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Cheap flights from Santo Domingo to Knoxville from $206

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santo Domingo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:30 pm - 10:42 pmSDQ-TYS
32h 12m2 stops
Multiple Airlines Logo
5:59 pm - 5:50 pmTYS-SDQ
22h 51m1 stop
$422Multiple Airlines
Find Deal
Sat, Dec 20 - Sat, Jan 10
Multiple Airlines Logo
3:59 am - 8:33 pmSDQ-TYS
17h 34m1 stop
Multiple Airlines Logo
5:30 pm - 1:50 amTYS-SDQ
31h 20m2 stops
$434Multiple Airlines
Find Deal
Fri, Dec 19 - Sat, Jan 10
Multiple Airlines Logo
4:23 pm - 8:18 amSDQ-TYS
16h 55m1 stop
Multiple Airlines Logo
5:59 pm - 5:50 pmTYS-SDQ
22h 51m1 stop
$440Multiple Airlines
Find Deal
Sat, Dec 20 - Sat, Jan 10
Multiple Airlines Logo
3:59 am - 8:33 pmSDQ-TYS
17h 34m1 stop
Multiple Airlines Logo
5:59 pm - 5:50 pmTYS-SDQ
22h 51m1 stop
$443Multiple Airlines
Find Deal
Fri, Dec 19 - Sat, Jan 10
Multiple Airlines Logo
3:59 am - 2:44 pmSDQ-TYS
11h 45m1 stop
Multiple Airlines Logo
5:59 pm - 1:39 amTYS-SDQ
30h 40m3 stops
$551Multiple Airlines
Find Deal
Fri, Dec 19 - Sat, Jan 10
Multiple Airlines Logo
3:30 pm - 8:18 amSDQ-TYS
17h 48m2 stops
Multiple Airlines Logo
5:59 pm - 1:39 amTYS-SDQ
30h 40m3 stops
$568Multiple Airlines
Find Deal
Sat, Dec 20 - Sat, Jan 10
Multiple Airlines Logo
3:59 am - 9:34 pmSDQ-TYS
18h 35m3 stops
Multiple Airlines Logo
5:59 pm - 1:39 amTYS-SDQ
30h 40m3 stops
$583Multiple Airlines
Find Deal
Fri, Dec 19 - Sat, Jan 10
Multiple Airlines Logo
3:59 am - 2:55 pmSDQ-TYS
11h 56m2 stops
Multiple Airlines Logo
5:59 pm - 1:39 amTYS-SDQ
30h 40m3 stops
$607Multiple Airlines
Find Deal
Fri, Dec 19 - Sat, Jan 10
American Airlines Logo
5:00 pm - 11:59 pmSDQ-TYS
7h 59m1 stop
American Airlines Logo
6:00 am - 5:48 pmTYS-SDQ
10h 48m1 stop
$636American Airlines
Find Deal
Thu, Feb 19 - Sun, Feb 22
American Airlines Logo
3:19 pm - 11:52 pmSDQ-TYS
9h 33m2 stops
American Airlines Logo
5:49 am - 5:48 pmTYS-SDQ
10h 59m2 stops
$640American Airlines
Find Deal
Thu, Feb 19 - Sun, Feb 22

American Airlines flights from Santo Domingo to Knoxville

Our best American Airlines deals on Santo Domingo to Knoxville flight tickets
American Airlines
Feb 19
SDQ5:00 pmSanto Domingo Las Americas
7h 59m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Feb 22
TYS6:00 amKnoxville McGhee Tyson
10h 48m
1 stop
SDQ5:48 pmSanto Domingo Las Americas
$636
Find similar
American Airlines
Feb 19
SDQ3:19 pmSanto Domingo Las Americas
9h 33m
2 stops
TYS11:52 pmKnoxville McGhee Tyson
Feb 22
TYS5:49 amKnoxville McGhee Tyson
10h 59m
2 stops
SDQ5:48 pmSanto Domingo Las Americas
$640
Find similar
American Airlines
Feb 22
SDQ11:02 amSanto Domingo Las Americas
13h 57m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Feb 28
TYS12:19 pmKnoxville McGhee Tyson
10h 40m
2 stops
SDQ11:59 pmSanto Domingo Las Americas
$725
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 12/20

3:30 pm-10:42 pm

2 stops32h 12m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-5:50 pm

1 stop22h 51m

$422

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 12/19

3:59 am-8:33 pm

1 stop17h 34m

Knoxville McGhee Tyson

Sat 1/10

5:30 pm-1:50 am

2 stops31h 20m

$434

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 12/20

4:23 pm-8:18 am

1 stop16h 55m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-5:50 pm

1 stop22h 51m

$440

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 12/19

3:59 am-8:33 pm

1 stop17h 34m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-5:50 pm

1 stop22h 51m

$443

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 12/19

3:59 am-2:44 pm

1 stop11h 45m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-1:39 am

3 stops30h 40m

$551

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 12/20

3:30 pm-8:18 am

2 stops17h 48m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-1:39 am

3 stops30h 40m

$568

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 12/19

3:59 am-9:34 pm

3 stops18h 35m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-1:39 am

3 stops30h 40m

$583

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 12/19

3:59 am-2:55 pm

2 stops11h 56m

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-1:39 am

3 stops30h 40m

$607

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 2/19

5:00 pm-11:59 pm

1 stop7h 59m

Knoxville McGhee Tyson

Sun 2/22

6:00 am-5:48 pm

1 stop10h 48m

$636

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 2/19

3:19 pm-11:52 pm

2 stops9h 33m

Knoxville McGhee Tyson

Sun 2/22

5:49 am-5:48 pm

2 stops10h 59m

$640

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santo Domingo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santo Domingo to Knoxville is on a Friday. Travelers who choose to depart for Knoxville on a Friday will often find tickets for as low as $541. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Santo Domingo to Knoxville for around $617.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santo Domingo to Knoxville when you can find flight prices for as low as $580. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $592.

Can stopping save me money on Santo Domingo to Knoxville flights?

You could potentially save up to 36% on your flight if you consider stops on a Santo Domingo to Knoxville flight.

When to book flights from Santo Domingo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Knoxville (SDQ to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Knoxville

Direct flights

None
There are no direct flights from Santo Domingo to Knoxville. There are no popular flight routes from Santo Domingo to Knoxville.
Search flight deals

  • How far is Santo Domingo Las Americas to Knoxville McGhee Tyson by plane?

    Santo Domingo Las Americas and Knoxville McGhee Tyson are 1477.4 mi apart from one another. In terms of flight time, this usually takes a little over 7h 59m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to Knoxville?

Best airlines flying from Santo Domingo to Knoxville

Compare and see reviews for airlines that fly from Santo Domingo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $513Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Knoxville?

It is quick and easy to find Santo Domingo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Santo Domingo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Santo Domingo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santo Domingo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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