What is the cheapest airline that flies from Panama to South Carolina?

American Airlines, Delta, and Copa Airlines are the most popular carriers operating from Panama to South Carolina

When did momondo last update prices for flights from Panama to South Carolina?

Prices for flights from Panama to South Carolina refresh daily.

How many operators does momondo search for flights from Panama to South Carolina?

As of April 2026, there are 3 operators available to choose from for flights from Panama to South Carolina.

How old do you have to be to fly from Panama to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$232 Cheap Flights from Panama to South Carolina in 2026

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Find the cheapest flights from Panama to South Carolina

Round-trip

One-way

Last minute

Recent round-trip flight deals from Panama to South Carolina

Enter your travel dates to find the best prices.

3:10 pm - 11:45 am

PTY

CLT

19h 35m

2 stops

6:30 am - 9:15 am

CLT

PTY

27h 45m

2 stops

$431Multiple Airlines

Wed, Apr 15 - Sun, Apr 19

10:10 am - 11:45 am

PTY

CLT

24h 35m

2 stops

6:30 am - 10:30 am

CLT

PTY

29h 00m

3 stops

$446Multiple Airlines

Wed, Apr 15 - Sun, Apr 19

2:21 pm - 11:57 pm

PTY

CLT

8h 36m

1 stop

6:45 am - 12:56 pm

CLT

PTY

7h 11m

1 stop

$465Delta

Thu, Sep 10 - Mon, Sep 14

2:15 pm - 10:56 pm

PTY

CHS

7h 41m

1 stop

6:15 am - 1:09 pm

CHS

PTY

7h 54m

1 stop

$476Delta

Mon, Jun 1 - Tue, Jun 16

3:40 pm - 6:27 am

PTY

CLT

13h 47m

2 stops

9:00 pm - 2:10 pm

CLT

PTY

18h 10m

1 stop

$477American Airlines

Thu, Sep 10 - Mon, Sep 14

3:40 pm - 6:27 am

PTY

CLT

13h 47m

2 stops

8:15 pm - 2:10 pm

CLT

PTY

18h 55m

1 stop

$478American Airlines

Thu, Sep 10 - Mon, Sep 14

10:10 am - 11:45 am

PTY

CLT

24h 35m

2 stops

6:49 pm - 12:35 am

CLT

PTY

30h 46m

2 stops

$479Multiple Airlines

Wed, Apr 29 - Wed, May 6

7:55 am - 10:15 pm

PTY

CHS

13h 20m

1 stop

6:50 am - 2:14 pm

CHS

PTY

8h 24m

1 stop

$495United Airlines

Mon, Jun 1 - Tue, Jun 16

10:00 am - 10:15 pm

PTY

CHS

11h 15m

1 stop

11:18 am - 7:31 pm

CHS

PTY

9h 13m

1 stop

$504United Airlines

Wed, May 27 - Wed, Jun 3

2:15 pm - 11:58 pm

PTY

MYR

8h 43m

1 stop

7:00 am - 12:59 pm

MYR

PTY

6h 59m

1 stop

$699JetBlue

Fri, Jun 5 - Sat, Jun 20

American Airlines flights from Panama to South Carolina

Our best American Airlines deals on Panama to South Carolina flight tickets

American Airlines

Sep 10

PTY3:40 pmPanama City Tocumen Intl

13h 47m

2 stops

CLT6:27 amCharlotte Douglas

Sep 14

CLT9:00 pmCharlotte Douglas

18h 10m

1 stop

PTY2:10 pmPanama City Tocumen Intl

$477

American Airlines

Sep 10

PTY3:40 pmPanama City Tocumen Intl

13h 47m

2 stops

CLT6:27 amCharlotte Douglas

Sep 14

CLT8:15 pmCharlotte Douglas

18h 55m

1 stop

PTY2:10 pmPanama City Tocumen Intl

$478

American Airlines

May 27

PTY1:14 pmPanama City Tocumen Intl

9h 45m

1 stop

CHS11:59 pmCharleston

Jun 3

CHS7:47 pmCharleston

17h 27m

2 stops

PTY12:14 pmPanama City Tocumen Intl

$494

United Airlines flights from Panama to South Carolina

Our best United Airlines deals on Panama to South Carolina flight tickets

United Airlines

Jun 1

PTY7:55 amPanama City Tocumen Intl

13h 20m

1 stop

CHS10:15 pmCharleston

Jun 16

CHS6:50 amCharleston

8h 24m

1 stop

PTY2:14 pmPanama City Tocumen Intl

$495

United Airlines

May 27

PTY10:00 amPanama City Tocumen Intl

11h 15m

1 stop

CHS10:15 pmCharleston

Jun 3

CHS11:18 amCharleston

9h 13m

1 stop

