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Cheap flights from Santo Domingo to Knoxville from $217

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santo Domingo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:52 am - 8:10 am
SDQ
-
TYS
29h 18m
1 stop
Multiple Airlines Logo
7:40 am - 1:38 am
TYS
-
SDQ
17h 58m
1 stop
$422Multiple Airlines
Thu, Mar 26 - Mon, Mar 30
Multiple Airlines Logo
2:35 pm - 11:06 am
SDQ
-
TYS
20h 31m
1 stop
Multiple Airlines Logo
2:21 pm - 9:40 pm
TYS
-
SDQ
31h 19m
2 stops
$444Multiple Airlines
Fri, May 15 - Mon, Aug 31
Multiple Airlines Logo
2:20 pm - 2:06 pm
SDQ
-
TYS
23h 46m
1 stop
Multiple Airlines Logo
6:20 pm - 9:40 pm
TYS
-
SDQ
27h 20m
2 stops
$446Multiple Airlines
Mon, Apr 6 - Mon, Apr 13
Multiple Airlines Logo
2:20 pm - 2:06 pm
SDQ
-
TYS
23h 46m
1 stop
Multiple Airlines Logo
7:30 am - 1:38 am
TYS
-
SDQ
18h 08m
1 stop
$458Multiple Airlines
Mon, Apr 6 - Mon, Apr 13
Multiple Airlines Logo
2:52 am - 10:36 am
SDQ
-
TYS
7h 44m
1 stop
Multiple Airlines Logo
4:25 pm - 1:29 pm
TYS
-
SDQ
21h 04m
1 stop
$463Multiple Airlines
Tue, Apr 7 - Wed, Apr 15
Multiple Airlines Logo
2:52 am - 8:10 am
SDQ
-
TYS
29h 18m
1 stop
Multiple Airlines Logo
2:06 pm - 1:38 am
TYS
-
SDQ
11h 32m
2 stops
$476Multiple Airlines
Thu, Mar 26 - Mon, Mar 30
Multiple Airlines Logo
2:52 am - 10:36 am
SDQ
-
TYS
7h 44m
1 stop
Multiple Airlines Logo
4:25 pm - 5:29 am
TYS
-
SDQ
37h 04m
2 stops
$508Multiple Airlines
Tue, Apr 7 - Wed, Apr 15
Multiple Airlines Logo
2:35 pm - 11:06 am
SDQ
-
TYS
20h 31m
1 stop
Multiple Airlines Logo
9:10 am - 5:29 am
TYS
-
SDQ
20h 19m
1 stop
$554Multiple Airlines
Fri, May 15 - Mon, Aug 31
American Airlines Logo
4:00 pm - 8:32 am
SDQ
-
TYS
16h 32m
2 stops
American Airlines Logo
8:25 pm - 9:25 am
TYS
-
SDQ
13h 00m
2 stops
$604American Airlines
Fri, May 15 - Mon, Aug 31
American Airlines Logo
10:20 am - 10:24 pm
SDQ
-
TYS
12h 04m
2 stops
American Airlines Logo
5:00 am - 2:59 pm
TYS
-
SDQ
9h 59m
2 stops
$693American Airlines
Wed, Apr 8 - Wed, Apr 15

American Airlines flights from Santo Domingo to Knoxville

Our best American Airlines deals on Santo Domingo to Knoxville flight tickets
American Airlines
May 15
SDQ4:00 pmSanto Domingo Las Americas
16h 32m
2 stops
TYS8:32 amKnoxville McGhee Tyson
Aug 31
TYS8:25 pmKnoxville McGhee Tyson
13h 00m
2 stops
SDQ9:25 amSanto Domingo Las Americas
$604
American Airlines
Apr 8
SDQ10:20 amSanto Domingo Las Americas
12h 04m
2 stops
TYS10:24 pmKnoxville McGhee Tyson
Apr 15
TYS5:00 amKnoxville McGhee Tyson
9h 59m
2 stops
SDQ2:59 pmSanto Domingo Las Americas
$693
American Airlines
Mar 27
SDQ4:03 pmSanto Domingo Las Americas
16h 39m
2 stops
TYS8:42 amKnoxville McGhee Tyson
Mar 30
TYS5:40 amKnoxville McGhee Tyson
11h 10m
2 stops
SDQ4:50 pmSanto Domingo Las Americas
$840

