Cheap flights from Florence, South Carolina (FLO) from $274

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Fly to

Route

Depart

Return

Price

Cheapest one-way

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Sun 10/4

5:09 am-9:00 am

1 stop4h 51m

$274

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Mon 10/5

2:34 pm-7:51 pm

1 stop6h 17m

$274

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Sun 10/4

5:09 am-10:45 am

1 stop6h 36m

$274

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Mon 10/5

2:34 pm-5:51 pm

1 stop4h 17m

$274

FlorenceMiami

FLO Florence - MIA Miami

FLOMIA

Florence

Thu 12/31

2:35 pm-9:54 pm

2 stops7h 19m

$389

FlorenceDallas

FLO Florence - DFW Dallas/Fort Worth

FLODFW

Florence

Wed 10/14

2:34 pm-9:44 pm

1 stop8h 10m

$397

FlorenceNew York

FLO Florence - LGA New York LaGuardia

FLOLGA

Florence

Sat 9/26

1:43 pm-7:52 pm

1 stop6h 09m

$402

Quickest one-way

FlorenceOrlando

FLO Florence - MCO Orlando

FLOMCO

Florence

Sat 9/26

6:24 am-10:17 am

1 stop3h 53m

$417

FlorenceOrlando

FLO Florence - MCO Orlando

FLOMCO

Florence

Sat 9/26

1:43 pm-6:31 pm

1 stop4h 48m

$417

FlorenceNew York

FLO Florence - LGA New York LaGuardia

FLOLGA

Florence

Sat 9/26

6:24 am-3:28 pm

2 stops9h 04m

$435

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Florence, South Carolina?

Currently, destinations can be reached directly via flights from Florence, South Carolina.

Find the cheapest flights from Florence, South Carolina

One-way

Last minute

International

Domestic

Cheap one-way flights from Florence, South Carolina

Enter your travel dates to find the best prices.

5:09 am - 9:00 amFLO Florence-ORD Chicago O'Hare Intl

4h 51m1 stop Charlotte Douglas

$274American Airlines

Sun, Oct 4

2:34 pm - 7:51 pmFLO Florence-ORD Chicago O'Hare Intl

6h 17m1 stop Charlotte Douglas

$274American Airlines

Mon, Oct 5

5:09 am - 10:45 amFLO Florence-ORD Chicago O'Hare Intl

6h 36m1 stop Charlotte Douglas

$274American Airlines

Sun, Oct 4

2:34 pm - 5:51 pmFLO Florence-ORD Chicago O'Hare Intl

4h 17m1 stop Charlotte Douglas

$274American Airlines

Mon, Oct 5

2:35 pm - 9:54 pmFLO Florence-MIA Miami

7h 19m2 stops Charlotte Douglas New Orleans Louis Armstrong

$389American Airlines

Thu, Dec 31

2:34 pm - 9:44 pmFLO Florence-DFW Dallas/Fort Worth

8h 10m1 stop Charlotte Douglas

$397American Airlines

Wed, Oct 14

1:43 pm - 7:52 pmFLO Florence-LGA New York LaGuardia

6h 09m1 stop Charlotte Douglas

$402American Airlines

Sat, Sep 26

6:24 am - 10:17 amFLO Florence-MCO Orlando

3h 53m1 stop Charlotte Douglas

$417American Airlines

Sat, Sep 26

1:43 pm - 6:31 pmFLO Florence-MCO Orlando

4h 48m1 stop Charlotte Douglas

$417American Airlines

Sat, Sep 26

6:24 am - 3:28 pmFLO Florence-LGA New York LaGuardia

9h 04m2 stops Charlotte Douglas Washington, D.C. Reagan-National

$435American Airlines

Sat, Sep 26

Last-minute flight deals from Florence, South Carolina

Enter your travel dates to find the best prices.

