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Cheap flights from St. Louis to Panama from $395

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 6/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
1 stop
United Airlines Logo
7:55 am - 10:30 pm
PTY
-
STL
14h 35m
1 stop
$505United Airlines
Mon, May 4 - Mon, May 11
United Airlines Logo
7:09 pm - 2:14 pm
STL
-
PTY
19h 05m
2 stops
United Airlines Logo
3:30 pm - 9:30 am
PTY
-
STL
18h 00m
1 stop
$509United Airlines
Mon, May 4 - Thu, May 14
Delta Logo
4:41 pm - 1:02 pm
STL
-
PTY
20h 21m
1 stop
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
$513Delta
Sun, May 3 - Tue, May 19
United Airlines Logo
8:35 am - 4:12 pm
STL
-
PTY
7h 37m
1 stop
United Airlines Logo
3:20 pm - 6:38 pm
PTY
-
STL
27h 18m
1 stop
$514United Airlines
Thu, Jul 9 - Thu, Sep 24
United Airlines Logo
6:00 am - 7:31 pm
STL
-
PTY
13h 31m
2 stops
United Airlines Logo
3:30 pm - 5:42 pm
PTY
-
STL
26h 12m
1 stop
$518United Airlines
Wed, Jun 3 - Mon, Jun 8
United Airlines Logo
6:00 am - 4:12 pm
STL
-
PTY
10h 12m
1 stop
United Airlines Logo
7:55 am - 10:30 pm
PTY
-
STL
14h 35m
1 stop
$522United Airlines
Fri, May 1 - Tue, May 5
United Airlines Logo
7:45 am - 4:04 am
STL
-
PTY
20h 19m
2 stops
United Airlines Logo
3:30 pm - 12:47 pm
PTY
-
STL
21h 17m
2 stops
$526United Airlines
Fri, May 1 - Tue, May 5
Delta Logo
7:25 am - 1:02 pm
STL
-
PTY
29h 37m
1 stop
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
$530Delta
Sun, May 3 - Sat, May 16
United Airlines Logo
6:14 am - 6:37 pm
STL
-
PTY
12h 23m
1 stop
United Airlines Logo
3:30 pm - 2:08 pm
PTY
-
STL
22h 38m
1 stop
$531United Airlines
Sun, Aug 2 - Mon, Aug 10
United Airlines Logo
8:15 pm - 4:12 pm
STL
-
PTY
19h 57m
2 stops
United Airlines Logo
3:30 pm - 5:42 pm
PTY
-
STL
26h 12m
1 stop
$535United Airlines
Thu, Jun 4 - Mon, Jun 8

Delta flights from St. Louis to Panama

Our best Delta deals on St. Louis to Panama flight tickets
Delta
May 3
STL4:41 pmLambert-St Louis
20h 21m
1 stop
PTY1:02 pmPanama City Tocumen Intl
May 19
PTY2:15 pmPanama City Tocumen Intl
9h 44m
1 stop
STL11:59 pmLambert-St Louis
$513
Delta
May 3
STL7:25 amLambert-St Louis
29h 37m
1 stop
PTY1:02 pmPanama City Tocumen Intl
May 16
PTY2:15 pmPanama City Tocumen Intl
9h 44m
1 stop
STL11:59 pmLambert-St Louis
$530
Delta
May 20
STL6:00 amLambert-St Louis
6h 50m
1 stop
PTY12:50 pmPanama City Tocumen Intl
May 26
PTY2:15 pmPanama City Tocumen Intl
9h 44m
1 stop
STL11:59 pmLambert-St Louis
$551

Copa Airlines flights from St. Louis to Panama

Our best Copa Airlines deals on St. Louis to Panama flight tickets
Copa Airlines
May 23
STL6:00 amLambert-St Louis
13h 31m
1 stop
PTY7:31 pmPanama City Tocumen Intl
May 30
PTY10:55 pmPanama City Tocumen Intl
24h 40m
1 stop
STL11:35 pmLambert-St Louis
$560
Copa Airlines
May 30
STL6:00 amLambert-St Louis
13h 31m
1 stop
PTY7:31 pmPanama City Tocumen Intl
Jun 6
PTY3:30 pmPanama City Tocumen Intl
18h 37m
1 stop
STL10:07 amLambert-St Louis
$589
Copa Airlines
Jun 25
STL6:01 amLambert-St Louis
22h 03m
1 stop
PTY4:04 amPanama City Tocumen Intl
Sep 25
PTY10:00 amPanama City Tocumen Intl
12h 06m
1 stop
STL10:06 pmLambert-St Louis
$625

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 5/4

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 5/11

7:55 am-10:30 pm

1 stop14h 35m

$505

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 5/4

7:09 pm-2:14 pm

2 stops19h 05m

Panama City Tocumen Intl

Thu 5/14

3:30 pm-9:30 am

1 stop18h 00m

$509

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 5/3

4:41 pm-1:02 pm

1 stop20h 21m

Panama City Tocumen Intl

Tue 5/19

2:15 pm-11:59 pm

1 stop9h 44m

$513

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/9

8:35 am-4:12 pm

1 stop7h 37m

Panama City Tocumen Intl

Thu 9/24

3:20 pm-6:38 pm

1 stop27h 18m

$514

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 6/3

6:00 am-7:31 pm

2 stops13h 31m

Panama City Tocumen Intl

Mon 6/8

3:30 pm-5:42 pm

1 stop26h 12m

$518
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 5/1

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 5/5

7:55 am-10:30 pm

1 stop14h 35m

$522

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 5/1

7:45 am-4:04 am

2 stops20h 19m

Panama City Tocumen Intl

Tue 5/5

3:30 pm-12:47 pm

2 stops21h 17m

$526

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 5/3

7:25 am-1:02 pm

1 stop29h 37m

Panama City Tocumen Intl

Sat 5/16

2:15 pm-11:59 pm

1 stop9h 44m

$530

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/2

6:14 am-6:37 pm

1 stop12h 23m

Panama City Tocumen Intl

Mon 8/10

3:30 pm-2:08 pm

1 stop22h 38m

$531

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 6/4

8:15 pm-4:12 pm

2 stops19h 57m

Panama City Tocumen Intl

Mon 6/8

3:30 pm-5:42 pm

1 stop26h 12m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from St. Louis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $459. If you don’t want to visit Panama in April, then you should wait until May to fly from St. Louis, when ticket prices are also cheap, with an average price of $510.

Can stopping save me money on St. Louis to Panama flights?

You could potentially save up to 17% on your flight if you consider stops on a St. Louis to Panama flight.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Fastest flight time

7h 37m

Direct flights

None
The fastest flight from St. Louis to Panama takes 7h 37m
There are no direct flights from St. Louis to Panama. There are no popular flight routes from St. Louis to Panama.
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

    Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
8,364 reviews
Search Delta flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,525 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,543 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

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