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Cheap flights from Des Moines to Italy from $219

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Italy departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Italy

Cheap round-trip flights

Delta Logo
10:55 am - 9:05 amDSM-MXP
15h 10m2 stops
Delta Logo
12:00 pm - 4:30 pmMXP-DSM
35h 30m2 stops
$495Delta
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Sat, Jan 31 - Mon, Mar 2
Air Canada Logo
6:48 pm - 9:55 amDSM-MXP
32h 07m2 stops
Air Canada Logo
1:05 pm - 2:27 pmMXP-DSM
32h 22m2 stops
$501Air Canada
Find Deal
Sun, Feb 1 - Tue, Mar 3
United Airlines Logo
8:00 am - 9:55 amDSM-MXP
18h 55m2 stops
United Airlines Logo
1:05 pm - 9:51 pmMXP-DSM
39h 46m2 stops
$503United Airlines
Find Deal
Thu, Jan 29 - Sun, Mar 1
United Airlines Logo
8:10 am - 7:30 amDSM-MXP
16h 20m2 stops
United Airlines Logo
9:45 am - 10:35 pmMXP-DSM
19h 50m2 stops
$528United Airlines
Find Deal
Sun, Feb 1 - Thu, Feb 26
American Airlines Logo
1:48 pm - 1:35 pmDSM-LIN
16h 47m2 stops
American Airlines Logo
7:50 am - 9:56 pmLIN-DSM
21h 06m2 stops
$530American Airlines
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Mon, Oct 20 - Sat, Feb 28
British Airways Logo
6:07 pm - 6:00 pmDSM-MXP
16h 53m2 stops
British Airways Logo
1:15 pm - 9:56 pmMXP-DSM
15h 41m2 stops
$551British Airways
Find Deal
Mon, Oct 20 - Sat, Feb 28
American Airlines Logo
1:48 pm - 12:30 pmDSM-LIN
15h 42m2 stops
American Airlines Logo
11:05 am - 11:23 pmLIN-DSM
19h 18m2 stops
$560American Airlines
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Thu, Oct 16 - Thu, Oct 23
KLM Logo
6:33 pm - 10:30 amDSM-FCO
32h 57m1 stop
KLM Logo
10:05 am - 10:33 pmFCO-DSM
19h 28m1 stop
$581KLM
Find Deal
Sun, Nov 23 - Fri, Dec 5
KLM Logo
10:50 am - 6:55 amDSM-FCO
14h 05m1 stop
KLM Logo
10:05 am - 4:30 pmFCO-DSM
37h 25m1 stop
$617KLM
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Fri, Oct 31 - Fri, Nov 7
British Airways Logo
6:20 pm - 11:20 amDSM-FLR
35h 00m2 stops
British Airways Logo
12:25 pm - 6:02 pmFLR-DSM
36h 37m2 stops
$691British Airways
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Mon, Mar 9 - Sun, Mar 29

American Airlines flights from Des Moines to Italy

Our best American Airlines deals on Des Moines to Italy flight tickets
American Airlines
Oct 20
DSM1:48 pmDes Moines
16h 47m
2 stops
LIN1:35 pmMilan Linate
Feb 28
LIN7:50 amMilan Linate
21h 06m
2 stops
DSM9:56 pmDes Moines
$530
Find similar
American Airlines
Oct 16
DSM1:48 pmDes Moines
15h 42m
2 stops
LIN12:30 pmMilan Linate
Oct 23
LIN11:05 amMilan Linate
19h 18m
2 stops
DSM11:23 pmDes Moines
$560
Find similar
American Airlines
Oct 12
DSM6:22 pmDes Moines
18h 03m
2 stops
MXP7:25 pmMilan Malpensa
Oct 21
MXP1:20 pmMilan Malpensa
14h 53m
1 stop
DSM9:13 pmDes Moines
$563
Find similar

