Which layover airport offers the lowest fares from Syracuse to Des Moines?

Flights via Chicago (ORD) offer the lowest average round-trip price of $475.

What airlines fly to Des Moines?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Des Moines from Syracuse according to our data. Delta is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Syracuse Hancock Intl to Des Moines?

Allegiant Air is the most popular carrier operating from Syracuse Hancock Intl to Des Moines

Which layover airport has the shortest travel time from Syracuse to Des Moines?

Flights connecting via Detroit (DTW) have the shortest average one-way travel time: 4h 20m.

Which airport is the most popular layover for flights between Syracuse and Des Moines?

Chicago (ORD) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest connection time from Syracuse to Des Moines?

Detroit (DTW) has the shortest average layover time for this route: 1h 05m.

When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

Prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport refresh daily.

How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Des Moines Airport?

As of October 2026, there are 3 operators available to choose from for flights from Syracuse Hancock Intl Airport to Des Moines Airport.

How old do you have to be to fly from Syracuse Hancock Intl Airport to Des Moines Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$201 Cheap Flights from Syracuse to Des Moines in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Syracuse to Des Moines

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:07 am - 11:48 amSYR Syracuse Hancock Intl-DSM Des Moines

6h 41m1 stop New York LaGuardia

5:29 pm - 11:02 pmDSM Des Moines-SYR Syracuse Hancock Intl

4h 33m1 stop Detroit Metropolitan Wayne County

$349Delta

Sat, Nov 21 - Tue, Dec 1

6:00 am - 9:44 amSYR Syracuse Hancock Intl-DSM Des Moines

4h 44m1 stop Detroit Metropolitan Wayne County

5:29 pm - 11:02 pmDSM Des Moines-SYR Syracuse Hancock Intl

4h 33m1 stop Detroit Metropolitan Wayne County

$349Delta

Sun, Nov 22 - Tue, Dec 1

1:00 pm - 7:25 pmSYR Syracuse Hancock Intl-DSM Des Moines

7h 25m1 stop New York LaGuardia

7:25 am - 4:21 pmDSM Des Moines-SYR Syracuse Hancock Intl

7h 56m1 stop New York LaGuardia

$349Delta

Sat, Dec 19 - Tue, Jan 19

5:00 am - 9:12 amSYR Syracuse Hancock Intl-DSM Des Moines

5h 12m1 stop Chicago O'Hare Intl

2:39 pm - 11:59 pmDSM Des Moines-SYR Syracuse Hancock Intl

8h 20m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

$387American Airlines

Sun, Dec 20 - Tue, Jan 19

5:00 am - 9:12 amSYR Syracuse Hancock Intl-DSM Des Moines

5h 12m1 stop Chicago O'Hare Intl

7:36 am - 4:32 pmDSM Des Moines-SYR Syracuse Hancock Intl

7h 56m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

$387American Airlines

Sun, Dec 20 - Tue, Jan 19

8:00 am - 4:07 pmSYR Syracuse Hancock Intl-DSM Des Moines

9h 07m1 stop Denver Intl

3:19 pm - 9:17 pmDSM Des Moines-SYR Syracuse Hancock Intl

4h 58m1 stop Chicago O'Hare Intl

$396United Airlines

Thu, Nov 19 - Sun, Nov 22

8:00 am - 4:07 pmSYR Syracuse Hancock Intl-DSM Des Moines

9h 07m1 stop Denver Intl

6:05 am - 2:12 pmDSM Des Moines-SYR Syracuse Hancock Intl

7h 07m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$402United Airlines

Thu, Nov 19 - Sun, Nov 22

5:00 am - 9:12 amSYR Syracuse Hancock Intl-DSM Des Moines

5h 12m1 stop Chicago O'Hare Intl

2:39 pm - 11:59 pmDSM Des Moines-SYR Syracuse Hancock Intl

8h 20m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

$420American Airlines

Sun, Dec 20 - Tue, Jan 19

1:44 pm - 3:07 pmSYR Syracuse Hancock Intl-DSM Des Moines

26h 23m1 stop Sarasota Bradenton Intl

9:20 pm - 9:28 amDSM Des Moines-SYR Syracuse Hancock Intl

35h 08m2 stops Nashville Intl Orlando

$465Multiple Airlines

Wed, Nov 18 - Wed, Nov 25

5:37 pm - 10:21 amSYR Syracuse Hancock Intl-DSM Des Moines

17h 44m1 stop Punta Gorda

7:05 pm - 5:39 pmDSM Des Moines-SYR Syracuse Hancock Intl

21h 34m1 stop Orlando Sanford Intl

$507Allegiant Air

Wed, Nov 25 - Sun, Nov 29

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American Airlines flights from Syracuse to Des Moines

