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Cheap flights from Des Moines to Chicago from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Chicago departing on 6/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:57 pm - 7:00 pm
DSM
-
ORD
26h 03m
1 stop
Multiple Airlines Logo
1:50 pm - 11:07 pm
ORD
-
DSM
33h 17m
2 stops
$245Multiple Airlines
Sun, Jul 12 - Wed, Jul 15
American Airlines Logo
8:05 pm - 9:46 pm
DSM
-
ORD
1h 41mnonstop
American Airlines Logo
6:00 pm - 7:35 pm
ORD
-
DSM
1h 35mnonstop
$257American Airlines
Tue, Jun 9 - Wed, Jun 10
American Airlines Logo
7:09 pm - 9:06 pm
DSM
-
ORD
1h 57mnonstop
American Airlines Logo
4:30 pm - 6:03 pm
ORD
-
DSM
1h 33mnonstop
$258American Airlines
Wed, Jul 1 - Wed, Jul 8
American Airlines Logo
5:00 am - 6:42 am
DSM
-
ORD
1h 42mnonstop
American Airlines Logo
6:50 am - 8:23 am
ORD
-
DSM
1h 33mnonstop
$259American Airlines
Wed, Jul 1 - Wed, Jul 8
American Airlines Logo
1:51 pm - 3:36 pm
DSM
-
ORD
1h 45mnonstop
American Airlines Logo
8:27 am - 9:56 am
ORD
-
DSM
1h 29mnonstop
$263American Airlines
Thu, Aug 20 - Wed, Sep 2
American Airlines Logo
7:02 pm - 12:39 am
DSM
-
ORD
5h 37m
1 stop
American Airlines Logo
4:30 pm - 6:03 pm
ORD
-
DSM
1h 33mnonstop
$268American Airlines
Wed, Jul 1 - Wed, Jul 8
American Airlines Logo
7:37 pm - 9:37 pm
DSM
-
ORD
2h 00mnonstop
American Airlines Logo
5:40 pm - 7:14 pm
ORD
-
DSM
1h 34mnonstop
$269American Airlines
Thu, Aug 20 - Sat, Aug 22
Delta Logo
10:24 am - 4:30 pm
DSM
-
ORD
6h 06m
1 stop
Delta Logo
6:30 am - 10:13 am
ORD
-
DSM
3h 43m
1 stop
$277Delta
Wed, Jul 1 - Wed, Jul 8
Frontier Logo
2:16 pm - 8:32 pm
DSM
-
ORD
6h 16m
1 stop
Frontier Logo
9:48 pm - 1:31 pm
ORD
-
DSM
15h 43m
1 stop
$278Frontier
Mon, Jun 8 - Tue, Jun 9
Frontier Logo
2:51 pm - 9:35 pm
DSM
-
ORD
6h 44m
1 stop
Frontier Logo
10:40 pm - 1:56 pm
ORD
-
DSM
15h 16m
1 stop
$282Frontier
Fri, Nov 6 - Sun, Nov 8

Frontier flights from Des Moines to Chicago O'Hare Intl Airport

Our best Frontier deals on Des Moines to Chicago O'Hare Intl Airport flight tickets
Frontier
Jun 8
DSM2:16 pmDes Moines
6h 16m
1 stop
ORD8:32 pmChicago O'Hare Intl
Jun 9
ORD9:48 pmChicago O'Hare Intl
15h 43m
1 stop
DSM1:31 pmDes Moines
$278
Frontier
Nov 6
DSM2:51 pmDes Moines
6h 44m
1 stop
ORD9:35 pmChicago O'Hare Intl
Nov 8
ORD10:40 pmChicago O'Hare Intl
15h 16m
1 stop
DSM1:56 pmDes Moines
$282
Frontier
Jun 15
DSM2:26 pmDes Moines
6h 17m
1 stop
ORD8:43 pmChicago O'Hare Intl
Jun 16
ORD9:48 pmChicago O'Hare Intl
15h 43m
1 stop
DSM1:31 pmDes Moines
$321

American Airlines flights from Des Moines to Chicago O'Hare Intl Airport

Our best American Airlines deals on Des Moines to Chicago O'Hare Intl Airport flight tickets
American Airlines
Jun 9
DSM8:05 pmDes Moines
1h 41m
ORD9:46 pmChicago O'Hare Intl
Jun 10
ORD6:00 pmChicago O'Hare Intl
1h 35m
DSM7:35 pmDes Moines
$257
American Airlines
Jul 1
DSM7:09 pmDes Moines
1h 57m
ORD9:06 pmChicago O'Hare Intl
Jul 8
ORD4:30 pmChicago O'Hare Intl
1h 33m
DSM6:03 pmDes Moines
$258
American Airlines
Jul 1
DSM5:00 amDes Moines
1h 42m
ORD6:42 amChicago O'Hare Intl
Jul 8
ORD6:50 amChicago O'Hare Intl
1h 33m
DSM8:23 amDes Moines
$259

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 22, 2026.
Use the filters below to find and compare flights from Des Moines to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sun 7/12

