How long does it take to fly to Des Moines?

If you’re flying from a popular airport in South Carolina, such as Greenville or Columbia, and flying into Des Moines, then you can expect flight times to average 4h 25m and 4h 53m, respectively.

How many flights depart from South Carolina to Des Moines on average per week?

As of September 2025, there are 14 flights per week flying from South Carolina to Des Moines. The most common day of the week flights depart is Mon, with 14% of flights taking off on this day.

What is the cheapest airline that flies from South Carolina to Des Moines?

United Airlines, Delta, and Frontier are the most popular carriers operating from South Carolina to Des Moines

What airlines fly to Des Moines?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Des Moines from South Carolina according to our data. Delta is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from South Carolina to Des Moines Airport?

Prices for flights from South Carolina to Des Moines Airport refresh daily.

How many operators does momondo search for flights from South Carolina to Des Moines Airport?

There are 3 operators available for flights from South Carolina to Des Moines Airport as of September 2025.

How old do you have to be to fly from South Carolina to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$112 Cheap Flights from South Carolina to Des Moines in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from South Carolina to Des Moines

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

5:08 pm - 2:50 pmCHS-DSM

22h 42m1 stop

8:30 am - 8:15 pmDSM-CHS

10h 45m1 stop

$195Multiple Airlines

Find Deal

jeu., oct. 30 - lun., nov. 3

12:36 pm - 5:08 pmCLT-DSM

5h 32m1 stop

2:32 pm - 5:17 pmDSM-CLT

25h 45m1 stop

$203Multiple Airlines

Find Deal

ven., nov. 14 - dim., nov. 16

9:00 am - 3:33 pmCAE-DSM

7h 33m1 stop

3:39 pm - 10:52 pmDSM-CAE

6h 13m1 stop

$249American Airlines

Find Deal

sam., nov. 8 - sam., nov. 15

2:29 pm - 11:44 pmCAE-DSM

10h 15m2 stops

3:15 pm - 9:30 pmDSM-CAE

5h 15m1 stop

$254United Airlines

Find Deal

sam., nov. 8 - sam., nov. 15

2:29 pm - 11:44 pmCAE-DSM

10h 15m2 stops

9:01 am - 9:30 pmDSM-CAE

11h 29m2 stops

$259United Airlines

Find Deal

sam., nov. 8 - sam., nov. 15

3:52 pm - 10:59 pmSAV-DSM

8h 07m1 stop

4:03 pm - 9:39 pmDSM-SAV

4h 36m1 stop

$280American Airlines

Find Deal

mar., nov. 4 - sam., nov. 15

1:20 pm - 9:35 pmSAV-DSM

9h 15m2 stops

5:25 am - 4:45 pmDSM-SAV

10h 20m2 stops

$290Southwest

Find Deal

mar., nov. 4 - sam., nov. 15

5:30 am - 10:05 amGSP-DSM

5h 35m1 stop

6:39 pm - 11:55 pmDSM-GSP

4h 16m1 stop

$316Delta

Find Deal

jeu., oct. 30 - dim., nov. 2

6:40 am - 10:05 amSAV-DSM

4h 25m1 stop

6:39 pm - 11:43 pmDSM-SAV

4h 04m1 stop

$323Delta

Find Deal

mar., nov. 4 - ven., nov. 7

6:15 am - 11:00 amCHS-DSM

5h 45m2 stops

6:20 am - 4:25 pmDSM-CHS

9h 05m2 stops

$325Southwest

Find Deal

jeu., oct. 16 - mer., oct. 22

Delta flights from South Carolina to Des Moines

Our best Delta deals on South Carolina to Des Moines flight tickets

Delta

Oct 30

GSP5:30 amGreenville

5h 35m

1 stop

DSM10:05 amDes Moines

Nov 2

DSM6:39 pmDes Moines

4h 16m

1 stop

GSP11:55 pmGreenville

$316

Find similar

Delta

Nov 4

SAV6:40 amSavannah/Hilton Head

4h 25m

1 stop

DSM10:05 amDes Moines

Nov 7

DSM6:39 pmDes Moines

4h 04m

1 stop

SAV11:43 pmSavannah/Hilton Head

$323

Find similar

Delta

Feb 20

SAV1:00 pmSavannah/Hilton Head

8h 03m

1 stop

DSM8:03 pmDes Moines

Feb 23

DSM6:20 amDes Moines

11h 24m

2 stops

SAV6:44 pmSavannah/Hilton Head

$324

Find similar

United Airlines flights from South Carolina to Des Moines

Our best United Airlines deals on South Carolina to Des Moines flight tickets

United Airlines

Nov 8

CAE2:29 pmColumbia Metropolitan

10h 15m

2 stops

DSM11:44 pmDes Moines

Nov 15

DSM3:15 pmDes Moines

5h 15m

1 stop

CAE9:30 pmColumbia Metropolitan

$254

Find similar

United Airlines

Nov 8

CAE2:29 pmColumbia Metropolitan

10h 15m

2 stops

DSM11:44 pmDes Moines

Nov 15

DSM9:01 amDes Moines

11h 29m

2 stops

CAE9:30 pmColumbia Metropolitan

$259

Find similar

United Airlines

Nov 4

SAV10:00 amSavannah/Hilton Head

5h 19m

1 stop

DSM2:19 pmDes Moines

Nov 15

DSM9:01 amDes Moines

11h 32m

2 stops

SAV9:33 pmSavannah/Hilton Head

$285

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jeu. 10/30

5:08 pm-2:50 pm

1 stop22h 42m

Des Moines

lun. 11/3

8:30 am-8:15 pm

1 stop10h 45m

$195

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

ven. 11/14

12:36 pm-5:08 pm

1 stop5h 32m

Des Moines

dim. 11/16

2:32 pm-5:17 pm

1 stop25h 45m

$203

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

sam. 11/8

9:00 am-3:33 pm

1 stop7h 33m

Des Moines

sam. 11/15

3:39 pm-10:52 pm

1 stop6h 13m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

sam. 11/8

2:29 pm-11:44 pm

2 stops10h 15m

Des Moines

sam. 11/15

3:15 pm-9:30 pm

1 stop5h 15m

$254

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

sam. 11/8

2:29 pm-11:44 pm

2 stops10h 15m

Des Moines

sam. 11/15

9:01 am-9:30 pm

2 stops11h 29m

$259

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

mar. 11/4

3:52 pm-10:59 pm

1 stop8h 07m

Des Moines

sam. 11/15

4:03 pm-9:39 pm

1 stop4h 36m

$280

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

mar. 11/4

1:20 pm-9:35 pm

2 stops9h 15m

Des Moines

sam. 11/15

5:25 am-4:45 pm

2 stops10h 20m

$290

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jeu. 10/30

5:30 am-10:05 am

1 stop5h 35m

Des Moines

dim. 11/2

6:39 pm-11:55 pm

1 stop4h 16m

$316

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

mar. 11/4

6:40 am-10:05 am

1 stop4h 25m

Des Moines

ven. 11/7

6:39 pm-11:43 pm

