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Cheap flights from Louisville to Des Moines from $156

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Des Moines departing on 5/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:26 am - 5:45 pm
SDF
-
DSM
7h 19m
1 stop
Delta Logo
2:33 pm - 7:50 pm
DSM
-
SDF
4h 17m
1 stop
$291Delta
Sat, May 2 - Sat, May 9
Southwest Logo
8:55 am - 11:25 am
SDF
-
DSM
3h 30m
1 stop
Southwest Logo
5:35 am - 10:05 am
DSM
-
SDF
3h 30m
1 stop
$299Southwest
Wed, May 20 - Sat, May 23
Southwest Logo
8:10 pm - 11:05 pm
SDF
-
DSM
3h 55m
1 stop
Southwest Logo
4:20 pm - 9:00 pm
DSM
-
SDF
3h 40m
1 stop
$311Southwest
Thu, May 21 - Thu, May 28
Southwest Logo
1:45 pm - 8:55 pm
SDF
-
DSM
8h 10m
1 stop
Southwest Logo
5:35 am - 11:20 pm
DSM
-
SDF
16h 45m
2 stops
$327Southwest
Sat, May 2 - Sat, May 9
American Airlines Logo
6:07 am - 11:26 am
SDF
-
DSM
6h 19m
1 stop
American Airlines Logo
8:43 am - 6:49 pm
DSM
-
SDF
9h 06m
2 stops
$328American Airlines
Wed, May 20 - Sat, May 23
Delta Logo
6:05 am - 10:16 am
SDF
-
DSM
5h 11m
1 stop
Delta Logo
6:43 am - 11:57 am
DSM
-
SDF
4h 14m
1 stop
$329Delta
Thu, May 28 - Sun, Jun 7
Delta Logo
7:08 am - 1:37 pm
SDF
-
DSM
7h 29m
1 stop
Delta Logo
6:43 am - 11:57 am
DSM
-
SDF
4h 14m
1 stop
$347Delta
Fri, May 29 - Sun, Jun 7
American Airlines Logo
8:08 pm - 12:17 am
SDF
-
DSM
5h 09m
1 stop
American Airlines Logo
5:00 am - 2:52 pm
DSM
-
SDF
8h 52m
2 stops
$352American Airlines
Fri, May 22 - Sun, May 24
Southwest Logo
8:10 pm - 11:05 pm
SDF
-
DSM
3h 55m
1 stop
Southwest Logo
5:25 am - 4:50 pm
DSM
-
SDF
10h 25m
2 stops
$360Southwest
Thu, May 21 - Thu, May 28
American Airlines Logo
7:01 pm - 11:49 pm
SDF
-
DSM
5h 48m
1 stop
American Airlines Logo
8:56 am - 4:05 pm
DSM
-
SDF
6h 09m
1 stop
$373American Airlines
Mon, May 4 - Tue, May 5

Delta flights from Louisville to Des Moines

Our best Delta deals on Louisville to Des Moines flight tickets
Delta
May 2
SDF11:26 amLouisville Intl
7h 19m
1 stop
DSM5:45 pmDes Moines
May 9
DSM2:33 pmDes Moines
4h 17m
1 stop
SDF7:50 pmLouisville Intl
$291
Delta
May 28
SDF6:05 amLouisville Intl
5h 11m
1 stop
DSM10:16 amDes Moines
Jun 7
DSM6:43 amDes Moines
4h 14m
1 stop
SDF11:57 amLouisville Intl
$329
Delta
May 29
SDF7:08 amLouisville Intl
7h 29m
1 stop
DSM1:37 pmDes Moines
Jun 7
DSM6:43 amDes Moines
4h 14m
1 stop
SDF11:57 amLouisville Intl
$347

American Airlines flights from Louisville to Des Moines

Our best American Airlines deals on Louisville to Des Moines flight tickets
American Airlines
May 20
SDF6:07 amLouisville Intl
6h 19m
1 stop
DSM11:26 amDes Moines
May 23
DSM8:43 amDes Moines
9h 06m
2 stops
SDF6:49 pmLouisville Intl
$328
American Airlines
May 22
SDF8:08 pmLouisville Intl
5h 09m
1 stop
DSM12:17 amDes Moines
May 24
DSM5:00 amDes Moines
8h 52m
2 stops
SDF2:52 pmLouisville Intl
$352
American Airlines
May 4
SDF7:01 pmLouisville Intl
5h 48m
1 stop
DSM11:49 pmDes Moines
May 5
DSM8:56 amDes Moines
6h 09m
1 stop
SDF4:05 pmLouisville Intl
$373

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 14, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 5/2

11:26 am-5:45 pm

1 stop7h 19m

Des Moines

Sat 5/9

2:33 pm-7:50 pm

1 stop4h 17m

$291
Quickest round-trip

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 5/20

8:55 am-11:25 am

1 stop3h 30m

Des Moines

Sat 5/23

5:35 am-10:05 am

1 stop3h 30m

$299

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 5/21

8:10 pm-11:05 pm

1 stop3h 55m

Des Moines

Thu 5/28

4:20 pm-9:00 pm

1 stop3h 40m

$311

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 5/2

1:45 pm-8:55 pm

1 stop8h 10m

Des Moines

Sat 5/9

5:35 am-11:20 pm

2 stops16h 45m

$327

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 5/20

6:07 am-11:26 am

1 stop6h 19m

Des Moines

Sat 5/23

8:43 am-6:49 pm

2 stops9h 06m

$328

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 5/28

6:05 am-10:16 am

1 stop5h 11m

Des Moines

Sun 6/7

6:43 am-11:57 am

1 stop4h 14m

$329

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/29

7:08 am-1:37 pm

1 stop7h 29m

Des Moines

Sun 6/7

6:43 am-11:57 am

1 stop4h 14m

$347

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/22

8:08 pm-12:17 am

1 stop5h 09m

Des Moines

Sun 5/24

5:00 am-2:52 pm

2 stops8h 52m

$352

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 5/21

8:10 pm-11:05 pm

1 stop3h 55m

Des Moines

Thu 5/28

5:25 am-4:50 pm

2 stops10h 25m

$360

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 5/4

7:01 pm-11:49 pm

1 stop5h 48m

Des Moines

Tue 5/5

8:56 am-4:05 pm

1 stop6h 09m

$373

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Louisville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Louisville to Des Moines flight prices changed over time?

When to book flights from Louisville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Des Moines (SDF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Des Moines

Fastest flight time

4h 44m

Direct flights

None
The fastest flight from Louisville to Des Moines takes 4h 44m
There are no direct flights from Louisville to Des Moines. There are no popular flight routes from Louisville to Des Moines.
Search flight deals

Frequently asked questions about flying from Louisville to Des Moines

  • How far is Louisville Intl to Des Moines by plane?

    Louisville Intl and Des Moines are 476.1 mi apart from one another. In terms of flight time, this usually takes a little over 4h 44m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Des Moines Airport?

    Prices for flights from Louisville Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Des Moines?

Best airlines flying from Louisville to Des Moines

Compare and see reviews for airlines that fly from Louisville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $105Free CancellationRating
7.9
8,406 reviews
Search Delta flights
American AirlinesPriceFrom $158Free CancellationRating
7.1
11,573 reviews
Search American Airlines flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,581 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Louisville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Louisville to Des Moines?

Once all potential Louisville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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