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Cheap flights from Santo Domingo to Knoxville from $253

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 10/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santo Domingo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:10 am - 1:58 pm
SDQ
-
TYS
8h 48m
1 stop
Multiple Airlines Logo
7:10 am - 4:26 pm
TYS
-
SDQ
8h 16m
1 stop
$506Multiple Airlines
Wed, Nov 4 - Fri, Nov 13
Multiple Airlines Logo
6:10 am - 1:58 pm
SDQ
-
TYS
8h 48m
1 stop
Multiple Airlines Logo
9:10 am - 5:25 am
TYS
-
SDQ
19h 15m
1 stop
$526Multiple Airlines
Wed, Nov 4 - Wed, Nov 11
Multiple Airlines Logo
6:30 am - 11:39 am
SDQ
-
TYS
30h 09m
1 stop
Multiple Airlines Logo
8:30 am - 2:35 am
TYS
-
SDQ
17h 05m
1 stop
$532Multiple Airlines
Fri, Nov 13 - Thu, Dec 3
Multiple Airlines Logo
6:30 am - 11:39 am
SDQ
-
TYS
30h 09m
1 stop
Multiple Airlines Logo
9:10 am - 5:25 am
TYS
-
SDQ
19h 15m
1 stop
$542Multiple Airlines
Fri, Nov 13 - Wed, Dec 2
Multiple Airlines Logo
12:41 pm - 10:04 am
SDQ
-
TYS
21h 23m
2 stops
Multiple Airlines Logo
8:10 am - 5:29 am
TYS
-
SDQ
21h 19m
1 stop
$544Multiple Airlines
Wed, Sep 23 - Wed, Sep 30
Multiple Airlines Logo
7:10 pm - 1:00 pm
SDQ
-
TYS
18h 50m
1 stop
Multiple Airlines Logo
8:30 am - 2:35 am
TYS
-
SDQ
17h 05m
1 stop
$551Multiple Airlines
Wed, Nov 18 - Thu, Dec 3
Multiple Airlines Logo
6:10 am - 2:59 pm
SDQ
-
TYS
9h 49m
1 stop
Multiple Airlines Logo
9:10 am - 5:25 am
TYS
-
SDQ
19h 15m
1 stop
$552Multiple Airlines
Mon, Nov 16 - Wed, Dec 2
Multiple Airlines Logo
7:10 pm - 1:00 pm
SDQ
-
TYS
18h 50m
1 stop
Multiple Airlines Logo
9:10 am - 5:25 am
TYS
-
SDQ
19h 15m
1 stop
$560Multiple Airlines
Wed, Nov 18 - Wed, Dec 2
Multiple Airlines Logo
6:10 am - 2:59 pm
SDQ
-
TYS
9h 49m
1 stop
Multiple Airlines Logo
9:10 am - 5:25 am
TYS
-
SDQ
19h 15m
1 stop
$565Multiple Airlines
Mon, Nov 16 - Fri, Nov 27
Multiple Airlines Logo
7:10 pm - 1:00 pm
SDQ
-
TYS
18h 50m
1 stop
Multiple Airlines Logo
9:10 am - 5:25 am
TYS
-
SDQ
19h 15m
1 stop
$573Multiple Airlines
Wed, Nov 18 - Fri, Nov 27

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Delta flights from Santo Domingo to Knoxville

Our best Delta deals on Santo Domingo to Knoxville flight tickets
Delta
Aug 21
SDQ2:53 pmSanto Domingo Las Americas
8h 59m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Aug 31
TYS6:00 amKnoxville McGhee Tyson
12h 06m
2 stops
SDQ6:06 pmSanto Domingo Las Americas
$582
Delta
Oct 30
SDQ2:56 pmSanto Domingo Las Americas
8h 50m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Nov 17
TYS5:30 amKnoxville McGhee Tyson
8h 10m
1 stop
SDQ2:40 pmSanto Domingo Las Americas
$584
Delta
Oct 30
SDQ7:49 pmSanto Domingo Las Americas
15h 17m
2 stops
TYS11:06 amKnoxville McGhee Tyson
Nov 15
TYS10:05 amKnoxville McGhee Tyson
14h 30m
2 stops
SDQ1:35 amSanto Domingo Las Americas
$592