1 stop4h 04m

$323

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jeu. 10/16

6:15 am-11:00 am

2 stops5h 45m

Des Moines

mer. 10/22

6:20 am-4:25 pm

2 stops9h 05m

$325

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then May is your next best option. Flight prices from South Carolina to Des Moines during May average around $307.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from South Carolina to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $321. Flights from South Carolina to Des Moines on a Saturday will generally be more expensive and average around $594. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from South Carolina to Des Moines in the afternoon for as low as $411. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $485. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap South Carolina to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Des Moines

Fastest flight time	2h 28m
Direct flights	Every day
Airports in Des Moines	1 airport

The fastest flight from South Carolina to Des Moines takes 2h 28m

Direct flights go from South Carolina to Des Moines every day.

There is 1 airport near Des Moines: Des Moines (DSM)

Search flight deals

When did momondo last update prices for flights from South Carolina to Des Moines Airport?
Prices for flights from South Carolina to Des Moines Airport refresh daily.
How many operators does momondo search for flights from South Carolina to Des Moines Airport?
There are 3 operators available for flights from South Carolina to Des Moines Airport as of September 2025.
How old do you have to be to fly from South Carolina to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Des Moines

Compare and see reviews for airlines that fly from South Carolina to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $216	Free Cancellation	Rating 7.9 7,973 reviews	Search Delta flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $326	Free Cancellation	Rating 7.4 8,926 reviews	Search United Airlines flights

West Des Moines

Ames

Ankeny

Altoona

Clive

Urbandale

Pella

Newton

Osceola

Johnston

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from South Carolina.

Can I find flights from South Carolina to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Des Moines.

I’m not ready to book a flight from South Carolina to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

sam. 10/25

sam. 11/1

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States

Airports servicing Iowa

Sioux City Sioux Gateway Airport

Popular cities in the United States

Flights to New Yorkfrom $50

Flights to Los Angelesfrom $49

Flights to Miamifrom $52

Flights to Chicagofrom $65

Flights to Orlandofrom $57

Flights to Las Vegasfrom $47

Flights to San Franciscofrom $59

Flights to Washington, D.C.from $60

Flights to Bostonfrom $68

Flights to Atlantafrom $51

Flights to Dallasfrom $60

Flights to Seattlefrom $86

Cheap flights from South Carolina to Des Moines from $112

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Des Moines departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from South Carolina to Des Moines

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Cheap direct flights

Delta flights from South Carolina to Des Moines

Our best Delta deals on South Carolina to Des Moines flight tickets

United Airlines flights from South Carolina to Des Moines

Our best United Airlines deals on South Carolina to Des Moines flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

See travel insights to Des Moines from

How to get the cheapest flight ticket from South Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then May is your next best option. Flight prices from South Carolina to Des Moines during May average around $307.

What is the cheapest day to depart on your flight to Des Moines?

What is the cheapest time of day to depart on your flight to Des Moines?

What is the cheapest airline that flies from South Carolina to Des Moines?

United Airlines, Delta, and Frontier are the most popular carriers operating from South Carolina to Des Moines

What airlines fly to Des Moines?

How many flights depart from South Carolina to Des Moines on average per week?

As of September 2025, there are 14 flights per week flying from South Carolina to Des Moines. The most common day of the week flights depart is Mon, with 14% of flights taking off on this day.

How long does it take to fly to Des Moines?

If you’re flying from a popular airport in South Carolina, such as Greenville or Columbia, and flying into Des Moines, then you can expect flight times to average 4h 25m and 4h 53m, respectively.

Cheap South Carolina to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Des Moines

Fastest flight time

Direct flights

Airports in Des Moines

When did momondo last update prices for flights from South Carolina to Des Moines Airport?

How many operators does momondo search for flights from South Carolina to Des Moines Airport?

How old do you have to be to fly from South Carolina to Des Moines Airport?

What documentation or ID do you need to fly to Des Moines Airport?

Best airlines flying from South Carolina to Des Moines

Compare and see reviews for airlines that fly from South Carolina to Des Moines with momondo

Traveling to a place near Des Moines?

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Des Moines?

Can I find flights from South Carolina to Des Moines with flexible booking policies on momondo?

How can momondo help me find flights from South Carolina to Des Moines?

I’m not ready to book a flight from South Carolina to Des Moines right now. Can momondo alert me if prices change?

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Iowa