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Cheap flights from Amarillo to Knoxville from $375

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Amarillo to Knoxville departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Amarillo to Knoxville (AMA-TYS)

Cheap round-trip flights

American Airlines Logo
4:26 pm - 12:21 amAMA-TYS
6h 55m1 stop
American Airlines Logo
6:22 pm - 11:57 pmTYS-AMA
6h 35m1 stop
$375American Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10
American Airlines Logo
2:16 pm - 11:03 pmAMA-TYS
7h 47m2 stops
American Airlines Logo
6:22 pm - 11:57 pmTYS-AMA
6h 35m1 stop
$380American Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10
United Airlines Logo
12:05 pm - 7:52 pmAMA-TYS
6h 47m1 stop
United Airlines Logo
7:15 am - 2:09 pmTYS-AMA
7h 54m1 stop
$397United Airlines
Find Deal
Tue, Oct 21 - Thu, Oct 23
American Airlines Logo
12:36 pm - 11:07 pmAMA-TYS
9h 31m2 stops
American Airlines Logo
6:22 pm - 10:49 pmTYS-AMA
5h 27m1 stop
$402American Airlines
Find Deal
Tue, Oct 21 - Thu, Oct 23
American Airlines Logo
12:36 pm - 11:07 pmAMA-TYS
9h 31m2 stops
American Airlines Logo
10:02 am - 5:51 pmTYS-AMA
8h 49m2 stops
$407American Airlines
Find Deal
Tue, Oct 21 - Thu, Oct 23
American Airlines Logo
2:06 pm - 11:50 pmAMA-TYS
8h 44m2 stops
American Airlines Logo
5:00 am - 1:36 pmTYS-AMA
9h 36m2 stops
$412American Airlines
Find Deal
Mon, Oct 6 - Sat, Oct 11
American Airlines Logo
7:57 am - 3:23 pmAMA-TYS
6h 26m1 stop
American Airlines Logo
5:51 am - 9:26 amTYS-AMA
4h 35m1 stop
$423American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:35 pm - 11:40 pmAMA-TYS
4h 05m1 stop
American Airlines Logo
11:03 am - 8:07 pmTYS-AMA
10h 04m2 stops
$428American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
2:06 pm - 11:50 pmAMA-TYS
8h 44m2 stops
American Airlines Logo
6:47 pm - 11:13 pmTYS-AMA
5h 26m1 stop
$441American Airlines
Find Deal
Mon, Oct 6 - Sat, Oct 11
United Airlines Logo
8:00 am - 7:52 pmAMA-TYS
10h 52m2 stops
United Airlines Logo
2:00 pm - 10:12 pmTYS-AMA
9h 12m2 stops
$455United Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10

American Airlines flights from Amarillo to Knoxville

Our best American Airlines deals on Amarillo to Knoxville flight tickets
American Airlines
Oct 4
AMA4:26 pmAmarillo
6h 55m
1 stop
TYS12:21 amKnoxville McGhee Tyson
Oct 10
TYS6:22 pmKnoxville McGhee Tyson
6h 35m
1 stop
AMA11:57 pmAmarillo
$375
Find similar
American Airlines
Oct 4
AMA2:16 pmAmarillo
7h 47m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Oct 10
TYS6:22 pmKnoxville McGhee Tyson
6h 35m
1 stop
AMA11:57 pmAmarillo
$380
Find similar
American Airlines
Oct 21
AMA12:36 pmAmarillo
9h 31m
2 stops
TYS11:07 pmKnoxville McGhee Tyson
Oct 23
TYS6:22 pmKnoxville McGhee Tyson
5h 27m
1 stop
AMA10:49 pmAmarillo
$402
Find similar

