Flights South America Chicago to South America

Cheap flights from Chicago to South America

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Easily compare round-trip flights from Chicago to South America

Below you can see the best fares for your round-trip flight route over the next three months. All fares were found on momondo this week. Browse the quickest and cheapest flights from Chicago to South America by changing tabs
Quickest
Cheapest
Spirit Airlines
Spirit Airlines
21 Jan
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 19m
1 Stop
7:19 am
+1
CTG
Cartagena Rafael Nunez airport
Spirit Airlines
28 Jan
CTG
12:00 am
Cartagena Rafael Nunez airport
10h 29m
1 Stop
9:29 am
ORD
Chicago O'Hare Intl airport
272 USD
Spirit Airlines
Spirit Airlines
15 Nov
ORD
11:00 pm
Chicago O'Hare Intl airport
18h 45m
1 Stop
6:45 pm
+1
BOG
Bogotá El Dorado airport
Spirit Airlines
20 Nov
BOG
12:00 am
Bogotá El Dorado airport
9h 26m
1 Stop
8:26 am
ORD
Chicago O'Hare Intl airport
320 USD
Spirit Airlines
Spirit Airlines
27 Jan
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 59m
1 Stop
7:59 am
+1
BOG
Bogotá El Dorado airport
Spirit Airlines
31 Jan
BOG
12:00 am
Bogotá El Dorado airport
18h 35m
1 Stop
5:35 pm
ORD
Chicago O'Hare Intl airport
330 USD
Spirit Airlines
Spirit Airlines
06 Dec
ORD
11:00 pm
Chicago O'Hare Intl airport
21h 29m
2 Stops
9:29 pm
+1
CTG
Cartagena Rafael Nunez airport
Spirit Airlines
10 Dec
CTG
12:00 am
Cartagena Rafael Nunez airport
20h 23m
1 Stop
7:23 pm
ORD
Chicago O'Hare Intl airport
349 USD
Spirit Airlines
Spirit Airlines
02 Nov
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 31m
1 Stop
6:31 am
+1
CTG
Cartagena Rafael Nunez airport
Spirit Airlines
05 Nov
CTG
12:00 am
Cartagena Rafael Nunez airport
11h 24m
1 Stop
10:24 am
ORD
Chicago O'Hare Intl airport
360 USD
Interjet
Interjet
29 Feb
ORD
11:00 pm
Chicago O'Hare Intl airport
27h 47m
2 Stops
3:47 am
+2
CTG
Cartagena Rafael Nunez airport
Interjet
06 Mar
CTG
12:00 am
Cartagena Rafael Nunez airport
18h 56m
2 Stops
5:56 pm
ORD
Chicago O'Hare Intl airport
365 USD
Spirit Airlines
Spirit Airlines
21 Jan
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 19m
1 Stop
7:19 am
+1
CTG
Cartagena Rafael Nunez airport
Spirit Airlines
28 Jan
CTG
12:00 am
Cartagena Rafael Nunez airport
10h 29m
1 Stop
9:29 am
ORD
Chicago O'Hare Intl airport
272 USD
Spirit Airlines
Spirit Airlines
02 Nov
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 31m
1 Stop
6:31 am
+1
CTG
Cartagena Rafael Nunez airport
Spirit Airlines
05 Nov
CTG
12:00 am
Cartagena Rafael Nunez airport
11h 24m
1 Stop
10:24 am
ORD
Chicago O'Hare Intl airport
360 USD
Spirit Airlines
Spirit Airlines
02 Nov
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 31m
1 Stop
6:31 am
+1
CTG
Cartagena Rafael Nunez airport
Spirit Airlines
09 Nov
CTG
12:00 am
Cartagena Rafael Nunez airport
11h 24m
1 Stop
10:24 am
ORD
Chicago O'Hare Intl airport
373 USD
Delta
Delta
12 Oct
ORD
11:00 pm
Chicago O'Hare Intl airport
8h 37m
1 Stop
7:37 am
+1
UIO
Quito Mariscal Sucr airport
Delta
19 Oct
UIO
11:00 pm
Quito Mariscal Sucr airport
12h 38m
1 Stop
11:38 am
+1
ORD
Chicago O'Hare Intl airport
564 USD
JetBlue
JetBlue
04 Mar
ORD
11:00 pm
Chicago O'Hare Intl airport
9h 31m
1 Stop
9:31 am
+1
CTG
Cartagena Rafael Nunez airport
JetBlue
09 Mar
CTG
11:00 pm
Cartagena Rafael Nunez airport
14h 40m
1 Stop
1:40 pm
+1
ORD
Chicago O'Hare Intl airport
501 USD
Spirit Airlines
Spirit Airlines
27 Jan
ORD
11:00 pm
Chicago O'Hare Intl airport
7h 59m
1 Stop
7:59 am
+1
BOG
Bogotá El Dorado airport
Spirit Airlines
31 Jan
BOG
12:00 am
Bogotá El Dorado airport
18h 35m
1 Stop
5:35 pm
ORD
Chicago O'Hare Intl airport
330 USD

Alternative routes for Chicago to South America

Compare alternative flights to and from nearby airports and cities to discover the best prices and most convenient flight times
Chicago to Cartagena
Fastest flight time
7h 11m
Cheapest price
272 USD
Chicago to Cali
Fastest flight time
7h 36m
Cheapest price
294 USD
Chicago to Bogotá
Fastest flight time
7h 59m
Cheapest price
305 USD
Indianapolis to Bogotá
Fastest flight time
7h 45m
Cheapest price
359 USD
Chicago to Lima
Fastest flight time
10h 18m
Cheapest price
376 USD
Chicago to Medellín
Fastest flight time
8h 04m
Cheapest price
384 USD
Chicago to Guayaquil
Fastest flight time
15h 16m
Cheapest price
407 USD
Chicago to Quito
Fastest flight time
9h 58m
Cheapest price
408 USD
Indianapolis to Lima
Fastest flight time
12h 54m
Cheapest price
568 USD
Chicago to Cusco
Fastest flight time
17h 10m
Cheapest price
640 USD
Chicago to Sao Paulo
Fastest flight time
9h 20m
Cheapest price
644 USD
Chicago to Santiago
Fastest flight time
13h 35m
Cheapest price
658 USD
Chicago to Rio de Janeiro
Fastest flight time
12h 50m
Cheapest price
804 USD
Indianapolis to Santiago
Fastest flight time
14h 40m
Cheapest price
860 USD
Chicago to Buenos Aires
Fastest flight time
15h 05m
Cheapest price
906 USD
Indianapolis to Cusco
Fastest flight time
22h 45m
Cheapest price
945 USD
Chicago to Belo Horizonte
Fastest flight time
24h 30m
Cheapest price
953 USD
Indianapolis to Rio de Janeiro
Fastest flight time
19h 45m
Cheapest price
1,176 USD
Indianapolis to Sao Paulo
Fastest flight time
12h 39m
Cheapest price
1,180 USD
View more
Flights South America Chicago to South America