Cheap flights from North Carolina to South America from $115

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to South America departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:07 pm - 12:26 pm
CLT
-
CTG
16h 19m
1 stop
Spirit Airlines Logo
1:31 pm - 11:40 pm
CTG
-
CLT
9h 09m
1 stop
$224Spirit Airlines
Sun, May 17 - Wed, May 20
Spirit Airlines Logo
6:00 am - 12:26 pm
CLT
-
CTG
7h 26m
1 stop
Spirit Airlines Logo
1:31 pm - 11:40 pm
CTG
-
CLT
9h 09m
1 stop
$234Spirit Airlines
Mon, May 18 - Wed, May 27
Multiple Airlines Logo
5:50 pm - 12:26 pm
CLT
-
CTG
19h 36m
1 stop
Multiple Airlines Logo
1:31 pm - 11:40 pm
CTG
-
CLT
9h 09m
1 stop
$270Multiple Airlines
Sat, May 9 - Wed, May 13
Copa Airlines Logo
4:19 pm - 8:15 am
RDU
-
MDE
16h 56m
1 stop
Copa Airlines Logo
5:00 am - 2:29 pm
MDE
-
RDU
8h 29m
1 stop
$289Copa Airlines
Wed, May 6 - Mon, May 11
American Airlines Logo
6:25 pm - 12:35 pm
RDU
-
CTG
19h 10m
2 stops
American Airlines Logo
1:35 pm - 9:51 am
CTG
-
RDU
19h 16m
2 stops
$294American Airlines
Fri, Jun 5 - Wed, Jun 10
Copa Airlines Logo
4:19 pm - 8:40 am
RDU
-
CTG
17h 21m
1 stop
Copa Airlines Logo
6:20 am - 2:29 pm
CTG
-
RDU
7h 09m
1 stop
$298Copa Airlines
Sun, May 10 - Wed, May 13
American Airlines Logo
7:55 pm - 2:04 pm
RDU
-
CTG
19h 09m
1 stop
American Airlines Logo
1:35 pm - 9:55 am
CTG
-
RDU
19h 20m
2 stops
$301American Airlines
Sat, May 16 - Thu, May 21
Delta Logo
5:18 am - 1:20 pm
RDU
-
CTG
9h 02m
1 stop
Delta Logo
2:13 pm - 8:51 am
CTG
-
RDU
17h 38m
1 stop
$309Delta
Sat, May 2 - Thu, May 21
Delta Logo
6:35 am - 1:13 pm
RDU
-
CTG
7h 38m
1 stop
Delta Logo
2:30 pm - 12:27 am
CTG
-
RDU
8h 57m
1 stop
$311Delta
Tue, Sep 1 - Thu, Sep 10
Multiple Airlines Logo
7:30 am - 10:50 pm
CLT
-
MDE
16h 20m
2 stops
Multiple Airlines Logo
1:55 pm - 6:52 pm
MDE
-
CLT
27h 57m
1 stop
$374Multiple Airlines
Wed, May 13 - Mon, May 18

GOL flights from North Carolina to South America

Our best GOL deals on North Carolina to South America flight tickets
GOL
May 4
RDU5:05 amRaleigh-Durham
9h 59m
2 stops
CTG2:04 pmCartagena Rafael Nunez
May 18
CTG1:25 pmCartagena Rafael Nunez
22h 32m
2 stops
RDU12:57 pmRaleigh-Durham
$483
GOL
Jun 12
RDU8:08 pmRaleigh-Durham
16h 12m
2 stops
BOG11:20 amBogotá El Dorado
Jun 30
BOG12:21 pmBogotá El Dorado
18h 46m
2 stops
RDU8:07 amRaleigh-Durham
$484
GOL
May 5
RDU12:17 pmRaleigh-Durham
10h 00m
2 stops
BOG9:17 pmBogotá El Dorado
May 9
BOG2:10 pmBogotá El Dorado
16h 56m
2 stops
RDU8:06 amRaleigh-Durham
$540

LATAM Airlines flights from North Carolina to South America

Our best LATAM Airlines deals on North Carolina to South America flight tickets
LATAM Airlines
May 18
RDU7:55 pmRaleigh-Durham
18h 03m
1 stop
CTG12:58 pmCartagena Rafael Nunez
May 23
CTG2:30 pmCartagena Rafael Nunez
17h 21m
1 stop
RDU8:51 amRaleigh-Durham
$315
LATAM Airlines
Jul 19
RDU8:15 amRaleigh-Durham
12h 55m
1 stop
BOG8:10 pmBogotá El Dorado
Aug 4
BOG8:40 amBogotá El Dorado
11h 13m
1 stop
RDU8:53 pmRaleigh-Durham
$345
LATAM Airlines
Sep 8
RDU12:40 pmRaleigh-Durham
7h 35m
1 stop
BOG7:15 pmBogotá El Dorado
Oct 6
BOG11:00 amBogotá El Dorado
8h 56m
1 stop
RDU8:56 pmRaleigh-Durham
$355

momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from North Carolina to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sun 5/17

