Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from St. Louis to Des Moines from $59

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Des Moines departing on 2/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from St. Louis to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:37 pm - 11:23 pm
STL
-
DSM
7h 46m1 stop
American Airlines Logo
5:51 pm - 10:55 pm
DSM
-
STL
5h 04m1 stop
$181American Airlines
Thu, Jan 8 - Thu, Jan 15
United Airlines Logo
8:05 am - 2:33 pm
STL
-
DSM
6h 28m1 stop
United Airlines Logo
7:50 am - 12:29 pm
DSM
-
STL
4h 39m1 stop
$241United Airlines
Wed, Jan 21 - Sat, Jan 24
Southwest Logo
9:10 pm - 10:15 pm
STL
-
DSM
1h 05mnonstop
Southwest Logo
11:30 am - 8:15 pm
DSM
-
STL
8h 45m1 stop
$250Southwest
Thu, Feb 5 - Fri, Feb 6
American Airlines Logo
3:37 pm - 11:23 pm
STL
-
DSM
7h 46m1 stop
American Airlines Logo
5:01 pm - 9:15 pm
DSM
-
STL
4h 14m1 stop
$255American Airlines
Thu, Feb 5 - Fri, Feb 6
Delta Logo
6:10 am - 10:19 am
STL
-
DSM
4h 09m1 stop
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
$305Delta
Thu, Jan 8 - Thu, Jan 15
Southwest Logo
12:20 pm - 9:20 pm
STL
-
DSM
9h 00m2 stops
Southwest Logo
11:30 am - 8:15 pm
DSM
-
STL
8h 45m1 stop
$334Southwest
Thu, Feb 5 - Fri, Feb 6
Delta Logo
6:05 am - 11:28 am
STL
-
DSM
5h 23m1 stop
Delta Logo
5:16 pm - 11:39 pm
DSM
-
STL
6h 23m1 stop
$340Delta
Sun, Jan 4 - Sun, Jan 11
American Airlines Logo
6:00 am - 2:53 pm
STL
-
DSM
8h 53m1 stop
American Airlines Logo
6:52 pm - 11:44 pm
DSM
-
STL
4h 52m1 stop
$428American Airlines
Thu, Dec 25 - Mon, Dec 29
Delta Logo
6:35 am - 3:41 pm
STL
-
DSM
9h 06m2 stops
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
$464Delta
Thu, Feb 5 - Fri, Feb 6
Multiple Airlines Logo
9:50 am - 7:41 am
STL
-
DSM
21h 51m2 stops
Multiple Airlines Logo
12:15 pm - 10:33 pm
DSM
-
STL
10h 18m1 stop
$473Multiple Airlines
Tue, Dec 23 - Thu, Dec 25

Delta flights from St. Louis to Des Moines

Our best Delta deals on St. Louis to Des Moines flight tickets
Delta
Jan 8
STL6:10 amLambert-St Louis
4h 09m
1 stop
DSM10:19 amDes Moines
Jan 15
DSM10:59 amDes Moines
9h 44m
2 stops
STL8:43 pmLambert-St Louis
$305
Find similar
Delta
Jan 4
STL6:05 amLambert-St Louis
5h 23m
1 stop
DSM11:28 amDes Moines
Jan 11
DSM5:16 pmDes Moines
6h 23m
1 stop
STL11:39 pmLambert-St Louis
$340
Find similar
Delta
Feb 5
STL6:35 amLambert-St Louis
9h 06m
2 stops
DSM3:41 pmDes Moines
Feb 6
DSM10:59 amDes Moines
9h 44m
2 stops
STL8:43 pmLambert-St Louis
$464
Find similar

American Airlines flights from St. Louis to Des Moines

Our best American Airlines deals on St. Louis to Des Moines flight tickets
American Airlines
Jan 8
STL3:37 pmLambert-St Louis
7h 46m
1 stop
DSM11:23 pmDes Moines
Jan 15
DSM5:51 pmDes Moines
5h 04m
1 stop
STL10:55 pmLambert-St Louis
$181
Find similar
American Airlines
Feb 5
STL3:37 pmLambert-St Louis
7h 46m
1 stop
DSM11:23 pmDes Moines
Feb 6
DSM5:01 pmDes Moines
4h 14m
1 stop
STL9:15 pmLambert-St Louis
$255
Find similar
American Airlines
Dec 25
STL6:00 amLambert-St Louis
8h 53m
1 stop
DSM2:53 pmDes Moines
Dec 29
DSM6:52 pmDes Moines
4h 52m
1 stop
STL11:44 pmLambert-St Louis
$428
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 1/8

3:37 pm-11:23 pm

1 stop7h 46m

Des Moines

Thu 1/15

5:51 pm-10:55 pm

1 stop5h 04m

$181

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 1/21

8:05 am-2:33 pm

1 stop6h 28m

Des Moines

Sat 1/24

7:50 am-12:29 pm

1 stop4h 39m

$241

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 2/5

9:10 pm-10:15 pm

Nonstop1h 05m

Des Moines

Fri 2/6

11:30 am-8:15 pm

1 stop8h 45m

$250

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 2/5

3:37 pm-11:23 pm

1 stop7h 46m

Des Moines

Fri 2/6

5:01 pm-9:15 pm

1 stop4h 14m

$255

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 1/8

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Thu 1/15

10:59 am-8:43 pm

2 stops9h 44m

$305

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 2/5

12:20 pm-9:20 pm

2 stops9h 00m

Des Moines

Fri 2/6

11:30 am-8:15 pm

1 stop8h 45m

$334

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 1/4

6:05 am-11:28 am

1 stop5h 23m

Des Moines

Sun 1/11

5:16 pm-11:39 pm

1 stop6h 23m

$340

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 12/25

6:00 am-2:53 pm

1 stop8h 53m

Des Moines

Mon 12/29

6:52 pm-11:44 pm

1 stop4h 52m

$428

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 2/5

6:35 am-3:41 pm

2 stops9h 06m

Des Moines

Fri 2/6

10:59 am-8:43 pm

2 stops9h 44m

$464

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 12/23

9:50 am-7:41 am

2 stops21h 51m

Des Moines

Thu 12/25

12:15 pm-10:33 pm

1 stop10h 18m

$473

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from St. Louis to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from St. Louis to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $381. Flights from St. Louis to Des Moines on a Sunday will generally be more expensive and average around $519. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from St. Louis to Des Moines in the evening for as low as $127. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $484. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Lambert-St Louis - Des Moines flight prices

What cabin class options are available on Lambert-St Louis to Des Moines flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Des Moines flights?

No. A direct flight is the cheapest option for a flight between St. Louis to Des Moines.

When to book flights from St. Louis to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Des Moines (STL to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Des Moines

Fastest flight time

1h 10m

Direct flights

Mon, Tue, Wed, Thu, Fri and Sat

Airports in Des Moines

1 airport
The fastest flight from St. Louis to Des Moines takes 1h 10m
Direct flights go from St. Louis to Des Moines on Monday, Tuesday, Wednesday, Thursday, Friday and Saturday. There are no airlines offering direct flights.
There is 1 airport in Des Moines. From St. Louis there are direct flights to Des Moines (DSM).
Search flight deals

  • How far is Lambert-St Louis to Des Moines by plane?

    A flight from Lambert-St Louis to Des Moines will travel around 273.0 mi. 1h 10m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Des Moines Airport?

    Prices for flights from Lambert-St Louis Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Des Moines Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Des Moines?

  • What is the most popular airline from St. Louis to Des Moines?

Best airlines flying from St. Louis to Des Moines

Compare and see reviews for airlines that fly from St. Louis to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
7.9
4,253 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Des Moines

    Southwest operates around 8 flights from St. Louis to Des Moines every week. The average price of these flights found in the last 72 hours has been $309, but momondo users have found Southwest deals from St. Louis to Des Moines from as low as $77 round-trip. Southwest has been scored 7.9/10 in 4,253 reviews.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Des Moines?

Finding the right flight to Des Moines from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from St. Louis to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Des Moines?

Once you have performed a search for St. Louis to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Des Moines right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Des Moines from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 1/10
Sat 1/17
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States