Cheap flights from St. Louis to Panama from $197

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama departing on 3/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.

Find the cheapest flights from St. Louis to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 4:12 pm
STL
-
PTY
10h 12m
1 stop
United Airlines Logo
7:55 am - 4:01 pm
PTY
-
STL
8h 06m
1 stop
$425United Airlines
Wed, Apr 29 - Tue, May 5
United Airlines Logo
6:00 am - 2:14 pm
STL
-
PTY
8h 14m
1 stop
United Airlines Logo
3:30 pm - 8:18 am
PTY
-
STL
16h 48m
2 stops
$429United Airlines
Wed, Apr 29 - Wed, May 6
Delta Logo
6:50 pm - 1:02 pm
STL
-
PTY
18h 12m
1 stop
Delta Logo
2:20 pm - 8:18 am
PTY
-
STL
17h 58m
1 stop
$432Delta
Sun, Apr 26 - Thu, May 7
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
1 stop
United Airlines Logo
3:30 pm - 9:25 am
PTY
-
STL
17h 55m
1 stop
$433United Airlines
Tue, Apr 21 - Sat, Apr 25
United Airlines Logo
6:00 am - 2:14 pm
STL
-
PTY
8h 14m
1 stop
United Airlines Logo
7:55 am - 4:01 pm
PTY
-
STL
8h 06m
1 stop
$442United Airlines
Fri, May 1 - Wed, May 6
United Airlines Logo
6:00 am - 2:14 pm
STL
-
PTY
8h 14m
1 stop
United Airlines Logo
10:55 pm - 12:34 pm
PTY
-
STL
13h 39m
2 stops
$446United Airlines
Tue, Apr 28 - Fri, May 8
Delta Logo
6:50 pm - 1:02 pm
STL
-
PTY
18h 12m
1 stop
Delta Logo
2:20 pm - 8:09 am
PTY
-
STL
17h 49m
1 stop
$449Delta
Sun, Apr 26 - Fri, May 8
American Airlines Logo
6:54 pm - 12:46 pm
STL
-
PTY
17h 52m
2 stops
American Airlines Logo
1:49 pm - 12:48 pm
PTY
-
STL
22h 59m
2 stops
$451American Airlines
Thu, May 14 - Sun, May 17
Copa Airlines Logo
6:00 am - 4:12 pm
STL
-
PTY
10h 12m
1 stop
Copa Airlines Logo
9:45 am - 11:57 pm
PTY
-
STL
14h 12m
1 stop
$452Copa Airlines
Thu, May 14 - Sun, May 17
American Airlines Logo
6:57 pm - 2:20 pm
STL
-
PTY
19h 23m
2 stops
American Airlines Logo
1:40 pm - 10:32 am
PTY
-
STL
20h 52m
1 stop
$457American Airlines
Sat, Mar 21 - Thu, Mar 26

United Airlines flights from St. Louis to Panama

Our best United Airlines deals on St. Louis to Panama flight tickets
United Airlines
Apr 29
STL6:00 amLambert-St Louis
8h 14m
1 stop
PTY2:14 pmPanama City Tocumen Intl
May 6
PTY3:30 pmPanama City Tocumen Intl
16h 48m
2 stops
STL8:18 amLambert-St Louis
$429
United Airlines
Apr 21
STL6:00 amLambert-St Louis
12h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Apr 25
PTY3:30 pmPanama City Tocumen Intl
17h 55m
1 stop
STL9:25 amLambert-St Louis
$433
United Airlines
May 1
STL6:00 amLambert-St Louis
8h 14m
1 stop
PTY2:14 pmPanama City Tocumen Intl
May 6
PTY7:55 amPanama City Tocumen Intl
8h 06m
1 stop
STL4:01 pmLambert-St Louis
$442

American Airlines flights from St. Louis to Panama

Our best American Airlines deals on St. Louis to Panama flight tickets
American Airlines
May 14
STL6:54 pmLambert-St Louis
17h 52m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 17
PTY1:49 pmPanama City Tocumen Intl
18h 41m
2 stops
STL8:30 amLambert-St Louis
$451
American Airlines
Mar 21
STL6:57 pmLambert-St Louis
19h 23m
2 stops
PTY2:20 pmPanama City Tocumen Intl
Mar 26
PTY1:40 pmPanama City Tocumen Intl
20h 52m
1 stop
STL10:32 amLambert-St Louis
$457
American Airlines
Aug 2
STL5:46 pmLambert-St Louis
18h 24m
2 stops
PTY12:10 pmPanama City Tocumen Intl
Aug 9
PTY3:20 pmPanama City Tocumen Intl
20h 51m
2 stops
STL12:11 pmLambert-St Louis
$468

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 5/5

7:55 am-4:01 pm

1 stop8h 06m

$425

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Wed 5/6

3:30 pm-8:18 am

2 stops16h 48m

$429

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 4/26

6:50 pm-1:02 pm

1 stop18h 12m

Panama City Tocumen Intl

Thu 5/7

2:20 pm-8:18 am

1 stop17h 58m

$432

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/21

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sat 4/25

3:30 pm-9:25 am

1 stop17h 55m

$433

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 5/1

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Wed 5/6

7:55 am-4:01 pm

1 stop8h 06m

$442

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/28

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Fri 5/8

10:55 pm-12:34 pm

2 stops13h 39m

$446

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 4/26

6:50 pm-1:02 pm

1 stop18h 12m

Panama City Tocumen Intl

Fri 5/8

2:20 pm-8:09 am

1 stop17h 49m

$449

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/14

6:54 pm-12:46 pm

2 stops17h 52m

Panama City Tocumen Intl

Sun 5/17

1:49 pm-12:48 pm

2 stops22h 59m

$451

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/14

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Sun 5/17

9:45 am-11:57 pm

1 stop14h 12m

$452

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 3/21

6:57 pm-2:20 pm

2 stops19h 23m

Panama City Tocumen Intl

Thu 3/26

1:40 pm-10:32 am

1 stop20h 52m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

See travel insights to Panama from

How to get the cheapest flight ticket from St. Louis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from St. Louis, with most prices found around $435. If you don’t want to visit Panama in April, then you should wait until November to fly from St. Louis, when ticket prices are also cheap, with an average price of $510.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $572 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from St. Louis for as low as $416 on momondo.

Can stopping save me money on St. Louis to Panama flights?

You could potentially save up to 20% on your flight if you consider stops on a St. Louis to Panama flight.

Cheap St. Louis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama

Fastest flight time

10h 00m

Direct flights

None
The fastest flight from St. Louis to Panama takes 10h 00m
There are no direct flights from St. Louis to Panama. There are no popular flight routes from St. Louis to Panama.
  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama?

    Prices for flights from Lambert-St Louis Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from St. Louis to Panama

Compare and see reviews for airlines that fly from St. Louis to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $227Free CancellationRating
7.9
8,203 reviews
Search Delta flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,289 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.2
11,288 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from St. Louis.

I’m not ready to book a flight from St. Louis to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 3/16
Mon 3/23

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo