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Cheap flights from Syracuse to Des Moines from $179

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Des Moines departing on 4/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Syracuse to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:40 am - 10:26 am
SYR
-
DSM
5h 46m
1 stop
American Airlines Logo
5:01 pm - 11:05 pm
DSM
-
SYR
5h 04m
1 stop
$311American Airlines
Sat, May 16 - Tue, May 19
American Airlines Logo
5:40 am - 10:26 am
SYR
-
DSM
5h 46m
1 stop
American Airlines Logo
5:01 pm - 11:05 pm
DSM
-
SYR
5h 04m
1 stop
$315American Airlines
Fri, May 15 - Tue, May 19
American Airlines Logo
5:40 am - 10:26 am
SYR
-
DSM
5h 46m
1 stop
American Airlines Logo
11:09 am - 6:34 pm
DSM
-
SYR
6h 25m
1 stop
$325American Airlines
Fri, May 15 - Tue, May 19
United Airlines Logo
2:50 pm - 11:17 pm
SYR
-
DSM
9h 27m
2 stops
United Airlines Logo
11:40 am - 4:59 pm
DSM
-
SYR
4h 19m
1 stop
$336United Airlines
Sat, Apr 25 - Sat, May 2
United Airlines Logo
6:00 am - 12:29 pm
SYR
-
DSM
7h 29m
2 stops
United Airlines Logo
11:40 am - 8:20 pm
DSM
-
SYR
7h 40m
2 stops
$342United Airlines
Sat, Apr 25 - Sat, May 2
United Airlines Logo
8:28 am - 4:15 pm
SYR
-
DSM
8h 47m
1 stop
United Airlines Logo
10:02 am - 8:20 pm
DSM
-
SYR
9h 18m
2 stops
$355United Airlines
Fri, Apr 24 - Sat, May 2
Delta Logo
5:50 am - 9:54 am
SYR
-
DSM
5h 04m
1 stop
Delta Logo
4:23 pm - 11:12 pm
DSM
-
SYR
5h 49m
1 stop
$365Delta
Mon, Apr 13 - Mon, Apr 20
Delta Logo
6:15 am - 9:46 am
SYR
-
DSM
4h 31m
1 stop
Delta Logo
2:33 pm - 11:52 pm
DSM
-
SYR
8h 19m
1 stop
$376Delta
Sat, May 16 - Wed, May 20
Delta Logo
7:30 am - 2:07 pm
SYR
-
DSM
7h 37m
1 stop
Delta Logo
5:35 pm - 11:32 pm
DSM
-
SYR
4h 57m
1 stop
$392Delta
Wed, Jun 10 - Sun, Jun 14
American Airlines Logo
5:15 am - 8:54 am
SYR
-
DSM
4h 39m
1 stop
American Airlines Logo
6:00 am - 11:38 am
DSM
-
SYR
4h 38m
1 stop
$394American Airlines
Thu, Mar 26 - Sun, Mar 29

Delta flights from Syracuse to Des Moines

Our best Delta deals on Syracuse to Des Moines flight tickets
Delta
Apr 13
SYR5:50 amSyracuse Hancock Intl
5h 04m
1 stop
DSM9:54 amDes Moines
Apr 20
DSM4:23 pmDes Moines
5h 49m
1 stop
SYR11:12 pmSyracuse Hancock Intl
$365
Delta
May 16
SYR6:15 amSyracuse Hancock Intl
4h 31m
1 stop
DSM9:46 amDes Moines
May 20
DSM2:33 pmDes Moines
8h 19m
1 stop
SYR11:52 pmSyracuse Hancock Intl
$376
Delta
Jun 10
SYR7:30 amSyracuse Hancock Intl
7h 37m
1 stop
DSM2:07 pmDes Moines
Jun 14
DSM5:35 pmDes Moines
4h 57m
1 stop
SYR11:32 pmSyracuse Hancock Intl
$392

Allegiant Air flights from Syracuse to Des Moines

Our best Allegiant Air deals on Syracuse to Des Moines flight tickets
Allegiant Air
Apr 30
SYR9:45 pmSyracuse Hancock Intl
25h 57m
1 stop
DSM10:42 pmDes Moines
May 7
DSM7:45 amDes Moines
25h 56m
1 stop
SYR10:41 amSyracuse Hancock Intl
$396
Allegiant Air
Apr 26
SYR9:45 pmSyracuse Hancock Intl
25h 57m
1 stop
DSM10:42 pmDes Moines
May 1
DSM10:23 amDes Moines
7h 31m
1 stop
SYR6:54 pmSyracuse Hancock Intl
$425
Allegiant Air
May 15
SYR10:29 amSyracuse Hancock Intl
11h 30m
1 stop
DSM8:59 pmDes Moines
May 18
DSM10:23 amDes Moines
7h 26m
1 stop
SYR6:49 pmSyracuse Hancock Intl
$594

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 5/16

5:40 am-10:26 am

1 stop5h 46m

Des Moines

Tue 5/19

5:01 pm-11:05 pm

1 stop5h 04m

$311

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

5:40 am-10:26 am

1 stop5h 46m

Des Moines

Tue 5/19

5:01 pm-11:05 pm

1 stop5h 04m

$315

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

5:40 am-10:26 am

1 stop5h 46m

Des Moines

Tue 5/19

11:09 am-6:34 pm

1 stop6h 25m

$325

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 4/25

2:50 pm-11:17 pm

2 stops9h 27m

Des Moines

Sat 5/2

11:40 am-4:59 pm

1 stop4h 19m

$336

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 4/25

6:00 am-12:29 pm

2 stops7h 29m

Des Moines

Sat 5/2

11:40 am-8:20 pm

2 stops7h 40m

$342

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 4/24

8:28 am-4:15 pm

1 stop8h 47m

Des Moines

Sat 5/2

10:02 am-8:20 pm

2 stops9h 18m

$355

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Mon 4/13

5:50 am-9:54 am

1 stop5h 04m

Des Moines

Mon 4/20

4:23 pm-11:12 pm

1 stop5h 49m

$365

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 5/16

6:15 am-9:46 am

1 stop4h 31m

Des Moines

Wed 5/20

2:33 pm-11:52 pm

1 stop8h 19m

$376

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Wed 6/10

7:30 am-2:07 pm

1 stop7h 37m

Des Moines

Sun 6/14

5:35 pm-11:32 pm

1 stop4h 57m

$392
Quickest round-trip

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 3/26

5:15 am-8:54 am

1 stop4h 39m

Des Moines

Sun 3/29

6:00 am-11:38 am

1 stop4h 38m

$394

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Syracuse to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then December is your next best option. Flight prices from Syracuse to Des Moines during December average around $308.

When to book flights from Syracuse to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Des Moines (SYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Des Moines

Fastest flight time

4h 56m

Direct flights

None
The fastest flight from Syracuse to Des Moines takes 4h 56m
There are no direct flights from Syracuse to Des Moines. There are no popular flight routes from Syracuse to Des Moines.
Search flight deals

  • How far is Syracuse Hancock Intl to Des Moines by plane?

    Syracuse Hancock Intl and Des Moines are 896.5 mi apart from one another. Flights usually cover this in 4h 56m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Des Moines?

Best airlines flying from Syracuse to Des Moines

Compare and see reviews for airlines that fly from Syracuse to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,468 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,286 reviews
Search Delta flights
United AirlinesPriceFrom $273Free CancellationRating
7.4
9,435 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Des Moines?

It is quick and easy to find Syracuse to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Syracuse to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Des Moines?

Once you have performed a search for Syracuse to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Syracuse are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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