Cheap flights from Florence, South Carolina (FLO) from $255

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Route

Depart

Return

Price

Cheapest one-way

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Sat 3/13

5:09 am-9:00 am

1 stop4h 51m

$255

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Fri 4/2

5:09 am-9:00 am

1 stop4h 51m

$320

FlorenceDallas

FLO Florence - DFW Dallas/Fort Worth

FLODFW

Florence

Wed 12/9

6:24 am-11:12 am

1 stop5h 48m

$402

FlorencePhoenix

FLO Florence - PHX Phoenix Sky Harbor Intl

FLOPHX

Florence

Wed 2/3

4:03 pm-8:55 pm

1 stop6h 52m

$444

FlorencePhoenix

FLO Florence - PHX Phoenix Sky Harbor Intl

FLOPHX

Florence

Wed 2/3

6:24 am-3:19 pm

2 stops10h 55m

$469

FlorenceNashville

FLO Florence - BNA Nashville Intl

FLOBNA

Florence

Thu 11/5

5:09 am-8:05 am

1 stop3h 56m

$470

FlorenceNashville

FLO Florence - BNA Nashville Intl

FLOBNA

Florence

Thu 11/5

2:35 pm-10:04 pm

2 stops8h 29m

$498

FlorenceFort Lauderdale

FLO Florence - FLL Fort Lauderdale

FLOFLL

Florence

Sat 12/26

2:35 pm-12:20 am

1 stop9h 45m

$518

FlorenceChicago

FLO Florence - ORD Chicago O'Hare Intl

FLOORD

Florence

Fri 4/2

5:09 am-1:06 pm

2 stops8h 57m

$669

Quickest one-way

FlorenceFort Lauderdale

FLO Florence - FLL Fort Lauderdale

FLOFLL

Florence

Sat 12/26

2:35 pm-6:29 pm

1 stop3h 54m

$671

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Florence, South Carolina?

Currently, destinations can be reached directly via flights from Florence, South Carolina.

Find the cheapest flights from Florence, South Carolina

One-way

Last minute

International

Domestic

Cheap one-way flights from Florence, South Carolina

Enter your travel dates to find the best prices.

5:09 am - 9:00 amFLO Florence-ORD Chicago O'Hare Intl

4h 51m1 stop Charlotte Douglas

$255American Airlines

Sat, Mar 13

5:09 am - 9:00 amFLO Florence-ORD Chicago O'Hare Intl

4h 51m1 stop Charlotte Douglas

$320American Airlines

Fri, Apr 2

6:24 am - 11:12 amFLO Florence-DFW Dallas/Fort Worth

5h 48m1 stop Charlotte Douglas

$402American Airlines

Wed, Dec 9

4:03 pm - 8:55 pmFLO Florence-PHX Phoenix Sky Harbor Intl

6h 52m1 stop Charlotte Douglas

$444American Airlines

Wed, Feb 3

6:24 am - 3:19 pmFLO Florence-PHX Phoenix Sky Harbor Intl

10h 55m2 stops Charlotte Douglas Dallas/Fort Worth

$469American Airlines

Wed, Feb 3

5:09 am - 8:05 amFLO Florence-BNA Nashville Intl

3h 56m1 stop Charlotte Douglas

$470American Airlines

Thu, Nov 5

2:35 pm - 10:04 pmFLO Florence-BNA Nashville Intl

8h 29m2 stops Charlotte Douglas Miami

$498American Airlines

Thu, Nov 5

2:35 pm - 12:20 amFLO Florence-FLL Fort Lauderdale

9h 45m1 stop Charlotte Douglas

$518American Airlines

Sat, Dec 26

5:09 am - 1:06 pmFLO Florence-ORD Chicago O'Hare Intl

8h 57m2 stops Charlotte Douglas Indianapolis

$669American Airlines

Fri, Apr 2

2:35 pm - 6:29 pmFLO Florence-FLL Fort Lauderdale

3h 54m1 stop Charlotte Douglas

$671American Airlines

Sat, Dec 26

Last-minute flight deals from Florence, South Carolina

Enter your travel dates to find the best prices.