Our best American Airlines deals on Syracuse to Des Moines flight tickets

American Airlines

Dec 20

SYR5:00 amSyracuse Hancock Intl

5h 12m

1 stop

DSM9:12 amDes Moines

Jan 19

DSM2:39 pmDes Moines

8h 20m

2 stops

SYR11:59 pmSyracuse Hancock Intl

$387

American Airlines

Dec 20

SYR5:00 amSyracuse Hancock Intl

5h 12m

1 stop

DSM9:12 amDes Moines

Jan 19

DSM2:39 pmDes Moines

8h 20m

2 stops

SYR11:59 pmSyracuse Hancock Intl

$420

American Airlines

Nov 18

SYR6:00 amSyracuse Hancock Intl

8h 28m

2 stops

DSM1:28 pmDes Moines

Nov 25

DSM1:58 pmDes Moines

8h 54m

1 stop

SYR11:52 pmSyracuse Hancock Intl

$469

United Airlines flights from Syracuse to Des Moines

Our best United Airlines deals on Syracuse to Des Moines flight tickets

United Airlines

Nov 19

SYR8:00 amSyracuse Hancock Intl

9h 07m

1 stop

DSM4:07 pmDes Moines

Nov 22

DSM3:19 pmDes Moines

4h 58m

1 stop

SYR9:17 pmSyracuse Hancock Intl

$396

United Airlines

Nov 19

SYR8:00 amSyracuse Hancock Intl

9h 07m

1 stop

DSM4:07 pmDes Moines

Nov 22

DSM6:05 amDes Moines

7h 07m

2 stops

SYR2:12 pmSyracuse Hancock Intl

$402

United Airlines

Nov 19

SYR10:17 amSyracuse Hancock Intl

8h 11m

2 stops

DSM5:28 pmDes Moines

Nov 22

DSM6:05 amDes Moines

7h 07m

2 stops

SYR2:12 pmSyracuse Hancock Intl

$445

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Sat 11/21

6:07 am-11:48 am

1 stop6h 41m

Des Moines

Tue 12/1

5:29 pm-11:02 pm

1 stop4h 33m

$349

Quickest round-trip

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Sun 11/22

6:00 am-9:44 am

1 stop4h 44m

Des Moines

Tue 12/1

5:29 pm-11:02 pm

1 stop4h 33m

$349

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Sat 12/19

1:00 pm-7:25 pm

1 stop7h 25m

Des Moines

Tue 1/19

7:25 am-4:21 pm

1 stop7h 56m

$349

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Sun 12/20

5:00 am-9:12 am

1 stop5h 12m

Des Moines

Tue 1/19

2:39 pm-11:59 pm

2 stops8h 20m

$387

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Sun 12/20

5:00 am-9:12 am

1 stop5h 12m

Des Moines

Tue 1/19

7:36 am-4:32 pm

2 stops7h 56m

$387

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Thu 11/19

8:00 am-4:07 pm

1 stop9h 07m

Des Moines

Sun 11/22

3:19 pm-9:17 pm

1 stop4h 58m

$396

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Thu 11/19

8:00 am-4:07 pm

1 stop9h 07m

Des Moines

Sun 11/22

6:05 am-2:12 pm

2 stops7h 07m

$402

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Sun 12/20

5:00 am-9:12 am

1 stop5h 12m

Des Moines

Tue 1/19

2:39 pm-11:59 pm

2 stops8h 20m

$420

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Wed 11/18

1:44 pm-3:07 pm

1 stop26h 23m

Des Moines

Wed 11/25

9:20 pm-9:28 am

2 stops35h 08m

$465

SyracuseDes Moines

SYR Syracuse Hancock Intl - DSM Des Moines

SYRDSM

Syracuse Hancock Intl

Wed 11/25

5:37 pm-10:21 am

1 stop17h 44m

Des Moines

Sun 11/29

7:05 pm-5:39 pm

1 stop21h 34m

$507

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Syracuse to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between Syracuse and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $432 to $695.
The lowest price recently found on this route was $349.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then September is your next best option. Flight prices from Syracuse to Des Moines during September average around $384.

