What airlines fly to South America?

American Airlines, Delta and LATAM Airlines are the top three most popular airlines that fly to South America from Jacksonville according to our data. American Airlines is the first choice among our users, with 76% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Jacksonville to South America?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Jacksonville to South America

When did momondo last update prices for flights from Jacksonville Airport to South America?

Prices for flights from Jacksonville Airport to South America were last updated today.

How many operators does momondo search for flights from Jacksonville Airport to South America?

As of April 2026, there are 3 operators available to choose from for flights from Jacksonville Airport to South America.

How old do you have to be to fly from Jacksonville Airport to South America?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Jacksonville Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$156 Cheap Flights from Jacksonville to South America in 2026

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Jacksonville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:05 am - 1:15 pm

JAX

CTG

6h 10m

1 stop

2:13 pm - 12:22 am

CTG

JAX

9h 09m

1 stop

$353Delta

Sat, May 9 - Tue, May 12

6:00 am - 2:04 pm

JAX

CTG

9h 04m

1 stop

1:25 pm - 9:03 am

CTG

JAX

18h 38m

2 stops

$358American Airlines

Sat, May 9 - Tue, May 12

7:05 am - 11:35 pm

JAX

CTG

17h 30m

2 stops

4:25 am - 12:23 am

CTG

JAX

18h 58m

2 stops

$364LATAM Airlines

Fri, May 8 - Mon, May 11

7:44 pm - 2:04 pm

JAX

CTG

19h 20m

1 stop

1:25 pm - 9:03 am

CTG

JAX

18h 38m

2 stops

$365American Airlines

Thu, May 7 - Sun, May 10

7:05 am - 1:15 pm

JAX

CTG

7h 10m

1 stop

2:13 pm - 8:41 am

CTG

JAX

17h 28m

1 stop

$373LATAM Airlines

Sat, May 9 - Tue, May 12

7:20 am - 9:10 pm

JAX

MDE

38h 50m

2 stops

9:45 am - 10:19 am

MDE

JAX

23h 34m

2 stops

$386United Airlines

Thu, Jun 18 - Tue, Jun 30

6:35 am - 9:10 pm

JAX

MDE

15h 35m

1 stop

9:45 am - 8:02 pm

MDE

JAX

9h 17m

1 stop

$387United Airlines

Wed, Apr 29 - Wed, May 6

6:00 am - 5:50 pm

JAX

BOG

12h 50m

2 stops

8:40 am - 12:23 am

BOG

JAX

14h 43m

2 stops

$521Delta

Thu, May 28 - Thu, Jun 4

7:05 am - 4:05 am

JAX

GIG

20h 00m

2 stops

5:10 am - 10:16 am

GIG

JAX

30h 06m

2 stops

$1,167Copa Airlines

Tue, Sep 8 - Sun, Sep 13

6:35 am - 12:30 am

JAX

GRU

16h 55m

2 stops

1:30 am - 9:46 pm

GRU

JAX

21h 16m

2 stops

$1,226Copa Airlines

Sun, May 3 - Sat, May 9

American Airlines flights from Jacksonville to South America

Our best American Airlines deals on Jacksonville to South America flight tickets

American Airlines

May 9

JAX6:12 pmJacksonville

18h 57m

2 stops

CTG12:09 pmCartagena Rafael Nunez

May 12

CTG1:25 pmCartagena Rafael Nunez

18h 38m

2 stops

JAX9:03 amJacksonville

$358

American Airlines

May 7

JAX7:44 pmJacksonville

19h 20m

1 stop

CTG2:04 pmCartagena Rafael Nunez

May 10

CTG1:25 pmCartagena Rafael Nunez

18h 38m

2 stops

JAX9:03 amJacksonville

$365

American Airlines

May 3

JAX6:00 amJacksonville

15h 15m

1 stop

MDE8:15 pmMedellín Jose Maria Cordova Intl

May 6

MDE6:00 amMedellín Jose Maria Cordova Intl

16h 59m

1 stop

JAX11:59 pmJacksonville

$367

Delta flights from Jacksonville to South America

Our best Delta deals on Jacksonville to South America flight tickets

Delta

May 9

JAX8:05 amJacksonville

6h 10m

1 stop

CTG1:15 pmCartagena Rafael Nunez

May 12

CTG2:13 pmCartagena Rafael Nunez

9h 09m

1 stop

JAX12:22 amJacksonville

$353

Delta

Apr 29

JAX5:30 amJacksonville

18h 00m

2 stops

MDE10:30 pmMedellín Jose Maria Cordova Intl

May 7

MDE6:20 amMedellín Jose Maria Cordova Intl

14h 21m

2 stops

JAX9:41 pmJacksonville

$428

Delta

Apr 28

JAX6:59 pmJacksonville

28h 31m

2 stops

MDE10:30 pmMedellín Jose Maria Cordova Intl

May 4

MDE5:05 amMedellín Jose Maria Cordova Intl

12h 49m

2 stops

JAX6:54 pmJacksonville

$435

momondo Fare Finder

Use the filters below to find and compare flights from Jacksonville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Sat 5/9

