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Cheap flights from Des Moines to Italy from $344

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Italy departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Italy

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
11:30 am - 7:45 am
DSM
-
FCO
13h 15m1 stop
Lufthansa Logo
7:05 am - 9:41 pm
FCO
-
DSM
21h 36m2 stops
$442Lufthansa
Sat, Feb 21 - Sat, Feb 28
Lufthansa Logo
11:30 am - 7:45 am
DSM
-
FCO
13h 15m1 stop
Lufthansa Logo
9:45 am - 9:41 pm
FCO
-
DSM
18h 56m1 stop
$459Lufthansa
Sat, Feb 21 - Sat, Feb 28
Lufthansa Logo
6:48 pm - 8:55 pm
DSM
-
VCE
19h 07m2 stops
Lufthansa Logo
8:00 am - 9:41 pm
VCE
-
DSM
20h 41m2 stops
$463Lufthansa
Fri, Feb 6 - Fri, Feb 13
KLM Logo
5:16 pm - 9:05 am
DSM
-
MXP
32h 49m1 stop
KLM Logo
11:05 am - 10:29 pm
MXP
-
DSM
18h 24m1 stop
$478KLM
Mon, Feb 2 - Mon, Feb 9
KLM Logo
10:21 am - 11:40 am
DSM
-
FLR
18h 19m2 stops
KLM Logo
6:40 am - 8:49 pm
FLR
-
DSM
21h 09m2 stops
$485KLM
Fri, Feb 6 - Fri, Feb 13
United Airlines Logo
7:50 am - 11:05 am
DSM
-
FCO
20h 15m2 stops
United Airlines Logo
11:15 am - 9:41 pm
FCO
-
DSM
41h 26m2 stops
$494United Airlines
Sat, Feb 7 - Sat, Feb 14
British Airways Logo
5:01 pm - 11:45 am
DSM
-
FLR
35h 44m2 stops
British Airways Logo
12:45 pm - 5:51 pm
FLR
-
DSM
36h 06m2 stops
$495British Airways
Fri, Feb 6 - Fri, Feb 13
Delta Logo
6:54 am - 11:25 am
DSM
-
FLR
21h 31m2 stops
Delta Logo
6:40 am - 4:57 pm
FLR
-
DSM
17h 17m2 stops
$499Delta
Sat, Feb 7 - Sat, Feb 14
United Airlines Logo
6:48 pm - 12:45 pm
DSM
-
VCE
34h 57m2 stops
United Airlines Logo
6:45 am - 2:22 pm
VCE
-
DSM
38h 37m2 stops
$503United Airlines
Wed, Jan 21 - Sun, Jan 25
Delta Logo
12:25 pm - 11:15 am
DSM
-
LIN
15h 50m2 stops
Delta Logo
6:30 am - 10:17 am
LIN
-
DSM
34h 47m2 stops
$504Delta
Sat, Feb 7 - Sat, Feb 14

Delta flights from Des Moines to Italy

Our best Delta deals on Des Moines to Italy flight tickets
Delta
Feb 7
DSM6:54 amDes Moines
21h 31m
2 stops
FLR11:25 amFlorence Peretola
Feb 14
FLR6:40 amFlorence Peretola
17h 17m
2 stops
DSM4:57 pmDes Moines
$499
Find similar
Delta
Feb 7
DSM12:25 pmDes Moines
15h 50m
2 stops
LIN11:15 amMilan Linate
Feb 14
LIN6:30 amMilan Linate
34h 47m
2 stops
DSM10:17 amDes Moines
$504
Find similar
Delta
Feb 6
DSM6:54 amDes Moines
20h 06m
2 stops
LIN10:00 amMilan Linate
Feb 13
LIN6:30 amMilan Linate
17h 27m
2 stops
DSM4:57 pmDes Moines
$515
Find similar

