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Cheap flights from Ithaca to Knoxville from $429

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Ithaca to Knoxville departing on 4/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Ithaca to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 10:50 am
ITH
-
TYS
4h 50m
1 stop
United Airlines Logo
7:18 pm - 11:44 pm
TYS
-
ITH
4h 26m
1 stop
$459United Airlines
mar., avr. 28 - sam., mai 2
United Airlines Logo
6:00 am - 10:50 am
ITH
-
TYS
4h 50m
1 stop
United Airlines Logo
1:52 pm - 11:44 pm
TYS
-
ITH
9h 52m
2 stops
$464United Airlines
mar., avr. 28 - sam., mai 2
United Airlines Logo
6:00 am - 5:01 pm
ITH
-
TYS
11h 01m
2 stops
United Airlines Logo
1:52 pm - 11:44 pm
TYS
-
ITH
9h 52m
2 stops
$575United Airlines
mar., avr. 28 - sam., mai 2
United Airlines Logo
10:30 am - 3:09 pm
ITH
-
TYS
4h 39m
1 stop
United Airlines Logo
5:55 pm - 11:44 pm
TYS
-
ITH
29h 49m
2 stops
$612United Airlines
lun., avr. 27 - ven., mai 1
Delta Logo
5:40 am - 9:48 pm
ITH
-
TYS
16h 08m
2 stops
Delta Logo
3:30 pm - 12:51 pm
TYS
-
ITH
21h 21m
2 stops
$637Delta
mar., mai 19 - jeu., mai 28
Delta Logo
5:31 am - 2:33 pm
ITH
-
TYS
9h 02m
2 stops
Delta Logo
3:54 pm - 12:09 am
TYS
-
ITH
8h 15m
2 stops
$641Delta
ven., juin 5 - lun., juin 8
United Airlines Logo
10:30 am - 3:09 pm
ITH
-
TYS
4h 39m
1 stop
United Airlines Logo
7:18 pm - 9:48 am
TYS
-
ITH
14h 30m
1 stop
$658United Airlines
lun., avr. 27 - ven., mai 1
Delta Logo
5:40 am - 9:25 pm
ITH
-
TYS
15h 45m
2 stops
Delta Logo
11:44 am - 12:51 pm
TYS
-
ITH
25h 07m
2 stops
$676Delta
mer., mai 20 - ven., mai 29
Delta Logo
5:40 am - 8:28 pm
ITH
-
TYS
14h 48m
2 stops
Delta Logo
5:40 am - 11:46 pm
TYS
-
ITH
18h 06m
2 stops
$687Delta
mar., mai 19 - mar., mai 26
United Airlines Logo
6:10 am - 10:49 am
ITH
-
TYS
4h 39m
1 stop
United Airlines Logo
7:18 pm - 11:44 pm
TYS
-
ITH
4h 26m
1 stop
$695United Airlines
mar., mai 12 - mar., mai 19

United Airlines flights from Ithaca to Knoxville

Our best United Airlines deals on Ithaca to Knoxville flight tickets
United Airlines
Apr 28
ITH6:00 amIthaca Tompkins County
4h 50m
1 stop
TYS10:50 amKnoxville McGhee Tyson
May 2
TYS7:18 pmKnoxville McGhee Tyson
4h 26m
1 stop
ITH11:44 pmIthaca Tompkins County
$459
United Airlines
Apr 28
ITH6:00 amIthaca Tompkins County
4h 50m
1 stop
TYS10:50 amKnoxville McGhee Tyson
May 2
TYS1:52 pmKnoxville McGhee Tyson
9h 52m
2 stops
ITH11:44 pmIthaca Tompkins County
$464
United Airlines
Apr 21
ITH6:00 amIthaca Tompkins County
4h 50m
1 stop
TYS10:50 amKnoxville McGhee Tyson
Apr 25
TYS2:25 pmKnoxville McGhee Tyson
4h 24m
1 stop
ITH6:49 pmIthaca Tompkins County
$499

