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Cheap flights from Roanoke to Des Moines from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Des Moines departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Roanoke to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:35 pm - 12:20 amROA  Roanoke-DSM Des Moines
7h 45m1 stop Chicago O'Hare Intl
American Airlines Logo
5:10 pm - 10:49 pmDSM  Des Moines-ROA Roanoke
4h 39m1 stop Charlotte Douglas
$319American Airlines
Tue, Sep 1 - Mon, Sep 7
American Airlines Logo
8:11 am - 12:24 pmROA  Roanoke-DSM Des Moines
5h 13m1 stop Charlotte Douglas
American Airlines Logo
1:08 pm - 9:10 pmDSM  Des Moines-ROA Roanoke
7h 02m1 stop Charlotte Douglas
$319American Airlines
Tue, Sep 1 - Mon, Sep 7
Delta Logo
6:38 pm - 10:33 pmROA  Roanoke-DSM Des Moines
4h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:54 pm - 12:27 amDSM  Des Moines-ROA Roanoke
4h 33m1 stop Atlanta Hartsfield-Jackson
$319Delta
Fri, Oct 16 - Fri, Oct 23
American Airlines Logo
10:35 am - 7:19 pmROA  Roanoke-DSM Des Moines
9h 44m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
5:10 pm - 10:49 pmDSM  Des Moines-ROA Roanoke
4h 39m1 stop Charlotte Douglas
$324American Airlines
Tue, Sep 1 - Mon, Sep 7
United Airlines Logo
10:30 am - 2:26 pmROA  Roanoke-DSM Des Moines
4h 56m1 stop Chicago O'Hare Intl
United Airlines Logo
6:05 am - 2:15 pmDSM  Des Moines-ROA Roanoke
7h 10m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$367United Airlines
Sat, Oct 31 - Thu, Nov 5
United Airlines Logo
5:51 pm - 9:45 pmROA  Roanoke-DSM Des Moines
4h 54m1 stop Chicago O'Hare Intl
United Airlines Logo
6:05 am - 1:26 pmDSM  Des Moines-ROA Roanoke
6h 21m1 stop Chicago O'Hare Intl
$386United Airlines
Sat, Oct 31 - Thu, Nov 5
United Airlines Logo
5:51 pm - 10:50 pmROA  Roanoke-DSM Des Moines
5h 59m1 stop Chicago O'Hare Intl
United Airlines Logo
1:05 pm - 9:01 pmDSM  Des Moines-ROA Roanoke
6h 56m1 stop Chicago O'Hare Intl
$399United Airlines
Wed, Nov 11 - Sat, Nov 14
Delta Logo
6:54 pm - 10:34 pmROA  Roanoke-DSM Des Moines
4h 40m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 pm - 12:23 amDSM  Des Moines-ROA Roanoke
6h 08m1 stop Atlanta Hartsfield-Jackson
$509Delta
Fri, Dec 18 - Tue, Jan 5
Delta Logo
6:54 pm - 10:34 pmROA  Roanoke-DSM Des Moines
4h 40m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 pm - 12:23 amDSM  Des Moines-ROA Roanoke
6h 08m1 stop Atlanta Hartsfield-Jackson
$509Delta
Fri, Dec 18 - Mon, Jan 4
American Airlines Logo
6:15 am - 12:23 pmROA  Roanoke-DSM Des Moines
7h 08m1 stop Charlotte Douglas
American Airlines Logo
7:05 am - 2:41 pmDSM  Des Moines-ROA Roanoke
6h 36m1 stop Charlotte Douglas
$547American Airlines
Tue, Oct 20 - Wed, Oct 21

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Delta flights from Roanoke to Des Moines

Our best Delta deals on Roanoke to Des Moines flight tickets
Delta
Oct 16
ROA6:38 pmRoanoke
4h 55m
1 stop
DSM10:33 pmDes Moines
Oct 23
DSM6:54 pmDes Moines
4h 33m
1 stop
ROA12:27 amRoanoke
$319
Delta
Dec 18
ROA6:54 pmRoanoke
4h 40m
1 stop
DSM10:34 pmDes Moines
Jan 4
DSM5:15 pmDes Moines
6h 08m
1 stop
ROA12:23 amRoanoke
$509
Delta
Oct 16
ROA11:12 amRoanoke
8h 59m
2 stops
DSM7:11 pmDes Moines
Oct 23
DSM6:54 pmDes Moines
4h 33m
1 stop
ROA12:27 amRoanoke
$584

