What airlines fly to Italy?

United Airlines, Delta and KLM are the top three most popular airlines that fly to Italy from Des Moines according to our data. United Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Italy. Keep in mind that there are 4 different airlines that fly to Italy on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Italy?

United Airlines, KLM, and Air France are the most popular carriers operating from Des Moines to Italy

When did momondo last update prices for flights from Des Moines Airport to Italy?

Prices for flights from Des Moines Airport to Italy were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Italy?

The number of operators available for flights from Des Moines Airport to Italy is 3 as of January 2026.

How old do you have to be to fly from Des Moines Airport to Italy?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.

What documentation or ID do you need to fly to Italy?

The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$320 Cheap Flights from Des Moines to Italy in 2026

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Find the cheapest flights from Des Moines to Italy

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:24 pm - 9:55 am

DSM

MXP

35h 31m

2 stops

12:05 pm - 10:30 am

MXP

DSM

28h 25m

2 stops

$475United Airlines

Tue, Mar 3 - Tue, Mar 10

2:04 pm - 11:15 am

DSM

VCE

15h 11m

2 stops

6:45 am - 9:40 pm

VCE

DSM

20h 55m

2 stops

$481Multiple Airlines

Tue, Mar 10 - Tue, Mar 17

8:00 am - 10:55 am

DSM

FCO

19h 55m

2 stops

7:00 am - 6:08 pm

FCO

DSM

17h 08m

2 stops

$482Multiple Airlines

Tue, Mar 3 - Tue, Mar 10

5:24 am - 9:05 am

DSM

MXP

20h 41m

1 stop

10:05 am - 10:38 pm

MXP

DSM

18h 33m

1 stop

$488KLM

Tue, Mar 3 - Tue, Mar 10

2:18 pm - 10:20 pm

DSM

FLR

25h 02m

2 stops

7:05 am - 11:29 pm

FLR

DSM

23h 24m

2 stops

$489British Airways

Wed, Apr 15 - Wed, Apr 22

7:44 pm - 9:25 pm

DSM

VCE

19h 41m

2 stops

8:25 pm - 11:40 pm

VCE

DSM

33h 15m

2 stops

$494British Airways

Sun, Mar 8 - Sun, Mar 15

5:24 am - 9:45 am

DSM

MXP

21h 21m

2 stops

10:05 am - 10:38 pm

MXP

DSM

18h 33m

1 stop

$496Delta

Wed, Mar 4 - Wed, Mar 11

5:20 pm - 3:55 pm

DSM

LIN

16h 35m

2 stops

6:30 am - 4:54 pm

LIN

DSM

16h 24m

2 stops

$503KLM

Tue, Mar 10 - Tue, Mar 17

5:15 pm - 6:50 pm

DSM

MXP

18h 35m

2 stops

6:55 am - 9:10 pm

MXP

DSM

20h 15m

2 stops

$506Delta

Wed, Mar 4 - Wed, Mar 11

1:38 pm - 11:30 am

DSM

LIN

14h 52m

2 stops

12:40 pm - 11:40 pm

LIN

DSM

17h 00m

2 stops

$506American Airlines

Wed, Mar 4 - Wed, Mar 11

American Airlines flights from Des Moines to Italy

Our best American Airlines deals on Des Moines to Italy flight tickets

American Airlines

Mar 4

DSM1:38 pmDes Moines

14h 52m

2 stops

LIN11:30 amMilan Linate

Mar 11

LIN12:40 pmMilan Linate

17h 00m

2 stops

DSM11:40 pmDes Moines

$506

American Airlines

May 12

DSM2:18 pmDes Moines

16h 22m

2 stops

MXP1:40 pmMilan Malpensa

May 22

MXP7:25 amMilan Malpensa

17h 34m

2 stops

DSM5:59 pmDes Moines

$594

American Airlines

Apr 26

DSM6:00 amDes Moines

20h 10m

1 stop

FCO9:10 amRome Fiumicino

May 17

FCO10:00 amRome Fiumicino

20h 29m

1 stop

DSM11:29 pmDes Moines

$713

Delta flights from Des Moines to Italy

Our best Delta deals on Des Moines to Italy flight tickets

Delta

Mar 4

DSM5:24 amDes Moines

21h 21m

2 stops

MXP9:45 amMilan Malpensa

Mar 11

MXP10:05 amMilan Malpensa

18h 33m

1 stop

DSM10:38 pmDes Moines

$496

Delta

Mar 4

DSM5:15 pmDes Moines

18h 35m

2 stops

MXP6:50 pmMilan Malpensa

Mar 11

MXP6:55 amMilan Malpensa

20h 15m

2 stops

DSM9:10 pmDes Moines

$506

Delta

Mar 3

DSM12:25 pmDes Moines

19h 50m

2 stops

FCO3:15 pmRome Fiumicino

Mar 10

FCO9:05 amRome Fiumicino

17h 40m

1 stop

DSM8:45 pmDes Moines

$512

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Tue 3/3

3:24 pm-9:55 am

2 stops35h 31m

Milan Malpensa

Tue 3/10

12:05 pm-10:30 am

2 stops28h 25m

$475

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Tue 3/10

2:04 pm-11:15 am

2 stops15h 11m

Venice Marco Polo

Tue 3/17

6:45 am-9:40 pm

2 stops20h 55m

$481

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 3/3

8:00 am-10:55 am

2 stops19h 55m

Rome Fiumicino

Tue 3/10

7:00 am-6:08 pm

2 stops17h 08m

$482

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Tue 3/3

5:24 am-9:05 am

1 stop20h 41m

Milan Malpensa

Tue 3/10

10:05 am-10:38 pm

1 stop18h 33m

$488

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 4/15

2:18 pm-10:20 pm

2 stops25h 02m

Florence Peretola

Wed 4/22

7:05 am-11:29 pm

2 stops23h 24m

$489

Des MoinesVenice

DSM - VCE

DSMVCE

Des Moines

Sun 3/8

7:44 pm-9:25 pm

2 stops19h 41m

Venice Marco Polo

Sun 3/15

8:25 pm-11:40 pm

2 stops33h 15m

$494

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 3/4

5:24 am-9:45 am

2 stops21h 21m

Milan Malpensa

Wed 3/11

10:05 am-10:38 pm

1 stop18h 33m

$496

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Tue 3/10

5:20 pm-3:55 pm

2 stops16h 35m

Milan Linate

Tue 3/17

6:30 am-4:54 pm

2 stops16h 24m

$503

Des MoinesMilan

DSM - MXP

DSMMXP

Des Moines

Wed 3/4

5:15 pm-6:50 pm

2 stops18h 35m

Milan Malpensa

Wed 3/11

6:55 am-9:10 pm

2 stops20h 15m

$506

Des MoinesMilan

DSM - LIN

DSMLIN

Des Moines

Wed 3/4

1:38 pm-11:30 am

2 stops14h 52m

Milan Linate

Wed 3/11

12:40 pm-11:40 pm

2 stops17h 00m

$506

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Italy from Des Moines during December instead. Flights to Italy in December, while not as cheap as those in November, still average around $689.

Can stopping save me money on Des Moines to Italy flights?

You could potentially save up to 9% on your flight if you consider stops on a Des Moines to Italy flight.

Cheap Des Moines to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Italy

Fastest flight time	12h 25m
Direct flights	None

The fastest flight from Des Moines to Italy takes 12h 25m

There are no direct flights from Des Moines to Italy. There are no popular flight routes from Des Moines to Italy.

Search flight deals

When did momondo last update prices for flights from Des Moines Airport to Italy?
Prices for flights from Des Moines Airport to Italy were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Italy?
The number of operators available for flights from Des Moines Airport to Italy is 3 as of January 2026.
How old do you have to be to fly from Des Moines Airport to Italy?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Italy.
What documentation or ID do you need to fly to Italy?
The travel and health documents required for your trip to Italy can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Italy. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to Italy

Compare and see reviews for airlines that fly from Des Moines to Italy with momondo

Airline	Rating	Free Cancellation	Price
KLM	PriceFrom $457	Free Cancellation	Rating 7.7 1,443 reviews	Search KLM flights
United Airlines	PriceFrom $502	Free Cancellation	Rating 7.4 9,207 reviews	Search United Airlines flights
Delta	PriceFrom $505	Free Cancellation	Rating 7.9 8,121 reviews	Search Delta flights
American Airlines	PriceFrom $623	Free Cancellation	Rating 7.2 11,198 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Italy?

Finding the right flight to Italy from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Italy quick and easy, saving you time and money.

Can I find flights from Des Moines to Italy with flexible booking policies on momondo?

momondo does allow users to show only those flights to Italy from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Italy?

Once all potential Des Moines to Italy flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Italy right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Italy from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.