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Cheap flights from Louisville to Des Moines from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Des Moines departing on 6/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:00 am - 2:20 pm
SDF
-
DSM
4h 20m
1 stop
United Airlines Logo
6:55 pm - 11:59 pm
DSM
-
SDF
4h 04m
1 stop
$230United Airlines
Wed, Sep 23 - Sat, Sep 26
Delta Logo
5:30 pm - 8:49 pm
SDF
-
DSM
4h 19m
1 stop
Delta Logo
5:59 pm - 11:48 pm
DSM
-
SDF
4h 49m
1 stop
$260Delta
Wed, Sep 23 - Fri, Sep 25
Southwest Logo
8:45 am - 11:30 am
SDF
-
DSM
3h 45m
1 stop
Southwest Logo
5:20 am - 10:05 am
DSM
-
SDF
3h 45m
1 stop
$287Southwest
Wed, Jun 24 - Wed, Jul 1
United Airlines Logo
11:00 am - 2:20 pm
SDF
-
DSM
4h 20m
1 stop
United Airlines Logo
8:00 am - 7:09 pm
DSM
-
SDF
10h 09m
2 stops
$297United Airlines
Wed, Sep 23 - Sat, Sep 26
Delta Logo
6:00 am - 10:43 am
SDF
-
DSM
5h 43m
1 stop
Delta Logo
11:28 am - 5:00 pm
DSM
-
SDF
4h 32m
1 stop
$319Delta
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
8:30 am - 1:03 pm
SDF
-
DSM
5h 33m
1 stop
American Airlines Logo
6:30 am - 5:59 pm
DSM
-
SDF
10h 29m
2 stops
$324American Airlines
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
11:56 am - 7:14 pm
SDF
-
DSM
8h 18m
2 stops
American Airlines Logo
1:53 pm - 11:11 pm
DSM
-
SDF
8h 18m
2 stops
$329American Airlines
Sat, Aug 15 - Sat, Aug 22
United Airlines Logo
5:15 am - 10:31 am
SDF
-
DSM
6h 16m
1 stop
United Airlines Logo
6:55 pm - 11:59 pm
DSM
-
SDF
4h 04m
1 stop
$333United Airlines
Mon, Oct 12 - Fri, Oct 16
Southwest Logo
5:35 am - 10:45 pm
SDF
-
DSM
18h 10m
2 stops
Southwest Logo
5:20 am - 10:05 am
DSM
-
SDF
3h 45m
1 stop
$338Southwest
Wed, Jun 24 - Wed, Jul 1
Southwest Logo
6:20 pm - 11:30 pm
SDF
-
DSM
6h 10m
2 stops
Southwest Logo
4:30 pm - 8:55 pm
DSM
-
SDF
3h 25m
1 stop
$348Southwest
Mon, Oct 12 - Fri, Oct 16

Southwest flights from Louisville to Des Moines

Our best Southwest deals on Louisville to Des Moines flight tickets
Southwest
Jun 24
SDF8:45 amLouisville Intl
3h 45m
1 stop
DSM11:30 amDes Moines
Jul 1
DSM5:20 amDes Moines
3h 45m
1 stop
SDF10:05 amLouisville Intl
$287
Southwest
Jun 24
SDF5:35 amLouisville Intl
18h 10m
2 stops
DSM10:45 pmDes Moines
Jul 1
DSM5:20 amDes Moines
3h 45m
1 stop
SDF10:05 amLouisville Intl
$338
Southwest
Oct 12
SDF6:20 pmLouisville Intl
6h 10m
2 stops
DSM11:30 pmDes Moines
Oct 16
DSM4:30 pmDes Moines
3h 25m
1 stop
SDF8:55 pmLouisville Intl
$348

United Airlines flights from Louisville to Des Moines

Our best United Airlines deals on Louisville to Des Moines flight tickets
United Airlines
Sep 23
SDF11:00 amLouisville Intl
4h 20m
1 stop
DSM2:20 pmDes Moines
Sep 26
DSM6:55 pmDes Moines
4h 04m
1 stop
SDF11:59 pmLouisville Intl
$230
United Airlines
Sep 23
SDF11:00 amLouisville Intl
4h 20m
1 stop
DSM2:20 pmDes Moines
Sep 26
DSM8:00 amDes Moines
10h 09m
2 stops
SDF7:09 pmLouisville Intl
$297
United Airlines
Oct 12
SDF5:15 amLouisville Intl
6h 16m
1 stop
DSM10:31 amDes Moines
Oct 16
DSM6:55 pmDes Moines
4h 04m
1 stop
SDF11:59 pmLouisville Intl
$333

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 30, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/23

11:00 am-2:20 pm

1 stop4h 20m

Des Moines

Sat 9/26

6:55 pm-11:59 pm

1 stop4h 04m

$230

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/23

5:30 pm-8:49 pm

1 stop4h 19m

Des Moines

Fri 9/25

5:59 pm-11:48 pm

1 stop4h 49m

$260
Quickest round-trip

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 6/24

8:45 am-11:30 am

1 stop3h 45m

Des Moines

Wed 7/1

5:20 am-10:05 am

1 stop3h 45m

$287

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 9/23

11:00 am-2:20 pm

1 stop4h 20m

Des Moines

Sat 9/26

8:00 am-7:09 pm

2 stops10h 09m

$297

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 8/15

6:00 am-10:43 am

1 stop5h 43m

Des Moines

Sat 8/22

11:28 am-5:00 pm

1 stop4h 32m

$319

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 8/15

8:30 am-1:03 pm

1 stop5h 33m

Des Moines

Sat 8/22

6:30 am-5:59 pm

2 stops10h 29m

$324

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 8/15

11:56 am-7:14 pm

2 stops8h 18m

Des Moines

Sat 8/22

1:53 pm-11:11 pm

2 stops8h 18m

$329

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 10/12

5:15 am-10:31 am

1 stop6h 16m

Des Moines

Fri 10/16

6:55 pm-11:59 pm

1 stop4h 04m

$333

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 6/24

5:35 am-10:45 pm

2 stops18h 10m

Des Moines

Wed 7/1

5:20 am-10:05 am

1 stop3h 45m

$338

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 10/12

6:20 pm-11:30 pm

2 stops6h 10m

Des Moines

Fri 10/16

4:30 pm-8:55 pm

1 stop3h 25m

$348

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Louisville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Louisville and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then February is your next best option. Flight prices from Louisville to Des Moines during February average around $0.

How have Louisville to Des Moines flight prices changed over time?

When to book flights from Louisville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Des Moines (SDF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Des Moines

Fastest flight time

4h 20m

Direct flights

None
The fastest flight from Louisville to Des Moines takes 4h 20m
There are no direct flights from Louisville to Des Moines. There are no popular flight routes from Louisville to Des Moines.
Search flight deals

Frequently asked questions about flying from Louisville to Des Moines

  • How far is Louisville Intl to Des Moines by plane?

    Louisville Intl and Des Moines are 476.1 mi apart from one another. In terms of flight time, this usually takes a little over 4h 20m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Des Moines Airport?

    Prices for flights from Louisville Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Des Moines?

Best airlines flying from Louisville to Des Moines

Compare and see reviews for airlines that fly from Louisville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $158Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights
DeltaPriceFrom $196Free CancellationRating
7.9
8,417 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,766 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Boone
Osceola
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Louisville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Louisville to Des Moines?

Once all potential Louisville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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