Cheap flights from Florence, South Carolina from $229

Our data suggests that currently, the cheapest flights from Florence, South Carolina are being offered by American Airlines. For example, American Airlines flights from Florence, South Carolina to Chicago O'Hare Intl Airport start at $176.

Currently, the cheapest flight from Florence, South Carolina found by our users is for $277 to Charlotte. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $467 to travel from Florence, South Carolina to Charlotte.

Charlotte is currently the destination served most frequently from Florence, South Carolina, with 3 flights per day on average.

Airlines including American Airlines frequently fly from Florence, South Carolina. You can view other airlines by performing a quick search in the form above.

Prices for flights from Florence Airport were last updated today.

The number of operators available for flights from Florence Airport is 1 as of December 2025.

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport.

The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.