What is the cheapest airline that flies from Des Moines to Italy?

United Airlines, Air Canada, and Lufthansa are the most popular carriers operating from Des Moines to Italy

What airlines fly to Italy?

United Airlines, Delta and KLM are the top three most popular airlines that fly to Italy from Des Moines according to our data. United Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Italy. Keep in mind that there are 4 different airlines that fly to Italy on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Italy?

Prices for flights from Des Moines Airport to Italy were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Italy?

The number of operators available for flights from Des Moines Airport to Italy is 3 as of December 2025.

How old do you have to be to fly from Des Moines Airport to Italy?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

What documentation or ID do you need to fly to Italy?

The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$251 Cheap Flights from Des Moines to Italy in 2025/26

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Find the cheapest flights from Des Moines to Italy

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:48 pm - 4:30 pm

DSM

FLR

14h 42m2 stops

6:30 am - 9:41 pm

FLR

DSM

22h 11m2 stops

$458Lufthansa

Tue, Feb 10 - Tue, Feb 17

6:48 pm - 12:35 pm

DSM

FLR

34h 47m2 stops

6:30 am - 8:07 pm

FLR

DSM

20h 37m2 stops

$471Multiple Airlines

Tue, Feb 10 - Tue, Feb 17

6:48 pm - 6:50 pm

DSM

LIN

17h 02m2 stops

6:15 am - 5:47 pm

LIN

DSM

18h 32m2 stops

$474Lufthansa

Tue, Feb 10 - Tue, Feb 17

8:00 am - 7:30 am

DSM

MXP

16h 30m2 stops

1:05 pm - 2:33 pm

MXP

DSM

32h 28m2 stops

$476United Airlines

Sun, Jan 25 - Thu, Feb 5

11:26 am - 9:05 am

DSM

MXP

14h 39m1 stop

11:05 am - 4:28 pm

MXP

DSM

36h 23m1 stop

$491Delta

Sun, Jan 25 - Mon, Feb 2

5:16 pm - 5:20 pm

DSM

VCE

17h 04m2 stops

12:20 pm - 9:24 pm

VCE

DSM

40h 04m2 stops

$493Delta

Mon, Jan 26 - Sun, Feb 8

9:03 am - 11:00 pm

DSM

FCO

30h 57m2 stops

11:15 am - 9:41 pm

FCO

DSM

41h 26m2 stops

$495United Airlines

Wed, Feb 11 - Wed, Feb 18

5:16 pm - 4:20 pm

DSM

FLR

16h 04m2 stops

6:40 am - 4:27 pm

FLR

DSM

16h 47m2 stops

$496KLM

Wed, Feb 11 - Wed, Feb 18

5:16 pm - 10:55 pm

DSM

LIN

22h 39m2 stops

6:30 am - 4:27 pm

LIN

DSM

16h 57m2 stops

$502KLM

Wed, Feb 11 - Wed, Feb 18

5:01 pm - 7:30 pm

DSM

VCE

19h 29m2 stops

6:20 am - 7:05 pm

VCE

DSM

19h 45m2 stops

$503American Airlines

Tue, Feb 10 - Tue, Feb 17

Lufthansa flights from Des Moines to Italy

Our best Lufthansa deals on Des Moines to Italy flight tickets

Lufthansa

Feb 10

DSM6:48 pmDes Moines

14h 42m

2 stops

FLR4:30 pmFlorence Peretola

Feb 17

FLR6:30 amFlorence Peretola

22h 11m

2 stops

DSM9:41 pmDes Moines

$458

Find similar

Lufthansa

Feb 10

DSM6:48 pmDes Moines

17h 02m

2 stops

LIN6:50 pmMilan Linate

Feb 17

LIN6:15 amMilan Linate

18h 32m

2 stops

DSM5:47 pmDes Moines

$474

Find similar

Lufthansa

Feb 11

DSM6:48 pmDes Moines

20h 57m

2 stops

VCE10:45 pmVenice Marco Polo

Feb 18

VCE6:55 amVenice Marco Polo

17h 52m

2 stops

DSM5:47 pmDes Moines

$479

Find similar

Delta flights from Des Moines to Italy

Our best Delta deals on Des Moines to Italy flight tickets

Delta

Jan 25

DSM5:35 amDes Moines

20h 30m

1 stop

MXP9:05 amMilan Malpensa

Feb 6

