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Cheap flights from Roanoke to Des Moines from $269

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Des Moines departing on 7/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Roanoke to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 10:18 am
ROA
-
DSM
5h 18m
1 stop
Delta Logo
6:30 pm - 11:50 pm
DSM
-
ROA
4h 20m
1 stop
$309Delta
Wed, Oct 7 - Tue, Oct 13
American Airlines Logo
7:58 pm - 12:12 am
ROA
-
DSM
5h 14m
1 stop
American Airlines Logo
1:41 pm - 9:20 pm
DSM
-
ROA
6h 39m
1 stop
$324American Airlines
Tue, Jun 30 - Tue, Jul 7
American Airlines Logo
7:00 am - 12:52 pm
ROA
-
DSM
6h 52m
1 stop
American Airlines Logo
1:35 pm - 11:59 pm
DSM
-
ROA
9h 24m
2 stops
$329American Airlines
Tue, Jun 30 - Tue, Jul 7
American Airlines Logo
11:10 am - 7:35 pm
ROA
-
DSM
9h 25m
2 stops
American Airlines Logo
5:00 am - 4:14 pm
DSM
-
ROA
10h 14m
2 stops
$335American Airlines
Tue, Jun 30 - Tue, Jul 7
Delta Logo
11:20 am - 5:42 pm
ROA
-
DSM
7h 22m
1 stop
Delta Logo
6:30 pm - 11:50 pm
DSM
-
ROA
4h 20m
1 stop
$364Delta
Fri, Oct 9 - Mon, Oct 12
United Airlines Logo
6:49 am - 12:34 pm
ROA
-
DSM
6h 45m
1 stop
United Airlines Logo
3:11 pm - 10:59 pm
DSM
-
ROA
6h 48m
1 stop
$389United Airlines
Wed, Sep 30 - Sat, Oct 3
United Airlines Logo
6:49 am - 12:34 pm
ROA
-
DSM
6h 45m
1 stop
United Airlines Logo
6:00 am - 2:19 pm
DSM
-
ROA
7h 19m
2 stops
$394United Airlines
Wed, Sep 30 - Sat, Oct 3
United Airlines Logo
6:15 am - 12:34 pm
ROA
-
DSM
7h 19m
2 stops
United Airlines Logo
6:00 am - 2:19 pm
DSM
-
ROA
7h 19m
2 stops
$399United Airlines
Wed, Sep 30 - Sat, Oct 3
American Airlines Logo
4:42 pm - 12:35 am
ROA
-
DSM
8h 53m
2 stops
American Airlines Logo
7:04 am - 2:42 pm
DSM
-
ROA
6h 38m
1 stop
$404American Airlines
Wed, Jul 1 - Sun, Jul 5
Delta Logo
6:00 am - 10:18 am
ROA
-
DSM
5h 18m
1 stop
Delta Logo
6:30 pm - 11:50 pm
DSM
-
ROA
4h 20m
1 stop
$414Delta
Tue, Oct 6 - Mon, Oct 12

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United Airlines flights from Roanoke to Des Moines

Our best United Airlines deals on Roanoke to Des Moines flight tickets
United Airlines
Sep 30
ROA6:49 amRoanoke
6h 45m
1 stop
DSM12:34 pmDes Moines
Oct 3
DSM3:11 pmDes Moines
6h 48m
1 stop
ROA10:59 pmRoanoke
$389
United Airlines
Sep 30
ROA6:49 amRoanoke
6h 45m
1 stop
DSM12:34 pmDes Moines
Oct 3
DSM6:00 amDes Moines
7h 19m
2 stops
ROA2:19 pmRoanoke
$394
United Airlines
Sep 30
ROA6:15 amRoanoke
7h 19m
2 stops
DSM12:34 pmDes Moines
Oct 3
DSM6:00 amDes Moines
7h 19m
2 stops
ROA2:19 pmRoanoke
$399

Delta flights from Roanoke to Des Moines

Our best Delta deals on Roanoke to Des Moines flight tickets
Delta
Oct 7
ROA6:00 amRoanoke
5h 18m
1 stop
DSM10:18 amDes Moines
Oct 13
DSM6:30 pmDes Moines
4h 20m
1 stop
ROA11:50 pmRoanoke
$309
Delta
Oct 9
ROA11:20 amRoanoke
7h 22m
1 stop
DSM5:42 pmDes Moines
Oct 12
DSM6:30 pmDes Moines
4h 20m
1 stop
ROA11:50 pmRoanoke
$364
Delta
Oct 6
ROA6:00 amRoanoke
5h 18m
1 stop
DSM10:18 amDes Moines
Oct 12
DSM6:30 pmDes Moines
4h 20m
1 stop
ROA11:50 pmRoanoke
$414

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from Roanoke to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 10/7

6:00 am-10:18 am

1 stop5h 18m

Des Moines

Tue 10/13

6:30 pm-11:50 pm

1 stop4h 20m

$309

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 6/30

7:58 pm-12:12 am

1 stop5h 14m

Des Moines

Tue 7/7

1:41 pm-9:20 pm

1 stop6h 39m

$324

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 6/30

7:00 am-12:52 pm

1 stop6h 52m

Des Moines

Tue 7/7

1:35 pm-11:59 pm

2 stops9h 24m

$329

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 6/30

11:10 am-7:35 pm

2 stops9h 25m

Des Moines

Tue 7/7

5:00 am-4:14 pm

2 stops10h 14m

$335

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 10/9

11:20 am-5:42 pm

1 stop7h 22m

Des Moines

Mon 10/12

6:30 pm-11:50 pm

1 stop4h 20m

$364

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 9/30

6:49 am-12:34 pm

1 stop6h 45m

Des Moines

Sat 10/3

3:11 pm-10:59 pm

1 stop6h 48m

$389

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 9/30

6:49 am-12:34 pm

1 stop6h 45m

Des Moines

Sat 10/3

6:00 am-2:19 pm

2 stops7h 19m

$394

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 9/30

6:15 am-12:34 pm

2 stops7h 19m

Des Moines

Sat 10/3

6:00 am-2:19 pm

2 stops7h 19m

$399

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 7/1

4:42 pm-12:35 am

2 stops8h 53m

Des Moines

Sun 7/5

7:04 am-2:42 pm

1 stop6h 38m

$404

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Tue 10/6

6:00 am-10:18 am

1 stop5h 18m

Des Moines

Mon 10/12

6:30 pm-11:50 pm

1 stop4h 20m

$414

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Roanoke to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then October is your next best option. Flight prices from Roanoke to Des Moines during October average around $318.

When to book flights from Roanoke to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Des Moines (ROA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Des Moines

Fastest flight time

4h 39m

Direct flights

None
The fastest flight from Roanoke to Des Moines takes 4h 39m
There are no direct flights from Roanoke to Des Moines. There are no popular flight routes from Roanoke to Des Moines.
Search flight deals

Frequently asked questions about flying from Roanoke to Des Moines

  • How far is Roanoke to Des Moines by plane?

    The distance between Roanoke and Des Moines is about 787.3 mi. Typically, this will take 4h 39m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?

    Prices for flights from Roanoke Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?

  • How old do you have to be to fly from Roanoke Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Roanoke to Des Moines?

Best airlines flying from Roanoke to Des Moines

Compare and see reviews for airlines that fly from Roanoke to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,859 reviews
Search United Airlines flights
American AirlinesPriceFrom $293Free CancellationRating
7.1
11,686 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Osceola
Urbandale
Newton
Johnston
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Roanoke.

I’m not ready to book a flight from Roanoke to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Roanoke and alert you when they change.

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