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Cheap flights from Des Moines to Chicago from $67

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Chicago departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
5:42 am - 7:24 amDSM-ORD
1h 42mnonstop
American Airlines Logo
7:00 am - 8:32 amORD-DSM
1h 32mnonstop
$189American Airlines
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Thu, Nov 6 - Sun, Nov 9
American Airlines Logo
4:02 pm - 5:34 pmDSM-ORD
1h 32mnonstop
American Airlines Logo
7:00 am - 8:32 amORD-DSM
1h 32mnonstop
$190American Airlines
Find Deal
Thu, Nov 6 - Sun, Nov 9
Multiple Airlines Logo
2:41 pm - 12:15 amDSM-ORD
9h 34m1 stop
Multiple Airlines Logo
7:05 am - 10:08 amORD-DSM
27h 03m1 stop
$191Multiple Airlines
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Thu, Nov 6 - Sun, Nov 9
United Airlines Logo
11:26 am - 12:57 pmDSM-ORD
1h 31mnonstop
United Airlines Logo
12:59 pm - 2:19 pmORD-DSM
1h 20mnonstop
$194United Airlines
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Fri, Nov 28 - Mon, Dec 1
Multiple Airlines Logo
9:03 pm - 10:42 amDSM-ORD
13h 39m1 stop
Multiple Airlines Logo
6:48 am - 10:05 amORD-DSM
27h 17m1 stop
$195Multiple Airlines
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Sun, Nov 9 - Tue, Nov 11
Delta Logo
11:01 am - 4:57 pmDSM-ORD
5h 56m1 stop
Delta Logo
6:00 am - 10:21 amORD-DSM
4h 21m1 stop
$203Delta
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Tue, Dec 9 - Thu, Dec 11
Delta Logo
5:32 pm - 9:19 pmDSM-ORD
3h 47m1 stop
Delta Logo
5:42 pm - 9:15 pmORD-DSM
3h 33m1 stop
$209Delta
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Fri, Nov 7 - Mon, Nov 10
Frontier Logo
2:32 pm - 12:16 amDSM-ORD
9h 44m1 stop
Frontier Logo
5:00 am - 12:47 pmORD-DSM
7h 47m1 stop
$234Frontier
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Fri, Oct 31 - Sun, Nov 2
United Airlines Logo
8:02 am - 9:35 amDSM-ORD
1h 33mnonstop
United Airlines Logo
12:20 am - 1:42 amORD-DSM
1h 22mnonstop
$246United Airlines
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Sat, Nov 29 - Sun, Nov 30
Frontier Logo
2:41 pm - 12:15 amDSM-ORD
9h 34m1 stop
Frontier Logo
11:43 am - 1:47 pmORD-DSM
26h 04m2 stops
$262Frontier
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Thu, Nov 6 - Sun, Nov 9

American Airlines flights from Des Moines to Chicago O'Hare Intl Airport

Our best American Airlines deals on Des Moines to Chicago O'Hare Intl Airport flight tickets
American Airlines
Nov 6
DSM5:42 amDes Moines
1h 42m
ORD7:24 amChicago O'Hare Intl
Nov 9
ORD7:00 amChicago O'Hare Intl
1h 32m
DSM8:32 amDes Moines
$189
Find similar
American Airlines
Nov 6
DSM4:02 pmDes Moines
1h 32m
ORD5:34 pmChicago O'Hare Intl
Nov 9
ORD7:00 amChicago O'Hare Intl
1h 32m
DSM8:32 amDes Moines
$190
Find similar
American Airlines
Oct 29
DSM6:07 pmDes Moines
1h 43m
ORD7:50 pmChicago O'Hare Intl
Nov 1
ORD9:50 amChicago O'Hare Intl
1h 35m
DSM11:25 amDes Moines
$199
Find similar

Delta flights from Des Moines to Chicago O'Hare Intl Airport

Our best Delta deals on Des Moines to Chicago O'Hare Intl Airport flight tickets
Delta
Dec 9
DSM11:01 amDes Moines
5h 56m
1 stop
ORD4:57 pmChicago O'Hare Intl
Dec 11
ORD6:00 amChicago O'Hare Intl
4h 21m
1 stop
DSM10:21 amDes Moines
$203
Find similar
Delta
Nov 7
DSM5:32 pmDes Moines
3h 47m
1 stop
ORD9:19 pmChicago O'Hare Intl
Nov 10
ORD5:42 pmChicago O'Hare Intl
3h 33m
1 stop
DSM9:15 pmDes Moines
$209
Find similar
Delta
Oct 30
DSM6:05 amDes Moines
6h 35m
1 stop
ORD12:40 pmChicago O'Hare Intl
Nov 2
ORD5:08 amChicago O'Hare Intl
4h 18m
1 stop
DSM9:26 amDes Moines
$219
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Des Moines to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 11/6

