What airlines fly to Des Moines?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Des Moines from Roanoke according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between Roanoke and Des Moines?

Chicago (ORD) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from Roanoke to Des Moines?

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 4h 44m.

Which layover airport offers the lowest fares from Roanoke to Des Moines?

Flights via Chicago (ORD) offer the lowest average round-trip price of $544.

Which layover airport has the shortest connection time from Roanoke to Des Moines?

Chicago (ORD) has the shortest average layover time for this route: 1h 07m.

When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?

Prices for flights from Roanoke Airport to Des Moines Airport were last updated today.

How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?

As of September 2025, there are 3 operators available to choose from for flights from Roanoke Airport to Des Moines Airport.

How old do you have to be to fly from Roanoke Airport to Des Moines Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$206 Cheap Flights from Roanoke to Des Moines in 2025/26

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Find the cheapest flights from Roanoke to Des Moines

Round-trip

One-way

Cheap round-trip flights

7:05 am - 2:28 pmROA-DSM

8h 23m1 stop

6:30 pm - 12:25 amDSM-ROA

4h 55m1 stop

$314Delta

Find Deal

Fri, Sep 26 - Sun, Sep 28

7:03 pm - 11:06 pmROA-DSM

5h 03m1 stop

7:08 am - 5:20 pmDSM-ROA

9h 12m2 stops

$527American Airlines

Find Deal

Fri, Sep 26 - Sun, Sep 28

2:24 pm - 11:06 pmROA-DSM

9h 42m2 stops

7:08 am - 5:20 pmDSM-ROA

9h 12m2 stops

$824American Airlines

Find Deal

Fri, Sep 26 - Sun, Sep 28

American Airlines flights from Roanoke to Des Moines

Our best American Airlines deals on Roanoke to Des Moines flight tickets

American Airlines

Sep 26

ROA7:03 pmRoanoke

5h 03m

1 stop

DSM11:06 pmDes Moines

Sep 28

DSM7:08 amDes Moines

9h 12m

2 stops

ROA5:20 pmRoanoke

$527

Find similar

American Airlines

Sep 26

ROA2:24 pmRoanoke

9h 42m

2 stops

DSM11:06 pmDes Moines

Sep 28

DSM7:08 amDes Moines

9h 12m

2 stops

ROA5:20 pmRoanoke

$824

Find similar

Fly from

Fly to

Route

Depart

Return

Price

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 9/26

7:05 am-2:28 pm

1 stop8h 23m

Des Moines

Sun 9/28

6:30 pm-12:25 am

1 stop4h 55m

$314

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 9/26

7:03 pm-11:06 pm

1 stop5h 03m

Des Moines

Sun 9/28

7:08 am-5:20 pm

2 stops9h 12m

$527

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 9/26

2:24 pm-11:06 pm

2 stops9h 42m

Des Moines

Sun 9/28

7:08 am-5:20 pm

2 stops9h 12m

$824

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Roanoke to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Roanoke to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $248. Flights from Roanoke to Des Moines on a Sunday will generally be more expensive and average around $545. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Roanoke to Des Moines at noon for as low as $306. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $377. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Roanoke to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Roanoke to Des Moines (ROA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Des Moines

Direct flights	None

There are no direct flights from Roanoke to Des Moines. There are no popular flight routes from Roanoke to Des Moines.

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How far is Roanoke to Des Moines by plane?
The distance between Roanoke and Des Moines is about 787.3 mi. Typically, this will take 5h 03m by plane in normal conditions.
When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?
Prices for flights from Roanoke Airport to Des Moines Airport were last updated today.
How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?
As of September 2025, there are 3 operators available to choose from for flights from Roanoke Airport to Des Moines Airport.
How old do you have to be to fly from Roanoke Airport to Des Moines Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Roanoke to Des Moines?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Roanoke to Des Moines is American Airlines (58% of total bookings). The next most popular airlines are United Airlines (23%) and Delta (19%).

Best airlines flying from Roanoke to Des Moines

Compare and see reviews for airlines that fly from Roanoke to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $208	Free Cancellation	Rating 7.9 7,956 reviews	Search Delta flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 8,931 reviews	Search United Airlines flights
American Airlines	PriceFrom $292	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights

West Des Moines

Ames

Ankeny

Altoona

Clive

Urbandale

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Roanoke.

I’m not ready to book a flight from Roanoke to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Roanoke and alert you when they change.

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Cheap flights from Roanoke to Des Moines from $314

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Des Moines departing on 9/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Roanoke to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

What is the cheapest time of day to depart on your flight to Des Moines?

What airlines fly to Des Moines?

Which airport is the most popular layover for flights between Roanoke and Des Moines?

Chicago (ORD) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Roanoke to Des Moines?

Flights via Chicago (ORD) offer the lowest average round-trip price of $544.

Which layover airport has the shortest travel time from Roanoke to Des Moines?

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 4h 44m.

Which layover airport has the shortest connection time from Roanoke to Des Moines?

Chicago (ORD) has the shortest average layover time for this route: 1h 07m.

When to book flights from Roanoke to Des Moines

Cheap Roanoke to Des Moines (ROA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Des Moines

Direct flights

How far is Roanoke to Des Moines by plane?

When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?

How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?

How old do you have to be to fly from Roanoke Airport to Des Moines Airport?

What documentation or ID do you need to fly to Des Moines Airport?

What is the most popular airline from Roanoke to Des Moines?

Best airlines flying from Roanoke to Des Moines

Compare and see reviews for airlines that fly from Roanoke to Des Moines with momondo

Traveling to a place near Des Moines?

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Des Moines?

Can I find flights from Roanoke to Des Moines with flexible booking policies on momondo?

How can momondo help me find flights from Roanoke to Des Moines?

I’m not ready to book a flight from Roanoke to Des Moines right now. Can momondo alert me if prices change?

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Iowa