What airlines fly to South America?

Delta, LATAM Airlines and American Airlines are the top three most popular airlines that fly to South America from Roanoke according to our data. Delta is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Roanoke to South America?

Delta, United Airlines, and GOL are the most popular carriers operating from Roanoke to South America

When did momondo last update prices for flights from Roanoke Airport to South America?

Prices for flights from Roanoke Airport to South America refresh daily.

How many operators does momondo search for flights from Roanoke Airport to South America?

As of February 2026, there is 1 operator available to choose from for flights from Roanoke Airport to South America.

How old do you have to be to fly from Roanoke Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$566 Cheap Flights from Roanoke to South America in 2026

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Find the cheapest flights from Roanoke to South America

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:00 pm - 1:30 pm

ROA

GYE

18h 30m

2 stops

2:31 pm - 12:33 pm

GYE

ROA

21h 02m

2 stops

$566American Airlines

Sun, Apr 5 - Sun, Apr 12

5:00 am - 8:58 pm

ROA

UIO

16h 58m

2 stops

11:40 pm - 2:25 pm

UIO

ROA

13h 45m

2 stops

$642American Airlines

Tue, Aug 11 - Thu, Aug 27

5:00 am - 8:58 pm

ROA

UIO

16h 58m

2 stops

11:40 pm - 2:25 pm

UIO

ROA

13h 45m

2 stops

$662American Airlines

Tue, Aug 11 - Thu, Aug 27

6:00 am - 11:25 pm

ROA

UIO

18h 25m

2 stops

12:35 am - 11:44 pm

UIO

ROA

22h 09m

2 stops

$726United Airlines

Tue, May 5 - Thu, May 7

6:00 am - 11:25 pm

ROA

UIO

18h 25m

2 stops

12:35 am - 11:44 pm

UIO

ROA

22h 09m

2 stops

$746United Airlines

Tue, May 5 - Thu, May 7

11:20 am - 4:43 am

ROA

UIO

18h 23m

2 stops

12:59 am - 11:50 pm

UIO

ROA

21h 51m

1 stop

$753Delta

Tue, Aug 11 - Wed, Aug 26

6:00 am - 4:43 am

ROA

UIO

23h 43m

2 stops

12:59 am - 10:30 am

UIO

ROA

8h 31m

1 stop

$778LATAM Airlines

Tue, May 5 - Thu, May 7

11:20 am - 6:59 pm

ROA

UIO

8h 39m

1 stop

12:59 am - 10:35 am

UIO

ROA

8h 36m

1 stop

$816LATAM Airlines

Tue, Aug 11 - Wed, Aug 26

6:00 am - 6:59 pm

ROA

UIO

13h 59m

1 stop

12:59 am - 11:50 pm

UIO

ROA

21h 51m

1 stop

$878Delta

Tue, Aug 11 - Wed, Aug 26

2:55 pm - 4:45 pm

ROA

SDU

24h 50m

3 stops

1:45 pm - 2:13 pm

SDU

ROA

25h 28m

3 stops

$1,919Air Canada

Mon, Apr 6 - Mon, Apr 13

LATAM Airlines flights from Roanoke to South America

Our best LATAM Airlines deals on Roanoke to South America flight tickets

LATAM Airlines

May 5

ROA6:00 amRoanoke

23h 43m

2 stops

UIO4:43 amQuito Mariscal Sucr

May 7

UIO12:59 amQuito Mariscal Sucr

8h 31m

1 stop

ROA10:30 amRoanoke

$778

LATAM Airlines

Aug 11

ROA11:20 amRoanoke

8h 39m

1 stop

UIO6:59 pmQuito Mariscal Sucr

Aug 26

UIO12:59 amQuito Mariscal Sucr

8h 36m

1 stop

ROA10:35 amRoanoke

$816

LATAM Airlines

May 29

ROA6:00 amRoanoke

24h 00m

2 stops

SCL6:00 amSantiago Arturo Merino Benitez

Jun 13

SCL11:05 pmSantiago Arturo Merino Benitez

24h 44m

2 stops

ROA11:49 pmRoanoke

$913

American Airlines flights from Roanoke to South America

Our best American Airlines deals on Roanoke to South America flight tickets

American Airlines

Apr 5

ROA8:00 pmRoanoke

18h 30m

2 stops

GYE1:30 pmGuayaquil Jose Joaquin de Olmedo

Apr 12

GYE2:31 pmGuayaquil Jose Joaquin de Olmedo

21h 02m

2 stops

ROA12:33 pmRoanoke

$566

American Airlines

Aug 11

ROA5:00 amRoanoke

16h 58m

2 stops

UIO8:58 pmQuito Mariscal Sucr

Aug 27

UIO11:40 pmQuito Mariscal Sucr

13h 45m

2 stops

ROA2:25 pmRoanoke

$642

American Airlines

