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Cheap flights from Columbus Airport to South America from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to South America departing on 11/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbus Airport to South America

Cheap round-trip flights

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Spirit Airlines Logo
5:25 am - 1:15 pmCMH-CTG
7h 50m1 stop
Spirit Airlines Logo
2:20 pm - 11:10 pmCTG-CMH
8h 50m1 stop
$296Spirit Airlines
Find Deal
Sun, Nov 9 - Thu, Nov 13
Spirit Airlines Logo
5:25 am - 1:15 pmCMH-CTG
7h 50m1 stop
Spirit Airlines Logo
2:20 pm - 11:10 pmCTG-CMH
8h 50m1 stop
$301Spirit Airlines
Find Deal
Sun, Nov 9 - Thu, Nov 13
Delta Logo
7:05 am - 2:15 pmCMH-CTG
7h 10m1 stop
Delta Logo
3:30 pm - 11:57 pmCTG-CMH
8h 27m1 stop
$553Delta
Find Deal
Sat, Feb 7 - Thu, Feb 12
United Airlines Logo
10:26 am - 10:35 pmCMH-BOG
12h 09m2 stops
United Airlines Logo
1:30 am - 3:45 pmBOG-CMH
14h 15m1 stop
$553United Airlines
Find Deal
Thu, Nov 13 - Wed, Nov 19
American Airlines Logo
7:12 pm - 3:30 pmCMH-CTG
20h 18m2 stops
American Airlines Logo
9:05 am - 10:19 pmCTG-CMH
13h 14m2 stops
$558American Airlines
Find Deal
Sat, Feb 7 - Thu, Feb 12
United Airlines Logo
11:39 am - 11:05 pmCMH-BOG
11h 26m1 stop
United Airlines Logo
1:30 am - 4:42 pmBOG-CMH
15h 12m2 stops
$558United Airlines
Find Deal
Mon, Nov 10 - Wed, Nov 12
American Airlines Logo
9:58 am - 10:10 pmCMH-BOG
13h 12m2 stops
American Airlines Logo
11:55 pm - 7:03 pmBOG-CMH
19h 08m1 stop
$578American Airlines
Find Deal
Sat, Nov 1 - Sun, Nov 2
LATAM Airlines Logo
9:55 am - 8:00 pmCMH-UIO
10h 05m1 stop
LATAM Airlines Logo
11:45 pm - 11:38 amUIO-CMH
11h 53m1 stop
$710LATAM Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
LATAM Airlines Logo
3:40 pm - 5:17 amCMH-UIO
37h 37m2 stops
LATAM Airlines Logo
7:00 pm - 11:57 pmUIO-CMH
27h 57m2 stops
$724LATAM Airlines
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Sat, Mar 7 - Sun, Mar 15
Delta Logo
5:30 pm - 9:55 amCMH-GRU
15h 25m1 stop
Delta Logo
10:50 pm - 4:54 pmGRU-CMH
19h 04m1 stop
$1,040Delta
Find Deal
Mon, Mar 16 - Tue, Mar 31

United Airlines flights from Columbus Airport to South America

Our best United Airlines deals on Columbus Airport to South America flight tickets
United Airlines
Oct 29
CMH4:45 pmColumbus
13h 25m
1 stop
BOG5:10 amBogotá El Dorado
Nov 4
BOG1:30 amBogotá El Dorado
13h 52m
2 stops
CMH3:22 pmColumbus
$538
Find similar
United Airlines
Oct 29
CMH6:30 amColumbus
17h 05m
1 stop
BOG10:35 pmBogotá El Dorado
Nov 5
BOG8:15 amBogotá El Dorado
13h 57m
1 stop
CMH10:12 pmColumbus
$551
Find similar
United Airlines
Nov 13
CMH10:26 amColumbus
12h 09m
2 stops
BOG10:35 pmBogotá El Dorado
Nov 19
BOG1:30 amBogotá El Dorado
14h 15m
1 stop
CMH3:45 pmColumbus
$553
Find similar

American Airlines flights from Columbus Airport to South America

Our best American Airlines deals on Columbus Airport to South America flight tickets
American Airlines
Feb 7
CMH7:12 pmColumbus
20h 18m
2 stops
CTG3:30 pmCartagena Rafael Nunez
Feb 12
CTG9:05 amCartagena Rafael Nunez
13h 14m
2 stops
CMH10:19 pmColumbus
$558
Find similar
American Airlines
Nov 1
CMH9:58 amColumbus
13h 12m
2 stops
BOG10:10 pmBogotá El Dorado
Nov 2
BOG11:55 pmBogotá El Dorado
19h 08m
1 stop
CMH7:03 pmColumbus
$578
Find similar
American Airlines
Apr 15
CMH8:43 amColumbus
12h 07m
1 stop
MDE7:50 pmMedellín Jose Maria Cordova Intl
Apr 21
MDE5:50 amMedellín Jose Maria Cordova Intl
15h 30m
1 stop
CMH10:20 pmColumbus
$579
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Sun 11/9

