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Cheap flights from Harlingen, Texas to Des Moines from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harlingen, Texas to Des Moines departing on 12/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Harlingen, Texas to Des Moines

Cheap round-trip flights

American Airlines Logo
6:37 pm - 11:16 pmHRL-DSM
4h 39m1 stop
American Airlines Logo
5:04 am - 9:36 amDSM-HRL
4h 32m1 stop
$257American Airlines
Find Deal
Wed, Oct 22 - Mon, Oct 27
Delta Logo
3:39 pm - 9:03 pmHRL-DSM
5h 24m1 stop
Delta Logo
7:03 am - 2:43 pmDSM-HRL
7h 40m1 stop
$263Delta
Find Deal
Wed, Oct 22 - Sat, Oct 25
American Airlines Logo
5:34 am - 10:47 amHRL-DSM
5h 13m1 stop
American Airlines Logo
5:01 am - 9:50 amDSM-HRL
4h 49m1 stop
$295American Airlines
Find Deal
Tue, Dec 23 - Tue, Jan 6
American Airlines Logo
6:37 pm - 11:16 pmHRL-DSM
4h 39m1 stop
American Airlines Logo
5:00 am - 9:36 amDSM-HRL
4h 36m1 stop
$297American Airlines
Find Deal
Wed, Oct 22 - Sun, Oct 26
American Airlines Logo
5:34 am - 10:47 amHRL-DSM
5h 13m1 stop
American Airlines Logo
6:57 am - 4:17 pmDSM-HRL
9h 20m2 stops
$315American Airlines
Find Deal
Tue, Dec 23 - Tue, Jan 6
American Airlines Logo
6:37 pm - 11:16 pmHRL-DSM
4h 39m1 stop
American Airlines Logo
1:48 pm - 12:02 amDSM-HRL
10h 14m2 stops
$317American Airlines
Find Deal
Wed, Oct 22 - Mon, Oct 27
United Airlines Logo
5:00 am - 2:23 pmHRL-DSM
9h 23m2 stops
United Airlines Logo
6:05 am - 10:59 amDSM-HRL
4h 54m1 stop
$336United Airlines
Find Deal
Wed, Oct 22 - Sun, Oct 26
United Airlines Logo
5:00 am - 2:23 pmHRL-DSM
9h 23m2 stops
United Airlines Logo
11:31 am - 7:41 pmDSM-HRL
8h 10m2 stops
$387United Airlines
Find Deal
Wed, Oct 22 - Sat, Oct 25
United Airlines Logo
5:00 am - 2:23 pmHRL-DSM
9h 23m2 stops
United Airlines Logo
6:05 am - 10:59 amDSM-HRL
4h 54m1 stop
$406United Airlines
Find Deal
Wed, Oct 22 - Sun, Oct 26
Southwest Logo
10:40 am - 9:50 pmHRL-DSM
11h 10m2 stops
Southwest Logo
6:00 am - 12:55 pmDSM-HRL
6h 55m2 stops
$465Southwest
Find Deal
Wed, Oct 22 - Sun, Oct 26

American Airlines flights from Harlingen, Texas to Des Moines

Our best American Airlines deals on Harlingen, Texas to Des Moines flight tickets
American Airlines
Oct 22
HRL6:37 pmHarlingen Valley Intl
4h 39m
1 stop
DSM11:16 pmDes Moines
Oct 27
DSM5:04 amDes Moines
4h 32m
1 stop
HRL9:36 amHarlingen Valley Intl
$257
Find similar
American Airlines
Dec 23
HRL5:34 amHarlingen Valley Intl
5h 13m
1 stop
DSM10:47 amDes Moines
Jan 6
DSM5:01 amDes Moines
4h 49m
1 stop
HRL9:50 amHarlingen Valley Intl
$295
Find similar
American Airlines
Oct 22
HRL6:37 pmHarlingen Valley Intl
4h 39m
1 stop
DSM11:16 pmDes Moines
Oct 26
DSM5:00 amDes Moines
4h 36m
1 stop
HRL9:36 amHarlingen Valley Intl
$297
Find similar