Aug 11

ROA5:00 amRoanoke

16h 58m

2 stops

UIO8:58 pmQuito Mariscal Sucr

Aug 27

UIO11:40 pmQuito Mariscal Sucr

13h 45m

2 stops

ROA2:25 pmRoanoke

$662

Fly from

Fly to

Route

Depart

Return

Price

RoanokeGuayaquil

ROA - GYE

ROAGYE

Roanoke

Sun 4/5

8:00 pm-1:30 pm

2 stops18h 30m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

2:31 pm-12:33 pm

2 stops21h 02m

$566

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 8/11

5:00 am-8:58 pm

2 stops16h 58m

Quito Mariscal Sucr

Thu 8/27

11:40 pm-2:25 pm

2 stops13h 45m

$642

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 8/11

5:00 am-8:58 pm

2 stops16h 58m

Quito Mariscal Sucr

Thu 8/27

11:40 pm-2:25 pm

2 stops13h 45m

$662

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 5/5

6:00 am-11:25 pm

2 stops18h 25m

Quito Mariscal Sucr

Thu 5/7

12:35 am-11:44 pm

2 stops22h 09m

$726

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 5/5

6:00 am-11:25 pm

2 stops18h 25m

Quito Mariscal Sucr

Thu 5/7

12:35 am-11:44 pm

2 stops22h 09m

$746

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 8/11

11:20 am-4:43 am

2 stops18h 23m

Quito Mariscal Sucr

Wed 8/26

12:59 am-11:50 pm

1 stop21h 51m

$753

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 5/5

6:00 am-4:43 am

2 stops23h 43m

Quito Mariscal Sucr

Thu 5/7

12:59 am-10:30 am

1 stop8h 31m

$778

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 8/11

11:20 am-6:59 pm

1 stop8h 39m

Quito Mariscal Sucr

Wed 8/26

12:59 am-10:35 am

1 stop8h 36m

$816

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 8/11

6:00 am-6:59 pm

1 stop13h 59m

Quito Mariscal Sucr

Wed 8/26

12:59 am-11:50 pm

1 stop21h 51m

$878

RoanokeRio de Janeiro

ROA - SDU

ROASDU

Roanoke

Mon 4/6

2:55 pm-4:45 pm

3 stops24h 50m

Rio de Janeiro Santos Dumont

Mon 4/13

1:45 pm-2:13 pm

3 stops25h 28m

$1,919

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first

How to get the cheapest flight ticket from Roanoke to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Can stopping save me money on Roanoke to South America flights?

You could potentially save up to 4% on your flight if you consider stops on a Roanoke to South America flight.

Cheap Roanoke to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to South America

Fastest flight time	11h 36m
Direct flights	None

The fastest flight from Roanoke to South America takes 11h 36m

There are no direct flights from Roanoke to South America. There are no popular flight routes from Roanoke to South America.

Search flight deals

When did momondo last update prices for flights from Roanoke Airport to South America?
Prices for flights from Roanoke Airport to South America refresh daily.
How many operators does momondo search for flights from Roanoke Airport to South America?
As of February 2026, there is 1 operator available to choose from for flights from Roanoke Airport to South America.
How old do you have to be to fly from Roanoke Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Roanoke to South America

Compare and see reviews for airlines that fly from Roanoke to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $746	Free Cancellation	Rating 7.9 8,215 reviews		Search Delta flights
LATAM Airlines	PriceFrom $857	Free Cancellation	Rating 7.5 1,919 reviews		Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Roanoke with this policy.

How can momondo help me find flights from Roanoke to South America?

Once all potential Roanoke to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Roanoke to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Roanoke to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.