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Cheap flights from Syracuse to Des Moines from $176

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Des Moines departing on 12/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Syracuse to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:31 am - 2:19 pmSYR-DSM
4h 48m1 stop
United Airlines Logo
1:05 pm - 9:02 pmDSM-SYR
6h 57m1 stop
$309United Airlines
Find Deal
Wed, Nov 12 - Sun, Nov 16
United Airlines Logo
6:00 am - 2:19 pmSYR-DSM
9h 19m2 stops
United Airlines Logo
1:05 pm - 9:02 pmDSM-SYR
6h 57m1 stop
$314United Airlines
Find Deal
Wed, Nov 12 - Sun, Nov 16
United Airlines Logo
6:15 am - 4:12 pmSYR-DSM
10h 57m2 stops
United Airlines Logo
5:45 am - 4:40 pmDSM-SYR
9h 55m2 stops
$389United Airlines
Find Deal
Fri, Nov 14 - Tue, Nov 18
United Airlines Logo
6:30 am - 10:20 amSYR-DSM
4h 50m1 stop
United Airlines Logo
6:45 pm - 10:02 amDSM-SYR
14h 17m1 stop
$452United Airlines
Find Deal
Mon, Apr 6 - Fri, Apr 10
American Airlines Logo
2:41 pm - 10:02 pmSYR-DSM
8h 21m2 stops
American Airlines Logo
5:33 am - 2:16 pmDSM-SYR
7h 43m2 stops
$538American Airlines
Find Deal
Wed, Nov 12 - Sun, Nov 16
American Airlines Logo
6:03 am - 1:29 pmSYR-DSM
8h 26m1 stop
American Airlines Logo
8:51 am - 11:18 pmDSM-SYR
13h 27m1 stop
$966American Airlines
Find Deal
Sat, Nov 22 - Sat, Nov 29
American Airlines Logo
5:47 pm - 8:21 amSYR-DSM
15h 34m1 stop
American Airlines Logo
1:06 pm - 11:18 pmDSM-SYR
9h 12m1 stop
$985American Airlines
Find Deal
Sat, Nov 22 - Sat, Nov 29
American Airlines Logo
1:42 pm - 11:41 pmSYR-DSM
10h 59m2 stops
American Airlines Logo
1:06 pm - 11:18 pmDSM-SYR
9h 12m1 stop
$1,060American Airlines
Find Deal
Sat, Nov 22 - Sat, Nov 29
Delta Logo
7:05 am - 5:00 pmSYR-DSM
10h 55m2 stops
Delta Logo
6:17 am - 3:21 pmDSM-SYR
8h 04m2 stops
$2,236Delta
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Sat, Nov 22 - Sat, Nov 29
Delta Logo
6:00 am - 2:08 pmSYR-DSM
9h 08m2 stops
Delta Logo
6:17 am - 4:52 pmDSM-SYR
9h 35m2 stops
$2,454Delta
Find Deal
Sat, Nov 22 - Sat, Nov 29

United Airlines flights from Syracuse to Des Moines

Our best United Airlines deals on Syracuse to Des Moines flight tickets
United Airlines
Nov 12
SYR10:31 amSyracuse Hancock Intl
4h 48m
1 stop
DSM2:19 pmDes Moines
Nov 16
DSM1:05 pmDes Moines
6h 57m
1 stop
SYR9:02 pmSyracuse Hancock Intl
$309
Find similar
United Airlines
Nov 12
SYR6:00 amSyracuse Hancock Intl
9h 19m
2 stops
DSM2:19 pmDes Moines
Nov 16
DSM1:05 pmDes Moines
6h 57m
1 stop
SYR9:02 pmSyracuse Hancock Intl
$314
Find similar
United Airlines
Nov 14
SYR6:15 amSyracuse Hancock Intl
10h 57m
2 stops
DSM4:12 pmDes Moines
Nov 18
DSM5:45 amDes Moines
9h 55m
2 stops
SYR4:40 pmSyracuse Hancock Intl
$389
Find similar

