What day of the week experiences the fewest flight delays on this route?

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Tuesday has historically seen more delays on average compared to the rest of the week.

What is the cheapest airline that flies from Lambert-St Louis to Panama?

American Airlines and United Airlines are the most popular carriers operating from Lambert-St Louis to Panama

What airlines fly to Panama?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Panama from St. Louis according to our data. United Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

What is the most punctual flight time for St. Louis to Panama flights?

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

How often are flights from St. Louis to Panama delayed?

Historically, on average around 0% of flights between St. Louis and Panama have experienced a delay on any given week. The average delay length over the past 12 months has been 0 minutes.

When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.

How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

The number of operators available for flights from Lambert-St Louis Airport to Panama is 3 as of December 2025.

How old do you have to be to fly from Lambert-St Louis Airport to Panama?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$170 Cheap Flights from St. Louis to Panama in 2025/26

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Cheap round-trip flights

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6:00 am - 12:55 pm

STL

PTY

6h 55m1 stop

2:20 pm - 11:33 pm

PTY

STL

9h 13m1 stop

$394Delta

Wed, Apr 29 - Wed, May 6

7:03 pm - 12:15 pm

STL

PTY

17h 12m2 stops

1:55 pm - 9:40 am

PTY

STL

19h 45m2 stops

$398American Airlines

Wed, Apr 29 - Wed, May 6

10:10 am - 6:37 pm

STL

PTY

8h 27m1 stop

7:55 am - 10:28 pm

PTY

STL

14h 33m1 stop

$411United Airlines

Tue, Apr 21 - Sat, Apr 25

6:30 am - 7:31 pm

STL

PTY

13h 01m2 stops

10:00 am - 10:28 pm

PTY

STL

12h 28m1 stop

$415United Airlines

Tue, Apr 21 - Sat, Apr 25

6:00 am - 5:07 pm

STL

PTY

10h 07m1 stop

4:41 pm - 10:14 pm

PTY

STL

30h 33m1 stop

$419United Airlines

Sat, Feb 21 - Mon, Mar 2

6:45 pm - 5:07 pm

STL

PTY

21h 22m2 stops

4:41 pm - 10:14 pm

PTY

STL

30h 33m1 stop

$423United Airlines

Fri, Feb 20 - Mon, Mar 2

6:00 am - 2:14 pm

STL

PTY

8h 14m1 stop

7:55 am - 10:27 pm

PTY

STL

14h 32m1 stop

$428United Airlines

Fri, Apr 10 - Fri, Apr 17

6:35 pm - 2:14 pm

STL

PTY

19h 39m2 stops

10:00 am - 10:27 pm

PTY

STL

12h 27m1 stop

$432United Airlines

Fri, Apr 10 - Fri, Apr 17

6:56 pm - 3:15 pm

STL

PTY

19h 19m2 stops

4:05 pm - 12:29 pm

PTY

STL

21h 24m2 stops

$437American Airlines

Sat, Feb 21 - Sun, Mar 1

6:25 am - 8:02 pm

STL

PTY

12h 37m2 stops

4:41 pm - 12:21 pm

PTY

STL

20h 40m2 stops

$443United Airlines

Tue, Feb 17 - Wed, Feb 25

Delta flights from St. Louis to Panama

Our best Delta deals on St. Louis to Panama flight tickets

Delta

Apr 29

STL6:00 amLambert-St Louis

6h 55m

1 stop

PTY12:55 pmPanama City Tocumen Intl

May 6

PTY2:20 pmPanama City Tocumen Intl

9h 13m

1 stop

STL11:33 pmLambert-St Louis

$394

Find similar

Delta

Feb 17

STL6:00 amLambert-St Louis

6h 50m

1 stop

PTY1:50 pmPanama City Tocumen Intl

Feb 25

PTY3:15 pmPanama City Tocumen Intl

9h 21m

1 stop

STL11:36 pmLambert-St Louis

$529

Find similar

Delta

Feb 20

STL6:47 pmLambert-St Louis

18h 03m

1 stop

PTY1:50 pmPanama City Tocumen Intl

Mar 3

PTY3:15 pmPanama City Tocumen Intl

9h 21m

1 stop

STL11:36 pmLambert-St Louis

$556

Find similar

American Airlines flights from St. Louis to Panama

Our best American Airlines deals on St. Louis to Panama flight tickets

American Airlines

Apr 29

STL7:03 pmLambert-St Louis

17h 12m

2 stops

PTY12:15 pmPanama City Tocumen Intl

May 6

PTY1:55 pmPanama City Tocumen Intl

19h 45m

2 stops

STL9:40 amLambert-St Louis

$398

Find similar

American Airlines

Feb 21

STL6:56 pmLambert-St Louis

19h 19m

2 stops

PTY3:15 pmPanama City Tocumen Intl

Mar 1

PTY4:05 pmPanama City Tocumen Intl

21h 24m

2 stops

STL12:29 pmLambert-St Louis

$437

Find similar

American Airlines

Mar 13

STL3:51 pmLambert-St Louis

20h 49m

2 stops

PTY12:40 pmPanama City Tocumen Intl

Mar 18

PTY1:44 pmPanama City Tocumen Intl

20h 48m

1 stop

STL10:32 amLambert-St Louis

$473

Find similar

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:33 pm

1 stop9h 13m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

7:03 pm-12:15 pm

2 stops17h 12m

Panama City Tocumen Intl

Wed 5/6

1:55 pm-9:40 am

2 stops19h 45m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/21

10:10 am-6:37 pm

1 stop8h 27m

Panama City Tocumen Intl

Sat 4/25

7:55 am-10:28 pm

1 stop14h 33m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/21

6:30 am-7:31 pm

2 stops13h 01m

Panama City Tocumen Intl

Sat 4/25

10:00 am-10:28 pm

1 stop12h 28m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 2/21

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-10:14 pm