PTY7:31 pmPanama City Tocumen Intl

$504

United Airlines

May 27

PTY7:55 amPanama City Tocumen Intl

25h 13m

2 stops

CHS10:08 amCharleston

Jun 3

CHS10:00 amCharleston

10h 31m

2 stops

PTY7:31 pmPanama City Tocumen Intl

$509

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 4/15

3:10 pm-11:45 am

2 stops19h 35m

Charlotte Douglas

Sun 4/19

6:30 am-9:15 am

2 stops27h 45m

$431

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 4/15

10:10 am-11:45 am

2 stops24h 35m

Charlotte Douglas

Sun 4/19

6:30 am-10:30 am

3 stops29h 00m

$446

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

2:21 pm-11:57 pm

1 stop8h 36m

Charlotte Douglas

Mon 9/14

6:45 am-12:56 pm

1 stop7h 11m

$465

Quickest round-trip

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

2:15 pm-10:56 pm

1 stop7h 41m

Charleston

Tue 6/16

6:15 am-1:09 pm

1 stop7h 54m

$476

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

3:40 pm-6:27 am

2 stops13h 47m

Charlotte Douglas

Mon 9/14

9:00 pm-2:10 pm

1 stop18h 10m

$477

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

3:40 pm-6:27 am

2 stops13h 47m

Charlotte Douglas

Mon 9/14

8:15 pm-2:10 pm

1 stop18h 55m

$478

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 4/29

10:10 am-11:45 am

2 stops24h 35m

Charlotte Douglas

Wed 5/6

6:49 pm-12:35 am

2 stops30h 46m

$479

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

7:55 am-10:15 pm

1 stop13h 20m

Charleston

Tue 6/16

6:50 am-2:14 pm

1 stop8h 24m

$495

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

10:00 am-10:15 pm

1 stop11h 15m

Charleston

Wed 6/3

11:18 am-7:31 pm

1 stop9h 13m

$504

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Fri 6/5

2:15 pm-11:58 pm

1 stop8h 43m

Myrtle Beach Intl

Sat 6/20

7:00 am-12:59 pm

1 stop6h 59m

$699

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Panama is in December. Flight prices, which tend to average around $376, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to South Carolina from Panama during August instead. Flights to South Carolina in August, while not as cheap as those in December, still average around $395.

Can stopping save me money on Panama to South Carolina flights?

You could potentially save up to 15% on your flight if you consider stops on a Panama to South Carolina flight.

Cheap Panama to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to South Carolina

Fastest flight time	7h 41m
Direct flights	None

The fastest flight from Panama to South Carolina takes 7h 41m

There are no direct flights from Panama to South Carolina. There are no popular flight routes from Panama to South Carolina.

Search flight deals

Frequently asked questions about flying from Panama to South Carolina

When did momondo last update prices for flights from Panama to South Carolina?
Prices for flights from Panama to South Carolina refresh daily.
How many operators does momondo search for flights from Panama to South Carolina?
As of April 2026, there are 3 operators available to choose from for flights from Panama to South Carolina.
How old do you have to be to fly from Panama to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Panama to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama to South Carolina for you.

Can I find flights from Panama to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama to South Carolina.

I’m not ready to book a flight from Panama to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Panama to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.