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Cheap flights from Santo Domingo to Knoxville from $213

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 5/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santo Domingo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:19 am - 8:29 pm
SDQ
-
TYS
34h 10m
2 stops
Multiple Airlines Logo
8:00 am - 9:53 am
TYS
-
SDQ
25h 53m
1 stop
$520Multiple Airlines
Wed, May 27 - Wed, Jun 3
Multiple Airlines Logo
12:41 pm - 10:20 pm
SDQ
-
TYS
33h 39m
2 stops
Multiple Airlines Logo
7:10 am - 2:35 am
TYS
-
SDQ
19h 25m
1 stop
$539Multiple Airlines
Wed, May 13 - Thu, Sep 10
Multiple Airlines Logo
6:30 am - 12:59 pm
SDQ
-
TYS
30h 29m
1 stop
Multiple Airlines Logo
8:00 am - 9:53 am
TYS
-
SDQ
25h 53m
1 stop
$583Multiple Airlines
Wed, May 27 - Wed, Jun 3
American Airlines Logo
10:27 am - 11:59 pm
SDQ
-
TYS
13h 32m
1 stop
American Airlines Logo
6:00 am - 12:57 pm
TYS
-
SDQ
6h 57m
1 stop
$601American Airlines
Wed, Jul 8 - Thu, Jul 16
American Airlines Logo
7:00 am - 9:31 pm
SDQ
-
TYS
14h 31m
2 stops
American Airlines Logo
11:18 am - 10:55 pm
TYS
-
SDQ
11h 37m
2 stops
$606American Airlines
Wed, May 27 - Wed, Jun 3
American Airlines Logo
7:40 pm - 11:45 am
SDQ
-
TYS
16h 05m
2 stops
American Airlines Logo
6:00 am - 6:40 pm
TYS
-
SDQ
12h 40m
2 stops
$659American Airlines
Wed, Jul 8 - Thu, Jul 16
Multiple Airlines Logo
6:10 am - 11:37 pm
SDQ
-
TYS
17h 27m
2 stops
Multiple Airlines Logo
7:10 am - 5:29 am
TYS
-
SDQ
22h 19m
1 stop
$662Multiple Airlines
Mon, May 25 - Sat, May 30
Delta Logo
2:56 pm - 9:45 pm
SDQ
-
TYS
6h 49m
1 stop
Delta Logo
7:30 am - 6:24 pm
TYS
-
SDQ
10h 54m
2 stops
$665Delta
Mon, Oct 26 - Sat, Oct 31
American Airlines Logo
3:40 pm - 11:35 pm
SDQ
-
TYS
7h 55m
1 stop
American Airlines Logo
6:21 am - 1:00 pm
TYS
-
SDQ
6h 39m
1 stop
$684American Airlines
Mon, Oct 26 - Sat, Oct 31
American Airlines Logo
8:00 am - 11:30 pm
SDQ
-
TYS
15h 30m
2 stops
American Airlines Logo
6:08 am - 7:55 pm
TYS
-
SDQ
13h 47m
2 stops
$688American Airlines
Mon, Oct 26 - Sat, Oct 31

American Airlines flights from Santo Domingo to Knoxville

Our best American Airlines deals on Santo Domingo to Knoxville flight tickets
American Airlines
Jul 8
SDQ10:27 amSanto Domingo Las Americas
13h 32m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Jul 16
TYS6:00 amKnoxville McGhee Tyson
6h 57m
1 stop
SDQ12:57 pmSanto Domingo Las Americas
$601
American Airlines
May 27
SDQ7:00 amSanto Domingo Las Americas
14h 31m
2 stops
TYS9:31 pmKnoxville McGhee Tyson
Jun 3
TYS11:18 amKnoxville McGhee Tyson
11h 37m
2 stops
SDQ10:55 pmSanto Domingo Las Americas
$606
American Airlines
Jul 8
SDQ7:40 pmSanto Domingo Las Americas
16h 05m
2 stops
TYS11:45 amKnoxville McGhee Tyson
Jul 16
TYS6:00 amKnoxville McGhee Tyson
12h 40m
2 stops
SDQ6:40 pmSanto Domingo Las Americas
$659