6:24 am - 10:04 amFLO Florence-IAH Houston George Bush Intcntl

4h 40m1 stop Charlotte Douglas

5:24 pm - 11:57 pmIAH Houston George Bush Intcntl-FLO Florence

5h 33m1 stop Charlotte Douglas

$509American Airlines

Fri, Sep 25 - Sun, Sep 27

1:43 pm - 7:24 pmFLO Florence-IAH Houston George Bush Intcntl

6h 41m1 stop Charlotte Douglas

5:24 pm - 11:57 pmIAH Houston George Bush Intcntl-FLO Florence

5h 33m1 stop Charlotte Douglas

$534American Airlines

Wed, Sep 23 - Sun, Sep 27

1:43 pm - 6:56 pmFLO Florence-DFW Dallas/Fort Worth

6h 13m1 stop Charlotte Douglas

4:01 pm - 10:58 pmDFW Dallas/Fort Worth-FLO Florence

5h 57m1 stop Charlotte Douglas

$545American Airlines

Tue, Sep 22 - Sat, Sep 26

1:43 pm - 6:56 pmFLO Florence-DFW Dallas/Fort Worth

6h 13m1 stop Charlotte Douglas

7:00 am - 1:18 pmDFW Dallas/Fort Worth-FLO Florence

5h 18m1 stop Charlotte Douglas

$548American Airlines

Tue, Sep 22 - Sat, Sep 26

1:43 pm - 8:00 pmFLO Florence-JFK New York John F Kennedy Intl

6h 17m1 stop Charlotte Douglas

7:59 am - 2:10 pmJFK New York John F Kennedy Intl-FLO Florence

6h 11m1 stop Charlotte Douglas

$616American Airlines

Sat, Sep 26 - Sun, Sep 27

6:24 am - 11:05 amFLO Florence-LGA New York LaGuardia

4h 41m1 stop Charlotte Douglas

9:59 am - 2:10 pmLGA New York LaGuardia-FLO Florence

4h 11m1 stop Charlotte Douglas

$616American Airlines

Sat, Sep 26 - Sun, Sep 27

6:24 am - 12:40 pmFLO Florence-EWR Newark

6h 16m1 stop Charlotte Douglas

7:37 am - 2:10 pmEWR Newark-FLO Florence

6h 33m1 stop Charlotte Douglas

$616American Airlines

Sat, Sep 26 - Sun, Sep 27

6:24 am - 1:01 pmFLO Florence-DFW Dallas/Fort Worth

7h 37m1 stop Charlotte Douglas

7:00 am - 1:18 pmDFW Dallas/Fort Worth-FLO Florence

5h 18m1 stop Charlotte Douglas

$640American Airlines

Thu, Sep 24 - Tue, Sep 29

2:36 pm - 8:59 pmFLO Florence-MCO Orlando

6h 23m1 stop Charlotte Douglas

8:03 am - 1:18 pmMCO Orlando-FLO Florence

5h 15m1 stop Charlotte Douglas

$665American Airlines

Sun, Sep 27 - Thu, Oct 1

1:43 pm - 8:39 pmFLO Florence-MIA Miami

6h 56m1 stop Charlotte Douglas

8:52 am - 1:18 pmMIA Miami-FLO Florence

4h 26m1 stop Charlotte Douglas

$671American Airlines

Fri, Sep 25 - Mon, Sep 28

Cheapest international flights from Florence, South Carolina

Enter your travel dates to find the best prices.

