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Cheap flights from Mexico to Des Moines from $262

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico to Des Moines departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Mexico to Des Moines

Recent round-trip flight deals from Mexico to Des Moines

Enter your travel dates to find the best prices.
Aeromexico Logo
11:00 am - 4:27 pmCUN  Cancun-DSM Des Moines
6h 27m1 stop Atlanta Hartsfield-Jackson
Aeromexico Logo
7:00 am - 2:10 pmDSM  Des Moines-CUN Cancun
6h 10m1 stop Minneapolis St Paul
$463Aeromexico
Thu, Jan 21 - Mon, Jan 25
United Airlines Logo
1:43 pm - 10:36 amCUN  Cancun-DSM Des Moines
20h 53m3 stops Houston George Bush Intcntl Newark Chicago O'Hare Intl
United Airlines Logo
6:15 am - 2:37 pmDSM  Des Moines-CUN Cancun
8h 22m1 stop Houston George Bush Intcntl
$464United Airlines
Fri, Sep 11 - Tue, Sep 15
United Airlines Logo
8:39 am - 2:20 pmCUN  Cancun-DSM Des Moines
6h 41m1 stop Houston George Bush Intcntl
United Airlines Logo
8:00 am - 3:24 pmDSM  Des Moines-CUN Cancun
6h 24m1 stop Houston George Bush Intcntl
$465United Airlines
Thu, Jan 21 - Mon, Jan 25
Multiple Airlines Logo
7:58 am - 7:33 pmGDL  Guadalajara Miguel Hidal-DSM Des Moines
10h 35m1 stop Denver Intl
Multiple Airlines Logo
8:30 pm - 4:56 amDSM  Des Moines-GDL Guadalajara Miguel Hidal
33h 26m2 stops Denver Intl Los Angeles
$471Multiple Airlines
Fri, Sep 25 - Fri, Oct 2
Multiple Airlines Logo
8:40 am - 7:33 pmMEX  Mexico City Benito Juarez-DSM Des Moines
9h 53m1 stop Denver Intl
Multiple Airlines Logo
9:56 pm - 9:45 pmDSM  Des Moines-MEX Mexico City Benito Juarez
24h 49m1 stop Las Vegas Harry Reid Intl
$475Multiple Airlines
Fri, Sep 11 - Sun, Sep 20
Multiple Airlines Logo
8:40 am - 7:30 pmMEX  Mexico City Benito Juarez-DSM Des Moines
9h 50m1 stop Denver Intl
Multiple Airlines Logo
2:42 pm - 9:30 pmDSM  Des Moines-MEX Mexico City Benito Juarez
31h 48m2 stops Las Vegas Harry Reid Intl Monterrey Gen Mariano Escobedo
$484Multiple Airlines
Fri, Oct 16 - Wed, Oct 21
United Airlines Logo
8:39 am - 2:20 pmCUN  Cancun-DSM Des Moines
6h 41m1 stop Houston George Bush Intcntl
United Airlines Logo
8:00 am - 3:24 pmDSM  Des Moines-CUN Cancun
6h 24m1 stop Houston George Bush Intcntl
$486United Airlines
Thu, Jan 21 - Mon, Jan 25
Multiple Airlines Logo
8:40 am - 7:33 pmMEX  Mexico City Benito Juarez-DSM Des Moines
9h 53m1 stop Denver Intl
Multiple Airlines Logo
9:56 pm - 8:00 pmDSM  Des Moines-MEX Mexico City Benito Juarez
23h 04m2 stops Las Vegas Harry Reid Intl Guadalajara Miguel Hidal
$497Multiple Airlines
Fri, Sep 11 - Sun, Sep 20
Multiple Airlines Logo
8:40 am - 7:30 pmMEX  Mexico City Benito Juarez-DSM Des Moines
9h 50m1 stop Denver Intl
Multiple Airlines Logo
2:42 pm - 8:05 pmDSM  Des Moines-MEX Mexico City Benito Juarez
30h 23m1 stop Las Vegas Harry Reid Intl
$504Multiple Airlines
Fri, Oct 16 - Wed, Oct 21
United Airlines Logo
12:19 pm - 11:35 pmPVR  Puerto Vallarta Ordaz-DSM Des Moines
34h 16m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:55 pm - 11:10 amDSM  Des Moines-PVR Puerto Vallarta Ordaz
17h 15m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$511United Airlines
Thu, Sep 24 - Mon, Sep 28

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United Airlines flights from Mexico to Des Moines

Our best United Airlines deals on Mexico to Des Moines flight tickets
United Airlines
Sep 11
CUN1:43 pmCancun
20h 53m
3 stops
DSM10:36 amDes Moines
Sep 15
DSM6:15 amDes Moines
8h 22m
1 stop
CUN2:37 pmCancun
$464
United Airlines
Jan 21
CUN8:39 amCancun
6h 41m
1 stop
DSM2:20 pmDes Moines
Jan 25
DSM8:00 amDes Moines
6h 24m
1 stop
CUN3:24 pmCancun
$465
United Airlines
Jan 21
CUN8:39 amCancun
6h 41m
1 stop
DSM2:20 pmDes Moines
Jan 25
DSM8:00 amDes Moines
6h 24m
1 stop
CUN3:24 pmCancun
$486

