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Cheap flights from St. Louis to Des Moines from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Des Moines departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:55 pm - 9:15 pm
STL
-
DSM
5h 20m
1 stop
Southwest Logo
6:30 pm - 11:10 pm
DSM
-
STL
4h 40m
1 stop
$279Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
3:55 pm - 10:10 pm
STL
-
DSM
6h 15m
1 stop
Southwest Logo
6:55 am - 1:00 pm
DSM
-
STL
6h 05m
2 stops
$284Southwest
Tue, May 5 - Tue, May 12
American Airlines Logo
5:21 pm - 11:49 pm
STL
-
DSM
6h 28m
1 stop
American Airlines Logo
8:03 pm - 11:56 pm
DSM
-
STL
3h 53m
1 stop
$288American Airlines
Tue, May 12 - Thu, May 14
Southwest Logo
3:10 pm - 10:10 pm
STL
-
DSM
7h 00m
2 stops
Southwest Logo
5:30 am - 12:50 pm
DSM
-
STL
7h 20m
2 stops
$289Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
3:10 pm - 10:10 pm
STL
-
DSM
7h 00m
2 stops
Southwest Logo
5:25 am - 10:15 am
DSM
-
STL
4h 50m
1 stop
$293Southwest
Wed, May 6 - Thu, May 7
American Airlines Logo
5:51 am - 10:26 am
STL
-
DSM
4h 35m
1 stop
American Airlines Logo
8:03 pm - 11:46 pm
DSM
-
STL
3h 43m
1 stop
$297American Airlines
Mon, Apr 27 - Mon, Apr 27
Southwest Logo
6:10 am - 1:30 pm
STL
-
DSM
7h 20m
2 stops
Southwest Logo
5:35 am - 10:30 am
DSM
-
STL
4h 55m
1 stop
$302Southwest
Sat, May 2 - Sat, May 9
Southwest Logo
6:10 am - 1:30 pm
STL
-
DSM
7h 20m
2 stops
Southwest Logo
5:35 am - 4:25 pm
DSM
-
STL
10h 50m
2 stops
$307Southwest
Sat, May 2 - Sat, May 9
Southwest Logo
5:40 am - 11:45 am
STL
-
DSM
6h 05m
1 stop
Southwest Logo
4:20 pm - 12:15 am
DSM
-
STL
7h 55m
2 stops
$312Southwest
Mon, May 11 - Fri, May 15
Southwest Logo
5:40 am - 11:45 am
STL
-
DSM
6h 05m
1 stop
Southwest Logo
4:20 pm - 7:45 pm
DSM
-
STL
3h 25m
1 stop
$317Southwest
Fri, May 8 - Sun, May 10

American Airlines flights from St. Louis to Des Moines

Our best American Airlines deals on St. Louis to Des Moines flight tickets
American Airlines
May 12
STL5:21 pmLambert-St Louis
6h 28m
1 stop
DSM11:49 pmDes Moines
May 14
DSM8:03 pmDes Moines
3h 53m
1 stop
STL11:56 pmLambert-St Louis
$288
American Airlines
Apr 27
STL5:51 amLambert-St Louis
4h 35m
1 stop
DSM10:26 amDes Moines
Apr 27
DSM8:03 pmDes Moines
3h 43m
1 stop
STL11:46 pmLambert-St Louis
$297
American Airlines
Apr 10
STL6:11 pmLambert-St Louis
5h 48m
1 stop
DSM11:59 pmDes Moines
Apr 12
DSM8:03 pmDes Moines
3h 43m
1 stop
STL11:46 pmLambert-St Louis
$426

Delta flights from St. Louis to Des Moines

Our best Delta deals on St. Louis to Des Moines flight tickets
Delta
May 12
STL6:45 amLambert-St Louis
10h 21m
2 stops
DSM5:06 pmDes Moines
May 14
DSM5:28 pmDes Moines
5h 53m
1 stop
STL11:21 pmLambert-St Louis
$364
Delta
Apr 10
STL5:25 pmLambert-St Louis
3h 45m
1 stop
DSM9:10 pmDes Moines
Apr 12
DSM5:20 pmDes Moines
6h 38m
1 stop
STL11:58 pmLambert-St Louis
$379
Delta
Apr 10
STL6:32 amLambert-St Louis
9h 10m
2 stops
DSM3:42 pmDes Moines
Apr 12
DSM6:55 amDes Moines
4h 53m
1 stop
STL11:48 amLambert-St Louis
$451

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 8, 2026.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/5

3:55 pm-9:15 pm

1 stop5h 20m

Des Moines

Tue 5/12

6:30 pm-11:10 pm

1 stop4h 40m

$279

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/5

3:55 pm-10:10 pm

1 stop6h 15m

Des Moines

Tue 5/12

6:55 am-1:00 pm

2 stops6h 05m

$284

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/12

5:21 pm-11:49 pm

1 stop6h 28m

Des Moines

Thu 5/14

8:03 pm-11:56 pm

1 stop3h 53m

$288

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/5

3:10 pm-10:10 pm

2 stops7h 00m

Des Moines

Tue 5/12

5:30 am-12:50 pm

2 stops7h 20m

$289

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 5/6

3:10 pm-10:10 pm

2 stops7h 00m

Des Moines

Thu 5/7

5:25 am-10:15 am

1 stop4h 50m

$293
Quickest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 4/27

5:51 am-10:26 am

1 stop4h 35m

Des Moines

Mon 4/27

8:03 pm-11:46 pm

1 stop3h 43m

$297

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 5/2

6:10 am-1:30 pm

2 stops7h 20m

Des Moines

Sat 5/9

5:35 am-10:30 am

1 stop4h 55m

$302

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 5/2

6:10 am-1:30 pm

2 stops7h 20m

Des Moines

Sat 5/9

5:35 am-4:25 pm

2 stops10h 50m

$307

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 5/11

5:40 am-11:45 am

1 stop6h 05m

Des Moines

Fri 5/15

4:20 pm-12:15 am

2 stops7h 55m

$312

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 5/8

5:40 am-11:45 am

1 stop6h 05m

Des Moines

Sun 5/10

4:20 pm-7:45 pm

1 stop3h 25m

$317

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from St. Louis to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Des Moines?

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from St. Louis to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $338. Flights from St. Louis to Des Moines on a Monday will generally be more expensive and average around $725. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from St. Louis to Des Moines in the evening for as low as $280. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $492. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Lambert-St Louis - Des Moines flight prices

What cabin class options are available on Lambert-St Louis to Des Moines flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Des Moines flights?

You could potentially save up to 61% on your flight if you consider stops on a St. Louis to Des Moines flight.

When to book flights from St. Louis to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Des Moines (STL to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Des Moines

Fastest flight time

3h 59m

Direct flights

None
The fastest flight from St. Louis to Des Moines takes 3h 59m
There are no direct flights from St. Louis to Des Moines. There are no popular flight routes from St. Louis to Des Moines.
Search flight deals

Frequently asked questions about flying from St. Louis to Des Moines

  • How far is Lambert-St Louis to Des Moines by plane?

    A flight from Lambert-St Louis to Des Moines will travel around 273.0 mi. 3h 59m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Des Moines Airport?

    Prices for flights from Lambert-St Louis Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Des Moines Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Des Moines?

  • What is the most popular airline from St. Louis to Des Moines?

Best airlines flying from St. Louis to Des Moines

Compare and see reviews for airlines that fly from St. Louis to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,337 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Des Moines?

Finding the right flight to Des Moines from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from St. Louis to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Des Moines?

Once you have performed a search for St. Louis to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Des Moines right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Des Moines from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Des Moines trip

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