What is the cheapest airline that flies from Panama to South Carolina?

American Airlines, United Airlines, and Delta are the most popular carriers operating from Panama to South Carolina

When did momondo last update prices for flights from Panama to South Carolina?

Prices for flights from Panama to South Carolina refresh daily.

How many operators does momondo search for flights from Panama to South Carolina?

As of December 2025, there are 2 operators available to choose from for flights from Panama to South Carolina.

How old do you have to be to fly from Panama to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$222 Cheap Flights from Panama to South Carolina in 2025/26

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0 bags

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Find the cheapest flights from Panama to South Carolina

Round-trip

One-way

Last minute

Recent round-trip flight deals from Panama to South Carolina

Enter your travel dates to find the best prices.

3:20 pm - 9:26 am

PTY

CHS

18h 06m1 stop

6:30 am - 1:55 pm

CHS

PTY

7h 25m1 stop

$372Delta

Thu, Feb 5 - Mon, Feb 9

2:27 pm - 11:34 am

PTY

CHS

21h 07m2 stops

7:03 pm - 1:40 pm

CHS

PTY

18h 37m2 stops

$390American Airlines

Tue, Feb 10 - Mon, Feb 23

3:15 pm - 10:35 pm

PTY

CHS

7h 20m1 stop

5:27 am - 1:50 pm

CHS

PTY

8h 23m1 stop

$396Delta

Thu, Feb 12 - Sun, Mar 1

2:27 pm - 2:25 pm

PTY

CHS

23h 58m2 stops

8:13 pm - 1:40 pm

CHS

PTY

17h 27m1 stop

$398American Airlines

Tue, Feb 10 - Mon, Feb 23

4:41 pm - 4:17 pm

PTY

CHS

23h 36m1 stop

5:10 pm - 5:07 pm

CHS

PTY

23h 57m1 stop

$402United Airlines

Tue, Feb 10 - Mon, Feb 23

2:40 pm - 11:29 am

PTY

CHS

20h 49m2 stops

7:03 pm - 3:15 pm

CHS

PTY

20h 12m2 stops

$409American Airlines

Thu, Feb 12 - Sun, Mar 1

2:55 am - 6:48 pm

PTY

CLT

15h 53m2 stops

7:00 am - 1:00 am

CLT

PTY

18h 00m2 stops

$410Multiple Airlines

Wed, Jan 28 - Thu, Feb 5

4:41 pm - 9:58 pm

PTY

CHS

29h 17m1 stop

5:10 pm - 2:45 pm

CHS

PTY

21h 35m1 stop

$415United Airlines

Fri, Feb 13 - Fri, Feb 20

10:20 am - 11:41 pm

PTY

MYR

37h 21m2 stops

10:33 am - 9:20 am

MYR

PTY

46h 47m2 stops

$1,822WestJet

Tue, Feb 3 - Thu, Feb 5

10:20 am - 6:05 pm

PTY

CAE

31h 45m2 stops

6:50 pm - 9:20 am

CAE

PTY

38h 30m2 stops

$1,970WestJet

Thu, Feb 12 - Thu, Feb 19

United Airlines flights from Panama to South Carolina

Our best United Airlines deals on Panama to South Carolina flight tickets

United Airlines

Feb 10

PTY4:41 pmPanama City Tocumen Intl

23h 36m

1 stop

CHS4:17 pmCharleston

Feb 23

CHS5:10 pmCharleston

23h 57m

1 stop

PTY5:07 pmPanama City Tocumen Intl

$402

Find similar

United Airlines

Feb 13

PTY4:41 pmPanama City Tocumen Intl

29h 17m

1 stop

CHS9:58 pmCharleston

Feb 20

CHS5:10 pmCharleston

21h 35m

1 stop

PTY2:45 pmPanama City Tocumen Intl

$415

Find similar

United Airlines

May 28

PTY7:55 amPanama City Tocumen Intl

12h 51m

1 stop

GSP9:46 pmGreenville

Jun 1

GSP5:15 pmGreenville

23h 57m

1 stop

PTY4:12 pmPanama City Tocumen Intl

$498

Find similar

American Airlines flights from Panama to South Carolina

Our best American Airlines deals on Panama to South Carolina flight tickets

American Airlines

Feb 10

PTY2:27 pmPanama City Tocumen Intl

21h 07m

2 stops

CHS11:34 amCharleston

Feb 23

CHS7:03 pmCharleston

