Cheap flights from St. Louis to Panama from $271
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 3/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Fly from
Fly to
Route
Depart
Return
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Tue 3/2
6:15 am-7:38 pm
1 stop12h 23m
Panama City Tocumen Intl
Tue 3/9
9:30 am-7:40 pm
1 stop11h 10m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Tue 3/2
5:00 am-8:02 pm
2 stops14h 02m
Panama City Tocumen Intl
Tue 3/9
4:41 pm-9:42 am
1 stop18h 01m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Tue 3/2
6:00 am-7:38 pm
2 stops12h 38m
Panama City Tocumen Intl
Tue 3/9
8:55 am-11:19 pm
2 stops15h 24m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Thu 2/4
6:00 pm-3:55 pm
2 stops20h 55m
Panama City Tocumen Intl
Mon 2/15
4:31 pm-10:21 am
2 stops18h 50m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Thu 2/4
6:08 pm-3:55 pm
1 stop20h 47m
Panama City Tocumen Intl
Mon 2/15
4:31 pm-10:21 am
2 stops18h 50m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Fri 10/23
5:00 am-1:02 pm
1 stop8h 02m
Panama City Tocumen Intl
Tue 10/27
2:02 pm-9:59 pm
1 stop7h 57m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Wed 1/27
6:06 am-8:02 pm
1 stop12h 56m
Panama City Tocumen Intl
Tue 2/2
8:55 am-10:34 pm
1 stop14h 39m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Wed 1/27
6:06 am-8:02 pm
1 stop12h 56m
Panama City Tocumen Intl
Tue 2/2
8:55 am-10:34 pm
1 stop14h 39m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Wed 11/25
3:04 pm-1:20 am
3 stops33h 16m
Panama City Tocumen Intl
Sun 11/29
4:10 pm-11:59 pm
2 stops32h 49m
St. LouisPanama City
STL Lambert-St Louis - PTY Panama City Tocumen Intl
STLPTY
Lambert-St Louis
Mon 11/9
6:34 pm-2:10 am
3 stops30h 36m
Panama City Tocumen Intl
Thu 11/12
5:30 am-12:33 pm
3 stops32h 03m
See travel insights to Panama from
How to get the cheapest flight ticket from St. Louis to Panama
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest airline that flies from Lambert-St Louis to Panama?
United Airlines and American Airlines are the most popular carriers operating from Lambert-St Louis to Panama
What airlines fly to Panama?
United Airlines, Delta and American Airlines are the top three most popular airlines that fly to Panama from St. Louis according to our data. United Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.
Cheap St. Louis to Panama flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama
Frequently asked questions about flying from St. Louis to Panama
When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?
Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.
How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?
The number of operators available for flights from Lambert-St Louis Airport to Panama is 4 as of October 2026.
How old do you have to be to fly from Lambert-St Louis Airport to Panama?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
Best airlines flying from St. Louis to Panama
Compare and see reviews for airlines that fly from St. Louis to Panama with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $393 | Free Cancellation | Rating 7.0 12,129 reviews | |||
| PriceFrom $393 | Free Cancellation | Rating 7.4 10,301 reviews | |||
| PriceFrom $446 | Free Cancellation | Rating 7.6 1,546 reviews | |||
| PriceFrom $478 | Free Cancellation | Rating 7.8 8,633 reviews |
Why use momondo?
Why should I use momondo to find a flight deal from St. Louis to Panama?
momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.
Can I find flights from St. Louis to Panama with flexible booking policies on momondo?
Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.
How can momondo help me find flights from St. Louis to Panama?
Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.
I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?
If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.