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Cheap flights from Santo Domingo to Knoxville from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santo Domingo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:07 pm - 5:33 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
22h 26m2 stops San Juan Luis Munoz Marin Intl Jacksonville
Multiple Airlines Logo
7:30 am - 2:35 amTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
18h 05m1 stop Boston Logan Intl
$535Multiple Airlines
Sat, Oct 24 - Sun, Nov 1
Multiple Airlines Logo
3:35 pm - 10:04 amSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
18h 29m1 stop Miami
Multiple Airlines Logo
6:55 pm - 9:45 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
26h 50m1 stop Fort Lauderdale
$558Multiple Airlines
Sat, Sep 5 - Sat, Sep 12
Delta Logo
2:57 pm - 10:22 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
7h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 2:32 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
7h 52m1 stop Atlanta Hartsfield-Jackson
$616Delta
Sat, Oct 24 - Sun, Nov 1
United Airlines Logo
6:00 am - 3:35 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
9h 35m1 stop Newark
United Airlines Logo
5:20 pm - 3:06 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
20h 46m1 stop Newark
$621United Airlines
Sat, Oct 24 - Sun, Nov 1
Multiple Airlines Logo
10:19 am - 1:04 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
26h 45m1 stop Miami
Multiple Airlines Logo
6:55 pm - 9:45 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
26h 50m1 stop Fort Lauderdale
$622Multiple Airlines
Fri, Aug 28 - Sat, Sep 5
United Airlines Logo
6:00 am - 3:35 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
9h 35m1 stop Newark
United Airlines Logo
5:20 pm - 3:06 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
20h 46m1 stop Newark
$623United Airlines
Sat, Oct 24 - Sun, Nov 1
United Airlines Logo
6:00 am - 3:35 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
9h 35m1 stop Newark
United Airlines Logo
11:25 am - 11:46 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
11h 21m1 stop Newark
$635United Airlines
Sat, Oct 24 - Sun, Nov 1
American Airlines Logo
10:21 am - 11:07 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
12h 46m1 stop Miami
American Airlines Logo
6:00 am - 3:20 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
9h 20m1 stop Miami
$647American Airlines
Sat, Sep 19 - Thu, Oct 8
American Airlines Logo
7:34 pm - 12:27 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
16h 53m2 stops Miami Charlotte Douglas
American Airlines Logo
6:00 am - 8:50 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
14h 50m2 stops Philadelphia Miami
$652American Airlines
Sat, Sep 19 - Thu, Oct 8
American Airlines Logo
2:15 pm - 11:07 pmSDQ  Santo Domingo Las Americas-TYS Knoxville McGhee Tyson
8h 52m1 stop Miami
American Airlines Logo
7:17 am - 8:50 pmTYS  Knoxville McGhee Tyson-SDQ Santo Domingo Las Americas
13h 33m2 stops Washington, D.C. Reagan-National Miami
$652American Airlines
Sat, Sep 19 - Thu, Oct 8

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United Airlines flights from Santo Domingo to Knoxville

Our best United Airlines deals on Santo Domingo to Knoxville flight tickets
United Airlines
Oct 24
SDQ6:00 amSanto Domingo Las Americas
9h 35m
1 stop
TYS3:35 pmKnoxville McGhee Tyson
Nov 1
TYS5:20 pmKnoxville McGhee Tyson
20h 46m
1 stop
SDQ3:06 pmSanto Domingo Las Americas
$621
United Airlines
Oct 24
SDQ6:00 amSanto Domingo Las Americas
9h 35m
1 stop
TYS3:35 pmKnoxville McGhee Tyson
Nov 1
TYS5:20 pmKnoxville McGhee Tyson
20h 46m
1 stop
SDQ3:06 pmSanto Domingo Las Americas
$623
United Airlines
Oct 24
SDQ6:00 amSanto Domingo Las Americas
9h 35m
1 stop
TYS3:35 pmKnoxville McGhee Tyson
Nov 1
TYS11:25 amKnoxville McGhee Tyson
11h 21m
1 stop
SDQ11:46 pmSanto Domingo Las Americas
$635

