Cheap flights from Missouri to Mexico from $134

If you’re not able to fly to Mexico in September, then October is your next best option. Flight prices from Missouri to Mexico during October average around $400.

The cheapest day to depart on your flight to Mexico is on a Monday when prices can be found for as low as $388. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $490. These prices are subject to change though, so be sure to set up a Price Alert for flights to Mexico.

Our data shows that the cheapest Missouri to Mexico flights are usually those with departure times in the morning. Our users have found flights to Mexico in the morning for as low as $432. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $590 on average. Flights to Mexico from Missouri at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Lambert-St Louis to Cancun for the best Missouri - Mexico flight prices

You are more likely to see cheaper flights to Mexico from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico from Missouri for as low as $368 on momondo.

There are 2 cabin classes available to choose from on Missouri to Mexico flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Delta, American Airlines, and Southwest are the most popular carriers operating from Missouri to Mexico

American Airlines, Frontier and Southwest are the top three most popular airlines that fly to Mexico from Missouri according to our data. American Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Mexico. Keep in mind that there are 10 different airlines that fly to Mexico on a routine basis, so you have a few additional options to choose from.

As of February 2026, there are 4 flights per day flying from Missouri to Mexico. The most common time of day flights depart is 6:00AM, with 89% of flights taking off at noon.

As of February 2026, there are 31 flights per week flying from Missouri to Mexico. The most common day of the week flights depart is Thu, with 19% of flights taking off on this day.