What airlines fly to South Carolina?

Delta, American Airlines and Spirit Airlines are the top three most popular airlines that fly to South Carolina from Panama City, Florida according to our data. Delta is the first choice among our users, with 70% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 3 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Panama City NW Florida Beaches to South Carolina?

Delta and American Airlines are the most popular carriers operating from Panama City NW Florida Beaches to South Carolina

When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to South Carolina?

Prices for flights from Panama City NW Florida Beaches Airport to South Carolina are updated daily.

How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to South Carolina?

There are 2 operators available for flights from Panama City NW Florida Beaches Airport to South Carolina as of August 2025.

How old do you have to be to fly from Panama City NW Florida Beaches Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$102 Cheap Flights from Panama City to South Carolina in 2025

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Find the cheapest flights from Panama City, Florida to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

6:00 am - 10:21 amECP-CHS

3h 21m1 stop

5:35 am - 10:19 amCHS-ECP

5h 44m1 stop

$197Delta

Find Deal

Thu, Oct 30 - Mon, Nov 3

6:17 pm - 11:54 pmECP-GSP

4h 37m1 stop

11:04 am - 3:20 pmGSP-ECP

5h 16m1 stop

$203Delta

Find Deal

Mon, Oct 27 - Thu, Oct 30

6:59 pm - 12:05 amECP-CHS

4h 06m1 stop

5:00 am - 9:42 amCHS-ECP

5h 42m1 stop

$222American Airlines

Find Deal

Thu, Sep 11 - Sun, Sep 14

6:00 am - 10:10 amECP-MYR

3h 10m1 stop

6:58 pm - 11:10 pmMYR-ECP

5h 12m1 stop

$222Delta

Find Deal

Fri, Oct 3 - Mon, Oct 6

9:13 am - 1:28 pmECP-GSP

3h 15m1 stop

11:04 am - 3:20 pmGSP-ECP

5h 16m1 stop

$229Delta

Find Deal

Fri, Oct 3 - Mon, Oct 6

11:58 am - 11:59 pmECP-CHS

11h 01m2 stops

5:39 pm - 11:15 pmCHS-ECP

6h 36m1 stop

$262American Airlines

Find Deal

Thu, Oct 30 - Mon, Nov 3

1:35 pm - 10:00 pmECP-CHS

7h 25m2 stops

5:30 am - 9:55 amCHS-ECP

5h 25m1 stop

$272Southwest

Find Deal

Thu, Sep 4 - Mon, Sep 8

1:35 pm - 10:00 pmECP-CHS

7h 25m2 stops

11:00 am - 4:55 pmCHS-ECP

6h 55m2 stops

$277Southwest

Find Deal

Thu, Sep 4 - Mon, Sep 8

11:09 am - 2:06 pmECP-MYR

25h 57m2 stops

6:11 pm - 1:03 pmMYR-ECP

19h 52m2 stops

$625United Airlines

Find Deal

Thu, Aug 21 - Mon, Aug 25

2:27 pm - 2:58 pmECP-GSP

23h 31m2 stops

12:34 pm - 1:03 pmGSP-ECP

25h 29m1 stop

$634United Airlines

Find Deal

Wed, Aug 20 - Sun, Aug 24

Southwest flights from Panama City, Florida to South Carolina

Our best Southwest deals on Panama City, Florida to South Carolina flight tickets

Southwest

Sep 4

ECP1:35 pmPanama City NW Florida Beaches

7h 25m

2 stops

CHS10:00 pmCharleston

Sep 8

CHS5:30 amCharleston

5h 25m

1 stop

ECP9:55 amPanama City NW Florida Beaches

$272

Find similar

Southwest

Sep 4

ECP1:35 pmPanama City NW Florida Beaches

7h 25m

2 stops

CHS10:00 pmCharleston

Sep 8

CHS11:00 amCharleston

6h 55m

2 stops

ECP4:55 pmPanama City NW Florida Beaches

$277

Find similar

Southwest

Oct 3

ECP2:55 pmPanama City NW Florida Beaches

3h 30m

1 stop

GSP7:25 pmGreenville

Oct 6

GSP1:50 pmGreenville

9h 45m

2 stops

ECP10:35 pmPanama City NW Florida Beaches

$324

Find similar

American Airlines flights from Panama City, Florida to South Carolina

Our best American Airlines deals on Panama City, Florida to South Carolina flight tickets

American Airlines

Sep 11

ECP6:59 pmPanama City NW Florida Beaches

4h 06m

1 stop

CHS12:05 amCharleston

Sep 14

CHS5:00 amCharleston

5h 42m

1 stop

ECP9:42 amPanama City NW Florida Beaches

$222

Find similar

American Airlines

Oct 30

ECP11:58 amPanama City NW Florida Beaches

11h 01m

2 stops

CHS11:59 pmCharleston

Nov 3

CHS5:39 pmCharleston

6h 36m

1 stop

ECP11:15 pmPanama City NW Florida Beaches

$262

Find similar

American Airlines

Oct 30

ECP11:58 amPanama City NW Florida Beaches

11h 01m

2 stops

CHS11:59 pmCharleston

Nov 3

CHS7:12 pmCharleston

5h 03m

1 stop

ECP11:15 pmPanama City NW Florida Beaches

$291

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Panama City, Florida to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 10/30

