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Cheap flights from Louisville to Des Moines from $251

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Des Moines departing on 3/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:38 pm - 11:42 pm
SDF
-
DSM
6h 04m
1 stop
American Airlines Logo
5:00 am - 11:32 am
DSM
-
SDF
5h 32m
1 stop
$251American Airlines
Tue, Mar 24 - Wed, Mar 25
American Airlines Logo
6:38 pm - 11:42 pm
SDF
-
DSM
6h 04m
1 stop
American Airlines Logo
1:37 pm - 10:40 pm
DSM
-
SDF
8h 03m
2 stops
$256American Airlines
Tue, Mar 24 - Wed, Mar 25
Delta Logo
10:40 am - 4:48 pm
SDF
-
DSM
7h 08m
1 stop
Delta Logo
10:26 am - 5:12 pm
DSM
-
SDF
5h 46m
1 stop
$317Delta
Fri, May 22 - Tue, May 26
Delta Logo
10:40 am - 4:48 pm
SDF
-
DSM
7h 08m
1 stop
Delta Logo
7:01 am - 11:59 am
DSM
-
SDF
3h 58m
1 stop
$327Delta
Fri, May 22 - Mon, May 25
Delta Logo
2:34 pm - 8:36 pm
SDF
-
DSM
7h 02m
1 stop
Delta Logo
6:20 am - 1:38 pm
DSM
-
SDF
6h 18m
1 stop
$363Delta
Fri, May 29 - Sun, Jun 7
Southwest Logo
8:55 am - 8:50 pm
SDF
-
DSM
12h 55m
2 stops
Southwest Logo
3:40 pm - 11:30 pm
DSM
-
SDF
6h 50m
2 stops
$365Southwest
Tue, Mar 24 - Wed, Mar 25
Southwest Logo
5:25 pm - 11:05 pm
SDF
-
DSM
6h 40m
2 stops
Southwest Logo
4:20 pm - 9:00 pm
DSM
-
SDF
3h 40m
1 stop
$382Southwest
Fri, May 22 - Mon, May 25
Southwest Logo
8:05 pm - 11:20 pm
SDF
-
DSM
4h 15m
1 stop
Southwest Logo
5:10 am - 10:15 am
DSM
-
SDF
4h 05m
1 stop
$393Southwest
Fri, Jul 17 - Sun, Jul 19
Southwest Logo
8:05 pm - 11:20 pm
SDF
-
DSM
4h 15m
1 stop
Southwest Logo
5:10 am - 3:25 pm
DSM
-
SDF
9h 15m
2 stops
$402Southwest
Fri, Jul 17 - Sun, Jul 19
Southwest Logo
8:00 pm - 11:45 pm
SDF
-
DSM
4h 45m
1 stop
Southwest Logo
5:10 am - 12:00 pm
DSM
-
SDF
5h 50m
2 stops
$418Southwest
Sun, Jun 21 - Fri, Jun 26

Southwest flights from Louisville to Des Moines

Our best Southwest deals on Louisville to Des Moines flight tickets
Southwest
Mar 24
SDF8:55 amLouisville Intl
12h 55m
2 stops
DSM8:50 pmDes Moines
Mar 25
DSM3:40 pmDes Moines
6h 50m
2 stops
SDF11:30 pmLouisville Intl
$365
Southwest
May 22
SDF5:25 pmLouisville Intl
6h 40m
2 stops
DSM11:05 pmDes Moines
May 25
DSM4:20 pmDes Moines
3h 40m
1 stop
SDF9:00 pmLouisville Intl
$382
Southwest
Jul 17
SDF8:05 pmLouisville Intl
4h 15m
1 stop
DSM11:20 pmDes Moines
Jul 19
DSM5:10 amDes Moines
4h 05m
1 stop
SDF10:15 amLouisville Intl
$393

Delta flights from Louisville to Des Moines

Our best Delta deals on Louisville to Des Moines flight tickets
Delta
May 22
SDF10:40 amLouisville Intl
7h 08m
1 stop
DSM4:48 pmDes Moines
May 26
DSM10:26 amDes Moines
5h 46m
1 stop
SDF5:12 pmLouisville Intl
$317
Delta
May 22
SDF10:40 amLouisville Intl
7h 08m
1 stop
DSM4:48 pmDes Moines
May 25
DSM7:01 amDes Moines
3h 58m
1 stop
SDF11:59 amLouisville Intl
$327
Delta
May 29
SDF2:34 pmLouisville Intl
7h 02m
1 stop
DSM8:36 pmDes Moines
Jun 7
DSM6:20 amDes Moines
6h 18m
1 stop
SDF1:38 pmLouisville Intl
$363

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 3/24

6:38 pm-11:42 pm

1 stop6h 04m

Des Moines

Wed 3/25

5:00 am-11:32 am

1 stop5h 32m

$251

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 3/24

6:38 pm-11:42 pm

1 stop6h 04m

Des Moines

Wed 3/25

1:37 pm-10:40 pm

2 stops8h 03m

$256

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/22

10:40 am-4:48 pm

1 stop7h 08m

Des Moines

Tue 5/26

10:26 am-5:12 pm

1 stop5h 46m

$317

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/22

10:40 am-4:48 pm

1 stop7h 08m

Des Moines

Mon 5/25

7:01 am-11:59 am

1 stop3h 58m

$327

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/29

2:34 pm-8:36 pm

1 stop7h 02m

Des Moines

Sun 6/7

6:20 am-1:38 pm

1 stop6h 18m

$363

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 3/24

8:55 am-8:50 pm

2 stops12h 55m

Des Moines

Wed 3/25

3:40 pm-11:30 pm

2 stops6h 50m

$365

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/22

5:25 pm-11:05 pm

2 stops6h 40m

Des Moines

Mon 5/25

4:20 pm-9:00 pm

1 stop3h 40m

$382

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 7/17

8:05 pm-11:20 pm

1 stop4h 15m

Des Moines

Sun 7/19

5:10 am-10:15 am

1 stop4h 05m

$393

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 7/17

8:05 pm-11:20 pm

1 stop4h 15m

Des Moines

Sun 7/19

5:10 am-3:25 pm

2 stops9h 15m

$402

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sun 6/21

8:00 pm-11:45 pm

1 stop4h 45m

Des Moines

Fri 6/26

5:10 am-12:00 pm

2 stops5h 50m

$418

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Louisville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Louisville to Des Moines flight prices changed over time?

When to book flights from Louisville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Des Moines (SDF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Des Moines

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from Louisville to Des Moines takes 4h 17m
There are no direct flights from Louisville to Des Moines. There are no popular flight routes from Louisville to Des Moines.
Search flight deals

  • How far is Louisville Intl to Des Moines by plane?

    Louisville Intl and Des Moines are 476.1 mi apart from one another. In terms of flight time, this usually takes a little over 4h 17m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Des Moines Airport?

    Prices for flights from Louisville Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Louisville Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Louisville Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Louisville to Des Moines?

Best airlines flying from Louisville to Des Moines

Compare and see reviews for airlines that fly from Louisville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $105Free CancellationRating
7.9
8,242 reviews
Search Delta flights
American AirlinesPriceFrom $158Free CancellationRating
7.2
11,357 reviews
Search American Airlines flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,349 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Louisville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Louisville to Des Moines?

Once all potential Louisville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Louisville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Louisville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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