Delta flights from Santo Domingo to Knoxville

Our best Delta deals on Santo Domingo to Knoxville flight tickets
Delta
Oct 24
SDQ2:57 pmSanto Domingo Las Americas
7h 25m
1 stop
TYS10:22 pmKnoxville McGhee Tyson
Nov 1
TYS5:40 amKnoxville McGhee Tyson
7h 52m
1 stop
SDQ2:32 pmSanto Domingo Las Americas
$616
Delta
Oct 26
SDQ2:57 pmSanto Domingo Las Americas
9h 02m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Oct 31
TYS5:40 amKnoxville McGhee Tyson
12h 26m
2 stops
SDQ6:06 pmSanto Domingo Las Americas
$746

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 10/24

7:07 pm-5:33 pm

2 stops22h 26m

Knoxville McGhee Tyson

Sun 11/1

7:30 am-2:35 am

1 stop18h 05m

$535

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 9/5

3:35 pm-10:04 am

1 stop18h 29m

Knoxville McGhee Tyson

Sat 9/12

6:55 pm-9:45 pm

1 stop26h 50m

$558
Quickest round-trip

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 10/24

2:57 pm-10:22 pm

1 stop7h 25m

Knoxville McGhee Tyson

Sun 11/1

5:40 am-2:32 pm

1 stop7h 52m

$616

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 10/24

6:00 am-3:35 pm

1 stop9h 35m

Knoxville McGhee Tyson

Sun 11/1

5:20 pm-3:06 pm

1 stop20h 46m

$621

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Fri 8/28

10:19 am-1:04 pm

1 stop26h 45m

Knoxville McGhee Tyson

Sat 9/5

6:55 pm-9:45 pm

1 stop26h 50m

$622

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 10/24

6:00 am-3:35 pm

1 stop9h 35m

Knoxville McGhee Tyson

Sun 11/1

5:20 pm-3:06 pm

1 stop20h 46m

$623

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 10/24

6:00 am-3:35 pm

1 stop9h 35m

Knoxville McGhee Tyson

Sun 11/1

11:25 am-11:46 pm

1 stop11h 21m

$635

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 9/19

10:21 am-11:07 pm

1 stop12h 46m

Knoxville McGhee Tyson

Thu 10/8

6:00 am-3:20 pm

1 stop9h 20m

$647

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 9/19

7:34 pm-12:27 pm

2 stops16h 53m

Knoxville McGhee Tyson

Thu 10/8

6:00 am-8:50 pm

2 stops14h 50m

$652

Santo DomingoKnoxville

SDQ Santo Domingo Las Americas - TYS Knoxville McGhee Tyson

SDQTYS

Santo Domingo Las Americas

Sat 9/19

2:15 pm-11:07 pm

1 stop8h 52m

Knoxville McGhee Tyson

Thu 10/8

7:17 am-8:50 pm

2 stops13h 33m

$652

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santo Domingo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $572 to $765.
The lowest price recently found on this route was $529.

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Santo Domingo, with most prices found around $0. If you aren’t able to travel during the month of June, then book flights to Knoxville from Santo Domingo during November instead. Flights to Knoxville in November, while not as cheap as those in June, still average around $528.

Can stopping save me money on Santo Domingo to Knoxville flights?

You could potentially save up to 9% on your flight if you consider stops on a Santo Domingo to Knoxville flight.

When to book flights from Santo Domingo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Knoxville (SDQ to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Knoxville

Fastest flight time

9h 02m

Direct flights

None
The fastest flight from Santo Domingo to Knoxville takes 9h 02m
There are no direct flights from Santo Domingo to Knoxville. There are no popular flight routes from Santo Domingo to Knoxville.
Search flight deals

Frequently asked questions about flying from Santo Domingo to Knoxville

  • How far is Santo Domingo Las Americas to Knoxville McGhee Tyson by plane?

    Santo Domingo Las Americas and Knoxville McGhee Tyson are 1477.4 mi apart from one another. In terms of flight time, this usually takes a little over 9h 02m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to Knoxville?

Best airlines flying from Santo Domingo to Knoxville

Compare and see reviews for airlines that fly from Santo Domingo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $567Free CancellationRating
7.1
11,903 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Knoxville?

It is quick and easy to find Santo Domingo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Santo Domingo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Santo Domingo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santo Domingo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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