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Cheap flights from Knoxville to Mexico City Federal District from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Mexico City Federal District departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Mexico City Federal District

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:59 pm - 10:30 pm
TYS
-
MEX
29h 31m2 stops
Multiple Airlines Logo
7:00 am - 8:39 am
MEX
-
TYS
24h 39m2 stops
$430Multiple Airlines
Sat, Jan 31 - Sat, Feb 7
Multiple Airlines Logo
12:55 pm - 7:45 pm
TYS
-
MEX
7h 50m1 stop
Multiple Airlines Logo
10:20 pm - 8:39 am
MEX
-
TYS
33h 19m2 stops
$439Multiple Airlines
Fri, Jan 30 - Fri, Feb 6
Multiple Airlines Logo
5:59 pm - 11:35 pm
TYS
-
MEX
30h 36m3 stops
Multiple Airlines Logo
7:00 am - 8:39 am
MEX
-
TYS
24h 39m2 stops
$441Multiple Airlines
Sat, Jan 31 - Sat, Feb 7
Multiple Airlines Logo
5:59 pm - 11:35 pm
TYS
-
MEX
30h 36m3 stops
Multiple Airlines Logo
7:00 am - 8:39 am
MEX
-
TYS
24h 39m3 stops
$459Multiple Airlines
Sat, Jan 31 - Sat, Feb 7
American Airlines Logo
6:00 am - 7:36 pm
TYS
-
MEX
14h 36m1 stop
American Airlines Logo
6:45 am - 5:06 pm
MEX
-
TYS
9h 21m1 stop
$501American Airlines
Fri, Jan 30 - Fri, Feb 6
Multiple Airlines Logo
2:54 pm - 10:00 pm
TYS
-
MEX
32h 06m2 stops
Multiple Airlines Logo
11:10 am - 5:03 pm
MEX
-
TYS
28h 53m1 stop
$506Multiple Airlines
Sat, Feb 14 - Wed, Feb 25
Multiple Airlines Logo
7:15 am - 10:45 am
TYS
-
MEX
29h 30m2 stops
Multiple Airlines Logo
11:10 am - 12:51 pm
MEX
-
TYS
23h 41m1 stop
$540Multiple Airlines
Mon, Mar 16 - Tue, Mar 24
American Airlines Logo
7:39 pm - 8:55 am
TYS
-
MEX
15h 16m1 stop
American Airlines Logo
10:20 am - 9:05 pm
MEX
-
TYS
8h 45m1 stop
$550American Airlines
Mon, Mar 16 - Tue, Mar 24
Delta Logo
7:07 am - 3:30 pm
TYS
-
MEX
10h 23m2 stops
Delta Logo
9:40 am - 9:44 pm
MEX
-
TYS
10h 04m2 stops
$555Delta
Tue, May 12 - Mon, May 18
Aeromexico Logo
5:40 am - 11:20 am
TYS
-
MEX
6h 40m1 stop
Aeromexico Logo
4:35 pm - 11:45 pm
MEX
-
TYS
6h 10m1 stop
$563Aeromexico
Sat, Jan 31 - Sat, Feb 7

American Airlines flights from Knoxville to Mexico City Federal District

Our best American Airlines deals on Knoxville to Mexico City Federal District flight tickets
American Airlines
Jan 30
TYS6:00 amKnoxville McGhee Tyson
14h 36m
1 stop
MEX7:36 pmMexico City Benito Juarez
Feb 6
MEX6:45 amMexico City Benito Juarez
9h 21m
1 stop
TYS5:06 pmKnoxville McGhee Tyson
$501
Find similar
American Airlines
Mar 16
TYS7:39 pmKnoxville McGhee Tyson
15h 16m
1 stop
MEX8:55 amMexico City Benito Juarez
Mar 24
MEX10:20 amMexico City Benito Juarez
8h 45m
1 stop
TYS9:05 pmKnoxville McGhee Tyson
$550
Find similar
American Airlines
Mar 8
TYS12:24 pmKnoxville McGhee Tyson
8h 11m
1 stop
MEX6:35 pmMexico City Benito Juarez
Mar 11
MEX12:45 pmMexico City Benito Juarez
8h 55m
1 stop
TYS11:40 pmKnoxville McGhee Tyson
$590
Find similar

