What is the cheapest airline that flies from Buffalo to Panama?

American Airlines is the most popular carrier operating from Buffalo to Panama

When did momondo last update prices for flights from Buffalo Airport to Panama?

Prices for flights from Buffalo Airport to Panama were last updated today.

How many operators does momondo search for flights from Buffalo Airport to Panama?

As of November 2025, there is 1 operator available to choose from for flights from Buffalo Airport to Panama.

How old do you have to be to fly from Buffalo Airport to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to Panama.

What documentation or ID do you need to fly to Panama?

The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$232 Cheap Flights from Buffalo to Panama in 2025/26

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Cheap round-trip flights

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6:00 am - 1:55 pmBUF-PTY

7h 55m1 stop

3:20 pm - 11:28 pmPTY-BUF

8h 08m1 stop

$518Delta

Find Deal

Wed, Jan 21 - Thu, Jan 22

6:32 pm - 3:38 pmBUF-PTY

21h 06m2 stops

4:50 pm - 11:21 amPTY-BUF

18h 31m2 stops

$522American Airlines

Find Deal

Sat, Jan 17 - Fri, Jan 23

11:40 am - 7:31 pmBUF-PTY

8h 51m1 stop

7:55 am - 8:31 pmPTY-BUF

11h 36m2 stops

$529United Airlines

Find Deal

Mon, May 4 - Sat, May 9

6:00 am - 1:55 pmBUF-PTY

7h 55m1 stop

4:41 pm - 1:24 pmPTY-BUF

20h 43m2 stops

$549United Airlines

Find Deal

Mon, Jan 5 - Mon, Jan 12

6:00 am - 2:21 pmBUF-PTY

8h 21m1 stop

3:46 pm - 11:59 pmPTY-BUF

8h 13m1 stop

$564Delta

Find Deal

Fri, Dec 12 - Wed, Dec 17

11:24 am - 8:02 pmBUF-PTY

8h 38m1 stop

4:41 pm - 1:24 pmPTY-BUF

20h 43m2 stops

$568United Airlines

Find Deal

Sat, Jan 17 - Fri, Jan 23

7:32 pm - 3:15 pmBUF-PTY

19h 43m2 stops

3:13 pm - 11:54 amPTY-BUF

19h 41m2 stops

$572American Airlines

Find Deal

Sun, Mar 1 - Sun, Mar 15

11:29 am - 8:02 pmBUF-PTY

8h 33m1 stop

8:55 am - 11:44 pmPTY-BUF

14h 49m2 stops

$610United Airlines

Find Deal

Mon, Feb 23 - Wed, Mar 4

6:25 pm - 4:10 amBUF-PTY

10h 45m1 stop

10:55 pm - 9:48 amPTY-BUF

9h 53m1 stop

$625United Airlines

Find Deal

Sun, Mar 8 - Fri, Mar 13

11:24 am - 8:02 pmBUF-PTY

8h 38m1 stop

4:41 pm - 8:29 pmPTY-BUF

27h 48m2 stops

$632United Airlines

Find Deal

Fri, Jan 9 - Fri, Jan 16

American Airlines flights from Buffalo to Panama

Our best American Airlines deals on Buffalo to Panama flight tickets

American Airlines

Jan 17

BUF6:32 pmBuffalo

21h 06m

2 stops

PTY3:38 pmPanama City Tocumen Intl

Jan 23

PTY4:50 pmPanama City Tocumen Intl

18h 31m

2 stops

BUF11:21 amBuffalo

$522

Find similar

American Airlines

Mar 1

BUF7:32 pmBuffalo

19h 43m

2 stops

PTY3:15 pmPanama City Tocumen Intl

Mar 15

PTY3:13 pmPanama City Tocumen Intl

19h 41m

2 stops

BUF11:54 amBuffalo

$572

Find similar

American Airlines

Feb 23

BUF5:30 amBuffalo

9h 45m

2 stops

PTY3:15 pmPanama City Tocumen Intl

Mar 4

PTY2:50 pmPanama City Tocumen Intl

19h 54m

3 stops

BUF10:44 amBuffalo

$2,333

Find similar

Delta flights from Buffalo to Panama

Our best Delta deals on Buffalo to Panama flight tickets

Delta

Jan 21

BUF6:00 amBuffalo

7h 55m

1 stop

PTY1:55 pmPanama City Tocumen Intl

Jan 22

PTY3:20 pmPanama City Tocumen Intl

8h 08m

1 stop

BUF11:28 pmBuffalo

$518

Find similar

Delta

Dec 12

BUF6:00 amBuffalo

8h 21m

1 stop

PTY2:21 pmPanama City Tocumen Intl

Dec 17

PTY3:46 pmPanama City Tocumen Intl

8h 13m

1 stop

BUF11:59 pmBuffalo

$564

Find similar

Delta

Jan 5

BUF6:00 amBuffalo

7h 55m

1 stop

PTY1:55 pmPanama City Tocumen Intl

Jan 12

PTY3:20 pmPanama City Tocumen Intl

8h 36m

1 stop

BUF11:56 pmBuffalo

$864

Find similar

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 1/21

6:00 am-1:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Thu 1/22

3:20 pm-11:28 pm

1 stop8h 08m

$518

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 1/17

6:32 pm-3:38 pm

2 stops21h 06m

Panama City Tocumen Intl

Fri 1/23

4:50 pm-11:21 am

2 stops18h 31m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 5/4

11:40 am-7:31 pm

1 stop8h 51m

Panama City Tocumen Intl

Sat 5/9

7:55 am-8:31 pm

2 stops11h 36m

$529

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 1/5

6:00 am-1:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Mon 1/12

4:41 pm-1:24 pm

2 stops20h 43m

$549

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 12/12

6:00 am-2:21 pm

1 stop8h 21m

Panama City Tocumen Intl

Wed 12/17

3:46 pm-11:59 pm

1 stop8h 13m

$564

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 1/17

11:24 am-8:02 pm

1 stop8h 38m

Panama City Tocumen Intl

Fri 1/23

4:41 pm-1:24 pm

2 stops20h 43m

$568

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 3/1

7:32 pm-3:15 pm

2 stops19h 43m

Panama City Tocumen Intl

Sun 3/15

3:13 pm-11:54 am

2 stops19h 41m

$572

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 2/23

11:29 am-8:02 pm

1 stop8h 33m

Panama City Tocumen Intl

Wed 3/4

8:55 am-11:44 pm

2 stops14h 49m

$610

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 3/8

6:25 pm-4:10 am

1 stop10h 45m

Panama City Tocumen Intl

Fri 3/13

10:55 pm-9:48 am

1 stop9h 53m

$625

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 1/9

11:24 am-8:02 pm

1 stop8h 38m

Panama City Tocumen Intl

Fri 1/16

4:41 pm-8:29 pm

2 stops27h 48m

$632

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Panama?

According to our data, Friday is the cheapest day to fly to Panama from Buffalo. The lowest ticket price found for a Friday departure recently was $480. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Buffalo to Panama for around $760.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Buffalo to Panama when you can find flight prices for as low as $386. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $628 per ticket.

Can stopping save me money on Buffalo to Panama flights?

You could potentially save up to 58% on your flight if you consider stops on a Buffalo to Panama flight.

Cheap Buffalo to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama

Fastest flight time	7h 55m
Direct flights	None

The fastest flight from Buffalo to Panama takes 7h 55m

There are no direct flights from Buffalo to Panama. There are no popular flight routes from Buffalo to Panama.

Search flight deals

When did momondo last update prices for flights from Buffalo Airport to Panama?
Prices for flights from Buffalo Airport to Panama were last updated today.
How many operators does momondo search for flights from Buffalo Airport to Panama?
As of November 2025, there is 1 operator available to choose from for flights from Buffalo Airport to Panama.
How old do you have to be to fly from Buffalo Airport to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to Panama.
What documentation or ID do you need to fly to Panama?
The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Buffalo to Panama

Compare and see reviews for airlines that fly from Buffalo to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $486	Free Cancellation	Rating 7.9 7,999 reviews		Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama from Buffalo.

Can I find flights from Buffalo to Panama with flexible booking policies on momondo?

Flights from Buffalo to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Buffalo.

I’m not ready to book a flight from Buffalo to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Buffalo. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Find better results for your trip to Panama

Popular cities in Panama

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Flights to Changuinola

Cheap flights from Buffalo to Panama from $232

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama departing on 3/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Buffalo to Panama

Cheap round-trip flights

Cheap one-way flights

American Airlines flights from Buffalo to Panama

Our best American Airlines deals on Buffalo to Panama flight tickets

Delta flights from Buffalo to Panama

Our best Delta deals on Buffalo to Panama flight tickets

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Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

See travel insights to Panama from

How to get the cheapest flight ticket from Buffalo to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

Can stopping save me money on Buffalo to Panama flights?

You could potentially save up to 58% on your flight if you consider stops on a Buffalo to Panama flight.

What is the cheapest airline that flies from Buffalo to Panama?

American Airlines is the most popular carrier operating from Buffalo to Panama

Cheap Buffalo to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama

Fastest flight time

Direct flights

When did momondo last update prices for flights from Buffalo Airport to Panama?

How many operators does momondo search for flights from Buffalo Airport to Panama?

How old do you have to be to fly from Buffalo Airport to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from Buffalo to Panama

Compare and see reviews for airlines that fly from Buffalo to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama?

Can I find flights from Buffalo to Panama with flexible booking policies on momondo?

How can momondo help me find flights from Buffalo to Panama?

I’m not ready to book a flight from Buffalo to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo