What airlines fly to Des Moines?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Des Moines from Greenville according to our data. American Airlines is the first choice among our users, with 72% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Greenville to Des Moines?

American Airlines, Southwest, and Delta are the most popular carriers operating from Greenville to Des Moines

When did momondo last update prices for flights from Greenville Airport to Des Moines Airport?

Prices for flights from Greenville Airport to Des Moines Airport were last updated today.

How many operators does momondo search for flights from Greenville Airport to Des Moines Airport?

The number of operators available for flights from Greenville Airport to Des Moines Airport is 3 as of August 2025.

How old do you have to be to fly from Greenville Airport to Des Moines Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$105 Cheap Flights from Greenville to Des Moines (GSP-DSM) in 2025

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Find the cheapest flights from Greenville to Des Moines (GSP-DSM)

Round-trip

One-way

Cheap round-trip flights

6:11 am - 12:19 pmGSP-DSM

7h 08m1 stop

1:48 pm - 7:34 pmDSM-GSP

4h 46m1 stop

$223American Airlines

Find Deal

mar., oct. 7 - sáb., oct. 11

5:30 am - 10:05 amGSP-DSM

5h 35m1 stop

3:15 pm - 10:06 pmDSM-GSP

5h 51m1 stop

$234Delta

Find Deal

mié., oct. 8 - vie., oct. 10

11:48 am - 7:20 pmGSP-DSM

8h 32m1 stop

6:39 pm - 11:54 pmDSM-GSP

4h 15m1 stop

$244Delta

Find Deal

jue., oct. 30 - dom., nov. 2

2:37 pm - 8:11 pmGSP-DSM

6h 34m2 stops

5:42 pm - 10:52 pmDSM-GSP

4h 10m1 stop

$264American Airlines

Find Deal

sáb., oct. 11 - mar., oct. 14

5:34 pm - 9:50 pmGSP-DSM

5h 16m1 stop

12:52 pm - 11:46 pmDSM-GSP

9h 54m2 stops

$298United Airlines

Find Deal

mar., oct. 7 - sáb., oct. 11

9:35 am - 8:18 pmGSP-DSM

11h 43m2 stops

11:31 am - 11:46 pmDSM-GSP

11h 15m2 stops

$303United Airlines

Find Deal

mar., oct. 7 - sáb., oct. 11

7:38 pm - 11:06 pmGSP-DSM

4h 28m1 stop

12:49 pm - 8:43 pmDSM-GSP

6h 54m1 stop

$305American Airlines

Find Deal

vie., oct. 3 - vie., oct. 10

11:22 am - 3:18 pmGSP-DSM

4h 56m1 stop

5:10 am - 11:46 amDSM-GSP

5h 36m1 stop

$332American Airlines

Find Deal

mar., sep. 2 - jue., sep. 4

1:50 pm - 11:30 pmGSP-DSM

10h 40m2 stops

6:35 am - 9:25 pmDSM-GSP

13h 50m2 stops

$375Southwest

Find Deal

vie., oct. 3 - vie., oct. 10

1:50 pm - 11:30 pmGSP-DSM

10h 40m2 stops

6:20 am - 7:55 pmDSM-GSP

12h 35m2 stops

$385Southwest

Find Deal

vie., oct. 10 - mar., oct. 14

American Airlines flights from Greenville to Des Moines

Our best American Airlines deals on Greenville to Des Moines flight tickets

American Airlines

Oct 7

GSP6:11 amGreenville

7h 08m

1 stop

DSM12:19 pmDes Moines

Oct 11

DSM1:48 pmDes Moines

4h 46m

1 stop

GSP7:34 pmGreenville

$223

Find similar

American Airlines

Oct 11

GSP2:37 pmGreenville

6h 34m

2 stops

DSM8:11 pmDes Moines

Oct 14

DSM5:42 pmDes Moines

4h 10m

1 stop

GSP10:52 pmGreenville

$264

Find similar

American Airlines

Oct 3

GSP7:38 pmGreenville

4h 28m

1 stop

DSM11:06 pmDes Moines

Oct 10

DSM12:49 pmDes Moines

6h 54m

1 stop

GSP8:43 pmGreenville

$305

Find similar

Delta flights from Greenville to Des Moines

Our best Delta deals on Greenville to Des Moines flight tickets

Delta

Oct 8

GSP5:30 amGreenville

5h 35m

1 stop

DSM10:05 amDes Moines

Oct 10

DSM3:15 pmDes Moines

5h 51m

1 stop

GSP10:06 pmGreenville

$234

Find similar

Delta

Oct 30

GSP11:48 amGreenville

8h 32m

1 stop

DSM7:20 pmDes Moines

Nov 2

DSM6:39 pmDes Moines

4h 15m

1 stop

GSP11:54 pmGreenville

$244

Find similar

Delta

Oct 8

GSP6:35 amGreenville

4h 30m

1 stop

DSM10:05 amDes Moines

Oct 10

DSM3:15 pmDes Moines

5h 51m

1 stop

GSP10:06 pmGreenville

$354

Find similar

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 10/7

6:11 am-12:19 pm

1 stop7h 08m

Des Moines

sáb. 10/11

1:48 pm-7:34 pm

1 stop4h 46m

$223

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mié. 10/8

5:30 am-10:05 am

1 stop5h 35m

Des Moines

vie. 10/10

3:15 pm-10:06 pm

1 stop5h 51m

$234

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jue. 10/30

11:48 am-7:20 pm

1 stop8h 32m

Des Moines