5:42 am-7:24 am

Nonstop1h 42m

Chicago O'Hare Intl

Sun 11/9

7:00 am-8:32 am

Nonstop1h 32m

$189

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 11/6

4:02 pm-5:34 pm

Nonstop1h 32m

Chicago O'Hare Intl

Sun 11/9

7:00 am-8:32 am

Nonstop1h 32m

$190

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 11/6

2:41 pm-12:15 am

1 stop9h 34m

Chicago O'Hare Intl

Sun 11/9

7:05 am-10:08 am

1 stop27h 03m

$191

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 11/28

11:26 am-12:57 pm

Nonstop1h 31m

Chicago O'Hare Intl

Mon 12/1

12:59 pm-2:19 pm

Nonstop1h 20m

$194

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sun 11/9

9:03 pm-10:42 am

1 stop13h 39m

Chicago O'Hare Intl

Tue 11/11

6:48 am-10:05 am

1 stop27h 17m

$195

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 12/9

11:01 am-4:57 pm

1 stop5h 56m

Chicago O'Hare Intl

Thu 12/11

6:00 am-10:21 am

1 stop4h 21m

$203

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 11/7

5:32 pm-9:19 pm

1 stop3h 47m

Chicago O'Hare Intl

Mon 11/10

5:42 pm-9:15 pm

1 stop3h 33m

$209

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 10/31

2:32 pm-12:16 am

1 stop9h 44m

Chicago O'Hare Intl

Sun 11/2

5:00 am-12:47 pm

1 stop7h 47m

$234

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sat 11/29

8:02 am-9:35 am

Nonstop1h 33m

Chicago O'Hare Intl

Sun 11/30

12:20 am-1:42 am

Nonstop1h 22m

$246

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 11/6

2:41 pm-12:15 am

1 stop9h 34m

Chicago O'Hare Intl

Sun 11/9

11:43 am-1:47 pm

2 stops26h 04m

$262

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Des Moines to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of February is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Des Moines averaging around $248.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Thursday when prices can be found for as low as $550. This is often the case because there is less demand to fly during this day of the week. On the other hand, Tuesday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $872.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Des Moines in the evening is the least expensive time of day to depart. momondo users have found prices as low as $249 when looking at flights departing in the evening. Try not to purchase tickets at noon because they tend to be around $1,071. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Des Moines to Chicago O'Hare Intl flight route?

Fly from Des Moines to Chicago O'Hare Intl for the best Des Moines - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $250 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Des Moines for as low as $189 on momondo.

What cabin class options are available on Des Moines to Chicago O'Hare Intl flights?

There are 4 cabin classes available to choose from on Des Moines to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Chicago O'Hare Intl Airport flights?

You could potentially save up to 43% on your flight if you consider stops on a Des Moines to Chicago O'Hare Intl Airport flight.

How have Des Moines to Chicago O'Hare Intl Airport flight prices changed over time?

As of October 2025, prices for Des Moines to Chicago O'Hare Intl Airport flights are approximately 338% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Chicago O'Hare Intl Airport (DSM to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Chicago O'Hare Intl Airport

Best Price Found

$213

Fastest flight time

1h 27m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Des Moines in the past 72 hours is $213. The best round-trip flight deal from Des Moines to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $357.
The fastest flight from Des Moines to Chicago O'Hare Intl Airport takes 1h 27m
Direct flights go from Des Moines to Chicago O'Hare Intl Airport every day.
Search flight deals

  • How far is Des Moines to Chicago O'Hare Intl by plane?

    Des Moines and Chicago O'Hare Intl are 295.9 mi apart from one another. Flights usually cover this in 1h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Des Moines Airport to Chicago O'Hare Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The necessary travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Des Moines to Chicago O'Hare Intl Airport?

Best airlines flying from Des Moines to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Des Moines to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $189Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
8,982 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to Chicago O'Hare Intl Airport

    United Airlines operates around 24 flights from Des Moines to Chicago O'Hare Intl Airport every week. The average price of these flights found in the last 72 hours has been $255, but momondo users have found United Airlines deals from Des Moines to Chicago O'Hare Intl Airport from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 8,982 reviews.

  • American Airlines Flights From Des Moines to Chicago O'Hare Intl Airport

    Another popular option for Des Moines to Chicago O'Hare Intl Airport flights is American Airlines (7.2/10, 11,043 ratings). American Airlines flies from Des Moines to Chicago O'Hare Intl Airport around 32 times per week, with deals starting from $189 round-trip and rising to an average price of around $244.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
South Haven
Schaumburg
Rockford
Merrillville
Gurnee
Naperville
Rosemont
Kenosha
New Buffalo
Joliet
Oak Brook
Racine
Orland Park
Hammond
Tinley Park
Janesville
Elgin
Aurora
Benton Harbor

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Chicago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Chicago from Des Moines.

Can I find flights from Des Moines to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Des Moines.

I’m not ready to book a flight from Des Moines to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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