When to book flights from Syracuse to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Syracuse to Des Moines (SYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Des Moines

Best Price Found	$201
Fastest flight time	5h 32m
Direct flights	None

The best one-way flight to Des Moines from Syracuse in the past 72 hours is $201. The best round-trip flight deal from Syracuse to Des Moines found on momondo in the last 72 hours is $349.

The fastest flight from Syracuse to Des Moines takes 5h 32m

There are no direct flights from Syracuse to Des Moines. There are no popular flight routes from Syracuse to Des Moines.

Search flight deals

Frequently asked questions about flying from Syracuse to Des Moines

How far is Syracuse Hancock Intl to Des Moines by plane?
Syracuse Hancock Intl and Des Moines are 896.5 mi apart from one another. Flights usually cover this in 5h 32m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport?
Prices for flights from Syracuse Hancock Intl Airport to Des Moines Airport refresh daily.
How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Des Moines Airport?
As of October 2026, there are 3 operators available to choose from for flights from Syracuse Hancock Intl Airport to Des Moines Airport.
How old do you have to be to fly from Syracuse Hancock Intl Airport to Des Moines Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Syracuse to Des Moines?
momondo data reveals that the most frequently booked airline on the route from Syracuse to Des Moines is Delta, representing 51% of all bookings. The subsequent popular airlines are American Airlines at 31% and United Airlines at 19%.

Best airlines flying from Syracuse to Des Moines

Compare and see reviews for airlines that fly from Syracuse to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $258	Free Cancellation	Rating 7.3 10,393 reviews	Search United Airlines flights
Delta	PriceFrom $270	Free Cancellation	Rating 7.8 8,654 reviews	Search Delta flights
American Airlines	PriceFrom $308	Free Cancellation	Rating 7.0 12,179 reviews	Search American Airlines flights

West Des Moines

Ames

Ankeny

Clive

Altoona

Pella

Urbandale

Newton

Osceola

Boone

Johnston

Oskaloosa

Grinnell

Norwalk

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Des Moines?

It is quick and easy to find Syracuse to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Syracuse to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Des Moines?

Once you have performed a search for Syracuse to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Syracuse to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Syracuse are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Cheap flights from Syracuse to Des Moines from $201

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Des Moines departing on 12/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Syracuse to Des Moines

Our best American Airlines deals on Syracuse to Des Moines flight tickets

United Airlines flights from Syracuse to Des Moines

Our best United Airlines deals on Syracuse to Des Moines flight tickets

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How to get the cheapest flight ticket from Syracuse to Des Moines

What is the typical price of a round-trip flight between Syracuse and Des Moines?

What is the cheapest month to fly to Des Moines?

What is the cheapest airline that flies from Syracuse Hancock Intl to Des Moines?

What airlines fly to Des Moines?

Which airport is the most popular layover for flights between Syracuse and Des Moines?

Which layover airport offers the lowest fares from Syracuse to Des Moines?

Which layover airport has the shortest travel time from Syracuse to Des Moines?

Which layover airport has the shortest connection time from Syracuse to Des Moines?

When to book flights from Syracuse to Des Moines

Cheap Syracuse to Des Moines (SYR to DSM) flight deals and tips

Best Price Found

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Frequently asked questions about flying from Syracuse to Des Moines

Best airlines flying from Syracuse to Des Moines

Compare and see reviews for airlines that fly from Syracuse to Des Moines with momondo

Traveling to a place near Des Moines?

Why use momondo?

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

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Find better results for your trip to the United States

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Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Des Moines

List of cabin classes available on flights landing in Des Moines. Availability may vary depending on flight origin and airline.

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