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Cheap flights from Panama City to Santiago from $316

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Santiago departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City to Santiago (PTY-SCL)

Cheap round-trip flights

Logo
3:20 am - 2:50 pmPTY-SCL
33h 30m2 stops
Logo
12:55 am - 10:10 amSCL-PTY
11h 15m1 stop
$636
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Tue, Sep 23 - Sat, Sep 27
Logo
3:20 am - 12:35 pmPTY-SCL
32h 15m2 stops
Logo
12:55 am - 10:10 amSCL-PTY
11h 15m1 stop
$642
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Thu, Sep 4 - Sat, Sep 20
Logo
5:25 pm - 11:40 pmPTY-SCL
28h 15m2 stops
Logo
7:10 am - 4:30 pmSCL-PTY
11h 20m1 stop
$653
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Tue, Sep 16 - Tue, Sep 23
Avianca Logo
2:55 pm - 5:30 amPTY-SCL
12h 35m1 stop
Avianca Logo
7:35 am - 4:55 pmSCL-PTY
11h 20m1 stop
$658Avianca
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Fri, Oct 31 - Sun, Nov 16
Avianca Logo
2:55 am - 3:20 pmPTY-SCL
10h 25m1 stop
Avianca Logo
7:25 am - 4:55 pmSCL-PTY
11h 30m1 stop
$669Avianca
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Thu, Dec 18 - Tue, Jan 6
Avianca Logo
2:55 am - 3:20 pmPTY-SCL
10h 25m1 stop
Avianca Logo
7:25 am - 1:00 amSCL-PTY
19h 35m1 stop
$673Avianca
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Sun, Dec 21 - Sat, Dec 27
Copa Airlines Logo
7:11 pm - 3:43 amPTY-SCL
6h 32mnonstop
Copa Airlines Logo
3:23 am - 8:16 amSCL-PTY
6h 53mnonstop
$706Copa Airlines
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Sat, Nov 1 - Sun, Nov 9
Copa Airlines Logo
11:48 am - 8:21 pmPTY-SCL
6h 33mnonstop
Copa Airlines Logo
1:08 am - 6:00 amSCL-PTY
6h 52mnonstop
$722Copa Airlines
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Fri, Nov 28 - Sun, Nov 30
Copa Airlines Logo
11:48 am - 8:21 pmPTY-SCL
6h 33mnonstop
Copa Airlines Logo
3:23 am - 8:16 amSCL-PTY
6h 53mnonstop
$740Copa Airlines
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Fri, Nov 14 - Mon, Dec 1
Copa Airlines Logo
3:32 pm - 12:04 amPTY-SCL
6h 32mnonstop
Copa Airlines Logo
1:24 am - 6:16 amSCL-PTY
6h 52mnonstop
$749Copa Airlines
Find Deal
Mon, Sep 22 - Tue, Sep 30

Avianca flights from Panama City to Santiago

Our best Avianca deals on Panama City to Santiago flight tickets
Avianca
Oct 31
PTY2:55 pmPanama City Tocumen Intl
12h 35m
1 stop
SCL5:30 amSantiago Arturo Merino Benitez
Nov 16
SCL7:35 amSantiago Arturo Merino Benitez
11h 20m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$658
Find similar
Avianca
Dec 18
PTY2:55 amPanama City Tocumen Intl
10h 25m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
Jan 6
SCL7:25 amSantiago Arturo Merino Benitez
11h 30m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$669
Find similar
Avianca
Dec 21
PTY2:55 amPanama City Tocumen Intl
10h 25m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
Dec 27
SCL7:25 amSantiago Arturo Merino Benitez
19h 35m
1 stop
PTY1:00 amPanama City Tocumen Intl
$673
Find similar

Copa Airlines flights from Panama City to Santiago

Our best Copa Airlines deals on Panama City to Santiago flight tickets
Copa Airlines
Nov 1
PTY7:11 pmPanama City Tocumen Intl
6h 32m
SCL3:43 amSantiago Arturo Merino Benitez
Nov 9
SCL3:23 amSantiago Arturo Merino Benitez
6h 53m
PTY8:16 amPanama City Tocumen Intl
$706
Find similar
Copa Airlines
Nov 28
PTY11:48 amPanama City Tocumen Intl
6h 33m
SCL8:21 pmSantiago Arturo Merino Benitez
Nov 30
SCL1:08 amSantiago Arturo Merino Benitez
6h 52m
PTY6:00 amPanama City Tocumen Intl
$722
Find similar
Copa Airlines
Nov 14
PTY11:48 amPanama City Tocumen Intl
6h 33m
SCL8:21 pmSantiago Arturo Merino Benitez
Dec 1
SCL3:23 amSantiago Arturo Merino Benitez
6h 53m
PTY8:16 amPanama City Tocumen Intl
$740
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Tue 9/23

