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Cheap flights from St. Louis to Des Moines from $59

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Des Moines departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:46 am - 10:26 am
STL
-
DSM
4h 40m
1 stop
American Airlines Logo
5:01 pm - 11:46 pm
DSM
-
STL
6h 45m
1 stop
$189American Airlines
Fri, Apr 24 - Mon, Apr 27
United Airlines Logo
7:41 am - 2:27 pm
STL
-
DSM
6h 46m
1 stop
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
$205United Airlines
Tue, Feb 24 - Sat, Feb 28
Delta Logo
10:14 am - 9:20 pm
STL
-
DSM
11h 06m
2 stops
Delta Logo
10:57 am - 2:54 pm
DSM
-
STL
3h 57m
1 stop
$210Delta
Tue, Feb 24 - Sat, Feb 28
Delta Logo
6:00 am - 11:05 am
STL
-
DSM
5h 05m
1 stop
Delta Logo
6:10 am - 1:05 pm
DSM
-
STL
6h 55m
1 stop
$220Delta
Sun, Apr 19 - Wed, Apr 22
United Airlines Logo
7:41 am - 2:32 pm
STL
-
DSM
6h 51m
1 stop
United Airlines Logo
3:28 pm - 9:07 pm
DSM
-
STL
5h 39m
1 stop
$221United Airlines
Sun, Mar 8 - Mon, Mar 9
Delta Logo
10:14 am - 9:20 pm
STL
-
DSM
11h 06m
2 stops
Delta Logo
10:57 am - 8:43 pm
DSM
-
STL
9h 46m
2 stops
$252Delta
Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
7:41 am - 2:27 pm
STL
-
DSM
6h 46m
1 stop
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
$253United Airlines
Wed, Feb 25 - Sat, Feb 28
Southwest Logo
1:15 pm - 11:20 pm
STL
-
DSM
10h 05m
2 stops
Southwest Logo
6:30 pm - 11:10 pm
DSM
-
STL
4h 40m
1 stop
$255Southwest
Sun, Apr 19 - Wed, Apr 22
United Airlines Logo
6:00 am - 10:21 am
STL
-
DSM
4h 21m
1 stop
United Airlines Logo
6:00 am - 10:34 am
DSM
-
STL
4h 34m
1 stop
$257United Airlines
Thu, May 21 - Sun, May 24
United Airlines Logo
6:00 pm - 11:43 pm
STL
-
DSM
5h 43m
1 stop
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
$265United Airlines
Wed, Feb 25 - Sat, Feb 28

American Airlines flights from St. Louis to Des Moines

Our best American Airlines deals on St. Louis to Des Moines flight tickets
American Airlines
Apr 24
STL5:46 amLambert-St Louis
4h 40m
1 stop
DSM10:26 amDes Moines
Apr 27
DSM5:01 pmDes Moines
6h 45m
1 stop
STL11:46 pmLambert-St Louis
$189
American Airlines
Feb 11
STL9:25 amLambert-St Louis
5h 50m
1 stop
DSM3:15 pmDes Moines
Feb 12
DSM5:00 amDes Moines
3h 41m
1 stop
STL8:41 amLambert-St Louis
$409

Southwest flights from St. Louis to Des Moines

Our best Southwest deals on St. Louis to Des Moines flight tickets
Southwest
Apr 19
STL1:15 pmLambert-St Louis
10h 05m
2 stops
DSM11:20 pmDes Moines
Apr 22
DSM6:30 pmDes Moines
4h 40m
1 stop
STL11:10 pmLambert-St Louis
$255
Southwest
Mar 8
STL5:20 amLambert-St Louis
6h 10m
1 stop
DSM11:30 amDes Moines
Mar 9
DSM4:20 pmDes Moines
7h 45m
2 stops
STL12:05 amLambert-St Louis
$275
Southwest
Apr 24
STL8:25 amLambert-St Louis
4h 50m
1 stop
DSM1:15 pmDes Moines
Apr 27
DSM5:25 amDes Moines
9h 30m
2 stops
STL2:55 pmLambert-St Louis
$289

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 4/24

5:46 am-10:26 am

1 stop4h 40m

Des Moines

Mon 4/27

5:01 pm-11:46 pm

1 stop6h 45m

$189

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 2/24

7:41 am-2:27 pm

1 stop6h 46m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$205

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 2/24

10:14 am-9:20 pm

2 stops11h 06m

Des Moines

Sat 2/28

10:57 am-2:54 pm

1 stop3h 57m

$210

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 4/19

6:00 am-11:05 am

1 stop5h 05m

Des Moines

Wed 4/22

6:10 am-1:05 pm

1 stop6h 55m

$220

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 3/8

7:41 am-2:32 pm

1 stop6h 51m

Des Moines

Mon 3/9

3:28 pm-9:07 pm

1 stop5h 39m

$221

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 2/24

10:14 am-9:20 pm

2 stops11h 06m

Des Moines

Sat 2/28

10:57 am-8:43 pm

2 stops9h 46m

$252

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 2/25

7:41 am-2:27 pm

1 stop6h 46m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$253

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 4/19

1:15 pm-11:20 pm

2 stops10h 05m

Des Moines

Wed 4/22

6:30 pm-11:10 pm

1 stop4h 40m

$255

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 5/21

6:00 am-10:21 am

1 stop4h 21m

Des Moines

Sun 5/24

6:00 am-10:34 am

1 stop4h 34m

$257

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 2/25

6:00 pm-11:43 pm

1 stop5h 43m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$265

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from St. Louis to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from St. Louis to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $338. Flights from St. Louis to Des Moines on a Sunday will generally be more expensive and average around $680. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from St. Louis to Des Moines in the evening for as low as $171. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $468. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Lambert-St Louis - Des Moines flight prices

What cabin class options are available on Lambert-St Louis to Des Moines flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Des Moines flights?

You could potentially save up to 78% on your flight if you consider stops on a St. Louis to Des Moines flight.

When to book flights from St. Louis to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Des Moines (STL to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Des Moines

Best Price Found

$194

Fastest flight time

1h 10m

Direct flights

Mon and Sun

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from St. Louis in the past 72 hours is $194. The best round-trip flight deal from St. Louis to Des Moines found on momondo in the last 72 hours is $467.
The fastest flight from St. Louis to Des Moines takes 1h 10m
Direct flights go from St. Louis to Des Moines on Monday and Sunday. The only airline offering direct flights is Southwest.
There is 1 airport in Des Moines. From St. Louis there are direct flights to Des Moines (DSM).
Search flight deals

  • How far is Lambert-St Louis to Des Moines by plane?

    A flight from Lambert-St Louis to Des Moines will travel around 273.0 mi. 1h 10m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Des Moines Airport?

    Prices for flights from Lambert-St Louis Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Des Moines Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Des Moines?

  • What is the most popular airline from St. Louis to Des Moines?

Best airlines flying from St. Louis to Des Moines

Compare and see reviews for airlines that fly from St. Louis to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,280 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Des Moines

    Southwest operates around 8 flights from St. Louis to Des Moines every week. The average price of these flights found in the last 72 hours has been $309, but momondo users have found Southwest deals from St. Louis to Des Moines from as low as $77 round-trip. Southwest has been scored 8.0/10 in 4,280 reviews.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Des Moines?

Finding the right flight to Des Moines from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from St. Louis to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Des Moines?

Once you have performed a search for St. Louis to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Des Moines right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Des Moines from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Des Moines trip

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