Cheap flights from Panama City to Santiago from $309

In general, March is the cheapest month to fly from Panama City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $561. If you don’t want to visit Santiago in March, then you should wait until February to fly from Panama City, when ticket prices are also cheap, with an average price of $577.

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $590. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Friday is $679.

In the evening is the cheapest time of day to fly from Panama City to Santiago when you can find flight prices for as low as $625. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $665 per ticket.

Fly from Panama City Tocumen Intl to Santiago Arturo Merino Benitez for the best Panama City Tocumen Intl - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $612 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Panama City for as low as $576 on momondo.

There are 2 cabin classes available to choose from on Panama City to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 80% on your flight if you consider stops on a Panama City to Santiago flight.

As of October 2026, prices for Panama City to Santiago flights are approximately 70% more expensive when compared to flights at the same time last year.

Historically, on average around 10% of flights between Panama City and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 116 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 10% of their flights experiencing any sort of delay.

As of October 2026, 5 flights take off from Panama City and land in Santiago each day. The most common flight departure time for this route is 3:00PM, with 58% of daily flights taking off in the evening.

The number of flights available between Panama City and Santiago is 40 per week as of October 2026. The most frequent departure day is Wed, with 33% of weekly flights leaving on this day.