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Cheap flights from Des Moines to Chicago from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Chicago departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

American Airlines Logo
5:00 am - 6:28 amDSM-ORD
1h 28mnonstop
American Airlines Logo
7:00 am - 8:25 amORD-DSM
1h 25mnonstop
$189American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
2:21 pm - 3:58 pmDSM-ORD
1h 37mnonstop
American Airlines Logo
10:00 pm - 11:23 pmORD-DSM
1h 23mnonstop
$190American Airlines
Find Deal
Thu, Oct 2 - Thu, Oct 9
American Airlines Logo
5:00 am - 6:28 amDSM-ORD
1h 28mnonstop
American Airlines Logo
7:00 am - 8:25 amORD-DSM
1h 25mnonstop
$191American Airlines
Find Deal
Thu, Sep 11 - Sun, Sep 14
Logo
10:41 am - 10:48 pmDSM-ORD
12h 07m1 stop
Logo
1:26 pm - 7:57 pmORD-DSM
6h 31m1 stop
$196
Find Deal
Thu, Oct 2 - Thu, Oct 9
Delta Logo
5:25 pm - 9:21 pmDSM-ORD
3h 56m1 stop
Delta Logo
8:57 am - 1:59 pmORD-DSM
5h 02m1 stop
$197Delta
Find Deal
Tue, Sep 30 - Tue, Oct 7
Frontier Logo
2:25 pm - 11:59 pmDSM-ORD
9h 34m1 stop
Frontier Logo
6:00 am - 1:40 pmORD-DSM
7h 40m1 stop
$198Frontier
Find Deal
Fri, Sep 26 - Sun, Sep 28
Frontier Logo
2:25 pm - 11:59 pmDSM-ORD
9h 34m1 stop
Frontier Logo
6:00 am - 1:40 pmORD-DSM
7h 40m1 stop
$202Frontier
Find Deal
Fri, Sep 26 - Sun, Sep 28
Delta Logo
6:00 am - 10:19 amDSM-ORD
4h 19m1 stop
Delta Logo
6:15 am - 10:14 amORD-DSM
3h 59m1 stop
$203Delta
Find Deal
Wed, Sep 17 - Thu, Sep 18
Logo
5:51 pm - 11:41 pmDSM-ORD
5h 50m1 stop
Logo
7:29 pm - 9:51 amORD-DSM
14h 22m1 stop
$216
Find Deal
Mon, Oct 13 - Wed, Oct 15
United Airlines Logo
11:35 am - 1:09 pmDSM-ORD
1h 34mnonstop
United Airlines Logo
9:12 am - 10:39 amORD-DSM
1h 27mnonstop
$250United Airlines
Find Deal
Thu, Sep 11 - Sun, Sep 14

Frontier flights from Des Moines to Chicago O'Hare Intl Airport

Our best Frontier deals on Des Moines to Chicago O'Hare Intl Airport flight tickets
Frontier
Sep 26
DSM2:25 pmDes Moines
9h 34m
1 stop
ORD11:59 pmChicago O'Hare Intl
Sep 28
ORD6:00 amChicago O'Hare Intl
7h 40m
1 stop
DSM1:40 pmDes Moines
$198
Find similar
Frontier
Sep 26
DSM2:25 pmDes Moines
9h 34m
1 stop
ORD11:59 pmChicago O'Hare Intl
Sep 28
ORD6:00 amChicago O'Hare Intl
7h 40m
1 stop
DSM1:40 pmDes Moines
$202
Find similar
Frontier
Sep 5
DSM2:25 pmDes Moines
9h 34m
1 stop
ORD11:59 pmChicago O'Hare Intl
Sep 7
ORD8:49 pmChicago O'Hare Intl
16h 51m
2 stops
DSM1:40 pmDes Moines
$206
Find similar

Delta flights from Des Moines to Chicago O'Hare Intl Airport

Our best Delta deals on Des Moines to Chicago O'Hare Intl Airport flight tickets
Delta
Sep 30
DSM5:25 pmDes Moines
3h 56m
1 stop
ORD9:21 pmChicago O'Hare Intl
Oct 7
ORD8:57 amChicago O'Hare Intl
5h 02m
1 stop
DSM1:59 pmDes Moines
$197
Find similar
Delta
Sep 17
DSM6:00 amDes Moines
4h 19m
1 stop
ORD10:19 amChicago O'Hare Intl
Sep 18
ORD6:15 amChicago O'Hare Intl
3h 59m
1 stop
DSM10:14 amDes Moines
$203
Find similar
Delta
Sep 6
DSM12:35 pmDes Moines
3h 38m
1 stop
ORD4:13 pmChicago O'Hare Intl
Sep 7
ORD6:10 amChicago O'Hare Intl
3h 57m
1 stop
DSM10:07 amDes Moines
$209
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Des Moines to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 9/26

