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Cheap flights from Lexington to Des Moines from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Lexington to Des Moines departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Lexington to Des Moines

Cheap round-trip flights

American Airlines Logo
6:39 pm - 11:16 pmLEX-DSM
5h 37m1 stop
American Airlines Logo
5:00 am - 11:45 amDSM-LEX
5h 45m1 stop
$249American Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
United Airlines Logo
6:01 pm - 9:50 pmLEX-DSM
4h 49m1 stop
United Airlines Logo
8:00 am - 3:48 pmDSM-LEX
6h 48m1 stop
$259United Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11
American Airlines Logo
6:00 am - 12:19 pmLEX-DSM
7h 19m1 stop
American Airlines Logo
6:12 pm - 12:20 amDSM-LEX
5h 08m1 stop
$294American Airlines
Find Deal
Thu, Oct 23 - Tue, Oct 28
American Airlines Logo
6:00 am - 1:18 pmLEX-DSM
8h 18m2 stops
American Airlines Logo
5:00 am - 10:42 amDSM-LEX
4h 42m1 stop
$304American Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11
American Airlines Logo
3:50 pm - 9:52 pmLEX-DSM
7h 02m1 stop
American Airlines Logo
4:27 pm - 8:52 pmDSM-LEX
3h 25m1 stop
$319American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
3:50 pm - 9:52 pmLEX-DSM
7h 02m1 stop
American Airlines Logo
12:47 pm - 9:52 pmDSM-LEX
8h 05m2 stops
$324American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
6:39 pm - 11:16 pmLEX-DSM
5h 37m1 stop
American Airlines Logo
5:00 am - 3:22 pmDSM-LEX
9h 22m2 stops
$327American Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
American Airlines Logo
8:49 am - 2:26 pmLEX-DSM
6h 37m2 stops
American Airlines Logo
12:47 pm - 11:55 pmDSM-LEX
10h 08m2 stops
$329American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
6:00 am - 12:19 pmLEX-DSM
7h 19m1 stop
American Airlines Logo
5:00 am - 3:22 pmDSM-LEX
9h 22m2 stops
$343American Airlines
Find Deal
Thu, Oct 23 - Tue, Oct 28
Delta Logo
5:55 am - 10:23 amLEX-DSM
5h 28m1 stop
Delta Logo
10:15 am - 5:13 pmDSM-LEX
5h 58m1 stop
$467Delta
Find Deal
Wed, Feb 25 - Thu, Feb 26

American Airlines flights from Lexington to Des Moines

Our best American Airlines deals on Lexington to Des Moines flight tickets
American Airlines
Oct 25
LEX6:39 pmLexington Blue Grass
5h 37m
1 stop
DSM11:16 pmDes Moines
Oct 28
DSM5:00 amDes Moines
5h 45m
1 stop
LEX11:45 amLexington Blue Grass
$249
Find similar
American Airlines
Oct 23
LEX6:00 amLexington Blue Grass
7h 19m
1 stop
DSM12:19 pmDes Moines
Oct 28
DSM6:12 pmDes Moines
5h 08m
1 stop
LEX12:20 amLexington Blue Grass
$294
Find similar
American Airlines
Oct 7
LEX6:00 amLexington Blue Grass
8h 18m
2 stops
DSM1:18 pmDes Moines
Oct 11
DSM5:00 amDes Moines
4h 42m
1 stop
LEX10:42 amLexington Blue Grass
$304
Find similar

United Airlines flights from Lexington to Des Moines

Our best United Airlines deals on Lexington to Des Moines flight tickets
United Airlines
Oct 7
LEX6:01 pmLexington Blue Grass
4h 49m
1 stop
DSM9:50 pmDes Moines
Oct 11
DSM8:00 amDes Moines
6h 48m
1 stop
LEX3:48 pmLexington Blue Grass
$259
Find similar
United Airlines
Oct 2
LEX6:01 pmLexington Blue Grass
4h 49m
1 stop
DSM9:50 pmDes Moines
Oct 5
DSM6:36 pmDes Moines
4h 23m
1 stop
LEX11:59 pmLexington Blue Grass
$407
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Lexington to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 24, 2025.
Use the filters below to find and compare flights from Lexington to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Sat 10/25

6:39 pm-11:16 pm

1 stop5h 37m

Des Moines

Tue 10/28

5:00 am-11:45 am

1 stop5h 45m

$249

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Tue 10/7

6:01 pm-9:50 pm

1 stop4h 49m

Des Moines

Sat 10/11

8:00 am-3:48 pm

1 stop6h 48m

$259

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Thu 10/23

6:00 am-12:19 pm

1 stop7h 19m

Des Moines

Tue 10/28

6:12 pm-12:20 am

1 stop5h 08m

$294

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Tue 10/7

6:00 am-1:18 pm

2 stops8h 18m

Des Moines

Sat 10/11

5:00 am-10:42 am

1 stop4h 42m

$304

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Wed 2/18

3:50 pm-9:52 pm

1 stop7h 02m

Des Moines

Sat 2/21

4:27 pm-8:52 pm

1 stop3h 25m

$319

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Wed 2/18

3:50 pm-9:52 pm

1 stop7h 02m

Des Moines

Sat 2/21

12:47 pm-9:52 pm

2 stops8h 05m

$324

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Sat 10/25

6:39 pm-11:16 pm

1 stop5h 37m

Des Moines

Tue 10/28

5:00 am-3:22 pm

2 stops9h 22m

$327

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Wed 2/18

8:49 am-2:26 pm

2 stops6h 37m

Des Moines

Sat 2/21

12:47 pm-11:55 pm

2 stops10h 08m

$329

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Thu 10/23

6:00 am-12:19 pm

1 stop7h 19m

Des Moines

Tue 10/28

5:00 am-3:22 pm

2 stops9h 22m

$343

LexingtonDes Moines

LEX - DSM

LEXDSM

Lexington Blue Grass

Wed 2/25

5:55 am-10:23 am

1 stop5h 28m

Des Moines

Thu 2/26

10:15 am-5:13 pm

1 stop5h 58m

$467

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Lexington to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Lexington to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $264. Flights from Lexington to Des Moines on a Saturday will generally be more expensive and average around $350. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Lexington to Des Moines in the morning for as low as $293. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $325. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Lexington to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Lexington to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Lexington to Des Moines (LEX to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Lexington to Des Moines

Direct flights

None
There are no direct flights from Lexington to Des Moines. There are no popular flight routes from Lexington to Des Moines.
Search flight deals

  • How far is Lexington Blue Grass to Des Moines by plane?

    The distance between Lexington Blue Grass and Des Moines is about 542.1 mi. By plane, this route typically takes 4h 49m.

  • When did momondo last update prices for flights from Lexington Blue Grass Airport to Des Moines Airport?

    Prices for flights from Lexington Blue Grass Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Lexington Blue Grass Airport to Des Moines Airport?

  • How old do you have to be to fly from Lexington Blue Grass Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lexington Blue Grass Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Lexington to Des Moines?

Best airlines flying from Lexington to Des Moines

Compare and see reviews for airlines that fly from Lexington to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
7,973 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $272Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Lexington to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Lexington.

Can I find flights from Lexington to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Lexington on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Lexington to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Lexington.

I’m not ready to book a flight from Lexington to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Lexington to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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