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Cheap flights from Harlingen, Texas to Des Moines from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harlingen, Texas to Des Moines departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Harlingen, Texas to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 10:34 am
HRL
-
DSM
4h 34m
1 stop
American Airlines Logo
6:08 pm - 11:03 pm
DSM
-
HRL
4h 55m
1 stop
$323American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
8:06 pm - 9:01 am
HRL
-
DSM
12h 55m
2 stops
American Airlines Logo
6:08 pm - 11:03 pm
DSM
-
HRL
4h 55m
1 stop
$382American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
6:00 am - 10:34 am
HRL
-
DSM
4h 34m
1 stop
American Airlines Logo
5:00 am - 10:12 am
DSM
-
HRL
5h 12m
1 stop
$404American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
6:00 am - 10:34 am
HRL
-
DSM
4h 34m
1 stop
American Airlines Logo
3:26 pm - 10:53 pm
DSM
-
HRL
7h 27m
1 stop
$405American Airlines
Thu, Feb 26 - Sun, Mar 1
American Airlines Logo
6:00 am - 10:34 am
HRL
-
DSM
4h 34m
1 stop
American Airlines Logo
7:44 pm - 10:12 am
DSM
-
HRL
14h 28m
2 stops
$426American Airlines
Thu, Feb 26 - Sun, Mar 1
American Airlines Logo
6:00 am - 10:34 am
HRL
-
DSM
4h 34m
1 stop
American Airlines Logo
6:08 pm - 11:03 pm
DSM
-
HRL
4h 55m
1 stop
$449American Airlines
Fri, Feb 20 - Sat, Feb 21
American Airlines Logo
2:45 pm - 11:40 pm
HRL
-
DSM
8h 55m
2 stops
American Airlines Logo
6:08 pm - 11:03 pm
DSM
-
HRL
4h 55m
1 stop
$454American Airlines
Fri, Feb 20 - Sat, Feb 21
American Airlines Logo
2:45 pm - 11:40 pm
HRL
-
DSM
8h 55m
2 stops
American Airlines Logo
5:00 am - 10:12 am
DSM
-
HRL
5h 12m
1 stop
$455American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
6:00 am - 10:34 am
HRL
-
DSM
4h 34m
1 stop
American Airlines Logo
6:08 pm - 11:03 pm
DSM
-
HRL
4h 55m
1 stop
$460American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
2:45 pm - 11:40 pm
HRL
-
DSM
8h 55m
2 stops
American Airlines Logo
5:00 am - 2:14 pm
DSM
-
HRL
9h 14m
2 stops
$485American Airlines
Fri, Feb 20 - Sat, Feb 21

United Airlines flights from Harlingen, Texas to Des Moines

Our best United Airlines deals on Harlingen, Texas to Des Moines flight tickets
United Airlines
Feb 14
HRL9:20 amHarlingen Valley Intl
4h 57m
1 stop
DSM2:17 pmDes Moines
Feb 18
DSM2:59 pmDes Moines
20h 25m
1 stop
HRL11:24 amHarlingen Valley Intl
$520
United Airlines
Feb 14
HRL7:00 amHarlingen Valley Intl
10h 47m
2 stops
DSM5:47 pmDes Moines
Feb 18
DSM2:59 pmDes Moines
25h 05m
1 stop
HRL4:04 pmHarlingen Valley Intl
$525
United Airlines
Mar 4
HRL9:20 amHarlingen Valley Intl
10h 52m
2 stops
DSM8:12 pmDes Moines
Mar 11
DSM2:59 pmDes Moines
6h 57m
1 stop
HRL9:56 pmHarlingen Valley Intl
$526