6:24 am - 1:07 pmFLO Florence-SJO San José Juan Santamaria Intl

7h 43m1 stop Charlotte Douglas

2:07 pm - 10:59 pmSJO San José Juan Santamaria Intl-FLO Florence

7h 52m1 stop Charlotte Douglas

$683American Airlines

Wed, Nov 4 - Wed, Nov 11

6:24 am - 8:50 pmFLO Florence-SJO San José Juan Santamaria Intl

15h 26m2 stops Charlotte Douglas Miami

2:46 pm - 2:10 pmSJO San José Juan Santamaria Intl-FLO Florence

22h 24m2 stops Dallas/Fort Worth Charlotte Douglas

$688American Airlines

Wed, Nov 4 - Wed, Nov 11

5:09 am - 8:21 pmFLO Florence-SJO San José Juan Santamaria Intl

17h 12m2 stops Charlotte Douglas Miami

6:00 am - 11:57 pmSJO San José Juan Santamaria Intl-FLO Florence

15h 57m2 stops Miami Charlotte Douglas

$798American Airlines

Wed, Oct 21 - Sun, Oct 25

2:35 pm - 10:46 amFLO Florence-CUN Cancun

20h 11m2 stops Charlotte Douglas Miami

5:32 pm - 3:09 pmCUN Cancun-FLO Florence

21h 37m2 stops Miami Charlotte Douglas

$809American Airlines

Sun, Nov 1 - Sun, Nov 8

2:35 pm - 4:10 pmFLO Florence-CUN Cancun

25h 35m1 stop Charlotte Douglas

5:32 pm - 3:09 pmCUN Cancun-FLO Florence

21h 37m2 stops Miami Charlotte Douglas

$815American Airlines

Sun, Nov 1 - Sun, Nov 8

2:34 pm - 12:00 pmFLO Florence-SJO San José Juan Santamaria Intl

23h 26m2 stops Charlotte Douglas Miami

6:00 am - 11:57 pmSJO San José Juan Santamaria Intl-FLO Florence

15h 57m2 stops Miami Charlotte Douglas

$828American Airlines

Wed, Oct 21 - Sun, Oct 25

3:44 pm - 9:40 amFLO Florence-LHR London Heathrow

12h 56m1 stop Charlotte Douglas

11:45 am - 10:59 pmLHR London Heathrow-FLO Florence

16h 14m1 stop Charlotte Douglas

$894American Airlines

Tue, Nov 3 - Tue, Nov 10

3:44 pm - 10:25 amFLO Florence-LHR London Heathrow

13h 41m2 stops Charlotte Douglas Chicago O'Hare Intl

11:20 am - 10:59 pmLHR London Heathrow-FLO Florence

16h 39m2 stops New York John F Kennedy Intl Charlotte Douglas

$898American Airlines

Tue, Nov 3 - Tue, Nov 10

3:37 pm - 2:55 pmFLO Florence-FCO Rome Fiumicino

17h 18m2 stops Charlotte Douglas London Heathrow

11:00 am - 10:59 pmFCO Rome Fiumicino-FLO Florence

17h 59m2 stops Philadelphia Charlotte Douglas

$904American Airlines

Mon, Nov 2 - Mon, Nov 9

8:00 am - 9:14 pmFLO Florence-CUN Cancun

13h 14m2 stops Charlotte Douglas Dallas/Fort Worth

11:22 am - 11:54 pmCUN Cancun-FLO Florence

12h 32m1 stop Charlotte Douglas

$930American Airlines

Thu, Nov 26 - Sun, Nov 29

Cheapest domestic flights from Florence, South Carolina

Enter your travel dates to find the best prices.