18h 37m

2 stops

PTY1:40 pmPanama City Tocumen Intl

$390

Find similar

American Airlines

Feb 10

PTY2:27 pmPanama City Tocumen Intl

23h 58m

2 stops

CHS2:25 pmCharleston

Feb 23

CHS8:13 pmCharleston

17h 27m

1 stop

PTY1:40 pmPanama City Tocumen Intl

$398

Find similar

American Airlines

Feb 12

PTY2:40 pmPanama City Tocumen Intl

20h 49m

2 stops

CHS11:29 amCharleston

Mar 1

CHS7:03 pmCharleston

20h 12m

2 stops

PTY3:15 pmPanama City Tocumen Intl

$409

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 2/5

3:20 pm-9:26 am

1 stop18h 06m

Charleston

Mon 2/9

6:30 am-1:55 pm

1 stop7h 25m

$372

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/10

2:27 pm-11:34 am

2 stops21h 07m

Charleston

Mon 2/23

7:03 pm-1:40 pm

2 stops18h 37m

$390

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 2/12

3:15 pm-10:35 pm

1 stop7h 20m

Charleston

Sun 3/1

5:27 am-1:50 pm

1 stop8h 23m

$396

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/10

2:27 pm-2:25 pm

2 stops23h 58m

Charleston

Mon 2/23

8:13 pm-1:40 pm

1 stop17h 27m

$398

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/10

4:41 pm-4:17 pm

1 stop23h 36m

Charleston

Mon 2/23

5:10 pm-5:07 pm

1 stop23h 57m

$402

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 2/12

2:40 pm-11:29 am

2 stops20h 49m

Charleston

Sun 3/1

7:03 pm-3:15 pm

2 stops20h 12m

$409

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 1/28

2:55 am-6:48 pm

2 stops15h 53m

Charlotte Douglas

Thu 2/5

7:00 am-1:00 am

2 stops18h 00m

$410

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 2/13

4:41 pm-9:58 pm

1 stop29h 17m

Charleston

Fri 2/20

5:10 pm-2:45 pm

1 stop21h 35m

$415

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Tue 2/3

10:20 am-11:41 pm

2 stops37h 21m

Myrtle Beach Intl

Thu 2/5

10:33 am-9:20 am

2 stops46h 47m

$1,822

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Thu 2/12

10:20 am-6:05 pm

2 stops31h 45m

Columbia Metropolitan

Thu 2/19

6:50 pm-9:20 am

2 stops38h 30m

$1,970

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Can stopping save me money on Panama to South Carolina flights?

You could potentially save up to 20% on your flight if you consider stops on a Panama to South Carolina flight.

Cheap Panama to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to South Carolina

Fastest flight time	8h 18m
Direct flights	None

The fastest flight from Panama to South Carolina takes 8h 18m

There are no direct flights from Panama to South Carolina. There are no popular flight routes from Panama to South Carolina.

Search flight deals

When did momondo last update prices for flights from Panama to South Carolina?
Prices for flights from Panama to South Carolina refresh daily.
How many operators does momondo search for flights from Panama to South Carolina?
As of December 2025, there are 2 operators available to choose from for flights from Panama to South Carolina.
How old do you have to be to fly from Panama to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Panama to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama to South Carolina for you.

Can I find flights from Panama to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama to South Carolina.

I’m not ready to book a flight from Panama to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.