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Cheap flights from Santo Domingo to Knoxville from $520

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Knoxville departing on 1/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santo Domingo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:28 pm - 11:14 pm
SDQ
-
TYS
9h 46m1 stop
American Airlines Logo
7:15 am - 9:50 pm
TYS
-
SDQ
14h 35m1 stop
$2,819American Airlines
Sat, May 9 - Sun, May 10
American Airlines Logo
5:55 am - 3:50 pm
SDQ
-
TYS
9h 55m2 stops
American Airlines Logo
7:15 am - 2:15 pm
TYS
-
SDQ
7h 00m1 stop
$2,824American Airlines
Sat, May 9 - Sun, May 10
American Airlines Logo
5:55 am - 3:50 pm
SDQ
-
TYS
9h 55m2 stops
American Airlines Logo
12:50 pm - 7:45 pm
TYS
-
SDQ
6h 55m2 stops
$2,858American Airlines
Sat, May 9 - Sun, May 10
United Airlines Logo
2:53 pm - 10:56 am
SDQ
-
TYS
21h 03m2 stops
United Airlines Logo
7:23 pm - 3:06 pm
TYS
-
SDQ
18h 43m2 stops
$5,187United Airlines
Mon, Dec 29 - Wed, Dec 31

American Airlines flights from Santo Domingo to Knoxville

Our best American Airlines deals on Santo Domingo to Knoxville flight tickets
American Airlines
Dec 24
SDQ4:51 pmSanto Domingo Las Americas
8h 47m
1 stop
TYS12:38 amKnoxville McGhee Tyson
Jan 5
TYS5:42 amKnoxville McGhee Tyson
15h 18m
1 stop
SDQ10:00 pmSanto Domingo Las Americas
$571
Find similar
American Airlines
Dec 24
SDQ3:16 pmSanto Domingo Las Americas
22h 36m
2 stops
TYS12:52 pmKnoxville McGhee Tyson
Jan 5
TYS10:49 amKnoxville McGhee Tyson
10h 11m
1 stop
SDQ10:00 pmSanto Domingo Las Americas
$575
Find similar
American Airlines
Dec 24
SDQ10:07 amSanto Domingo Las Americas
10h 34m
2 stops
TYS7:41 pmKnoxville McGhee Tyson
Jan 5
TYS8:30 amKnoxville McGhee Tyson
8h 21m
2 stops
SDQ5:51 pmSanto Domingo Las Americas
$1,241
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 5/9

1:28 pm-11:14 pm

1 stop9h 46m

Knoxville McGhee Tyson

Sun 5/10

7:15 am-9:50 pm

1 stop14h 35m

$2,819

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 5/9

5:55 am-3:50 pm

2 stops9h 55m

Knoxville McGhee Tyson

Sun 5/10

7:15 am-2:15 pm

1 stop7h 00m

$2,824

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 5/9

5:55 am-3:50 pm

2 stops9h 55m

Knoxville McGhee Tyson

Sun 5/10

12:50 pm-7:45 pm

2 stops6h 55m

$2,858

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 12/29

2:53 pm-10:56 am

2 stops21h 03m

Knoxville McGhee Tyson

Wed 12/31

7:23 pm-3:06 pm

2 stops18h 43m

$5,187

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 1/3

8:20 am-8:18 am

2 stops24h 58m

$520

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 1/2

3:59 am-8:18 am

1 stop29h 19m

$597

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santo Domingo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santo Domingo to Knoxville when you can find flight prices for as low as $580. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $592.

Can stopping save me money on Santo Domingo to Knoxville flights?

You could potentially save up to 36% on your flight if you consider stops on a Santo Domingo to Knoxville flight.

When to book flights from Santo Domingo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Knoxville (SDQ to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Knoxville

Fastest flight time

8h 53m

Direct flights

None
The fastest flight from Santo Domingo to Knoxville takes 8h 53m
There are no direct flights from Santo Domingo to Knoxville. There are no popular flight routes from Santo Domingo to Knoxville.
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  • How far is Santo Domingo Las Americas to Knoxville McGhee Tyson by plane?

    Santo Domingo Las Americas and Knoxville McGhee Tyson are 1477.4 mi apart from one another. In terms of flight time, this usually takes a little over 8h 53m.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santo Domingo Las Americas Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santo Domingo to Knoxville?

Best airlines flying from Santo Domingo to Knoxville

Compare and see reviews for airlines that fly from Santo Domingo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $513Free CancellationRating
7.2
11,055 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Knoxville?

It is quick and easy to find Santo Domingo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Santo Domingo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Santo Domingo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santo Domingo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santo Domingo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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