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Cheap flights from Mississippi to Knoxville from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Knoxville departing on 3/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Mississippi to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:00 pm - 9:48 pm
MEM
-
TYS
25h 48m
1 stop
Multiple Airlines Logo
1:15 pm - 10:15 am
TYS
-
MEM
22h 00m
1 stop
$255Multiple Airlines
Thu, Apr 9 - Mon, Apr 13
Multiple Airlines Logo
11:14 am - 5:22 pm
MEM
-
TYS
29h 08m
2 stops
Multiple Airlines Logo
2:06 pm - 10:15 am
TYS
-
MEM
21h 09m
1 stop
$264Multiple Airlines
Wed, Mar 18 - Mon, Mar 23
American Airlines Logo
5:00 am - 11:31 am
BTR
-
TYS
5h 31m
1 stop
American Airlines Logo
5:02 pm - 9:55 pm
TYS
-
BTR
5h 53m
1 stop
$269American Airlines
Sat, Feb 28 - Wed, Mar 11
Allegiant Air Logo
7:00 pm - 9:48 pm
MEM
-
TYS
25h 48m
1 stop
Allegiant Air Logo
1:14 pm - 6:10 pm
TYS
-
MEM
5h 56m
1 stop
$271Allegiant Air
Thu, Apr 9 - Sun, Apr 12
American Airlines Logo
5:00 am - 11:31 am
BTR
-
TYS
5h 31m
1 stop
American Airlines Logo
5:40 am - 9:54 am
TYS
-
BTR
5h 14m
1 stop
$274American Airlines
Thu, Feb 26 - Sun, Mar 1
Allegiant Air Logo
8:04 am - 6:32 pm
MEM
-
TYS
9h 28m
1 stop
Allegiant Air Logo
1:54 pm - 2:05 pm
TYS
-
MEM
25h 11m
1 stop
$276Allegiant Air
Fri, Feb 20 - Sat, Feb 21
Delta Logo
6:18 am - 11:08 am
BTR
-
TYS
3h 50m
1 stop
Delta Logo
5:35 am - 9:46 am
TYS
-
BTR
5h 11m
1 stop
$279Delta
Sat, Feb 21 - Wed, Feb 25
Delta Logo
7:05 pm - 11:57 pm
BTR
-
TYS
3h 52m
1 stop
Delta Logo
6:38 pm - 10:03 pm
TYS
-
BTR
4h 25m
1 stop
$304Delta
Thu, Apr 2 - Mon, Apr 6
Southwest Logo
12:20 pm - 9:15 pm
JAN
-
TYS
7h 55m
1 stop
Southwest Logo
7:50 am - 7:40 pm
TYS
-
JAN
12h 50m
2 stops
$378Southwest
Thu, Mar 19 - Mon, Mar 23
Southwest Logo
5:30 am - 12:45 pm
JAN
-
TYS
6h 15m
2 stops
Southwest Logo
7:50 am - 7:40 pm
TYS
-
JAN
12h 50m
2 stops
$433Southwest
Thu, Mar 19 - Mon, Mar 23

American Airlines flights from Mississippi to Knoxville

Our best American Airlines deals on Mississippi to Knoxville flight tickets
American Airlines
Feb 28
BTR5:00 amBaton Rouge Ryan
5h 31m
1 stop
TYS11:31 amKnoxville McGhee Tyson
Mar 11
TYS5:02 pmKnoxville McGhee Tyson
5h 53m
1 stop
BTR9:55 pmBaton Rouge Ryan
$269
American Airlines
Feb 26
BTR5:00 amBaton Rouge Ryan
5h 31m
1 stop
TYS11:31 amKnoxville McGhee Tyson
Mar 1
TYS5:40 amKnoxville McGhee Tyson
5h 14m
1 stop
BTR9:54 amBaton Rouge Ryan
$274
American Airlines
Feb 21
BTR5:00 amBaton Rouge Ryan
9h 49m
2 stops
TYS3:49 pmKnoxville McGhee Tyson
Feb 25
TYS6:21 pmKnoxville McGhee Tyson
5h 18m
1 stop
BTR10:39 pmBaton Rouge Ryan
$284

