Cheap flights from Panama City, Florida to South Carolina from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to South Carolina departing on 5/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:21 am - 12:19 pm
ECP
-
GSP
3h 58m
1 stop
American Airlines Logo
7:32 pm - 11:40 pm
GSP
-
ECP
5h 08m
1 stop
$259American Airlines
Wed, May 13 - Wed, May 27
United Airlines Logo
2:28 pm - 9:53 pm
ECP
-
GSP
6h 25m
1 stop
United Airlines Logo
6:30 am - 12:58 pm
GSP
-
ECP
7h 28m
1 stop
$297United Airlines
Tue, Sep 1 - Wed, Sep 2
Delta Logo
4:54 pm - 11:58 pm
ECP
-
MYR
6h 04m
1 stop
Delta Logo
6:00 am - 8:30 am
MYR
-
ECP
3h 30m
1 stop
$345Delta
Fri, May 15 - Mon, May 18
Delta Logo
6:41 pm - 11:55 pm
ECP
-
MYR
4h 14m
1 stop
Delta Logo
7:54 pm - 11:37 pm
MYR
-
ECP
4h 43m
1 stop
$347Delta
Fri, Jul 17 - Sun, Jul 19
Delta Logo
5:49 am - 10:20 am
ECP
-
GSP
3h 31m
1 stop
Delta Logo
10:09 am - 12:50 pm
GSP
-
ECP
3h 41m
1 stop
$351Delta
Tue, May 5 - Tue, May 12
Southwest Logo
7:15 am - 12:25 pm
ECP
-
CHS
4h 10m
1 stop
Southwest Logo
4:15 pm - 8:40 pm
CHS
-
ECP
5h 25m
1 stop
$355Southwest
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
6:20 pm - 10:45 pm
ECP
-
GSP
3h 25m
1 stop
Southwest Logo
6:50 am - 9:30 am
GSP
-
ECP
3h 40m
1 stop
$357Southwest
Mon, Jul 6 - Sun, Jul 12
Southwest Logo
7:55 am - 1:45 pm
ECP
-
MYR
4h 50m
1 stop
Southwest Logo
10:55 am - 7:50 pm
MYR
-
ECP
9h 55m
1 stop
$358Southwest
Sat, May 16 - Mon, May 18
American Airlines Logo
7:21 am - 12:19 pm
ECP
-
GSP
3h 58m
1 stop
American Airlines Logo
7:32 pm - 11:40 pm
GSP
-
ECP
5h 08m
1 stop
$359American Airlines
Wed, May 13 - Wed, May 27
Southwest Logo
7:15 am - 6:35 pm
ECP
-
CHS
10h 20m
2 stops
Southwest Logo
6:35 am - 9:30 am
CHS
-
ECP
3h 55m
1 stop
$360Southwest
Tue, Jun 2 - Tue, Jun 9

Southwest flights from Panama City, Florida to South Carolina

Our best Southwest deals on Panama City, Florida to South Carolina flight tickets
Southwest
Jun 2
ECP7:15 amPanama City NW Florida Beaches
4h 10m
1 stop
CHS12:25 pmCharleston
Jun 9
CHS4:15 pmCharleston
5h 25m
1 stop
ECP8:40 pmPanama City NW Florida Beaches
$355
Southwest
Jul 6
ECP6:20 pmPanama City NW Florida Beaches
3h 25m
1 stop
GSP10:45 pmGreenville
Jul 12
GSP6:50 amGreenville
3h 40m
1 stop
ECP9:30 amPanama City NW Florida Beaches
$357
Southwest
May 16
ECP7:55 amPanama City NW Florida Beaches
4h 50m
1 stop
MYR1:45 pmMyrtle Beach Intl
May 18
MYR10:55 amMyrtle Beach Intl
9h 55m
1 stop
ECP7:50 pmPanama City NW Florida Beaches
$358