American Airlines flights from Santo Domingo to Knoxville

Our best American Airlines deals on Santo Domingo to Knoxville flight tickets
American Airlines
Sep 23
SDQ9:30 amSanto Domingo Las Americas
12h 28m
1 stop
TYS9:58 pmKnoxville McGhee Tyson
Sep 30
TYS7:00 amKnoxville McGhee Tyson
11h 34m
1 stop
SDQ6:34 pmSanto Domingo Las Americas
$601
American Airlines
Aug 25
SDQ4:24 pmSanto Domingo Las Americas
18h 21m
2 stops
TYS10:45 amKnoxville McGhee Tyson
Aug 31
TYS7:25 pmKnoxville McGhee Tyson
19h 59m
2 stops
SDQ3:24 pmSanto Domingo Las Americas
$606
American Airlines
Aug 21
SDQ7:00 amSanto Domingo Las Americas
15h 58m
2 stops
TYS10:58 pmKnoxville McGhee Tyson
Aug 31
TYS7:25 pmKnoxville McGhee Tyson
17h 57m
2 stops
SDQ1:22 pmSanto Domingo Las Americas
$618

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 11/4

6:10 am-1:58 pm

1 stop8h 48m

Knoxville McGhee Tyson

Fri 11/13

7:10 am-4:26 pm

1 stop8h 16m

$506

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 11/4

6:10 am-1:58 pm

1 stop8h 48m

Knoxville McGhee Tyson

Wed 11/11

9:10 am-5:25 am

1 stop19h 15m

$526

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 11/13

6:30 am-11:39 am

1 stop30h 09m

Knoxville McGhee Tyson

Thu 12/3

8:30 am-2:35 am

1 stop17h 05m

$532

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 11/13

6:30 am-11:39 am

1 stop30h 09m

Knoxville McGhee Tyson

Wed 12/2

9:10 am-5:25 am

1 stop19h 15m

$542

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 9/23

12:41 pm-10:04 am

2 stops21h 23m

Knoxville McGhee Tyson

Wed 9/30

8:10 am-5:29 am

1 stop21h 19m

$544

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 11/18

7:10 pm-1:00 pm

1 stop18h 50m

Knoxville McGhee Tyson

Thu 12/3

8:30 am-2:35 am

1 stop17h 05m

$551

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 11/16

6:10 am-2:59 pm

1 stop9h 49m

Knoxville McGhee Tyson

Wed 12/2

9:10 am-5:25 am

1 stop19h 15m

$552

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 11/18

7:10 pm-1:00 pm

1 stop18h 50m

Knoxville McGhee Tyson

Wed 12/2

9:10 am-5:25 am

1 stop19h 15m

$560

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 11/16

6:10 am-2:59 pm

1 stop9h 49m

Knoxville McGhee Tyson

Fri 11/27

9:10 am-5:25 am

1 stop19h 15m

$565

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 11/18

7:10 pm-1:00 pm

1 stop18h 50m

Knoxville McGhee Tyson

Fri 11/27

9:10 am-5:25 am

1 stop19h 15m

$573

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santo Domingo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Santo Domingo, with most prices found around $0. If you aren’t able to travel during the month of June, then book flights to Knoxville from Santo Domingo during September instead. Flights to Knoxville in September, while not as cheap as those in June, still average around $515.

Can stopping save me money on Santo Domingo to Knoxville flights?

You could potentially save up to 14% on your flight if you consider stops on a Santo Domingo to Knoxville flight.

When to book flights from Santo Domingo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Knoxville (SDQ to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Knoxville

Fastest flight time

6h 49m

Direct flights

None
The fastest flight from Santo Domingo to Knoxville takes 6h 49m
There are no direct flights from Santo Domingo to Knoxville. There are no popular flight routes from Santo Domingo to Knoxville.
Search flight deals

Frequently asked questions about flying from Santo Domingo to Knoxville

  • How far is Santo Domingo Las Americas to Knoxville McGhee Tyson by plane?

    Santo Domingo Las Americas and Knoxville McGhee Tyson are 1477.4 mi apart from one another. In terms of flight time, this usually takes a little over 6h 49m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to Knoxville?

Best airlines flying from Santo Domingo to Knoxville

Compare and see reviews for airlines that fly from Santo Domingo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $513Free CancellationRating
7.1
11,660 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Knoxville?

It is quick and easy to find Santo Domingo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Santo Domingo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Santo Domingo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santo Domingo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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