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Cheap flights from Mississippi to Des Moines from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Des Moines departing on 7/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Mississippi to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:10 am - 1:21 pm
MEM
-
DSM
7h 11m
1 stop
American Airlines Logo
5:12 am - 11:11 am
DSM
-
MEM
5h 59m
1 stop
$287American Airlines
Wed, Jul 1 - Tue, Jul 7
Southwest Logo
5:20 am - 11:30 am
MEM
-
DSM
6h 10m
1 stop
Southwest Logo
3:50 pm - 10:25 pm
DSM
-
MEM
6h 35m
1 stop
$303Southwest
Wed, Jul 29 - Mon, Aug 10
Allegiant Air Logo
8:40 pm - 10:15 pm
MEM
-
DSM
25h 35m
1 stop
Allegiant Air Logo
3:20 pm - 7:50 pm
DSM
-
MEM
28h 30m
1 stop
$305Allegiant Air
Sun, Jul 12 - Sat, Jul 18
American Airlines Logo
6:38 pm - 12:12 am
GPT
-
DSM
5h 34m
1 stop
American Airlines Logo
5:12 am - 10:55 am
DSM
-
GPT
5h 43m
1 stop
$309American Airlines
Tue, Jun 30 - Tue, Jul 7
American Airlines Logo
6:16 pm - 11:58 pm
BTR
-
DSM
5h 42m
1 stop
American Airlines Logo
4:48 pm - 10:07 pm
DSM
-
BTR
5h 19m
1 stop
$309American Airlines
Wed, Jul 1 - Wed, Jul 8
Delta Logo
5:57 pm - 10:29 pm
GPT
-
DSM
4h 32m
1 stop
Delta Logo
2:45 pm - 10:14 pm
DSM
-
GPT
7h 29m
2 stops
$314Delta
Tue, Jul 21 - Tue, Jul 28
United Airlines Logo
6:09 pm - 10:35 pm
BTR
-
DSM
4h 26m
1 stop
United Airlines Logo
6:00 am - 5:33 pm
DSM
-
BTR
11h 33m
2 stops
$314United Airlines
Fri, Aug 7 - Wed, Aug 12
United Airlines Logo
6:35 pm - 10:56 pm
MEM
-
DSM
4h 21m
1 stop
United Airlines Logo
6:50 pm - 11:21 pm
DSM
-
MEM
4h 31m
1 stop
$317United Airlines
Sun, Jul 26 - Wed, Jul 29
Southwest Logo
5:10 am - 11:25 am
MEM
-
DSM
6h 15m
1 stop
Southwest Logo
5:20 am - 3:00 pm
DSM
-
MEM
9h 40m
2 stops
$322Southwest
Sun, Jul 26 - Wed, Jul 29
Delta Logo
6:05 am - 10:45 am
MOB
-
DSM
4h 40m
1 stop
Delta Logo
6:37 pm - 11:25 pm
DSM
-
MOB
4h 48m
1 stop
$323Delta
Sat, Jul 25 - Mon, Jul 27

American Airlines flights from Mississippi to Des Moines

Our best American Airlines deals on Mississippi to Des Moines flight tickets
American Airlines
Jul 1
MEM6:10 amMemphis
7h 11m
1 stop
DSM1:21 pmDes Moines
Jul 7
DSM5:12 amDes Moines
5h 59m
1 stop
MEM11:11 amMemphis
$287
American Airlines
Jun 30
GPT6:38 pmGulfport Biloxi Regional
5h 34m
1 stop
DSM12:12 amDes Moines
Jul 7
DSM5:12 amDes Moines
5h 43m
1 stop
GPT10:55 amGulfport Biloxi Regional
$309
American Airlines
Jul 1
GPT6:38 pmGulfport Biloxi Regional
5h 29m
1 stop
DSM12:07 amDes Moines
Jul 7
DSM5:12 amDes Moines
5h 43m
1 stop
GPT10:55 amGulfport Biloxi Regional
$324

