Cheap flights from Des Moines to Chicago from $109

The month of December is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Des Moines averaging around $249.

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $516. This is often the case because there is less demand to fly during this day of the week. On the other hand, Monday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $726.

Flying to Chicago O'Hare Intl Airport from Des Moines in the morning is the least expensive time of day to depart. momondo users have found prices as low as $508 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $1,009. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Des Moines to Chicago O'Hare Intl for the best Des Moines - Chicago O'Hare Intl flight prices

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $310 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Des Moines for as low as $189 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 5% on your flight if you consider stops on a Des Moines to Chicago O'Hare Intl Airport flight.

As of July 2026, prices for Des Moines to Chicago O'Hare Intl Airport flights are approximately 13% cheaper when compared to flights at the same time last year.

As of July 2026, there are 36 flights per day flying from Des Moines to Chicago O'Hare Intl Airport. The most common time of day flights depart is 6:00PM, with 33% of flights taking off at noon.

As of July 2026, there are 253 flights per week flying from Des Moines to Chicago O'Hare Intl Airport. The most common day of the week flights depart is Mon, with 18% of flights taking off on this day.