What airlines fly to South America?

Spirit Airlines, Delta and American Airlines are the top three most popular airlines that fly to South America from Columbus Airport according to our data. Spirit Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 6 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Columbus to South America?

Spirit Airlines, Copa Airlines, and American Airlines are the most popular carriers operating from Columbus to South America

When did momondo last update prices for flights from Columbus Airport to South America?

Prices for flights from Columbus Airport to South America are refreshed on a daily basis.

How many operators does momondo search for flights from Columbus Airport to South America?

There are 5 operators available for flights from Columbus Airport to South America as of March 2026.

How old do you have to be to fly from Columbus Airport to South America?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Columbus Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$172 Cheap Flights from Columbus Airport to South America in 2026

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Find the cheapest flights from Columbus Airport to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:05 am - 12:52 pm

CMH

MDE

7h 47m

1 stop

10:49 am - 3:27 pm

MDE

CMH

27h 38m

1 stop

$377Spirit Airlines

Tue, Apr 7 - Tue, Apr 14

6:05 am - 9:51 am

CMH

MDE

28h 46m

1 stop

10:49 am - 3:27 pm

MDE

CMH

27h 38m

1 stop

$387Spirit Airlines

Tue, Apr 7 - Tue, Apr 14

6:05 am - 12:52 pm

CMH

MDE

7h 47m

1 stop

1:52 pm - 3:27 pm

MDE

CMH

24h 35m

1 stop

$389Spirit Airlines

Tue, Apr 7 - Tue, Apr 14

7:05 am - 12:58 pm

CMH

CTG

6h 53m

1 stop

2:13 pm - 12:25 am

CTG

CMH

9h 12m

1 stop

$552Delta

Tue, May 12 - Tue, May 19

5:05 am - 12:09 pm

CMH

CTG

8h 04m

2 stops

1:25 pm - 10:45 am

CTG

CMH

20h 20m

2 stops

$557American Airlines

Tue, May 12 - Tue, May 19

6:00 am - 7:35 pm

CMH

CTG

14h 35m

2 stops

2:13 pm - 12:25 am

CTG

CMH

9h 12m

1 stop

$559Delta

Tue, May 12 - Tue, May 19

5:05 am - 12:09 pm

CMH

CTG

8h 04m

2 stops

1:25 pm - 10:42 am

CTG

CMH

20h 17m

2 stops

$578American Airlines

Tue, Apr 28 - Tue, May 5

10:05 am - 5:35 am

CMH

SCL

19h 30m

2 stops

10:55 pm - 5:32 pm

SCL

CMH

18h 37m

1 stop

$901LATAM Airlines

Sun, Jul 19 - Wed, Aug 26

7:07 am - 6:50 am

CMH

SCL

23h 43m

1 stop

8:40 pm - 7:04 pm

SCL

CMH

22h 24m

1 stop

$917LATAM Airlines

Wed, May 13 - Wed, May 20

9:55 am - 7:40 am

CMH

SDU

44h 45m

2 stops

1:45 pm - 3:22 pm

SDU

CMH

26h 37m

2 stops

$1,308Air Canada

Sun, May 24 - Mon, Jun 1

Spirit Airlines flights from Columbus Airport to South America

Our best Spirit Airlines deals on Columbus Airport to South America flight tickets

Spirit Airlines

Apr 7

CMH6:05 amColumbus

7h 47m

1 stop

MDE12:52 pmMedellín Jose Maria Cordova Intl

Apr 14

MDE10:49 amMedellín Jose Maria Cordova Intl

27h 38m

1 stop

CMH3:27 pmColumbus

$377

Spirit Airlines

Apr 7

CMH6:05 amColumbus

28h 46m

1 stop

MDE9:51 amMedellín Jose Maria Cordova Intl

Apr 14

MDE10:49 amMedellín Jose Maria Cordova Intl

27h 38m

1 stop

CMH3:27 pmColumbus

$387

Spirit Airlines

Apr 7

CMH6:05 amColumbus

7h 47m

1 stop

MDE12:52 pmMedellín Jose Maria Cordova Intl

Apr 14

MDE1:52 pmMedellín Jose Maria Cordova Intl

24h 35m

1 stop

CMH3:27 pmColumbus

$389

United Airlines flights from Columbus Airport to South America

Our best United Airlines deals on Columbus Airport to South America flight tickets