American Airlines flights from Mexico to Des Moines

Our best American Airlines deals on Mexico to Des Moines flight tickets
American Airlines
Sep 27
MEX1:09 pmMexico City Benito Juarez
9h 55m
1 stop
DSM12:04 amDes Moines
Oct 4
DSM6:41 amDes Moines
10h 34m
1 stop
MEX4:15 pmMexico City Benito Juarez
$651
American Airlines
Sep 4
MEX1:10 pmMexico City Benito Juarez
18h 51m
1 stop
DSM9:01 amDes Moines
Sep 8
DSM6:22 pmDes Moines
18h 38m
1 stop
MEX12:00 pmMexico City Benito Juarez
$659
American Airlines
Aug 18
PVR2:58 pmPuerto Vallarta Ordaz
17h 03m
2 stops
DSM9:01 amDes Moines
Aug 21
DSM6:22 pmDes Moines
20h 41m
2 stops
PVR2:03 pmPuerto Vallarta Ordaz
$684

momondo Fare Finder

 
Customize your flight search to find flights from Mexico to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Mexico to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

CancúnDes Moines

CUN Cancun - DSM Des Moines

CUNDSM

Cancun

Thu 1/21

11:00 am-4:27 pm

1 stop6h 27m

Des Moines

Mon 1/25

7:00 am-2:10 pm

1 stop6h 10m

$463

CancúnDes Moines

CUN Cancun - DSM Des Moines

CUNDSM

Cancun

Fri 9/11

1:43 pm-10:36 am

3 stops20h 53m

Des Moines

Tue 9/15

6:15 am-2:37 pm

1 stop8h 22m

$464

CancúnDes Moines

CUN Cancun - DSM Des Moines

CUNDSM

Cancun

Thu 1/21

8:39 am-2:20 pm

1 stop6h 41m

Des Moines

Mon 1/25

8:00 am-3:24 pm

1 stop6h 24m

$465

GuadalajaraDes Moines

GDL Guadalajara Miguel Hidal - DSM Des Moines

GDLDSM

Guadalajara Miguel Hidal

Fri 9/25

7:58 am-7:33 pm

1 stop10h 35m

Des Moines

Fri 10/2

8:30 pm-4:56 am

2 stops33h 26m

$471

Mexico CityDes Moines

MEX Mexico City Benito Juarez - DSM Des Moines

MEXDSM

Mexico City Benito Juarez

Fri 9/11

8:40 am-7:33 pm

1 stop9h 53m

Des Moines

Sun 9/20

9:56 pm-9:45 pm

1 stop24h 49m

$475

Mexico CityDes Moines

MEX Mexico City Benito Juarez - DSM Des Moines

MEXDSM

Mexico City Benito Juarez

Fri 10/16

8:40 am-7:30 pm

1 stop9h 50m

Des Moines

Wed 10/21

2:42 pm-9:30 pm

2 stops31h 48m

$484

CancúnDes Moines

CUN Cancun - DSM Des Moines

CUNDSM

Cancun

Thu 1/21

8:39 am-2:20 pm

1 stop6h 41m

Des Moines

Mon 1/25

8:00 am-3:24 pm

1 stop6h 24m

$486

Mexico CityDes Moines

MEX Mexico City Benito Juarez - DSM Des Moines

MEXDSM

Mexico City Benito Juarez

Fri 9/11

8:40 am-7:33 pm

1 stop9h 53m

Des Moines

Sun 9/20

9:56 pm-8:00 pm

2 stops23h 04m

$497

Mexico CityDes Moines

MEX Mexico City Benito Juarez - DSM Des Moines

MEXDSM

Mexico City Benito Juarez

Fri 10/16

8:40 am-7:30 pm

1 stop9h 50m

Des Moines

Wed 10/21

2:42 pm-8:05 pm

1 stop30h 23m

$504

Puerto VallartaDes Moines

PVR Puerto Vallarta Ordaz - DSM Des Moines

PVRDSM

Puerto Vallarta Ordaz

Thu 9/24

12:19 pm-11:35 pm

2 stops34h 16m

Des Moines

Mon 9/28

6:55 pm-11:10 am

2 stops17h 15m

$511

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Mexico to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in April, then September is your next best option. Flight prices from Mexico to Des Moines during September average around $526.

Can stopping save me money on Mexico to Des Moines flights?

You could potentially save up to 30% on your flight if you consider stops on a Mexico to Des Moines flight.

Cheap Mexico to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico to Des Moines

Fastest flight time

6h 41m

Direct flights

None
The fastest flight from Mexico to Des Moines takes 6h 41m
There are no direct flights from Mexico to Des Moines. There are no popular flight routes from Mexico to Des Moines.
Search flight deals

Frequently asked questions about flying from Mexico to Des Moines

  • When did momondo last update prices for flights from Mexico to Des Moines Airport?

    Prices for flights from Mexico to Des Moines Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Mexico to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mexico to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Mexico to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Mexico.

Can I find flights from Mexico to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Mexico on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Mexico to Des Moines?

momondo helps you find the best flight between Mexico and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Mexico to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Mexico to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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