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Cheap flights from Louisville to Des Moines from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Des Moines departing on 9/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Des Moines

Cheap round-trip flights

Delta Logo
7:10 am - 1:20 pmSDF-DSM
7h 10m1 stop
Delta Logo
6:00 am - 1:42 pmDSM-SDF
6h 42m1 stop
$197Delta
Find Deal
Wed, Sep 17 - Tue, Sep 23
American Airlines Logo
1:16 pm - 4:49 pmSDF-DSM
4h 33m1 stop
American Airlines Logo
7:03 am - 4:48 pmDSM-SDF
8h 45m2 stops
$202American Airlines
Find Deal
Wed, Sep 17 - Tue, Sep 23
American Airlines Logo
1:16 pm - 4:49 pmSDF-DSM
4h 33m1 stop
American Airlines Logo
7:08 am - 2:07 pmDSM-SDF
5h 59m1 stop
$208American Airlines
Find Deal
Wed, Sep 24 - Fri, Sep 26
American Airlines Logo
7:09 pm - 11:06 pmSDF-DSM
4h 57m1 stop
American Airlines Logo
5:11 am - 11:44 amDSM-SDF
5h 33m1 stop
$219American Airlines
Find Deal
Fri, Sep 12 - Sun, Sep 14
American Airlines Logo
8:02 pm - 12:15 amSDF-DSM
5h 13m1 stop
American Airlines Logo
7:03 am - 4:48 pmDSM-SDF
8h 45m2 stops
$257American Airlines
Find Deal
Thu, Sep 18 - Tue, Sep 23
Southwest Logo
5:30 am - 11:25 amSDF-DSM
6h 55m2 stops
Southwest Logo
6:30 am - 3:15 pmDSM-SDF
7h 45m2 stops
$317Southwest
Find Deal
Wed, Sep 17 - Tue, Sep 23
Southwest Logo
6:25 am - 11:05 amSDF-DSM
5h 40m2 stops
Southwest Logo
6:30 am - 3:15 pmDSM-SDF
7h 45m2 stops
$322Southwest
Find Deal
Thu, Sep 18 - Tue, Sep 23
Delta Logo
12:50 pm - 5:45 pmSDF-DSM
5h 55m1 stop
Delta Logo
10:58 am - 6:52 pmDSM-SDF
6h 54m1 stop
$367Delta
Find Deal
Fri, Aug 15 - Tue, Aug 19
United Airlines Logo
3:25 pm - 8:24 pmSDF-DSM
5h 59m1 stop
United Airlines Logo
3:25 pm - 10:24 pmDSM-SDF
5h 59m1 stop
$427United Airlines
Find Deal
Sat, Aug 16 - Wed, Aug 20
United Airlines Logo
7:20 pm - 10:28 pmSDF-DSM
28h 08m2 stops
United Airlines Logo
3:25 pm - 10:30 pmDSM-SDF
6h 05m1 stop
$458United Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28

Delta flights from Louisville to Des Moines

Our best Delta deals on Louisville to Des Moines flight tickets
Delta
Sep 17
SDF7:10 amLouisville Intl
7h 10m
1 stop
DSM1:20 pmDes Moines
Sep 23
DSM6:00 amDes Moines
6h 42m
1 stop
SDF1:42 pmLouisville Intl
$197
Find similar
Delta
Aug 15
SDF12:50 pmLouisville Intl
5h 55m
1 stop
DSM5:45 pmDes Moines
Aug 19
DSM10:58 amDes Moines
6h 54m
1 stop
SDF6:52 pmLouisville Intl
$367
Find similar
Delta
Aug 10
SDF5:53 pmLouisville Intl
5h 40m
1 stop
DSM10:33 pmDes Moines
Aug 15
DSM2:12 pmDes Moines
6h 02m
1 stop
SDF9:14 pmLouisville Intl
$447
Find similar

