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Cheap flights from Mississippi to Knoxville from $45

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Knoxville departing on 10/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Mississippi to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:20 pm - 9:32 pmMEM  Memphis-TYS Knoxville McGhee Tyson
1h 12mnonstop
Allegiant Air Logo
7:45 pm - 8:04 pmTYS  Knoxville McGhee Tyson-MEM Memphis
1h 19mnonstop
$79Allegiant Air
Sun, Oct 4 - Fri, Oct 16
Allegiant Air Logo
8:22 pm - 10:34 pmMEM  Memphis-TYS Knoxville McGhee Tyson
1h 12mnonstop
Allegiant Air Logo
6:11 pm - 6:30 pmTYS  Knoxville McGhee Tyson-MEM Memphis
1h 19mnonstop
$90Allegiant Air
Fri, Oct 2 - Sun, Oct 4
Multiple Airlines Logo
7:58 pm - 5:53 pmMEM  Memphis-TYS Knoxville McGhee Tyson
20h 55m1 stop Tampa
Multiple Airlines Logo
6:11 pm - 6:30 pmTYS  Knoxville McGhee Tyson-MEM Memphis
1h 19mnonstop
$202Multiple Airlines
Fri, Oct 2 - Sun, Oct 4
Multiple Airlines Logo
7:58 pm - 5:53 pmMEM  Memphis-TYS Knoxville McGhee Tyson
20h 55m1 stop Tampa
Multiple Airlines Logo
6:11 pm - 6:30 pmTYS  Knoxville McGhee Tyson-MEM Memphis
1h 19mnonstop
$203Multiple Airlines
Fri, Oct 2 - Sun, Oct 4
American Airlines Logo
5:14 am - 12:28 pmMEM  Memphis-TYS Knoxville McGhee Tyson
6h 14m1 stop Charlotte Douglas
American Airlines Logo
7:58 pm - 11:55 pmTYS  Knoxville McGhee Tyson-MEM Memphis
4h 57m1 stop Charlotte Douglas
$239American Airlines
Wed, Oct 21 - Sat, Oct 24
Southwest Logo
2:55 pm - 6:40 pmMEM  Memphis-TYS Knoxville McGhee Tyson
2h 45m1 stop Nashville Intl
Southwest Logo
5:45 pm - 10:00 pmTYS  Knoxville McGhee Tyson-MEM Memphis
5h 15m1 stop Nashville Intl
$240Southwest
Mon, Sep 21 - Thu, Sep 24
Southwest Logo
7:00 am - 2:20 pmMEM  Memphis-TYS Knoxville McGhee Tyson
6h 20m2 stops Houston Hobby Dallas Love Field
Southwest Logo
1:55 pm - 5:50 pmTYS  Knoxville McGhee Tyson-MEM Memphis
4h 55m1 stop Dallas Love Field
$245Southwest
Wed, Sep 9 - Tue, Sep 15
American Airlines Logo
5:52 pm - 10:50 pmMEM  Memphis-TYS Knoxville McGhee Tyson
3h 58m1 stop Charlotte Douglas
American Airlines Logo
7:18 pm - 10:54 pmTYS  Knoxville McGhee Tyson-MEM Memphis
4h 36m1 stop Charlotte Douglas
$251American Airlines
Wed, Sep 9 - Tue, Sep 15
Delta Logo
3:11 pm - 9:50 pmMEM  Memphis-TYS Knoxville McGhee Tyson
5h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:06 pm - 2:30 pmTYS  Knoxville McGhee Tyson-MEM Memphis
3h 24m1 stop Atlanta Hartsfield-Jackson
$284Delta
Fri, Oct 2 - Tue, Oct 6
Delta Logo
3:53 pm - 10:22 pmMEM  Memphis-TYS Knoxville McGhee Tyson
5h 29m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:10 am - 10:54 amTYS  Knoxville McGhee Tyson-MEM Memphis
4h 44m1 stop Atlanta Hartsfield-Jackson
$284Delta
Mon, Nov 23 - Fri, Nov 27

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Allegiant Air flights from Mississippi to Knoxville

Our best Allegiant Air deals on Mississippi to Knoxville flight tickets
Allegiant Air
Oct 4
MEM7:20 pmMemphis
1h 12m
TYS9:32 pmKnoxville McGhee Tyson
Oct 16
TYS7:45 pmKnoxville McGhee Tyson
1h 19m
MEM8:04 pmMemphis
$79
Allegiant Air
Oct 2
MEM8:22 pmMemphis
1h 12m
TYS10:34 pmKnoxville McGhee Tyson
Oct 4
TYS6:11 pmKnoxville McGhee Tyson
1h 19m
MEM6:30 pmMemphis
$90
Allegiant Air
Oct 2
MEM8:22 pmMemphis
1h 12m
TYS10:34 pmKnoxville McGhee Tyson
Oct 4
TYS6:11 pmKnoxville McGhee Tyson
1h 19m
MEM6:30 pmMemphis
$91

