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Cheap flights from Des Moines to Italy from $291

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Italy departing on 1/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Italy

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:48 pm - 4:40 pmDSM-MXP
14h 52m2 stops
Lufthansa Logo
6:55 am - 9:50 pmMXP-DSM
21h 55m2 stops
$417Lufthansa
Find Deal
Thu, Jan 8 - Thu, Jan 15
Lufthansa Logo
6:48 pm - 6:50 pmDSM-LIN
17h 02m2 stops
Lufthansa Logo
6:00 am - 9:50 pmLIN-DSM
22h 50m2 stops
$428Lufthansa
Find Deal
Thu, Jan 8 - Thu, Jan 15
Lufthansa Logo
6:48 pm - 6:30 pmDSM-FLR
16h 42m2 stops
Lufthansa Logo
6:30 am - 9:50 pmFLR-DSM
22h 20m2 stops
$438Lufthansa
Find Deal
Wed, Jan 7 - Wed, Jan 14
Air Canada Logo
6:48 pm - 9:55 amDSM-MXP
32h 07m2 stops
Air Canada Logo
1:05 pm - 2:33 pmMXP-DSM
32h 28m2 stops
$451Air Canada
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Wed, Jan 7 - Wed, Jan 14
United Airlines Logo
6:48 pm - 9:55 amDSM-MXP
32h 07m2 stops
United Airlines Logo
1:05 pm - 2:33 pmMXP-DSM
32h 28m2 stops
$467United Airlines
Find Deal
Wed, Jan 7 - Wed, Jan 14
Multiple Airlines Logo
3:35 pm - 12:45 pmDSM-VCE
14h 10m2 stops
Multiple Airlines Logo
6:55 am - 9:50 pmVCE-DSM
21h 55m2 stops
$470Multiple Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
6:48 pm - 9:55 amDSM-MXP
32h 07m2 stops
Multiple Airlines Logo
6:55 am - 9:50 pmMXP-DSM
21h 55m2 stops
$471Multiple Airlines
Find Deal
Wed, Jan 7 - Wed, Jan 14
United Airlines Logo
3:35 pm - 4:40 pmDSM-MXP
18h 05m2 stops
United Airlines Logo
1:05 pm - 9:50 pmMXP-DSM
39h 45m2 stops
$475United Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 15
Air Canada Logo
3:35 pm - 9:55 amDSM-MXP
35h 20m2 stops
Air Canada Logo
1:05 pm - 8:34 pmMXP-DSM
38h 29m3 stops
$477Air Canada
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Wed, Jan 7 - Wed, Jan 14
Delta Logo
11:26 am - 9:05 amDSM-MXP
14h 39m1 stop
Delta Logo
11:05 am - 10:41 amMXP-DSM
30h 36m1 stop
$490Delta
Find Deal
Wed, Jan 28 - Sun, Feb 1

Lufthansa flights from Des Moines to Italy

Our best Lufthansa deals on Des Moines to Italy flight tickets
Lufthansa
Jan 8
DSM6:48 pmDes Moines
17h 02m
2 stops
LIN6:50 pmMilan Linate
Jan 15
LIN6:00 amMilan Linate
22h 50m
2 stops
DSM9:50 pmDes Moines
$428
Find similar
Lufthansa
Jan 8
DSM6:48 pmDes Moines
16h 27m
2 stops
FCO6:15 pmRome Fiumicino
Jan 15
FCO7:05 amRome Fiumicino
21h 45m
2 stops
DSM9:50 pmDes Moines
$438
Find similar
Lufthansa
Jan 7
DSM6:48 pmDes Moines
20h 57m
2 stops
VCE10:45 pmVenice Marco Polo
Jan 14
VCE6:55 amVenice Marco Polo
21h 55m
2 stops
DSM9:50 pmDes Moines
$440
Find similar

