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Cheap flights from Des Moines to Italy from $291

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Italy departing on 10/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Italy

Cheap round-trip flights

Logo
8:47 pm - 1:40 pmDSM-FCO
34h 53m2 stops
Logo
7:10 pm - 12:55 pmFCO-DSM
24h 45m1 stop
$510
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Sun, Oct 26 - Thu, Nov 20
United Airlines Logo
1:45 pm - 9:55 amDSM-MXP
37h 10m2 stops
United Airlines Logo
1:05 pm - 9:36 pmMXP-DSM
39h 31m2 stops
$512United Airlines
Find Deal
Tue, Jan 6 - Wed, Jan 14
American Airlines Logo
6:00 am - 11:20 amDSM-MXP
22h 20m1 stop
American Airlines Logo
1:20 pm - 9:13 pmMXP-DSM
14h 53m1 stop
$592American Airlines
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Sun, Oct 12 - Tue, Oct 21
American Airlines Logo
6:07 pm - 7:25 pmDSM-MXP
18h 18m2 stops
American Airlines Logo
1:20 pm - 9:13 pmMXP-DSM
14h 53m1 stop
$595American Airlines
Find Deal
Sun, Oct 12 - Tue, Oct 21
Delta Logo
11:04 am - 11:25 amDSM-VCE
17h 21m2 stops
Delta Logo
1:20 pm - 9:30 amVCE-DSM
27h 10m2 stops
$605Delta
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Sun, Feb 8 - Thu, Feb 19
British Airways Logo
6:15 pm - 4:50 pmDSM-VCE
15h 35m2 stops
British Airways Logo
6:55 am - 9:56 pmVCE-DSM
22h 01m2 stops
$618British Airways
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Mon, Feb 9 - Thu, Feb 19
Delta Logo
6:05 am - 6:05 amDSM-FCO
18h 00m2 stops
Delta Logo
9:20 am - 8:35 pmFCO-DSM
18h 15m2 stops
$620Delta
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Wed, Oct 29 - Wed, Nov 5
British Airways Logo
6:15 pm - 8:20 pmDSM-VCE
19h 05m2 stops
British Airways Logo
6:55 am - 9:56 pmVCE-DSM
22h 01m2 stops
$628British Airways
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Mon, Feb 9 - Fri, Feb 20
KLM Logo
5:47 am - 9:30 amDSM-FCO
21h 43m1 stop
KLM Logo
10:05 am - 8:50 pmFCO-DSM
17h 45m1 stop
$660KLM
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Sun, Oct 26 - Thu, Nov 20
KLM Logo
11:04 am - 7:55 amDSM-FCO
13h 51m1 stop
KLM Logo
10:05 am - 10:23 pmFCO-DSM
19h 18m1 stop
$665KLM
Find Deal
Mon, Nov 10 - Mon, Nov 17

KLM flights from Des Moines to Italy

Our best KLM deals on Des Moines to Italy flight tickets
KLM
Oct 26
DSM5:47 amDes Moines
21h 43m
1 stop
FCO9:30 amRome Fiumicino
Nov 20
FCO10:05 amRome Fiumicino
17h 45m
1 stop
DSM8:50 pmDes Moines
$660
Find similar
KLM
Nov 10
DSM11:04 amDes Moines
13h 51m
1 stop
FCO7:55 amRome Fiumicino
Nov 17
FCO10:05 amRome Fiumicino
19h 18m
1 stop
DSM10:23 pmDes Moines
$665
Find similar
KLM
Oct 29
DSM2:13 pmDes Moines
13h 17m
1 stop
FCO9:30 amRome Fiumicino
Nov 5
FCO12:40 pmRome Fiumicino
16h 50m
1 stop
DSM10:30 pmDes Moines
$715
Find similar

