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Cheap flights from Mississippi to Des Moines from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Des Moines departing on 2/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Mississippi to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
4:50 pm - 10:30 pm
MOB
-
DSM
5h 40m1 stop
United Airlines Logo
3:04 pm - 9:59 pm
DSM
-
MOB
6h 55m1 stop
$279United Airlines
Fri, Jan 9 - Tue, Jan 13
United Airlines Logo
4:50 pm - 10:30 pm
MOB
-
DSM
5h 40m1 stop
United Airlines Logo
8:00 am - 6:24 pm
DSM
-
MOB
10h 24m2 stops
$284United Airlines
Fri, Jan 9 - Tue, Jan 13
United Airlines Logo
10:44 am - 9:50 pm
MOB
-
DSM
11h 06m2 stops
United Airlines Logo
5:30 am - 4:09 pm
DSM
-
MOB
10h 39m2 stops
$289United Airlines
Fri, Jan 9 - Tue, Jan 13
United Airlines Logo
7:30 am - 2:27 pm
MEM
-
DSM
6h 57m1 stop
United Airlines Logo
3:24 pm - 9:59 pm
DSM
-
MEM
6h 35m1 stop
$289United Airlines
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
8:37 am - 4:24 pm
MEM
-
DSM
7h 47m2 stops
American Airlines Logo
4:00 pm - 10:51 pm
DSM
-
MEM
6h 51m1 stop
$295American Airlines
Sun, Feb 1 - Sat, Feb 7
American Airlines Logo
10:27 am - 8:02 pm
MEM
-
DSM
9h 35m2 stops
American Airlines Logo
6:00 am - 3:18 pm
DSM
-
MEM
9h 18m2 stops
$300American Airlines
Sun, Feb 1 - Sat, Feb 7
Southwest Logo
5:10 am - 11:25 am
MEM
-
DSM
6h 15m1 stop
Southwest Logo
5:20 am - 3:00 pm
DSM
-
MEM
9h 40m2 stops
$362Southwest
Sun, Jun 14 - Wed, Jun 17
Delta Logo
6:00 am - 12:15 pm
GTR
-
DSM
6h 15m1 stop
Delta Logo
5:35 am - 12:47 pm
DSM
-
GTR
7h 12m1 stop
$376Delta
Sat, Jan 24 - Sat, Jan 31
Southwest Logo
5:10 am - 3:35 pm
MEM
-
DSM
10h 25m2 stops
Southwest Logo
5:20 am - 3:00 pm
DSM
-
MEM
9h 40m2 stops
$377Southwest
Sun, Jun 14 - Wed, Jun 17
Delta Logo
6:00 am - 12:15 pm
GTR
-
DSM
6h 15m1 stop
Delta Logo
12:25 pm - 8:25 pm
DSM
-
GTR
8h 00m2 stops
$382Delta
Sat, Jan 24 - Sat, Jan 31

United Airlines flights from Mississippi to Des Moines

Our best United Airlines deals on Mississippi to Des Moines flight tickets
United Airlines
Jan 9
MOB4:50 pmMobile
5h 40m
1 stop
DSM10:30 pmDes Moines
Jan 13
DSM3:04 pmDes Moines
6h 55m
1 stop
MOB9:59 pmMobile
$279
Find similar
United Airlines
Jan 9
MOB4:50 pmMobile
5h 40m
1 stop
DSM10:30 pmDes Moines
Jan 13
DSM8:00 amDes Moines
10h 24m
2 stops
MOB6:24 pmMobile
$284
Find similar
United Airlines
Jan 9
MOB10:44 amMobile
11h 06m
2 stops
DSM9:50 pmDes Moines
Jan 13
DSM5:30 amDes Moines
10h 39m
2 stops
MOB4:09 pmMobile
$289
Find similar

Southwest flights from Mississippi to Des Moines

Our best Southwest deals on Mississippi to Des Moines flight tickets
Southwest
Jun 14
MEM5:10 amMemphis
6h 15m
1 stop
DSM11:25 amDes Moines
Jun 17
DSM5:20 amDes Moines
9h 40m
2 stops
MEM3:00 pmMemphis
$362
Find similar
Southwest
Jun 14
MEM5:10 amMemphis
10h 25m
2 stops
DSM3:35 pmDes Moines
Jun 17
DSM5:20 amDes Moines
9h 40m
2 stops
MEM3:00 pmMemphis
$377
Find similar
Southwest
May 21
MEM5:05 amMemphis
6h 40m
1 stop
DSM11:45 amDes Moines
May 24
DSM6:00 amDes Moines
11h 25m
2 stops
MEM5:25 pmMemphis
$378
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 1/9

4:50 pm-10:30 pm

1 stop5h 40m

Des Moines

Tue 1/13

3:04 pm-9:59 pm

1 stop6h 55m

$279

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 1/9

4:50 pm-10:30 pm

1 stop5h 40m

Des Moines

Tue 1/13

8:00 am-6:24 pm

2 stops10h 24m

$284

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 1/9

10:44 am-9:50 pm

2 stops11h 06m

Des Moines

Tue 1/13

5:30 am-4:09 pm

2 stops10h 39m

$289

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 2/14

7:30 am-2:27 pm

1 stop6h 57m

Des Moines

Wed 2/18

3:24 pm-9:59 pm

1 stop6h 35m

$289

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 2/1

8:37 am-4:24 pm

2 stops7h 47m

Des Moines

Sat 2/7

4:00 pm-10:51 pm

1 stop6h 51m

$295

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 2/1

10:27 am-8:02 pm

2 stops9h 35m

Des Moines

Sat 2/7

6:00 am-3:18 pm

2 stops9h 18m

$300

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 6/14

5:10 am-11:25 am

1 stop6h 15m

Des Moines

Wed 6/17

5:20 am-3:00 pm

2 stops9h 40m

$362

ColumbusDes Moines

GTR - DSM

GTRDSM

Columbus Golden Triangle Reg.

Sat 1/24

6:00 am-12:15 pm

1 stop6h 15m

Des Moines

Sat 1/31

5:35 am-12:47 pm

1 stop7h 12m

$376

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 6/14

5:10 am-3:35 pm

2 stops10h 25m

Des Moines

Wed 6/17

5:20 am-3:00 pm

2 stops9h 40m

$377

ColumbusDes Moines

GTR - DSM

GTRDSM

Columbus Golden Triangle Reg.

Sat 1/24

6:00 am-12:15 pm

1 stop6h 15m

Des Moines

Sat 1/31

12:25 pm-8:25 pm

2 stops8h 00m

$382

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Mississippi to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Mississippi to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $323. Flights from Mississippi to Des Moines on a Wednesday will generally be more expensive and average around $560. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

Cheap Mississippi to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Des Moines

Fastest flight time

4h 30m

Direct flights

None
The fastest flight from Mississippi to Des Moines takes 4h 30m
There are no direct flights from Mississippi to Des Moines. There are no popular flight routes from Mississippi to Des Moines.
Search flight deals

  • When did momondo last update prices for flights from Mississippi to Des Moines Airport?

    Prices for flights from Mississippi to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Mississippi to Des Moines Airport?

  • How old do you have to be to fly from Mississippi to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mississippi to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Mississippi to Des Moines

Compare and see reviews for airlines that fly from Mississippi to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $124Free CancellationRating
7.9
8,018 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Mississippi to Des Moines for you.

Can I find flights from Mississippi to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Mississippi to Des Moines.

I’m not ready to book a flight from Mississippi to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Mississippi to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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