Southwest flights from Mississippi to Knoxville

Our best Southwest deals on Mississippi to Knoxville flight tickets
Southwest
Mar 9
MEM5:05 pmMemphis
3h 10m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Mar 16
TYS7:25 pmKnoxville McGhee Tyson
5h 00m
1 stop
MEM11:25 pmMemphis
$299
Southwest
May 5
MEM9:45 amMemphis
6h 25m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
May 9
TYS7:45 amKnoxville McGhee Tyson
7h 15m
2 stops
MEM2:00 pmMemphis
$371
Southwest
Mar 19
JAN12:20 pmJackson-Evers Intl
7h 55m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Mar 23
TYS7:50 amKnoxville McGhee Tyson
12h 50m
2 stops
JAN7:40 pmJackson-Evers Intl
$378

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 4/9

7:00 pm-9:48 pm

1 stop25h 48m

Knoxville McGhee Tyson

Mon 4/13

1:15 pm-10:15 am

1 stop22h 00m

$255

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Wed 3/18

11:14 am-5:22 pm

2 stops29h 08m

Knoxville McGhee Tyson

Mon 3/23

2:06 pm-10:15 am

1 stop21h 09m

$264

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sat 2/28

5:00 am-11:31 am

1 stop5h 31m

Knoxville McGhee Tyson

Wed 3/11

5:02 pm-9:55 pm

1 stop5h 53m

$269

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 4/9

7:00 pm-9:48 pm

1 stop25h 48m

Knoxville McGhee Tyson

Sun 4/12

1:14 pm-6:10 pm

1 stop5h 56m

$271

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Thu 2/26

5:00 am-11:31 am

1 stop5h 31m

Knoxville McGhee Tyson

Sun 3/1

5:40 am-9:54 am

1 stop5h 14m

$274

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 2/20

8:04 am-6:32 pm

1 stop9h 28m

Knoxville McGhee Tyson

Sat 2/21

1:54 pm-2:05 pm

1 stop25h 11m

$276

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sat 2/21

6:18 am-11:08 am

1 stop3h 50m

Knoxville McGhee Tyson

Wed 2/25

5:35 am-9:46 am

1 stop5h 11m

$279

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Thu 4/2

7:05 pm-11:57 pm

1 stop3h 52m

Knoxville McGhee Tyson

Mon 4/6

6:38 pm-10:03 pm

1 stop4h 25m

$304

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Thu 3/19

12:20 pm-9:15 pm

1 stop7h 55m

Knoxville McGhee Tyson

Mon 3/23

7:50 am-7:40 pm

2 stops12h 50m

$378

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Thu 3/19

5:30 am-12:45 pm

2 stops6h 15m

Knoxville McGhee Tyson

Mon 3/23

7:50 am-7:40 pm

2 stops12h 50m

$433

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Mississippi to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Mississippi, with most prices found around $248. If you aren’t able to travel during the month of July, then book flights to Knoxville from Mississippi during March instead. Flights to Knoxville in March, while not as cheap as those in July, still average around $288.

Can stopping save me money on Mississippi to Knoxville flights?

You could potentially save up to 49% on your flight if you consider stops on a Mississippi to Knoxville flight.

Cheap Mississippi to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Knoxville

Fastest flight time

3h 43m

Direct flights

None
The fastest flight from Mississippi to Knoxville takes 3h 43m
There are no direct flights from Mississippi to Knoxville. There are no popular flight routes from Mississippi to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from Mississippi to Knoxville McGhee Tyson Airport?

    Prices for flights from Mississippi to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Mississippi to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Mississippi to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mississippi to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Mississippi to Knoxville

Compare and see reviews for airlines that fly from Mississippi to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $153Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
DeltaPriceFrom $164Free CancellationRating
7.9
8,174 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Knoxville?

It is quick and easy to find Mississippi to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Mississippi to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Mississippi. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mississippi to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Mississippi to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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