Iberia flights from Des Moines to Italy

Our best Iberia deals on Des Moines to Italy flight tickets
Iberia
Oct 12
DSM6:07 pmDes Moines
32h 03m
1 stop
FCO9:10 amRome Fiumicino
Oct 21
FCO8:25 pmRome Fiumicino
30h 46m
2 stops
DSM8:11 pmDes Moines
$747
Find similar
Iberia
Aug 25
DSM5:14 pmDes Moines
18h 01m
2 stops
FCO6:15 pmRome Fiumicino
Sep 10
FCO10:15 pmRome Fiumicino
26h 24m
2 stops
DSM5:39 pmDes Moines
$1,135
Find similar
Iberia
Aug 27
DSM1:09 pmDes Moines
13h 01m
1 stop
FCO9:10 amRome Fiumicino
Sep 10
FCO8:50 pmRome Fiumicino
30h 31m
2 stops
DSM8:21 pmDes Moines
$1,357
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 10/26

8:47 pm-1:40 pm

2 stops34h 53m

Rome Fiumicino

Thu 11/20

7:10 pm-12:55 pm

1 stop24h 45m

$510

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Tue 1/6

1:45 pm-9:55 am

2 stops37h 10m

Milan Malpensa

Wed 1/14

1:05 pm-9:36 pm

2 stops39h 31m

$512

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 10/12

6:00 am-11:20 am

1 stop22h 20m

Milan Malpensa

Tue 10/21

1:20 pm-9:13 pm

1 stop14h 53m

$592

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Sun 10/12

6:07 pm-7:25 pm

2 stops18h 18m

Milan Malpensa

Tue 10/21

1:20 pm-9:13 pm

1 stop14h 53m

$595

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Sun 2/8

11:04 am-11:25 am

2 stops17h 21m

Venice Marco Polo

Thu 2/19

1:20 pm-9:30 am

2 stops27h 10m

$605

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Mon 2/9

6:15 pm-4:50 pm

2 stops15h 35m

Venice Marco Polo

Thu 2/19

6:55 am-9:56 pm

2 stops22h 01m

$618

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 10/29

6:05 am-6:05 am

2 stops18h 00m

Rome Fiumicino

Wed 11/5

9:20 am-8:35 pm

2 stops18h 15m

$620

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Mon 2/9

6:15 pm-8:20 pm

2 stops19h 05m

Venice Marco Polo

Fri 2/20

6:55 am-9:56 pm

2 stops22h 01m

$628

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 10/26

5:47 am-9:30 am

1 stop21h 43m

Rome Fiumicino

Thu 11/20

10:05 am-8:50 pm

1 stop17h 45m

$660

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/10

11:04 am-7:55 am

1 stop13h 51m

Rome Fiumicino

Mon 11/17

10:05 am-10:23 pm

1 stop19h 18m

$665

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $654, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during January instead. Flights to Italy in January, while not as cheap as those in November, still average around $802.

What is the cheapest day to depart on your flight to Italy?

According to our data, Tuesday is the cheapest day to fly to Italy from Des Moines. The lowest ticket price found for a Tuesday departure recently was $1,012. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Italy for around $1,591.

What is the cheapest time of day to depart on your flight to Italy?

Our data shows that the cheapest Des Moines to Italy flights are usually those with departure times in the afternoon. Our users have found flights to Italy in the afternoon for as low as $1,222. In contrast, the most expensive time of day to depart to Italy is at noon when prices are around $1,332.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 34% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Best Price Found

$291

Fastest flight time

11h 44m

Direct flights

None

Airports in Italy

6 airports
The best one-way flight to Italy from Des Moines in the past 72 hours is $291. The best round-trip flight deal from Des Moines to Italy found on momondo in the last 72 hours is $510.
The fastest flight from Des Moines to Italy takes 11h 44m
There are no direct flights from Des Moines to Italy. Popular non-direct routes for this connection are Des Moines Airport - Venice Marco Polo Airport, Des Moines Airport - Milan Linate Airport and Des Moines Airport - Milan Malpensa Airport.
There are 6 airports near Italy: Milan Linate (LIN), Turin Citta Di Torino (TRN), Rome Fiumicino (FCO), Milan Malpensa (MXP), Venice Marco Polo (VCE), Florence Peretola (FLR)
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  • When did momondo last update prices for flights from Des Moines Airport to Italy?

    Prices for flights from Des Moines Airport to Italy were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Italy?

  • How old do you have to be to fly from Des Moines Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
8.0
7,981 reviews
Search Delta flights
KLMPriceFrom $680Free CancellationRating
7.8
1,385 reviews
Search KLM flights
United AirlinesPriceFrom $703Free CancellationRating
7.4
8,925 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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