Cheap flights from Panama City to Cali from $162

The cheapest month to fly to Cali from Panama City is in March. Flight prices, which tend to average around $227, are often lower during this time because this is during the off-season. If you’re not able to fly to Cali in March, then November is your next best option. Flight prices from Panama City to Cali during November average around $239.

The cheapest day to depart on your flight to Cali is on a Saturday when prices can be found for as low as $268. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $412. These prices are subject to change though, so be sure to set up a Price Alert for flights to Cali.

Our most recent data shows that the best time of day to fly to Cali is in the morning. Flights from Panama City to Cali during this time can be as low as $315. In the evening is when there is more demand to fly to Cali, so prices are often more expensive at around $458 per ticket.

Fly from Panama City Tocumen Intl to Cali Alfonso B. Aragon Intl for the best Panama City Tocumen Intl - Cali Alfonso B. Aragon Intl flight prices

You are more likely to see cheaper flights to Cali from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Cali for around $268 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Cali from Panama City for as low as $215 on momondo.

There is only 1 cabin class available to choose from on Panama City to Cali flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 12% on your flight if you consider stops on a Panama City to Cali flight.

As of October 2026, prices for Panama City to Cali flights are approximately 0% more expensive when compared to flights at the same time last year.

Copa Airlines is the most popular carrier operating from Panama City Tocumen Intl to Cali Alfonso B. Aragon Intl

Copa Airlines, Wingo and Avianca are the top three most popular airlines that fly to Cali from Panama City according to our data. Copa Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Cali. Keep in mind that there are 3 different airlines that fly to Cali on a routine basis, so you have a few additional options to choose from.

Historically, on average around 5% of flights between Panama City and Cali have experienced a delay on any given week. The average delay length over the past 12 months has been 97 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Tuesday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 5% of their flights experiencing any sort of delay.

As of October 2026, there are 9 flights per day flying from Panama City to Cali. The most common time of day flights depart is 9:00PM, with 45% of flights taking off in the evening.

As of October 2026, there are 64 flights per week flying from Panama City to Cali. The most common day of the week flights depart is Mon, with 16% of flights taking off on this day.