Cheap flights from Brussels Bruxelles-National Airport to Chicago from $378

The month of September is, on average, the cheapest month to fly to Chicago from Brussels Bruxelles-National Airport, with most prices found around $559. If you’re not able to fly to Chicago in September, then November is your next best option. Flight prices from Brussels Bruxelles-National Airport to Chicago during November average around $559.

The cheapest day to depart on your flight to Chicago is on a Thursday when prices can be found for as low as $740. This is often the case because there is less demand to fly during this day of the week. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Brussels Bruxelles-National Airport to Chicago for around $842.

Fly from Brussels Bruxelles-National to Chicago O'Hare Intl for the best Brussels Bruxelles-National - Chicago flight prices

You are more likely to see cheaper flights to Chicago from Brussels Bruxelles-National Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $688 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Brussels Bruxelles-National Airport for as low as $604 on momondo.

There are 3 cabin classes available to choose from on Brussels Bruxelles-National to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 14% on your flight if you consider stops on a Brussels Bruxelles-National Airport to Chicago flight.

British Airways is the most popular carrier operating from Brussels Bruxelles-National to Chicago

United Airlines, Lufthansa and Brussels Airlines are the top three most popular airlines that fly to Chicago from Brussels Bruxelles-National Airport according to our data. United Airlines is the first choice among our users, with 57% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 3 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

Historically, on average around 14% of flights between Brussels and Chicago have experienced a delay on any given week. The average delay length over the past 12 months has been 166 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Air Antilles have had the least number of delays on this route over the last 12 months; with about 8% of their flights experiencing any sort of delay.

Amsterdam (AMS) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

Flights via Dublin (DUB) offer the lowest average round-trip price of $489.

Flights connecting via Amsterdam (AMS) have the shortest average one-way travel time: 10h 35m.

Reykjavik (KEF) has the shortest average layover time for this route: 1h 03m.

6 flights are operational daily from Brussels Bruxelles-National Airport to Chicago as of February 2026. The most popular departure time for this route is 10:00AM, with 100% of flights per day taking off at noon.

42 flights are operational weekly from Brussels Bruxelles-National Airport to Chicago as of February 2026. The most popular departure day for this route is Mon, with 14% of flights per week taking off on this day.