United Airlines flights from Mississippi to Des Moines

Our best United Airlines deals on Mississippi to Des Moines flight tickets
United Airlines
Aug 7
BTR6:09 pmBaton Rouge Ryan
4h 26m
1 stop
DSM10:35 pmDes Moines
Aug 12
DSM6:00 amDes Moines
11h 33m
2 stops
BTR5:33 pmBaton Rouge Ryan
$314
United Airlines
Jul 26
MEM6:35 pmMemphis
4h 21m
1 stop
DSM10:56 pmDes Moines
Jul 29
DSM6:50 pmDes Moines
4h 31m
1 stop
MEM11:21 pmMemphis
$317
United Airlines
Aug 15
MEM4:33 pmMemphis
7h 11m
1 stop
DSM11:44 pmDes Moines
Aug 16
DSM6:00 amDes Moines
5h 03m
1 stop
MEM11:03 amMemphis
$328

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 6, 2026.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/1

6:10 am-1:21 pm

1 stop7h 11m

Des Moines

Tue 7/7

5:12 am-11:11 am

1 stop5h 59m

$287

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/29

5:20 am-11:30 am

1 stop6h 10m

Des Moines

Mon 8/10

3:50 pm-10:25 pm

1 stop6h 35m

$303

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 7/12

8:40 pm-10:15 pm

1 stop25h 35m

Des Moines

Sat 7/18

3:20 pm-7:50 pm

1 stop28h 30m

$305

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Tue 6/30

6:38 pm-12:12 am

1 stop5h 34m

Des Moines

Tue 7/7

5:12 am-10:55 am

1 stop5h 43m

$309

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 7/1

6:16 pm-11:58 pm

1 stop5h 42m

Des Moines

Wed 7/8

4:48 pm-10:07 pm

1 stop5h 19m

$309

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Tue 7/21

5:57 pm-10:29 pm

1 stop4h 32m

Des Moines

Tue 7/28

2:45 pm-10:14 pm

2 stops7h 29m

$314

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 8/7

6:09 pm-10:35 pm

1 stop4h 26m

Des Moines

Wed 8/12

6:00 am-5:33 pm

2 stops11h 33m

$314
Quickest round-trip

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 7/26

6:35 pm-10:56 pm

1 stop4h 21m

Des Moines

Wed 7/29

6:50 pm-11:21 pm

1 stop4h 31m

$317

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 7/26

5:10 am-11:25 am

1 stop6h 15m

Des Moines

Wed 7/29

5:20 am-3:00 pm

2 stops9h 40m

$322

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Sat 7/25

6:05 am-10:45 am

1 stop4h 40m

Des Moines

Mon 7/27

6:37 pm-11:25 pm

1 stop4h 48m

$323

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Mississippi to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Mississippi to Des Moines flights?

You could potentially save up to 59% on your flight if you consider stops on a Mississippi to Des Moines flight.

Cheap Mississippi to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Des Moines

Fastest flight time

4h 21m

Direct flights

None
The fastest flight from Mississippi to Des Moines takes 4h 21m
There are no direct flights from Mississippi to Des Moines. There are no popular flight routes from Mississippi to Des Moines.
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Frequently asked questions about flying from Mississippi to Des Moines

  • When did momondo last update prices for flights from Mississippi to Des Moines Airport?

    Prices for flights from Mississippi to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Mississippi to Des Moines Airport?

  • How old do you have to be to fly from Mississippi to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mississippi to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Mississippi to Des Moines

Compare and see reviews for airlines that fly from Mississippi to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $124Free CancellationRating
7.8
8,395 reviews
Search Delta flights
American AirlinesPriceFrom $307Free CancellationRating
7.1
11,651 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Osceola
Johnston
Newton
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Mississippi to Des Moines for you.

Can I find flights from Mississippi to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Mississippi to Des Moines.

I’m not ready to book a flight from Mississippi to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Mississippi to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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