Cheap flights from Louisville to Des Moines from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Des Moines departing on 1/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:35 am - 10:55 am
SDF
-
DSM
6h 20m1 stop
United Airlines Logo
3:35 pm - 10:30 pm
DSM
-
SDF
5h 55m1 stop
$251United Airlines
Wed, Jan 28 - Sat, Jan 31
American Airlines Logo
1:32 pm - 4:24 pm
SDF
-
DSM
3h 52m1 stop
American Airlines Logo
11:42 am - 9:16 pm
DSM
-
SDF
8h 34m2 stops
$256American Airlines
Wed, Jan 28 - Sat, Jan 31
American Airlines Logo
7:00 am - 3:45 pm
SDF
-
DSM
9h 45m2 stops
American Airlines Logo
7:10 am - 6:30 pm
DSM
-
SDF
10h 20m2 stops
$261American Airlines
Wed, Jan 28 - Sat, Jan 31
United Airlines Logo
5:54 pm - 9:41 pm
SDF
-
DSM
4h 47m1 stop
United Airlines Logo
3:24 pm - 8:09 pm
DSM
-
SDF
3h 45m1 stop
$289United Airlines
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
6:32 am - 9:39 am
SDF
-
DSM
4h 07m1 stop
American Airlines Logo
2:02 pm - 9:55 pm
DSM
-
SDF
6h 53m1 stop
$302American Airlines
Mon, Mar 2 - Thu, Mar 5
Southwest Logo
1:30 pm - 9:20 pm
SDF
-
DSM
8h 50m1 stop
Southwest Logo
5:35 am - 3:50 pm
DSM
-
SDF
9h 15m2 stops
$339Southwest
Mon, Mar 2 - Thu, Mar 5
American Airlines Logo
8:58 am - 12:14 pm
SDF
-
DSM
4h 16m1 stop
American Airlines Logo
1:46 pm - 7:43 pm
DSM
-
SDF
4h 57m1 stop
$347American Airlines
Fri, May 15 - Sat, May 16
American Airlines Logo
8:58 am - 12:14 pm
SDF
-
DSM
4h 16m1 stop
American Airlines Logo
2:38 pm - 12:14 am
DSM
-
SDF
8h 36m2 stops
$352American Airlines
Fri, May 15 - Sat, May 16
Southwest Logo
11:40 am - 10:15 pm
SDF
-
DSM
11h 35m2 stops
Southwest Logo
5:35 am - 3:50 pm
DSM
-
SDF
9h 15m2 stops
$358Southwest
Mon, Mar 2 - Thu, Mar 5
Southwest Logo
8:10 pm - 11:05 pm
SDF
-
DSM
3h 55m1 stop
Southwest Logo
5:20 am - 9:45 am
DSM
-
SDF
3h 25m1 stop
$397Southwest
Fri, May 15 - Sun, May 17

United Airlines flights from Louisville to Des Moines

Our best United Airlines deals on Louisville to Des Moines flight tickets
United Airlines
Jan 28
SDF5:35 amLouisville Intl
6h 20m
1 stop
DSM10:55 amDes Moines
Jan 31
DSM3:35 pmDes Moines
5h 55m
1 stop
SDF10:30 pmLouisville Intl
United Airlines
Feb 14
SDF5:35 amLouisville Intl
6h 18m
1 stop
DSM10:53 amDes Moines
Feb 18
DSM3:24 pmDes Moines
3h 45m
1 stop
SDF8:09 pmLouisville Intl
United Airlines
May 15
SDF7:20 pmLouisville Intl
4h 32m
1 stop
DSM10:52 pmDes Moines
May 16
DSM6:15 amDes Moines
12h 26m
2 stops
SDF7:41 pmLouisville Intl

American Airlines flights from Louisville to Des Moines

Our best American Airlines deals on Louisville to Des Moines flight tickets
American Airlines
Jan 28
SDF7:40 amLouisville Intl
8h 35m
1 stop
DSM3:15 pmDes Moines
Jan 31
DSM7:10 amDes Moines
7h 42m
2 stops
SDF3:52 pmLouisville Intl
American Airlines
Jan 28
SDF7:00 amLouisville Intl
10h 24m
2 stops
DSM4:24 pmDes Moines
Jan 31
DSM11:42 amDes Moines
8h 34m
2 stops
SDF9:16 pmLouisville Intl
American Airlines
Mar 2
SDF6:32 amLouisville Intl
4h 07m
1 stop
DSM9:39 amDes Moines
Mar 5
DSM2:02 pmDes Moines
6h 53m
1 stop
SDF9:55 pmLouisville Intl

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 1/28

5:35 am-10:55 am

1 stop6h 20m

Des Moines

Sat 1/31

3:35 pm-10:30 pm

1 stop5h 55m

$251

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 1/28

1:32 pm-4:24 pm

1 stop3h 52m

Des Moines

Sat 1/31

11:42 am-9:16 pm

2 stops8h 34m

$256

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 1/28

7:00 am-3:45 pm

2 stops9h 45m

Des Moines

Sat 1/31

7:10 am-6:30 pm

2 stops10h 20m

$261

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 2/14

5:54 pm-9:41 pm

1 stop4h 47m

Des Moines

Wed 2/18

3:24 pm-8:09 pm

1 stop3h 45m

$289

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 3/2

6:32 am-9:39 am

1 stop4h 07m

Des Moines

Thu 3/5

2:02 pm-9:55 pm

1 stop6h 53m

$302

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 3/2

1:30 pm-9:20 pm

1 stop8h 50m

Des Moines

Thu 3/5

5:35 am-3:50 pm

2 stops9h 15m

$339

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/15

8:58 am-12:14 pm

1 stop4h 16m

Des Moines

Sat 5/16

1:46 pm-7:43 pm

1 stop4h 57m

$347

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/15

8:58 am-12:14 pm

1 stop4h 16m

Des Moines

Sat 5/16

2:38 pm-12:14 am

2 stops8h 36m

$352

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 3/2

11:40 am-10:15 pm

2 stops11h 35m

Des Moines

Thu 3/5

5:35 am-3:50 pm

2 stops9h 15m

$358

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/15

8:10 pm-11:05 pm

1 stop3h 55m

Des Moines

Sun 5/17

5:20 am-9:45 am

1 stop3h 25m

$397

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Louisville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Louisville Intl to Des Moines?

Delta, American Airlines, and Allegiant Air are the most popular carriers operating from Louisville Intl to Des Moines

What airlines fly to Des Moines?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Des Moines from Louisville according to our data. American Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Louisville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Des Moines (SDF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Des Moines

Fastest flight time

4h 29m

Direct flights

None
The fastest flight from Louisville to Des Moines takes 4h 29m
There are no direct flights from Louisville to Des Moines. There are no popular flight routes from Louisville to Des Moines.
  • How far is Louisville Intl to Des Moines by plane?

    Louisville Intl and Des Moines are 476.1 mi apart from one another. In terms of flight time, this usually takes a little over 4h 29m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Des Moines Airport?

    Prices for flights from Louisville Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Des Moines?

Best airlines flying from Louisville to Des Moines

Compare and see reviews for airlines that fly from Louisville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $105Free CancellationRating
7.9
8,019 reviews
Search Delta flights
American AirlinesPriceFrom $196Free CancellationRating
7.2
11,072 reviews
Search American Airlines flights
United AirlinesPriceFrom $223Free CancellationRating
7.4
9,113 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Louisville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Louisville to Des Moines?

Once all potential Louisville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
Tue 1/27
Tue 2/3

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