What airlines fly to Des Moines?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Des Moines from Greenville according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Greenville Airport to Des Moines Airport?

Prices for flights from Greenville Airport to Des Moines Airport were last updated today.

How many operators does momondo search for flights from Greenville Airport to Des Moines Airport?

The number of operators available for flights from Greenville Airport to Des Moines Airport is 3 as of October 2025.

How old do you have to be to fly from Greenville Airport to Des Moines Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$160 Cheap Flights from Greenville to Des Moines in 2025/26

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Find the cheapest flights from Greenville to Des Moines

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Cheap round-trip flights

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10:07 am - 1:32 pmGSP-DSM

4h 25m1 stop

10:21 am - 5:35 pmDSM-GSP

6h 14m1 stop

$315Delta

Find Deal

Wed, Nov 12 - Sat, Nov 15

4:17 pm - 11:44 pmGSP-DSM

8h 27m1 stop

1:05 pm - 11:56 pmDSM-GSP

9h 51m2 stops

$320United Airlines

Find Deal

Wed, Nov 12 - Sat, Nov 15

6:00 am - 2:19 pmGSP-DSM

9h 19m2 stops

1:05 pm - 11:56 pmDSM-GSP

9h 51m2 stops

$325United Airlines

Find Deal

Wed, Nov 12 - Sat, Nov 15

3:37 pm - 8:44 amGSP-DSM

18h 07m1 stop

6:50 pm - 2:47 pmDSM-GSP

18h 57m1 stop

$345Allegiant Air

Find Deal

Thu, Oct 23 - Sat, Oct 25

3:50 pm - 9:01 amGSP-DSM

18h 11m1 stop

8:00 am - 9:20 pmDSM-GSP

12h 20m1 stop

$348Allegiant Air

Find Deal

Wed, Nov 26 - Mon, Dec 1

6:35 am - 10:05 amGSP-DSM

4h 30m1 stop

7:20 am - 2:30 pmDSM-GSP

6h 10m1 stop

$360Delta

Find Deal

Thu, Oct 30 - Sun, Nov 2

6:00 am - 10:47 amGSP-DSM

5h 47m1 stop

3:28 pm - 11:52 pmDSM-GSP

7h 24m1 stop

$409American Airlines

Find Deal

Wed, Dec 24 - Sat, Jan 3

6:00 am - 10:47 amGSP-DSM

5h 47m1 stop

1:25 pm - 11:58 pmDSM-GSP

9h 33m2 stops

$414American Airlines

Find Deal

Wed, Dec 24 - Sat, Jan 3

1:50 pm - 11:30 pmGSP-DSM

10h 40m2 stops

7:25 am - 6:15 pmDSM-GSP

9h 50m2 stops

$463Southwest

Find Deal

Thu, Oct 23 - Sat, Oct 25

4:20 pm - 12:05 amGSP-DSM

8h 45m2 stops

5:40 am - 7:25 pmDSM-GSP

12h 45m2 stops

$665Southwest

Find Deal

Wed, Nov 26 - Sat, Nov 29

United Airlines flights from Greenville to Des Moines

Our best United Airlines deals on Greenville to Des Moines flight tickets

United Airlines

Nov 12

GSP4:17 pmGreenville

8h 27m

1 stop

DSM11:44 pmDes Moines

Nov 15

DSM1:05 pmDes Moines

9h 51m

2 stops

GSP11:56 pmGreenville

$320

Find similar

United Airlines

Nov 12

GSP6:00 amGreenville

9h 19m

2 stops

DSM2:19 pmDes Moines

Nov 15

DSM1:05 pmDes Moines

9h 51m

2 stops

GSP11:56 pmGreenville

$325

Find similar

United Airlines

Oct 23

GSP9:35 amGreenville

5h 48m

1 stop

DSM2:23 pmDes Moines

Oct 28

DSM1:05 pmDes Moines

9h 51m

2 stops

GSP11:56 pmGreenville

$385

Find similar

American Airlines flights from Greenville to Des Moines

Our best American Airlines deals on Greenville to Des Moines flight tickets

American Airlines

Dec 24

GSP6:00 amGreenville

5h 47m

1 stop

DSM10:47 amDes Moines

Jan 3

DSM3:28 pmDes Moines

7h 24m

1 stop

GSP11:52 pmGreenville

$409

Find similar

American Airlines

Dec 24

GSP6:00 amGreenville

5h 47m

1 stop

DSM10:47 amDes Moines

Jan 3

DSM1:25 pmDes Moines

9h 33m

2 stops

GSP11:58 pmGreenville

$414

Find similar

American Airlines

Oct 30

GSP6:00 amGreenville

8h 18m

2 stops

DSM1:18 pmDes Moines

Nov 2

DSM5:26 pmDes Moines

5h 29m

1 stop

GSP11:55 pmGreenville

$435

Find similar

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 11/12

10:07 am-1:32 pm

1 stop4h 25m

Des Moines

Sat 11/15

10:21 am-5:35 pm

1 stop6h 14m

$315

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 11/12

4:17 pm-11:44 pm

1 stop8h 27m

Des Moines

Sat 11/15

1:05 pm-11:56 pm

2 stops9h 51m

$320

