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Cheap flights from Louisville to Des Moines from $297

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Des Moines departing on 2/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Des Moines

Cheap round-trip flights

Delta Logo
6:36 am - 10:22 amSDF-DSM
4h 46m1 stop
Delta Logo
5:15 pm - 11:56 pmDSM-SDF
5h 41m1 stop
$297Delta
Find Deal
Thu, Feb 19 - Mon, Feb 23
American Airlines Logo
6:57 am - 2:26 pmSDF-DSM
8h 29m2 stops
American Airlines Logo
4:27 pm - 9:08 pmDSM-SDF
3h 41m1 stop
$321American Airlines
Find Deal
Thu, Feb 19 - Mon, Feb 23
American Airlines Logo
8:02 am - 2:26 pmSDF-DSM
7h 24m2 stops
American Airlines Logo
4:27 pm - 12:39 amDSM-SDF
7h 12m2 stops
$326American Airlines
Find Deal
Thu, Feb 19 - Mon, Feb 23
American Airlines Logo
3:01 pm - 9:40 pmSDF-DSM
7h 39m1 stop
American Airlines Logo
8:00 am - 4:30 pmDSM-SDF
7h 30m1 stop
$387American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
7:00 am - 9:46 amSDF-DSM
3h 46m1 stop
American Airlines Logo
7:08 am - 4:30 pmDSM-SDF
8h 22m2 stops
$392American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4
American Airlines Logo
8:00 am - 3:33 pmSDF-DSM
8h 33m2 stops
American Airlines Logo
7:08 am - 4:30 pmDSM-SDF
8h 22m2 stops
$397American Airlines
Find Deal
Tue, Sep 30 - Sat, Oct 4

American Airlines flights from Louisville to Des Moines

Our best American Airlines deals on Louisville to Des Moines flight tickets
American Airlines
Feb 19
SDF6:57 amLouisville Intl
8h 29m
2 stops
DSM2:26 pmDes Moines
Feb 23
DSM4:27 pmDes Moines
3h 41m
1 stop
SDF9:08 pmLouisville Intl
$321
Find similar
American Airlines
Feb 19
SDF8:02 amLouisville Intl
7h 24m
2 stops
DSM2:26 pmDes Moines
Feb 23
DSM4:27 pmDes Moines
7h 12m
2 stops
SDF12:39 amLouisville Intl
$326
Find similar
American Airlines
Sep 30
SDF3:01 pmLouisville Intl
7h 39m
1 stop
DSM9:40 pmDes Moines
Oct 4
DSM8:00 amDes Moines
7h 30m
1 stop
SDF4:30 pmLouisville Intl
$387
Find similar

Southwest flights from Louisville to Des Moines

Our best Southwest deals on Louisville to Des Moines flight tickets
Southwest
Sep 19
SDF6:25 amLouisville Intl
5h 40m
2 stops
DSM11:05 amDes Moines
Sep 21
DSM6:10 amDes Moines
9h 35m
2 stops
SDF4:45 pmLouisville Intl
$537
Find similar
Southwest
Sep 19
SDF6:25 amLouisville Intl
5h 40m
2 stops
DSM11:05 amDes Moines
Sep 21
DSM4:15 pmDes Moines
8h 40m
1 stop
SDF1:55 amLouisville Intl
$581
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 2/19

6:36 am-10:22 am

1 stop4h 46m

Des Moines

Mon 2/23

5:15 pm-11:56 pm

1 stop5h 41m

$297

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 2/19

6:57 am-2:26 pm

2 stops8h 29m

Des Moines

Mon 2/23

4:27 pm-9:08 pm

1 stop3h 41m

$321

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 2/19

8:02 am-2:26 pm

2 stops7h 24m

Des Moines

Mon 2/23

4:27 pm-12:39 am

2 stops7h 12m

$326

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 9/30

3:01 pm-9:40 pm

1 stop7h 39m

Des Moines

Sat 10/4

8:00 am-4:30 pm

1 stop7h 30m

$387

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 9/30

7:00 am-9:46 am

1 stop3h 46m

Des Moines

Sat 10/4

7:08 am-4:30 pm

2 stops8h 22m

$392

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 9/30

8:00 am-3:33 pm

2 stops8h 33m

Des Moines

Sat 10/4

7:08 am-4:30 pm

2 stops8h 22m

$397

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Louisville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Louisville to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $286. Flights from Louisville to Des Moines on a Wednesday will generally be more expensive and average around $417. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Louisville to Des Moines in the afternoon for as low as $365. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $437. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have Louisville to Des Moines flight prices changed over time?

When to book flights from Louisville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Des Moines (SDF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Des Moines

Direct flights

None
There are no direct flights from Louisville to Des Moines. There are no popular flight routes from Louisville to Des Moines.
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  • How far is Louisville Intl to Des Moines by plane?

    Louisville Intl and Des Moines are 476.1 mi apart from one another. In terms of flight time, this usually takes a little over 3h 46m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Des Moines Airport?

    Prices for flights from Louisville Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Des Moines?

Best airlines flying from Louisville to Des Moines

Compare and see reviews for airlines that fly from Louisville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $105Free CancellationRating
7.9
7,957 reviews
Search Delta flights
American AirlinesPriceFrom $196Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $246Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Louisville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Louisville to Des Moines?

Once all potential Louisville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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