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Cheap flights from Detroit Metropolitan Wayne County Airport to Knoxville from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Knoxville departing on 11/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:15 am - 6:12 pmDTW-TYS
11h 57m1 stop
Multiple Airlines Logo
4:24 pm - 10:13 amTYS-DTW
17h 49m1 stop
$175Multiple Airlines
Find Deal
Wed, Dec 17 - Fri, Dec 19
Multiple Airlines Logo
10:08 pm - 12:05 pmDTW-TYS
13h 57m1 stop
Multiple Airlines Logo
1:39 pm - 7:42 amTYS-DTW
18h 03m1 stop
$183Multiple Airlines
Find Deal
Thu, Feb 5 - Sun, Feb 8
Multiple Airlines Logo
7:14 pm - 12:05 pmDTW-TYS
16h 51m2 stops
Multiple Airlines Logo
1:39 pm - 7:42 amTYS-DTW
18h 03m1 stop
$209Multiple Airlines
Find Deal
Thu, Feb 5 - Sun, Feb 8
Multiple Airlines Logo
6:15 am - 6:12 pmDTW-TYS
11h 57m1 stop
Multiple Airlines Logo
2:53 pm - 1:19 amTYS-DTW
10h 26m1 stop
$214Multiple Airlines
Find Deal
Wed, Dec 17 - Sat, Dec 20
Multiple Airlines Logo
6:15 am - 6:12 pmDTW-TYS
11h 57m1 stop
Multiple Airlines Logo
9:25 pm - 3:47 pmTYS-DTW
18h 22m2 stops
$236Multiple Airlines
Find Deal
Wed, Dec 17 - Fri, Dec 19
Multiple Airlines Logo
6:25 am - 8:35 pmDTW-TYS
14h 10m1 stop
Multiple Airlines Logo
5:42 pm - 8:42 amTYS-DTW
15h 00m1 stop
$246Multiple Airlines
Find Deal
Fri, Dec 19 - Sun, Dec 21
Multiple Airlines Logo
6:38 pm - 12:03 pmDTW-TYS
17h 25m1 stop
Multiple Airlines Logo
12:45 pm - 1:19 amTYS-DTW
12h 34m1 stop
$248Multiple Airlines
Find Deal
Tue, Dec 2 - Fri, Dec 5
Multiple Airlines Logo
2:50 pm - 8:18 amDTW-TYS
17h 28m2 stops
Multiple Airlines Logo
5:23 pm - 1:24 pmTYS-DTW
20h 01m1 stop
$249Multiple Airlines
Find Deal
Wed, Dec 17 - Sat, Dec 20
Multiple Airlines Logo
5:15 am - 5:53 pmDTW-TYS
12h 38m2 stops
Multiple Airlines Logo
3:32 pm - 11:25 amTYS-DTW
19h 53m1 stop
$251Multiple Airlines
Find Deal
Thu, Jan 8 - Sun, Jan 11
Multiple Airlines Logo
10:28 am - 12:57 pmDTW-TYS
26h 29m1 stop
Multiple Airlines Logo
12:45 pm - 1:19 amTYS-DTW
12h 34m1 stop
$254Multiple Airlines
Find Deal
Tue, Dec 2 - Fri, Dec 5

American Airlines flights from Detroit Metropolitan Wayne County Airport to Knoxville

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Knoxville flight tickets
American Airlines
Dec 9
DTW1:39 pmDetroit Metropolitan Wayne County
8h 01m
1 stop
TYS9:40 pmKnoxville McGhee Tyson
Dec 16
TYS8:06 amKnoxville McGhee Tyson
10h 09m
1 stop
DTW6:15 pmDetroit Metropolitan Wayne County
$295
Find similar
American Airlines
Dec 13
DTW7:12 amDetroit Metropolitan Wayne County
7h 17m
1 stop
TYS2:29 pmKnoxville McGhee Tyson
Dec 16
TYS8:06 amKnoxville McGhee Tyson
10h 09m
1 stop
DTW6:15 pmDetroit Metropolitan Wayne County
$307
Find similar
American Airlines
Jan 15
DTW10:46 amDetroit Metropolitan Wayne County
5h 10m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
Jan 19
TYS7:44 amKnoxville McGhee Tyson
7h 47m
1 stop
DTW3:31 pmDetroit Metropolitan Wayne County
$319
Find similar

Delta flights from Detroit Metropolitan Wayne County Airport to Knoxville

Our best Delta deals on Detroit Metropolitan Wayne County Airport to Knoxville flight tickets
Delta
Dec 13
DTW6:20 pmDetroit Metropolitan Wayne County
1h 40m
TYS8:00 pmKnoxville McGhee Tyson
Dec 20
TYS7:30 amKnoxville McGhee Tyson
1h 50m
DTW9:20 amDetroit Metropolitan Wayne County
$299
Find similar
Delta
Dec 13
DTW12:22 pmDetroit Metropolitan Wayne County
4h 27m
1 stop
TYS4:49 pmKnoxville McGhee Tyson
Dec 20
TYS7:30 amKnoxville McGhee Tyson
1h 50m
DTW9:20 amDetroit Metropolitan Wayne County
$309
Find similar
Delta
Dec 7
DTW10:06 amDetroit Metropolitan Wayne County
1h 41m
TYS11:47 amKnoxville McGhee Tyson
Dec 14
TYS5:40 amKnoxville McGhee Tyson
5h 21m
1 stop
DTW11:01 amDetroit Metropolitan Wayne County
$329
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 12/17

