Cheap flights from Florence, South Carolina (FLO) from $289

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Fly to

Route

Depart

Return

Price

Cheapest one-way

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 6/10

2:35 pm-7:45 pm

1 stop6h 10m

$170

Quickest one-way

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 5/26

5:05 am-9:02 am

1 stop4h 57m

$218

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 5/27

2:35 pm-10:10 pm

2 stops8h 35m

$223

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 5/29

5:05 am-9:02 am

1 stop4h 57m

$230

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 5/31

2:35 pm-7:48 pm

1 stop6h 13m

$235

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 6/7

2:35 pm-7:45 pm

1 stop6h 10m

$252

FlorenceBoston

FLO - BOS

FLOBOS

Florence

Wed 6/17

5:05 am-11:11 am

1 stop6h 06m

$252

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 6/7

5:05 am-2:01 pm

2 stops9h 56m

$257

FlorenceBoston

FLO - BOS

FLOBOS

Florence

Wed 6/17

2:35 pm-10:28 pm

2 stops7h 53m

$257

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/28

2:35 pm-6:14 am

2 stops16h 39m

$363

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Florence, South Carolina?

Currently, destinations can be reached directly via flights from Florence, South Carolina.

Find the cheapest flights from Florence, South Carolina

One-way

Last minute

International

Domestic

Cheap one-way flights from Florence, South Carolina

Enter your travel dates to find the best prices.

2:35 pm - 7:45 pm

FLO

ORD

6h 10m

1 stop

$170American Airlines

Wed, Jun 10

5:05 am - 9:02 am

FLO

ORD

4h 57m

1 stop

$218American Airlines

Tue, May 26

2:35 pm - 10:10 pm

FLO

ORD

8h 35m

2 stops

$223American Airlines

Wed, May 27

5:05 am - 9:02 am

FLO

ORD

4h 57m

1 stop

$230American Airlines

Fri, May 29

2:35 pm - 7:48 pm

FLO

ORD

6h 13m

1 stop

$235American Airlines

Sun, May 31

2:35 pm - 7:45 pm

FLO

ORD

6h 10m

1 stop

$252American Airlines

Sun, Jun 7

5:05 am - 11:11 am

FLO

BOS

6h 06m

1 stop

$252American Airlines

Wed, Jun 17

5:05 am - 2:01 pm

FLO

ORD

9h 56m

2 stops

$257American Airlines

Sun, Jun 7

2:35 pm - 10:28 pm

FLO

BOS

7h 53m

2 stops

$257American Airlines

Wed, Jun 17

2:35 pm - 6:14 am

FLO

ORD

16h 39m

2 stops

$363American Airlines

Thu, May 28

Flights from Florence, South Carolina - Travel Insights & Trends

Get data-powered insights and trends into flights from Florence, South Carolina to help you craft the best travel plan.

Prices

Other information

Frequently asked questions regarding flights from Florence, South Carolina

Which airlines are currently offering the cheapest flights from Florence, South Carolina?

Our data suggests that currently, the cheapest flights from Florence, South Carolina are being offered by American Airlines. For example, American Airlines flights from Florence, South Carolina to Chicago O'Hare Intl Airport start at $176.

What is the cheapest flight available from Florence, South Carolina?

Currently, the cheapest flight from Florence, South Carolina found by our users is for $172 to Charlotte. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $495 to travel from Florence, South Carolina to Charlotte.

Which destinations have the most frequent flights from Florence, South Carolina?

Charlotte is currently the destination served most frequently from Florence, South Carolina, with 2 flights per day on average.

Which airlines can you fly with from Florence, South Carolina?

Airlines including American Airlines frequently fly from Florence, South Carolina. You can view other airlines by performing a quick search in the form above.

When did momondo last update prices for flights from Florence Airport?

Prices for flights from Florence Airport were last updated today.

How many operators does momondo search for flights from Florence Airport?

The number of operators available for flights from Florence Airport is 1 as of April 2026.

How old do you have to be to fly from Florence Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport.

What documentation or ID do you need to fly to Florence Airport?

The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.