5:00 am-6:28 am

Nonstop1h 28m

Chicago O'Hare Intl

Sun 9/28

7:00 am-8:25 am

Nonstop1h 25m

$189

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 10/2

2:21 pm-3:58 pm

Nonstop1h 37m

Chicago O'Hare Intl

Thu 10/9

10:00 pm-11:23 pm

Nonstop1h 23m

$190

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 9/11

5:00 am-6:28 am

Nonstop1h 28m

Chicago O'Hare Intl

Sun 9/14

7:00 am-8:25 am

Nonstop1h 25m

$191

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 10/2

10:41 am-10:48 pm

1 stop12h 07m

Chicago O'Hare Intl

Thu 10/9

1:26 pm-7:57 pm

1 stop6h 31m

$196

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 9/30

5:25 pm-9:21 pm

1 stop3h 56m

Chicago O'Hare Intl

Tue 10/7

8:57 am-1:59 pm

1 stop5h 02m

$197

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 9/26

2:25 pm-11:59 pm

1 stop9h 34m

Chicago O'Hare Intl

Sun 9/28

6:00 am-1:40 pm

1 stop7h 40m

$198

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 9/26

2:25 pm-11:59 pm

1 stop9h 34m

Chicago O'Hare Intl

Sun 9/28

6:00 am-1:40 pm

1 stop7h 40m

$202

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 9/17

6:00 am-10:19 am

1 stop4h 19m

Chicago O'Hare Intl

Thu 9/18

6:15 am-10:14 am

1 stop3h 59m

$203

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Mon 10/13

5:51 pm-11:41 pm

1 stop5h 50m

Chicago O'Hare Intl

Wed 10/15

7:29 pm-9:51 am

1 stop14h 22m

$216

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 9/11

11:35 am-1:09 pm

Nonstop1h 34m

Chicago O'Hare Intl

Sun 9/14

9:12 am-10:39 am

Nonstop1h 27m

$250

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Des Moines to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of March is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Des Moines averaging around $249.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Thursday when prices can be found for as low as $569. This is often the case because there is less demand to fly during this day of the week. On the other hand, Tuesday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $870.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Des Moines in the evening is the least expensive time of day to depart. momondo users have found prices as low as $249 when looking at flights departing in the evening. Try not to purchase tickets at noon because they tend to be around $1,116. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Des Moines to Chicago O'Hare Intl flight route?

Fly from Des Moines to Chicago O'Hare Intl for the best Des Moines - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $256 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Des Moines for as low as $196 on momondo.

What cabin class options are available on Des Moines to Chicago O'Hare Intl flights?

There are 4 cabin classes available to choose from on Des Moines to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Chicago O'Hare Intl Airport flights?

You could potentially save up to 10% on your flight if you consider stops on a Des Moines to Chicago O'Hare Intl Airport flight.

How have Des Moines to Chicago O'Hare Intl Airport flight prices changed over time?

As of August 2025, prices for Des Moines to Chicago O'Hare Intl Airport flights are approximately 51% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Chicago O'Hare Intl Airport (DSM to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Chicago O'Hare Intl Airport

Best Price Found

$81

Fastest flight time

1h 23m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Des Moines in the past 72 hours is $81. The best round-trip flight deal from Des Moines to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $189.
The fastest flight from Des Moines to Chicago O'Hare Intl Airport takes 1h 23m
Direct flights go from Des Moines to Chicago O'Hare Intl Airport every day.
Search flight deals

  • How far is Des Moines to Chicago O'Hare Intl by plane?

    Des Moines and Chicago O'Hare Intl are 295.9 mi apart from one another. Flights usually cover this in 1h 23m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The necessary travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Des Moines to Chicago O'Hare Intl Airport?

Best airlines flying from Des Moines to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Des Moines to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $189Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
8,925 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to Chicago O'Hare Intl Airport

    United Airlines operates around 11 flights from Des Moines to Chicago O'Hare Intl Airport every week. The average price of these flights found in the last 72 hours has been $258, but momondo users have found United Airlines deals from Des Moines to Chicago O'Hare Intl Airport from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 8,925 reviews.

  • American Airlines Flights From Des Moines to Chicago O'Hare Intl Airport

    Another popular option for Des Moines to Chicago O'Hare Intl Airport flights is American Airlines (7.2/10, 10,000 ratings). American Airlines flies from Des Moines to Chicago O'Hare Intl Airport around 28 times per week, with deals starting from $189 round-trip and rising to an average price of around $242.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Rockford
South Haven
Schaumburg
Merrillville
Gurnee
Naperville
Rosemont
Kenosha
New Buffalo
Joliet
Oak Brook
Racine
Hammond
Tinley Park
Orland Park
Elgin
Aurora
Janesville
Benton Harbor

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Chicago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Chicago from Des Moines.

Can I find flights from Des Moines to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Des Moines.

I’m not ready to book a flight from Des Moines to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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