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Cheap flights from Chicago O'Hare Intl Airport to South America from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to South America departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Chicago O'Hare Intl Airport to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
3:20 pm - 8:40 amORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
17h 20m1 stop Panama City Tocumen Intl
Copa Airlines Logo
6:20 am - 1:02 amCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
18h 42m1 stop Panama City Tocumen Intl
$365Copa Airlines
Sat, Sep 19 - Sun, Sep 27
Copa Airlines Logo
3:20 pm - 8:05 amORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
16h 45m1 stop Panama City Tocumen Intl
Copa Airlines Logo
12:00 pm - 12:57 amCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
12h 57m1 stop Panama City Tocumen Intl
$365Copa Airlines
Sat, Oct 10 - Wed, Oct 14
American Airlines Logo
5:00 am - 1:35 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
7h 35m1 stop Miami
American Airlines Logo
2:35 pm - 12:44 amCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
11h 09m1 stop Miami
$377American Airlines
Tue, Nov 10 - Sat, Nov 14
American Airlines Logo
7:00 pm - 12:35 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
17h 35m1 stop Miami
American Airlines Logo
1:35 pm - 12:38 amCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
11h 03m1 stop Miami
$377American Airlines
Mon, Sep 21 - Sat, Oct 10
United Airlines Logo
6:00 am - 2:50 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
7h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
2:20 pm - 12:15 amCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
10h 55m1 stop Houston George Bush Intcntl
$377United Airlines
Sun, Jan 17 - Sat, Jan 23
United Airlines Logo
6:00 am - 2:50 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
7h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
2:20 pm - 12:15 amCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
10h 55m1 stop Houston George Bush Intcntl
$377United Airlines
Thu, Jan 28 - Thu, Feb 4
LATAM Airlines Logo
5:27 am - 1:15 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
7h 48m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
3:30 pm - 11:52 pmCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
9h 22m1 stop Atlanta Hartsfield-Jackson
$377LATAM Airlines
Sat, Oct 31 - Sat, Nov 7
LATAM Airlines Logo
5:30 am - 1:15 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
7h 45m1 stop Atlanta Hartsfield-Jackson
LATAM Airlines Logo
2:30 pm - 11:57 pmCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
9h 27m1 stop Atlanta Hartsfield-Jackson
$377LATAM Airlines
Tue, Sep 1 - Sat, Sep 5
Delta Logo
5:27 am - 1:15 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
7h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:30 pm - 11:52 pmCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
9h 22m1 stop Atlanta Hartsfield-Jackson
$377Delta
Sat, Oct 24 - Sat, Oct 31
Delta Logo
5:10 pm - 1:05 pmORD  Chicago O'Hare Intl-CTG Cartagena Rafael Nunez
19h 55m2 stops Detroit Metropolitan Wayne County Atlanta Hartsfield-Jackson
Delta Logo
2:30 pm - 11:59 pmCTG  Cartagena Rafael Nunez-ORD Chicago O'Hare Intl
9h 29m1 stop Atlanta Hartsfield-Jackson
$382Delta
Fri, Sep 11 - Sat, Sep 19

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United Airlines flights from Chicago O'Hare Intl Airport to South America

Our best United Airlines deals on Chicago O'Hare Intl Airport to South America flight tickets
United Airlines
Jan 17
ORD6:00 amChicago O'Hare Intl
7h 50m
1 stop
CTG2:50 pmCartagena Rafael Nunez
Jan 23
CTG4:00 pmCartagena Rafael Nunez
16h 23m
1 stop
ORD7:23 amChicago O'Hare Intl
$377
United Airlines
Sep 12
ORD4:11 pmChicago O'Hare Intl
12h 43m
1 stop
BOG4:54 amBogotá El Dorado
Sep 25
BOG8:30 amBogotá El Dorado
14h 56m
1 stop
ORD11:26 pmChicago O'Hare Intl
$414
United Airlines
Sep 5
ORD9:35 pmChicago O'Hare Intl
24h 25m
1 stop
BOG10:00 pmBogotá El Dorado
Sep 20
BOG8:30 amBogotá El Dorado
16h 29m
1 stop
ORD12:59 amChicago O'Hare Intl
$416

Avianca flights from Chicago O'Hare Intl Airport to South America

Our best Avianca deals on Chicago O'Hare Intl Airport to South America flight tickets
Avianca
Oct 29
ORD11:20 pmChicago O'Hare Intl
15h 15m
1 stop
CTG2:35 pmCartagena Rafael Nunez
Nov 2
CTG7:15 amCartagena Rafael Nunez
14h 05m
1 stop
ORD8:20 pmChicago O'Hare Intl
$402
Avianca
Jan 14
ORD10:20 pmChicago O'Hare Intl
31h 15m
1 stop
CTG6:35 amCartagena Rafael Nunez
Jan 19
CTG10:05 pmCartagena Rafael Nunez
23h 15m
1 stop
ORD8:20 pmChicago O'Hare Intl
$405
Avianca
Nov 11
ORD10:20 pmChicago O'Hare Intl
13h 10m
1 stop
CTG12:30 pmCartagena Rafael Nunez
Nov 14
CTG8:30 amCartagena Rafael Nunez
12h 50m
1 stop
ORD8:20 pmChicago O'Hare Intl
$422

