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Cheap flights from South Carolina to Des Moines from $92

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Des Moines departing on 5/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:58 pm - 8:37 am
CLT
-
DSM
13h 39m
1 stop
Multiple Airlines Logo
4:07 pm - 12:05 pm
DSM
-
CLT
18h 58m
1 stop
$203Multiple Airlines
Wed, Jun 3 - Mon, Jun 8
Multiple Airlines Logo
1:00 pm - 10:31 pm
CLT
-
DSM
10h 31m
1 stop
Multiple Airlines Logo
4:41 pm - 10:03 am
DSM
-
CLT
16h 22m
1 stop
$213Multiple Airlines
Thu, May 21 - Sun, May 24
American Airlines Logo
6:00 am - 1:20 pm
CAE
-
DSM
8h 20m
1 stop
American Airlines Logo
7:11 am - 4:51 pm
DSM
-
CAE
8h 40m
1 stop
$329American Airlines
Sat, May 9 - Mon, May 11
United Airlines Logo
5:08 pm - 9:24 pm
CHS
-
DSM
5h 16m
1 stop
United Airlines Logo
8:15 am - 4:11 pm
DSM
-
CHS
6h 56m
1 stop
$335United Airlines
Wed, May 6 - Wed, May 13
Delta Logo
11:41 am - 5:54 pm
MYR
-
DSM
7h 13m
1 stop
Delta Logo
6:39 pm - 11:59 pm
DSM
-
MYR
4h 20m
1 stop
$335Delta
Wed, Jun 17 - Tue, Jun 23
United Airlines Logo
3:14 pm - 9:24 pm
MYR
-
DSM
7h 10m
1 stop
United Airlines Logo
6:15 am - 2:18 pm
DSM
-
MYR
7h 03m
1 stop
$336United Airlines
Wed, May 6 - Sat, May 9
Delta Logo
5:40 am - 11:08 am
GSP
-
DSM
6h 28m
1 stop
Delta Logo
7:34 am - 2:50 pm
DSM
-
GSP
6h 16m
1 stop
$336Delta
Sat, May 9 - Tue, May 12
American Airlines Logo
6:00 am - 12:55 pm
CAE
-
DSM
7h 55m
1 stop
American Airlines Logo
7:11 am - 4:51 pm
DSM
-
CAE
8h 40m
1 stop
$339American Airlines
Thu, Apr 30 - Mon, May 4
Southwest Logo
1:15 pm - 9:15 pm
CHS
-
DSM
9h 00m
2 stops
Southwest Logo
3:15 pm - 9:05 pm
DSM
-
CHS
4h 50m
1 stop
$340Southwest
Wed, May 6 - Tue, May 12
Southwest Logo
4:05 pm - 10:10 pm
MYR
-
DSM
7h 05m
2 stops
Southwest Logo
5:35 am - 11:05 am
DSM
-
MYR
4h 30m
1 stop
$341Southwest
Wed, May 6 - Sat, May 9

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Delta flights from South Carolina to Des Moines

Our best Delta deals on South Carolina to Des Moines flight tickets
Delta
Jun 17
MYR11:41 amMyrtle Beach Intl
7h 13m
1 stop
DSM5:54 pmDes Moines
Jun 23
DSM6:39 pmDes Moines
4h 20m
1 stop
MYR11:59 pmMyrtle Beach Intl
$335
Delta
May 9
GSP5:40 amGreenville
6h 28m
1 stop
DSM11:08 amDes Moines
May 12
DSM7:34 amDes Moines
6h 16m
1 stop
GSP2:50 pmGreenville
$336
Delta
May 7
CAE6:40 amColumbia Metropolitan
5h 28m
1 stop
DSM11:08 amDes Moines
May 9
DSM5:27 amDes Moines
6h 47m
1 stop
CAE1:14 pmColumbia Metropolitan
$364

United Airlines flights from South Carolina to Des Moines

Our best United Airlines deals on South Carolina to Des Moines flight tickets
United Airlines
May 6
CHS5:08 pmCharleston
5h 16m
1 stop
DSM9:24 pmDes Moines
May 13
DSM8:15 amDes Moines
6h 56m
1 stop
CHS4:11 pmCharleston
$335
United Airlines
May 6
MYR3:14 pmMyrtle Beach Intl
7h 10m
1 stop
DSM9:24 pmDes Moines
May 9
DSM6:15 amDes Moines
7h 03m
1 stop
MYR2:18 pmMyrtle Beach Intl
$336
United Airlines
May 9
GSP10:40 amGreenville
4h 44m
1 stop
DSM2:24 pmDes Moines
May 16
DSM3:20 pmDes Moines
6h 38m
1 stop
GSP10:58 pmGreenville
$337

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 6/3

7:58 pm-8:37 am

1 stop13h 39m

Des Moines

Mon 6/8

4:07 pm-12:05 pm

1 stop18h 58m

$203

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 5/21

1:00 pm-10:31 pm

1 stop10h 31m

Des Moines

Sun 5/24

4:41 pm-10:03 am

1 stop16h 22m

$213

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Sat 5/9

6:00 am-1:20 pm

1 stop8h 20m

Des Moines

Mon 5/11

7:11 am-4:51 pm

1 stop8h 40m

$329

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/6

5:08 pm-9:24 pm

1 stop5h 16m

Des Moines

Wed 5/13

8:15 am-4:11 pm

1 stop6h 56m

$335
Quickest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

11:41 am-5:54 pm

1 stop7h 13m

Des Moines

Tue 6/23

6:39 pm-11:59 pm

1 stop4h 20m

$335

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 5/6

3:14 pm-9:24 pm

1 stop7h 10m

Des Moines

Sat 5/9

6:15 am-2:18 pm

1 stop7h 03m

$336

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

5:40 am-11:08 am

1 stop6h 28m

Des Moines

Tue 5/12

7:34 am-2:50 pm

1 stop6h 16m

$336

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 4/30

6:00 am-12:55 pm

1 stop7h 55m

Des Moines

Mon 5/4

7:11 am-4:51 pm

1 stop8h 40m

$339

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/6

1:15 pm-9:15 pm

2 stops9h 00m

Des Moines

Tue 5/12

3:15 pm-9:05 pm

1 stop4h 50m

$340

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 5/6

4:05 pm-10:10 pm

2 stops7h 05m

Des Moines

Sat 5/9

5:35 am-11:05 am

1 stop4h 30m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from South Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in April, then February is your next best option. Flight prices from South Carolina to Des Moines during February average around $317.

Frequently asked questions about flying from South Carolina to Des Moines

  • When did momondo last update prices for flights from South Carolina to Des Moines Airport?

    Prices for flights from South Carolina to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Des Moines Airport?

  • How old do you have to be to fly from South Carolina to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Des Moines

Compare and see reviews for airlines that fly from South Carolina to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
8,406 reviews
Search Delta flights
American AirlinesPriceFrom $216Free CancellationRating
7.1
11,593 reviews
Search American Airlines flights
United AirlinesPriceFrom $326Free CancellationRating
7.4
9,602 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from South Carolina.

Can I find flights from South Carolina to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Des Moines.

I’m not ready to book a flight from South Carolina to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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