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Cheap flights from St. Louis to Des Moines from $151

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Des Moines departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:08 pm - 1:34 pm
STL
-
DSM
17h 26m
1 stop
Multiple Airlines Logo
6:00 am - 6:36 pm
DSM
-
STL
12h 36m
2 stops
$239Multiple Airlines
Tue, Jul 14 - Sun, Jul 19
Delta Logo
6:21 am - 10:14 am
STL
-
DSM
3h 53m
1 stop
Delta Logo
6:03 pm - 11:23 pm
DSM
-
STL
5h 20m
1 stop
$293Delta
Wed, Jun 17 - Wed, Jun 24
Delta Logo
6:21 am - 10:14 am
STL
-
DSM
3h 53m
1 stop
Delta Logo
6:50 am - 10:28 am
DSM
-
STL
3h 38m
1 stop
$297Delta
Wed, Jun 17 - Sat, Jun 20
American Airlines Logo
8:14 pm - 12:35 am
STL
-
DSM
4h 21m
1 stop
American Airlines Logo
7:02 pm - 11:59 pm
DSM
-
STL
4h 57m
1 stop
$298American Airlines
Tue, Jun 23 - Thu, Jun 25
Frontier Logo
7:38 pm - 1:31 pm
STL
-
DSM
17h 53m
1 stop
Frontier Logo
2:16 pm - 7:23 pm
DSM
-
STL
5h 07m
1 stop
$300Frontier
Thu, Jun 11 - Wed, Jun 17
Delta Logo
5:36 pm - 9:08 pm
STL
-
DSM
3h 32m
1 stop
Delta Logo
6:03 pm - 11:23 pm
DSM
-
STL
5h 20m
1 stop
$301Delta
Mon, Jun 15 - Tue, Jun 16
United Airlines Logo
5:29 pm - 10:51 pm
STL
-
DSM
5h 22m
1 stop
United Airlines Logo
6:00 am - 12:11 pm
DSM
-
STL
6h 11m
1 stop
$305United Airlines
Tue, Jun 23 - Thu, Jun 25
Southwest Logo
5:55 pm - 10:45 pm
STL
-
DSM
4h 50m
1 stop
Southwest Logo
5:10 am - 9:10 am
DSM
-
STL
4h 00m
1 stop
$307Southwest
Tue, Jun 16 - Thu, Jun 18
Southwest Logo
5:55 pm - 10:45 pm
STL
-
DSM
4h 50m
1 stop
Southwest Logo
4:40 pm - 10:50 pm
DSM
-
STL
6h 10m
1 stop
$309Southwest
Tue, Jun 9 - Thu, Jun 11
Southwest Logo
6:30 pm - 11:30 pm
STL
-
DSM
5h 00m
1 stop
Southwest Logo
5:20 am - 2:50 pm
DSM
-
STL
9h 30m
2 stops
$312Southwest
Mon, Jun 15 - Tue, Jun 16

Delta flights from St. Louis to Des Moines

Our best Delta deals on St. Louis to Des Moines flight tickets
Delta
Jun 17
STL6:21 amLambert-St Louis
3h 53m
1 stop
DSM10:14 amDes Moines
Jun 24
DSM6:03 pmDes Moines
5h 20m
1 stop
STL11:23 pmLambert-St Louis
$293
Delta
Jun 17
STL6:21 amLambert-St Louis
3h 53m
1 stop
DSM10:14 amDes Moines
Jun 20
DSM6:50 amDes Moines
3h 38m
1 stop
STL10:28 amLambert-St Louis
$297
Delta
Jun 15
STL5:36 pmLambert-St Louis
3h 32m
1 stop
DSM9:08 pmDes Moines
Jun 16
DSM6:03 pmDes Moines
5h 20m
1 stop
STL11:23 pmLambert-St Louis
$301

