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Cheap flights from Syracuse to Des Moines from $259

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Des Moines departing on 10/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Syracuse to Des Moines

Cheap round-trip flights

Delta Logo
6:00 am - 9:20 amSYR-DSM
4h 20m1 stop
Delta Logo
5:32 pm - 11:24 pmDSM-SYR
4h 52m1 stop
$259Delta
Find Deal
Thu, Oct 23 - Wed, Oct 29
American Airlines Logo
5:37 pm - 11:59 pmSYR-DSM
7h 22m1 stop
American Airlines Logo
6:22 pm - 12:20 amDSM-SYR
4h 58m1 stop
$274American Airlines
Find Deal
Fri, Oct 24 - Sun, Oct 26
United Airlines Logo
5:43 pm - 9:50 pmSYR-DSM
5h 07m1 stop
United Airlines Logo
3:25 pm - 9:28 pmDSM-SYR
5h 03m1 stop
$289United Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
United Airlines Logo
6:10 am - 12:19 pmSYR-DSM
7h 09m2 stops
United Airlines Logo
11:31 am - 4:47 pmDSM-SYR
4h 16m1 stop
$294United Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
United Airlines Logo
6:15 am - 10:32 amSYR-DSM
5h 17m1 stop
United Airlines Logo
11:31 am - 4:47 pmDSM-SYR
4h 16m1 stop
$329United Airlines
Find Deal
Fri, Sep 26 - Tue, Sep 30
United Airlines Logo
6:15 am - 10:32 amSYR-DSM
5h 17m1 stop
United Airlines Logo
3:15 pm - 11:13 pmDSM-SYR
6h 58m2 stops
$335United Airlines
Find Deal
Fri, Oct 24 - Mon, Oct 27
United Airlines Logo
6:00 am - 2:23 pmSYR-DSM
9h 23m2 stops
United Airlines Logo
1:00 pm - 9:28 pmDSM-SYR
7h 28m1 stop
$364United Airlines
Find Deal
Thu, Sep 25 - Sun, Sep 28
United Airlines Logo
6:10 am - 12:19 pmSYR-DSM
7h 09m2 stops
United Airlines Logo
9:20 am - 9:28 pmDSM-SYR
11h 08m2 stops
$366United Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
7:40 am - 2:21 pmSYR-DSM
7h 41m1 stop
American Airlines Logo
5:45 am - 11:43 amDSM-SYR
4h 58m1 stop
$377American Airlines
Find Deal
Tue, Oct 28 - Sun, Nov 2
Delta Logo
6:00 am - 9:20 amSYR-DSM
4h 20m1 stop
Delta Logo
5:56 pm - 11:04 pmDSM-SYR
4h 08m1 stop
$479Delta
Find Deal
Thu, Oct 9 - Tue, Oct 14

Delta flights from Syracuse to Des Moines

Our best Delta deals on Syracuse to Des Moines flight tickets
Delta
Oct 23
SYR6:00 amSyracuse Hancock Intl
4h 20m
1 stop
DSM9:20 amDes Moines
Oct 29
DSM5:32 pmDes Moines
4h 52m
1 stop
SYR11:24 pmSyracuse Hancock Intl
$259
Find similar
Delta
Oct 9
SYR6:00 amSyracuse Hancock Intl
4h 20m
1 stop
DSM9:20 amDes Moines
Oct 14
DSM5:56 pmDes Moines
4h 08m
1 stop
SYR11:04 pmSyracuse Hancock Intl
$479
Find similar
Delta
Oct 10
SYR6:00 amSyracuse Hancock Intl
4h 20m
1 stop
DSM9:20 amDes Moines
Oct 14
DSM5:56 pmDes Moines
4h 08m
1 stop
SYR11:04 pmSyracuse Hancock Intl
$559
Find similar

United Airlines flights from Syracuse to Des Moines

Our best United Airlines deals on Syracuse to Des Moines flight tickets
United Airlines
Sep 30
SYR5:43 pmSyracuse Hancock Intl
5h 07m
1 stop
DSM9:50 pmDes Moines
Oct 4
DSM3:25 pmDes Moines
5h 03m
1 stop
SYR9:28 pmSyracuse Hancock Intl
$289
Find similar
United Airlines
Sep 30
SYR6:10 amSyracuse Hancock Intl
7h 09m
2 stops
DSM12:19 pmDes Moines
Oct 4
DSM11:31 amDes Moines
4h 16m
1 stop
SYR4:47 pmSyracuse Hancock Intl
$294
Find similar
United Airlines
Sep 26
SYR6:15 amSyracuse Hancock Intl
5h 17m
1 stop
DSM10:32 amDes Moines
Sep 30
DSM11:31 amDes Moines
4h 16m
1 stop
SYR4:47 pmSyracuse Hancock Intl
$329
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 10/23

6:00 am-9:20 am

1 stop4h 20m

Des Moines

Wed 10/29

5:32 pm-11:24 pm

1 stop4h 52m

$259

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 10/24

5:37 pm-11:59 pm

1 stop7h 22m

Des Moines

Sun 10/26

6:22 pm-12:20 am

1 stop4h 58m

$274

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 9/30

5:43 pm-9:50 pm

1 stop5h 07m

Des Moines

Sat 10/4

3:25 pm-9:28 pm

1 stop5h 03m

$289

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 9/30

6:10 am-12:19 pm

2 stops7h 09m

Des Moines

Sat 10/4

11:31 am-4:47 pm

1 stop4h 16m

$294

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 9/26

6:15 am-10:32 am

1 stop5h 17m

Des Moines

Tue 9/30

11:31 am-4:47 pm

1 stop4h 16m

$329

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 10/24

6:15 am-10:32 am

1 stop5h 17m

Des Moines

Mon 10/27

3:15 pm-11:13 pm

2 stops6h 58m

$335

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 9/25

6:00 am-2:23 pm

2 stops9h 23m

Des Moines

Sun 9/28

1:00 pm-9:28 pm

1 stop7h 28m

$364

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 9/30

6:10 am-12:19 pm

2 stops7h 09m

Des Moines

Sat 10/4

9:20 am-9:28 pm

2 stops11h 08m

$366

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 10/28

7:40 am-2:21 pm

1 stop7h 41m

Des Moines

Sun 11/2

5:45 am-11:43 am

1 stop4h 58m

$377

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 10/9

6:00 am-9:20 am

1 stop4h 20m

Des Moines

Tue 10/14

5:56 pm-11:04 pm

1 stop4h 08m

$479

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Syracuse to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then April is your next best option. Flight prices from Syracuse to Des Moines during April average around $298.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Syracuse to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $337. Flights from Syracuse to Des Moines on a Monday will generally be more expensive and average around $602. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Syracuse to Des Moines in the afternoon for as low as $366. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $445. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Syracuse to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Des Moines (SYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Des Moines

Direct flights

None
There are no direct flights from Syracuse to Des Moines. There are no popular flight routes from Syracuse to Des Moines.
Search flight deals

  • How far is Syracuse Hancock Intl to Des Moines by plane?

    Syracuse Hancock Intl and Des Moines are 896.5 mi apart from one another. Flights usually cover this in 4h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Des Moines?

Best airlines flying from Syracuse to Des Moines

Compare and see reviews for airlines that fly from Syracuse to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
7,954 reviews
Search Delta flights
United AirlinesPriceFrom $300Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Des Moines?

It is quick and easy to find Syracuse to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Syracuse to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Des Moines?

Once you have performed a search for Syracuse to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Syracuse are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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