Latest deals
Insights
FAQs
Price Alerts

Cheap flights from South America to Knoxville from $211

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to Knoxville departing on 1/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from South America to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:59 am - 12:41 pm
GYE
-
TYS
11h 42m1 stop
Multiple Airlines Logo
11:27 am - 5:20 pm
TYS
-
GYE
30h 53m2 stops
$441Multiple Airlines
Thu, Feb 19 - Thu, May 7
Multiple Airlines Logo
12:59 am - 8:42 pm
GYE
-
TYS
19h 43m1 stop
Multiple Airlines Logo
11:27 am - 5:20 pm
TYS
-
GYE
30h 53m2 stops
$454Multiple Airlines
Wed, Feb 18 - Sun, May 10
Multiple Airlines Logo
12:59 am - 11:01 am
GYE
-
TYS
10h 02m1 stop
Multiple Airlines Logo
7:40 am - 11:55 pm
TYS
-
GYE
17h 15m2 stops
$522Multiple Airlines
Thu, Mar 5 - Fri, Mar 20
Multiple Airlines Logo
12:59 am - 12:41 pm
GYE
-
TYS
11h 42m1 stop
Multiple Airlines Logo
9:40 pm - 11:01 pm
TYS
-
GYE
26h 21m1 stop
$543Multiple Airlines
Thu, Feb 19 - Thu, May 7
United Airlines Logo
8:28 am - 11:40 pm
GYE
-
TYS
38h 12m2 stops
United Airlines Logo
9:00 am - 11:36 pm
TYS
-
GYE
15h 36m2 stops
$596United Airlines
Mon, May 4 - Tue, May 19
United Airlines Logo
1:35 am - 4:53 pm
UIO
-
TYS
39h 18m2 stops
United Airlines Logo
7:25 pm - 12:30 am
TYS
-
UIO
53h 05m2 stops
$654United Airlines
Fri, Feb 6 - Sat, Feb 14
LATAM Airlines Logo
4:35 am - 11:45 pm
SCL
-
TYS
21h 10m2 stops
LATAM Airlines Logo
6:41 pm - 3:30 pm
TYS
-
SCL
18h 49m2 stops
$715LATAM Airlines
Tue, Jan 20 - Thu, Jan 29
LATAM Airlines Logo
4:35 am - 11:45 pm
SCL
-
TYS
21h 10m2 stops
LATAM Airlines Logo
4:06 pm - 3:30 pm
TYS
-
SCL
21h 24m2 stops
$717LATAM Airlines
Tue, Jan 20 - Thu, Jan 29
American Airlines Logo
10:30 pm - 10:47 pm
SCL
-
TYS
26h 17m1 stop
American Airlines Logo
4:00 pm - 9:00 am
TYS
-
SCL
15h 00m2 stops
$720American Airlines
Wed, Jan 21 - Thu, Jan 29
American Airlines Logo
10:30 pm - 11:34 am
SCL
-
TYS
15h 04m1 stop
American Airlines Logo
4:00 pm - 9:00 am
TYS
-
SCL
15h 00m2 stops
$722American Airlines
Wed, Jan 21 - Thu, Jan 29

American Airlines flights from South America to Knoxville

Our best American Airlines deals on South America to Knoxville flight tickets
American Airlines
Mar 16
GYE6:12 amGuayaquil Jose Joaquin de Olmedo
11h 57m
1 stop
TYS7:09 pmKnoxville McGhee Tyson
Apr 16
TYS7:15 amKnoxville McGhee Tyson
14h 40m
1 stop
GYE8:55 pmGuayaquil Jose Joaquin de Olmedo
$689
Find similar
American Airlines
Feb 19
GYE3:31 pmGuayaquil Jose Joaquin de Olmedo
17h 10m
2 stops
TYS8:41 amKnoxville McGhee Tyson
May 10
TYS8:44 pmKnoxville McGhee Tyson
17h 49m
2 stops
GYE1:33 pmGuayaquil Jose Joaquin de Olmedo
$693
Find similar
American Airlines
Mar 15
GYE2:30 pmGuayaquil Jose Joaquin de Olmedo
27h 39m
1 stop
TYS7:09 pmKnoxville McGhee Tyson
Apr 15
TYS7:15 amKnoxville McGhee Tyson
14h 40m
1 stop
GYE8:55 pmGuayaquil Jose Joaquin de Olmedo
$699
Find similar