Delta flights from Panama City, Florida to South Carolina

Our best Delta deals on Panama City, Florida to South Carolina flight tickets
Delta
May 15
ECP4:54 pmPanama City NW Florida Beaches
6h 04m
1 stop
MYR11:58 pmMyrtle Beach Intl
May 18
MYR6:00 amMyrtle Beach Intl
3h 30m
1 stop
ECP8:30 amPanama City NW Florida Beaches
$345
Delta
Jul 17
ECP6:41 pmPanama City NW Florida Beaches
4h 14m
1 stop
MYR11:55 pmMyrtle Beach Intl
Jul 19
MYR7:54 pmMyrtle Beach Intl
4h 43m
1 stop
ECP11:37 pmPanama City NW Florida Beaches
$347
Delta
May 5
ECP5:49 amPanama City NW Florida Beaches
3h 31m
1 stop
GSP10:20 amGreenville
May 12
GSP10:09 amGreenville
3h 41m
1 stop
ECP12:50 pmPanama City NW Florida Beaches
$351

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Panama City, Florida to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 5/13

7:21 am-12:19 pm

1 stop3h 58m

Greenville

Wed 5/27

7:32 pm-11:40 pm

1 stop5h 08m

$259

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 9/1

2:28 pm-9:53 pm

1 stop6h 25m

Greenville

Wed 9/2

6:30 am-12:58 pm

1 stop7h 28m

$297

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Fri 5/15

4:54 pm-11:58 pm

1 stop6h 04m

Myrtle Beach Intl

Mon 5/18

6:00 am-8:30 am

1 stop3h 30m

$345

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Fri 7/17

6:41 pm-11:55 pm

1 stop4h 14m

Myrtle Beach Intl

Sun 7/19

7:54 pm-11:37 pm

1 stop4h 43m

$347

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 5/5

5:49 am-10:20 am

1 stop3h 31m

Greenville

Tue 5/12

10:09 am-12:50 pm

1 stop3h 41m

$351

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 6/2

7:15 am-12:25 pm

1 stop4h 10m

Charleston

Tue 6/9

4:15 pm-8:40 pm

1 stop5h 25m

$355
Quickest round-trip

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 7/6

6:20 pm-10:45 pm

1 stop3h 25m

Greenville

Sun 7/12

6:50 am-9:30 am

1 stop3h 40m

$357

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Sat 5/16

7:55 am-1:45 pm

1 stop4h 50m

Myrtle Beach Intl

Mon 5/18

10:55 am-7:50 pm

1 stop9h 55m

$358

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 5/13

7:21 am-12:19 pm

1 stop3h 58m

Greenville

Wed 5/27

7:32 pm-11:40 pm

1 stop5h 08m

$359

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 6/2

7:15 am-6:35 pm

2 stops10h 20m

Charleston

Tue 6/9

6:35 am-9:30 am

1 stop3h 55m

$360

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Panama City, Florida to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to South Carolina?

Delta, American Airlines, and Southwest are the most popular carriers operating from Panama City NW Florida Beaches to South Carolina

Cheap Panama City, Florida to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to South Carolina

Fastest flight time

3h 39m

Direct flights

None
The fastest flight from Panama City, Florida to South Carolina takes 3h 39m
There are no direct flights from Panama City, Florida to South Carolina. There are no popular flight routes from Panama City, Florida to South Carolina.

Frequently asked questions about flying from Panama City, Florida to South Carolina

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to South Carolina?

    Prices for flights from Panama City NW Florida Beaches Airport to South Carolina are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to South Carolina?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City, Florida to South Carolina

Compare and see reviews for airlines that fly from Panama City, Florida to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $138Free CancellationRating
7.9
8,430 reviews
Search Delta flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,647 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

It is quick and easy to find Panama City to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

Flights from Panama City to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to South Carolina?

momondo helps you find the best flight between Panama City and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
Fri 5/22
Fri 5/29

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