Cheap flights from North Carolina to South America from $93

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to South America departing on 4/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:54 pm - 12:06 pm
CLT
-
CTG
15h 12m
1 stop
Spirit Airlines Logo
1:11 pm - 8:49 pm
CTG
-
CLT
6h 38m
1 stop
$236Spirit Airlines
Sun, Apr 26 - Thu, Apr 30
Spirit Airlines Logo
6:00 am - 12:06 pm
CLT
-
CTG
7h 06m
1 stop
Spirit Airlines Logo
1:11 pm - 8:49 pm
CTG
-
CLT
6h 38m
1 stop
$242Spirit Airlines
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
7:55 pm - 12:09 pm
RDU
-
CTG
17h 14m
1 stop
American Airlines Logo
1:25 pm - 10:32 am
CTG
-
RDU
20h 07m
2 stops
$273American Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
8:13 pm - 12:09 pm
RDU
-
CTG
16h 56m
2 stops
American Airlines Logo
1:25 pm - 8:06 am
CTG
-
RDU
17h 41m
2 stops
$276American Airlines
Fri, Apr 17 - Fri, Apr 24
Copa Airlines Logo
4:19 pm - 8:40 am
RDU
-
CTG
17h 21m
1 stop
Copa Airlines Logo
6:20 am - 2:29 pm
CTG
-
RDU
7h 09m
1 stop
$279Copa Airlines
Fri, May 8 - Mon, May 11
Copa Airlines Logo
4:18 pm - 8:15 am
RDU
-
MDE
16h 57m
1 stop
Copa Airlines Logo
5:00 am - 2:29 pm
MDE
-
RDU
8h 29m
1 stop
$303Copa Airlines
Sun, Apr 12 - Sun, Apr 19
United Airlines Logo
6:00 am - 9:10 pm
RDU
-
MDE
16h 10m
2 stops
United Airlines Logo
9:45 am - 9:58 pm
MDE
-
RDU
11h 13m
1 stop
$320United Airlines
Fri, May 8 - Wed, May 13
United Airlines Logo
6:15 am - 9:10 pm
RDU
-
MDE
15h 55m
1 stop
United Airlines Logo
9:45 am - 9:58 pm
MDE
-
RDU
11h 13m
1 stop
$330United Airlines
Tue, May 5 - Tue, May 12
Multiple Airlines Logo
6:00 am - 2:40 pm
RDU
-
GYE
9h 40m
1 stop
Multiple Airlines Logo
4:00 pm - 10:07 am
GYE
-
RDU
17h 07m
1 stop
$347Multiple Airlines
Tue, Apr 7 - Tue, Apr 28
Multiple Airlines Logo
7:46 pm - 11:04 pm
RDU
-
GYE
28h 18m
1 stop
Multiple Airlines Logo
3:45 pm - 8:18 am
GYE
-
RDU
15h 33m
2 stops
$360Multiple Airlines
Wed, Apr 1 - Wed, Apr 15

Spirit Airlines flights from North Carolina to South America

Our best Spirit Airlines deals on North Carolina to South America flight tickets
Spirit Airlines
Apr 26
CLT9:54 pmCharlotte Douglas
15h 12m
1 stop
CTG12:06 pmCartagena Rafael Nunez
Apr 30
CTG1:11 pmCartagena Rafael Nunez
6h 38m
1 stop
CLT8:49 pmCharlotte Douglas
$236
Spirit Airlines
Apr 11
CLT6:00 amCharlotte Douglas
7h 06m
1 stop
CTG12:06 pmCartagena Rafael Nunez
Apr 15
CTG1:11 pmCartagena Rafael Nunez
6h 38m
1 stop
CLT8:49 pmCharlotte Douglas
$242
Spirit Airlines
Apr 26
CLT9:54 pmCharlotte Douglas
15h 12m
1 stop
CTG12:06 pmCartagena Rafael Nunez
Apr 30
CTG1:11 pmCartagena Rafael Nunez
6h 38m
1 stop
CLT8:49 pmCharlotte Douglas
$262

Copa Airlines flights from North Carolina to South America

Our best Copa Airlines deals on North Carolina to South America flight tickets
Copa Airlines
May 8
RDU4:19 pmRaleigh-Durham
17h 21m
1 stop
CTG8:40 amCartagena Rafael Nunez
May 11
CTG6:20 amCartagena Rafael Nunez
7h 09m
1 stop
RDU2:29 pmRaleigh-Durham
$279
Copa Airlines
Apr 12
RDU4:18 pmRaleigh-Durham
16h 57m
1 stop
MDE8:15 amMedellín Jose Maria Cordova Intl
Apr 19
MDE5:00 amMedellín Jose Maria Cordova Intl
8h 29m
1 stop
RDU2:29 pmRaleigh-Durham
$303
Copa Airlines
Apr 17
RDU4:18 pmRaleigh-Durham
17h 22m
1 stop
CTG8:40 amCartagena Rafael Nunez
Apr 24
CTG6:20 amCartagena Rafael Nunez
7h 09m
1 stop
RDU2:29 pmRaleigh-Durham
$313

momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from North Carolina to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sun 4/26