United Airlines flights from South America to Knoxville

Our best United Airlines deals on South America to Knoxville flight tickets
United Airlines
May 4
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
38h 12m
2 stops
TYS11:40 pmKnoxville McGhee Tyson
May 19
TYS9:00 amKnoxville McGhee Tyson
15h 36m
2 stops
GYE11:36 pmGuayaquil Jose Joaquin de Olmedo
$596
Find similar
United Airlines
Feb 8
UIO1:35 amQuito Mariscal Sucr
37h 14m
2 stops
TYS2:49 pmKnoxville McGhee Tyson
Feb 16
TYS6:45 amKnoxville McGhee Tyson
41h 45m
2 stops
UIO12:30 amQuito Mariscal Sucr
$624
Find similar
United Airlines
Feb 6
UIO1:35 amQuito Mariscal Sucr
39h 18m
2 stops
TYS4:53 pmKnoxville McGhee Tyson
Feb 14
TYS7:25 pmKnoxville McGhee Tyson
53h 05m
2 stops
UIO12:30 amQuito Mariscal Sucr
$654
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 25, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/19

12:59 am-12:41 pm

1 stop11h 42m

Knoxville McGhee Tyson

Thu 5/7

11:27 am-5:20 pm

2 stops30h 53m

$441

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Sun 5/10

11:27 am-5:20 pm

2 stops30h 53m

$454

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 3/5

12:59 am-11:01 am

1 stop10h 02m

Knoxville McGhee Tyson

Fri 3/20

7:40 am-11:55 pm

2 stops17h 15m

$522

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/19

12:59 am-12:41 pm

1 stop11h 42m

Knoxville McGhee Tyson

Thu 5/7

9:40 pm-11:01 pm

1 stop26h 21m

$543

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 5/4

8:28 am-11:40 pm

2 stops38h 12m

Knoxville McGhee Tyson

Tue 5/19

9:00 am-11:36 pm

2 stops15h 36m

$596

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Fri 2/6

1:35 am-4:53 pm

2 stops39h 18m

Knoxville McGhee Tyson

Sat 2/14

7:25 pm-12:30 am

2 stops53h 05m

$654

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 1/20

4:35 am-11:45 pm

2 stops21h 10m

Knoxville McGhee Tyson

Thu 1/29

6:41 pm-3:30 pm

2 stops18h 49m

$715

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 1/20

4:35 am-11:45 pm

2 stops21h 10m

Knoxville McGhee Tyson

Thu 1/29

4:06 pm-3:30 pm

2 stops21h 24m

$717

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:30 pm-10:47 pm

1 stop26h 17m

Knoxville McGhee Tyson

Thu 1/29

4:00 pm-9:00 am

2 stops15h 00m

$720

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:30 pm-11:34 am

1 stop15h 04m

Knoxville McGhee Tyson

Thu 1/29

4:00 pm-9:00 am

2 stops15h 00m

$722

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from South America to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from South America to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $773. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from South America to Knoxville for around $820.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from South America to Knoxville when you can find flight prices for as low as $796. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $910.

Can stopping save me money on South America to Knoxville flights?

You could potentially save up to 4% on your flight if you consider stops on a South America to Knoxville flight.

Cheap South America to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to Knoxville

Fastest flight time

11h 16m

Direct flights

None
The fastest flight from South America to Knoxville takes 11h 16m
There are no direct flights from South America to Knoxville. There are no popular flight routes from South America to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from South America to Knoxville McGhee Tyson Airport?

    Prices for flights from South America to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South America to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South America to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South America to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South America to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South America to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South America to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from South America with this policy.

How can momondo help me find flights from South America to Knoxville?

momondo helps you find the best flight between South America and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South America to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South America to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 1/24
Sat 1/31
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States