United Airlines flights from St. Louis to Des Moines

Our best United Airlines deals on St. Louis to Des Moines flight tickets
United Airlines
Jun 23
STL5:29 pmLambert-St Louis
5h 22m
1 stop
DSM10:51 pmDes Moines
Jun 25
DSM6:00 amDes Moines
6h 11m
1 stop
STL12:11 pmLambert-St Louis
$305
United Airlines
Jul 14
STL5:33 pmLambert-St Louis
5h 18m
1 stop
DSM10:51 pmDes Moines
Jul 15
DSM5:17 pmDes Moines
6h 40m
1 stop
STL11:57 pmLambert-St Louis
$363
United Airlines
Aug 13
STL5:30 pmLambert-St Louis
5h 23m
1 stop
DSM10:53 pmDes Moines
Aug 17
DSM6:55 pmDes Moines
4h 04m
1 stop
STL10:59 pmLambert-St Louis
$387

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 7/14

8:08 pm-1:34 pm

1 stop17h 26m

Des Moines

Sun 7/19

6:00 am-6:36 pm

2 stops12h 36m

$239

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 6/17

6:21 am-10:14 am

1 stop3h 53m

Des Moines

Wed 6/24

6:03 pm-11:23 pm

1 stop5h 20m

$293
Quickest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 6/17

6:21 am-10:14 am

1 stop3h 53m

Des Moines

Sat 6/20

6:50 am-10:28 am

1 stop3h 38m

$297

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/23

8:14 pm-12:35 am

1 stop4h 21m

Des Moines

Thu 6/25

7:02 pm-11:59 pm

1 stop4h 57m

$298

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/11

7:38 pm-1:31 pm

1 stop17h 53m

Des Moines

Wed 6/17

2:16 pm-7:23 pm

1 stop5h 07m

$300

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 6/15

5:36 pm-9:08 pm

1 stop3h 32m

Des Moines

Tue 6/16

6:03 pm-11:23 pm

1 stop5h 20m

$301

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/23

5:29 pm-10:51 pm

1 stop5h 22m

Des Moines

Thu 6/25

6:00 am-12:11 pm

1 stop6h 11m

$305

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/16

5:55 pm-10:45 pm

1 stop4h 50m

Des Moines

Thu 6/18

5:10 am-9:10 am

1 stop4h 00m

$307

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/9

5:55 pm-10:45 pm

1 stop4h 50m

Des Moines

Thu 6/11

4:40 pm-10:50 pm

1 stop6h 10m

$309

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 6/15

6:30 pm-11:30 pm

1 stop5h 00m

Des Moines

Tue 6/16

5:20 am-2:50 pm

2 stops9h 30m

$312

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from St. Louis to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then April is your next best option. Flight prices from St. Louis to Des Moines during April average around $0.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from St. Louis to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $338. Flights from St. Louis to Des Moines on a Monday will generally be more expensive and average around $725. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from St. Louis to Des Moines in the morning for as low as $487. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $680. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Lambert-St Louis - Des Moines flight prices

What cabin class options are available on St. Louis to Des Moines flights?

There is only 1 cabin class available to choose from on St. Louis to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Des Moines flights?

You could potentially save up to 56% on your flight if you consider stops on a St. Louis to Des Moines flight.

When to book flights from St. Louis to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Des Moines (STL to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Des Moines

Fastest flight time

3h 36m

Direct flights

None
The fastest flight from St. Louis to Des Moines takes 3h 36m
There are no direct flights from St. Louis to Des Moines. There are no popular flight routes from St. Louis to Des Moines.
Search flight deals

Frequently asked questions about flying from St. Louis to Des Moines

  • How far is Lambert-St Louis to Des Moines by plane?

    A flight from Lambert-St Louis to Des Moines will travel around 273.0 mi. 3h 36m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Des Moines Airport?

    Prices for flights from Lambert-St Louis Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Des Moines Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Des Moines?

  • What is the most popular airline from St. Louis to Des Moines?

Best airlines flying from St. Louis to Des Moines

Compare and see reviews for airlines that fly from St. Louis to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
7.9
4,270 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Des Moines?

Finding the right flight to Des Moines from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from St. Louis to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Des Moines?

Once you have performed a search for St. Louis to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Des Moines right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Des Moines from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Des Moines trip

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