Delta flights from Ithaca to Knoxville

Our best Delta deals on Ithaca to Knoxville flight tickets
Delta
May 19
ITH5:40 amIthaca Tompkins County
16h 08m
2 stops
TYS9:48 pmKnoxville McGhee Tyson
May 28
TYS3:30 pmKnoxville McGhee Tyson
21h 21m
2 stops
ITH12:51 pmIthaca Tompkins County
$637
Delta
Jun 5
ITH5:31 amIthaca Tompkins County
9h 02m
2 stops
TYS2:33 pmKnoxville McGhee Tyson
Jun 8
TYS3:54 pmKnoxville McGhee Tyson
8h 15m
2 stops
ITH12:09 amIthaca Tompkins County
$641
Delta
May 20
ITH5:40 amIthaca Tompkins County
15h 45m
2 stops
TYS9:25 pmKnoxville McGhee Tyson
May 29
TYS11:44 amKnoxville McGhee Tyson
25h 07m
2 stops
ITH12:51 pmIthaca Tompkins County
$676

momondo Fare Finder

 
Customize your flight search to find flights from Ithaca to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated avril 16, 2026.
Use the filters below to find and compare flights from Ithaca to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mar. 4/28

6:00 am-10:50 am

1 stop4h 50m

Knoxville McGhee Tyson

sam. 5/2

7:18 pm-11:44 pm

1 stop4h 26m

$459

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mar. 4/28

6:00 am-10:50 am

1 stop4h 50m

Knoxville McGhee Tyson

sam. 5/2

1:52 pm-11:44 pm

2 stops9h 52m

$464

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mar. 4/28

6:00 am-5:01 pm

2 stops11h 01m

Knoxville McGhee Tyson

sam. 5/2

1:52 pm-11:44 pm

2 stops9h 52m

$575

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

lun. 4/27

10:30 am-3:09 pm

1 stop4h 39m

Knoxville McGhee Tyson

ven. 5/1

5:55 pm-11:44 pm

2 stops29h 49m

$612

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mar. 5/19

5:40 am-9:48 pm

2 stops16h 08m

Knoxville McGhee Tyson

jeu. 5/28

3:30 pm-12:51 pm

2 stops21h 21m

$637

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

ven. 6/5

5:31 am-2:33 pm

2 stops9h 02m

Knoxville McGhee Tyson

lun. 6/8

3:54 pm-12:09 am

2 stops8h 15m

$641

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

lun. 4/27

10:30 am-3:09 pm

1 stop4h 39m

Knoxville McGhee Tyson

ven. 5/1

7:18 pm-9:48 am

1 stop14h 30m

$658

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mer. 5/20

5:40 am-9:25 pm

2 stops15h 45m

Knoxville McGhee Tyson

ven. 5/29

11:44 am-12:51 pm

2 stops25h 07m

$676

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mar. 5/19

5:40 am-8:28 pm

2 stops14h 48m

Knoxville McGhee Tyson

mar. 5/26

5:40 am-11:46 pm

2 stops18h 06m

$687
Quickest round-trip

IthacaKnoxville

ITH - TYS

ITHTYS

Ithaca Tompkins County

mar. 5/12

6:10 am-10:49 am

1 stop4h 39m

Knoxville McGhee Tyson

mar. 5/19

7:18 pm-11:44 pm

1 stop4h 26m

$695

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Ithaca to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Ithaca Tompkins County to Knoxville McGhee Tyson?

United Airlines and Delta are the most popular carriers operating from Ithaca Tompkins County to Knoxville McGhee Tyson

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Ithaca according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When to book flights from Ithaca to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Ithaca to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Ithaca to Knoxville (ITH to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ithaca to Knoxville

Fastest flight time

4h 07m

Direct flights

None
The fastest flight from Ithaca to Knoxville takes 4h 07m
There are no direct flights from Ithaca to Knoxville. There are no popular flight routes from Ithaca to Knoxville.
Search flight deals

Frequently asked questions about flying from Ithaca to Knoxville

  • How far is Ithaca Tompkins County to Knoxville McGhee Tyson by plane?

    Ithaca Tompkins County and Knoxville McGhee Tyson are 597.8 mi apart from one another. Typically, this will take 4h 07m by plane in normal conditions.

  • When did momondo last update prices for flights from Ithaca Tompkins County Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Ithaca Tompkins County Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How old do you have to be to fly from Ithaca Tompkins County Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Ithaca Tompkins County Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Ithaca to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Ithaca to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Ithaca to Knoxville with flexible booking policies on momondo?

Flights from Ithaca to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Ithaca to Knoxville?

momondo helps you find the best flight between Ithaca and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Ithaca to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Ithaca and alert you when they change.

An easier way to manage your Knoxville trip

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sam. 5/16
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