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Cheap flights from South America to Knoxville from $205

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to Knoxville departing on 3/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South America to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:40 am - 1:15 pm
GYE
-
TYS
31h 35m
2 stops
Multiple Airlines Logo
9:40 pm - 11:04 pm
TYS
-
GYE
26h 24m
1 stop
$459Multiple Airlines
Tue, Mar 10 - Thu, May 7
Multiple Airlines Logo
11:59 pm - 10:10 am
GYE
-
TYS
9h 11m
1 stop
Multiple Airlines Logo
9:40 pm - 11:04 pm
TYS
-
GYE
26h 24m
1 stop
$475Multiple Airlines
Tue, Mar 10 - Thu, May 7
United Airlines Logo
12:35 am - 5:04 pm
UIO
-
TYS
39h 29m
2 stops
United Airlines Logo
7:05 am - 11:25 pm
TYS
-
UIO
17h 20m
1 stop
$767United Airlines
Wed, Apr 29 - Mon, May 4
American Airlines Logo
6:30 am - 11:59 pm
UIO
-
TYS
16h 29m
1 stop
American Airlines Logo
6:00 am - 10:10 pm
TYS
-
UIO
17h 10m
1 stop
$768American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
6:30 am - 11:20 pm
UIO
-
TYS
15h 50m
2 stops
American Airlines Logo
6:00 am - 10:10 pm
TYS
-
UIO
17h 10m
1 stop
$773American Airlines
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
12:35 am - 5:04 pm
UIO
-
TYS
39h 29m
2 stops
United Airlines Logo
5:56 pm - 11:25 pm
TYS
-
UIO
30h 29m
2 stops
$775United Airlines
Wed, Apr 29 - Mon, May 4
LATAM Airlines Logo
6:50 pm - 11:06 am
UIO
-
TYS
15h 16m
2 stops
LATAM Airlines Logo
4:00 pm - 4:43 am
TYS
-
UIO
13h 43m
2 stops
$788LATAM Airlines
Mon, Jun 29 - Fri, Sep 4
LATAM Airlines Logo
8:40 pm - 9:16 am
SCL
-
TYS
12h 36m
1 stop
LATAM Airlines Logo
4:38 pm - 6:55 am
TYS
-
SCL
14h 17m
2 stops
$807LATAM Airlines
Wed, Apr 8 - Wed, Apr 15
Delta Logo
8:40 pm - 4:06 pm
SCL
-
TYS
19h 26m
1 stop
Delta Logo
12:03 pm - 7:15 am
TYS
-
SCL
19h 12m
1 stop
$811Delta
Wed, Apr 8 - Wed, Apr 15
Delta Logo
8:40 pm - 9:11 am
SCL
-
TYS
12h 31m
1 stop
Delta Logo
10:05 am - 6:55 am
TYS
-
SCL
20h 50m
2 stops
$876Delta
Thu, Jul 16 - Thu, Jul 23

United Airlines flights from South America to Knoxville

Our best United Airlines deals on South America to Knoxville flight tickets
United Airlines
Apr 13
GYE12:22 pmGuayaquil Jose Joaquin de Olmedo
28h 53m
2 stops
TYS6:15 pmKnoxville McGhee Tyson
Apr 28
TYS7:05 amKnoxville McGhee Tyson
14h 49m
2 stops
GYE8:54 pmGuayaquil Jose Joaquin de Olmedo
$682
United Airlines
Jun 23
GYE12:21 pmGuayaquil Jose Joaquin de Olmedo
33h 51m
2 stops
TYS11:12 pmKnoxville McGhee Tyson
Aug 12
TYS7:00 amKnoxville McGhee Tyson
14h 53m
2 stops
GYE8:53 pmGuayaquil Jose Joaquin de Olmedo
$734
United Airlines
Jun 21
GYE12:21 pmGuayaquil Jose Joaquin de Olmedo
33h 51m
2 stops
TYS11:12 pmKnoxville McGhee Tyson
Aug 14
TYS7:00 amKnoxville McGhee Tyson
14h 53m
2 stops
GYE8:53 pmGuayaquil Jose Joaquin de Olmedo
$742

American Airlines flights from South America to Knoxville

Our best American Airlines deals on South America to Knoxville flight tickets
American Airlines
May 3
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
8h 28m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 19
TYS6:30 amKnoxville McGhee Tyson
8h 01m
1 stop
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$705
American Airlines
May 3
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
8h 28m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 19
TYS6:30 amKnoxville McGhee Tyson
8h 01m
1 stop
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$706
American Airlines
May 3
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
8h 28m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 19
TYS6:30 amKnoxville McGhee Tyson
8h 01m
1 stop
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$707

momondo Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 3/10

4:40 am-1:15 pm

2 stops31h 35m

Knoxville McGhee Tyson

Thu 5/7

9:40 pm-11:04 pm

1 stop26h 24m

$459

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 3/10

11:59 pm-10:10 am

1 stop9h 11m

Knoxville McGhee Tyson

Thu 5/7

9:40 pm-11:04 pm

1 stop26h 24m

$475

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Wed 4/29

12:35 am-5:04 pm

2 stops39h 29m

Knoxville McGhee Tyson

Mon 5/4

7:05 am-11:25 pm

1 stop17h 20m

$767

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Tue 3/24

6:30 am-11:59 pm

1 stop16h 29m

Knoxville McGhee Tyson

Tue 3/31

6:00 am-10:10 pm

1 stop17h 10m

$768

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Tue 3/24

6:30 am-11:20 pm

2 stops15h 50m

Knoxville McGhee Tyson

Tue 3/31

6:00 am-10:10 pm

1 stop17h 10m

$773

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Wed 4/29

12:35 am-5:04 pm

2 stops39h 29m

Knoxville McGhee Tyson

Mon 5/4

5:56 pm-11:25 pm

2 stops30h 29m

$775

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Mon 6/29

6:50 pm-11:06 am

2 stops15h 16m

Knoxville McGhee Tyson

Fri 9/4

4:00 pm-4:43 am

2 stops13h 43m

$788

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 4/8

8:40 pm-9:16 am

1 stop12h 36m

Knoxville McGhee Tyson

Wed 4/15

4:38 pm-6:55 am

2 stops14h 17m

$807

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 4/8

8:40 pm-4:06 pm

1 stop19h 26m

Knoxville McGhee Tyson

Wed 4/15

12:03 pm-7:15 am

1 stop19h 12m

$811

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/16

8:40 pm-9:11 am

1 stop12h 31m

Knoxville McGhee Tyson

Thu 7/23

10:05 am-6:55 am

2 stops20h 50m

$876

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South America to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South America to Knoxville flights?

You could potentially save up to 1% on your flight if you consider stops on a South America to Knoxville flight.

Cheap South America to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to Knoxville

Fastest flight time

10h 02m

Direct flights

None
The fastest flight from South America to Knoxville takes 10h 02m
There are no direct flights from South America to Knoxville. There are no popular flight routes from South America to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from South America to Knoxville McGhee Tyson Airport?

    Prices for flights from South America to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South America to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South America to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South America to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South America to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South America to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South America to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from South America with this policy.

How can momondo help me find flights from South America to Knoxville?

momondo helps you find the best flight between South America and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South America to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South America to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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