6:00 am-10:21 am

1 stop3h 21m

Charleston

Mon 11/3

5:35 am-10:19 am

1 stop5h 44m

$197

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 10/27

6:17 pm-11:54 pm

1 stop4h 37m

Greenville

Thu 10/30

11:04 am-3:20 pm

1 stop5h 16m

$203

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 9/11

6:59 pm-12:05 am

1 stop4h 06m

Charleston

Sun 9/14

5:00 am-9:42 am

1 stop5h 42m

$222

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Fri 10/3

6:00 am-10:10 am

1 stop3h 10m

Myrtle Beach Intl

Mon 10/6

6:58 pm-11:10 pm

1 stop5h 12m

$222

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 10/3

9:13 am-1:28 pm

1 stop3h 15m

Greenville

Mon 10/6

11:04 am-3:20 pm

1 stop5h 16m

$229

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 10/30

11:58 am-11:59 pm

2 stops11h 01m

Charleston

Mon 11/3

5:39 pm-11:15 pm

1 stop6h 36m

$262

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 9/4

1:35 pm-10:00 pm

2 stops7h 25m

Charleston

Mon 9/8

5:30 am-9:55 am

1 stop5h 25m

$272

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 9/4

1:35 pm-10:00 pm

2 stops7h 25m

Charleston

Mon 9/8

11:00 am-4:55 pm

2 stops6h 55m

$277

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Thu 8/21

11:09 am-2:06 pm

2 stops25h 57m

Myrtle Beach Intl

Mon 8/25

6:11 pm-1:03 pm

2 stops19h 52m

$625

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 8/20

2:27 pm-2:58 pm

2 stops23h 31m

Greenville

Sun 8/24

12:34 pm-1:03 pm

1 stop25h 29m

$634

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama City, Florida to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Panama City, Florida is in December. Flight prices, which tend to average around $257, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to South Carolina from Panama City, Florida during October instead. Flights to South Carolina in October, while not as cheap as those in December, still average around $276.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $286. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $523.

Cheap Panama City, Florida to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to South Carolina

Best Price Found	$102
Fastest flight time	3h 07m
Direct flights	None
Airports in South Carolina	3 airports

The best one-way flight to South Carolina from Panama City, Florida in the past 72 hours is $102. The best round-trip flight deal from Panama City, Florida to South Carolina found on momondo in the last 72 hours is $197.

The fastest flight from Panama City, Florida to South Carolina takes 3h 07m

There are no direct flights from Panama City, Florida to South Carolina. Popular non-direct routes for this connection are Panama City NW Florida Beaches Airport - Greenville Airport, Panama City NW Florida Beaches Airport - Charleston Airport and Panama City NW Florida Beaches Airport - Myrtle Beach Intl Airport.

There are 3 airports near South Carolina: Greenville (GSP), Myrtle Beach Intl (MYR), Charleston (CHS)

Search flight deals

When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to South Carolina?
Prices for flights from Panama City NW Florida Beaches Airport to South Carolina are updated daily.
How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to South Carolina?
There are 2 operators available for flights from Panama City NW Florida Beaches Airport to South Carolina as of August 2025.
How old do you have to be to fly from Panama City NW Florida Beaches Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City, Florida to South Carolina

Compare and see reviews for airlines that fly from Panama City, Florida to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $216	Free Cancellation	Rating 8.0 7,985 reviews		Search Delta flights
American Airlines	PriceFrom $225	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

It is quick and easy to find Panama City to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

Flights from Panama City to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to South Carolina?

momondo helps you find the best flight between Panama City and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Popular cities in South Carolina

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Cheap flights from Panama City, Florida to South Carolina from $102

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Panama City, Florida to South Carolina

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Southwest flights from Panama City, Florida to South Carolina

Our best Southwest deals on Panama City, Florida to South Carolina flight tickets

American Airlines flights from Panama City, Florida to South Carolina

Our best American Airlines deals on Panama City, Florida to South Carolina flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Panama City, Florida to South Carolina that are best for you.

See travel insights to South Carolina from

How to get the cheapest flight ticket from Panama City, Florida to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $286. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $523.

What is the cheapest airline that flies from Panama City NW Florida Beaches to South Carolina?

Delta and American Airlines are the most popular carriers operating from Panama City NW Florida Beaches to South Carolina

What airlines fly to South Carolina?

Cheap Panama City, Florida to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to South Carolina?

How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to South Carolina?

How old do you have to be to fly from Panama City NW Florida Beaches Airport to South Carolina?

What documentation or ID do you need to fly to South Carolina?

Best airlines flying from Panama City, Florida to South Carolina

Compare and see reviews for airlines that fly from Panama City, Florida to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Panama City to South Carolina?

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo