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Cheap flights from Roanoke to Des Moines from $245

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Des Moines departing on 3/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Roanoke to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:28 am - 11:30 am
ROA
-
DSM
5h 02m
1 stop
American Airlines Logo
5:01 pm - 12:10 am
DSM
-
ROA
6h 09m
1 stop
$269American Airlines
Fri, Apr 24 - Mon, Apr 27
American Airlines Logo
7:28 am - 1:46 pm
ROA
-
DSM
7h 18m
1 stop
American Airlines Logo
3:00 pm - 10:26 pm
DSM
-
ROA
6h 26m
1 stop
$289American Airlines
Fri, Apr 24 - Mon, Apr 27
Delta Logo
6:00 am - 10:14 am
ROA
-
DSM
5h 14m
1 stop
Delta Logo
6:30 pm - 11:49 pm
DSM
-
ROA
4h 19m
1 stop
$304Delta
Tue, Jul 28 - Wed, Aug 5
American Airlines Logo
7:05 am - 1:07 pm
ROA
-
DSM
7h 02m
1 stop
American Airlines Logo
6:40 am - 11:59 pm
DSM
-
ROA
16h 19m
1 stop
$312American Airlines
Thu, Apr 2 - Sun, Apr 5
United Airlines Logo
5:40 pm - 10:59 pm
ROA
-
DSM
6h 19m
1 stop
United Airlines Logo
1:05 pm - 8:54 pm
DSM
-
ROA
6h 49m
1 stop
$339United Airlines
Tue, Apr 28 - Sat, May 2
United Airlines Logo
5:40 pm - 10:59 pm
ROA
-
DSM
6h 19m
1 stop
United Airlines Logo
6:15 am - 7:10 pm
DSM
-
ROA
11h 55m
2 stops
$344United Airlines
Tue, Apr 28 - Sat, May 2
United Airlines Logo
8:37 am - 4:10 pm
ROA
-
DSM
8h 33m
2 stops
United Airlines Logo
8:00 am - 7:10 pm
DSM
-
ROA
10h 10m
2 stops
$349United Airlines
Tue, Apr 28 - Sat, May 2
Delta Logo
6:00 am - 10:14 am
ROA
-
DSM
5h 14m
1 stop
Delta Logo
6:30 pm - 11:49 pm
DSM
-
ROA
4h 19m
1 stop
$354Delta
Tue, Jul 28 - Mon, Aug 3
United Airlines Logo
10:48 am - 2:25 pm
ROA
-
DSM
4h 37m
1 stop
United Airlines Logo
6:15 am - 1:34 pm
DSM
-
ROA
6h 19m
1 stop
$373United Airlines
Tue, Apr 28 - Sat, May 2
United Airlines Logo
8:37 am - 2:25 pm
ROA
-
DSM
6h 48m
1 stop
United Airlines Logo
1:35 pm - 11:44 pm
DSM
-
ROA
9h 09m
2 stops
$378United Airlines
Tue, Apr 28 - Sat, May 2

American Airlines flights from Roanoke to Des Moines

Our best American Airlines deals on Roanoke to Des Moines flight tickets
American Airlines
Apr 24
ROA7:28 amRoanoke
5h 02m
1 stop
DSM11:30 amDes Moines
Apr 27
DSM5:01 pmDes Moines
6h 09m
1 stop
ROA12:10 amRoanoke
$269
American Airlines
Apr 24
ROA7:28 amRoanoke
7h 18m
1 stop
DSM1:46 pmDes Moines
Apr 27
DSM3:00 pmDes Moines
6h 26m
1 stop
ROA10:26 pmRoanoke
$289
American Airlines
Apr 2
ROA7:05 amRoanoke
7h 02m
1 stop
DSM1:07 pmDes Moines
Apr 5
DSM6:40 amDes Moines
16h 19m
1 stop
ROA11:59 pmRoanoke
$312

Delta flights from Roanoke to Des Moines

Our best Delta deals on Roanoke to Des Moines flight tickets
Delta
Jul 28
ROA6:00 amRoanoke
5h 14m
1 stop
DSM10:14 amDes Moines
Aug 5
DSM6:30 pmDes Moines
4h 19m
1 stop
ROA11:49 pmRoanoke
$304
Delta
Jul 28
ROA6:00 amRoanoke
5h 14m
1 stop
DSM10:14 amDes Moines
Aug 3
DSM6:30 pmDes Moines
4h 19m
1 stop
ROA11:49 pmRoanoke
$354
Delta
Jul 27
ROA7:50 pmRoanoke
15h 25m
2 stops
DSM10:15 amDes Moines
Aug 1
DSM6:30 pmDes Moines
4h 19m
1 stop
ROA11:49 pmRoanoke
$388

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Roanoke to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 4/24

7:28 am-11:30 am

1 stop5h 02m

Des Moines

Mon 4/27

5:01 pm-12:10 am

1 stop6h 09m

$269

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 4/24

7:28 am-1:46 pm

1 stop7h 18m

Des Moines

Mon 4/27

3:00 pm-10:26 pm

1 stop6h 26m

$289

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 7/28

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Wed 8/5

6:30 pm-11:49 pm

1 stop4h 19m

$304

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Thu 4/2

7:05 am-1:07 pm

1 stop7h 02m

Des Moines

Sun 4/5

6:40 am-11:59 pm

1 stop16h 19m

$312

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 4/28

5:40 pm-10:59 pm

1 stop6h 19m

Des Moines

Sat 5/2

1:05 pm-8:54 pm

1 stop6h 49m

$339

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 4/28

5:40 pm-10:59 pm

1 stop6h 19m

Des Moines

Sat 5/2

6:15 am-7:10 pm

2 stops11h 55m

$344

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 4/28

8:37 am-4:10 pm

2 stops8h 33m

Des Moines

Sat 5/2

8:00 am-7:10 pm

2 stops10h 10m

$349

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 7/28

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Mon 8/3

6:30 pm-11:49 pm

1 stop4h 19m

$354

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 4/28

10:48 am-2:25 pm

1 stop4h 37m

Des Moines

Sat 5/2

6:15 am-1:34 pm

1 stop6h 19m

$373

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 4/28

8:37 am-2:25 pm

1 stop6h 48m

Des Moines

Sat 5/2

1:35 pm-11:44 pm

2 stops9h 09m

$378

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Roanoke to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Roanoke to Des Moines?

Allegiant Air and United Airlines are the most popular carriers operating from Roanoke to Des Moines

What airlines fly to Des Moines?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Des Moines from Roanoke according to our data. American Airlines is the first choice among our users, with 65% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Roanoke to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Des Moines (ROA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Des Moines

Fastest flight time

4h 50m

Direct flights

None
The fastest flight from Roanoke to Des Moines takes 4h 50m
There are no direct flights from Roanoke to Des Moines. There are no popular flight routes from Roanoke to Des Moines.
Search flight deals

  • How far is Roanoke to Des Moines by plane?

    The distance between Roanoke and Des Moines is about 787.3 mi. Typically, this will take 4h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?

    Prices for flights from Roanoke Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?

  • How old do you have to be to fly from Roanoke Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Roanoke to Des Moines?

Best airlines flying from Roanoke to Des Moines

Compare and see reviews for airlines that fly from Roanoke to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,342 reviews
Search United Airlines flights
American AirlinesPriceFrom $292Free CancellationRating
7.2
11,339 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Roanoke.

I’m not ready to book a flight from Roanoke to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Roanoke and alert you when they change.

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