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Cheap flights from Mississippi to Des Moines from $65

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mississippi to Des Moines departing on 12/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Mississippi to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:20 am - 4:49 pmBTR-DSM
6h 29m1 stop
American Airlines Logo
3:18 pm - 8:53 pmDSM-BTR
5h 35m1 stop
$249American Airlines
Find Deal
Fri, Dec 12 - Mon, Dec 15
American Airlines Logo
10:20 am - 4:49 pmBTR-DSM
6h 29m1 stop
American Airlines Logo
12:15 pm - 8:53 pmDSM-BTR
8h 38m2 stops
$254American Airlines
Find Deal
Fri, Dec 12 - Mon, Dec 15
Delta Logo
5:55 am - 10:16 amMOB-DSM
4h 21m1 stop
Delta Logo
5:45 am - 11:29 amDSM-MOB
5h 44m1 stop
$274Delta
Find Deal
Wed, Apr 15 - Sat, Apr 18
Delta Logo
6:03 pm - 10:33 pmGPT-DSM
4h 30m1 stop
Delta Logo
11:28 am - 5:13 pmDSM-GPT
5h 45m1 stop
$279Delta
Find Deal
Wed, Nov 19 - Sun, Nov 23
Southwest Logo
8:15 am - 7:20 pmMEM-DSM
11h 05m2 stops
Southwest Logo
12:05 pm - 7:55 pmDSM-MEM
7h 50m1 stop
$294Southwest
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Tue, Jan 20 - Fri, Jan 23
Multiple Airlines Logo
8:38 pm - 9:41 pmMEM-DSM
25h 03m1 stop
Multiple Airlines Logo
6:53 pm - 9:02 amDSM-MEM
38h 09m2 stops
$295Multiple Airlines
Find Deal
Sun, Nov 23 - Mon, Dec 1
Southwest Logo
2:45 pm - 9:10 pmMEM-DSM
6h 25m2 stops
Southwest Logo
6:10 am - 5:10 pmDSM-MEM
11h 00m2 stops
$299Southwest
Find Deal
Tue, Jan 20 - Fri, Jan 23
United Airlines Logo
4:08 pm - 10:20 pmBTR-DSM
6h 12m1 stop
United Airlines Logo
8:08 am - 1:18 pmDSM-BTR
5h 10m1 stop
$319United Airlines
Find Deal
Thu, Feb 19 - Mon, Feb 23
United Airlines Logo
11:35 am - 8:32 pmMOB-DSM
8h 57m2 stops
United Airlines Logo
3:00 pm - 9:29 pmDSM-MOB
6h 29m1 stop
$324United Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
Multiple Airlines Logo
8:38 pm - 9:41 pmMEM-DSM
25h 03m1 stop
Multiple Airlines Logo
12:16 pm - 8:21 pmDSM-MEM
8h 05m1 stop
$324Multiple Airlines
Find Deal
Sun, Nov 23 - Mon, Dec 1

Delta flights from Mississippi to Des Moines

Our best Delta deals on Mississippi to Des Moines flight tickets
Delta
Apr 15
MOB5:55 amMobile
4h 21m
1 stop
DSM10:16 amDes Moines
Apr 18
DSM5:45 amDes Moines
5h 44m
1 stop
MOB11:29 amMobile
$274
Find similar
Delta
Nov 19
GPT6:03 pmGulfport Biloxi Regional
4h 30m
1 stop
DSM10:33 pmDes Moines
Nov 23
DSM11:28 amDes Moines
5h 45m
1 stop
GPT5:13 pmGulfport Biloxi Regional
$279
Find similar
Delta
Nov 19
GPT6:03 pmGulfport Biloxi Regional
4h 30m
1 stop
DSM10:33 pmDes Moines
Nov 23
DSM6:17 amDes Moines
7h 51m
2 stops
GPT2:08 pmGulfport Biloxi Regional
$284
Find similar

American Airlines flights from Mississippi to Des Moines

Our best American Airlines deals on Mississippi to Des Moines flight tickets
American Airlines
Dec 12
BTR10:20 amBaton Rouge Ryan
6h 29m
1 stop
DSM4:49 pmDes Moines
Dec 15
DSM3:18 pmDes Moines
5h 35m
1 stop
BTR8:53 pmBaton Rouge Ryan
$249
Find similar
American Airlines
Dec 12
BTR10:20 amBaton Rouge Ryan
6h 29m
1 stop
DSM4:49 pmDes Moines
Dec 15
DSM12:15 pmDes Moines
8h 38m
2 stops
BTR8:53 pmBaton Rouge Ryan
$254
Find similar
American Airlines
Nov 19
GPT6:43 amGulfport Biloxi Regional
8h 49m
2 stops
DSM3:32 pmDes Moines
Nov 23
DSM1:47 pmDes Moines
10h 10m
2 stops
GPT11:57 pmGulfport Biloxi Regional
$289
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 12/12

10:20 am-4:49 pm

1 stop6h 29m

Des Moines

Mon 12/15

3:18 pm-8:53 pm

1 stop5h 35m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 12/12

10:20 am-4:49 pm

1 stop6h 29m

Des Moines

Mon 12/15

12:15 pm-8:53 pm

2 stops8h 38m

$254

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 4/15

5:55 am-10:16 am

1 stop4h 21m

Des Moines

Sat 4/18

5:45 am-11:29 am

1 stop5h 44m

$274

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Wed 11/19

6:03 pm-10:33 pm

1 stop4h 30m

Des Moines

Sun 11/23

11:28 am-5:13 pm

1 stop5h 45m

$279

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 1/20

8:15 am-7:20 pm

2 stops11h 05m

Des Moines

Fri 1/23

12:05 pm-7:55 pm

1 stop7h 50m

$294

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 11/23

8:38 pm-9:41 pm

1 stop25h 03m

Des Moines

Mon 12/1

6:53 pm-9:02 am

2 stops38h 09m

$295

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 1/20

2:45 pm-9:10 pm

2 stops6h 25m

Des Moines

Fri 1/23

6:10 am-5:10 pm

2 stops11h 00m

$299

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 2/19

4:08 pm-10:20 pm

1 stop6h 12m

Des Moines

Mon 2/23

8:08 am-1:18 pm

1 stop5h 10m

$319

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 4/15

11:35 am-8:32 pm

2 stops8h 57m

Des Moines

Sat 4/18

3:00 pm-9:29 pm

1 stop6h 29m

$324

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 11/23

8:38 pm-9:41 pm

1 stop25h 03m

Des Moines

Mon 12/1

12:16 pm-8:21 pm

1 stop8h 05m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Mississippi to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Mississippi to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $323. Flights from Mississippi to Des Moines on a Wednesday will generally be more expensive and average around $560. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Mississippi to Des Moines in the morning for as low as $351. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $458. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Mississippi to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mississippi to Des Moines

Direct flights

None
There are no direct flights from Mississippi to Des Moines. There are no popular flight routes from Mississippi to Des Moines.
Search flight deals

  • When did momondo last update prices for flights from Mississippi to Des Moines Airport?

    Prices for flights from Mississippi to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Mississippi to Des Moines Airport?

  • How old do you have to be to fly from Mississippi to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mississippi to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Mississippi to Des Moines

Compare and see reviews for airlines that fly from Mississippi to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $124Free CancellationRating
7.9
8,001 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Newton
Pella
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Mississippi to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Mississippi to Des Moines for you.

Can I find flights from Mississippi to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Mississippi on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mississippi to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Mississippi to Des Moines.

I’m not ready to book a flight from Mississippi to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Mississippi to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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