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Cheap flights from Mississippi to Florence from $515

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Florence departing on 12/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Mississippi to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 am - 12:26 pm
MEM
-
FLO
6h 26m
1 stop
American Airlines Logo
5:15 am - 8:47 am
FLO
-
MEM
4h 32m
1 stop
$515American Airlines
Mon, Dec 21 - Thu, Dec 31
American Airlines Logo
6:58 pm - 12:15 am
MEM
-
FLO
4h 17m
1 stop
American Airlines Logo
5:15 am - 8:47 am
FLO
-
MEM
4h 32m
1 stop
$517American Airlines
Tue, Dec 22 - Sat, Jan 2
American Airlines Logo
7:05 am - 12:26 pm
MEM
-
FLO
4h 21m
1 stop
American Airlines Logo
12:51 pm - 11:59 pm
FLO
-
MEM
12h 08m
2 stops
$595American Airlines
Mon, Dec 21 - Thu, Dec 31
American Airlines Logo
5:12 am - 6:05 pm
MEM
-
FLO
11h 53m
2 stops
American Airlines Logo
5:15 am - 8:47 am
FLO
-
MEM
4h 32m
1 stop
$628American Airlines
Tue, Dec 22 - Sat, Jan 2
American Airlines Logo
12:01 pm - 12:15 am
MEM
-
FLO
11h 14m
2 stops
American Airlines Logo
5:15 am - 3:20 pm
FLO
-
MEM
11h 05m
2 stops
$675American Airlines
Mon, Dec 21 - Thu, Dec 31
American Airlines Logo
5:12 am - 6:05 pm
MEM
-
FLO
11h 53m
2 stops
American Airlines Logo
5:15 am - 4:21 pm
FLO
-
MEM
12h 06m
2 stops
$828American Airlines
Tue, Dec 22 - Sat, Jan 2
American Airlines Logo
4:24 pm - 11:37 pm
JAN
-
FLO
6h 13m
1 stop
American Airlines Logo
2:35 pm - 10:28 am
FLO
-
JAN
20h 53m
1 stop
$953American Airlines
Mon, Jul 13 - Fri, Jul 17
American Airlines Logo
4:24 pm - 11:37 pm
JAN
-
FLO
6h 13m
1 stop
American Airlines Logo
2:35 pm - 12:11 am
FLO
-
JAN
10h 36m
2 stops
$1,375American Airlines
Mon, Jul 13 - Fri, Jul 17
American Airlines Logo
6:00 am - 11:37 pm
JAN
-
FLO
16h 37m
2 stops
American Airlines Logo
2:35 pm - 12:11 am
FLO
-
JAN
10h 36m
2 stops
$1,927American Airlines
Mon, Jul 13 - Fri, Jul 17

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American Airlines flights from Mississippi to Florence, South Carolina

Our best American Airlines deals on Mississippi to Florence, South Carolina flight tickets
American Airlines
Dec 21
MEM5:00 amMemphis
6h 26m
1 stop
FLO12:26 pmFlorence
Dec 31
FLO5:15 amFlorence
4h 32m
1 stop
MEM8:47 amMemphis
$515
American Airlines
Dec 22
MEM6:58 pmMemphis
4h 17m
1 stop
FLO12:15 amFlorence
Jan 2
FLO5:15 amFlorence
4h 32m
1 stop
MEM8:47 amMemphis
$517
American Airlines
Dec 21
MEM7:05 amMemphis
4h 21m
1 stop
FLO12:26 pmFlorence
Dec 31
FLO12:51 pmFlorence
12h 08m
2 stops
MEM11:59 pmMemphis
$595

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 29, 2026.
Use the filters below to find and compare flights from Mississippi to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/21

5:00 am-12:26 pm

1 stop6h 26m

Florence

Thu 12/31

5:15 am-8:47 am

1 stop4h 32m

$515
Quickest round-trip

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 12/22

6:58 pm-12:15 am

1 stop4h 17m

Florence

Sat 1/2

5:15 am-8:47 am

1 stop4h 32m

$517

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/21

7:05 am-12:26 pm

1 stop4h 21m

Florence

Thu 12/31

12:51 pm-11:59 pm

2 stops12h 08m

$595

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 12/22

5:12 am-6:05 pm

2 stops11h 53m

Florence

Sat 1/2

5:15 am-8:47 am

1 stop4h 32m

$628

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/21

12:01 pm-12:15 am

2 stops11h 14m

Florence

Thu 12/31

5:15 am-3:20 pm

2 stops11h 05m

$675

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 12/22

5:12 am-6:05 pm

2 stops11h 53m

Florence

Sat 1/2

5:15 am-4:21 pm

2 stops12h 06m

$828

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 7/13

4:24 pm-11:37 pm

1 stop6h 13m

Florence

Fri 7/17

2:35 pm-10:28 am

1 stop20h 53m

$953

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 7/13

4:24 pm-11:37 pm

1 stop6h 13m

Florence

Fri 7/17

2:35 pm-12:11 am

2 stops10h 36m

$1,375

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 7/13

6:00 am-11:37 pm

2 stops16h 37m

Florence

Fri 7/17

2:35 pm-12:11 am

2 stops10h 36m

$1,927

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Mississippi to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Florence, South Carolina from Mississippi according to our data. American Airlines is the first choice among our users, with 61% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 3 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Mississippi to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Florence, South Carolina

Fastest flight time

3h 44m

Direct flights

None
The fastest flight from Mississippi to Florence, South Carolina takes 3h 44m
There are no direct flights from Mississippi to Florence, South Carolina. There are no popular flight routes from Mississippi to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Mississippi to Florence, South Carolina

  • When did momondo last update prices for flights from Mississippi to Florence Airport?

    Prices for flights from Mississippi to Florence Airport were last updated today.

  • How old do you have to be to fly from Mississippi to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mississippi to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Florence?

Finding the right flight to Florence from Mississippi is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Mississippi to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Florence?

Once you have performed a search for Mississippi to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Mississippi to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Mississippi. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florence, South Carolina trip

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