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Cheap flights from Des Moines to Italy from $239

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Italy departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Italy

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
8:00 am - 9:55 am
DSM
-
MXP
18h 55m2 stops
Air Canada Logo
1:05 pm - 11:44 pm
MXP
-
DSM
17h 39m2 stops
$418Air Canada
Wed, Jan 21 - Wed, Jan 28
Air Canada Logo
8:00 am - 9:55 am
DSM
-
MXP
18h 55m3 stops
Air Canada Logo
1:05 pm - 11:44 pm
MXP
-
DSM
17h 39m2 stops
$422Air Canada
Wed, Jan 21 - Wed, Jan 28
Air France Logo
11:26 am - 10:30 am
DSM
-
FCO
16h 04m1 stop
Air France Logo
12:40 pm - 10:29 pm
FCO
-
DSM
16h 49m1 stop
$458Air France
Thu, Jan 22 - Thu, Jan 29
Lufthansa Logo
6:48 pm - 4:30 pm
DSM
-
FLR
14h 42m2 stops
Lufthansa Logo
6:35 am - 5:47 pm
FLR
-
DSM
18h 12m2 stops
$459Lufthansa
Thu, Jan 22 - Thu, Jan 29
Air France Logo
10:21 am - 10:30 am
DSM
-
FCO
17h 09m2 stops
Air France Logo
9:55 am - 10:29 pm
FCO
-
DSM
19h 34m2 stops
$464Air France
Thu, Jan 22 - Thu, Jan 29
Lufthansa Logo
6:48 pm - 6:15 pm
DSM
-
FCO
16h 27m2 stops
Lufthansa Logo
7:05 am - 9:50 pm
FCO
-
DSM
21h 45m2 stops
$468Lufthansa
Fri, Jan 23 - Fri, Jan 30
United Airlines Logo
8:10 am - 9:55 am
DSM
-
MXP
18h 45m2 stops
United Airlines Logo
1:05 pm - 2:33 pm
MXP
-
DSM
32h 28m2 stops
$474United Airlines
Wed, Jan 21 - Wed, Jan 28
KLM Logo
5:16 pm - 10:30 am
DSM
-
FCO
34h 14m1 stop
KLM Logo
12:40 pm - 10:29 pm
FCO
-
DSM
16h 49m1 stop
$488KLM
Wed, Jan 21 - Wed, Jan 28
KLM Logo
5:35 am - 10:30 am
DSM
-
FCO
21h 55m1 stop
KLM Logo
6:10 am - 4:28 pm
FCO
-
DSM
17h 18m2 stops
$489KLM
Wed, Jan 21 - Wed, Jan 28
United Airlines Logo
5:30 am - 1:55 pm
DSM
-
TRN
25h 25m2 stops
United Airlines Logo
6:00 am - 2:33 pm
TRN
-
DSM
15h 33m2 stops
$562United Airlines
Thu, Jan 29 - Mon, Feb 2

British Airways flights from Des Moines to Italy

Our best British Airways deals on Des Moines to Italy flight tickets
British Airways
Jan 20
DSM11:42 amDes Moines
22h 13m
2 stops
VCE4:55 pmVenice Marco Polo
Jan 27
VCE6:55 amVenice Marco Polo
21h 09m
2 stops
DSM9:04 pmDes Moines
$493
Find similar
British Airways
Jan 21
DSM11:42 amDes Moines
21h 38m
2 stops
LIN4:20 pmMilan Linate
Jan 28
LIN12:40 pmMilan Linate
34h 44m
2 stops
DSM4:24 pmDes Moines
$500
Find similar
British Airways
May 3
DSM12:49 pmDes Moines
16h 41m
2 stops
LIN12:30 pmMilan Linate
Jun 1
LIN3:55 pmMilan Linate
35h 07m
2 stops
DSM8:02 pmDes Moines
$634
Find similar