1 stop30h 33m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 2/20

6:45 pm-5:07 pm

2 stops21h 22m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-10:14 pm

1 stop30h 33m

$423

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Fri 4/17

7:55 am-10:27 pm

1 stop14h 32m

$428

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

6:35 pm-2:14 pm

2 stops19h 39m

Panama City Tocumen Intl

Fri 4/17

10:00 am-10:27 pm

1 stop12h 27m

$432

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 2/21

6:56 pm-3:15 pm

2 stops19h 19m

Panama City Tocumen Intl

Sun 3/1

4:05 pm-12:29 pm

2 stops21h 24m

$437

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:25 am-8:02 pm

2 stops12h 37m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-12:21 pm

2 stops20h 40m

$443

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Delays

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $459. If you don’t want to visit Panama in April, then you should wait until May to fly from St. Louis, when ticket prices are also cheap, with an average price of $509.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from St. Louis. The lowest ticket price found for a Tuesday departure recently was $509. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Panama for around $607.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from St. Louis to Panama when you can find flight prices for as low as $512. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $691 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $567 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from St. Louis for as low as $437 on momondo.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Fastest flight time	7h 45m
Direct flights	None

The fastest flight from St. Louis to Panama takes 7h 45m

There are no direct flights from St. Louis to Panama. There are no popular flight routes from St. Louis to Panama.

Search flight deals

When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?
Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.
How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?
The number of operators available for flights from Lambert-St Louis Airport to Panama is 3 as of December 2025.
How old do you have to be to fly from Lambert-St Louis Airport to Panama?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $373	Free Cancellation	Rating 7.9 8,014 reviews	Search Delta flights
United Airlines	PriceFrom $393	Free Cancellation	Rating 7.4 9,102 reviews	Search United Airlines flights
American Airlines	PriceFrom $394	Free Cancellation	Rating 7.2 11,052 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

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Popular cities in Panama

Flights to Panama Cityfrom $325

Flights to Bocas del Torofrom $663

Flights to Davidfrom $459

Flights to Changuinola

Cheap flights from St. Louis to Panama from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 2/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from St. Louis to Panama

Our best Delta deals on St. Louis to Panama flight tickets

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Our best American Airlines deals on St. Louis to Panama flight tickets

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How to get the cheapest flight ticket from St. Louis to Panama

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $459. If you don’t want to visit Panama in April, then you should wait until May to fly from St. Louis, when ticket prices are also cheap, with an average price of $509.

What is the cheapest day to depart on your flight to Panama?

What is the cheapest time of day to depart on your flight to Panama?

How far in advance should I book a flight to Panama?

What is the cheapest airline that flies from Lambert-St Louis to Panama?

American Airlines and United Airlines are the most popular carriers operating from Lambert-St Louis to Panama

What airlines fly to Panama?

How often are flights from St. Louis to Panama delayed?

Historically, on average around 0% of flights between St. Louis and Panama have experienced a delay on any given week. The average delay length over the past 12 months has been 0 minutes.

What is the most punctual flight time for St. Louis to Panama flights?

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

What day of the week experiences the fewest flight delays on this route?

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Tuesday has historically seen more delays on average compared to the rest of the week.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Fastest flight time

Direct flights

When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

How old do you have to be to fly from Lambert-St Louis Airport to Panama?

What documentation or ID do you need to fly to Panama?

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

How can momondo help me find flights from St. Louis to Panama?

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo