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Cheap flights from South Carolina to Columbus from $345

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Columbus departing on 4/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Find the cheapest flights from South Carolina to Columbus

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:16 pm - 9:33 pm
GSP
-
GTR
5h 17m
1 stop
Delta Logo
6:00 am - 12:13 pm
GTR
-
GSP
5h 13m
1 stop
$346Delta
Sat, Jul 4 - Wed, Jul 8
American Airlines Logo
5:15 am - 3:13 pm
GSP
-
GTR
10h 58m
2 stops
American Airlines Logo
3:45 pm - 11:17 pm
GTR
-
GSP
6h 32m
1 stop
$352American Airlines
Sat, Jul 4 - Wed, Jul 8
Delta Logo
8:01 am - 1:32 pm
CLT
-
GTR
6h 31m
1 stop
Delta Logo
2:27 pm - 10:00 pm
GTR
-
CLT
6h 33m
1 stop
$356Delta
Fri, Jun 5 - Mon, Jun 8
American Airlines Logo
7:36 am - 3:13 pm
CLT
-
GTR
8h 37m
1 stop
American Airlines Logo
3:45 pm - 7:55 am
GTR
-
CLT
15h 10m
2 stops
$396American Airlines
Sat, Jun 6 - Mon, Jun 8
American Airlines Logo
11:17 pm - 3:13 pm
CLT
-
GTR
16h 56m
2 stops
American Airlines Logo
3:45 pm - 10:35 pm
GTR
-
CLT
5h 50m
1 stop
$440American Airlines
Fri, Jun 5 - Mon, Jun 8
American Airlines Logo
11:17 pm - 3:13 pm
CLT
-
GTR
16h 56m
2 stops
American Airlines Logo
3:45 pm - 7:55 am
GTR
-
CLT
15h 10m
2 stops
$479American Airlines
Fri, Jun 5 - Mon, Jun 8
American Airlines Logo
11:17 pm - 3:13 pm
CLT
-
GTR
16h 56m
2 stops
American Airlines Logo
3:45 pm - 7:55 am
GTR
-
CLT
15h 10m
2 stops
$523American Airlines
Sat, Jun 6 - Mon, Jun 8
Delta Logo
4:46 pm - 9:37 pm
CLT
-
GTR
5h 51m
1 stop
Delta Logo
6:00 am - 11:05 am
GTR
-
CLT
4h 05m
1 stop
$544Delta
Mon, May 18 - Thu, May 21
American Airlines Logo
7:55 am - 3:27 pm
CLT
-
GTR
8h 32m
1 stop
American Airlines Logo
3:45 pm - 12:53 am
GTR
-
CLT
8h 08m
1 stop
$596American Airlines
Thu, May 14 - Thu, May 21
Delta Logo
4:16 pm - 9:33 pm
MYR
-
GTR
6h 17m
1 stop
Delta Logo
2:27 pm - 7:07 pm
GTR
-
MYR
3h 40m
1 stop
$606Delta
Fri, Jun 19 - Sun, Jun 21

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Delta flights from South Carolina to Columbus, Mississippi

Our best Delta deals on South Carolina to Columbus, Mississippi flight tickets
Delta
Jun 5
CLT8:01 amCharlotte Douglas
6h 31m
1 stop
GTR1:32 pmColumbus Golden Triangle Reg.
Jun 8
GTR2:27 pmColumbus Golden Triangle Reg.
6h 33m
1 stop
CLT10:00 pmCharlotte Douglas
$356
Delta
May 18
CLT4:46 pmCharlotte Douglas
5h 51m
1 stop
GTR9:37 pmColumbus Golden Triangle Reg.
May 21
GTR6:00 amColumbus Golden Triangle Reg.
4h 05m
1 stop
CLT11:05 amCharlotte Douglas
$544
Delta
Jun 19
MYR4:16 pmMyrtle Beach Intl
6h 17m
1 stop
GTR9:33 pmColumbus Golden Triangle Reg.
Jun 21
GTR2:27 pmColumbus Golden Triangle Reg.
3h 40m
1 stop
MYR7:07 pmMyrtle Beach Intl
$606