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 11/12

6:00 am-2:19 pm

2 stops9h 19m

Des Moines

Sat 11/15

1:05 pm-11:56 pm

2 stops9h 51m

$325

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 10/23

3:37 pm-8:44 am

1 stop18h 07m

Des Moines

Sat 10/25

6:50 pm-2:47 pm

1 stop18h 57m

$345

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 11/26

3:50 pm-9:01 am

1 stop18h 11m

Des Moines

Mon 12/1

8:00 am-9:20 pm

1 stop12h 20m

$348

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 10/30

6:35 am-10:05 am

1 stop4h 30m

Des Moines

Sun 11/2

7:20 am-2:30 pm

1 stop6h 10m

$360

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 12/24

6:00 am-10:47 am

1 stop5h 47m

Des Moines

Sat 1/3

3:28 pm-11:52 pm

1 stop7h 24m

$409

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 12/24

6:00 am-10:47 am

1 stop5h 47m

Des Moines

Sat 1/3

1:25 pm-11:58 pm

2 stops9h 33m

$414

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 10/23

1:50 pm-11:30 pm

2 stops10h 40m

Des Moines

Sat 10/25

7:25 am-6:15 pm

2 stops9h 50m

$463

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 11/26

4:20 pm-12:05 am

2 stops8h 45m

Des Moines

Sat 11/29

5:40 am-7:25 pm

2 stops12h 45m

$665

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Greenville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in March, then October is your next best option. Flight prices from Greenville to Des Moines during October average around $337.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Greenville to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $327. Flights from Greenville to Des Moines on a Monday will generally be more expensive and average around $673. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Greenville to Des Moines at noon for as low as $336. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $543. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Greenville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Greenville to Des Moines (GSP to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Des Moines

Direct flights	None

There are no direct flights from Greenville to Des Moines. There are no popular flight routes from Greenville to Des Moines.

Search flight deals

How far is Greenville to Des Moines by plane?
Des Moines is 765.4 mi away from Greenville. In terms of flight time, this usually takes a little over 4h 25m.
When did momondo last update prices for flights from Greenville Airport to Des Moines Airport?
Prices for flights from Greenville Airport to Des Moines Airport were last updated today.
How many operators does momondo search for flights from Greenville Airport to Des Moines Airport?
The number of operators available for flights from Greenville Airport to Des Moines Airport is 3 as of October 2025.
How old do you have to be to fly from Greenville Airport to Des Moines Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Greenville to Des Moines?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Greenville to Des Moines is American Airlines (49% of total bookings). The next most popular airlines are Delta (41%) and United Airlines (10%).

Best airlines flying from Greenville to Des Moines

Compare and see reviews for airlines that fly from Greenville to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $216	Free Cancellation	Rating 7.9 7,969 reviews	Search Delta flights
American Airlines	PriceFrom $256	Free Cancellation	Rating 7.2 11,043 reviews	Search American Airlines flights
United Airlines	PriceFrom $326	Free Cancellation	Rating 7.4 8,968 reviews	Search United Airlines flights

West Des Moines

Ames

Ankeny

Altoona

Clive

Urbandale

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Greenville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Greenville to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Greenville.

I’m not ready to book a flight from Greenville to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.