American Airlines flights from Mississippi to Knoxville

Our best American Airlines deals on Mississippi to Knoxville flight tickets
American Airlines
Oct 21
MEM5:14 amMemphis
6h 14m
1 stop
TYS12:28 pmKnoxville McGhee Tyson
Oct 24
TYS7:58 pmKnoxville McGhee Tyson
4h 57m
1 stop
MEM11:55 pmMemphis
$239
American Airlines
Sep 9
MEM5:52 pmMemphis
3h 58m
1 stop
TYS10:50 pmKnoxville McGhee Tyson
Sep 15
TYS7:18 pmKnoxville McGhee Tyson
4h 36m
1 stop
MEM10:54 pmMemphis
$251
American Airlines
Sep 15
MEM8:14 amMemphis
6h 08m
1 stop
TYS3:22 pmKnoxville McGhee Tyson
Sep 18
TYS7:18 pmKnoxville McGhee Tyson
4h 36m
1 stop
MEM10:54 pmMemphis
$270

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Sun 10/4

7:20 pm-9:32 pm

Nonstop1h 12m

Knoxville McGhee Tyson

Fri 10/16

7:45 pm-8:04 pm

Nonstop1h 19m

$79

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Fri 10/2

8:22 pm-10:34 pm

Nonstop1h 12m

Knoxville McGhee Tyson

Sun 10/4

6:11 pm-6:30 pm

Nonstop1h 19m

$90

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Fri 10/2

7:58 pm-5:53 pm

1 stop20h 55m

Knoxville McGhee Tyson

Sun 10/4

6:11 pm-6:30 pm

Nonstop1h 19m

$202

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Fri 10/2

7:58 pm-5:53 pm

1 stop20h 55m

Knoxville McGhee Tyson

Sun 10/4

6:11 pm-6:30 pm

Nonstop1h 19m

$203

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Wed 10/21

5:14 am-12:28 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 10/24

7:58 pm-11:55 pm

1 stop4h 57m

$239

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Mon 9/21

2:55 pm-6:40 pm

1 stop2h 45m

Knoxville McGhee Tyson

Thu 9/24

5:45 pm-10:00 pm

1 stop5h 15m

$240

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Wed 9/9

7:00 am-2:20 pm

2 stops6h 20m

Knoxville McGhee Tyson

Tue 9/15

1:55 pm-5:50 pm

1 stop4h 55m

$245

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Wed 9/9

5:52 pm-10:50 pm

1 stop3h 58m

Knoxville McGhee Tyson

Tue 9/15

7:18 pm-10:54 pm

1 stop4h 36m

$251

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Fri 10/2

3:11 pm-9:50 pm

1 stop5h 39m

Knoxville McGhee Tyson

Tue 10/6

12:06 pm-2:30 pm

1 stop3h 24m

$284

MemphisKnoxville

MEM Memphis - TYS Knoxville McGhee Tyson

MEMTYS

Memphis

Mon 11/23

3:53 pm-10:22 pm

1 stop5h 29m

Knoxville McGhee Tyson

Fri 11/27

7:10 am-10:54 am

1 stop4h 44m

$284

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Mississippi to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Mississippi, with most prices found around $335. If you aren’t able to travel during the month of September, then book flights to Knoxville from Mississippi during October instead. Flights to Knoxville in October, while not as cheap as those in September, still average around $403.

Cheap Mississippi to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Knoxville

Fastest flight time

1h 12m

Direct flights

Mon and Sat

Airports in Knoxville

1 airport
The fastest flight from Mississippi to Knoxville takes 1h 12m
Direct flights go from Mississippi to Knoxville on Monday and Saturday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From Mississippi there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Mississippi to Knoxville

  • When did momondo last update prices for flights from Mississippi to Knoxville McGhee Tyson Airport?

    Prices for flights from Mississippi to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Mississippi to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Mississippi to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mississippi to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Mississippi to Knoxville

Compare and see reviews for airlines that fly from Mississippi to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $234Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,911 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Knoxville?

It is quick and easy to find Mississippi to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Mississippi to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Mississippi. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mississippi to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Mississippi to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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