United Airlines flights from Des Moines to Italy

Our best United Airlines deals on Des Moines to Italy flight tickets
United Airlines
Jan 7
DSM6:48 pmDes Moines
32h 07m
2 stops
MXP9:55 amMilan Malpensa
Jan 14
MXP1:05 pmMilan Malpensa
39h 45m
2 stops
DSM9:50 pmDes Moines
$467
Find similar
United Airlines
Jan 8
DSM8:00 amDes Moines
25h 40m
2 stops
MXP4:40 pmMilan Malpensa
Jan 15
MXP1:05 pmMilan Malpensa
39h 45m
2 stops
DSM9:50 pmDes Moines
$475
Find similar
United Airlines
Jan 6
DSM3:35 pmDes Moines
36h 15m
2 stops
MXP10:50 amMilan Malpensa
Jan 13
MXP1:05 pmMilan Malpensa
32h 28m
2 stops
DSM2:33 pmDes Moines
$486
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Thu 1/8

6:48 pm-4:40 pm

2 stops14h 52m

Milan Malpensa

Thu 1/15

6:55 am-9:50 pm

2 stops21h 55m

$417

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Thu 1/8

6:48 pm-6:50 pm

2 stops17h 02m

Milan Linate

Thu 1/15

6:00 am-9:50 pm

2 stops22h 50m

$428

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 1/7

6:48 pm-6:30 pm

2 stops16h 42m

Florence Peretola

Wed 1/14

6:30 am-9:50 pm

2 stops22h 20m

$438

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/7

6:48 pm-9:55 am

2 stops32h 07m

Milan Malpensa

Wed 1/14

1:05 pm-2:33 pm

2 stops32h 28m

$451

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/7

6:48 pm-9:55 am

2 stops32h 07m

Milan Malpensa

Wed 1/14

1:05 pm-2:33 pm

2 stops32h 28m

$467

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Thu 1/8

3:35 pm-12:45 pm

2 stops14h 10m

Venice Marco Polo

Thu 1/15

6:55 am-9:50 pm

2 stops21h 55m

$470

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/7

6:48 pm-9:55 am

2 stops32h 07m

Milan Malpensa

Wed 1/14

6:55 am-9:50 pm

2 stops21h 55m

$471

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Thu 1/8

3:35 pm-4:40 pm

2 stops18h 05m

Milan Malpensa

Thu 1/15

1:05 pm-9:50 pm

2 stops39h 45m

$475

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/7

3:35 pm-9:55 am

2 stops35h 20m

Milan Malpensa

Wed 1/14

1:05 pm-8:34 pm

3 stops38h 29m

$477

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/28

11:26 am-9:05 am

1 stop14h 39m

Milan Malpensa

Sun 2/1

11:05 am-10:41 am

1 stop30h 36m

$490

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during December instead. Flights to Italy in December, while not as cheap as those in November, still average around $773.

What is the cheapest day to depart on your flight to Italy?

According to our data, Tuesday is the cheapest day to fly to Italy from Des Moines. The lowest ticket price found for a Tuesday departure recently was $1,012. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Italy for around $1,591.

What is the cheapest time of day to depart on your flight to Italy?

Our data shows that the cheapest Des Moines to Italy flights are usually those with departure times in the afternoon. Our users have found flights to Italy in the afternoon for as low as $1,222. In contrast, the most expensive time of day to depart to Italy is at noon when prices are around $1,332.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 20% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Direct flights

None
There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Italy?

    Prices for flights from Des Moines Airport to Italy were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Italy?

  • How old do you have to be to fly from Des Moines Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
7.9
7,996 reviews
Search Delta flights
United AirlinesPriceFrom $655Free CancellationRating
7.4
9,039 reviews
Search United Airlines flights
KLMPriceFrom $680Free CancellationRating
7.7
1,420 reviews
Search KLM flights
LufthansaPriceFrom $811Free CancellationRating
6.8
7,583 reviews
Search Lufthansa flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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