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Cheap flights from South Carolina to Des Moines from $69

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Des Moines departing on 1/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
9:43 pm - 10:19 amCLT-DSM
13h 36m1 stop
Frontier Logo
10:17 am - 8:38 pmDSM-CLT
9h 21m1 stop
$208Frontier
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Mon, Dec 22 - Sun, Jan 4
Multiple Airlines Logo
12:12 pm - 6:41 pmCLT-DSM
7h 29m1 stop
Multiple Airlines Logo
8:38 pm - 8:26 amDSM-CLT
34h 48m2 stops
$240Multiple Airlines
Find Deal
Thu, Feb 19 - Mon, Feb 23
Delta Logo
5:34 am - 10:38 amCAE-DSM
6h 04m1 stop
Delta Logo
5:34 am - 12:08 pmDSM-CAE
5h 34m1 stop
$249Delta
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Sun, Dec 7 - Sun, Dec 14
Delta Logo
5:34 am - 2:19 pmCAE-DSM
9h 45m2 stops
Delta Logo
5:34 am - 12:08 pmDSM-CAE
5h 34m1 stop
$254Delta
Find Deal
Sun, Dec 7 - Sun, Dec 14
Multiple Airlines Logo
8:55 pm - 9:48 amCLT-DSM
13h 53m1 stop
Multiple Airlines Logo
4:30 pm - 3:10 pmDSM-CLT
21h 40m2 stops
$263Multiple Airlines
Find Deal
Fri, Dec 12 - Sun, Jan 18
Delta Logo
7:10 am - 12:24 pmCAE-DSM
6h 14m1 stop
Delta Logo
6:32 pm - 11:31 pmDSM-CAE
3h 59m1 stop
$275Delta
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Thu, Nov 27 - Mon, Dec 1
American Airlines Logo
8:00 pm - 12:21 amCAE-DSM
5h 21m1 stop
American Airlines Logo
3:18 pm - 11:10 pmDSM-CAE
6h 52m1 stop
$279American Airlines
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Fri, Nov 28 - Tue, Dec 2
American Airlines Logo
8:00 pm - 12:21 amCAE-DSM
5h 21m1 stop
American Airlines Logo
6:00 am - 4:53 pmDSM-CAE
9h 53m2 stops
$284American Airlines
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Fri, Nov 28 - Tue, Dec 2
Allegiant Air Logo
4:05 pm - 10:26 pmGSP-DSM
7h 21m1 stop
Allegiant Air Logo
7:15 am - 2:35 pmDSM-GSP
6h 20m1 stop
$309Allegiant Air
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Thu, Dec 18 - Sun, Dec 21
Allegiant Air Logo
4:32 pm - 4:36 pmGSP-DSM
25h 04m1 stop
Allegiant Air Logo
8:00 am - 9:20 pmDSM-GSP
12h 20m1 stop
$321Allegiant Air
Find Deal
Thu, Nov 27 - Mon, Dec 1

Delta flights from South Carolina to Des Moines

Our best Delta deals on South Carolina to Des Moines flight tickets
Delta
Dec 7
CAE5:34 amColumbia Metropolitan
6h 04m
1 stop
DSM10:38 amDes Moines
Dec 14
DSM5:34 amDes Moines
5h 34m
1 stop
CAE12:08 pmColumbia Metropolitan
$249
Find similar
Delta
Dec 7
CAE5:34 amColumbia Metropolitan
9h 45m
2 stops
DSM2:19 pmDes Moines
Dec 14
DSM5:34 amDes Moines
5h 34m
1 stop
CAE12:08 pmColumbia Metropolitan
$254
Find similar
Delta
Nov 27
CAE7:10 amColumbia Metropolitan
6h 14m
1 stop
DSM12:24 pmDes Moines
Dec 1
DSM6:32 pmDes Moines
3h 59m
1 stop
CAE11:31 pmColumbia Metropolitan
$275
Find similar