5:09 am - 8:58 amFLO Florence-IAH Houston George Bush Intcntl

4h 49m1 stop Charlotte Douglas

8:19 am - 2:09 pmIAH Houston George Bush Intcntl-FLO Florence

4h 50m1 stop Charlotte Douglas

$359American Airlines

Wed, Oct 21 - Sun, Oct 25

3:37 pm - 10:29 pmFLO Florence-JFK New York John F Kennedy Intl

6h 52m1 stop Charlotte Douglas

7:59 am - 2:09 pmJFK New York John F Kennedy Intl-FLO Florence

6h 10m1 stop Charlotte Douglas

$440American Airlines

Wed, Nov 18 - Mon, Nov 23

3:37 pm - 8:29 pmFLO Florence-EWR Newark

4h 52m1 stop Charlotte Douglas

9:30 am - 2:09 pmEWR Newark-FLO Florence

4h 39m1 stop Charlotte Douglas

$440American Airlines

Wed, Nov 18 - Mon, Nov 23

5:09 am - 11:19 amFLO Florence-LGA New York LaGuardia

6h 10m1 stop Charlotte Douglas

5:00 pm - 10:59 pmLGA New York LaGuardia-FLO Florence

5h 59m1 stop Charlotte Douglas

$440American Airlines

Wed, Oct 28 - Mon, Nov 2

2:35 pm - 9:13 pmFLO Florence-IAH Houston George Bush Intcntl

7h 38m1 stop Charlotte Douglas

3:21 pm - 11:57 pmIAH Houston George Bush Intcntl-FLO Florence

7h 36m1 stop Charlotte Douglas

$459American Airlines

Tue, Dec 1 - Wed, Dec 23

2:35 pm - 8:33 pmFLO Florence-IAH Houston George Bush Intcntl

6h 58m1 stop Charlotte Douglas

5:52 pm - 11:54 pmIAH Houston George Bush Intcntl-FLO Florence

5h 02m1 stop Charlotte Douglas

$469American Airlines

Sat, Nov 21 - Mon, Nov 23

5:09 am - 11:45 amFLO Florence-MCO Orlando

6h 36m1 stop Charlotte Douglas

10:02 am - 2:09 pmMCO Orlando-FLO Florence

4h 07m1 stop Charlotte Douglas

$477American Airlines

Sat, Oct 17 - Wed, Oct 21

2:35 pm - 9:10 pmFLO Florence-IAH Houston George Bush Intcntl

7h 35m1 stop Charlotte Douglas

10:33 am - 10:59 pmIAH Houston George Bush Intcntl-FLO Florence

11h 26m2 stops Dallas/Fort Worth Charlotte Douglas

$483American Airlines

Thu, Dec 10 - Mon, Dec 14

1:43 pm - 5:38 pmFLO Florence-ORD Chicago O'Hare Intl

4h 55m1 stop Charlotte Douglas

6:29 am - 2:09 pmORD Chicago O'Hare Intl-FLO Florence

6h 40m1 stop Charlotte Douglas

$489American Airlines

Sat, Oct 3 - Wed, Oct 7

6:24 am - 10:29 amFLO Florence-JFK New York John F Kennedy Intl

4h 05m1 stop Charlotte Douglas

5:06 pm - 11:12 pmJFK New York John F Kennedy Intl-FLO Florence

6h 06m1 stop Charlotte Douglas

$491American Airlines

Sat, Oct 3 - Tue, Oct 6

Flights from Florence, South Carolina - Travel Insights & Trends

Get data-powered insights and trends into flights from Florence, South Carolina to help you craft the best travel plan.

Prices

Other information

Frequently asked questions regarding flights from Florence, South Carolina

Which airlines are currently offering the cheapest flights from Florence, South Carolina?

Our data suggests that currently, the cheapest flights from Florence, South Carolina are being offered by American Airlines. For example, American Airlines flights from Florence, South Carolina to Houston George Bush Intcntl Airport start at $308.

What is the cheapest flight available from Florence, South Carolina?

Currently, the cheapest flight from Florence, South Carolina found by our users is for $303 to Charlotte. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $635 to travel from Florence, South Carolina to Charlotte.

Which destinations have the most frequent flights from Florence, South Carolina?

Charlotte is currently the destination served most frequently from Florence, South Carolina, with 2 flights per day on average.

Which airlines can you fly with from Florence, South Carolina?

Airlines including American Airlines frequently fly from Florence, South Carolina. You can view other airlines by performing a quick search in the form above.

When did momondo last update prices for flights from Florence Airport?

Prices for flights from Florence Airport were last updated today.

How many operators does momondo search for flights from Florence Airport?

The number of operators available for flights from Florence Airport is 1 as of September 2026.

How old do you have to be to fly from Florence Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport.

What documentation or ID do you need to fly to Florence Airport?

The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.