What is the cheapest airline that flies from Louisville Intl to South America?

American Airlines, Copa Airlines, and LATAM Airlines are the most popular carriers operating from Louisville Intl to South America

What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Louisville according to our data. Delta is the first choice among our users, with 41% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 5 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Louisville Intl Airport to South America?

Prices for flights from Louisville Intl Airport to South America were last updated today.

How many operators does momondo search for flights from Louisville Intl Airport to South America?

As of October 2026, there are 4 operators available to choose from for flights from Louisville Intl Airport to South America.

How old do you have to be to fly from Louisville Intl Airport to South America?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$303 Cheap Flights from Louisville to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Louisville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:16 pm - 3:36 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez

22h 20m2 stops Washington, D.C. Reagan-National Miami

2:35 pm - 9:38 amCTG Cartagena Rafael Nunez-SDF Louisville Intl

19h 03m2 stops Miami Chicago O'Hare Intl

$573American Airlines

Sat, Oct 31 - Wed, Nov 4

6:00 am - 12:35 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez

7h 35m1 stop Miami

1:35 pm - 11:22 amCTG Cartagena Rafael Nunez-SDF Louisville Intl

20h 47m2 stops Miami Dallas/Fort Worth

$573American Airlines

Sun, Oct 25 - Sat, Oct 31

7:00 am - 2:10 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez

7h 10m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 12:02 amCTG Cartagena Rafael Nunez-SDF Louisville Intl

8h 32m1 stop Atlanta Hartsfield-Jackson

$584Delta

Wed, Mar 3 - Mon, Mar 8

7:00 am - 2:10 pmSDF Louisville Intl-CTG Cartagena Rafael Nunez

7h 10m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 12:02 amCTG Cartagena Rafael Nunez-SDF Louisville Intl

8h 32m1 stop Atlanta Hartsfield-Jackson

$585Delta

Wed, Mar 3 - Mon, Mar 8

8:50 am - 12:30 amSDF Louisville Intl-UIO Quito Mariscal Sucr

15h 40m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

1:35 am - 4:35 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

15h 00m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$662United Airlines

Wed, Jan 13 - Tue, Jan 19

7:00 am - 12:30 amSDF Louisville Intl-UIO Quito Mariscal Sucr

17h 30m1 stop Houston George Bush Intcntl

1:35 am - 6:29 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

16h 54m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$662United Airlines

Wed, Jan 13 - Tue, Jan 19

10:13 am - 11:00 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

12h 47m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

7:05 am - 9:06 amUIO Quito Mariscal Sucr-SDF Louisville Intl

26h 01m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$668LATAM Airlines

Sun, Nov 15 - Sun, Nov 22

7:00 am - 6:59 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

12h 59m1 stop Atlanta Hartsfield-Jackson

7:05 am - 9:54 amUIO Quito Mariscal Sucr-SDF Louisville Intl

25h 49m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$668LATAM Airlines

Thu, Apr 1 - Mon, Apr 12

6:10 am - 11:23 pmSDF Louisville Intl-BOG Bogotá El Dorado

17h 13m2 stops Chicago O'Hare Intl Dallas/Fort Worth

3:15 pm - 11:10 amBOG Bogotá El Dorado-SDF Louisville Intl

19h 55m2 stops Miami Philadelphia

$788GOL

Thu, Jan 14 - Sun, Jan 24

6:10 am - 11:23 pmSDF Louisville Intl-BOG Bogotá El Dorado

17h 13m2 stops Chicago O'Hare Intl Dallas/Fort Worth

3:15 pm - 11:59 pmBOG Bogotá El Dorado-SDF Louisville Intl

8h 44m1 stop Miami

$821GOL

Thu, Jan 14 - Sun, Jan 24

Cheap last minute flights

Enter your travel dates to find the best prices.