United Airlines flights from Des Moines to Italy

Our best United Airlines deals on Des Moines to Italy flight tickets
United Airlines
Jan 29
DSM8:00 amDes Moines
18h 55m
2 stops
MXP9:55 amMilan Malpensa
Mar 1
MXP1:05 pmMilan Malpensa
39h 46m
2 stops
DSM9:51 pmDes Moines
$503
Find similar
United Airlines
Feb 1
DSM8:10 amDes Moines
16h 20m
2 stops
MXP7:30 amMilan Malpensa
Feb 26
MXP9:45 amMilan Malpensa
19h 50m
2 stops
DSM10:35 pmDes Moines
$528
Find similar
United Airlines
Jan 29
DSM8:10 amDes Moines
16h 20m
2 stops
MXP7:30 amMilan Malpensa
Feb 26
MXP9:45 amMilan Malpensa
19h 50m
2 stops
DSM10:35 pmDes Moines
$529
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sat 1/31

10:55 am-9:05 am

2 stops15h 10m

Milan Malpensa

Mon 3/2

12:00 pm-4:30 pm

2 stops35h 30m

$495

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 2/1

6:48 pm-9:55 am

2 stops32h 07m

Milan Malpensa

Tue 3/3

1:05 pm-2:27 pm

2 stops32h 22m

$501

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Thu 1/29

8:00 am-9:55 am

2 stops18h 55m

Milan Malpensa

Sun 3/1

1:05 pm-9:51 pm

2 stops39h 46m

$503

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 2/1

8:10 am-7:30 am

2 stops16h 20m

Milan Malpensa

Thu 2/26

9:45 am-10:35 pm

2 stops19h 50m

$528

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Mon 10/20

1:48 pm-1:35 pm

2 stops16h 47m

Milan Linate

Sat 2/28

7:50 am-9:56 pm

2 stops21h 06m

$530

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Mon 10/20

6:07 pm-6:00 pm

2 stops16h 53m

Milan Malpensa

Sat 2/28

1:15 pm-9:56 pm

2 stops15h 41m

$551

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Thu 10/16

1:48 pm-12:30 pm

2 stops15h 42m

Milan Linate

Thu 10/23

11:05 am-11:23 pm

2 stops19h 18m

$560

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 11/23

6:33 pm-10:30 am

1 stop32h 57m

Rome Fiumicino

Fri 12/5

10:05 am-10:33 pm

1 stop19h 28m

$581

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 10/31

10:50 am-6:55 am

1 stop14h 05m

Rome Fiumicino

Fri 11/7

10:05 am-4:30 pm

1 stop37h 25m

$617

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 3/9

6:20 pm-11:20 am

2 stops35h 00m

Florence Peretola

Sun 3/29

12:25 pm-6:02 pm

2 stops36h 37m

$691

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $762, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during January instead. Flights to Italy in January, while not as cheap as those in November, still average around $802.

What is the cheapest day to depart on your flight to Italy?

According to our data, Tuesday is the cheapest day to fly to Italy from Des Moines. The lowest ticket price found for a Tuesday departure recently was $1,012. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Italy for around $1,591.

What is the cheapest time of day to depart on your flight to Italy?

Our data shows that the cheapest Des Moines to Italy flights are usually those with departure times in the afternoon. Our users have found flights to Italy in the afternoon for as low as $1,222. In contrast, the most expensive time of day to depart to Italy is at noon when prices are around $1,332.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 41% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Direct flights

None
There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.
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  • When did momondo last update prices for flights from Des Moines Airport to Italy?

    Prices for flights from Des Moines Airport to Italy were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Italy?

  • How old do you have to be to fly from Des Moines Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $647Free CancellationRating
7.9
7,961 reviews
Search Delta flights
KLMPriceFrom $680Free CancellationRating
7.8
1,386 reviews
Search KLM flights
United AirlinesPriceFrom $703Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
American AirlinesPriceFrom $725Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
LufthansaPriceFrom $811Free CancellationRating
6.8
7,409 reviews
Search Lufthansa flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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