8:05 am-1:15 pm

1 stop6h 10m

Cartagena Rafael Nunez

Tue 5/12

2:13 pm-12:22 am

1 stop9h 09m

$353

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Sat 5/9

6:00 am-2:04 pm

1 stop9h 04m

Cartagena Rafael Nunez

Tue 5/12

1:25 pm-9:03 am

2 stops18h 38m

$358

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Fri 5/8

7:05 am-11:35 pm

2 stops17h 30m

Cartagena Rafael Nunez

Mon 5/11

4:25 am-12:23 am

2 stops18h 58m

$364

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Thu 5/7

7:44 pm-2:04 pm

1 stop19h 20m

Cartagena Rafael Nunez

Sun 5/10

1:25 pm-9:03 am

2 stops18h 38m

$365

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Sat 5/9

7:05 am-1:15 pm

1 stop7h 10m

Cartagena Rafael Nunez

Tue 5/12

2:13 pm-8:41 am

1 stop17h 28m

$373

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Thu 6/18

7:20 am-9:10 pm

2 stops38h 50m

Medellín Jose Maria Cordova Intl

Tue 6/30

9:45 am-10:19 am

2 stops23h 34m

$386

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Wed 4/29

6:35 am-9:10 pm

1 stop15h 35m

Medellín Jose Maria Cordova Intl

Wed 5/6

9:45 am-8:02 pm

1 stop9h 17m

$387

JacksonvilleBogotá

JAX - BOG

JAXBOG

Jacksonville

Thu 5/28

6:00 am-5:50 pm

2 stops12h 50m

Bogotá El Dorado

Thu 6/4

8:40 am-12:23 am

2 stops14h 43m

$521

JacksonvilleRio de Janeiro

JAX - GIG

JAXGIG

Jacksonville

Tue 9/8

7:05 am-4:05 am

2 stops20h 00m

Rio de Janeiro–Galeão Intl

Sun 9/13

5:10 am-10:16 am

2 stops30h 06m

$1,167

JacksonvilleSao Paulo

JAX - GRU

JAXGRU

Jacksonville

Sun 5/3

6:35 am-12:30 am

2 stops16h 55m

Sao Paulo Guarulhos Intl

Sat 5/9

1:30 am-9:46 pm

2 stops21h 16m

$1,226

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Jacksonville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Jacksonville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $653. If you aren’t able to travel during the month of September, then book flights to South America from Jacksonville during February instead. Flights to South America in February, while not as cheap as those in September, still average around $661.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Jacksonville when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $756 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Jacksonville for as low as $570 on momondo.

Can stopping save me money on Jacksonville to South America flights?

You could potentially save up to 28% on your flight if you consider stops on a Jacksonville to South America flight.

Cheap Jacksonville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Jacksonville to South America

Fastest flight time	5h 23m
Direct flights	None

The fastest flight from Jacksonville to South America takes 5h 23m

There are no direct flights from Jacksonville to South America. There are no popular flight routes from Jacksonville to South America.

Search flight deals

Frequently asked questions about flying from Jacksonville to South America

When did momondo last update prices for flights from Jacksonville Airport to South America?
Prices for flights from Jacksonville Airport to South America were last updated today.
How many operators does momondo search for flights from Jacksonville Airport to South America?
As of April 2026, there are 3 operators available to choose from for flights from Jacksonville Airport to South America.
How old do you have to be to fly from Jacksonville Airport to South America?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Jacksonville Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Jacksonville to South America

Compare and see reviews for airlines that fly from Jacksonville to South America with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $407	Free Cancellation	Rating 7.1 11,562 reviews	Search American Airlines flights
Delta	PriceFrom $425	Free Cancellation	Rating 7.9 8,394 reviews	Search Delta flights
LATAM Airlines	PriceFrom $590	Free Cancellation	Rating 7.4 1,909 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Jacksonville to South America?

Finding the right flight to South America from Jacksonville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Jacksonville to South America with flexible booking policies on momondo?

Yes. All flights to South America from Jacksonville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Jacksonville to South America?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South America from Jacksonville.

I’m not ready to book a flight from Jacksonville to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Jacksonville to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.