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Cheap flights from St. Louis to Panama from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Panama

Cheap round-trip flights

Delta Logo
6:00 am - 12:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
2:21 pm - 11:41 pmPTY-STL
9h 20m1 stop
$386Delta
Find Deal
Mon, Oct 13 - Thu, Oct 23
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
10:00 am - 6:57 pmPTY-STL
8h 57m1 stop
$393United Airlines
Find Deal
Tue, Oct 14 - Wed, Oct 22
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
3:30 pm - 10:49 amPTY-STL
19h 19m2 stops
$398United Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
American Airlines Logo
3:03 pm - 2:03 pmSTL-PTY
23h 00m2 stops
American Airlines Logo
3:15 pm - 9:35 amPTY-STL
18h 20m2 stops
$399American Airlines
Find Deal
Tue, Oct 14 - Thu, Oct 23
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
3:41 pm - 6:47 pmPTY-STL
27h 06m1 stop
$401United Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
Delta Logo
6:00 am - 12:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
2:21 pm - 11:41 pmPTY-STL
9h 20m1 stop
$403Delta
Find Deal
Mon, Oct 13 - Fri, Oct 24
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
10:00 am - 10:00 pmPTY-STL
12h 00m1 stop
$410United Airlines
Find Deal
Fri, Oct 17 - Tue, Oct 21
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
3:30 pm - 10:49 amPTY-STL
19h 19m2 stops
$415United Airlines
Find Deal
Fri, Oct 17 - Thu, Oct 23
American Airlines Logo
6:08 pm - 2:03 pmSTL-PTY
19h 55m1 stop
American Airlines Logo
3:15 pm - 9:28 amPTY-STL
18h 13m2 stops
$473American Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
American Airlines Logo
3:03 pm - 2:03 pmSTL-PTY
23h 00m2 stops
American Airlines Logo
3:15 pm - 12:05 pmPTY-STL
20h 50m2 stops
$480American Airlines
Find Deal
Wed, Oct 15 - Thu, Oct 23

Delta flights from St. Louis to Panama

Our best Delta deals on St. Louis to Panama flight tickets
Delta
Oct 13
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 23
PTY2:21 pmPanama City Tocumen Intl
9h 20m
1 stop
STL11:41 pmLambert-St Louis
$386
Find similar
Delta
Oct 13
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 24
PTY2:21 pmPanama City Tocumen Intl
9h 20m
1 stop
STL11:41 pmLambert-St Louis
$403
Find similar
Delta
Oct 13
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 25
PTY2:21 pmPanama City Tocumen Intl
17h 44m
1 stop
STL8:05 amLambert-St Louis
$462
Find similar

United Airlines flights from St. Louis to Panama

Our best United Airlines deals on St. Louis to Panama flight tickets
United Airlines
Oct 14
STL6:15 amLambert-St Louis
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Oct 22
PTY10:00 amPanama City Tocumen Intl
8h 57m
1 stop
STL6:57 pmLambert-St Louis
$393
Find similar
United Airlines
Oct 13
STL6:15 amLambert-St Louis
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 20
PTY3:30 pmPanama City Tocumen Intl
19h 19m
2 stops
STL10:49 amLambert-St Louis
$398
Find similar
United Airlines
Oct 23
STL6:15 amLambert-St Louis
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 27
PTY3:41 pmPanama City Tocumen Intl
27h 06m
1 stop
STL6:47 pmLambert-St Louis
$401
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-11:41 pm

1 stop9h 20m

$386

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 10/22

10:00 am-6:57 pm

1 stop8h 57m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

3:03 pm-2:03 pm

2 stops23h 00m

Panama City Tocumen Intl

Thu 10/23

3:15 pm-9:35 am

2 stops18h 20m

$399

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/23

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/27

3:41 pm-6:47 pm

1 stop27h 06m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Fri 10/24

2:21 pm-11:41 pm

1 stop9h 20m

$403

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 10/17

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$410

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 10/17

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 10/23

3:30 pm-10:49 am

2 stops19h 19m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/23

6:08 pm-2:03 pm

1 stop19h 55m

Panama City Tocumen Intl

Mon 10/27

3:15 pm-9:28 am

2 stops18h 13m

$473

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/15

3:03 pm-2:03 pm

2 stops23h 00m

Panama City Tocumen Intl

Thu 10/23

3:15 pm-12:05 pm

2 stops20h 50m

$480

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from St. Louis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $441. If you don’t want to visit Panama in April, then you should wait until May to fly from St. Louis, when ticket prices are also cheap, with an average price of $506.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from St. Louis. The lowest ticket price found for a Tuesday departure recently was $509. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Panama for around $607.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from St. Louis to Panama when you can find flight prices for as low as $512. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $691 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $550 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from St. Louis for as low as $456 on momondo.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Direct flights

None
There are no direct flights from St. Louis to Panama. There are no popular flight routes from St. Louis to Panama.
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

    Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
7,957 reviews
Search Delta flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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