United Airlines flights from Roanoke to Des Moines

Our best United Airlines deals on Roanoke to Des Moines flight tickets
United Airlines
Aug 13
ROA6:40 amRoanoke
4h 46m
1 stop
DSM10:26 amDes Moines
Aug 27
DSM11:32 amDes Moines
4h 37m
1 stop
ROA5:09 pmRoanoke
$364
United Airlines
Oct 31
ROA10:30 amRoanoke
4h 56m
1 stop
DSM2:26 pmDes Moines
Nov 5
DSM6:05 amDes Moines
7h 10m
2 stops
ROA2:15 pmRoanoke
$367
United Airlines
Aug 13
ROA6:40 amRoanoke
4h 46m
1 stop
DSM10:26 amDes Moines
Sep 2
DSM8:00 amDes Moines
10h 07m
2 stops
ROA7:07 pmRoanoke
$369

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 8, 2026.
Use the filters below to find and compare flights from Roanoke to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Tue 9/1

5:35 pm-12:20 am

1 stop7h 45m

Des Moines

Mon 9/7

5:10 pm-10:49 pm

1 stop4h 39m

$319

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Tue 9/1

8:11 am-12:24 pm

1 stop5h 13m

Des Moines

Mon 9/7

1:08 pm-9:10 pm

1 stop7h 02m

$319
Quickest round-trip

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Fri 10/16

6:38 pm-10:33 pm

1 stop4h 55m

Des Moines

Fri 10/23

6:54 pm-12:27 am

1 stop4h 33m

$319

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Tue 9/1

10:35 am-7:19 pm

2 stops9h 44m

Des Moines

Mon 9/7

5:10 pm-10:49 pm

1 stop4h 39m

$324

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Sat 10/31

10:30 am-2:26 pm

1 stop4h 56m

Des Moines

Thu 11/5

6:05 am-2:15 pm

2 stops7h 10m

$367

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Sat 10/31

5:51 pm-9:45 pm

1 stop4h 54m

Des Moines

Thu 11/5

6:05 am-1:26 pm

1 stop6h 21m

$386

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Wed 11/11

5:51 pm-10:50 pm

1 stop5h 59m

Des Moines

Sat 11/14

1:05 pm-9:01 pm

1 stop6h 56m

$399

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Fri 12/18

6:54 pm-10:34 pm

1 stop4h 40m

Des Moines

Tue 1/5

5:15 pm-12:23 am

1 stop6h 08m

$509

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Fri 12/18

6:54 pm-10:34 pm

1 stop4h 40m

Des Moines

Mon 1/4

5:15 pm-12:23 am

1 stop6h 08m

$509

RoanokeDes Moines

ROA Roanoke - DSM Des Moines

ROADSM

Roanoke

Tue 10/20

6:15 am-12:23 pm

1 stop7h 08m

Des Moines

Wed 10/21

7:05 am-2:41 pm

1 stop6h 36m

$547

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Roanoke to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then October is your next best option. Flight prices from Roanoke to Des Moines during October average around $318.

When to book flights from Roanoke to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Des Moines (ROA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Des Moines

Fastest flight time

4h 33m

Direct flights

None
The fastest flight from Roanoke to Des Moines takes 4h 33m
There are no direct flights from Roanoke to Des Moines. There are no popular flight routes from Roanoke to Des Moines.
Search flight deals

Frequently asked questions about flying from Roanoke to Des Moines

  • How far is Roanoke to Des Moines by plane?

    The distance between Roanoke and Des Moines is about 787.3 mi. Typically, this will take 4h 33m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?

    Prices for flights from Roanoke Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?

  • How old do you have to be to fly from Roanoke Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Roanoke to Des Moines?

Best airlines flying from Roanoke to Des Moines

Compare and see reviews for airlines that fly from Roanoke to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
10,085 reviews
Search United Airlines flights
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,885 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Roanoke.

I’m not ready to book a flight from Roanoke to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Roanoke and alert you when they change.

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