Cheap flights from Des Moines to Chicago from $104
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Chicago departing on 11/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Not ready to book? to track prices.Delta flights from Des Moines to Chicago O'Hare Intl Airport
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American Airlines flights from Des Moines to Chicago O'Hare Intl Airport
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Fly from
Fly to
Route
Depart
Return
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Fri 11/6
8:30 pm-12:21 am
1 stop27h 51m
Chicago O'Hare Intl
Mon 11/9
6:30 am-7:35 pm
1 stop13h 05m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 11/12
9:50 am-11:29 am
Nonstop1h 39m
Chicago O'Hare Intl
Fri 12/4
8:55 am-10:37 am
Nonstop1h 42m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 10/29
9:26 am-11:10 am
Nonstop1h 44m
Chicago O'Hare Intl
Thu 11/5
7:14 am-8:46 am
Nonstop1h 32m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 11/5
7:26 pm-9:13 pm
Nonstop1h 47m
Chicago O'Hare Intl
Thu 11/12
10:53 pm-12:26 am
Nonstop1h 33m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 11/12
8:00 am-9:40 am
Nonstop1h 40m
Chicago O'Hare Intl
Sat 11/14
8:50 am-10:32 am
Nonstop1h 42m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 12/3
7:31 pm-9:24 pm
Nonstop1h 53m
Chicago O'Hare Intl
Sat 12/5
11:00 pm-12:40 am
Nonstop1h 40m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 11/12
8:00 am-9:40 am
Nonstop1h 40m
Chicago O'Hare Intl
Sat 11/14
8:50 am-10:32 am
Nonstop1h 42m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 10/29
10:57 am-4:40 pm
1 stop5h 43m
Chicago O'Hare Intl
Thu 11/5
6:20 am-10:11 am
1 stop3h 51m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Wed 2/3
10:55 am-4:49 pm
1 stop5h 54m
Chicago O'Hare Intl
Tue 2/9
6:00 am-10:20 am
1 stop4h 20m
Des MoinesChicago
DSM Des Moines - ORD Chicago O'Hare Intl
DSMORD
Des Moines
Thu 10/29
10:57 am-2:36 pm
1 stop3h 39m
Chicago O'Hare Intl
Thu 11/5
6:20 am-10:11 am
1 stop3h 51m
See travel insights to Chicago from
How to get the cheapest flight ticket from Des Moines to Chicago O'Hare Intl Airport
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the typical price of a round-trip flight between Des Moines and Chicago O'Hare Intl Airport?
Prices are currently low for flights on this route.
Typical prices usually range from $264 to $349.The lowest price recently found on this route was $224.
What is the cheapest month to fly to Chicago O'Hare Intl Airport?
The month of December is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Des Moines averaging around $249.
What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?
The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $536. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $733.
What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?
Flying to Chicago O'Hare Intl Airport from Des Moines in the morning is the least expensive time of day to depart. momondo users have found prices as low as $514 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $1,085. Of course, these prices can vary depending on the time of year and what airport you fly to.
What is the cheapest Des Moines to Chicago O'Hare Intl flight route?
Fly from Des Moines to Chicago O'Hare Intl for the best Des Moines - Chicago O'Hare Intl flight prices
How far in advance should I book a flight from Des Moines to Chicago O'Hare Intl Airport?
You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $337 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Des Moines for as low as $199 on momondo.
What cabin class options are available on Des Moines to Chicago O'Hare Intl Airport flights?
There are 4 cabin classes available to choose from on Des Moines to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.
Can stopping save me money on Des Moines to Chicago O'Hare Intl Airport flights?
You could potentially save up to 21% on your flight if you consider stops on a Des Moines to Chicago O'Hare Intl Airport flight.
How have Des Moines to Chicago O'Hare Intl Airport flight prices changed over time?
As of October 2026, prices for Des Moines to Chicago O'Hare Intl Airport flights are approximately 47% more expensive when compared to flights at the same time last year.
How many flights depart from Des Moines to Chicago O'Hare Intl Airport on average per day?
As of October 2026, there are 40 flights per day flying from Des Moines to Chicago O'Hare Intl Airport. The most common time of day flights depart is 3:00PM, with 45% of flights taking off at noon.
How many flights depart from Des Moines to Chicago O'Hare Intl Airport on average per week?
As of October 2026, there are 285 flights per week flying from Des Moines to Chicago O'Hare Intl Airport. The most common day of the week flights depart is Wed, with 16% of flights taking off on this day.
When to book flights from Des Moines to Chicago O'Hare Intl Airport
Cheap Des Moines to Chicago O'Hare Intl Airport (DSM to ORD) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Des Moines to Chicago O'Hare Intl Airport
Frequently asked questions about flying from Des Moines to Chicago O'Hare Intl Airport
How far is Des Moines to Chicago O'Hare Intl by plane?
Des Moines and Chicago O'Hare Intl are 295.9 mi apart from one another. Flights usually cover this in 1h 32m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport?
Prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Chicago O'Hare Intl Airport?
As of October 2026, there are 2 operators available to choose from for flights from Des Moines Airport to Chicago O'Hare Intl Airport.
How old do you have to be to fly from Des Moines Airport to Chicago O'Hare Intl Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Chicago O'Hare Intl Airport.
What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?
The necessary travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Des Moines to Chicago O'Hare Intl Airport?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Des Moines to Chicago O'Hare Intl Airport is Embraer 175 (13.98% of total bookings). The next most popular plane models are Canadair (Bombardier) Regional Jet 700 (13.54%), Airbus A319 (11.32%), and Embraer 175 (Enhanced Winglets) (10.21%).
What is the most popular airline from Des Moines to Chicago O'Hare Intl Airport?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Chicago O'Hare Intl Airport is United Airlines, representing 68% of all bookings. The subsequent popular airline is American Airlines at 32%.
Best airlines flying from Des Moines to Chicago O'Hare Intl Airport
Compare and see reviews for airlines that fly from Des Moines to Chicago O'Hare Intl Airport with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $148 | Free Cancellation | Rating 7.0 12,146 reviews | |||
| PriceFrom $189 | Free Cancellation | Rating 7.4 10,322 reviews |
United Airlines Flights From Des Moines to Chicago O'Hare Intl Airport
United Airlines operates around 32 flights from Des Moines to Chicago O'Hare Intl Airport every week. The average price of these flights found in the last 72 hours has been $350, but momondo users have found United Airlines deals from Des Moines to Chicago O'Hare Intl Airport from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 10,322 reviews.
American Airlines Flights From Des Moines to Chicago O'Hare Intl Airport
Another popular option for Des Moines to Chicago O'Hare Intl Airport flights is American Airlines (7.0/10, 12,146 ratings). American Airlines flies from Des Moines to Chicago O'Hare Intl Airport around 23 times per week, with deals starting from $148 round-trip and rising to an average price of around $290.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Des Moines to Chicago?
To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Chicago from Des Moines.
Can I find flights from Des Moines to Chicago with flexible booking policies on momondo?
momondo does allow users to show only those flights to Chicago from Des Moines which offer a flexible booking policy as well as other useful filters and features.
How can momondo help me find flights from Des Moines to Chicago?
Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Des Moines.
I’m not ready to book a flight from Des Moines to Chicago right now. Can momondo alert me if prices change?
Yes momondo offers price alerts on flights to Chicago from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.