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Cheap flights from South America to Knoxville from $261

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to Knoxville departing on 5/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Find the cheapest flights from South America to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:00 am - 5:30 pm
UIO
-
TYS
34h 30m
3 stops
Multiple Airlines Logo
6:29 pm - 7:05 pm
TYS
-
UIO
25h 36m
3 stops
$584Multiple Airlines
Sun, May 17 - Mon, Aug 17
Multiple Airlines Logo
6:00 am - 5:30 pm
UIO
-
TYS
34h 30m
3 stops
Multiple Airlines Logo
1:07 pm - 6:59 pm
TYS
-
UIO
30h 52m
2 stops
$605Multiple Airlines
Sun, May 17 - Mon, Aug 17
American Airlines Logo
6:00 am - 11:59 pm
GYE
-
TYS
16h 59m
1 stop
American Airlines Logo
6:00 am - 10:37 pm
TYS
-
GYE
17h 37m
1 stop
$790American Airlines
Wed, May 27 - Wed, Jul 8
United Airlines Logo
7:25 am - 10:49 am
UIO
-
TYS
26h 24m
2 stops
United Airlines Logo
6:30 am - 5:00 am
TYS
-
UIO
23h 30m
2 stops
$790United Airlines
Sun, May 17 - Mon, Aug 17
American Airlines Logo
6:00 am - 9:58 pm
GYE
-
TYS
14h 58m
2 stops
American Airlines Logo
6:00 am - 10:37 pm
TYS
-
GYE
17h 37m
2 stops
$795American Airlines
Wed, May 27 - Wed, Jul 8
Delta Logo
8:40 pm - 2:48 pm
SCL
-
TYS
18h 08m
1 stop
Delta Logo
8:47 am - 5:35 am
TYS
-
SCL
20h 48m
2 stops
$966Delta
Tue, Aug 4 - Tue, Aug 11
LATAM Airlines Logo
5:40 am - 11:52 pm
SCL
-
TYS
18h 12m
2 stops
LATAM Airlines Logo
4:00 pm - 1:25 pm
TYS
-
SCL
21h 25m
3 stops
$1,011LATAM Airlines
Tue, Aug 4 - Tue, Aug 11
LATAM Airlines Logo
8:40 pm - 9:36 am
SCL
-
TYS
12h 56m
1 stop
LATAM Airlines Logo
3:54 pm - 7:15 am
TYS
-
SCL
15h 21m
1 stop
$1,175LATAM Airlines
Tue, Jul 28 - Mon, Aug 3
Delta Logo
8:40 pm - 1:16 pm
SCL
-
TYS
16h 36m
1 stop
Delta Logo
10:26 am - 6:55 am
TYS
-
SCL
20h 29m
2 stops
$1,186Delta
Tue, Jul 28 - Mon, Aug 3
United Airlines Logo
11:17 am - 6:11 pm
SCL
-
TYS
30h 54m
2 stops
United Airlines Logo
7:05 am - 5:10 am
TYS
-
SCL
22h 05m
2 stops
$1,428United Airlines
Thu, May 7 - Mon, May 11

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Delta flights from South America to Knoxville

Our best Delta deals on South America to Knoxville flight tickets
Delta
Aug 4
SCL8:40 pmSantiago Arturo Merino Benitez
18h 08m
1 stop
TYS2:48 pmKnoxville McGhee Tyson
Aug 11
TYS8:47 amKnoxville McGhee Tyson
20h 48m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
$966
Delta
Jul 28
SCL8:40 pmSantiago Arturo Merino Benitez
16h 36m
1 stop
TYS1:16 pmKnoxville McGhee Tyson
Aug 3
TYS10:26 amKnoxville McGhee Tyson
20h 29m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$1,186
Delta
May 26
SCL8:40 pmSantiago Arturo Merino Benitez
12h 54m
1 stop
TYS9:34 amKnoxville McGhee Tyson
Jun 2
TYS5:40 amKnoxville McGhee Tyson
25h 35m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
$1,516

American Airlines flights from South America to Knoxville

Our best American Airlines deals on South America to Knoxville flight tickets
American Airlines
May 27
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
16h 59m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Jul 8
TYS6:00 amKnoxville McGhee Tyson
17h 37m
1 stop
GYE10:37 pmGuayaquil Jose Joaquin de Olmedo
$790
American Airlines
May 27
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
19h 17m
2 stops
TYS10:48 amKnoxville McGhee Tyson
Jul 8
TYS5:03 amKnoxville McGhee Tyson
18h 34m
2 stops
GYE10:37 pmGuayaquil Jose Joaquin de Olmedo
$795
American Airlines
May 14
UIO7:05 amQuito Mariscal Sucr
15h 54m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Aug 15
TYS6:00 amKnoxville McGhee Tyson
16h 00m
1 stop
UIO9:00 pmQuito Mariscal Sucr
$818

momondo Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 5/17

6:00 am-5:30 pm

3 stops34h 30m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-7:05 pm

3 stops25h 36m

$584

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 5/17

6:00 am-5:30 pm

3 stops34h 30m

Knoxville McGhee Tyson

Mon 8/17

1:07 pm-6:59 pm

2 stops30h 52m

$605

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 5/27

6:00 am-11:59 pm

1 stop16h 59m

Knoxville McGhee Tyson

Wed 7/8

6:00 am-10:37 pm

1 stop17h 37m

$790

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 5/17

7:25 am-10:49 am

2 stops26h 24m

Knoxville McGhee Tyson

Mon 8/17

6:30 am-5:00 am

2 stops23h 30m

$790

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 5/27

6:00 am-9:58 pm

2 stops14h 58m

Knoxville McGhee Tyson

Wed 7/8

6:00 am-10:37 pm

2 stops17h 37m

$795

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 8/4

8:40 pm-2:48 pm

1 stop18h 08m

Knoxville McGhee Tyson

Tue 8/11

8:47 am-5:35 am

2 stops20h 48m

$966

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 8/4

5:40 am-11:52 pm

2 stops18h 12m

Knoxville McGhee Tyson

Tue 8/11

4:00 pm-1:25 pm

3 stops21h 25m

$1,011
Quickest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 7/28

8:40 pm-9:36 am

1 stop12h 56m

Knoxville McGhee Tyson

Mon 8/3

3:54 pm-7:15 am

1 stop15h 21m

$1,175

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 7/28

8:40 pm-1:16 pm

1 stop16h 36m

Knoxville McGhee Tyson

Mon 8/3

10:26 am-6:55 am

2 stops20h 29m

$1,186

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 5/7

11:17 am-6:11 pm

2 stops30h 54m

Knoxville McGhee Tyson

Mon 5/11

7:05 am-5:10 am

2 stops22h 05m

$1,428

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South America to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South America to Knoxville flights?

You could potentially save up to 1% on your flight if you consider stops on a South America to Knoxville flight.

Cheap South America to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to Knoxville

Fastest flight time

8h 28m

Direct flights

None
The fastest flight from South America to Knoxville takes 8h 28m
There are no direct flights from South America to Knoxville. There are no popular flight routes from South America to Knoxville.
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Frequently asked questions about flying from South America to Knoxville

  • When did momondo last update prices for flights from South America to Knoxville McGhee Tyson Airport?

    Prices for flights from South America to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South America to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South America to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South America to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South America to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South America to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South America to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from South America with this policy.

How can momondo help me find flights from South America to Knoxville?

momondo helps you find the best flight between South America and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South America to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South America to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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