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Cheap flights from Roanoke to Des Moines from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Des Moines departing on 5/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Roanoke to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 10:45 am
ROA
-
DSM
5h 45m
1 stop
Delta Logo
6:38 pm - 12:25 am
DSM
-
ROA
4h 47m
1 stop
$329Delta
Wed, Aug 5 - Sun, Aug 9
United Airlines Logo
5:42 pm - 9:23 pm
ROA
-
DSM
4h 41m
1 stop
United Airlines Logo
3:20 pm - 8:54 pm
DSM
-
ROA
4h 34m
1 stop
$339United Airlines
Fri, May 1 - Sat, May 2
United Airlines Logo
5:42 pm - 9:23 pm
ROA
-
DSM
4h 41m
1 stop
United Airlines Logo
10:02 am - 7:10 pm
DSM
-
ROA
8h 08m
2 stops
$344United Airlines
Fri, May 1 - Sat, May 2
Delta Logo
6:00 am - 11:08 am
ROA
-
DSM
6h 08m
1 stop
Delta Logo
6:39 pm - 12:29 am
DSM
-
ROA
4h 50m
1 stop
$374Delta
Sun, May 31 - Sun, Jun 7
United Airlines Logo
6:15 am - 12:30 pm
ROA
-
DSM
7h 15m
2 stops
United Airlines Logo
6:15 am - 2:18 pm
DSM
-
ROA
7h 03m
2 stops
$383United Airlines
Wed, Sep 30 - Tue, Oct 6
American Airlines Logo
6:00 am - 12:37 pm
ROA
-
DSM
7h 37m
1 stop
American Airlines Logo
6:00 am - 2:00 pm
DSM
-
ROA
7h 00m
1 stop
$388American Airlines
Wed, Aug 5 - Sun, Aug 9
United Airlines Logo
7:00 am - 10:20 am
ROA
-
DSM
4h 20m
1 stop
United Airlines Logo
11:33 am - 11:43 pm
DSM
-
ROA
11h 10m
2 stops
$414United Airlines
Wed, Sep 30 - Tue, Oct 6
Delta Logo
6:00 am - 11:08 am
ROA
-
DSM
6h 08m
1 stop
Delta Logo
6:41 pm - 12:34 am
DSM
-
ROA
4h 53m
1 stop
$464Delta
Sat, May 16 - Tue, May 19
United Airlines Logo
6:45 am - 10:37 am
ROA
-
DSM
4h 52m
1 stop
United Airlines Logo
10:02 am - 7:10 pm
DSM
-
ROA
8h 08m
2 stops
$481United Airlines
Sat, May 16 - Tue, May 19
United Airlines Logo
2:09 pm - 11:44 pm
ROA
-
DSM
10h 35m
2 stops
United Airlines Logo
1:35 pm - 11:44 pm
DSM
-
ROA
9h 09m
2 stops
$499United Airlines
Fri, May 1 - Sat, May 2

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Delta flights from Roanoke to Des Moines

Our best Delta deals on Roanoke to Des Moines flight tickets
Delta
Aug 5
ROA6:00 amRoanoke
5h 45m
1 stop
DSM10:45 amDes Moines
Aug 9
DSM6:38 pmDes Moines
4h 47m
1 stop
ROA12:25 amRoanoke
$329
Delta
May 31
ROA6:00 amRoanoke
6h 08m
1 stop
DSM11:08 amDes Moines
Jun 7
DSM6:39 pmDes Moines
4h 50m
1 stop
ROA12:29 amRoanoke
$374
Delta
May 16
ROA6:00 amRoanoke
6h 08m
1 stop
DSM11:08 amDes Moines
May 19
DSM6:41 pmDes Moines
4h 53m
1 stop
ROA12:34 amRoanoke
$464

American Airlines flights from Roanoke to Des Moines

Our best American Airlines deals on Roanoke to Des Moines flight tickets
American Airlines
Aug 5
ROA6:00 amRoanoke
7h 37m
1 stop
DSM12:37 pmDes Moines
Aug 9
DSM6:00 amDes Moines
7h 00m
1 stop
ROA2:00 pmRoanoke
$388
American Airlines
Aug 5
ROA2:23 pmRoanoke
10h 03m
2 stops
DSM11:26 pmDes Moines
Aug 9
DSM1:07 pmDes Moines
6h 23m
1 stop
ROA8:30 pmRoanoke
$533

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 20, 2026.
Use the filters below to find and compare flights from Roanoke to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 8/5

6:00 am-10:45 am

1 stop5h 45m

Des Moines

Sun 8/9

6:38 pm-12:25 am

1 stop4h 47m

$329
Quickest round-trip

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 5/1

5:42 pm-9:23 pm

1 stop4h 41m

Des Moines

Sat 5/2

3:20 pm-8:54 pm

1 stop4h 34m

$339

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 5/1

5:42 pm-9:23 pm

1 stop4h 41m

Des Moines

Sat 5/2

10:02 am-7:10 pm

2 stops8h 08m

$344

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Sun 5/31

6:00 am-11:08 am

1 stop6h 08m

Des Moines

Sun 6/7

6:39 pm-12:29 am

1 stop4h 50m

$374

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 9/30

6:15 am-12:30 pm

2 stops7h 15m

Des Moines

Tue 10/6

6:15 am-2:18 pm

2 stops7h 03m

$383

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 8/5

6:00 am-12:37 pm

1 stop7h 37m

Des Moines

Sun 8/9

6:00 am-2:00 pm

1 stop7h 00m

$388

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Wed 9/30

7:00 am-10:20 am

1 stop4h 20m

Des Moines

Tue 10/6

11:33 am-11:43 pm

2 stops11h 10m

$414

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Sat 5/16

6:00 am-11:08 am

1 stop6h 08m

Des Moines

Tue 5/19

6:41 pm-12:34 am

1 stop4h 53m

$464

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Sat 5/16

6:45 am-10:37 am

1 stop4h 52m

Des Moines

Tue 5/19

10:02 am-7:10 pm

2 stops8h 08m

$481

RoanokeDes Moines

ROA - DSM

ROADSM

Roanoke

Fri 5/1

2:09 pm-11:44 pm

2 stops10h 35m

Des Moines

Sat 5/2

1:35 pm-11:44 pm

2 stops9h 09m

$499

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Roanoke to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Roanoke and Des Moines?

When to book flights from Roanoke to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Des Moines (ROA to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Des Moines

Fastest flight time

5h 14m

Direct flights

None
The fastest flight from Roanoke to Des Moines takes 5h 14m
There are no direct flights from Roanoke to Des Moines. There are no popular flight routes from Roanoke to Des Moines.
Search flight deals

Frequently asked questions about flying from Roanoke to Des Moines

  • How far is Roanoke to Des Moines by plane?

    The distance between Roanoke and Des Moines is about 787.3 mi. Typically, this will take 5h 14m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to Des Moines Airport?

    Prices for flights from Roanoke Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Des Moines Airport?

  • How old do you have to be to fly from Roanoke Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Roanoke to Des Moines?

Best airlines flying from Roanoke to Des Moines

Compare and see reviews for airlines that fly from Roanoke to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,607 reviews
Search United Airlines flights
American AirlinesPriceFrom $292Free CancellationRating
7.1
11,625 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Roanoke.

I’m not ready to book a flight from Roanoke to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Roanoke and alert you when they change.

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