American Airlines flights from Louisville to Des Moines

Our best American Airlines deals on Louisville to Des Moines flight tickets
American Airlines
Sep 17
SDF1:16 pmLouisville Intl
4h 33m
1 stop
DSM4:49 pmDes Moines
Sep 23
DSM7:03 amDes Moines
8h 45m
2 stops
SDF4:48 pmLouisville Intl
$202
Find similar
American Airlines
Sep 24
SDF1:16 pmLouisville Intl
4h 33m
1 stop
DSM4:49 pmDes Moines
Sep 26
DSM7:08 amDes Moines
5h 59m
1 stop
SDF2:07 pmLouisville Intl
$208
Find similar
American Airlines
Sep 12
SDF7:09 pmLouisville Intl
4h 57m
1 stop
DSM11:06 pmDes Moines
Sep 14
DSM5:11 amDes Moines
5h 33m
1 stop
SDF11:44 amLouisville Intl
$219
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 2, 2025.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/17

7:10 am-1:20 pm

1 stop7h 10m

Des Moines

Tue 9/23

6:00 am-1:42 pm

1 stop6h 42m

$197

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/17

1:16 pm-4:49 pm

1 stop4h 33m

Des Moines

Tue 9/23

7:03 am-4:48 pm

2 stops8h 45m

$202

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/24

1:16 pm-4:49 pm

1 stop4h 33m

Des Moines

Fri 9/26

7:08 am-2:07 pm

1 stop5h 59m

$208

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 9/12

7:09 pm-11:06 pm

1 stop4h 57m

Des Moines

Sun 9/14

5:11 am-11:44 am

1 stop5h 33m

$219

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 9/18

8:02 pm-12:15 am

1 stop5h 13m

Des Moines

Tue 9/23

7:03 am-4:48 pm

2 stops8h 45m

$257

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/17

5:30 am-11:25 am

2 stops6h 55m

Des Moines

Tue 9/23

6:30 am-3:15 pm

2 stops7h 45m

$317

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 9/18

6:25 am-11:05 am

2 stops5h 40m

Des Moines

Tue 9/23

6:30 am-3:15 pm

2 stops7h 45m

$322

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 8/15

12:50 pm-5:45 pm

1 stop5h 55m

Des Moines

Tue 8/19

10:58 am-6:52 pm

1 stop6h 54m

$367

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 8/16

3:25 pm-8:24 pm

1 stop5h 59m

Des Moines

Wed 8/20

3:25 pm-10:24 pm

1 stop5h 59m

$427

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 9/26

7:20 pm-10:28 pm

2 stops28h 08m

Des Moines

Sun 9/28

3:25 pm-10:30 pm

1 stop6h 05m

$458

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Louisville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Louisville to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $286. Flights from Louisville to Des Moines on a Wednesday will generally be more expensive and average around $417. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Louisville to Des Moines in the afternoon for as low as $365. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $437. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have Louisville to Des Moines flight prices changed over time?

When to book flights from Louisville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Des Moines (SDF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Des Moines

Best Price Found

$99

Fastest flight time

4h 27m

Direct flights

None

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Louisville in the past 72 hours is $99. The best round-trip flight deal from Louisville to Des Moines found on momondo in the last 72 hours is $197.
The fastest flight from Louisville to Des Moines takes 4h 27m
There are no direct flights from Louisville to Des Moines. Popular non-direct route for this connection is Louisville Intl Airport - Des Moines Airport.
There is 1 airport near Des Moines: Des Moines (DSM)
Search flight deals

  • How far is Louisville Intl to Des Moines by plane?

    Louisville Intl and Des Moines are 476.1 mi apart from one another. In terms of flight time, this usually takes a little over 4h 29m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Des Moines Airport?

    Prices for flights from Louisville Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Des Moines?

Best airlines flying from Louisville to Des Moines

Compare and see reviews for airlines that fly from Louisville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $105Free CancellationRating
8.0
7,985 reviews
Search Delta flights
United AirlinesPriceFrom $223Free CancellationRating
7.4
8,905 reviews
Search United Airlines flights
American AirlinesPriceFrom $241Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Newton
Pella
Boone
Johnston
Osceola
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Louisville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Louisville to Des Moines?

Once all potential Louisville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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