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Cheap flights from San Antonio to South America from $116

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to South America departing on 4/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Antonio to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
10:27 am - 12:21 am
SAT
-
MDE
13h 54m
1 stop
Spirit Airlines Logo
1:17 am - 9:32 am
MDE
-
SAT
8h 15m
1 stop
$269Spirit Airlines
Fri, Mar 13 - Mon, Mar 30
Spirit Airlines Logo
10:27 am - 12:21 am
SAT
-
MDE
13h 54m
1 stop
Spirit Airlines Logo
1:17 am - 9:32 am
MDE
-
SAT
8h 15m
1 stop
$270Spirit Airlines
Fri, Mar 13 - Thu, Mar 19
Spirit Airlines Logo
10:27 am - 12:21 am
SAT
-
MDE
13h 54m
1 stop
Spirit Airlines Logo
1:17 am - 9:32 am
MDE
-
SAT
8h 15m
1 stop
$275Spirit Airlines
Wed, Mar 18 - Sun, Mar 22
Spirit Airlines Logo
10:27 am - 12:21 am
SAT
-
MDE
13h 54m
1 stop
Spirit Airlines Logo
1:17 am - 9:32 am
MDE
-
SAT
8h 15m
1 stop
$283Spirit Airlines
Sat, Mar 14 - Mon, Mar 30
United Airlines Logo
9:58 am - 3:44 am
SAT
-
VVI
15h 46m
2 stops
United Airlines Logo
11:44 am - 8:43 am
VVI
-
SAT
22h 59m
2 stops
$670United Airlines
Mon, Feb 23 - Thu, Feb 26
LATAM Airlines Logo
8:00 am - 5:35 am
SAT
-
SCL
18h 35m
2 stops
LATAM Airlines Logo
5:15 am - 12:38 am
SCL
-
SAT
21h 23m
2 stops
$807LATAM Airlines
Wed, Mar 4 - Wed, Mar 18
LATAM Airlines Logo
4:29 pm - 7:40 am
SAT
-
SCL
13h 11m
1 stop
LATAM Airlines Logo
8:40 pm - 9:55 am
SCL
-
SAT
15h 15m
1 stop
$820LATAM Airlines
Mon, Mar 23 - Wed, Apr 1
United Airlines Logo
6:52 pm - 8:50 am
SAT
-
SCL
10h 58m
1 stop
United Airlines Logo
9:45 pm - 10:47 am
SCL
-
SAT
15h 02m
1 stop
$860United Airlines
Thu, Mar 5 - Sat, Mar 14
Delta Logo
12:15 pm - 10:15 am
SAT
-
GIG
20h 00m
1 stop
Delta Logo
5:20 pm - 11:19 am
GIG
-
SAT
19h 59m
2 stops
$1,027Delta
Sun, May 31 - Mon, Jun 8
American Airlines Logo
5:09 pm - 8:50 am
SAT
-
EZE
13h 41m
1 stop
American Airlines Logo
11:30 pm - 4:39 pm
EZE
-
SAT
19h 09m
1 stop
$1,037American Airlines
Mon, Apr 13 - Thu, Apr 30

Spirit Airlines flights from San Antonio to South America

Our best Spirit Airlines deals on San Antonio to South America flight tickets
Spirit Airlines
Mar 13
SAT10:27 amSan Antonio
13h 54m
1 stop
MDE12:21 amMedellín Jose Maria Cordova Intl
Mar 30
MDE1:17 amMedellín Jose Maria Cordova Intl
8h 15m
1 stop
SAT9:32 amSan Antonio
$269
Spirit Airlines
Mar 13
SAT10:27 amSan Antonio
13h 54m
1 stop
MDE12:21 amMedellín Jose Maria Cordova Intl
Mar 19
MDE1:17 amMedellín Jose Maria Cordova Intl
8h 15m
1 stop
SAT9:32 amSan Antonio
$270
Spirit Airlines
Mar 18
SAT10:27 amSan Antonio
13h 54m
1 stop
MDE12:21 amMedellín Jose Maria Cordova Intl
Mar 22
MDE1:17 amMedellín Jose Maria Cordova Intl
8h 15m
1 stop
SAT9:32 amSan Antonio
$275

American Airlines flights from San Antonio to South America

Our best American Airlines deals on San Antonio to South America flight tickets
American Airlines
May 14
SAT9:36 amSan Antonio
12h 54m
1 stop
BOG10:30 pmBogotá El Dorado
May 23
BOG12:25 pmBogotá El Dorado
11h 34m
1 stop
SAT11:59 pmSan Antonio
$437
American Airlines
Feb 4
SAT5:10 amSan Antonio
7h 20m
1 stop
CTG1:30 pmCartagena Rafael Nunez
Feb 10
CTG4:30 pmCartagena Rafael Nunez
8h 29m
1 stop
SAT11:59 pmSan Antonio
$461
American Airlines
Feb 4
SAT5:00 pmSan Antonio
19h 30m
2 stops
CTG1:30 pmCartagena Rafael Nunez
Feb 10
CTG4:30 pmCartagena Rafael Nunez
8h 29m
1 stop
SAT11:59 pmSan Antonio
$466