5:15 am - 12:10 amSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

17h 55m2 stops Chicago O'Hare Intl Panama City Tocumen Intl

11:10 am - 9:38 amGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

24h 28m2 stops Panama City Tocumen Intl Chicago O'Hare Intl

$1,319Copa Airlines

Sat, Oct 10 - Tue, Nov 10

5:49 pm - 9:00 amSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

14h 11m1 stop Dallas/Fort Worth

10:35 pm - 4:56 pmGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

20h 21m1 stop Dallas/Fort Worth

$1,414American Airlines

Sun, Oct 11 - Mon, Nov 9

5:49 pm - 9:00 amSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

14h 11m1 stop Dallas/Fort Worth

12:05 am - 3:30 pmGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

17h 25m2 stops Miami Dallas/Fort Worth

$1,418American Airlines

Sun, Oct 11 - Sun, Nov 8

7:25 am - 8:00 amSDF Louisville Intl-EZE Buenos Aires Ministro Pistarini

23h 35m1 stop Houston George Bush Intcntl

9:00 pm - 10:10 pmEZE Buenos Aires Ministro Pistarini-SDF Louisville Intl

26h 10m1 stop Houston George Bush Intcntl

$1,467United Airlines

Fri, Oct 9 - Sun, Oct 11

7:25 am - 8:00 amSDF Louisville Intl-EZE Buenos Aires Ministro Pistarini

23h 35m1 stop Houston George Bush Intcntl

9:00 pm - 9:34 amEZE Buenos Aires Ministro Pistarini-SDF Louisville Intl

37h 34m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,479United Airlines

Fri, Oct 9 - Sun, Oct 11

4:18 pm - 9:00 amSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

15h 42m1 stop Dallas/Fort Worth

11:00 pm - 12:25 amGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

27h 25m2 stops Belém Val De Cans Miami

$1,489GOL

Sat, Oct 10 - Tue, Nov 10

7:55 pm - 8:00 pmSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

23h 05m2 stops Atlanta Hartsfield-Jackson Miami

3:35 am - 10:53 pmGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

21h 18m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,510LATAM Airlines

Sun, Oct 11 - Sun, Nov 8

6:00 am - 5:55 amSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

22h 55m1 stop Miami

10:35 pm - 12:55 pmGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

16h 20m1 stop Dallas/Fort Worth

$1,514American Airlines

Sat, Oct 10 - Tue, Nov 10

12:46 pm - 5:55 amSDF Louisville Intl-GRU Sao Paulo Guarulhos Intl

16h 09m2 stops Chicago O'Hare Intl Miami

12:05 am - 3:45 pmGRU Sao Paulo Guarulhos Intl-SDF Louisville Intl

17h 40m2 stops Miami Charlotte Douglas

$1,554GOL

Sun, Oct 11 - Sun, Nov 8

10:25 am - 8:00 amSDF Louisville Intl-EZE Buenos Aires Ministro Pistarini

20h 35m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

9:00 pm - 9:34 amEZE Buenos Aires Ministro Pistarini-SDF Louisville Intl

37h 34m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,604United Airlines

Fri, Oct 9 - Sun, Oct 11

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GOL flights from Louisville to South America

Our best GOL deals on Louisville to South America flight tickets

GOL

Jan 14

SDF6:10 amLouisville Intl

17h 13m

2 stops

BOG11:23 pmBogotá El Dorado

Jan 24

BOG3:15 pmBogotá El Dorado

19h 55m

2 stops

SDF11:10 amLouisville Intl

$788

GOL

Jan 14

SDF6:10 amLouisville Intl

17h 13m

2 stops

BOG11:23 pmBogotá El Dorado

Jan 24

BOG3:15 pmBogotá El Dorado

8h 44m

1 stop

SDF11:59 pmLouisville Intl

$821

GOL

Dec 7

SDF4:35 pmLouisville Intl

19h 59m

2 stops

BOG12:34 pmBogotá El Dorado

Dec 10

BOG7:50 amBogotá El Dorado

16h 09m

1 stop

SDF11:59 pmLouisville Intl

$823

LATAM Airlines flights from Louisville to South America

Our best LATAM Airlines deals on Louisville to South America flight tickets

LATAM Airlines

Nov 1

SDF7:05 amLouisville Intl

15h 55m

2 stops

UIO11:00 pmQuito Mariscal Sucr

Nov 8

UIO7:05 amQuito Mariscal Sucr

26h 01m

2 stops

SDF9:06 amLouisville Intl

$718

LATAM Airlines

Apr 1

SDF8:20 amLouisville Intl

15h 40m

2 stops

UIO11:00 pmQuito Mariscal Sucr

Apr 12

UIO7:05 amQuito Mariscal Sucr

24h 41m

2 stops

SDF8:46 amLouisville Intl

$734

LATAM Airlines

Nov 2

SDF7:05 amLouisville Intl

13h 25m

2 stops

LIM8:30 pmLima J Chavez Intl

Nov 9

LIM12:10 pmLima J Chavez Intl

12h 00m

1 stop

SDF12:10 amLouisville Intl

$754

momondo Fare Finder

Use the filters below to find and compare flights from Louisville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleCartagena

SDF Louisville Intl - CTG Cartagena Rafael Nunez

SDFCTG

Louisville Intl

Sat 10/31

6:16 pm-3:36 pm

2 stops22h 20m

Cartagena Rafael Nunez

Wed 11/4

2:35 pm-9:38 am

2 stops19h 03m

$573

LouisvilleCartagena

SDF Louisville Intl - CTG Cartagena Rafael Nunez

SDFCTG

Louisville Intl

Sun 10/25

6:00 am-12:35 pm

1 stop7h 35m

Cartagena Rafael Nunez

Sat 10/31

1:35 pm-11:22 am

2 stops20h 47m

$573

Quickest round-trip

LouisvilleCartagena

SDF Louisville Intl - CTG Cartagena Rafael Nunez

SDFCTG

Louisville Intl

Wed 3/3

7:00 am-2:10 pm

1 stop7h 10m

Cartagena Rafael Nunez

Mon 3/8

3:30 pm-12:02 am

1 stop8h 32m

$584

LouisvilleCartagena

SDF Louisville Intl - CTG Cartagena Rafael Nunez

SDFCTG

Louisville Intl

Wed 3/3

7:00 am-2:10 pm

1 stop7h 10m

Cartagena Rafael Nunez

Mon 3/8

3:30 pm-12:02 am

1 stop8h 32m

$585

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Wed 1/13

8:50 am-12:30 am

2 stops15h 40m

Quito Mariscal Sucr

Tue 1/19

1:35 am-4:35 pm

2 stops15h 00m

$662

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Wed 1/13

7:00 am-12:30 am

1 stop17h 30m

Quito Mariscal Sucr

Tue 1/19

1:35 am-6:29 pm

2 stops16h 54m

$662

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Sun 11/15

10:13 am-11:00 pm

2 stops12h 47m

Quito Mariscal Sucr

Sun 11/22

7:05 am-9:06 am

2 stops26h 01m

$668

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Thu 4/1

7:00 am-6:59 pm

1 stop12h 59m

Quito Mariscal Sucr

Mon 4/12

7:05 am-9:54 am

2 stops25h 49m

$668

LouisvilleBogotá

SDF Louisville Intl - BOG Bogotá El Dorado

SDFBOG

Louisville Intl

Thu 1/14

6:10 am-11:23 pm

2 stops17h 13m

Bogotá El Dorado

Sun 1/24

3:15 pm-11:10 am

2 stops19h 55m

$788

LouisvilleBogotá

SDF Louisville Intl - BOG Bogotá El Dorado

SDFBOG

Louisville Intl

Thu 1/14

6:10 am-11:23 pm

2 stops17h 13m

Bogotá El Dorado

Sun 1/24

3:15 pm-11:59 pm

1 stop8h 44m

$821

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Louisville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, June is the cheapest month to fly from Louisville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $669. If you aren’t able to travel during the month of June, then book flights to South America from Louisville during January instead. Flights to South America in January, while not as cheap as those in June, still average around $687.

Can stopping save me money on Louisville to South America flights?

You could potentially save up to 47% on your flight if you consider stops on a Louisville to South America flight.

Cheap Louisville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to South America

Best Price Found	$303
Fastest flight time	9h 35m
Direct flights	None

The best one-way flight to South America from Louisville in the past 72 hours is $303. The best round-trip flight deal from Louisville to South America found on momondo in the last 72 hours is $573.

The fastest flight from Louisville to South America takes 9h 35m

There are no direct flights from Louisville to South America. There are no popular flight routes from Louisville to South America.

Search flight deals

Frequently asked questions about flying from Louisville to South America

When did momondo last update prices for flights from Louisville Intl Airport to South America?
Prices for flights from Louisville Intl Airport to South America were last updated today.
How many operators does momondo search for flights from Louisville Intl Airport to South America?
As of October 2026, there are 4 operators available to choose from for flights from Louisville Intl Airport to South America.
How old do you have to be to fly from Louisville Intl Airport to South America?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Louisville to South America

Compare and see reviews for airlines that fly from Louisville to South America with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $558	Free Cancellation	Rating 7.0 12,126 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $669	Free Cancellation	Rating 7.4 1,975 reviews	Search LATAM Airlines flights
Delta	PriceFrom $755	Free Cancellation	Rating 7.8 8,628 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to South America?

It is quick and easy to find Louisville to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from Louisville to South America with flexible booking policies on momondo?

All flight searches from Louisville to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Louisville to South America?

Once all potential Louisville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Louisville to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.