United Airlines flights from Santo Domingo to Knoxville

Our best United Airlines deals on Santo Domingo to Knoxville flight tickets
United Airlines
May 30
SDQ6:00 amSanto Domingo Las Americas
17h 54m
2 stops
TYS11:54 pmKnoxville McGhee Tyson
Jun 2
TYS5:45 amKnoxville McGhee Tyson
17h 01m
2 stops
SDQ10:46 pmSanto Domingo Las Americas
$5,288
United Airlines
May 30
SDQ1:10 pmSanto Domingo Las Americas
10h 44m
2 stops
TYS11:54 pmKnoxville McGhee Tyson
Jun 2
TYS7:19 pmKnoxville McGhee Tyson
18h 51m
2 stops
SDQ2:10 pmSanto Domingo Las Americas
$5,316

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 5/27

10:19 am-8:29 pm

2 stops34h 10m

Knoxville McGhee Tyson

Wed 6/3

8:00 am-9:53 am

1 stop25h 53m

$520

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 5/13

12:41 pm-10:20 pm

2 stops33h 39m

Knoxville McGhee Tyson

Thu 9/10

7:10 am-2:35 am

1 stop19h 25m

$539

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 5/27

6:30 am-12:59 pm

1 stop30h 29m

Knoxville McGhee Tyson

Wed 6/3

8:00 am-9:53 am

1 stop25h 53m

$583

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 7/8

10:27 am-11:59 pm

1 stop13h 32m

Knoxville McGhee Tyson

Thu 7/16

6:00 am-12:57 pm

1 stop6h 57m

$601

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 5/27

7:00 am-9:31 pm

2 stops14h 31m

Knoxville McGhee Tyson

Wed 6/3

11:18 am-10:55 pm

2 stops11h 37m

$606

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 7/8

7:40 pm-11:45 am

2 stops16h 05m

Knoxville McGhee Tyson

Thu 7/16

6:00 am-6:40 pm

2 stops12h 40m

$659

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 5/25

6:10 am-11:37 pm

2 stops17h 27m

Knoxville McGhee Tyson

Sat 5/30

7:10 am-5:29 am

1 stop22h 19m

$662

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 10/26

2:56 pm-9:45 pm

1 stop6h 49m

Knoxville McGhee Tyson

Sat 10/31

7:30 am-6:24 pm

2 stops10h 54m

$665
Quickest round-trip

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 10/26

3:40 pm-11:35 pm

1 stop7h 55m

Knoxville McGhee Tyson

Sat 10/31

6:21 am-1:00 pm

1 stop6h 39m

$684

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 10/26

8:00 am-11:30 pm

2 stops15h 30m

Knoxville McGhee Tyson

Sat 10/31

6:08 am-7:55 pm

2 stops13h 47m

$688

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santo Domingo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Santo Domingo, with most prices found around $0. If you aren’t able to travel during the month of June, then book flights to Knoxville from Santo Domingo during September instead. Flights to Knoxville in September, while not as cheap as those in June, still average around $515.

Can stopping save me money on Santo Domingo to Knoxville flights?

You could potentially save up to 5% on your flight if you consider stops on a Santo Domingo to Knoxville flight.

When to book flights from Santo Domingo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Knoxville (SDQ to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Knoxville

Fastest flight time

6h 49m

Direct flights

None
The fastest flight from Santo Domingo to Knoxville takes 6h 49m
There are no direct flights from Santo Domingo to Knoxville. There are no popular flight routes from Santo Domingo to Knoxville.
Search flight deals

Frequently asked questions about flying from Santo Domingo to Knoxville

  • How far is Santo Domingo Las Americas to Knoxville McGhee Tyson by plane?

    Santo Domingo Las Americas and Knoxville McGhee Tyson are 1477.4 mi apart from one another. In terms of flight time, this usually takes a little over 6h 49m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to Knoxville?

Best airlines flying from Santo Domingo to Knoxville

Compare and see reviews for airlines that fly from Santo Domingo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $513Free CancellationRating
7.9
8,460 reviews
Search Delta flights
American AirlinesPriceFrom $513Free CancellationRating
7.1
11,673 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Knoxville?

It is quick and easy to find Santo Domingo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Santo Domingo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Santo Domingo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santo Domingo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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