Lufthansa flights from Des Moines to Italy

Our best Lufthansa deals on Des Moines to Italy flight tickets
Lufthansa
Feb 21
DSM11:30 amDes Moines
13h 15m
1 stop
FCO7:45 amRome Fiumicino
Feb 28
FCO7:05 amRome Fiumicino
21h 36m
2 stops
DSM9:41 pmDes Moines
$442
Find similar
Lufthansa
Feb 21
DSM11:30 amDes Moines
13h 15m
1 stop
FCO7:45 amRome Fiumicino
Feb 28
FCO9:45 amRome Fiumicino
18h 56m
1 stop
DSM9:41 pmDes Moines
$459
Find similar
Lufthansa
Feb 6
DSM6:48 pmDes Moines
19h 07m
2 stops
VCE8:55 pmVenice Marco Polo
Feb 13
VCE8:00 amVenice Marco Polo
20h 41m
2 stops
DSM9:41 pmDes Moines
$463
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 25, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sat 2/21

11:30 am-7:45 am

1 stop13h 15m

Rome Fiumicino

Sat 2/28

7:05 am-9:41 pm

2 stops21h 36m

$442

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sat 2/21

11:30 am-7:45 am

1 stop13h 15m

Rome Fiumicino

Sat 2/28

9:45 am-9:41 pm

1 stop18h 56m

$459

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Fri 2/6

6:48 pm-8:55 pm

2 stops19h 07m

Venice Marco Polo

Fri 2/13

8:00 am-9:41 pm

2 stops20h 41m

$463

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Mon 2/2

5:16 pm-9:05 am

1 stop32h 49m

Milan Malpensa

Mon 2/9

11:05 am-10:29 pm

1 stop18h 24m

$478

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 2/6

10:21 am-11:40 am

2 stops18h 19m

Florence Peretola

Fri 2/13

6:40 am-8:49 pm

2 stops21h 09m

$485

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sat 2/7

7:50 am-11:05 am

2 stops20h 15m

Rome Fiumicino

Sat 2/14

11:15 am-9:41 pm

2 stops41h 26m

$494

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 2/6

5:01 pm-11:45 am

2 stops35h 44m

Florence Peretola

Fri 2/13

12:45 pm-5:51 pm

2 stops36h 06m

$495

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Sat 2/7

6:54 am-11:25 am

2 stops21h 31m

Florence Peretola

Sat 2/14

6:40 am-4:57 pm

2 stops17h 17m

$499

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Wed 1/21

6:48 pm-12:45 pm

2 stops34h 57m

Venice Marco Polo

Sun 1/25

6:45 am-2:22 pm

2 stops38h 37m

$503

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Sat 2/7

12:25 pm-11:15 am

2 stops15h 50m

Milan Linate

Sat 2/14

6:30 am-10:17 am

2 stops34h 47m

$504

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during December instead. Flights to Italy in December, while not as cheap as those in November, still average around $773.

What is the cheapest day to depart on your flight to Italy?

According to our data, Tuesday is the cheapest day to fly to Italy from Des Moines. The lowest ticket price found for a Tuesday departure recently was $1,012. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Italy for around $1,591.

What is the cheapest time of day to depart on your flight to Italy?

Our data shows that the cheapest Des Moines to Italy flights are usually those with departure times in the afternoon. Our users have found flights to Italy in the afternoon for as low as $1,222. In contrast, the most expensive time of day to depart to Italy is at noon when prices are around $1,332.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Fastest flight time

11h 21m

Direct flights

None
The fastest flight from Des Moines to Italy takes 11h 21m
There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Italy?

    Prices for flights from Des Moines Airport to Italy were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Italy?

  • How old do you have to be to fly from Des Moines Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
7.9
8,012 reviews
Search Delta flights
United AirlinesPriceFrom $655Free CancellationRating
7.4
9,114 reviews
Search United Airlines flights
KLMPriceFrom $680Free CancellationRating
7.7
1,434 reviews
Search KLM flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Find better results for your trip to Italy

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