3:20 am-2:50 pm

2 stops33h 30m

Santiago Arturo Merino Benitez

Sat 9/27

12:55 am-10:10 am

1 stop11h 15m

$636

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 9/4

3:20 am-12:35 pm

2 stops32h 15m

Santiago Arturo Merino Benitez

Sat 9/20

12:55 am-10:10 am

1 stop11h 15m

$642

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Tue 9/16

5:25 pm-11:40 pm

2 stops28h 15m

Santiago Arturo Merino Benitez

Tue 9/23

7:10 am-4:30 pm

1 stop11h 20m

$653

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 10/31

2:55 pm-5:30 am

1 stop12h 35m

Santiago Arturo Merino Benitez

Sun 11/16

7:35 am-4:55 pm

1 stop11h 20m

$658

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 12/18

2:55 am-3:20 pm

1 stop10h 25m

Santiago Arturo Merino Benitez

Tue 1/6

7:25 am-4:55 pm

1 stop11h 30m

$669

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 12/21

2:55 am-3:20 pm

1 stop10h 25m

Santiago Arturo Merino Benitez

Sat 12/27

7:25 am-1:00 am

1 stop19h 35m

$673

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 11/1

7:11 pm-3:43 am

Nonstop6h 32m

Santiago Arturo Merino Benitez

Sun 11/9

3:23 am-8:16 am

Nonstop6h 53m

$706

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 11/28

11:48 am-8:21 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Sun 11/30

1:08 am-6:00 am

Nonstop6h 52m

$722

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 11/14

11:48 am-8:21 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Mon 12/1

3:23 am-8:16 am

Nonstop6h 53m

$740

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 9/22

3:32 pm-12:04 am

Nonstop6h 32m

Santiago Arturo Merino Benitez

Tue 9/30

1:24 am-6:16 am

Nonstop6h 52m

$749

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Panama City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Santiago?

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from Panama City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $524. If you don’t want to visit Santiago in October, then you should wait until June to fly from Panama City, when ticket prices are also cheap, with an average price of $545.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $587. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Wednesday is $674.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Panama City to Santiago when you can find flight prices for as low as $636. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $653 per ticket.

What is the cheapest Panama City Tocumen Intl to Santiago Arturo Merino Benitez flight route?

Fly from Panama City Tocumen Intl to Santiago Arturo Merino Benitez for the best Panama City Tocumen Intl - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $567 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Panama City for as low as $437 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Santiago Arturo Merino Benitez flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Santiago flights?

You could potentially save up to 75% on your flight if you consider stops on a Panama City to Santiago flight.

How have Panama City to Santiago flight prices changed over time?

As of August 2025, prices for Panama City to Santiago flights are approximately 6% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Santiago (PTY to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Santiago

Best Price Found

$1,004

Fastest flight time

6h 30m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Panama City in the past 72 hours is $1,004. The best round-trip flight deal from Panama City to Santiago found on momondo in the last 72 hours is $706.
The fastest flight from Panama City to Santiago takes 6h 30m
Direct flights go from Panama City to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
Search flight deals

  • How far is Panama City Tocumen Intl to Santiago Arturo Merino Benitez by plane?

    Santiago Arturo Merino Benitez is 2987.0 mi away from Panama City Tocumen Intl. In terms of flight time, this usually takes a little over 6h 32m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Santiago?

  • What is the most popular airline from Panama City to Santiago?

Best airlines flying from Panama City to Santiago

Compare and see reviews for airlines that fly from Panama City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $325Free CancellationRating
6.7
2,411 reviews
Search Avianca flights
Copa AirlinesPriceFrom $454Free CancellationRating
7.5
1,510 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to Santiago

    Across 35 Copa Airlines flights from Panama City to Santiago this week, the average price was $652, with the best Copa Airlines deals starting from $454 round-trip. 1,510 users have rated Copa Airlines on momondo, with an average score of 7.5/10.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama City to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama City to Santiago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Panama City to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from Panama City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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