American Airlines flights from Harlingen, Texas to Des Moines

Our best American Airlines deals on Harlingen, Texas to Des Moines flight tickets
American Airlines
Feb 26
HRL6:00 amHarlingen Valley Intl
4h 34m
1 stop
DSM10:34 amDes Moines
Mar 2
DSM6:08 pmDes Moines
4h 55m
1 stop
HRL11:03 pmHarlingen Valley Intl
$323
American Airlines
Feb 26
HRL8:06 pmHarlingen Valley Intl
12h 55m
2 stops
DSM9:01 amDes Moines
Mar 2
DSM6:08 pmDes Moines
4h 55m
1 stop
HRL11:03 pmHarlingen Valley Intl
$382
American Airlines
Feb 18
HRL6:00 amHarlingen Valley Intl
4h 34m
1 stop
DSM10:34 amDes Moines
Feb 22
DSM5:00 amDes Moines
5h 12m
1 stop
HRL10:12 amHarlingen Valley Intl
$404

momondo Fare Finder

 
Customize your flight search to find flights from Harlingen, Texas to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from Harlingen, Texas to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Thu 2/26

6:00 am-10:34 am

1 stop4h 34m

Des Moines

Mon 3/2

6:08 pm-11:03 pm

1 stop4h 55m

$323

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Thu 2/26

8:06 pm-9:01 am

2 stops12h 55m

Des Moines

Mon 3/2

6:08 pm-11:03 pm

1 stop4h 55m

$382

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 2/18

6:00 am-10:34 am

1 stop4h 34m

Des Moines

Sun 2/22

5:00 am-10:12 am

1 stop5h 12m

$404

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Thu 2/26

6:00 am-10:34 am

1 stop4h 34m

Des Moines

Sun 3/1

3:26 pm-10:53 pm

1 stop7h 27m

$405

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Thu 2/26

6:00 am-10:34 am

1 stop4h 34m

Des Moines

Sun 3/1

7:44 pm-10:12 am

2 stops14h 28m

$426

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Fri 2/20

6:00 am-10:34 am

1 stop4h 34m

Des Moines

Sat 2/21

6:08 pm-11:03 pm

1 stop4h 55m

$449

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Fri 2/20

2:45 pm-11:40 pm

2 stops8h 55m

Des Moines

Sat 2/21

6:08 pm-11:03 pm

1 stop4h 55m

$454

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Wed 2/18

2:45 pm-11:40 pm

2 stops8h 55m

Des Moines

Sun 2/22

5:00 am-10:12 am

1 stop5h 12m

$455

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Fri 2/20

6:00 am-10:34 am

1 stop4h 34m

Des Moines

Tue 2/24

6:08 pm-11:03 pm

1 stop4h 55m

$460

HarlingenDes Moines

HRL - DSM

HRLDSM

Harlingen Valley Intl

Fri 2/20

2:45 pm-11:40 pm

2 stops8h 55m

Des Moines

Sat 2/21

5:00 am-2:14 pm

2 stops9h 14m

$485

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Harlingen, Texas to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Harlingen Valley Intl to Des Moines?

American Airlines is the most popular carrier operating from Harlingen Valley Intl to Des Moines

When to book flights from Harlingen, Texas to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Harlingen, Texas to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harlingen, Texas to Des Moines (HRL to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harlingen, Texas to Des Moines

Fastest flight time

4h 58m

Direct flights

None
The fastest flight from Harlingen, Texas to Des Moines takes 4h 58m
There are no direct flights from Harlingen, Texas to Des Moines. There are no popular flight routes from Harlingen, Texas to Des Moines.
Search flight deals

  • How far is Harlingen Valley Intl to Des Moines by plane?

    The distance between Harlingen Valley Intl and Des Moines is about 1087.9 mi. 4h 58m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Harlingen Valley Intl Airport to Des Moines Airport?

    Prices for flights from Harlingen Valley Intl Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Harlingen Valley Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Harlingen Valley Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harlingen Valley Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Harlingen, Texas to Des Moines?

Best airlines flying from Harlingen, Texas to Des Moines

Compare and see reviews for airlines that fly from Harlingen, Texas to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $334Free CancellationRating
7.2
11,243 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Harlingen to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Harlingen to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Harlingen to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Harlingen to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Harlingen to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Harlingen.

I’m not ready to book a flight from Harlingen to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Harlingen and alert you when they change.

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