What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Louisville according to our data. Delta is the first choice among our users, with 43% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 6 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Louisville Intl to South America?

LATAM Airlines, American Airlines, and Delta are the most popular carriers operating from Louisville Intl to South America

When did momondo last update prices for flights from Louisville Intl Airport to South America?

Prices for flights from Louisville Intl Airport to South America were last updated today.

How many operators does momondo search for flights from Louisville Intl Airport to South America?

As of July 2026, there are 3 operators available to choose from for flights from Louisville Intl Airport to South America.

How old do you have to be to fly from Louisville Intl Airport to South America?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$302 Cheap Flights from Louisville to South America in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Louisville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 10:11 pm

SDF

GYE

17h 11m

1 stop

6:00 am - 10:42 pm

GYE

SDF

15h 42m

1 stop

$683American Airlines

Tue, Sep 22 - Wed, Sep 30

8:09 am - 6:59 pm

SDF

UIO

11h 50m

1 stop

12:59 am - 12:20 pm

UIO

SDF

10h 21m

1 stop

$687Delta

Tue, Sep 22 - Mon, Sep 28

7:03 am - 10:11 pm

SDF

GYE

16h 08m

2 stops

6:00 am - 10:42 pm

GYE

SDF

15h 42m

1 stop

$688American Airlines

Tue, Sep 22 - Wed, Sep 30

9:45 am - 6:59 pm

SDF

UIO

10h 14m

1 stop

9:00 am - 8:51 am

UIO

SDF

22h 51m

2 stops

$692Delta

Tue, Sep 22 - Tue, Sep 29

3:24 pm - 5:00 am

SDF

LIM

14h 36m

1 stop

12:00 pm - 10:35 pm

LIM

SDF

10h 35m

1 stop

$702LATAM Airlines

Mon, Oct 26 - Thu, Nov 5

7:30 pm - 5:00 am

SDF

LIM

9h 30m

1 stop

1:30 pm - 11:36 am

LIM

SDF

22h 06m

2 stops

$703LATAM Airlines

Mon, Nov 23 - Mon, Dec 7

7:25 am - 11:25 pm

SDF

UIO

17h 00m

1 stop

7:00 am - 10:15 pm

UIO

SDF

14h 15m

1 stop

$721United Airlines

Sun, Aug 16 - Sun, Aug 30

5:10 am - 11:25 pm

SDF

UIO

19h 15m

2 stops

12:35 am - 11:59 pm

UIO

SDF

22h 24m

2 stops

$726United Airlines

Sun, Aug 16 - Sat, Aug 29

7:10 am - 7:55 am

SDF

GIG

23h 45m

2 stops

5:10 am - 10:18 am

GIG

SDF

30h 08m

2 stops

$1,061Copa Airlines

Sat, Sep 12 - Sat, Oct 3

5:10 am - 12:25 am

SDF

GIG

18h 15m

2 stops

5:10 am - 10:18 am

GIG

SDF

30h 08m

2 stops

$1,199Copa Airlines

Sun, Aug 16 - Sun, Aug 23

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LATAM Airlines flights from Louisville to South America

