Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Syracuse to Des Moines from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Des Moines departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Syracuse to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:41 pm - 11:50 pm
SYR
-
DSM
5h 09m
1 stop
American Airlines Logo
5:00 am - 10:27 am
DSM
-
SYR
4h 27m
1 stop
$325American Airlines
Mon, Jun 1 - Sat, Jun 6
Multiple Airlines Logo
9:45 pm - 10:57 pm
SYR
-
DSM
26h 12m
1 stop
Multiple Airlines Logo
2:16 pm - 1:57 pm
DSM
-
SYR
22h 41m
2 stops
$337Multiple Airlines
Sun, May 17 - Wed, May 27
Allegiant Air Logo
7:39 pm - 5:40 pm
SYR
-
DSM
23h 01m
1 stop
Allegiant Air Logo
7:45 am - 5:13 pm
DSM
-
SYR
8h 28m
1 stop
$344Allegiant Air
Fri, May 15 - Sun, May 17
Allegiant Air Logo
9:45 pm - 10:57 pm
SYR
-
DSM
26h 12m
1 stop
Allegiant Air Logo
9:43 am - 9:31 am
DSM
-
SYR
22h 48m
1 stop
$348Allegiant Air
Sun, May 17 - Sun, May 24
Delta Logo
12:59 pm - 5:53 pm
SYR
-
DSM
5h 54m
1 stop
Delta Logo
6:15 am - 12:24 pm
DSM
-
SYR
5h 09m
1 stop
$353Delta
Tue, May 19 - Mon, May 25
American Airlines Logo
5:40 am - 11:30 am
SYR
-
DSM
6h 50m
1 stop
American Airlines Logo
1:38 pm - 10:39 pm
DSM
-
SYR
8h 01m
1 stop
$354American Airlines
Fri, May 15 - Tue, May 19
United Airlines Logo
6:00 am - 2:24 pm
SYR
-
DSM
9h 24m
2 stops
United Airlines Logo
11:23 am - 4:48 pm
DSM
-
SYR
4h 25m
1 stop
$359United Airlines
Wed, May 20 - Wed, May 27
Delta Logo
12:14 pm - 7:34 pm
SYR
-
DSM
8h 20m
1 stop
Delta Logo
2:33 pm - 11:52 pm
DSM
-
SYR
8h 19m
1 stop
$369Delta
Fri, May 15 - Thu, May 28
American Airlines Logo
7:34 pm - 12:06 am
SYR
-
DSM
5h 32m
1 stop
American Airlines Logo
1:41 pm - 10:53 pm
DSM
-
SYR
8h 12m
1 stop
$371American Airlines
Sat, Aug 1 - Tue, Aug 4
Multiple Airlines Logo
7:39 pm - 5:40 pm
SYR
-
DSM
23h 01m
1 stop
Multiple Airlines Logo
2:16 pm - 1:57 pm
DSM
-
SYR
22h 41m
2 stops
$374Multiple Airlines
Fri, May 15 - Wed, May 27

United Airlines flights from Syracuse to Des Moines

Our best United Airlines deals on Syracuse to Des Moines flight tickets
United Airlines
May 20
SYR6:00 amSyracuse Hancock Intl
9h 24m
2 stops
DSM2:24 pmDes Moines
May 27
DSM11:23 amDes Moines
4h 25m
1 stop
SYR4:48 pmSyracuse Hancock Intl
$359
United Airlines
May 19
SYR10:35 amSyracuse Hancock Intl
11h 48m
2 stops
DSM9:23 pmDes Moines
May 28
DSM1:35 pmDes Moines
9h 09m
1 stop
SYR11:44 pmSyracuse Hancock Intl
$424
United Airlines
May 15
SYR6:15 amSyracuse Hancock Intl
5h 22m
1 stop
DSM10:37 amDes Moines
May 19
DSM11:40 amDes Moines
4h 19m
1 stop
SYR4:59 pmSyracuse Hancock Intl
$444

American Airlines flights from Syracuse to Des Moines

Our best American Airlines deals on Syracuse to Des Moines flight tickets
American Airlines
Jun 1
SYR7:41 pmSyracuse Hancock Intl
5h 09m
1 stop
DSM11:50 pmDes Moines
Jun 6
DSM5:00 amDes Moines
4h 27m
1 stop
SYR10:27 amSyracuse Hancock Intl
$325
American Airlines
May 15
SYR5:40 amSyracuse Hancock Intl
6h 50m
1 stop
DSM11:30 amDes Moines
May 19
DSM1:38 pmDes Moines
8h 01m
1 stop
SYR10:39 pmSyracuse Hancock Intl
$354
American Airlines
Aug 1
SYR7:34 pmSyracuse Hancock Intl
5h 32m
1 stop
DSM12:06 amDes Moines
Aug 4
DSM1:41 pmDes Moines
8h 12m
1 stop
SYR10:53 pmSyracuse Hancock Intl
$371

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Mon 6/1

7:41 pm-11:50 pm

1 stop5h 09m

Des Moines

Sat 6/6

5:00 am-10:27 am

1 stop4h 27m

$325

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sun 5/17

9:45 pm-10:57 pm

1 stop26h 12m

Des Moines

Wed 5/27

2:16 pm-1:57 pm

2 stops22h 41m

$337

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

7:39 pm-5:40 pm

1 stop23h 01m

Des Moines

Sun 5/17

7:45 am-5:13 pm

1 stop8h 28m

$344

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sun 5/17

9:45 pm-10:57 pm

1 stop26h 12m

Des Moines

Sun 5/24

9:43 am-9:31 am

1 stop22h 48m

$348

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 5/19

12:59 pm-5:53 pm

1 stop5h 54m

Des Moines

Mon 5/25

6:15 am-12:24 pm

1 stop5h 09m

$353

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

5:40 am-11:30 am

1 stop6h 50m

Des Moines

Tue 5/19

1:38 pm-10:39 pm

1 stop8h 01m

$354

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Wed 5/20

6:00 am-2:24 pm

2 stops9h 24m

Des Moines

Wed 5/27

11:23 am-4:48 pm

1 stop4h 25m

$359

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

12:14 pm-7:34 pm

1 stop8h 20m

Des Moines

Thu 5/28

2:33 pm-11:52 pm

1 stop8h 19m

$369

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 8/1

7:34 pm-12:06 am

1 stop5h 32m

Des Moines

Tue 8/4

1:41 pm-10:53 pm

1 stop8h 12m

$371

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

7:39 pm-5:40 pm

1 stop23h 01m

Des Moines

Wed 5/27

2:16 pm-1:57 pm

2 stops22h 41m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from Syracuse to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then September is your next best option. Flight prices from Syracuse to Des Moines during September average around $308.

When to book flights from Syracuse to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Des Moines (SYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Des Moines

Fastest flight time

4h 26m

Direct flights

None
The fastest flight from Syracuse to Des Moines takes 4h 26m
There are no direct flights from Syracuse to Des Moines. There are no popular flight routes from Syracuse to Des Moines.
Search flight deals

Frequently asked questions about flying from Syracuse to Des Moines

  • How far is Syracuse Hancock Intl to Des Moines by plane?

    Syracuse Hancock Intl and Des Moines are 896.5 mi apart from one another. Flights usually cover this in 4h 26m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Des Moines?

Best airlines flying from Syracuse to Des Moines

Compare and see reviews for airlines that fly from Syracuse to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,673 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,460 reviews
Search Delta flights
United AirlinesPriceFrom $301Free CancellationRating
7.4
9,679 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Des Moines?

It is quick and easy to find Syracuse to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Syracuse to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Des Moines?

Once you have performed a search for Syracuse to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Syracuse are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 6/1
Mon 6/8
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States