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Cheap flights from Des Moines to Italy from $242

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Italy departing on 11/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Italy

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:46 pm - 9:55 amDSM-MXP
32h 09m2 stops
United Airlines Logo
1:05 pm - 2:33 pmMXP-DSM
32h 28m2 stops
$467United Airlines
Find Deal
Tue, Dec 30 - Wed, Jan 14
Air Canada Logo
6:46 pm - 9:55 amDSM-MXP
32h 09m2 stops
Air Canada Logo
1:05 pm - 2:33 pmMXP-DSM
32h 28m2 stops
$473Air Canada
Find Deal
Sat, Dec 27 - Tue, Jan 13
Air Canada Logo
6:46 pm - 9:55 amDSM-MXP
32h 09m2 stops
Air Canada Logo
1:05 pm - 9:50 pmMXP-DSM
39h 45m3 stops
$474Air Canada
Find Deal
Tue, Dec 30 - Tue, Jan 13
Delta Logo
11:26 am - 9:05 amDSM-MXP
14h 39m1 stop
Delta Logo
11:05 am - 4:28 pmMXP-DSM
36h 23m1 stop
$490Delta
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Wed, Jan 28 - Sun, Feb 1
Delta Logo
1:15 pm - 11:40 amDSM-MXP
15h 25m2 stops
Delta Logo
11:05 am - 4:28 pmMXP-DSM
36h 23m1 stop
$494Delta
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Wed, Dec 31 - Thu, Jan 15
Lufthansa Logo
6:48 pm - 6:15 pmDSM-FCO
16h 27m2 stops
Lufthansa Logo
7:05 am - 9:50 pmFCO-DSM
21h 45m2 stops
$494Lufthansa
Find Deal
Sat, Jan 17 - Sun, Jan 25
Lufthansa Logo
6:48 pm - 10:45 pmDSM-VCE
20h 57m2 stops
Lufthansa Logo
8:00 am - 9:51 pmVCE-DSM
20h 51m2 stops
$497Lufthansa
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Wed, Feb 11 - Sun, Feb 15
Multiple Airlines Logo
3:35 pm - 11:05 amDSM-FCO
36h 30m2 stops
Multiple Airlines Logo
9:45 am - 9:51 pmFCO-DSM
19h 06m2 stops
$500Multiple Airlines
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Fri, Feb 6 - Mon, Feb 16
Multiple Airlines Logo
1:31 pm - 9:55 amDSM-MXP
37h 24m2 stops
Multiple Airlines Logo
5:25 pm - 7:29 pmMXP-DSM
57h 04m2 stops
$529Multiple Airlines
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Wed, Dec 3 - Mon, Dec 22
KLM Logo
5:16 pm - 10:30 amDSM-FCO
34h 14m1 stop
KLM Logo
12:40 pm - 10:31 pmFCO-DSM
16h 51m1 stop
$613KLM
Find Deal
Wed, Feb 11 - Wed, Feb 18

Lufthansa flights from Des Moines to Italy

Our best Lufthansa deals on Des Moines to Italy flight tickets
Lufthansa
Jan 17
DSM6:48 pmDes Moines
16h 27m
2 stops
FCO6:15 pmRome Fiumicino
Jan 25
FCO7:05 amRome Fiumicino
21h 45m
2 stops
DSM9:50 pmDes Moines
$494
Find similar
Lufthansa
Feb 11
DSM6:48 pmDes Moines
20h 57m
2 stops
VCE10:45 pmVenice Marco Polo
Feb 15
VCE8:00 amVenice Marco Polo
20h 51m
2 stops
DSM9:51 pmDes Moines
$497
Find similar
Lufthansa
Dec 3
DSM6:50 pmDes Moines
17h 00m
2 stops
LIN6:50 pmMilan Linate
Dec 22
LIN7:40 pmMilan Linate
54h 49m
2 stops
DSM7:29 pmDes Moines
$559
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KLM flights from Des Moines to Italy

Our best KLM deals on Des Moines to Italy flight tickets
KLM
Feb 11
DSM5:16 pmDes Moines
34h 14m
1 stop
FCO10:30 amRome Fiumicino
Feb 18
FCO12:40 pmRome Fiumicino
16h 51m
1 stop
DSM10:31 pmDes Moines
$613
Find similar
KLM
Dec 15
DSM11:23 amDes Moines
16h 07m
1 stop
FCO10:30 amRome Fiumicino
Dec 22
FCO10:05 amRome Fiumicino
17h 39m
1 stop
DSM8:44 pmDes Moines
$767
Find similar
KLM
Dec 15
DSM2:16 pmDes Moines
13h 14m
1 stop
FCO10:30 amRome Fiumicino
Dec 22
FCO12:40 pmRome Fiumicino
16h 51m
1 stop
DSM10:31 pmDes Moines
$769
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Tue 12/30

6:46 pm-9:55 am

2 stops32h 09m

Milan Malpensa

Wed 1/14

1:05 pm-2:33 pm

2 stops32h 28m

$467

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sat 12/27

6:46 pm-9:55 am

2 stops32h 09m

Milan Malpensa

Tue 1/13

1:05 pm-2:33 pm

2 stops32h 28m

$473

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Tue 12/30

6:46 pm-9:55 am

2 stops32h 09m

Milan Malpensa

Tue 1/13

1:05 pm-9:50 pm

3 stops39h 45m

$474

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 1/28

11:26 am-9:05 am

1 stop14h 39m

Milan Malpensa

Sun 2/1

11:05 am-4:28 pm

1 stop36h 23m

$490

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 12/31

1:15 pm-11:40 am

2 stops15h 25m

Milan Malpensa

Thu 1/15

11:05 am-4:28 pm

1 stop36h 23m

$494

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sat 1/17

6:48 pm-6:15 pm

2 stops16h 27m

Rome Fiumicino

Sun 1/25

7:05 am-9:50 pm

2 stops21h 45m

$494

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Wed 2/11

6:48 pm-10:45 pm

2 stops20h 57m

Venice Marco Polo

Sun 2/15

8:00 am-9:51 pm

2 stops20h 51m

$497

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 2/6

3:35 pm-11:05 am

2 stops36h 30m

Rome Fiumicino

Mon 2/16

9:45 am-9:51 pm

2 stops19h 06m

$500

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 12/3

1:31 pm-9:55 am

2 stops37h 24m

Milan Malpensa

Mon 12/22

5:25 pm-7:29 pm

2 stops57h 04m

$529

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 2/11

5:16 pm-10:30 am

1 stop34h 14m

Rome Fiumicino

Wed 2/18

12:40 pm-10:31 pm

1 stop16h 51m

$613

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during December instead. Flights to Italy in December, while not as cheap as those in November, still average around $773.

What is the cheapest day to depart on your flight to Italy?

According to our data, Tuesday is the cheapest day to fly to Italy from Des Moines. The lowest ticket price found for a Tuesday departure recently was $1,012. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Italy for around $1,591.

What is the cheapest time of day to depart on your flight to Italy?

Our data shows that the cheapest Des Moines to Italy flights are usually those with departure times in the afternoon. Our users have found flights to Italy in the afternoon for as low as $1,222. In contrast, the most expensive time of day to depart to Italy is at noon when prices are around $1,332.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 20% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Direct flights

None
There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.
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  • When did momondo last update prices for flights from Des Moines Airport to Italy?

    Prices for flights from Des Moines Airport to Italy were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Italy?

  • How old do you have to be to fly from Des Moines Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
7.9
8,006 reviews
Search Delta flights
United AirlinesPriceFrom $655Free CancellationRating
7.4
9,014 reviews
Search United Airlines flights
KLMPriceFrom $680Free CancellationRating
7.7
1,411 reviews
Search KLM flights
LufthansaPriceFrom $811Free CancellationRating
6.8
7,576 reviews
Search Lufthansa flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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