Cheap flights from Panama City, Florida to South Carolina from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to South Carolina departing on 3/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:05 am - 1:31 pm
ECP
-
MYR
5h 26m
1 stop
Delta Logo
6:00 am - 8:40 am
MYR
-
ECP
3h 40m
1 stop
$291Delta
Tue, Mar 24 - Tue, Mar 31
Delta Logo
7:05 am - 1:31 pm
ECP
-
MYR
5h 26m
1 stop
Delta Logo
6:54 pm - 11:04 pm
MYR
-
ECP
5h 10m
1 stop
$329Delta
Tue, Mar 24 - Wed, Apr 1
Southwest Logo
7:55 am - 8:30 pm
ECP
-
MYR
11h 35m
2 stops
Southwest Logo
11:15 am - 8:45 pm
MYR
-
ECP
10h 30m
2 stops
$333Southwest
Wed, Apr 8 - Tue, Apr 14
Delta Logo
7:05 am - 1:31 pm
ECP
-
MYR
5h 26m
1 stop
Delta Logo
7:02 pm - 11:12 pm
MYR
-
ECP
5h 10m
1 stop
$339Delta
Wed, Apr 8 - Tue, Apr 14
American Airlines Logo
4:40 pm - 11:59 pm
ECP
-
CHS
6h 19m
1 stop
American Airlines Logo
5:00 am - 10:03 am
CHS
-
ECP
6h 03m
1 stop
$355American Airlines
Fri, Apr 24 - Sun, Apr 26
Delta Logo
5:30 pm - 12:04 am
ECP
-
MYR
5h 34m
1 stop
Delta Logo
6:00 am - 8:40 am
MYR
-
ECP
3h 40m
1 stop
$363Delta
Tue, Mar 24 - Sun, Mar 29
Southwest Logo
7:15 am - 12:25 pm
ECP
-
CHS
4h 10m
1 stop
Southwest Logo
1:15 pm - 7:50 pm
CHS
-
ECP
7h 35m
1 stop
$366Southwest
Tue, Apr 14 - Thu, Apr 16
American Airlines Logo
10:48 am - 4:06 pm
ECP
-
CHS
4h 18m
1 stop
American Airlines Logo
5:00 am - 10:03 am
CHS
-
ECP
6h 03m
1 stop
$456American Airlines
Thu, Apr 9 - Sun, Apr 12
United Airlines Logo
10:24 am - 11:59 pm
ECP
-
GSP
12h 35m
2 stops
United Airlines Logo
4:55 pm - 9:57 pm
GSP
-
ECP
6h 02m
1 stop
$457United Airlines
Wed, Mar 11 - Tue, Mar 24
United Airlines Logo
10:24 am - 11:59 pm
ECP
-
GSP
12h 35m
2 stops
United Airlines Logo
10:00 am - 1:14 pm
GSP
-
ECP
28h 14m
2 stops
$616United Airlines
Wed, Mar 11 - Tue, Mar 24

American Airlines flights from Panama City, Florida to South Carolina

Our best American Airlines deals on Panama City, Florida to South Carolina flight tickets
American Airlines
Apr 24
ECP4:40 pmPanama City NW Florida Beaches
6h 19m
1 stop
CHS11:59 pmCharleston
Apr 26
CHS5:00 amCharleston
6h 03m
1 stop
ECP10:03 amPanama City NW Florida Beaches
$355
American Airlines
Apr 9
ECP10:48 amPanama City NW Florida Beaches
4h 18m
1 stop
CHS4:06 pmCharleston
Apr 12
CHS5:00 amCharleston
6h 03m
1 stop
ECP10:03 amPanama City NW Florida Beaches
$456
American Airlines
Apr 16
ECP4:40 pmPanama City NW Florida Beaches
4h 36m
1 stop
CHS10:16 pmCharleston
Apr 19
CHS5:00 amCharleston
6h 03m
1 stop
ECP10:03 amPanama City NW Florida Beaches
$475