American Airlines flights from South Carolina to Columbus, Mississippi

Our best American Airlines deals on South Carolina to Columbus, Mississippi flight tickets
American Airlines
Jun 6
CLT7:36 amCharlotte Douglas
8h 37m
1 stop
GTR3:13 pmColumbus Golden Triangle Reg.
Jun 8
GTR3:45 pmColumbus Golden Triangle Reg.
15h 10m
2 stops
CLT7:55 amCharlotte Douglas
$396
American Airlines
Jun 5
CLT11:17 pmCharlotte Douglas
16h 56m
2 stops
GTR3:13 pmColumbus Golden Triangle Reg.
Jun 8
GTR3:45 pmColumbus Golden Triangle Reg.
5h 50m
1 stop
CLT10:35 pmCharlotte Douglas
$440
American Airlines
Jun 5
CLT11:17 pmCharlotte Douglas
16h 56m
2 stops
GTR3:13 pmColumbus Golden Triangle Reg.
Jun 8
GTR3:45 pmColumbus Golden Triangle Reg.
15h 10m
2 stops
CLT7:55 amCharlotte Douglas
$479

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Columbus, Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from South Carolina to Columbus, Mississippi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleColumbus

GSP - GTR

GSPGTR

Greenville

Sat 7/4

5:16 pm-9:33 pm

1 stop5h 17m

Columbus Golden Triangle Reg.

Wed 7/8

6:00 am-12:13 pm

1 stop5h 13m

$346

GreenvilleColumbus

GSP - GTR

GSPGTR

Greenville

Sat 7/4

5:15 am-3:13 pm

2 stops10h 58m

Columbus Golden Triangle Reg.

Wed 7/8

3:45 pm-11:17 pm

1 stop6h 32m

$352

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Fri 6/5

8:01 am-1:32 pm

1 stop6h 31m

Columbus Golden Triangle Reg.

Mon 6/8

2:27 pm-10:00 pm

1 stop6h 33m

$356

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Sat 6/6

7:36 am-3:13 pm

1 stop8h 37m

Columbus Golden Triangle Reg.

Mon 6/8

3:45 pm-7:55 am

2 stops15h 10m

$396

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Fri 6/5

11:17 pm-3:13 pm

2 stops16h 56m

Columbus Golden Triangle Reg.

Mon 6/8

3:45 pm-10:35 pm

1 stop5h 50m

$440

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Fri 6/5

11:17 pm-3:13 pm

2 stops16h 56m

Columbus Golden Triangle Reg.

Mon 6/8

3:45 pm-7:55 am

2 stops15h 10m

$479

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Sat 6/6

11:17 pm-3:13 pm

2 stops16h 56m

Columbus Golden Triangle Reg.

Mon 6/8

3:45 pm-7:55 am

2 stops15h 10m

$523
Quickest round-trip

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Mon 5/18

4:46 pm-9:37 pm

1 stop5h 51m

Columbus Golden Triangle Reg.

Thu 5/21

6:00 am-11:05 am

1 stop4h 05m

$544

CharlotteColumbus

CLT - GTR

CLTGTR

Charlotte Douglas

Thu 5/14

7:55 am-3:27 pm

1 stop8h 32m

Columbus Golden Triangle Reg.

Thu 5/21

3:45 pm-12:53 am

1 stop8h 08m

$596

Myrtle BeachColumbus

MYR - GTR

MYRGTR

Myrtle Beach Intl

Fri 6/19

4:16 pm-9:33 pm

1 stop6h 17m

Columbus Golden Triangle Reg.

Sun 6/21

2:27 pm-7:07 pm

1 stop3h 40m

$606

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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How to get the cheapest flight ticket from South Carolina to Columbus, Mississippi

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Carolina to Columbus, Mississippi flights?

You could potentially save up to 63% on your flight if you consider stops on a South Carolina to Columbus, Mississippi flight.

Cheap South Carolina to Columbus, Mississippi flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Columbus, Mississippi

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from South Carolina to Columbus, Mississippi takes 5h 17m
There are no direct flights from South Carolina to Columbus, Mississippi. There are no popular flight routes from South Carolina to Columbus, Mississippi.
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Frequently asked questions about flying from South Carolina to Columbus, Mississippi

  • When did momondo last update prices for flights from South Carolina to Columbus Golden Triangle Reg. Airport?

    Prices for flights from South Carolina to Columbus Golden Triangle Reg. Airport are refreshed on a daily basis.

  • How old do you have to be to fly from South Carolina to Columbus Golden Triangle Reg. Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Columbus Golden Triangle Reg. Airport.

  • What documentation or ID do you need to fly to Columbus Golden Triangle Reg. Airport?

    The required travel and health documents for your Columbus Golden Triangle Reg. Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Columbus Golden Triangle Reg. Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Columbus?

Book flights to Columbus if you plan to visit one of these locations
Starkville

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Columbus?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Columbus from South Carolina.

Can I find flights from South Carolina to Columbus with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Columbus flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Columbus?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Columbus from South Carolina.

I’m not ready to book a flight from South Carolina to Columbus right now. Can momondo alert me if prices change?

Price alerts on flights to Columbus from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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