Our best LATAM Airlines deals on Louisville to South America flight tickets

LATAM Airlines

Oct 26

SDF3:24 pmLouisville Intl

14h 36m

1 stop

LIM5:00 amLima J Chavez Intl

Nov 5

LIM12:00 pmLima J Chavez Intl

10h 35m

1 stop

SDF10:35 pmLouisville Intl

$702

LATAM Airlines

Nov 23

SDF7:30 pmLouisville Intl

9h 30m

1 stop

LIM5:00 amLima J Chavez Intl

Dec 7

LIM1:30 pmLima J Chavez Intl

22h 06m

2 stops

SDF11:36 amLouisville Intl

$703

LATAM Airlines

Nov 23

SDF3:24 pmLouisville Intl

14h 36m

2 stops

LIM6:00 amLima J Chavez Intl

Dec 7

LIM1:30 pmLima J Chavez Intl

22h 06m

2 stops

SDF11:36 amLouisville Intl

$708

Copa Airlines flights from Louisville to South America

Our best Copa Airlines deals on Louisville to South America flight tickets

Copa Airlines

Aug 6

SDF9:00 amLouisville Intl

28h 25m

2 stops

LIM12:25 pmLima J Chavez Intl

Aug 12

LIM4:40 pmLima J Chavez Intl

25h 27m

2 stops

SDF7:07 pmLouisville Intl

$880

Copa Airlines

Aug 5

SDF7:55 pmLouisville Intl

28h 15m

2 stops

LIM11:10 pmLima J Chavez Intl

Aug 12

LIM4:40 pmLima J Chavez Intl

25h 27m

2 stops

SDF7:07 pmLouisville Intl

$882

Copa Airlines

Aug 5

SDF7:55 pmLouisville Intl

28h 15m

2 stops

LIM11:10 pmLima J Chavez Intl

Aug 11

LIM1:20 pmLima J Chavez Intl

19h 18m

2 stops

SDF9:38 amLouisville Intl

$897

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleGuayaquil

SDF - GYE

SDFGYE

Louisville Intl

Tue 9/22

6:00 am-10:11 pm

1 stop17h 11m

Guayaquil Jose Joaquin de Olmedo

Wed 9/30

6:00 am-10:42 pm

1 stop15h 42m

$683

Quickest round-trip

LouisvilleQuito

SDF - UIO

SDFUIO

Louisville Intl

Tue 9/22

8:09 am-6:59 pm

1 stop11h 50m

Quito Mariscal Sucr

Mon 9/28

12:59 am-12:20 pm

1 stop10h 21m

$687

LouisvilleGuayaquil

SDF - GYE

SDFGYE

Louisville Intl

Tue 9/22

7:03 am-10:11 pm

2 stops16h 08m

Guayaquil Jose Joaquin de Olmedo

Wed 9/30

6:00 am-10:42 pm

1 stop15h 42m

$688

LouisvilleQuito

SDF - UIO

SDFUIO

Louisville Intl

Tue 9/22

9:45 am-6:59 pm

1 stop10h 14m

Quito Mariscal Sucr

Tue 9/29

9:00 am-8:51 am

2 stops22h 51m

$692

LouisvilleLima

SDF - LIM

SDFLIM

Louisville Intl

Mon 10/26

3:24 pm-5:00 am

1 stop14h 36m

Lima J Chavez Intl

Thu 11/5

12:00 pm-10:35 pm

1 stop10h 35m

$702

LouisvilleLima

SDF - LIM

SDFLIM

Louisville Intl

Mon 11/23

7:30 pm-5:00 am

1 stop9h 30m

Lima J Chavez Intl

Mon 12/7

1:30 pm-11:36 am

2 stops22h 06m

$703

LouisvilleQuito

SDF - UIO

SDFUIO

Louisville Intl

Sun 8/16

7:25 am-11:25 pm

1 stop17h 00m

Quito Mariscal Sucr

Sun 8/30

7:00 am-10:15 pm

1 stop14h 15m

$721

LouisvilleQuito

SDF - UIO

SDFUIO

Louisville Intl

Sun 8/16

5:10 am-11:25 pm

2 stops19h 15m

Quito Mariscal Sucr

Sat 8/29

12:35 am-11:59 pm

2 stops22h 24m

$726

LouisvilleRio de Janeiro

SDF - GIG

SDFGIG

Louisville Intl

Sat 9/12

7:10 am-7:55 am

2 stops23h 45m

Rio de Janeiro–Galeão Intl

Sat 10/3

5:10 am-10:18 am

2 stops30h 08m

$1,061

LouisvilleRio de Janeiro

SDF - GIG

SDFGIG

Louisville Intl

Sun 8/16

5:10 am-12:25 am

2 stops18h 15m

Rio de Janeiro–Galeão Intl

Sun 8/23

5:10 am-10:18 am

2 stops30h 08m

$1,199

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Louisville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Louisville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $254. If you aren’t able to travel during the month of September, then book flights to South America from Louisville during December instead. Flights to South America in December, while not as cheap as those in September, still average around $343.

Can stopping save me money on Louisville to South America flights?

You could potentially save up to 3% on your flight if you consider stops on a Louisville to South America flight.

Cheap Louisville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to South America

Fastest flight time	9h 27m
Direct flights	None

The fastest flight from Louisville to South America takes 9h 27m

There are no direct flights from Louisville to South America. There are no popular flight routes from Louisville to South America.

Search flight deals

Frequently asked questions about flying from Louisville to South America

When did momondo last update prices for flights from Louisville Intl Airport to South America?
Prices for flights from Louisville Intl Airport to South America were last updated today.
How many operators does momondo search for flights from Louisville Intl Airport to South America?
As of July 2026, there are 3 operators available to choose from for flights from Louisville Intl Airport to South America.
How old do you have to be to fly from Louisville Intl Airport to South America?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Louisville to South America

Compare and see reviews for airlines that fly from Louisville to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $394	Free Cancellation	Rating 7.8 8,452 reviews	Search Delta flights
American Airlines	PriceFrom $528	Free Cancellation	Rating 7.1 11,781 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $541	Free Cancellation	Rating 7.4 1,949 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to South America?

It is quick and easy to find Louisville to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from Louisville to South America with flexible booking policies on momondo?

All flight searches from Louisville to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Louisville to South America?

Once all potential Louisville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Louisville to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.