Southwest flights from Panama City, Florida to South Carolina

Our best Southwest deals on Panama City, Florida to South Carolina flight tickets
Southwest
Apr 8
ECP12:05 pmPanama City NW Florida Beaches
7h 25m
2 stops
MYR8:30 pmMyrtle Beach Intl
Apr 14
MYR11:15 amMyrtle Beach Intl
8h 40m
1 stop
ECP6:55 pmPanama City NW Florida Beaches
$333
Southwest
Apr 14
ECP7:15 amPanama City NW Florida Beaches
4h 10m
1 stop
CHS12:25 pmCharleston
Apr 16
CHS1:15 pmCharleston
9h 25m
2 stops
ECP9:40 pmPanama City NW Florida Beaches
$366
Southwest
Apr 14
ECP7:55 amPanama City NW Florida Beaches
11h 05m
2 stops
CHS8:00 pmCharleston
Apr 16
CHS1:15 pmCharleston
9h 25m
2 stops
ECP9:40 pmPanama City NW Florida Beaches
$371

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 2, 2026.
Use the filters below to find and compare flights from Panama City, Florida to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Tue 3/24

7:05 am-1:31 pm

1 stop5h 26m

Myrtle Beach Intl

Tue 3/31

6:00 am-8:40 am

1 stop3h 40m

$291

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Tue 3/24

7:05 am-1:31 pm

1 stop5h 26m

Myrtle Beach Intl

Wed 4/1

6:54 pm-11:04 pm

1 stop5h 10m

$329

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Wed 4/8

7:55 am-8:30 pm

2 stops11h 35m

Myrtle Beach Intl

Tue 4/14

11:15 am-8:45 pm

2 stops10h 30m

$333

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Wed 4/8

7:05 am-1:31 pm

1 stop5h 26m

Myrtle Beach Intl

Tue 4/14

7:02 pm-11:12 pm

1 stop5h 10m

$339

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Fri 4/24

4:40 pm-11:59 pm

1 stop6h 19m

Charleston

Sun 4/26

5:00 am-10:03 am

1 stop6h 03m

$355

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Tue 3/24

5:30 pm-12:04 am

1 stop5h 34m

Myrtle Beach Intl

Sun 3/29

6:00 am-8:40 am

1 stop3h 40m

$363

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 4/14

7:15 am-12:25 pm

1 stop4h 10m

Charleston

Thu 4/16

1:15 pm-7:50 pm

1 stop7h 35m

$366

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 4/9

10:48 am-4:06 pm

1 stop4h 18m

Charleston

Sun 4/12

5:00 am-10:03 am

1 stop6h 03m

$456

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 3/11

10:24 am-11:59 pm

2 stops12h 35m

Greenville

Tue 3/24

4:55 pm-9:57 pm

1 stop6h 02m

$457

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 3/11

10:24 am-11:59 pm

2 stops12h 35m

Greenville

Tue 3/24

10:00 am-1:14 pm

2 stops28h 14m

$616

Flights are sorted by cheapest round-trip flights first.

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See travel insights to South Carolina from

How to get the cheapest flight ticket from Panama City, Florida to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to South Carolina?

Southwest, Delta, and American Airlines are the most popular carriers operating from Panama City NW Florida Beaches to South Carolina

Cheap Panama City, Florida to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to South Carolina

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Panama City, Florida to South Carolina takes 3h 45m
There are no direct flights from Panama City, Florida to South Carolina. There are no popular flight routes from Panama City, Florida to South Carolina.
  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to South Carolina?

    Prices for flights from Panama City NW Florida Beaches Airport to South Carolina are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to South Carolina?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City, Florida to South Carolina

Compare and see reviews for airlines that fly from Panama City, Florida to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $138Free CancellationRating
7.9
8,237 reviews
Search Delta flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,369 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

It is quick and easy to find Panama City to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

Flights from Panama City to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to South Carolina?

momondo helps you find the best flight between Panama City and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
Wed 4/1
Wed 4/8

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