6:15 am-6:12 pm

1 stop11h 57m

Knoxville McGhee Tyson

Fri 12/19

4:24 pm-10:13 am

1 stop17h 49m

$175

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 2/5

10:08 pm-12:05 pm

1 stop13h 57m

Knoxville McGhee Tyson

Sun 2/8

1:39 pm-7:42 am

1 stop18h 03m

$183

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 2/5

7:14 pm-12:05 pm

2 stops16h 51m

Knoxville McGhee Tyson

Sun 2/8

1:39 pm-7:42 am

1 stop18h 03m

$209

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 12/17

6:15 am-6:12 pm

1 stop11h 57m

Knoxville McGhee Tyson

Sat 12/20

2:53 pm-1:19 am

1 stop10h 26m

$214

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 12/17

6:15 am-6:12 pm

1 stop11h 57m

Knoxville McGhee Tyson

Fri 12/19

9:25 pm-3:47 pm

2 stops18h 22m

$236

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Fri 12/19

6:25 am-8:35 pm

1 stop14h 10m

Knoxville McGhee Tyson

Sun 12/21

5:42 pm-8:42 am

1 stop15h 00m

$246

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 12/2

6:38 pm-12:03 pm

1 stop17h 25m

Knoxville McGhee Tyson

Fri 12/5

12:45 pm-1:19 am

1 stop12h 34m

$248

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Wed 12/17

2:50 pm-8:18 am

2 stops17h 28m

Knoxville McGhee Tyson

Sat 12/20

5:23 pm-1:24 pm

1 stop20h 01m

$249

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Thu 1/8

5:15 am-5:53 pm

2 stops12h 38m

Knoxville McGhee Tyson

Sun 1/11

3:32 pm-11:25 am

1 stop19h 53m

$251

DetroitKnoxville

DTW - TYS

DTWTYS

Detroit Metropolitan Wayne County

Tue 12/2

10:28 am-12:57 pm

1 stop26h 29m

Knoxville McGhee Tyson

Fri 12/5

12:45 pm-1:19 am

1 stop12h 34m

$254

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Detroit Metropolitan Wayne County Airport, with most prices found around $381. If you aren’t able to travel during the month of January, then book flights to Knoxville from Detroit Metropolitan Wayne County Airport during October instead. Flights to Knoxville in October, while not as cheap as those in January, still average around $394.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Detroit Metropolitan Wayne County Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $399. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Detroit Metropolitan Wayne County Airport to Knoxville for around $497.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Detroit Metropolitan Wayne County Airport to Knoxville when you can find flight prices for as low as $419. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $477.

What is the cheapest Detroit Metropolitan Wayne County to Knoxville McGhee Tyson flight route?

Fly from Detroit Metropolitan Wayne County to Knoxville McGhee Tyson for the best Detroit Metropolitan Wayne County - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $441 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Detroit Metropolitan Wayne County Airport for as low as $349 on momondo.

What cabin class options are available on Detroit Metropolitan Wayne County to Knoxville McGhee Tyson flights?

There are 3 cabin classes available to choose from on Detroit Metropolitan Wayne County to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Knoxville flights?

You could potentially save up to 31% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Knoxville flight.

How have Detroit Metropolitan Wayne County Airport to Knoxville flight prices changed over time?

When to book flights from Detroit Metropolitan Wayne County Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Knoxville (DTW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Knoxville

Best Price Found

$278

Fastest flight time

1h 33m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $278. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Knoxville found on momondo in the last 72 hours is $359.
The fastest flight from Detroit Metropolitan Wayne County Airport to Knoxville takes 1h 33m
Direct flights go from Detroit Metropolitan Wayne County Airport to Knoxville every day.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Knoxville McGhee Tyson by plane?

    There are 433.4 mi between Detroit Metropolitan Wayne County and Knoxville McGhee Tyson. Flights usually cover this in 1h 40m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Knoxville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Knoxville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Knoxville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $216Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
DeltaPriceFrom $311Free CancellationRating
7.9
8,007 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Knoxville

    Delta flies from Detroit Metropolitan Wayne County Airport to Knoxville around 13 times per week, with 8,007 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Knoxville in the last 72 hours was $311 (round-trip), much lower than the average airfare cost of $454 for Delta flights on this route.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Detroit.

Can I find flights from Detroit to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Detroit on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Detroit to Knoxville?

Once all potential Detroit to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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