United Airlines flights from Santo Domingo to Knoxville

Our best United Airlines deals on Santo Domingo to Knoxville flight tickets
United Airlines
Apr 9
SDQ1:10 pmSanto Domingo Las Americas
21h 40m
2 stops
TYS10:50 amKnoxville McGhee Tyson
Apr 13
TYS7:20 pmKnoxville McGhee Tyson
18h 50m
2 stops
SDQ2:10 pmSanto Domingo Las Americas
$5,258
United Airlines
Apr 9
SDQ3:20 pmSanto Domingo Las Americas
19h 30m
2 stops
TYS10:50 amKnoxville McGhee Tyson
Apr 13
TYS7:20 pmKnoxville McGhee Tyson
18h 50m
2 stops
SDQ2:10 pmSanto Domingo Las Americas
$5,287

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 3/26

2:52 am-8:10 am

1 stop29h 18m

Knoxville McGhee Tyson

Mon 3/30

7:40 am-1:38 am

1 stop17h 58m

$422

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 5/15

2:35 pm-11:06 am

1 stop20h 31m

Knoxville McGhee Tyson

Mon 8/31

2:21 pm-9:40 pm

2 stops31h 19m

$444

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 4/6

2:20 pm-2:06 pm

1 stop23h 46m

Knoxville McGhee Tyson

Mon 4/13

6:20 pm-9:40 pm

2 stops27h 20m

$446

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 4/6

2:20 pm-2:06 pm

1 stop23h 46m

Knoxville McGhee Tyson

Mon 4/13

7:30 am-1:38 am

1 stop18h 08m

$458

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 4/7

2:52 am-10:36 am

1 stop7h 44m

Knoxville McGhee Tyson

Wed 4/15

4:25 pm-1:29 pm

1 stop21h 04m

$463

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 3/26

2:52 am-8:10 am

1 stop29h 18m

Knoxville McGhee Tyson

Mon 3/30

2:06 pm-1:38 am

2 stops11h 32m

$476

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 4/7

2:52 am-10:36 am

1 stop7h 44m

Knoxville McGhee Tyson

Wed 4/15

4:25 pm-5:29 am

2 stops37h 04m

$508

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 5/15

2:35 pm-11:06 am

1 stop20h 31m

Knoxville McGhee Tyson

Mon 8/31

9:10 am-5:29 am

1 stop20h 19m

$554

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 5/15

4:00 pm-8:32 am

2 stops16h 32m

Knoxville McGhee Tyson

Mon 8/31

8:25 pm-9:25 am

2 stops13h 00m

$604
Quickest round-trip

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 4/8

10:20 am-10:24 pm

2 stops12h 04m

Knoxville McGhee Tyson

Wed 4/15

5:00 am-2:59 pm

2 stops9h 59m

$693

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santo Domingo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santo Domingo, with most prices found around $513. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santo Domingo during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $515.

Can stopping save me money on Santo Domingo to Knoxville flights?

You could potentially save up to 1% on your flight if you consider stops on a Santo Domingo to Knoxville flight.

When to book flights from Santo Domingo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Knoxville (SDQ to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Knoxville

Fastest flight time

7h 38m

Direct flights

None
The fastest flight from Santo Domingo to Knoxville takes 7h 38m
There are no direct flights from Santo Domingo to Knoxville. There are no popular flight routes from Santo Domingo to Knoxville.
Search flight deals

  • How far is Santo Domingo Las Americas to Knoxville McGhee Tyson by plane?

    Santo Domingo Las Americas and Knoxville McGhee Tyson are 1477.4 mi apart from one another. In terms of flight time, this usually takes a little over 7h 38m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to Knoxville?

Best airlines flying from Santo Domingo to Knoxville

Compare and see reviews for airlines that fly from Santo Domingo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $513Free CancellationRating
7.1
11,414 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Knoxville?

It is quick and easy to find Santo Domingo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Santo Domingo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Santo Domingo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santo Domingo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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