American Airlines flights from Syracuse to Des Moines

Our best American Airlines deals on Syracuse to Des Moines flight tickets
American Airlines
Nov 12
SYR2:41 pmSyracuse Hancock Intl
8h 21m
2 stops
DSM10:02 pmDes Moines
Nov 16
DSM5:33 amDes Moines
7h 43m
2 stops
SYR2:16 pmSyracuse Hancock Intl
$538
Find similar
American Airlines
Nov 3
SYR7:08 amSyracuse Hancock Intl
8h 23m
1 stop
DSM2:31 pmDes Moines
Nov 5
DSM5:42 amDes Moines
4h 27m
1 stop
SYR11:09 amSyracuse Hancock Intl
$768
Find similar
American Airlines
Nov 22
SYR6:03 amSyracuse Hancock Intl
8h 26m
1 stop
DSM1:29 pmDes Moines
Nov 29
DSM8:51 amDes Moines
13h 27m
1 stop
SYR11:18 pmSyracuse Hancock Intl
$966
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Wed 11/12

10:31 am-2:19 pm

1 stop4h 48m

Des Moines

Sun 11/16

1:05 pm-9:02 pm

1 stop6h 57m

$309

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Wed 11/12

6:00 am-2:19 pm

2 stops9h 19m

Des Moines

Sun 11/16

1:05 pm-9:02 pm

1 stop6h 57m

$314

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 11/14

6:15 am-4:12 pm

2 stops10h 57m

Des Moines

Tue 11/18

5:45 am-4:40 pm

2 stops9h 55m

$389

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Mon 4/6

6:30 am-10:20 am

1 stop4h 50m

Des Moines

Fri 4/10

6:45 pm-10:02 am

1 stop14h 17m

$452

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Wed 11/12

2:41 pm-10:02 pm

2 stops8h 21m

Des Moines

Sun 11/16

5:33 am-2:16 pm

2 stops7h 43m

$538

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

6:03 am-1:29 pm

1 stop8h 26m

Des Moines

Sat 11/29

8:51 am-11:18 pm

1 stop13h 27m

$966

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

5:47 pm-8:21 am

1 stop15h 34m

Des Moines

Sat 11/29

1:06 pm-11:18 pm

1 stop9h 12m

$985

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

1:42 pm-11:41 pm

2 stops10h 59m

Des Moines

Sat 11/29

1:06 pm-11:18 pm

1 stop9h 12m

$1,060

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

7:05 am-5:00 pm

2 stops10h 55m

Des Moines

Sat 11/29

6:17 am-3:21 pm

2 stops8h 04m

$2,236

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

6:00 am-2:08 pm

2 stops9h 08m

Des Moines

Sat 11/29

6:17 am-4:52 pm

2 stops9h 35m

$2,454

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Syracuse to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then April is your next best option. Flight prices from Syracuse to Des Moines during April average around $298.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Syracuse to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $337. Flights from Syracuse to Des Moines on a Monday will generally be more expensive and average around $602. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Syracuse to Des Moines in the afternoon for as low as $366. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $445. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Syracuse to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Des Moines (SYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Des Moines

Direct flights

None
There are no direct flights from Syracuse to Des Moines. There are no popular flight routes from Syracuse to Des Moines.
Search flight deals

  • How far is Syracuse Hancock Intl to Des Moines by plane?

    Syracuse Hancock Intl and Des Moines are 896.5 mi apart from one another. Flights usually cover this in 4h 48m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Des Moines?

Best airlines flying from Syracuse to Des Moines

Compare and see reviews for airlines that fly from Syracuse to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
7,998 reviews
Search Delta flights
United AirlinesPriceFrom $300Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Des Moines?

It is quick and easy to find Syracuse to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Syracuse to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Des Moines?

Once you have performed a search for Syracuse to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Syracuse are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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