9:07 pm-12:26 pm

1 stop16h 19m

Cartagena Rafael Nunez

Wed 5/20

1:31 pm-11:40 pm

1 stop9h 09m

$224
Quickest round-trip

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Mon 5/18

6:00 am-12:26 pm

1 stop7h 26m

Cartagena Rafael Nunez

Wed 5/27

1:31 pm-11:40 pm

1 stop9h 09m

$234

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sat 5/9

5:50 pm-12:26 pm

1 stop19h 36m

Cartagena Rafael Nunez

Wed 5/13

1:31 pm-11:40 pm

1 stop9h 09m

$270

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Wed 5/6

4:19 pm-8:15 am

1 stop16h 56m

Medellín Jose Maria Cordova Intl

Mon 5/11

5:00 am-2:29 pm

1 stop8h 29m

$289

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Fri 6/5

6:25 pm-12:35 pm

2 stops19h 10m

Cartagena Rafael Nunez

Wed 6/10

1:35 pm-9:51 am

2 stops19h 16m

$294

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Sun 5/10

4:19 pm-8:40 am

1 stop17h 21m

Cartagena Rafael Nunez

Wed 5/13

6:20 am-2:29 pm

1 stop7h 09m

$298

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Sat 5/16

7:55 pm-2:04 pm

1 stop19h 09m

Cartagena Rafael Nunez

Thu 5/21

1:35 pm-9:55 am

2 stops19h 20m

$301

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Sat 5/2

5:18 am-1:20 pm

1 stop9h 02m

Cartagena Rafael Nunez

Thu 5/21

2:13 pm-8:51 am

1 stop17h 38m

$309

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Tue 9/1

6:35 am-1:13 pm

1 stop7h 38m

Cartagena Rafael Nunez

Thu 9/10

2:30 pm-12:27 am

1 stop8h 57m

$311

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 5/13

7:30 am-10:50 pm

2 stops16h 20m

Medellín Jose Maria Cordova Intl

Mon 5/18

1:55 pm-6:52 pm

1 stop27h 57m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from North Carolina to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from North Carolina to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $487. If you aren’t able to travel during the month of September, then book flights to South America from North Carolina during November instead. Flights to South America in November, while not as cheap as those in September, still average around $497.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $574 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from North Carolina for as low as $495 on momondo.

Can stopping save me money on North Carolina to South America flights?

You could potentially save up to 1% on your flight if you consider stops on a North Carolina to South America flight.

Cheap North Carolina to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to South America

Fastest flight time

5h 49m

Direct flights

None
The fastest flight from North Carolina to South America takes 5h 49m
There are no direct flights from North Carolina to South America. There are no popular flight routes from North Carolina to South America.

Frequently asked questions about flying from North Carolina to South America

  • When did momondo last update prices for flights from North Carolina to South America?

    Prices for flights from North Carolina to South America are refreshed on a daily basis.

  • How many operators does momondo search for flights from North Carolina to South America?

  • How old do you have to be to fly from North Carolina to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from North Carolina to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from North Carolina to South America

Compare and see reviews for airlines that fly from North Carolina to South America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $102Free CancellationRating
7.9
8,433 reviews
Search Delta flights
LATAM AirlinesPriceFrom $143Free CancellationRating
7.4
1,910 reviews
Search LATAM Airlines flights
Spirit AirlinesPriceFrom $149Free CancellationRating
6.3
8,630 reviews
Search Spirit Airlines flights
JetBluePriceFrom $197Free CancellationRating
7.2
2,948 reviews
Search JetBlue flights
Copa AirlinesPriceFrom $216Free CancellationRating
7.5
1,580 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $264Free CancellationRating
7.4
9,613 reviews
Search United Airlines flights
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,646 reviews
Search American Airlines flights
GOLPriceFrom $447Free CancellationRating
7.3
1,204 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to South America?

It is quick and easy to find North Carolina to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from North Carolina to South America with flexible booking policies on momondo?

Flights from North Carolina to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from North Carolina to South America?

Once you have performed a search for North Carolina to South America flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from North Carolina to South America right now. Can momondo alert me if prices change?

Yes. momondo can track prices for North Carolina to South America flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your South America trip

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1 adult
Thu 5/21
Thu 5/28

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