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Cheap flights from Panama to South Carolina from $220

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to South Carolina departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama to South Carolina

Recent round-trip flight deals from Panama to South Carolina

Delta Logo
2:21 pm - 11:46 amPTY-CHS
20h 25m1 stop
Delta Logo
3:47 pm - 2:12 pmCHS-PTY
22h 25m1 stop
$396Delta
Find Deal
Tue, Oct 28 - Fri, Nov 28
American Airlines Logo
3:15 pm - 4:54 pmPTY-CHS
24h 39m2 stops
American Airlines Logo
9:00 am - 1:43 pmCHS-PTY
28h 43m2 stops
$404American Airlines
Find Deal
Wed, Oct 29 - Thu, Nov 27
Delta Logo
8:00 am - 8:17 pmPTY-CLT
12h 17m1 stop
Delta Logo
8:20 am - 8:00 pmCLT-PTY
11h 40m1 stop
$408Delta
Find Deal
Wed, Dec 24 - Wed, Dec 31
Delta Logo
2:21 pm - 1:25 pmPTY-CHS
22h 04m1 stop
Delta Logo
6:30 am - 2:12 pmCHS-PTY
7h 42m1 stop
$415Delta
Find Deal
Fri, Oct 31 - Fri, Nov 28
American Airlines Logo
2:53 pm - 8:21 amPTY-CLT
17h 28m2 stops
American Airlines Logo
6:20 am - 1:53 pmCLT-PTY
7h 33m1 stop
$431American Airlines
Find Deal
Wed, Dec 24 - Wed, Dec 31
Multiple Airlines Logo
9:33 pm - 12:56 pmPTY-CLT
14h 23m1 stop
Multiple Airlines Logo
1:51 pm - 8:37 pmCLT-PTY
7h 46m1 stop
$433Multiple Airlines
Find Deal
Thu, Oct 16 - Mon, Oct 20
American Airlines Logo
3:15 pm - 11:59 pmPTY-CHS
7h 44m1 stop
American Airlines Logo
6:00 am - 1:43 pmCHS-PTY
7h 43m1 stop
$442American Airlines
Find Deal
Wed, Oct 29 - Thu, Nov 27
Delta Logo
2:21 pm - 1:25 pmPTY-CHS
22h 04m1 stop
Delta Logo
5:25 am - 2:12 pmCHS-PTY
8h 47m1 stop
$449Delta
Find Deal
Tue, Oct 28 - Wed, Nov 26
United Airlines Logo
7:55 am - 9:59 pmPTY-CHS
13h 04m1 stop
United Airlines Logo
5:05 pm - 2:45 pmCHS-PTY
21h 40m1 stop
$467United Airlines
Find Deal
Wed, Oct 29 - Mon, Nov 24
United Airlines Logo
3:41 pm - 9:59 pmPTY-CHS
29h 18m1 stop
United Airlines Logo
5:05 pm - 7:38 pmCHS-PTY
26h 33m1 stop
$486United Airlines
Find Deal
Fri, Oct 31 - Mon, Nov 24

American Airlines flights from Panama to South Carolina

Our best American Airlines deals on Panama to South Carolina flight tickets
American Airlines
Oct 29
PTY3:15 pmPanama City Tocumen Intl
24h 39m
2 stops
CHS4:54 pmCharleston
Nov 27
CHS9:00 amCharleston
28h 43m
2 stops
PTY1:43 pmPanama City Tocumen Intl
$404
Find similar
American Airlines
Dec 24
PTY2:53 pmPanama City Tocumen Intl
17h 28m
2 stops
CLT8:21 amCharlotte Douglas
Dec 31
CLT6:20 amCharlotte Douglas
7h 33m
1 stop
PTY1:53 pmPanama City Tocumen Intl
$431
Find similar
American Airlines
Oct 29
PTY3:15 pmPanama City Tocumen Intl
7h 44m
1 stop
CHS11:59 pmCharleston
Nov 27
CHS6:00 amCharleston
7h 43m
1 stop
PTY1:43 pmPanama City Tocumen Intl
$442
Find similar

Delta flights from Panama to South Carolina

Our best Delta deals on Panama to South Carolina flight tickets
Delta
Oct 28
PTY2:21 pmPanama City Tocumen Intl
20h 25m
1 stop
CHS11:46 amCharleston
Nov 27
CHS10:40 amCharleston
27h 32m
1 stop
PTY2:12 pmPanama City Tocumen Intl
$396
Find similar
Delta
Dec 24
PTY8:00 amPanama City Tocumen Intl
12h 17m
1 stop
CLT8:17 pmCharlotte Douglas
Dec 31
CLT8:20 amCharlotte Douglas
11h 40m
1 stop
PTY8:00 pmPanama City Tocumen Intl
$408
Find similar
Delta
Oct 31
PTY2:21 pmPanama City Tocumen Intl
22h 04m
1 stop
CHS1:25 pmCharleston
Nov 28
CHS6:30 amCharleston
7h 42m
1 stop
PTY2:12 pmPanama City Tocumen Intl
$415
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 23, 2025.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 10/28

2:21 pm-11:46 am

1 stop20h 25m

Charleston

Fri 11/28

3:47 pm-2:12 pm

1 stop22h 25m

$396

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 10/29

3:15 pm-4:54 pm

2 stops24h 39m

Charleston

Thu 11/27

9:00 am-1:43 pm

2 stops28h 43m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/24

8:00 am-8:17 pm

1 stop12h 17m

Charlotte Douglas

Wed 12/31

8:20 am-8:00 pm

1 stop11h 40m

$408

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 10/31

2:21 pm-1:25 pm

1 stop22h 04m

Charleston

Fri 11/28

6:30 am-2:12 pm

1 stop7h 42m

$415

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/24

2:53 pm-8:21 am

2 stops17h 28m

Charlotte Douglas

Wed 12/31

6:20 am-1:53 pm

1 stop7h 33m

$431

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 10/16

9:33 pm-12:56 pm

1 stop14h 23m

Charlotte Douglas

Mon 10/20

1:51 pm-8:37 pm

1 stop7h 46m

$433

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 10/29

3:15 pm-11:59 pm

1 stop7h 44m

Charleston

Thu 11/27

6:00 am-1:43 pm

1 stop7h 43m

$442

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 10/28

2:21 pm-1:25 pm

1 stop22h 04m

Charleston

Wed 11/26

5:25 am-2:12 pm

1 stop8h 47m

$449

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 10/29

7:55 am-9:59 pm

1 stop13h 04m

Charleston

Mon 11/24

5:05 pm-2:45 pm

1 stop21h 40m

$467

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 10/31

3:41 pm-9:59 pm

1 stop29h 18m

Charleston

Mon 11/24

5:05 pm-7:38 pm

1 stop26h 33m

$486

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Panama to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $502. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $552.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Panama to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $469. Try not to purchase tickets in the afternoon because they tend to be around $554. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Panama to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to South Carolina

Direct flights

None
There are no direct flights from Panama to South Carolina. There are no popular flight routes from Panama to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Panama to South Carolina?

    Prices for flights from Panama to South Carolina refresh daily.

  • How many operators does momondo search for flights from Panama to South Carolina?

  • How old do you have to be to fly from Panama to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama to South Carolina

Compare and see reviews for airlines that fly from Panama to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $397Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama to South Carolina for you.

Can I find flights from Panama to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama to South Carolina.

I’m not ready to book a flight from Panama to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

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