Central America to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Central America to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Central America to Florence with flexible booking policies on momondo?

All flight searches from Central America to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Central America to Florence?

momondo helps you find the best flight between Central America and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Central America to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Central America to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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