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Cheap flights from Buffalo to Panama from $261

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama departing on 4/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Buffalo to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:41 pm - 8:34 pm
BUF
-
PTY
8h 53m
1 stop
Multiple Airlines Logo
10:26 am - 10:41 am
PTY
-
BUF
23h 15m
1 stop
$570Multiple Airlines
Sat, May 9 - Sat, May 16
Multiple Airlines Logo
7:55 pm - 10:30 am
BUF
-
PTY
15h 35m
2 stops
Multiple Airlines Logo
3:50 pm - 9:27 pm
PTY
-
BUF
28h 37m
2 stops
$577Multiple Airlines
Fri, May 8 - Fri, May 15
Multiple Airlines Logo
7:02 pm - 10:30 am
BUF
-
PTY
16h 28m
2 stops
Multiple Airlines Logo
5:30 am - 8:58 am
PTY
-
BUF
26h 28m
2 stops
$580Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
7:55 pm - 2:55 pm
BUF
-
PTY
20h 00m
3 stops
Multiple Airlines Logo
3:50 pm - 9:27 pm
PTY
-
BUF
28h 37m
2 stops
$583Multiple Airlines
Fri, May 8 - Fri, May 15
Multiple Airlines Logo
7:02 pm - 2:55 pm
BUF
-
PTY
20h 53m
3 stops
Multiple Airlines Logo
5:30 am - 8:58 am
PTY
-
BUF
26h 28m
2 stops
$586Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
7:55 pm - 10:30 am
BUF
-
PTY
15h 35m
2 stops
Multiple Airlines Logo
3:50 pm - 9:31 am
PTY
-
BUF
16h 41m
2 stops
$588Multiple Airlines
Sat, May 9 - Sat, May 16
Multiple Airlines Logo
7:00 am - 10:30 am
BUF
-
PTY
28h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 2:58 pm
PTY
-
BUF
22h 08m
2 stops
$618Multiple Airlines
Sun, Apr 26 - Sat, May 2
Multiple Airlines Logo
7:02 pm - 2:55 pm
BUF
-
PTY
20h 53m
3 stops
Multiple Airlines Logo
11:25 am - 8:58 am
PTY
-
BUF
20h 33m
3 stops
$621Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
United Airlines Logo
5:52 pm - 2:14 pm
BUF
-
PTY
21h 22m
2 stops
United Airlines Logo
3:20 pm - 9:49 am
PTY
-
BUF
17h 29m
2 stops
$640United Airlines
Tue, Sep 22 - Fri, Sep 25
Multiple Airlines Logo
7:00 am - 2:55 pm
BUF
-
PTY
32h 55m
3 stops
Multiple Airlines Logo
3:50 pm - 9:30 am
PTY
-
BUF
16h 40m
2 stops
$641Multiple Airlines
Sun, Apr 26 - Sat, May 2

United Airlines flights from Buffalo to Panama

Our best United Airlines deals on Buffalo to Panama flight tickets
United Airlines
Sep 22
BUF5:52 pmBuffalo
21h 22m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Sep 25
PTY3:20 pmPanama City Tocumen Intl
17h 29m
2 stops
BUF9:49 amBuffalo
$640
United Airlines
Apr 15
BUF10:30 amBuffalo
10h 01m
1 stop
PTY7:31 pmPanama City Tocumen Intl
Apr 22
PTY10:55 pmPanama City Tocumen Intl
9h 52m
1 stop
BUF9:47 amBuffalo
$649
United Airlines
Jul 24
BUF7:00 pmBuffalo
10h 04m
1 stop
PTY4:04 amPanama City Tocumen Intl
Jul 28
PTY10:55 pmPanama City Tocumen Intl
9h 58m
1 stop
BUF9:53 amBuffalo
$676

American Airlines flights from Buffalo to Panama

Our best American Airlines deals on Buffalo to Panama flight tickets
American Airlines
Apr 2
BUF5:29 pmBuffalo
22h 32m
2 stops
PTY3:01 pmPanama City Tocumen Intl
Apr 24
PTY1:49 pmPanama City Tocumen Intl
23h 32m
2 stops
BUF2:21 pmBuffalo
$750
American Airlines
Apr 2
BUF5:29 pmBuffalo
22h 32m
2 stops
PTY3:01 pmPanama City Tocumen Intl
Apr 25
PTY1:49 pmPanama City Tocumen Intl
20h 02m
2 stops
BUF10:51 amBuffalo
$787
American Airlines
Jul 10
BUF7:34 pmBuffalo
17h 40m
3 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 13
PTY1:14 pmPanama City Tocumen Intl
9h 45m
2 stops
BUF11:59 pmBuffalo
$2,611

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 5/9

12:41 pm-8:34 pm

1 stop8h 53m

Panama City Tocumen Intl

Sat 5/16

10:26 am-10:41 am

1 stop23h 15m

$570

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 5/8

7:55 pm-10:30 am

2 stops15h 35m

Panama City Tocumen Intl

Fri 5/15

3:50 pm-9:27 pm

2 stops28h 37m

$577

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 4/15

7:02 pm-10:30 am

2 stops16h 28m

Panama City Tocumen Intl

Wed 4/22

5:30 am-8:58 am

2 stops26h 28m

$580

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 5/8

7:55 pm-2:55 pm

3 stops20h 00m

Panama City Tocumen Intl

Fri 5/15

3:50 pm-9:27 pm

2 stops28h 37m

$583

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 4/15

7:02 pm-2:55 pm

3 stops20h 53m

Panama City Tocumen Intl

Wed 4/22

5:30 am-8:58 am

2 stops26h 28m

$586

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 5/9

7:55 pm-10:30 am

2 stops15h 35m

Panama City Tocumen Intl

Sat 5/16

3:50 pm-9:31 am

2 stops16h 41m

$588

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 4/26

7:00 am-10:30 am

2 stops28h 30m

Panama City Tocumen Intl

Sat 5/2

3:50 pm-2:58 pm

2 stops22h 08m

$618

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 4/15

7:02 pm-2:55 pm

3 stops20h 53m

Panama City Tocumen Intl

Wed 4/22

11:25 am-8:58 am

3 stops20h 33m

$621

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Tue 9/22

5:52 pm-2:14 pm

2 stops21h 22m

Panama City Tocumen Intl

Fri 9/25

3:20 pm-9:49 am

2 stops17h 29m

$640

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 4/26

7:00 am-2:55 pm

3 stops32h 55m

Panama City Tocumen Intl

Sat 5/2

3:50 pm-9:30 am

2 stops16h 40m

$641

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Buffalo to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Buffalo to Panama flights?

You could potentially save up to 55% on your flight if you consider stops on a Buffalo to Panama flight.

Cheap Buffalo to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama

Fastest flight time

8h 53m

Direct flights

None
The fastest flight from Buffalo to Panama takes 8h 53m
There are no direct flights from Buffalo to Panama. There are no popular flight routes from Buffalo to Panama.
Search flight deals

  • When did momondo last update prices for flights from Buffalo Airport to Panama?

    Prices for flights from Buffalo Airport to Panama were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama?

  • How old do you have to be to fly from Buffalo Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Buffalo to Panama

Compare and see reviews for airlines that fly from Buffalo to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $461Free CancellationRating
7.9
8,359 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama from Buffalo.

Can I find flights from Buffalo to Panama with flexible booking policies on momondo?

Flights from Buffalo to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Buffalo.

I’m not ready to book a flight from Buffalo to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Buffalo. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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