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Cheap flights from Greenville to Des Moines from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Des Moines departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Greenville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:40 pm - 9:18 pm
GSP
-
DSM
4h 38m
1 stop
United Airlines Logo
11:40 am - 4:59 pm
DSM
-
GSP
4h 19m
1 stop
$285United Airlines
Tue, May 5 - Tue, May 12
United Airlines Logo
6:00 am - 2:24 pm
GSP
-
DSM
9h 24m
2 stops
United Airlines Logo
6:15 am - 2:10 pm
DSM
-
GSP
6h 55m
1 stop
$290United Airlines
Tue, May 5 - Tue, May 12
Southwest Logo
1:55 pm - 10:10 pm
GSP
-
DSM
9h 15m
2 stops
Southwest Logo
5:30 am - 4:20 pm
DSM
-
GSP
9h 50m
2 stops
$297Southwest
Tue, May 5 - Tue, May 12
American Airlines Logo
7:30 am - 11:30 am
GSP
-
DSM
5h 00m
1 stop
American Airlines Logo
2:16 pm - 7:46 pm
DSM
-
GSP
4h 30m
1 stop
$301American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
5:20 am - 1:46 pm
GSP
-
DSM
9h 26m
2 stops
American Airlines Logo
11:09 am - 7:46 pm
DSM
-
GSP
7h 37m
1 stop
$306American Airlines
Sat, May 9 - Tue, May 12
Delta Logo
8:45 am - 1:37 pm
GSP
-
DSM
5h 52m
1 stop
Delta Logo
2:33 pm - 8:13 pm
DSM
-
GSP
4h 40m
1 stop
$317Delta
Sat, May 9 - Tue, May 12
Delta Logo
5:40 am - 11:05 am
GSP
-
DSM
6h 25m
1 stop
Delta Logo
2:44 pm - 10:13 pm
DSM
-
GSP
6h 29m
1 stop
$318Delta
Sat, Apr 18 - Mon, Apr 27
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
American Airlines Logo
7:25 am - 1:14 pm
DSM
-
GSP
4h 49m
1 stop
$322American Airlines
Sat, May 9 - Tue, May 12
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
American Airlines Logo
3:00 pm - 8:01 pm
DSM
-
GSP
4h 01m
1 stop
$323American Airlines
Sat, Apr 18 - Mon, Apr 27
American Airlines Logo
5:20 am - 1:46 pm
GSP
-
DSM
9h 26m
2 stops
American Airlines Logo
8:56 am - 4:50 pm
DSM
-
GSP
6h 54m
2 stops
$327American Airlines
Sat, May 9 - Tue, May 12

Southwest flights from Greenville to Des Moines

Our best Southwest deals on Greenville to Des Moines flight tickets
Southwest
May 5
GSP1:55 pmGreenville
9h 15m
2 stops
DSM10:10 pmDes Moines
May 12
DSM5:30 amDes Moines
9h 50m
2 stops
GSP4:20 pmGreenville
$297
Southwest
Aug 15
GSP6:45 amGreenville
8h 25m
2 stops
DSM2:10 pmDes Moines
Aug 18
DSM7:15 amDes Moines
8h 30m
2 stops
GSP4:45 pmGreenville
$397
Southwest
Apr 2
GSP6:25 amGreenville
6h 45m
2 stops
DSM12:10 pmDes Moines
Apr 5
DSM5:25 amDes Moines
5h 30m
2 stops
GSP11:55 amGreenville
$410

Delta flights from Greenville to Des Moines

Our best Delta deals on Greenville to Des Moines flight tickets
Delta
May 9
GSP8:45 amGreenville
5h 52m
1 stop
DSM1:37 pmDes Moines
May 12
DSM2:33 pmDes Moines
4h 40m
1 stop
GSP8:13 pmGreenville
$317
Delta
Apr 18
GSP5:40 amGreenville
6h 25m
1 stop
DSM11:05 amDes Moines
Apr 27
DSM2:44 pmDes Moines
6h 29m
1 stop
GSP10:13 pmGreenville
$318
Delta
Apr 18
GSP6:51 amGreenville
5h 14m
1 stop
DSM11:05 amDes Moines
Apr 27
DSM2:44 pmDes Moines
6h 29m
1 stop
GSP10:13 pmGreenville
$336

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 3, 2026.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

5:40 pm-9:18 pm

1 stop4h 38m

Des Moines

Tue 5/12

11:40 am-4:59 pm

1 stop4h 19m

$285

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

6:00 am-2:24 pm

2 stops9h 24m

Des Moines

Tue 5/12

6:15 am-2:10 pm

1 stop6h 55m

$290

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

1:55 pm-10:10 pm

2 stops9h 15m

Des Moines

Tue 5/12

5:30 am-4:20 pm

2 stops9h 50m

$297

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

7:30 am-11:30 am

1 stop5h 00m

Des Moines

Tue 5/12

2:16 pm-7:46 pm

1 stop4h 30m

$301

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

5:20 am-1:46 pm

2 stops9h 26m

Des Moines

Tue 5/12

11:09 am-7:46 pm

1 stop7h 37m

$306

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

8:45 am-1:37 pm

1 stop5h 52m

Des Moines

Tue 5/12

2:33 pm-8:13 pm

1 stop4h 40m

$317

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 4/18

5:40 am-11:05 am

1 stop6h 25m

Des Moines

Mon 4/27

2:44 pm-10:13 pm

1 stop6h 29m

$318

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

7:02 am-1:46 pm

2 stops7h 44m

Des Moines

Tue 5/12

7:25 am-1:14 pm

1 stop4h 49m

$322

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 4/18

7:02 am-1:46 pm

2 stops7h 44m

Des Moines

Mon 4/27

3:00 pm-8:01 pm

1 stop4h 01m

$323

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

5:20 am-1:46 pm

2 stops9h 26m

Des Moines

Tue 5/12

8:56 am-4:50 pm

2 stops6h 54m

$327

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Greenville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then September is your next best option. Flight prices from Greenville to Des Moines during September average around $338.

When to book flights from Greenville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Des Moines (GSP to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Des Moines

Fastest flight time

4h 42m

Direct flights

None
The fastest flight from Greenville to Des Moines takes 4h 42m
There are no direct flights from Greenville to Des Moines. There are no popular flight routes from Greenville to Des Moines.
Search flight deals

  • How far is Greenville to Des Moines by plane?

    Des Moines is 765.4 mi away from Greenville. In terms of flight time, this usually takes a little over 4h 42m.

  • When did momondo last update prices for flights from Greenville Airport to Des Moines Airport?

    Prices for flights from Greenville Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to Des Moines Airport?

  • How old do you have to be to fly from Greenville Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Des Moines?

Best airlines flying from Greenville to Des Moines

Compare and see reviews for airlines that fly from Greenville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
8,242 reviews
Search Delta flights
American AirlinesPriceFrom $216Free CancellationRating
7.1
11,375 reviews
Search American Airlines flights
United AirlinesPriceFrom $326Free CancellationRating
7.4
9,377 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Greenville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Greenville to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Greenville.

I’m not ready to book a flight from Greenville to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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