What is the cheapest airline that flies from Panama to South Carolina?

Delta, United Airlines, and American Airlines are the most popular carriers operating from Panama to South Carolina

When did momondo last update prices for flights from Panama to South Carolina?

Prices for flights from Panama to South Carolina refresh daily.

How many operators does momondo search for flights from Panama to South Carolina?

As of June 2026, there are 2 operators available to choose from for flights from Panama to South Carolina.

How old do you have to be to fly from Panama to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$270 Cheap Flights from Panama to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama to South Carolina

Round-trip

One-way

Last minute

Recent round-trip flight deals from Panama to South Carolina

Enter your travel dates to find the best prices.

5:55 pm - 5:12 pm

PTY

CLT

22h 17m

2 stops

6:48 pm - 8:30 am

CLT

PTY

14h 42m

1 stop

$521Multiple Airlines

Wed, Jul 29 - Tue, Aug 4

5:55 pm - 5:12 pm

PTY

CLT

22h 17m

2 stops

4:56 pm - 8:30 am

CLT

PTY

16h 34m

1 stop

$522Multiple Airlines

Tue, Aug 4 - Fri, Aug 28

2:21 pm - 11:57 pm

PTY

CLT

8h 36m

1 stop

6:55 am - 12:56 pm

CLT

PTY

7h 01m

1 stop

$551Delta

Thu, Sep 10 - Mon, Sep 14

3:35 pm - 7:03 am

PTY

CLT

14h 28m

1 stop

10:45 pm - 1:36 pm

CLT

PTY

14h 51m

1 stop

$560American Airlines

Fri, Oct 30 - Mon, Nov 9

10:00 am - 10:11 pm

PTY

CHS

11h 11m

1 stop

11:05 am - 7:31 pm

CHS

PTY

9h 26m

1 stop

$562United Airlines

Tue, Sep 22 - Tue, Sep 29

3:35 pm - 6:26 am

PTY

CLT

13h 51m

2 stops

10:45 pm - 1:36 pm

CLT

PTY

14h 51m

1 stop

$564American Airlines

Fri, Oct 30 - Mon, Nov 9

2:43 pm - 8:04 am

PTY

CLT

17h 21m

1 stop

5:15 am - 1:36 pm

CLT

PTY

8h 21m

1 stop

$570American Airlines

Fri, Nov 6 - Tue, Nov 10

3:30 pm - 9:58 pm

PTY

GSP

29h 28m

1 stop

7:47 pm - 7:31 pm

GSP

PTY

24h 44m

2 stops

$588United Airlines

Thu, Aug 13 - Mon, Aug 17

3:30 pm - 11:55 pm

PTY

AGS

8h 25m

1 stop

7:00 am - 2:05 pm

AGS

PTY

7h 05m

1 stop

$630Delta

Wed, Nov 11 - Sat, Nov 14

10:00 am - 10:15 pm

PTY

CHS

11h 15m

1 stop

6:50 am - 2:14 pm

CHS

PTY

8h 24m

1 stop

$694Copa Airlines

Mon, Jul 6 - Tue, Jul 14

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Delta flights from Panama to South Carolina

