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Cheap flights from South America to Knoxville from $361

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to Knoxville departing on 7/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from South America to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:06 am - 11:14 am
UIO
-
TYS
27h 08m
2 stops
Multiple Airlines Logo
6:00 am - 9:25 pm
TYS
-
UIO
40h 25m
2 stops
$731Multiple Airlines
Sun, Oct 18 - Sun, Oct 25
United Airlines Logo
12:35 am - 9:57 am
UIO
-
TYS
56h 22m
2 stops
United Airlines Logo
7:15 am - 11:25 pm
TYS
-
UIO
17h 10m
1 stop
$740United Airlines
Wed, Sep 16 - Fri, Sep 25
Multiple Airlines Logo
9:00 am - 11:07 pm
UIO
-
TYS
13h 07m
1 stop
Multiple Airlines Logo
6:00 am - 9:25 pm
TYS
-
UIO
40h 25m
2 stops
$745Multiple Airlines
Sun, Oct 18 - Sun, Oct 25
Multiple Airlines Logo
7:06 am - 11:14 am
UIO
-
TYS
27h 08m
2 stops
Multiple Airlines Logo
12:04 pm - 4:58 am
TYS
-
UIO
41h 54m
3 stops
$746Multiple Airlines
Sun, Oct 18 - Mon, Oct 26
American Airlines Logo
8:50 pm - 11:51 pm
SCL
-
TYS
27h 01m
1 stop
American Airlines Logo
6:00 am - 6:25 am
TYS
-
SCL
24h 25m
1 stop
$874American Airlines
Fri, Aug 21 - Tue, Sep 1
American Airlines Logo
8:50 pm - 11:51 pm
SCL
-
TYS
27h 01m
1 stop
American Airlines Logo
12:09 pm - 6:25 am
TYS
-
SCL
18h 16m
2 stops
$878American Airlines
Fri, Aug 21 - Tue, Sep 1
Delta Logo
7:55 pm - 6:44 pm
SCL
-
TYS
22h 49m
2 stops
Delta Logo
11:57 am - 7:15 am
TYS
-
SCL
19h 18m
1 stop
$916Delta
Thu, Jul 9 - Tue, Jul 14
Delta Logo
8:40 pm - 2:48 pm
SCL
-
TYS
18h 08m
1 stop
Delta Logo
6:05 pm - 7:15 am
TYS
-
SCL
13h 10m
1 stop
$938Delta
Thu, Jul 9 - Tue, Jul 14
LATAM Airlines Logo
4:50 pm - 11:52 pm
SCL
-
TYS
31h 02m
2 stops
LATAM Airlines Logo
7:49 pm - 7:15 am
TYS
-
SCL
11h 26m
1 stop
$951LATAM Airlines
Thu, Jul 9 - Thu, Jul 16
LATAM Airlines Logo
9:30 pm - 11:52 pm
SCL
-
TYS
26h 22m
2 stops
LATAM Airlines Logo
3:54 pm - 1:25 pm
TYS
-
SCL
21h 31m
3 stops
$961LATAM Airlines
Thu, Jul 9 - Tue, Jul 14

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United Airlines flights from South America to Knoxville

Our best United Airlines deals on South America to Knoxville flight tickets
United Airlines
Sep 16
UIO12:35 amQuito Mariscal Sucr
56h 22m
2 stops
TYS9:57 amKnoxville McGhee Tyson
Sep 25
TYS7:15 amKnoxville McGhee Tyson
17h 10m
1 stop
UIO11:25 pmQuito Mariscal Sucr
$740
United Airlines
Oct 13
UIO12:35 amQuito Mariscal Sucr
32h 10m
2 stops
TYS9:45 amKnoxville McGhee Tyson
Oct 21
TYS10:42 amKnoxville McGhee Tyson
37h 43m
2 stops
UIO11:25 pmQuito Mariscal Sucr
$774
United Airlines
Sep 16
UIO12:35 amQuito Mariscal Sucr
20h 10m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
Sep 25
TYS7:15 amKnoxville McGhee Tyson
17h 10m
1 stop
UIO11:25 pmQuito Mariscal Sucr
$804