2:34 pm - 5:51 pmFLO Florence-ORD Chicago O'Hare Intl

4h 17m1 stop Charlotte Douglas

6:41 am - 2:09 pmORD Chicago O'Hare Intl-FLO Florence

6h 28m1 stop Charlotte Douglas

$457American Airlines

Wed, Oct 28 - Fri, Nov 27

2:34 pm - 7:51 pmFLO Florence-ORD Chicago O'Hare Intl

6h 17m1 stop Charlotte Douglas

6:49 pm - 11:54 pmORD Chicago O'Hare Intl-FLO Florence

4h 05m1 stop Charlotte Douglas

$475American Airlines

Wed, Oct 28 - Fri, Nov 27

5:09 am - 11:13 amFLO Florence-DFW Dallas/Fort Worth

7h 04m1 stop Charlotte Douglas

8:30 am - 3:16 pmDFW Dallas/Fort Worth-FLO Florence

5h 46m1 stop Charlotte Douglas

$510American Airlines

Fri, Oct 30 - Tue, Nov 3

2:34 pm - 6:54 pmFLO Florence-FLL Fort Lauderdale

4h 20m1 stop Charlotte Douglas

5:30 pm - 11:56 pmFLL Fort Lauderdale-FLO Florence

6h 26m1 stop Charlotte Douglas

$529American Airlines

Fri, Oct 30 - Sun, Nov 1

2:34 pm - 7:51 pmFLO Florence-ORD Chicago O'Hare Intl

6h 17m1 stop Charlotte Douglas

6:41 am - 2:09 pmORD Chicago O'Hare Intl-FLO Florence

6h 28m1 stop Charlotte Douglas

$555American Airlines

Wed, Oct 28 - Sat, Nov 28

2:34 pm - 5:51 pmFLO Florence-ORD Chicago O'Hare Intl

4h 17m1 stop Charlotte Douglas

3:22 pm - 11:54 pmORD Chicago O'Hare Intl-FLO Florence

7h 32m2 stops Philadelphia Charlotte Douglas

$625American Airlines

Wed, Oct 28 - Fri, Nov 27

2:34 pm - 7:51 pmFLO Florence-ORD Chicago O'Hare Intl

6h 17m1 stop Charlotte Douglas

6:29 am - 2:09 pmORD Chicago O'Hare Intl-FLO Florence

6h 40m2 stops Philadelphia Charlotte Douglas

$654American Airlines

Wed, Oct 28 - Sat, Nov 28

2:34 pm - 8:08 pmFLO Florence-DFW Dallas/Fort Worth

6h 34m1 stop Charlotte Douglas

3:35 pm - 10:59 pmDFW Dallas/Fort Worth-FLO Florence

6h 24m2 stops Memphis Charlotte Douglas

$875American Airlines

Fri, Oct 30 - Tue, Nov 3

3:19 pm - 8:30 pmFLO Florence-JFK New York John F Kennedy Intl

5h 11m1 stop Charlotte Douglas

5:06 pm - 11:57 pmJFK New York John F Kennedy Intl-FLO Florence

6h 51m1 stop Charlotte Douglas

$876American Airlines

Tue, Oct 27 - Thu, Oct 29

3:19 pm - 8:00 pmFLO Florence-LGA New York LaGuardia

4h 41m1 stop Charlotte Douglas

5:12 pm - 11:57 pmLGA New York LaGuardia-FLO Florence

6h 45m1 stop Charlotte Douglas

$876American Airlines

Tue, Oct 27 - Thu, Oct 29

Cheapest international flights from Florence, South Carolina

Enter your travel dates to find the best prices.

