What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Louisville according to our data. Delta is the first choice among our users, with 39% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 6 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Louisville Intl to South America?

American Airlines, LATAM Airlines, and United Airlines are the most popular carriers operating from Louisville Intl to South America

When did momondo last update prices for flights from Louisville Intl Airport to South America?

Prices for flights from Louisville Intl Airport to South America were last updated today.

How many operators does momondo search for flights from Louisville Intl Airport to South America?

As of August 2026, there are 3 operators available to choose from for flights from Louisville Intl Airport to South America.

How old do you have to be to fly from Louisville Intl Airport to South America?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$301 Cheap Flights from Louisville to South America in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Louisville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:05 am - 8:00 pmSDF Louisville Intl-BAQ Barranquilla E Cortissoz

12h 55m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

7:10 am - 10:21 amBAQ Barranquilla E Cortissoz-SDF Louisville Intl

27h 11m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$647LATAM Airlines

Sat, Oct 31 - Wed, Nov 4

6:00 am - 1:29 pmSDF Louisville Intl-GYE Guayaquil Jose Joaquin de Olmedo

8h 29m1 stop Miami

6:00 am - 11:45 pmGYE Guayaquil Jose Joaquin de Olmedo-SDF Louisville Intl

16h 45m1 stop Miami

$653American Airlines

Thu, Oct 15 - Sun, Oct 25

8:18 pm - 1:29 pmSDF Louisville Intl-GYE Guayaquil Jose Joaquin de Olmedo

18h 11m2 stops Charlotte Douglas Miami

2:29 pm - 12:10 pmGYE Guayaquil Jose Joaquin de Olmedo-SDF Louisville Intl

20h 41m2 stops Miami Chicago O'Hare Intl

$656American Airlines

Thu, Oct 15 - Sun, Oct 25

8:18 pm - 1:29 pmSDF Louisville Intl-GYE Guayaquil Jose Joaquin de Olmedo

18h 11m2 stops Charlotte Douglas Miami

6:00 am - 11:45 pmGYE Guayaquil Jose Joaquin de Olmedo-SDF Louisville Intl

16h 45m1 stop Miami

$656American Airlines

Thu, Oct 15 - Sun, Oct 25

7:00 am - 7:30 pmSDF Louisville Intl-BOG Bogotá El Dorado

12h 30m1 stop Atlanta Hartsfield-Jackson

9:00 am - 7:01 pmBOG Bogotá El Dorado-SDF Louisville Intl

10h 01m1 stop Atlanta Hartsfield-Jackson

$679Delta

Thu, Feb 11 - Sat, Feb 27

6:00 am - 7:30 pmSDF Louisville Intl-BOG Bogotá El Dorado

13h 30m1 stop Atlanta Hartsfield-Jackson

9:00 am - 8:51 pmBOG Bogotá El Dorado-SDF Louisville Intl

11h 51m2 stops Orlando Atlanta Hartsfield-Jackson

$684Delta

Thu, Feb 11 - Fri, Feb 26

3:35 pm - 11:25 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

8h 50m1 stop Houston George Bush Intcntl

12:35 am - 7:55 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

18h 20m1 stop Houston George Bush Intcntl

$687United Airlines

Tue, Sep 22 - Mon, Sep 28

7:25 am - 11:25 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

17h 00m1 stop Houston George Bush Intcntl

12:35 am - 1:09 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

11h 34m1 stop Houston George Bush Intcntl

$687United Airlines

Tue, Sep 22 - Mon, Sep 28

7:05 am - 6:59 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

12h 54m1 stop Atlanta Hartsfield-Jackson

9:00 am - 11:59 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

13h 59m2 stops Miami Atlanta Hartsfield-Jackson

$689LATAM Airlines

Tue, Sep 22 - Tue, Sep 29

1:15 pm - 11:00 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

10h 45m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

9:00 am - 11:59 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

13h 59m2 stops Miami Atlanta Hartsfield-Jackson

$689LATAM Airlines

Tue, Sep 22 - Tue, Sep 29

Cheap last minute flights

Enter your travel dates to find the best prices.

