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Cheap flights from St. Louis to Panama from $272

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 11/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 7:38 pmSTL-PTY
12h 38m1 stop
United Airlines Logo
7:55 am - 10:13 pmPTY-STL
14h 18m1 stop
$394United Airlines
Find Deal
Wed, Feb 25 - Wed, Mar 11
United Airlines Logo
6:30 am - 8:02 pmSTL-PTY
12h 32m2 stops
United Airlines Logo
3:41 pm - 10:21 amPTY-STL
18h 40m2 stops
$398United Airlines
Find Deal
Thu, Feb 26 - Thu, Mar 12
Delta Logo
6:48 pm - 2:02 pmSTL-PTY
18h 14m1 stop
Delta Logo
2:20 pm - 11:40 pmPTY-STL
9h 20m1 stop
$401Delta
Find Deal
Sun, Feb 22 - Wed, Mar 11
American Airlines Logo
6:02 pm - 1:27 pmSTL-PTY
18h 25m1 stop
American Airlines Logo
4:50 pm - 9:08 amPTY-STL
17h 18m1 stop
$403American Airlines
Find Deal
Mon, Jan 19 - Fri, Jan 23
Delta Logo
6:48 pm - 2:02 pmSTL-PTY
18h 14m1 stop
Delta Logo
2:20 pm - 9:04 amPTY-STL
18h 44m1 stop
$408Delta
Find Deal
Sun, Feb 22 - Thu, Mar 12
United Airlines Logo
6:00 am - 2:45 pmSTL-PTY
7h 45m1 stop
United Airlines Logo
7:55 am - 10:13 pmPTY-STL
14h 18m1 stop
$411United Airlines
Find Deal
Sat, Feb 28 - Mon, Mar 9
American Airlines Logo
4:32 pm - 12:15 pmSTL-PTY
19h 43m2 stops
American Airlines Logo
1:55 pm - 9:35 pmPTY-STL
7h 40m1 stop
$415American Airlines
Find Deal
Fri, Apr 10 - Fri, Apr 17
United Airlines Logo
10:07 am - 5:07 pmSTL-PTY
30h 00m1 stop
United Airlines Logo
4:41 pm - 9:23 amPTY-STL
17h 42m1 stop
$419United Airlines
Find Deal
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
11:19 am - 1:40 pmSTL-PTY
25h 21m1 stop
American Airlines Logo
2:52 pm - 11:07 amPTY-STL
21h 15m2 stops
$426American Airlines
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Fri, Feb 20 - Wed, Feb 25
United Airlines Logo
6:00 am - 5:07 pmSTL-PTY
10h 07m1 stop
United Airlines Logo
11:35 am - 10:13 pmPTY-STL
10h 38m1 stop
$428United Airlines
Find Deal
Sun, Feb 22 - Fri, Mar 13

United Airlines flights from St. Louis to Panama

Our best United Airlines deals on St. Louis to Panama flight tickets
United Airlines
Feb 25
STL6:00 amLambert-St Louis
12h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Mar 11
PTY7:55 amPanama City Tocumen Intl
14h 18m
1 stop
STL10:13 pmLambert-St Louis
$394
Find similar
United Airlines
Feb 26
STL6:30 amLambert-St Louis
12h 32m
2 stops
PTY8:02 pmPanama City Tocumen Intl
Mar 12
PTY3:41 pmPanama City Tocumen Intl
18h 40m
2 stops
STL10:21 amLambert-St Louis
$398
Find similar
United Airlines
Feb 28
STL6:00 amLambert-St Louis
7h 45m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Mar 9
PTY7:55 amPanama City Tocumen Intl
14h 18m
1 stop
STL10:13 pmLambert-St Louis
$411
Find similar

Delta flights from St. Louis to Panama

Our best Delta deals on St. Louis to Panama flight tickets
Delta
Feb 22
STL6:48 pmLambert-St Louis
18h 14m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Mar 11
PTY2:20 pmPanama City Tocumen Intl
9h 20m
1 stop
STL11:40 pmLambert-St Louis
$401
Find similar
Delta
Feb 22
STL6:48 pmLambert-St Louis
18h 14m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Mar 12
PTY2:20 pmPanama City Tocumen Intl
18h 44m
1 stop
STL9:04 amLambert-St Louis
$408
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/25

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 3/11

7:55 am-10:13 pm

1 stop14h 18m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 2/26

6:30 am-8:02 pm

2 stops12h 32m

Panama City Tocumen Intl

Thu 3/12

3:41 pm-10:21 am

2 stops18h 40m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/22

6:48 pm-2:02 pm

1 stop18h 14m

Panama City Tocumen Intl

Wed 3/11

2:20 pm-11:40 pm

1 stop9h 20m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 1/19

6:02 pm-1:27 pm

1 stop18h 25m

Panama City Tocumen Intl

Fri 1/23

4:50 pm-9:08 am

1 stop17h 18m

$403

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/22

6:48 pm-2:02 pm

1 stop18h 14m

Panama City Tocumen Intl

Thu 3/12

2:20 pm-9:04 am

1 stop18h 44m

$408

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 2/28

6:00 am-2:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Mon 3/9

7:55 am-10:13 pm

1 stop14h 18m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

4:32 pm-12:15 pm

2 stops19h 43m

Panama City Tocumen Intl

Fri 4/17

1:55 pm-9:35 pm

1 stop7h 40m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/10

10:07 am-5:07 pm

1 stop30h 00m

Panama City Tocumen Intl

Sat 2/14

4:41 pm-9:23 am

1 stop17h 42m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 2/20

11:19 am-1:40 pm

1 stop25h 21m

Panama City Tocumen Intl

Wed 2/25

2:52 pm-11:07 am

2 stops21h 15m

$426

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/22

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Fri 3/13

11:35 am-10:13 pm

1 stop10h 38m

$428

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from St. Louis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $441. If you don’t want to visit Panama in April, then you should wait until May to fly from St. Louis, when ticket prices are also cheap, with an average price of $504.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from St. Louis. The lowest ticket price found for a Tuesday departure recently was $509. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Panama for around $607.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from St. Louis to Panama when you can find flight prices for as low as $512. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $691 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $548 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from St. Louis for as low as $410 on momondo.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Direct flights

None
There are no direct flights from St. Louis to Panama. There are no popular flight routes from St. Louis to Panama.
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

    Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $394Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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