4:57 pm-7:00 pm

1 stop26h 03m

Chicago O'Hare Intl

Wed 7/15

1:50 pm-11:07 pm

2 stops33h 17m

$245

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 6/9

8:05 pm-9:46 pm

Nonstop1h 41m

Chicago O'Hare Intl

Wed 6/10

6:00 pm-7:35 pm

Nonstop1h 35m

$257

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 7/1

7:09 pm-9:06 pm

Nonstop1h 57m

Chicago O'Hare Intl

Wed 7/8

4:30 pm-6:03 pm

Nonstop1h 33m

$258

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 7/1

5:00 am-6:42 am

Nonstop1h 42m

Chicago O'Hare Intl

Wed 7/8

6:50 am-8:23 am

Nonstop1h 33m

$259
Quickest round-trip

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 8/20

1:51 pm-3:36 pm

Nonstop1h 45m

Chicago O'Hare Intl

Wed 9/2

8:27 am-9:56 am

Nonstop1h 29m

$263

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 7/1

7:02 pm-12:39 am

1 stop5h 37m

Chicago O'Hare Intl

Wed 7/8

4:30 pm-6:03 pm

Nonstop1h 33m

$268

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 8/20

7:37 pm-9:37 pm

Nonstop2h 00m

Chicago O'Hare Intl

Sat 8/22

5:40 pm-7:14 pm

Nonstop1h 34m

$269

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 7/1

10:24 am-4:30 pm

1 stop6h 06m

Chicago O'Hare Intl

Wed 7/8

6:30 am-10:13 am

1 stop3h 43m

$277

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Mon 6/8

2:16 pm-8:32 pm

1 stop6h 16m

Chicago O'Hare Intl

Tue 6/9

9:48 pm-1:31 pm

1 stop15h 43m

$278

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 11/6

2:51 pm-9:35 pm

1 stop6h 44m

Chicago O'Hare Intl

Sun 11/8

10:40 pm-1:56 pm

1 stop15h 16m

$282

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Des Moines to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Chicago O'Hare Intl Airport?

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of December is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Des Moines averaging around $235.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $521. This is often the case because there is less demand to fly during this day of the week. On the other hand, Tuesday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $737.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Des Moines in the morning is the least expensive time of day to depart. momondo users have found prices as low as $512 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $961. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Des Moines to Chicago O'Hare Intl flight route?

Fly from Des Moines to Chicago O'Hare Intl for the best Des Moines - Chicago O'Hare Intl flight prices

How far in advance should I book a flight from Des Moines to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $290 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Des Moines for as low as $169 on momondo.

What cabin class options are available on Des Moines to Chicago O'Hare Intl Airport flights?

There are 4 cabin classes available to choose from on Des Moines to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Chicago O'Hare Intl Airport flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Chicago O'Hare Intl Airport.

How have Des Moines to Chicago O'Hare Intl Airport flight prices changed over time?

As of May 2026, prices for Des Moines to Chicago O'Hare Intl Airport flights are approximately 0% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Chicago O'Hare Intl Airport (DSM to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Chicago O'Hare Intl Airport

Best Price Found

$283

Fastest flight time

1h 30m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Des Moines in the past 72 hours is $283. The best round-trip flight deal from Des Moines to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $439.
The fastest flight from Des Moines to Chicago O'Hare Intl Airport takes 1h 30m
Direct flights go from Des Moines to Chicago O'Hare Intl Airport every day.
Search flight deals

Frequently asked questions about flying from Des Moines to Chicago O'Hare Intl Airport

  • How far is Des Moines to Chicago O'Hare Intl by plane?

    Des Moines and Chicago O'Hare Intl are 295.9 mi apart from one another. Flights usually cover this in 1h 30m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The necessary travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Des Moines to Chicago O'Hare Intl Airport?

Best airlines flying from Des Moines to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Des Moines to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $148Free CancellationRating
7.1
11,644 reviews
Search American Airlines flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
9,751 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to Chicago O'Hare Intl Airport

    United Airlines operates around 27 flights from Des Moines to Chicago O'Hare Intl Airport every week. The average price of these flights found in the last 72 hours has been $276, but momondo users have found United Airlines deals from Des Moines to Chicago O'Hare Intl Airport from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 9,751 reviews.

  • American Airlines Flights From Des Moines to Chicago O'Hare Intl Airport

    Another popular option for Des Moines to Chicago O'Hare Intl Airport flights is American Airlines (7.1/10, 11,644 ratings). American Airlines flies from Des Moines to Chicago O'Hare Intl Airport around 34 times per week, with deals starting from $148 round-trip and rising to an average price of around $249.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
South Haven
Schaumburg
Rockford
Merrillville
Gurnee
Rosemont
Naperville
Orland Park
New Buffalo
Oak Brook
Kenosha
Joliet
Aurora
Racine
Janesville
Hammond
Evanston
Elgin
Tinley Park

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Chicago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Chicago from Des Moines.

Can I find flights from Des Moines to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Des Moines.

I’m not ready to book a flight from Des Moines to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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