MXP11:05 amMilan Malpensa

32h 10m

1 stop

DSM12:15 pmDes Moines

$491

Find similar

Delta

Jan 26

DSM5:16 pmDes Moines

17h 04m

2 stops

VCE5:20 pmVenice Marco Polo

Feb 8

VCE12:20 pmVenice Marco Polo

40h 04m

2 stops

DSM9:24 pmDes Moines

$493

Find similar

Delta

Jan 25

DSM6:24 amDes Moines

25h 31m

2 stops

MXP2:55 pmMilan Malpensa

Feb 2

MXP11:05 amMilan Malpensa

18h 24m

1 stop

DSM10:29 pmDes Moines

$495

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 2/10

6:48 pm-4:30 pm

2 stops14h 42m

Florence Peretola

Tue 2/17

6:30 am-9:41 pm

2 stops22h 11m

$458

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Tue 2/10

6:48 pm-12:35 pm

2 stops34h 47m

Florence Peretola

Tue 2/17

6:30 am-8:07 pm

2 stops20h 37m

$471

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Tue 2/10

6:48 pm-6:50 pm

2 stops17h 02m

Milan Linate

Tue 2/17

6:15 am-5:47 pm

2 stops18h 32m

$474

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 1/25

8:00 am-7:30 am

2 stops16h 30m

Milan Malpensa

Thu 2/5

1:05 pm-2:33 pm

2 stops32h 28m

$476

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 1/25

11:26 am-9:05 am

1 stop14h 39m

Milan Malpensa

Mon 2/2

11:05 am-4:28 pm

1 stop36h 23m

$491

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Mon 1/26

5:16 pm-5:20 pm

2 stops17h 04m

Venice Marco Polo

Sun 2/8

12:20 pm-9:24 pm

2 stops40h 04m

$493

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 2/11

9:03 am-11:00 pm

2 stops30h 57m

Rome Fiumicino

Wed 2/18

11:15 am-9:41 pm

2 stops41h 26m

$495

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 2/11

5:16 pm-4:20 pm

2 stops16h 04m

Florence Peretola

Wed 2/18

6:40 am-4:27 pm

2 stops16h 47m

$496

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Wed 2/11

5:16 pm-10:55 pm

2 stops22h 39m

Milan Linate

Wed 2/18

6:30 am-4:27 pm

2 stops16h 57m

$502

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Tue 2/10

5:01 pm-7:30 pm

2 stops19h 29m

Venice Marco Polo

Tue 2/17

6:20 am-7:05 pm

2 stops19h 45m

$503

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during December instead. Flights to Italy in December, while not as cheap as those in November, still average around $773.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Fastest flight time	11h 21m
Direct flights	None

The fastest flight from Des Moines to Italy takes 11h 21m

There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.

Search flight deals

When did momondo last update prices for flights from Des Moines Airport to Italy?
Prices for flights from Des Moines Airport to Italy were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Italy?
The number of operators available for flights from Des Moines Airport to Italy is 3 as of December 2025.
How old do you have to be to fly from Des Moines Airport to Italy?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.
What documentation or ID do you need to fly to Italy?
The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $623	Free Cancellation	Rating 7.2 11,075 reviews	Search American Airlines flights
Delta	PriceFrom $641	Free Cancellation	Rating 7.9 8,015 reviews	Search Delta flights
United Airlines	PriceFrom $655	Free Cancellation	Rating 7.4 9,125 reviews	Search United Airlines flights
KLM	PriceFrom $680	Free Cancellation	Rating 7.7 1,435 reviews	Search KLM flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.