Delta flights from Knoxville to Mexico City Federal District

Our best Delta deals on Knoxville to Mexico City Federal District flight tickets
Delta
May 12
TYS2:30 pmKnoxville McGhee Tyson
8h 51m
1 stop
MEX9:21 pmMexico City Benito Juarez
May 18
MEX9:20 amMexico City Benito Juarez
12h 26m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
$555
Find similar
Delta
Feb 14
TYS8:22 amKnoxville McGhee Tyson
11h 23m
2 stops
MEX6:45 pmMexico City Benito Juarez
Feb 25
MEX8:35 amMexico City Benito Juarez
10h 25m
2 stops
TYS8:00 pmKnoxville McGhee Tyson
$575
Find similar
Delta
Mar 16
TYS5:30 amKnoxville McGhee Tyson
11h 05m
2 stops
MEX2:35 pmMexico City Benito Juarez
Mar 24
MEX10:35 amMexico City Benito Juarez
11h 16m
2 stops
TYS11:51 pmKnoxville McGhee Tyson
$594
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Mexico City Federal District that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Mexico City Federal District that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sat 1/31

5:59 pm-10:30 pm

2 stops29h 31m

Mexico City Benito Juarez

Sat 2/7

7:00 am-8:39 am

2 stops24h 39m

$430

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Fri 1/30

12:55 pm-7:45 pm

1 stop7h 50m

Mexico City Benito Juarez

Fri 2/6

10:20 pm-8:39 am

2 stops33h 19m

$439

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sat 1/31

5:59 pm-11:35 pm

3 stops30h 36m

Mexico City Benito Juarez

Sat 2/7

7:00 am-8:39 am

2 stops24h 39m

$441

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sat 1/31

5:59 pm-11:35 pm

3 stops30h 36m

Mexico City Benito Juarez

Sat 2/7

7:00 am-8:39 am

3 stops24h 39m

$459

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Fri 1/30

6:00 am-7:36 pm

1 stop14h 36m

Mexico City Benito Juarez

Fri 2/6

6:45 am-5:06 pm

1 stop9h 21m

$501

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sat 2/14

2:54 pm-10:00 pm

2 stops32h 06m

Mexico City Benito Juarez

Wed 2/25

11:10 am-5:03 pm

1 stop28h 53m

$506

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Mon 3/16

7:15 am-10:45 am

2 stops29h 30m

Mexico City Benito Juarez

Tue 3/24

11:10 am-12:51 pm

1 stop23h 41m

$540

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Mon 3/16

7:39 pm-8:55 am

1 stop15h 16m

Mexico City Benito Juarez

Tue 3/24

10:20 am-9:05 pm

1 stop8h 45m

$550

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Tue 5/12

7:07 am-3:30 pm

2 stops10h 23m

Mexico City Benito Juarez

Mon 5/18

9:40 am-9:44 pm

2 stops10h 04m

$555

KnoxvilleMexico City

TYS - MEX

TYSMEX

Knoxville McGhee Tyson

Sat 1/31

5:40 am-11:20 am

1 stop6h 40m

Mexico City Benito Juarez

Sat 2/7

4:35 pm-11:45 pm

1 stop6h 10m

$563

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Mexico City Federal District from

How to get the cheapest flight ticket from Knoxville to Mexico City Federal District

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Mexico City Federal District?

If you are unable to visit Mexico City Federal District during the month of April, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $546.

What is the cheapest day to depart on your flight to Mexico City Federal District?

The cheapest day to depart on your flight to Mexico City Federal District is on a Wednesday when prices can be found for as low as $657. This is often the case because there is less demand to fly during this day of the week. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Mexico City Federal District for around $798.

What is the cheapest time of day to depart on your flight to Mexico City Federal District?

The cheapest time of day to fly to Mexico City Federal District is at noon when flights can be purchased for as low as $678. In the afternoon is when there is more demand to fly to Mexico City Federal District, so prices are often more expensive at around $884 per ticket.

Cheap Knoxville to Mexico City Federal District flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Mexico City Federal District

Fastest flight time

5h 51m

Direct flights

None
The fastest flight from Knoxville to Mexico City Federal District takes 5h 51m
There are no direct flights from Knoxville to Mexico City Federal District. There are no popular flight routes from Knoxville to Mexico City Federal District.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Mexico City Federal District?

    Prices for flights from Knoxville McGhee Tyson Airport to Mexico City Federal District are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Mexico City Federal District?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Mexico City Federal District?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Mexico City Federal District.

  • What documentation or ID do you need to fly to Mexico City Federal District?

    The travel and health documents required for your trip to Mexico City Federal District can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Mexico City Federal District. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to Mexico City Federal District

Compare and see reviews for airlines that fly from Knoxville to Mexico City Federal District with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $318Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $455Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Mexico City Federal District?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Mexico City Federal District. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Mexico City Federal District with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Mexico City Federal District flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Mexico City Federal District?

momondo helps you find the best flight between Knoxville and Mexico City Federal District by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Mexico City Federal District right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Mexico City Federal District flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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