Lufthansa flights from Des Moines to Italy

Our best Lufthansa deals on Des Moines to Italy flight tickets
Lufthansa
Jan 22
DSM6:48 pmDes Moines
14h 42m
2 stops
FLR4:30 pmFlorence Peretola
Jan 29
FLR6:35 amFlorence Peretola
18h 12m
2 stops
DSM5:47 pmDes Moines
$459
Find similar
Lufthansa
Jan 23
DSM6:48 pmDes Moines
16h 27m
2 stops
FCO6:15 pmRome Fiumicino
Jan 30
FCO7:05 amRome Fiumicino
21h 45m
2 stops
DSM9:50 pmDes Moines
$468
Find similar
Lufthansa
Jan 22
DSM6:48 pmDes Moines
14h 42m
2 stops
FLR4:30 pmFlorence Peretola
Jan 29
FLR6:35 amFlorence Peretola
18h 12m
2 stops
DSM5:47 pmDes Moines
$475
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/21

8:00 am-9:55 am

2 stops18h 55m

Milan Malpensa

Wed 1/28

1:05 pm-11:44 pm

2 stops17h 39m

$418

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/21

8:00 am-9:55 am

3 stops18h 55m

Milan Malpensa

Wed 1/28

1:05 pm-11:44 pm

2 stops17h 39m

$422

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Thu 1/22

11:26 am-10:30 am

1 stop16h 04m

Rome Fiumicino

Thu 1/29

12:40 pm-10:29 pm

1 stop16h 49m

$458

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 1/22

6:48 pm-4:30 pm

2 stops14h 42m

Florence Peretola

Thu 1/29

6:35 am-5:47 pm

2 stops18h 12m

$459

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Thu 1/22

10:21 am-10:30 am

2 stops17h 09m

Rome Fiumicino

Thu 1/29

9:55 am-10:29 pm

2 stops19h 34m

$464

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 1/23

6:48 pm-6:15 pm

2 stops16h 27m

Rome Fiumicino

Fri 1/30

7:05 am-9:50 pm

2 stops21h 45m

$468

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/21

8:10 am-9:55 am

2 stops18h 45m

Milan Malpensa

Wed 1/28

1:05 pm-2:33 pm

2 stops32h 28m

$474

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 1/21

5:16 pm-10:30 am

1 stop34h 14m

Rome Fiumicino

Wed 1/28

12:40 pm-10:29 pm

1 stop16h 49m

$488

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 1/21

5:35 am-10:30 am

1 stop21h 55m

Rome Fiumicino

Wed 1/28

6:10 am-4:28 pm

2 stops17h 18m

$489

Des MoinesTurin

DSM - TRN

DSMTRN

Des Moines

Thu 1/29

5:30 am-1:55 pm

2 stops25h 25m

Turin Citta Di Torino

Mon 2/2

6:00 am-2:33 pm

2 stops15h 33m

$562

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during December instead. Flights to Italy in December, while not as cheap as those in November, still average around $773.

What is the cheapest day to depart on your flight to Italy?

According to our data, Tuesday is the cheapest day to fly to Italy from Des Moines. The lowest ticket price found for a Tuesday departure recently was $1,012. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Italy for around $1,591.

What is the cheapest time of day to depart on your flight to Italy?

Our data shows that the cheapest Des Moines to Italy flights are usually those with departure times in the afternoon. Our users have found flights to Italy in the afternoon for as low as $1,222. In contrast, the most expensive time of day to depart to Italy is at noon when prices are around $1,332.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 24% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Fastest flight time

11h 35m

Direct flights

None
The fastest flight from Des Moines to Italy takes 11h 35m
There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Italy?

    Prices for flights from Des Moines Airport to Italy were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Italy?

  • How old do you have to be to fly from Des Moines Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
7.9
8,009 reviews
Search Delta flights
United AirlinesPriceFrom $655Free CancellationRating
7.4
9,090 reviews
Search United Airlines flights
KLMPriceFrom $680Free CancellationRating
7.7
1,431 reviews
Search KLM flights
LufthansaPriceFrom $738Free CancellationRating
6.8
7,619 reviews
Search Lufthansa flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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