9:54 pm-12:06 pm

1 stop15h 12m

Cartagena Rafael Nunez

Thu 4/30

1:11 pm-8:49 pm

1 stop6h 38m

$236
Quickest round-trip

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sat 4/11

6:00 am-12:06 pm

1 stop7h 06m

Cartagena Rafael Nunez

Wed 4/15

1:11 pm-8:49 pm

1 stop6h 38m

$242

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Sat 4/18

7:55 pm-12:09 pm

1 stop17h 14m

Cartagena Rafael Nunez

Sat 4/25

1:25 pm-10:32 am

2 stops20h 07m

$273

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Fri 4/17

8:13 pm-12:09 pm

2 stops16h 56m

Cartagena Rafael Nunez

Fri 4/24

1:25 pm-8:06 am

2 stops17h 41m

$276

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Fri 5/8

4:19 pm-8:40 am

1 stop17h 21m

Cartagena Rafael Nunez

Mon 5/11

6:20 am-2:29 pm

1 stop7h 09m

$279

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Sun 4/12

4:18 pm-8:15 am

1 stop16h 57m

Medellín Jose Maria Cordova Intl

Sun 4/19

5:00 am-2:29 pm

1 stop8h 29m

$303

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Fri 5/8

6:00 am-9:10 pm

2 stops16h 10m

Medellín Jose Maria Cordova Intl

Wed 5/13

9:45 am-9:58 pm

1 stop11h 13m

$320

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 5/5

6:15 am-9:10 pm

1 stop15h 55m

Medellín Jose Maria Cordova Intl

Tue 5/12

9:45 am-9:58 pm

1 stop11h 13m

$330

RaleighGuayaquil

RDU - GYE

RDUGYE

Raleigh-Durham

Tue 4/7

6:00 am-2:40 pm

1 stop9h 40m

Guayaquil Jose Joaquin de Olmedo

Tue 4/28

4:00 pm-10:07 am

1 stop17h 07m

$347

RaleighGuayaquil

RDU - GYE

RDUGYE

Raleigh-Durham

Wed 4/1

7:46 pm-11:04 pm

1 stop28h 18m

Guayaquil Jose Joaquin de Olmedo

Wed 4/15

3:45 pm-8:18 am

2 stops15h 33m

$360

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from North Carolina to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from North Carolina to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $487. If you aren’t able to travel during the month of September, then book flights to South America from North Carolina during November instead. Flights to South America in November, while not as cheap as those in September, still average around $497.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $580 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from North Carolina for as low as $509 on momondo.

Can stopping save me money on North Carolina to South America flights?

You could potentially save up to 13% on your flight if you consider stops on a North Carolina to South America flight.

Cheap North Carolina to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to South America

Fastest flight time

5h 56m

Direct flights

None
The fastest flight from North Carolina to South America takes 5h 56m
There are no direct flights from North Carolina to South America. There are no popular flight routes from North Carolina to South America.
  • When did momondo last update prices for flights from North Carolina to South America?

    Prices for flights from North Carolina to South America are refreshed on a daily basis.

  • How many operators does momondo search for flights from North Carolina to South America?

  • How old do you have to be to fly from North Carolina to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from North Carolina to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from North Carolina to South America

Compare and see reviews for airlines that fly from North Carolina to South America with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $143Free CancellationRating
7.4
1,917 reviews
Search LATAM Airlines flights
Spirit AirlinesPriceFrom $149Free CancellationRating
6.3
8,498 reviews
Search Spirit Airlines flights
DeltaPriceFrom $163Free CancellationRating
7.9
8,270 reviews
Search Delta flights
Copa AirlinesPriceFrom $216Free CancellationRating
7.5
1,565 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $264Free CancellationRating
7.4
9,404 reviews
Search United Airlines flights
JetBluePriceFrom $268Free CancellationRating
7.2
2,895 reviews
Search JetBlue flights
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,395 reviews
Search American Airlines flights
GOLPriceFrom $447Free CancellationRating
7.3
1,181 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to South America?

It is quick and easy to find North Carolina to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from North Carolina to South America with flexible booking policies on momondo?

Flights from North Carolina to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from North Carolina to South America?

Once you have performed a search for North Carolina to South America flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from North Carolina to South America right now. Can momondo alert me if prices change?

Yes. momondo can track prices for North Carolina to South America flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your South America trip

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1 adult
Mon 4/6
Mon 4/13

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