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from San Antonio to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioMedellín

SAT - MDE

SATMDE

San Antonio

Fri 3/13

10:27 am-12:21 am

1 stop13h 54m

Medellín Jose Maria Cordova Intl

Mon 3/30

1:17 am-9:32 am

1 stop8h 15m

$269

San AntonioMedellín

SAT - MDE

SATMDE

San Antonio

Fri 3/13

10:27 am-12:21 am

1 stop13h 54m

Medellín Jose Maria Cordova Intl

Thu 3/19

1:17 am-9:32 am

1 stop8h 15m

$270

San AntonioMedellín

SAT - MDE

SATMDE

San Antonio

Wed 3/18

10:27 am-12:21 am

1 stop13h 54m

Medellín Jose Maria Cordova Intl

Sun 3/22

1:17 am-9:32 am

1 stop8h 15m

$275

San AntonioMedellín

SAT - MDE

SATMDE

San Antonio

Sat 3/14

10:27 am-12:21 am

1 stop13h 54m

Medellín Jose Maria Cordova Intl

Mon 3/30

1:17 am-9:32 am

1 stop8h 15m

$283

San AntonioSanta Cruz de la Sierra

SAT - VVI

SATVVI

San Antonio

Mon 2/23

9:58 am-3:44 am

2 stops15h 46m

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/26

11:44 am-8:43 am

2 stops22h 59m

$670

San AntonioSantiago

SAT - SCL

SATSCL

San Antonio

Wed 3/4

8:00 am-5:35 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Wed 3/18

5:15 am-12:38 am

2 stops21h 23m

$807

San AntonioSantiago

SAT - SCL

SATSCL

San Antonio

Mon 3/23

4:29 pm-7:40 am

1 stop13h 11m

Santiago Arturo Merino Benitez

Wed 4/1

8:40 pm-9:55 am

1 stop15h 15m

$820

San AntonioSantiago

SAT - SCL

SATSCL

San Antonio

Thu 3/5

6:52 pm-8:50 am

1 stop10h 58m

Santiago Arturo Merino Benitez

Sat 3/14

9:45 pm-10:47 am

1 stop15h 02m

$860

San AntonioRio de Janeiro

SAT - GIG

SATGIG

San Antonio

Sun 5/31

12:15 pm-10:15 am

1 stop20h 00m

Rio de Janeiro–Galeão Intl

Mon 6/8

5:20 pm-11:19 am

2 stops19h 59m

$1,027

San AntonioBuenos Aires

SAT - EZE

SATEZE

San Antonio

Mon 4/13

5:09 pm-8:50 am

1 stop13h 41m

Buenos Aires Ministro Pistarini

Thu 4/30

11:30 pm-4:39 pm

1 stop19h 09m

$1,037

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Antonio to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from San Antonio to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $615. If you aren’t able to travel during the month of February, then book flights to South America from San Antonio during March instead. Flights to South America in March, while not as cheap as those in February, still average around $648.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $723 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Antonio for as low as $615 on momondo.

Can stopping save me money on San Antonio to South America flights?

You could potentially save up to 25% on your flight if you consider stops on a San Antonio to South America flight.

Cheap San Antonio to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to South America

Fastest flight time

8h 24m

Direct flights

None
The fastest flight from San Antonio to South America takes 8h 24m
There are no direct flights from San Antonio to South America. There are no popular flight routes from San Antonio to South America.
Search flight deals

  • When did momondo last update prices for flights from San Antonio Airport to South America?

    Prices for flights from San Antonio Airport to South America are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Antonio Airport to South America?

  • How old do you have to be to fly from San Antonio Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Antonio Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from San Antonio to South America

Compare and see reviews for airlines that fly from San Antonio to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $285Free CancellationRating
6.3
8,394 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $414Free CancellationRating
7.2
11,206 reviews
Search American Airlines flights
United AirlinesPriceFrom $414Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights
DeltaPriceFrom $414Free CancellationRating
7.9
8,127 reviews
Search Delta flights
LATAM AirlinesPriceFrom $419Free CancellationRating
7.5
1,918 reviews
Search LATAM Airlines flights
AeromexicoPriceFrom $648Free CancellationRating
7.4
1,586 reviews
Search Aeromexico flights

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from San Antonio.

Can I find flights from San Antonio to South America with flexible booking policies on momondo?

All flight searches from San Antonio to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Antonio to South America?

Once you have performed a search for San Antonio to South America flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Antonio to South America right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to South America flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
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