5:25 am-1:15 pm

1 stop7h 50m

Cartagena Rafael Nunez

Thu 11/13

2:20 pm-11:10 pm

1 stop8h 50m

$296

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Sun 11/9

5:25 am-1:15 pm

1 stop7h 50m

Cartagena Rafael Nunez

Thu 11/13

2:20 pm-11:10 pm

1 stop8h 50m

$301

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Sat 2/7

7:05 am-2:15 pm

1 stop7h 10m

Cartagena Rafael Nunez

Thu 2/12

3:30 pm-11:57 pm

1 stop8h 27m

$553

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Thu 11/13

10:26 am-10:35 pm

2 stops12h 09m

Bogotá El Dorado

Wed 11/19

1:30 am-3:45 pm

1 stop14h 15m

$553

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Sat 2/7

7:12 pm-3:30 pm

2 stops20h 18m

Cartagena Rafael Nunez

Thu 2/12

9:05 am-10:19 pm

2 stops13h 14m

$558

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Mon 11/10

11:39 am-11:05 pm

1 stop11h 26m

Bogotá El Dorado

Wed 11/12

1:30 am-4:42 pm

2 stops15h 12m

$558

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Sat 11/1

9:58 am-10:10 pm

2 stops13h 12m

Bogotá El Dorado

Sun 11/2

11:55 pm-7:03 pm

1 stop19h 08m

$578

ColumbusQuito

CMH - UIO

CMHUIO

Columbus

Thu 12/4

9:55 am-8:00 pm

1 stop10h 05m

Quito Mariscal Sucr

Thu 12/11

11:45 pm-11:38 am

1 stop11h 53m

$710

ColumbusQuito

CMH - UIO

CMHUIO

Columbus

Sat 3/7

3:40 pm-5:17 am

2 stops37h 37m

Quito Mariscal Sucr

Sun 3/15

7:00 pm-11:57 pm

2 stops27h 57m

$724

ColumbusSao Paulo

CMH - GRU

CMHGRU

Columbus

Mon 3/16

5:30 pm-9:55 am

1 stop15h 25m

Sao Paulo Guarulhos Intl

Tue 3/31

10:50 pm-4:54 pm

1 stop19h 04m

$1,040

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Columbus Airport to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, January is the cheapest month to fly from Columbus Airport to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $683. If you aren’t able to travel during the month of January, then book flights to South America from Columbus Airport during February instead. Flights to South America in February, while not as cheap as those in January, still average around $707.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Columbus Airport to South America is on a Wednesday when prices can be found for as low as $776. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Columbus Airport to South America for around $1,087.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Columbus Airport to South America flights are usually those with departure times at noon. Our users have found flights to South America at noon for as low as $818. If you have a flexible travel schedule, then try to avoid flying in the evening when prices are $851 on average. Flights to South America from Columbus Airport in the evening are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Columbus Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $812 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Columbus Airport for as low as $691 on momondo.

Can stopping save me money on Columbus Airport to South America flights?

You could potentially save up to 21% on your flight if you consider stops on a Columbus Airport to South America flight.

Cheap Columbus Airport to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to South America

Direct flights

None
There are no direct flights from Columbus Airport to South America. There are no popular flight routes from Columbus Airport to South America.
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  • When did momondo last update prices for flights from Columbus Airport to South America?

    Prices for flights from Columbus Airport to South America are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbus Airport to South America?

  • How old do you have to be to fly from Columbus Airport to South America?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Columbus Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Columbus Airport to South America

Compare and see reviews for airlines that fly from Columbus Airport to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $261Free CancellationRating
6.3
8,098 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $490Free CancellationRating
7.2
11,028 reviews
Search American Airlines flights
United AirlinesPriceFrom $534Free CancellationRating
7.4
8,988 reviews
Search United Airlines flights
DeltaPriceFrom $539Free CancellationRating
7.9
7,977 reviews
Search Delta flights
LATAM AirlinesPriceFrom $555Free CancellationRating
7.5
1,870 reviews
Search LATAM Airlines flights
Air CanadaPriceFrom $744Free CancellationRating
7.1
10,340 reviews
Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to South America?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to South America. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Columbus with this policy.

How can momondo help me find flights from Columbus to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Columbus to South America.

I’m not ready to book a flight from Columbus to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Columbus are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South America trip

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Fri 11/21
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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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