Delta flights from South America to Knoxville

Our best Delta deals on South America to Knoxville flight tickets
Delta
Sep 16
UIO12:59 amQuito Mariscal Sucr
9h 06m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Sep 25
TYS5:45 amKnoxville McGhee Tyson
14h 14m
1 stop
UIO6:59 pmQuito Mariscal Sucr
$833
Delta
Sep 16
UIO12:59 amQuito Mariscal Sucr
13h 26m
1 stop
TYS3:25 pmKnoxville McGhee Tyson
Sep 25
TYS5:45 amKnoxville McGhee Tyson
14h 14m
1 stop
UIO6:59 pmQuito Mariscal Sucr
$845
Delta
Jul 9
SCL7:55 pmSantiago Arturo Merino Benitez
22h 49m
2 stops
TYS6:44 pmKnoxville McGhee Tyson
Jul 14
TYS11:57 amKnoxville McGhee Tyson
19h 18m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
$916

momondo Fare Finder

 
Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 14, 2026.
Use the filters below to find and compare flights from South America to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 10/18

7:06 am-11:14 am

2 stops27h 08m

Knoxville McGhee Tyson

Sun 10/25

6:00 am-9:25 pm

2 stops40h 25m

$731

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Wed 9/16

12:35 am-9:57 am

2 stops56h 22m

Knoxville McGhee Tyson

Fri 9/25

7:15 am-11:25 pm

1 stop17h 10m

$740

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 10/18

9:00 am-11:07 pm

1 stop13h 07m

Knoxville McGhee Tyson

Sun 10/25

6:00 am-9:25 pm

2 stops40h 25m

$745

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

Sun 10/18

7:06 am-11:14 am

2 stops27h 08m

Knoxville McGhee Tyson

Mon 10/26

12:04 pm-4:58 am

3 stops41h 54m

$746

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

8:50 pm-11:51 pm

1 stop27h 01m

Knoxville McGhee Tyson

Tue 9/1

6:00 am-6:25 am

1 stop24h 25m

$874

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

8:50 pm-11:51 pm

1 stop27h 01m

Knoxville McGhee Tyson

Tue 9/1

12:09 pm-6:25 am

2 stops18h 16m

$878

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/9

7:55 pm-6:44 pm

2 stops22h 49m

Knoxville McGhee Tyson

Tue 7/14

11:57 am-7:15 am

1 stop19h 18m

$916
Quickest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/9

8:40 pm-2:48 pm

1 stop18h 08m

Knoxville McGhee Tyson

Tue 7/14

6:05 pm-7:15 am

1 stop13h 10m

$938

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/9

4:50 pm-11:52 pm

2 stops31h 02m

Knoxville McGhee Tyson

Thu 7/16

7:49 pm-7:15 am

1 stop11h 26m

$951

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/9

9:30 pm-11:52 pm

2 stops26h 22m

Knoxville McGhee Tyson

Tue 7/14

3:54 pm-1:25 pm

3 stops21h 31m

$961

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South America to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from South America, with most prices found around $0. If you aren’t able to travel during the month of April, then book flights to Knoxville from South America during March instead. Flights to Knoxville in March, while not as cheap as those in April, still average around $0.

Can stopping save me money on South America to Knoxville flights?

You could potentially save up to 11% on your flight if you consider stops on a South America to Knoxville flight.

Cheap South America to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to Knoxville

Fastest flight time

18h 50m

Direct flights

None
The fastest flight from South America to Knoxville takes 18h 50m
There are no direct flights from South America to Knoxville. There are no popular flight routes from South America to Knoxville.
Search flight deals

Frequently asked questions about flying from South America to Knoxville

  • When did momondo last update prices for flights from South America to Knoxville McGhee Tyson Airport?

    Prices for flights from South America to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South America to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South America to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South America to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South America to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South America to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South America to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from South America with this policy.

How can momondo help me find flights from South America to Knoxville?

momondo helps you find the best flight between South America and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South America to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South America to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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