6:05 pm - 7:20 amCAE Columbia Metropolitan-MAD Madrid Barajas

31h 15m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl

9:20 am - 8:12 pmMAD Madrid Barajas-CAE Columbia Metropolitan

16h 52m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson

$699Virgin Atlantic

Sun, Nov 29 - Tue, Dec 8

5:34 pm - 7:20 amCHS Charleston-MAD Madrid Barajas

31h 46m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl

9:20 am - 7:22 pmMAD Madrid Barajas-CHS Charleston

16h 02m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson

$701Virgin Atlantic

Mon, Nov 23 - Tue, Dec 8

11:53 am - 7:20 amCAE Columbia Metropolitan-MAD Madrid Barajas

37h 27m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl

12:20 pm - 8:12 pmMAD Madrid Barajas-CAE Columbia Metropolitan

13h 52m1 stop Atlanta Hartsfield-Jackson

$705Virgin Atlantic

Sun, Nov 29 - Tue, Dec 8

5:10 pm - 1:05 pmCLT Charlotte Douglas-IST Istanbul

36h 55m2 stops Toronto Pearson Intl Frankfurt am Main

3:45 am - 4:45 pmIST Istanbul-CLT Charlotte Douglas

20h 00m1 stop Munich Franz Josef Strauss

$721Multiple Airlines

Sat, Apr 17 - Mon, Apr 26

8:55 am - 6:10 pmCLT Charlotte Douglas-IST Istanbul

25h 15m2 stops Toronto Pearson Intl Frankfurt am Main

6:30 am - 9:06 pmIST Istanbul-CLT Charlotte Douglas

22h 36m2 stops Frankfurt am Main Toronto Pearson Intl

$729Multiple Airlines

Sun, Jan 31 - Thu, Feb 4

2:42 pm - 2:10 pmCHS Charleston-CPH Kastrup Copenhagen

17h 28m2 stops Washington, D.C. Dulles Intl Zurich

11:35 am - 2:06 pmCPH Kastrup Copenhagen-CHS Charleston

32h 31m2 stops Toronto Pearson Intl Newark

$730United Airlines

Wed, Jan 20 - Fri, Jan 22

7:47 pm - 2:05 amCLT Charlotte Douglas-IST Istanbul

23h 18m2 stops Washington, D.C. Dulles Intl Munich Franz Josef Strauss

1:55 pm - 4:20 pmIST Istanbul-CLT Charlotte Douglas

33h 25m2 stops Frankfurt am Main Toronto Pearson Intl

$734Multiple Airlines

Tue, Apr 20 - Wed, Apr 28

3:30 pm - 2:05 pmCLT Charlotte Douglas-CPH Kastrup Copenhagen

16h 35m2 stops Chicago O'Hare Intl Zurich

7:55 pm - 9:23 pmCPH Kastrup Copenhagen-CLT Charlotte Douglas

31h 28m2 stops Zurich Chicago O'Hare Intl

$735SWISS

Mon, Apr 12 - Mon, Apr 26

11:27 am - 6:25 pmMYR Myrtle Beach Intl-CPH Kastrup Copenhagen

24h 58m2 stops Newark Frankfurt am Main

11:35 am - 5:48 pmCPH Kastrup Copenhagen-MYR Myrtle Beach Intl

36h 13m2 stops Toronto Pearson Intl Newark

$737United Airlines

Wed, Jan 20 - Fri, Jan 22

12:50 pm - 4:40 pmCHS Charleston-HND Tokyo Haneda

37h 50m2 stops Chicago O'Hare Intl Toronto Pearson Intl

6:50 pm - 7:08 pmHND Tokyo Haneda-CHS Charleston

38h 18m2 stops Toronto Pearson Intl Washington, D.C. Dulles Intl

$763Air Canada

Wed, Jan 6 - Fri, Jan 29

Cheapest domestic flights from Florence, South Carolina

Enter your travel dates to find the best prices.