United Airlines flights from Harlingen, Texas to Des Moines

Our best United Airlines deals on Harlingen, Texas to Des Moines flight tickets
United Airlines
Oct 22
HRL5:00 amHarlingen Valley Intl
9h 23m
2 stops
DSM2:23 pmDes Moines
Oct 26
DSM6:05 amDes Moines
4h 54m
1 stop
HRL10:59 amHarlingen Valley Intl
$336
Find similar
United Airlines
Sep 13
HRL2:05 pmHarlingen Valley Intl
9h 36m
2 stops
DSM11:41 pmDes Moines
Sep 20
DSM6:15 amDes Moines
7h 15m
1 stop
HRL1:30 pmHarlingen Valley Intl
$348
Find similar
United Airlines
Sep 13
HRL2:05 pmHarlingen Valley Intl
9h 36m
2 stops
DSM11:41 pmDes Moines
Sep 20
DSM11:35 amDes Moines
7h 58m
2 stops
HRL7:33 pmHarlingen Valley Intl
$353
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Harlingen, Texas to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Harlingen, Texas to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

6:37 pm-11:16 pm

1 stop4h 39m

Des Moines

Mon 10/27

5:04 am-9:36 am

1 stop4h 32m

$257

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

3:39 pm-9:03 pm

1 stop5h 24m

Des Moines

Sat 10/25

7:03 am-2:43 pm

1 stop7h 40m

$263

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Tue 12/23

5:34 am-10:47 am

1 stop5h 13m

Des Moines

Tue 1/6

5:01 am-9:50 am

1 stop4h 49m

$295

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

6:37 pm-11:16 pm

1 stop4h 39m

Des Moines

Sun 10/26

5:00 am-9:36 am

1 stop4h 36m

$297

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Tue 12/23

5:34 am-10:47 am

1 stop5h 13m

Des Moines

Tue 1/6

6:57 am-4:17 pm

2 stops9h 20m

$315

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

6:37 pm-11:16 pm

1 stop4h 39m

Des Moines

Mon 10/27

1:48 pm-12:02 am

2 stops10h 14m

$317

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

5:00 am-2:23 pm

2 stops9h 23m

Des Moines

Sun 10/26

6:05 am-10:59 am

1 stop4h 54m

$336

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

5:00 am-2:23 pm

2 stops9h 23m

Des Moines

Sat 10/25

11:31 am-7:41 pm

2 stops8h 10m

$387

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

5:00 am-2:23 pm

2 stops9h 23m

Des Moines

Sun 10/26

6:05 am-10:59 am

1 stop4h 54m

$406

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 10/22

10:40 am-9:50 pm

2 stops11h 10m

Des Moines

Sun 10/26

6:00 am-12:55 pm

2 stops6h 55m

$465

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Harlingen, Texas to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Harlingen, Texas to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $368. Flights from Harlingen, Texas to Des Moines on a Friday will generally be more expensive and average around $510. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Harlingen, Texas to Des Moines in the morning for as low as $367. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $498. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Harlingen, Texas to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Harlingen, Texas to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harlingen, Texas to Des Moines (HRL to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harlingen, Texas to Des Moines

Direct flights

None
There are no direct flights from Harlingen, Texas to Des Moines. There are no popular flight routes from Harlingen, Texas to Des Moines.
Search flight deals

  • How far is Harlingen Valley Intl to Des Moines by plane?

    The distance between Harlingen Valley Intl and Des Moines is about 1087.9 mi. 4h 39m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Harlingen Valley Intl Airport to Des Moines Airport?

    Prices for flights from Harlingen Valley Intl Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Harlingen Valley Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Harlingen Valley Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harlingen Valley Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Harlingen, Texas to Des Moines?

Best airlines flying from Harlingen, Texas to Des Moines

Compare and see reviews for airlines that fly from Harlingen, Texas to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Harlingen to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Harlingen to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Harlingen to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Harlingen to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Harlingen to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Harlingen.

I’m not ready to book a flight from Harlingen to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Harlingen and alert you when they change.

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