dom. 11/2

6:39 pm-11:54 pm

1 stop4h 15m

$244

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

sáb. 10/11

2:37 pm-8:11 pm

2 stops6h 34m

Des Moines

mar. 10/14

5:42 pm-10:52 pm

1 stop4h 10m

$264

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 10/7

5:34 pm-9:50 pm

1 stop5h 16m

Des Moines

sáb. 10/11

12:52 pm-11:46 pm

2 stops9h 54m

$298

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 10/7

9:35 am-8:18 pm

2 stops11h 43m

Des Moines

sáb. 10/11

11:31 am-11:46 pm

2 stops11h 15m

$303

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

vie. 10/3

7:38 pm-11:06 pm

1 stop4h 28m

Des Moines

vie. 10/10

12:49 pm-8:43 pm

1 stop6h 54m

$305

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 9/2

11:22 am-3:18 pm

1 stop4h 56m

Des Moines

jue. 9/4

5:10 am-11:46 am

1 stop5h 36m

$332

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

vie. 10/3

1:50 pm-11:30 pm

2 stops10h 40m

Des Moines

vie. 10/10

6:35 am-9:25 pm

2 stops13h 50m

$375

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

vie. 10/10

1:50 pm-11:30 pm

2 stops10h 40m

Des Moines

mar. 10/14

6:20 am-7:55 pm

2 stops12h 35m

$385

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from Greenville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then March is your next best option. Flight prices from Greenville to Des Moines during March average around $319.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Greenville to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $327. Flights from Greenville to Des Moines on a Monday will generally be more expensive and average around $673. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Greenville to Des Moines at noon for as low as $336. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $543. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Greenville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Greenville to Des Moines (GSP to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Des Moines

Best Price Found	$105
Fastest flight time	4h 28m
Direct flights	None
Airports in Des Moines	1 airport

The best one-way flight to Des Moines from Greenville in the past 72 hours is $105. The best round-trip flight deal from Greenville to Des Moines found on momondo in the last 72 hours is $223.

The fastest flight from Greenville to Des Moines takes 4h 28m

There are no direct flights from Greenville to Des Moines. Popular non-direct route for this connection is Greenville Airport - Des Moines Airport.

There is 1 airport near Des Moines: Des Moines (DSM)

Search flight deals

How far is Greenville to Des Moines by plane?
Des Moines is 765.4 mi away from Greenville. In terms of flight time, this usually takes a little over 4h 28m.
When did momondo last update prices for flights from Greenville Airport to Des Moines Airport?
Prices for flights from Greenville Airport to Des Moines Airport were last updated today.
How many operators does momondo search for flights from Greenville Airport to Des Moines Airport?
The number of operators available for flights from Greenville Airport to Des Moines Airport is 3 as of August 2025.
How old do you have to be to fly from Greenville Airport to Des Moines Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Greenville to Des Moines?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Greenville to Des Moines is American Airlines (51% of total bookings). The next most popular airlines are Delta (38%) and United Airlines (11%).

Best airlines flying from Greenville to Des Moines

Compare and see reviews for airlines that fly from Greenville to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $216	Free Cancellation	Rating 8.0 7,980 reviews	Search Delta flights
American Airlines	PriceFrom $266	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $366	Free Cancellation	Rating 7.4 8,916 reviews	Search United Airlines flights

West Des Moines

Ames

Ankeny

Altoona

Clive

Urbandale

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Greenville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Greenville to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Greenville.

I’m not ready to book a flight from Greenville to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.