Our best Delta deals on Panama to South Carolina flight tickets

Delta

Sep 10

PTY2:21 pmPanama City Tocumen Intl

8h 36m

1 stop

CLT11:57 pmCharlotte Douglas

Sep 14

CLT6:55 amCharlotte Douglas

7h 01m

1 stop

PTY12:56 pmPanama City Tocumen Intl

$551

Delta

Nov 11

PTY3:30 pmPanama City Tocumen Intl

8h 25m

1 stop

AGS11:55 pmAugusta Bush Field

Nov 14

AGS7:00 amAugusta Bush Field

7h 05m

1 stop

PTY2:05 pmPanama City Tocumen Intl

$630

Delta

Nov 22

PTY3:30 pmPanama City Tocumen Intl

17h 10m

1 stop

CLT8:40 amCharlotte Douglas

Nov 30

CLT6:45 amCharlotte Douglas

7h 20m

1 stop

PTY2:05 pmPanama City Tocumen Intl

$653

American Airlines flights from Panama to South Carolina

Our best American Airlines deals on Panama to South Carolina flight tickets

American Airlines

Oct 30

PTY3:35 pmPanama City Tocumen Intl

14h 28m

1 stop

CLT7:03 amCharlotte Douglas

Nov 9

CLT10:45 pmCharlotte Douglas

14h 51m

1 stop

PTY1:36 pmPanama City Tocumen Intl

$560

American Airlines

Oct 30

PTY3:35 pmPanama City Tocumen Intl

13h 51m

2 stops

CLT6:26 amCharlotte Douglas

Nov 9

CLT10:45 pmCharlotte Douglas

14h 51m

1 stop

PTY1:36 pmPanama City Tocumen Intl

$564

American Airlines

Nov 6

PTY2:43 pmPanama City Tocumen Intl

17h 21m

1 stop

CLT8:04 amCharlotte Douglas

Nov 10

CLT5:15 amCharlotte Douglas

8h 21m

1 stop

PTY1:36 pmPanama City Tocumen Intl

$570

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 7/29

5:55 pm-5:12 pm

2 stops22h 17m

Charlotte Douglas

Tue 8/4

6:48 pm-8:30 am

1 stop14h 42m

$521

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 8/4

5:55 pm-5:12 pm

2 stops22h 17m

Charlotte Douglas

Fri 8/28

4:56 pm-8:30 am

1 stop16h 34m

$522

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

2:21 pm-11:57 pm

1 stop8h 36m

Charlotte Douglas

Mon 9/14

6:55 am-12:56 pm

1 stop7h 01m

$551

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 10/30

3:35 pm-7:03 am

1 stop14h 28m

Charlotte Douglas

Mon 11/9

10:45 pm-1:36 pm

1 stop14h 51m

$560

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 9/22

10:00 am-10:11 pm

1 stop11h 11m

Charleston

Tue 9/29

11:05 am-7:31 pm

1 stop9h 26m

$562

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 10/30

3:35 pm-6:26 am

2 stops13h 51m

Charlotte Douglas

Mon 11/9

10:45 pm-1:36 pm

1 stop14h 51m

$564

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 11/6

2:43 pm-8:04 am

1 stop17h 21m

Charlotte Douglas

Tue 11/10

5:15 am-1:36 pm

1 stop8h 21m

$570

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 8/13

3:30 pm-9:58 pm

1 stop29h 28m

Greenville

Mon 8/17

7:47 pm-7:31 pm

2 stops24h 44m

$588

Quickest round-trip

Panama CityAugusta

PTY - AGS

PTYAGS

Panama City Tocumen Intl

Wed 11/11

3:30 pm-11:55 pm

1 stop8h 25m

Augusta Bush Field

Sat 11/14

7:00 am-2:05 pm

1 stop7h 05m

$630

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 7/6

10:00 am-10:15 pm

1 stop11h 15m

Charleston

Tue 7/14

6:50 am-2:14 pm

1 stop8h 24m

$694

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Panama is in December. Flight prices, which tend to average around $148, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to South Carolina from Panama during February instead. Flights to South Carolina in February, while not as cheap as those in December, still average around $158.

Can stopping save me money on Panama to South Carolina flights?

You could potentially save up to 23% on your flight if you consider stops on a Panama to South Carolina flight.

Cheap Panama to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to South Carolina

Fastest flight time	8h 23m
Direct flights	None

The fastest flight from Panama to South Carolina takes 8h 23m

There are no direct flights from Panama to South Carolina. There are no popular flight routes from Panama to South Carolina.

Search flight deals

Frequently asked questions about flying from Panama to South Carolina

When did momondo last update prices for flights from Panama to South Carolina?
Prices for flights from Panama to South Carolina refresh daily.
How many operators does momondo search for flights from Panama to South Carolina?
As of June 2026, there are 2 operators available to choose from for flights from Panama to South Carolina.
How old do you have to be to fly from Panama to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama to South Carolina

Compare and see reviews for airlines that fly from Panama to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $397	Free Cancellation	Rating 7.1 11,644 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama to South Carolina for you.

Can I find flights from Panama to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama to South Carolina.

I’m not ready to book a flight from Panama to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.