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Cheap flights from St. Louis to Panama from $234

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 6/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 am - 12:24 pm
STL
-
PTY
7h 24m
1 stop
American Airlines Logo
1:24 pm - 10:40 pm
PTY
-
STL
9h 16m
1 stop
$535American Airlines
Thu, Aug 13 - Tue, Aug 18
United Airlines Logo
7:05 pm - 4:12 pm
STL
-
PTY
21h 07m
2 stops
United Airlines Logo
3:30 pm - 12:11 pm
PTY
-
STL
20h 41m
2 stops
$539United Airlines
Tue, Jul 21 - Wed, Jul 29
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
United Airlines Logo
9:45 am - 11:44 pm
PTY
-
STL
13h 59m
1 stop
$544United Airlines
Mon, Jul 27 - Mon, Aug 3
American Airlines Logo
11:35 am - 12:24 pm
STL
-
PTY
24h 49m
1 stop
American Airlines Logo
1:24 pm - 10:40 pm
PTY
-
STL
9h 16m
1 stop
$547American Airlines
Wed, Aug 5 - Fri, Sep 4
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
United Airlines Logo
3:30 pm - 8:34 am
PTY
-
STL
17h 04m
2 stops
$549United Airlines
Thu, Jul 9 - Mon, Jul 13
United Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
United Airlines Logo
9:45 am - 11:36 pm
PTY
-
STL
13h 51m
1 stop
$552United Airlines
Fri, Jul 31 - Tue, Aug 4
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
United Airlines Logo
10:55 pm - 11:36 pm
PTY
-
STL
24h 41m
1 stop
$554United Airlines
Thu, Jul 9 - Mon, Jul 13
American Airlines Logo
5:00 am - 12:24 pm
STL
-
PTY
7h 24m
1 stop
American Airlines Logo
1:24 pm - 10:40 pm
PTY
-
STL
9h 16m
1 stop
$555American Airlines
Wed, Aug 12 - Wed, Aug 19
United Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
United Airlines Logo
3:30 pm - 12:11 pm
PTY
-
STL
20h 41m
2 stops
$556United Airlines
Fri, Jul 31 - Tue, Aug 4
United Airlines Logo
7:05 pm - 4:12 pm
STL
-
PTY
21h 07m
2 stops
United Airlines Logo
7:55 am - 5:42 pm
PTY
-
STL
9h 47m
1 stop
$559United Airlines
Mon, Jul 13 - Thu, Jul 16

American Airlines flights from St. Louis to Panama

Our best American Airlines deals on St. Louis to Panama flight tickets
American Airlines
Aug 13
STL5:00 amLambert-St Louis
7h 24m
1 stop
PTY12:24 pmPanama City Tocumen Intl
Aug 18
PTY1:24 pmPanama City Tocumen Intl
9h 16m
1 stop
STL10:40 pmLambert-St Louis
$535
American Airlines
Aug 5
STL11:35 amLambert-St Louis
24h 49m
1 stop
PTY12:24 pmPanama City Tocumen Intl
Sep 4
PTY1:24 pmPanama City Tocumen Intl
9h 16m
1 stop
STL10:40 pmLambert-St Louis
$547
American Airlines
Aug 12
STL5:00 amLambert-St Louis
7h 24m
1 stop
PTY12:24 pmPanama City Tocumen Intl
Aug 19
PTY1:24 pmPanama City Tocumen Intl
9h 16m
1 stop
STL10:40 pmLambert-St Louis
$555

United Airlines flights from St. Louis to Panama

Our best United Airlines deals on St. Louis to Panama flight tickets
United Airlines
Jul 21
STL7:05 pmLambert-St Louis
21h 07m
2 stops
PTY4:12 pmPanama City Tocumen Intl
Jul 29
PTY3:30 pmPanama City Tocumen Intl
20h 41m
2 stops
STL12:11 pmLambert-St Louis
$539
United Airlines
Jul 27
STL6:01 amLambert-St Louis
22h 03m
1 stop
PTY4:04 amPanama City Tocumen Intl
Aug 3
PTY9:45 amPanama City Tocumen Intl
13h 59m
1 stop
STL11:44 pmLambert-St Louis
$544
United Airlines
Jul 9
STL6:01 amLambert-St Louis
22h 03m
1 stop
PTY4:04 amPanama City Tocumen Intl
Jul 13
PTY3:30 pmPanama City Tocumen Intl
17h 04m
2 stops
STL8:34 amLambert-St Louis
$549

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 22, 2026.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 8/13

5:00 am-12:24 pm

1 stop7h 24m

Panama City Tocumen Intl

Tue 8/18

1:24 pm-10:40 pm

1 stop9h 16m

$535

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 7/21

7:05 pm-4:12 pm

2 stops21h 07m

Panama City Tocumen Intl

Wed 7/29

3:30 pm-12:11 pm

2 stops20h 41m

$539

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/27

6:01 am-4:04 am

1 stop22h 03m

Panama City Tocumen Intl

Mon 8/3

9:45 am-11:44 pm

1 stop13h 59m

$544

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 8/5

11:35 am-12:24 pm

1 stop24h 49m

Panama City Tocumen Intl

Fri 9/4

1:24 pm-10:40 pm

1 stop9h 16m

$547

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/9

6:01 am-4:04 am

1 stop22h 03m

Panama City Tocumen Intl

Mon 7/13

3:30 pm-8:34 am

2 stops17h 04m

$549

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/31

11:10 am-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Tue 8/4

9:45 am-11:36 pm

1 stop13h 51m

$552

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/9

6:01 am-4:04 am

1 stop22h 03m

Panama City Tocumen Intl

Mon 7/13

10:55 pm-11:36 pm

1 stop24h 41m

$554

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 8/12

5:00 am-12:24 pm

1 stop7h 24m

Panama City Tocumen Intl

Wed 8/19

1:24 pm-10:40 pm

1 stop9h 16m

$555

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/31

11:10 am-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Tue 8/4

3:30 pm-12:11 pm

2 stops20h 41m

$556

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/13

7:05 pm-4:12 pm

2 stops21h 07m

Panama City Tocumen Intl

Thu 7/16

7:55 am-5:42 pm

1 stop9h 47m

$559

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from St. Louis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of February is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $174. If you don’t want to visit Panama in February, then you should wait until January to fly from St. Louis, when ticket prices are also cheap, with an average price of $362.

How far in advance should I book a flight from St. Louis to Panama?

You are more likely to see cheaper flights to Panama from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $593 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from St. Louis for as low as $394 on momondo.

Can stopping save me money on St. Louis to Panama flights?

You could potentially save up to 23% on your flight if you consider stops on a St. Louis to Panama flight.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Fastest flight time

6h 55m

Direct flights

None
The fastest flight from St. Louis to Panama takes 6h 55m
There are no direct flights from St. Louis to Panama. There are no popular flight routes from St. Louis to Panama.
Search flight deals

Frequently asked questions about flying from St. Louis to Panama

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

    Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,751 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,644 reviews
Search American Airlines flights
DeltaPriceFrom $452Free CancellationRating
7.9
8,449 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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