American Airlines flights from South Carolina to Des Moines

Our best American Airlines deals on South Carolina to Des Moines flight tickets
American Airlines
Nov 28
CAE8:00 pmColumbia Metropolitan
5h 21m
1 stop
DSM12:21 amDes Moines
Dec 2
DSM3:18 pmDes Moines
6h 52m
1 stop
CAE11:10 pmColumbia Metropolitan
$279
Find similar
American Airlines
Nov 28
CAE8:00 pmColumbia Metropolitan
5h 21m
1 stop
DSM12:21 amDes Moines
Dec 2
DSM6:00 amDes Moines
9h 53m
2 stops
CAE4:53 pmColumbia Metropolitan
$284
Find similar
American Airlines
Dec 3
GSP12:17 pmGreenville
5h 18m
1 stop
DSM4:35 pmDes Moines
Jan 6
DSM4:25 pmDes Moines
6h 20m
1 stop
GSP11:45 pmGreenville
$317
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Mon 12/22

9:43 pm-10:19 am

1 stop13h 36m

Des Moines

Sun 1/4

10:17 am-8:38 pm

1 stop9h 21m

$208

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 2/19

12:12 pm-6:41 pm

1 stop7h 29m

Des Moines

Mon 2/23

8:38 pm-8:26 am

2 stops34h 48m

$240

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Sun 12/7

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Sun 12/14

5:34 am-12:08 pm

1 stop5h 34m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Sun 12/7

5:34 am-2:19 pm

2 stops9h 45m

Des Moines

Sun 12/14

5:34 am-12:08 pm

1 stop5h 34m

$254

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 12/12

8:55 pm-9:48 am

1 stop13h 53m

Des Moines

Sun 1/18

4:30 pm-3:10 pm

2 stops21h 40m

$263

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 11/27

7:10 am-12:24 pm

1 stop6h 14m

Des Moines

Mon 12/1

6:32 pm-11:31 pm

1 stop3h 59m

$275

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Fri 11/28

8:00 pm-12:21 am

1 stop5h 21m

Des Moines

Tue 12/2

3:18 pm-11:10 pm

1 stop6h 52m

$279

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Fri 11/28

8:00 pm-12:21 am

1 stop5h 21m

Des Moines

Tue 12/2

6:00 am-4:53 pm

2 stops9h 53m

$284

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 12/18

4:05 pm-10:26 pm

1 stop7h 21m

Des Moines

Sun 12/21

7:15 am-2:35 pm

1 stop6h 20m

$309

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 11/27

4:32 pm-4:36 pm

1 stop25h 04m

Des Moines

Mon 12/1

8:00 am-9:20 pm

1 stop12h 20m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from South Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then May is your next best option. Flight prices from South Carolina to Des Moines during May average around $307.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from South Carolina to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $321. Flights from South Carolina to Des Moines on a Saturday will generally be more expensive and average around $594. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from South Carolina to Des Moines in the afternoon for as low as $411. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $485. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap South Carolina to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Des Moines

Fastest flight time

2h 31m

Direct flights

Mon, Tue, Wed, Thu, Fri and Sun

Airports in Des Moines

1 airport
The fastest flight from South Carolina to Des Moines takes 2h 31m
Direct flights go from South Carolina to Des Moines on Monday, Tuesday, Wednesday, Thursday, Friday and Sunday. There are no airlines offering direct flights.
There is 1 airport near Des Moines: Des Moines (DSM)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Des Moines Airport?

    Prices for flights from South Carolina to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Des Moines Airport?

  • How old do you have to be to fly from South Carolina to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Des Moines

Compare and see reviews for airlines that fly from South Carolina to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
United AirlinesPriceFrom $326Free CancellationRating
7.4
9,017 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Newton
Pella
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from South Carolina.

Can I find flights from South Carolina to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Des Moines.

I’m not ready to book a flight from South Carolina to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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