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Sat 9/19

3:20 pm-8:40 am

1 stop17h 20m

Cartagena Rafael Nunez

Sun 9/27

6:20 am-1:02 am

1 stop18h 42m

$365

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Sat 10/10

3:20 pm-8:05 am

1 stop16h 45m

Cartagena Rafael Nunez

Wed 10/14

12:00 pm-12:57 am

1 stop12h 57m

$365

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Tue 11/10

5:00 am-1:35 pm

1 stop7h 35m

Cartagena Rafael Nunez

Sat 11/14

2:35 pm-12:44 am

1 stop11h 09m

$377

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Mon 9/21

7:00 pm-12:35 pm

1 stop17h 35m

Cartagena Rafael Nunez

Sat 10/10

1:35 pm-12:38 am

1 stop11h 03m

$377

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Sun 1/17

6:00 am-2:50 pm

1 stop7h 50m

Cartagena Rafael Nunez

Sat 1/23

2:20 pm-12:15 am

1 stop10h 55m

$377

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Thu 1/28

6:00 am-2:50 pm

1 stop7h 50m

Cartagena Rafael Nunez

Thu 2/4

2:20 pm-12:15 am

1 stop10h 55m

$377
Quickest round-trip

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Sat 10/31

5:27 am-1:15 pm

1 stop7h 48m

Cartagena Rafael Nunez

Sat 11/7

3:30 pm-11:52 pm

1 stop9h 22m

$377

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Tue 9/1

5:30 am-1:15 pm

1 stop7h 45m

Cartagena Rafael Nunez

Sat 9/5

2:30 pm-11:57 pm

1 stop9h 27m

$377

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Sat 10/24

5:27 am-1:15 pm

1 stop7h 48m

Cartagena Rafael Nunez

Sat 10/31

2:30 pm-11:52 pm

1 stop9h 22m

$377

ChicagoCartagena

ORD Chicago O'Hare Intl - CTG Cartagena Rafael Nunez

ORDCTG

Chicago O'Hare Intl

Fri 9/11

5:10 pm-1:05 pm

2 stops19h 55m

Cartagena Rafael Nunez

Sat 9/19

2:30 pm-11:59 pm

1 stop9h 29m

$382

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Chicago O'Hare Intl Airport to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $528. If you aren’t able to travel during the month of February, then book flights to South America from Chicago O'Hare Intl Airport during October instead. Flights to South America in October, while not as cheap as those in February, still average around $540.

What is the cheapest Chicago O'Hare Intl to South America flight route?

Fly from Chicago O'Hare Intl to Bogotá El Dorado for the best Chicago O'Hare Intl - South America flight prices

How far in advance should I book a flight from Chicago O'Hare Intl Airport to South America?

You are more likely to see cheaper flights to South America from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $654 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Chicago O'Hare Intl Airport for as low as $582 on momondo.

What cabin class options are available on Chicago O'Hare Intl Airport to South America flights?

There are 3 cabin classes available to choose from on Chicago O'Hare Intl Airport to South America flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to South America flights?

You could potentially save up to 19% on your flight if you consider stops on a Chicago O'Hare Intl Airport to South America flight.

Cheap Chicago O'Hare Intl Airport to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South America

Best Price Found

$410

Fastest flight time

6h 10m

Direct flights

Every day

Airports in South America

464 airports
The best one-way flight to South America from Chicago O'Hare Intl Airport in the past 72 hours is $410. The best round-trip flight deal from Chicago O'Hare Intl Airport to South America found on momondo in the last 72 hours is $511.
The fastest flight from Chicago O'Hare Intl Airport to South America takes 6h 10m
Direct flights go from Chicago O'Hare Intl Airport to South America every day.
There are 464 airports in South America. From Chicago O'Hare Intl Airport there are direct flights to Bogotá El Dorado (BOG).
Search flight deals

Frequently asked questions about flying from Chicago O'Hare Intl Airport to South America

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South America?

    Prices for flights from Chicago O'Hare Intl Airport to South America refresh daily.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South America?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago O'Hare Intl Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to South America?

Best airlines flying from Chicago O'Hare Intl Airport to South America

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $153Free CancellationRating
7.8
8,505 reviews
Search Delta flights
JetBluePriceFrom $161Free CancellationRating
7.1
3,034 reviews
Search JetBlue flights
United AirlinesPriceFrom $204Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $212Free CancellationRating
7.4
1,977 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $258Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
GOLPriceFrom $269Free CancellationRating
7.3
1,273 reviews
Search GOL flights
ArajetPriceFrom $272Free CancellationRating
6.2
53 reviews
Search Arajet flights
AviancaPriceFrom $298Free CancellationRating
6.5
2,532 reviews
Search Avianca flights
American AirlinesPriceFrom $317Free CancellationRating
7.1
11,908 reviews
Search American Airlines flights
Air CanadaPriceFrom $479Free CancellationRating
7.1
11,462 reviews
Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South America?

It is quick and easy to find Chicago to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from Chicago to South America with flexible booking policies on momondo?

Yes. All flights to South America from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to South America?

momondo provides multiple filters to help you find the best flight to South America from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South America trip

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Find better results for your trip to South America

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