United Airlines flights from Amarillo to Knoxville

Our best United Airlines deals on Amarillo to Knoxville flight tickets
United Airlines
Oct 21
AMA12:05 pmAmarillo
6h 47m
1 stop
TYS7:52 pmKnoxville McGhee Tyson
Oct 23
TYS7:15 amKnoxville McGhee Tyson
7h 54m
1 stop
AMA2:09 pmAmarillo
$397
Find similar
United Airlines
Oct 4
AMA8:00 amAmarillo
10h 52m
2 stops
TYS7:52 pmKnoxville McGhee Tyson
Oct 10
TYS2:00 pmKnoxville McGhee Tyson
9h 12m
2 stops
AMA10:12 pmAmarillo
$455
Find similar
United Airlines
Oct 6
AMA5:27 pmAmarillo
16h 02m
2 stops
TYS10:29 amKnoxville McGhee Tyson
Oct 11
TYS8:50 amKnoxville McGhee Tyson
9h 02m
2 stops
AMA4:52 pmAmarillo
$495
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Amarillo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Amarillo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Sat 10/4

4:26 pm-12:21 am

1 stop6h 55m

Knoxville McGhee Tyson

Fri 10/10

6:22 pm-11:57 pm

1 stop6h 35m

$375

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Sat 10/4

2:16 pm-11:03 pm

2 stops7h 47m

Knoxville McGhee Tyson

Fri 10/10

6:22 pm-11:57 pm

1 stop6h 35m

$380

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Tue 10/21

12:05 pm-7:52 pm

1 stop6h 47m

Knoxville McGhee Tyson

Thu 10/23

7:15 am-2:09 pm

1 stop7h 54m

$397

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Tue 10/21

12:36 pm-11:07 pm

2 stops9h 31m

Knoxville McGhee Tyson

Thu 10/23

6:22 pm-10:49 pm

1 stop5h 27m

$402

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Tue 10/21

12:36 pm-11:07 pm

2 stops9h 31m

Knoxville McGhee Tyson

Thu 10/23

10:02 am-5:51 pm

2 stops8h 49m

$407

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Mon 10/6

2:06 pm-11:50 pm

2 stops8h 44m

Knoxville McGhee Tyson

Sat 10/11

5:00 am-1:36 pm

2 stops9h 36m

$412

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Sat 2/21

7:57 am-3:23 pm

1 stop6h 26m

Knoxville McGhee Tyson

Wed 2/25

5:51 am-9:26 am

1 stop4h 35m

$423

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Sat 2/21

6:35 pm-11:40 pm

1 stop4h 05m

Knoxville McGhee Tyson

Wed 2/25

11:03 am-8:07 pm

2 stops10h 04m

$428

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Mon 10/6

2:06 pm-11:50 pm

2 stops8h 44m

Knoxville McGhee Tyson

Sat 10/11

6:47 pm-11:13 pm

1 stop5h 26m

$441

AmarilloKnoxville

AMA - TYS

AMATYS

Amarillo

Sat 10/4

8:00 am-7:52 pm

2 stops10h 52m

Knoxville McGhee Tyson

Fri 10/10

2:00 pm-10:12 pm

2 stops9h 12m

$455

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Amarillo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Amarillo and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Amarillo, with most prices found around $258. If you aren’t able to travel during the month of January, then book flights to Knoxville from Amarillo during February instead. Flights to Knoxville in February, while not as cheap as those in January, still average around $258.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Amarillo to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $317. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Amarillo to Knoxville for around $559.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Amarillo to Knoxville when you can find flight prices for as low as $393. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $500.

When to book flights from Amarillo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Amarillo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Amarillo to Knoxville (AMA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Amarillo to Knoxville

Direct flights

None
There are no direct flights from Amarillo to Knoxville. There are no popular flight routes from Amarillo to Knoxville.
Search flight deals

  • How far is Amarillo to Knoxville McGhee Tyson by plane?

    The distance between Amarillo and Knoxville McGhee Tyson is about 1005.4 mi. 4h 05m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Amarillo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Amarillo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Amarillo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Amarillo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Amarillo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Amarillo to Knoxville?

Best airlines flying from Amarillo to Knoxville

Compare and see reviews for airlines that fly from Amarillo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Amarillo to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Amarillo.

Can I find flights from Amarillo to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Amarillo on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Amarillo to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Amarillo.

I’m not ready to book a flight from Amarillo to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Amarillo to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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