10:23 am - 11:32 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

14h 09m2 stops Chicago O'Hare Intl Panama City Tocumen Intl

3:09 pm - 9:38 amUIO Quito Mariscal Sucr-SDF Louisville Intl

17h 29m2 stops Panama City Tocumen Intl Chicago O'Hare Intl

$886Copa Airlines

Sat, Aug 22 - Sat, Sep 5

9:00 am - 12:33 amSDF Louisville Intl-UIO Quito Mariscal Sucr

16h 33m2 stops Chicago O'Hare Intl Panama City Tocumen Intl

1:29 am - 7:07 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

16h 38m2 stops Panama City Tocumen Intl Chicago O'Hare Intl

$910Copa Airlines

Fri, Aug 21 - Fri, Sep 4

9:00 am - 12:33 amSDF Louisville Intl-UIO Quito Mariscal Sucr

16h 33m2 stops Chicago O'Hare Intl Panama City Tocumen Intl

3:07 am - 8:36 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

16h 29m2 stops Panama City Tocumen Intl Chicago O'Hare Intl

$932Copa Airlines

Fri, Aug 21 - Sat, Sep 5

7:05 am - 7:05 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

13h 00m2 stops Atlanta Hartsfield-Jackson Miami

6:35 pm - 12:24 amUIO Quito Mariscal Sucr-SDF Louisville Intl

28h 49m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,011LATAM Airlines

Fri, Aug 21 - Tue, Sep 1

9:52 am - 4:42 amSDF Louisville Intl-UIO Quito Mariscal Sucr

19h 50m2 stops Atlanta Hartsfield-Jackson Miami

12:59 am - 7:30 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

17h 31m1 stop Atlanta Hartsfield-Jackson

$1,019Delta

Mon, Aug 24 - Sun, Sep 6

8:05 am - 4:42 amSDF Louisville Intl-UIO Quito Mariscal Sucr

21h 37m2 stops Atlanta Hartsfield-Jackson Miami

12:59 am - 5:11 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

15h 12m1 stop Atlanta Hartsfield-Jackson

$1,019Delta

Mon, Aug 24 - Mon, Sep 7

9:45 am - 11:25 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

14h 40m1 stop Houston George Bush Intcntl

12:35 am - 7:59 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

18h 24m1 stop Houston George Bush Intcntl

$1,019United Airlines

Mon, Aug 24 - Fri, Sep 4

3:35 pm - 11:25 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

8h 50m1 stop Houston George Bush Intcntl

7:00 am - 10:15 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

14h 15m1 stop Houston George Bush Intcntl

$1,019United Airlines

Mon, Aug 24 - Sun, Sep 6

7:05 am - 6:59 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

12h 54m1 stop Atlanta Hartsfield-Jackson

6:35 pm - 11:59 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

28h 24m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,039LATAM Airlines

Sat, Aug 22 - Tue, Sep 8

7:05 am - 6:59 pmSDF Louisville Intl-UIO Quito Mariscal Sucr

12h 54m1 stop Atlanta Hartsfield-Jackson

6:35 pm - 11:59 pmUIO Quito Mariscal Sucr-SDF Louisville Intl

28h 24m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,039LATAM Airlines

Sun, Aug 23 - Tue, Sep 8

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Delta flights from Louisville to South America

Our best Delta deals on Louisville to South America flight tickets

Delta

Feb 11

SDF7:00 amLouisville Intl

12h 30m

1 stop

BOG7:30 pmBogotá El Dorado

Feb 26

BOG3:55 pmBogotá El Dorado

17h 59m

1 stop

SDF9:54 amLouisville Intl

$679

Delta

Feb 11

SDF6:00 amLouisville Intl

13h 30m

1 stop

BOG7:30 pmBogotá El Dorado

Feb 26

BOG9:00 amBogotá El Dorado

11h 51m

2 stops

SDF8:51 pmLouisville Intl

$684

Delta

Sep 14

SDF6:00 amLouisville Intl

8h 40m

1 stop

BOG1:40 pmBogotá El Dorado

Sep 22

BOG9:00 amBogotá El Dorado

13h 59m

1 stop

SDF11:59 pmLouisville Intl

$685

LATAM Airlines flights from Louisville to South America

Our best LATAM Airlines deals on Louisville to South America flight tickets

LATAM Airlines

Oct 31

SDF8:05 amLouisville Intl

12h 55m

2 stops

BAQ8:00 pmBarranquilla E Cortissoz

Nov 4

BAQ7:10 amBarranquilla E Cortissoz

27h 11m

2 stops

SDF10:21 amLouisville Intl

$647

LATAM Airlines

Aug 25

SDF11:17 amLouisville Intl

8h 58m

1 stop

BOG7:15 pmBogotá El Dorado

Sep 23

BOG2:55 pmBogotá El Dorado

8h 04m

1 stop

SDF11:59 pmLouisville Intl

$685

LATAM Airlines

Sep 22

SDF7:05 amLouisville Intl

12h 54m

1 stop

UIO6:59 pmQuito Mariscal Sucr

Sep 29

UIO9:00 amQuito Mariscal Sucr

13h 59m

2 stops

SDF11:59 pmLouisville Intl

$689

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleBarranquilla

SDF Louisville Intl - BAQ Barranquilla E Cortissoz

SDFBAQ

Louisville Intl

Sat 10/31

8:05 am-8:00 pm

2 stops12h 55m

Barranquilla E Cortissoz

Wed 11/4

7:10 am-10:21 am

2 stops27h 11m

$647

LouisvilleGuayaquil

SDF Louisville Intl - GYE Guayaquil Jose Joaquin de Olmedo

SDFGYE

Louisville Intl

Thu 10/15

6:00 am-1:29 pm

1 stop8h 29m

Guayaquil Jose Joaquin de Olmedo

Sun 10/25

6:00 am-11:45 pm

1 stop16h 45m

$653

LouisvilleGuayaquil

SDF Louisville Intl - GYE Guayaquil Jose Joaquin de Olmedo

SDFGYE

Louisville Intl

Thu 10/15

8:18 pm-1:29 pm

2 stops18h 11m

Guayaquil Jose Joaquin de Olmedo

Sun 10/25

2:29 pm-12:10 pm

2 stops20h 41m

$656

LouisvilleGuayaquil

SDF Louisville Intl - GYE Guayaquil Jose Joaquin de Olmedo

SDFGYE

Louisville Intl

Thu 10/15

8:18 pm-1:29 pm

2 stops18h 11m

Guayaquil Jose Joaquin de Olmedo

Sun 10/25

6:00 am-11:45 pm

1 stop16h 45m

$656

Quickest round-trip

LouisvilleBogotá

SDF Louisville Intl - BOG Bogotá El Dorado

SDFBOG

Louisville Intl

Thu 2/11

7:00 am-7:30 pm

1 stop12h 30m

Bogotá El Dorado

Sat 2/27

9:00 am-7:01 pm

1 stop10h 01m

$679

LouisvilleBogotá

SDF Louisville Intl - BOG Bogotá El Dorado

SDFBOG

Louisville Intl

Thu 2/11

6:00 am-7:30 pm

1 stop13h 30m

Bogotá El Dorado

Fri 2/26

9:00 am-8:51 pm

2 stops11h 51m

$684

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Tue 9/22

3:35 pm-11:25 pm

1 stop8h 50m

Quito Mariscal Sucr

Mon 9/28

12:35 am-7:55 pm

1 stop18h 20m

$687

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Tue 9/22

7:25 am-11:25 pm

1 stop17h 00m

Quito Mariscal Sucr

Mon 9/28

12:35 am-1:09 pm

1 stop11h 34m

$687

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Tue 9/22

7:05 am-6:59 pm

1 stop12h 54m

Quito Mariscal Sucr

Tue 9/29

9:00 am-11:59 pm

2 stops13h 59m

$689

LouisvilleQuito

SDF Louisville Intl - UIO Quito Mariscal Sucr

SDFUIO

Louisville Intl

Tue 9/22

1:15 pm-11:00 pm

2 stops10h 45m

Quito Mariscal Sucr

Tue 9/29

9:00 am-11:59 pm

2 stops13h 59m

$689

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Louisville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Louisville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $685. If you aren’t able to travel during the month of September, then book flights to South America from Louisville during January instead. Flights to South America in January, while not as cheap as those in September, still average around $687.

Can stopping save me money on Louisville to South America flights?

You could potentially save up to 31% on your flight if you consider stops on a Louisville to South America flight.

Cheap Louisville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to South America

Best Price Found	$301
Fastest flight time	7h 25m
Direct flights	None

The best one-way flight to South America from Louisville in the past 72 hours is $301. The best round-trip flight deal from Louisville to South America found on momondo in the last 72 hours is $647.

The fastest flight from Louisville to South America takes 7h 25m

There are no direct flights from Louisville to South America. There are no popular flight routes from Louisville to South America.

Search flight deals

Frequently asked questions about flying from Louisville to South America

When did momondo last update prices for flights from Louisville Intl Airport to South America?
Prices for flights from Louisville Intl Airport to South America were last updated today.
How many operators does momondo search for flights from Louisville Intl Airport to South America?
As of August 2026, there are 3 operators available to choose from for flights from Louisville Intl Airport to South America.
How old do you have to be to fly from Louisville Intl Airport to South America?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Louisville to South America

Compare and see reviews for airlines that fly from Louisville to South America with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $558	Free Cancellation	Rating 7.1 11,965 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $669	Free Cancellation	Rating 7.4 1,989 reviews	Search LATAM Airlines flights
Delta	PriceFrom $755	Free Cancellation	Rating 7.8 8,500 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to South America?

It is quick and easy to find Louisville to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from Louisville to South America with flexible booking policies on momondo?

All flight searches from Louisville to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Louisville to South America?

Once all potential Louisville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Louisville to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.