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Cheap flights from South America to Knoxville from $250

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to Knoxville departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South America to Knoxville

Cheap round-trip flights

United Airlines Logo
8:32 am - 6:10 pmGYE-TYS
32h 38m2 stops
United Airlines Logo
9:10 am - 1:32 pmTYS-GYE
29h 22m2 stops
$596United Airlines
Find Deal
Mon, Sep 15 - Wed, Oct 29
Logo
3:30 am - 8:09 pmGYE-TYS
16h 39m2 stops
Logo
11:42 am - 11:25 amTYS-GYE
23h 43m2 stops
$622
Find Deal
Sun, Nov 2 - Mon, Dec 8
American Airlines Logo
8:15 am - 11:29 amGYE-TYS
26h 14m2 stops
American Airlines Logo
7:20 pm - 10:40 pmTYS-GYE
27h 20m2 stops
$705American Airlines
Find Deal
Mon, Oct 20 - Mon, Nov 10
American Airlines Logo
8:15 am - 9:52 amGYE-TYS
24h 37m2 stops
American Airlines Logo
7:20 pm - 10:40 pmTYS-GYE
27h 20m2 stops
$706American Airlines
Find Deal
Mon, Oct 20 - Mon, Nov 10
Delta Logo
9:40 pm - 2:43 pmSCL-TYS
18h 03m1 stop
Delta Logo
5:16 pm - 2:25 pmTYS-SCL
20h 09m2 stops
$725Delta
Find Deal
Mon, Oct 20 - Mon, Oct 27
LATAM Airlines Logo
12:25 am - 11:46 pmSCL-TYS
24h 21m2 stops
LATAM Airlines Logo
5:16 pm - 7:40 amTYS-SCL
13h 24m1 stop
$734LATAM Airlines
Find Deal
Sun, Oct 19 - Mon, Oct 27
LATAM Airlines Logo
12:25 am - 11:46 pmSCL-TYS
24h 21m2 stops
LATAM Airlines Logo
5:16 pm - 7:40 amTYS-SCL
13h 24m1 stop
$735LATAM Airlines
Find Deal
Sun, Oct 19 - Mon, Oct 27
Delta Logo
8:40 pm - 11:22 pmGYE-TYS
26h 42m2 stops
Delta Logo
4:00 pm - 2:05 amTYS-GYE
34h 05m2 stops
$743Delta
Find Deal
Mon, Nov 3 - Tue, Dec 9
Avianca Logo
3:15 am - 10:28 amGYE-TYS
30h 13m2 stops
Avianca Logo
5:45 am - 2:15 amTYS-GYE
21h 30m2 stops
$793Avianca
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Fri, Sep 12 - Tue, Oct 28
Avianca Logo
2:50 pm - 10:28 amGYE-TYS
42h 38m2 stops
Avianca Logo
5:45 am - 2:15 amTYS-GYE
21h 30m2 stops
$830Avianca
Find Deal
Mon, Sep 15 - Thu, Oct 30

LATAM Airlines flights from South America to Knoxville

Our best LATAM Airlines deals on South America to Knoxville flight tickets
LATAM Airlines
Oct 19
SCL12:25 amSantiago Arturo Merino Benitez
24h 21m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
Oct 27
TYS5:16 pmKnoxville McGhee Tyson
13h 24m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$734
Find similar
LATAM Airlines
Oct 19
SCL12:25 amSantiago Arturo Merino Benitez
24h 21m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
Oct 27
TYS5:16 pmKnoxville McGhee Tyson
13h 24m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$735
Find similar
LATAM Airlines
Oct 20
SCL12:25 amSantiago Arturo Merino Benitez
23h 42m
2 stops
TYS11:07 pmKnoxville McGhee Tyson
Oct 26
TYS5:28 pmKnoxville McGhee Tyson
13h 12m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$774
Find similar

Delta flights from South America to Knoxville

Our best Delta deals on South America to Knoxville flight tickets
Delta
Oct 20
SCL9:40 pmSantiago Arturo Merino Benitez
18h 03m
1 stop
TYS2:43 pmKnoxville McGhee Tyson
Oct 27
TYS5:16 pmKnoxville McGhee Tyson
20h 09m
2 stops
SCL2:25 pmSantiago Arturo Merino Benitez
$725
Find similar
Delta
Nov 3
GYE8:40 pmGuayaquil Jose Joaquin de Olmedo
26h 42m
2 stops
TYS11:22 pmKnoxville McGhee Tyson
Dec 9
TYS4:00 pmKnoxville McGhee Tyson
34h 05m
2 stops
GYE2:05 amGuayaquil Jose Joaquin de Olmedo
$743
Find similar
Delta
Oct 21
SCL9:40 pmSantiago Arturo Merino Benitez
18h 03m
1 stop
TYS2:43 pmKnoxville McGhee Tyson
Oct 26
TYS11:40 amKnoxville McGhee Tyson
19h 00m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$765
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 9/15

8:32 am-6:10 pm

2 stops32h 38m

Knoxville McGhee Tyson

Wed 10/29

9:10 am-1:32 pm

2 stops29h 22m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 11/2

3:30 am-8:09 pm

2 stops16h 39m

Knoxville McGhee Tyson

Mon 12/8

11:42 am-11:25 am

2 stops23h 43m

$622

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 10/20

8:15 am-11:29 am

2 stops26h 14m

Knoxville McGhee Tyson

Mon 11/10

7:20 pm-10:40 pm

2 stops27h 20m

$705

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 10/20

8:15 am-9:52 am

2 stops24h 37m

Knoxville McGhee Tyson

Mon 11/10

7:20 pm-10:40 pm

2 stops27h 20m

$706

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 10/20

9:40 pm-2:43 pm

1 stop18h 03m

Knoxville McGhee Tyson

Mon 10/27

5:16 pm-2:25 pm

2 stops20h 09m

$725

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 10/19

12:25 am-11:46 pm

2 stops24h 21m

Knoxville McGhee Tyson

Mon 10/27

5:16 pm-7:40 am

1 stop13h 24m

$734

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 10/19

12:25 am-11:46 pm

2 stops24h 21m

Knoxville McGhee Tyson

Mon 10/27

5:16 pm-7:40 am

1 stop13h 24m

$735

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 11/3

8:40 pm-11:22 pm

2 stops26h 42m

Knoxville McGhee Tyson

Tue 12/9

4:00 pm-2:05 am

2 stops34h 05m

$743

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 9/12

3:15 am-10:28 am

2 stops30h 13m

Knoxville McGhee Tyson

Tue 10/28

5:45 am-2:15 am

2 stops21h 30m

$793

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 9/15

2:50 pm-10:28 am

2 stops42h 38m

Knoxville McGhee Tyson

Thu 10/30

5:45 am-2:15 am

2 stops21h 30m

$830

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South America to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from South America to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $773. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from South America to Knoxville for around $820.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from South America to Knoxville when you can find flight prices for as low as $796. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $910.

Cheap South America to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to Knoxville

Direct flights

None
There are no direct flights from South America to Knoxville. There are no popular flight routes from South America to Knoxville.
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  • When did momondo last update prices for flights from South America to Knoxville McGhee Tyson Airport?

    Prices for flights from South America to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South America to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South America to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South America to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South America to Knoxville

Compare and see reviews for airlines that fly from South America to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $568Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South America to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South America to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South America to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from South America with this policy.

How can momondo help me find flights from South America to Knoxville?

momondo helps you find the best flight between South America and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South America to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South America to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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