United Airlines

Apr 30

CMH11:37 amColumbus

8h 43m

1 stop

BOG7:20 pmBogotá El Dorado

May 7

BOG8:30 amBogotá El Dorado

12h 41m

1 stop

CMH10:11 pmColumbus

$630

United Airlines

Jun 11

CMH11:35 amColumbus

11h 25m

1 stop

BOG10:00 pmBogotá El Dorado

Jun 20

BOG12:14 amBogotá El Dorado

9h 48m

1 stop

CMH11:02 amColumbus

$634

United Airlines

Jun 12

CMH11:35 amColumbus

11h 25m

1 stop

BOG10:00 pmBogotá El Dorado

Jun 20

BOG12:14 amBogotá El Dorado

9h 48m

1 stop

CMH11:02 amColumbus

$644

momondo Fare Finder

Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Tue 4/7

6:05 am-12:52 pm

1 stop7h 47m

Medellín Jose Maria Cordova Intl

Tue 4/14

10:49 am-3:27 pm

1 stop27h 38m

$377

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Tue 4/7

6:05 am-9:51 am

1 stop28h 46m

Medellín Jose Maria Cordova Intl

Tue 4/14

10:49 am-3:27 pm

1 stop27h 38m

$387

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Tue 4/7

6:05 am-12:52 pm

1 stop7h 47m

Medellín Jose Maria Cordova Intl

Tue 4/14

1:52 pm-3:27 pm

1 stop24h 35m

$389

Quickest round-trip

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Tue 5/12

7:05 am-12:58 pm

1 stop6h 53m

Cartagena Rafael Nunez

Tue 5/19

2:13 pm-12:25 am

1 stop9h 12m

$552

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Tue 5/12

5:05 am-12:09 pm

2 stops8h 04m

Cartagena Rafael Nunez

Tue 5/19

1:25 pm-10:45 am

2 stops20h 20m

$557

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Tue 5/12

6:00 am-7:35 pm

2 stops14h 35m

Cartagena Rafael Nunez

Tue 5/19

2:13 pm-12:25 am

1 stop9h 12m

$559

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Tue 4/28

5:05 am-12:09 pm

2 stops8h 04m

Cartagena Rafael Nunez

Tue 5/5

1:25 pm-10:42 am

2 stops20h 17m

$578

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Sun 7/19

10:05 am-5:35 am

2 stops19h 30m

Santiago Arturo Merino Benitez

Wed 8/26

10:55 pm-5:32 pm

1 stop18h 37m

$901

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

Wed 5/13

7:07 am-6:50 am

1 stop23h 43m

Santiago Arturo Merino Benitez

Wed 5/20

8:40 pm-7:04 pm

1 stop22h 24m

$917

ColumbusRio de Janeiro

CMH - SDU

CMHSDU

Columbus

Sun 5/24

9:55 am-7:40 am

2 stops44h 45m

Rio de Janeiro Santos Dumont

Mon 6/1

1:45 pm-3:22 pm

2 stops26h 37m

$1,308

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Columbus Airport to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, January is the cheapest month to fly from Columbus Airport to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $443. If you aren’t able to travel during the month of January, then book flights to South America from Columbus Airport during September instead. Flights to South America in September, while not as cheap as those in January, still average around $723.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Columbus Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $828 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Columbus Airport for as low as $558 on momondo.

Can stopping save me money on Columbus Airport to South America flights?

You could potentially save up to 66% on your flight if you consider stops on a Columbus Airport to South America flight.

Cheap Columbus Airport to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to South America

Fastest flight time	6h 53m
Direct flights	None

The fastest flight from Columbus Airport to South America takes 6h 53m

There are no direct flights from Columbus Airport to South America. There are no popular flight routes from Columbus Airport to South America.

Search flight deals

When did momondo last update prices for flights from Columbus Airport to South America?
Prices for flights from Columbus Airport to South America are refreshed on a daily basis.
How many operators does momondo search for flights from Columbus Airport to South America?
There are 5 operators available for flights from Columbus Airport to South America as of March 2026.
How old do you have to be to fly from Columbus Airport to South America?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Columbus Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Columbus Airport to South America

Compare and see reviews for airlines that fly from Columbus Airport to South America with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $244	Free Cancellation	Rating 6.3 8,520 reviews	Search Spirit Airlines flights
American Airlines	PriceFrom $490	Free Cancellation	Rating 7.1 11,468 reviews	Search American Airlines flights
Delta	PriceFrom $552	Free Cancellation	Rating 7.9 8,288 reviews	Search Delta flights
LATAM Airlines	PriceFrom $658	Free Cancellation	Rating 7.4 1,917 reviews	Search LATAM Airlines flights
Air Canada	PriceFrom $744	Free Cancellation	Rating 7.1 10,811 reviews	Search Air Canada flights
United Airlines	PriceFrom $962	Free Cancellation	Rating 7.4 9,431 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to South America?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to South America. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Columbus with this policy.

How can momondo help me find flights from Columbus to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Columbus to South America.

I’m not ready to book a flight from Columbus to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Columbus are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.