3:38 pm - 8:20 pmFLO Florence-BNA Nashville Intl

5h 42m1 stop Charlotte Douglas

5:03 pm - 11:57 pmBNA Nashville Intl-FLO Florence

5h 54m1 stop Charlotte Douglas

$387American Airlines

Sat, Dec 5 - Sat, Dec 19

3:37 pm - 10:29 pmFLO Florence-JFK New York John F Kennedy Intl

6h 52m1 stop Charlotte Douglas

7:59 am - 2:09 pmJFK New York John F Kennedy Intl-FLO Florence

6h 10m1 stop Charlotte Douglas

$392American Airlines

Wed, Nov 18 - Mon, Nov 23

2:35 pm - 6:29 pmFLO Florence-LGA New York LaGuardia

3h 54m1 stop Charlotte Douglas

11:29 am - 3:34 pmLGA New York LaGuardia-FLO Florence

4h 05m1 stop Charlotte Douglas

$392American Airlines

Mon, Dec 21 - Tue, Jan 19

5:05 am - 8:30 amFLO Florence-BNA Nashville Intl

4h 25m1 stop Charlotte Douglas

7:09 pm - 11:57 pmBNA Nashville Intl-FLO Florence

3h 48m1 stop Charlotte Douglas

$402American Airlines

Sun, Dec 6 - Sat, Dec 19

5:05 am - 8:30 amFLO Florence-BNA Nashville Intl

4h 25m1 stop Charlotte Douglas

5:59 pm - 11:58 pmBNA Nashville Intl-FLO Florence

4h 59m1 stop Charlotte Douglas

$417American Airlines

Thu, Dec 10 - Sun, Dec 13

3:37 pm - 10:29 pmFLO Florence-JFK New York John F Kennedy Intl

6h 52m1 stop Charlotte Douglas

7:59 am - 2:09 pmJFK New York John F Kennedy Intl-FLO Florence

6h 10m1 stop Charlotte Douglas

$424American Airlines

Wed, Nov 18 - Mon, Nov 23

5:09 am - 9:02 amFLO Florence-LGA New York LaGuardia

3h 53m1 stop Charlotte Douglas

6:00 am - 12:50 pmLGA New York LaGuardia-FLO Florence

6h 50m1 stop Charlotte Douglas

$424American Airlines

Tue, Nov 24 - Thu, Nov 26

2:35 pm - 5:45 pmFLO Florence-ORD Chicago O'Hare Intl

4h 10m1 stop Charlotte Douglas

12:05 pm - 7:12 pmORD Chicago O'Hare Intl-FLO Florence

6h 07m1 stop Charlotte Douglas

$426American Airlines

Wed, Dec 23 - Fri, Jan 1

3:37 pm - 8:33 pmFLO Florence-BNA Nashville Intl

5h 56m1 stop Charlotte Douglas

4:18 pm - 11:54 pmBNA Nashville Intl-FLO Florence

6h 36m1 stop Charlotte Douglas

$427American Airlines

Wed, Nov 18 - Wed, Nov 25

2:42 pm - 8:09 pmFLO Florence-ORD Chicago O'Hare Intl

6h 27m1 stop Charlotte Douglas

9:00 am - 3:12 pmORD Chicago O'Hare Intl-FLO Florence

5h 12m1 stop Charlotte Douglas

$441American Airlines

Fri, Dec 4 - Mon, Dec 7

Flights from Florence, South Carolina - Travel Insights & Trends

Get data-powered insights and trends into flights from Florence, South Carolina to help you craft the best travel plan.

Prices

Other information

Frequently asked questions regarding flights from Florence, South Carolina

Which airlines are currently offering the cheapest flights from Florence, South Carolina?

Our data suggests that currently, the cheapest flights from Florence, South Carolina are being offered by American Airlines. For example, American Airlines flights from Florence, South Carolina to Houston George Bush Intcntl Airport start at $308.

What is the cheapest flight available from Florence, South Carolina?

Currently, the cheapest flight from Florence, South Carolina found by our users is for $273 to Charlotte. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $506 to travel from Florence, South Carolina to Charlotte.

Which destinations have the most frequent flights from Florence, South Carolina?

Charlotte is currently the destination served most frequently from Florence, South Carolina, with 2 flights per day on average.

Which airlines can you fly with from Florence, South Carolina?

Airlines including American Airlines frequently fly from Florence, South Carolina. You can view other airlines by performing a quick search in the form above.

When did momondo last update prices for flights from Florence Airport?

Prices for flights from Florence Airport were last updated today.

How many operators does momondo search for flights from Florence Airport?

The number of operators available for flights from Florence Airport is 1 as of October 2026.

How old do you have to be to fly from Florence Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport.

What documentation or ID do you need to fly to Florence Airport?

The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.