What airlines fly to Des Moines?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Des Moines from South Carolina according to our data. Delta is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

How long does it take to fly to Des Moines?

If you’re flying from a popular airport in South Carolina, such as Greenville or Myrtle Beach, and flying into Des Moines, then you can expect flight times to average 4h 38m and 5h 14m, respectively.

What is the cheapest airline that flies from South Carolina to Des Moines?

American Airlines, Delta, and Southwest are the most popular carriers operating from South Carolina to Des Moines

How many flights depart from South Carolina to Des Moines on average per week?

As of March 2026, there are 10 flights per week flying from South Carolina to Des Moines. The most common day of the week flights depart is Mon, with 20% of flights taking off on this day.

When did momondo last update prices for flights from South Carolina to Des Moines Airport?

Prices for flights from South Carolina to Des Moines Airport refresh daily.

How many operators does momondo search for flights from South Carolina to Des Moines Airport?

There are 3 operators available for flights from South Carolina to Des Moines Airport as of March 2026.

How old do you have to be to fly from South Carolina to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$84 Cheap Flights from South Carolina to Des Moines in 2026

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Find the cheapest flights from South Carolina to Des Moines

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:18 pm - 1:09 pm

CLT

DSM

19h 51m

1 stop

2:04 pm - 6:54 pm

DSM

CLT

27h 50m

1 stop

$162Frontier

ה', אפר' 16 - ב', אפר' 20

6:18 pm - 1:09 pm

CLT

DSM

19h 51m

1 stop

2:04 pm - 6:54 pm

DSM

CLT

27h 50m

1 stop

$214Frontier

ה', אפר' 16 - ב', אפר' 20

6:18 pm - 1:09 pm

CLT

DSM

19h 51m

1 stop

8:30 am - 10:33 pm

DSM

CLT

13h 03m

1 stop

$218Multiple Airlines

ה', אפר' 23 - א', אפר' 26

6:18 pm - 1:09 pm

CLT

DSM

19h 51m

1 stop

6:48 pm - 2:13 pm

DSM

CLT

18h 25m

2 stops

$219Multiple Airlines

ה', אפר' 16 - ב', אפר' 20

5:40 pm - 9:18 pm

GSP

DSM

4h 38m

1 stop

11:40 am - 4:59 pm

DSM

GSP

4h 19m

1 stop

$285United Airlines

ג', מאי 5 - ג', מאי 12

6:00 am - 2:24 pm

GSP

DSM

9h 24m

2 stops

6:15 am - 2:10 pm

DSM

GSP

6h 55m

1 stop

$290United Airlines

ג', מאי 5 - ג', מאי 12

1:55 pm - 10:10 pm

GSP

DSM

9h 15m

2 stops

5:30 am - 4:20 pm

DSM

GSP

9h 50m

2 stops

$297Southwest

ג', מאי 5 - ג', מאי 12

7:30 am - 11:30 am

GSP

DSM

5h 00m

1 stop

2:16 pm - 7:46 pm

DSM

GSP

4h 30m

1 stop

$301American Airlines

ש', מאי 9 - ג', מאי 12

5:20 am - 1:46 pm

GSP

DSM

9h 26m

2 stops

11:09 am - 7:46 pm

DSM

GSP

7h 37m

1 stop

$306American Airlines

ש', מאי 9 - ג', מאי 12

7:40 am - 11:45 am

CHS

DSM

5h 05m

1 stop

4:20 pm - 10:10 pm

DSM

CHS

4h 50m

1 stop

$370Southwest

ו', אפר' 24 - א', אפר' 26

Frontier flights from South Carolina to Des Moines

Our best Frontier deals on South Carolina to Des Moines flight tickets

Frontier

Apr 16

CLT6:18 pmCharlotte Douglas

19h 51m

1 stop

DSM1:09 pmDes Moines

Apr 20

DSM2:04 pmDes Moines

27h 50m

1 stop

CLT6:54 pmCharlotte Douglas

$162

Frontier

Apr 16

CLT8:17 pmCharlotte Douglas

17h 52m

2 stops

DSM1:09 pmDes Moines

Apr 20

DSM2:04 pmDes Moines

27h 50m

1 stop

CLT6:54 pmCharlotte Douglas

$233

Frontier

Mar 16

CLT9:28 pmCharlotte Douglas

13h 17m

1 stop

DSM9:45 amDes Moines

Mar 19

DSM10:40 amDes Moines

5h 28m

1 stop

CLT5:08 pmCharlotte Douglas

$234

Delta flights from South Carolina to Des Moines

Our best Delta deals on South Carolina to Des Moines flight tickets

Delta

Jul 1

CAE5:40 amColumbia Metropolitan

5h 34m

1 stop

DSM10:14 amDes Moines

Jul 4

DSM5:45 amDes Moines

5h 43m

1 stop

CAE12:28 pmColumbia Metropolitan

$269

Delta

Apr 22

SAV6:50 amSavannah/Hilton Head

5h 15m

1 stop

DSM11:05 amDes Moines

Apr 22

DSM6:31 pmDes Moines

4h 28m

1 stop

SAV11:59 pmSavannah/Hilton Head

$317

Delta

Apr 18

GSP5:40 amGreenville

6h 25m

1 stop

DSM11:05 amDes Moines

Apr 27

DSM2:44 pmDes Moines

6h 29m

1 stop

GSP10:13 pmGreenville

$318

Fly from

Fly to

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

ה' 4/16

6:18 pm-1:09 pm

1 stop19h 51m

Des Moines

ב' 4/20

2:04 pm-6:54 pm

1 stop27h 50m

$162

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

ה' 4/16

6:18 pm-1:09 pm

1 stop19h 51m

Des Moines

ב' 4/20

2:04 pm-6:54 pm

1 stop27h 50m

$214

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

ה' 4/23

6:18 pm-1:09 pm

1 stop19h 51m

Des Moines

א' 4/26

8:30 am-10:33 pm

1 stop13h 03m

$218

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

ה' 4/16

6:18 pm-1:09 pm

1 stop19h 51m

Des Moines

ב' 4/20

6:48 pm-2:13 pm

2 stops18h 25m

$219

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

ג' 5/5

5:40 pm-9:18 pm

1 stop4h 38m

Des Moines

ג' 5/12

11:40 am-4:59 pm

1 stop4h 19m

$285

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

ג' 5/5

6:00 am-2:24 pm

2 stops9h 24m

Des Moines

ג' 5/12

6:15 am-2:10 pm

1 stop6h 55m

$290

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

ג' 5/5

1:55 pm-10:10 pm

2 stops9h 15m

Des Moines

ג' 5/12

5:30 am-4:20 pm

2 stops9h 50m

$297

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

ש' 5/9

7:30 am-11:30 am

1 stop5h 00m

Des Moines

ג' 5/12

2:16 pm-7:46 pm

1 stop4h 30m

$301

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

ש' 5/9

5:20 am-1:46 pm

2 stops9h 26m

Des Moines

ג' 5/12

11:09 am-7:46 pm

1 stop7h 37m

$306

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

ו' 4/24

7:40 am-11:45 am

1 stop5h 05m

Des Moines

א' 4/26

4:20 pm-10:10 pm

1 stop4h 50m

$370

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

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Other information

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in May, then January is your next best option. Flight prices from South Carolina to Des Moines during January average around $321.

Cheap South Carolina to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Des Moines

Fastest flight time	2h 30m
Direct flights	Every day
Airports in Des Moines	1 airport

The fastest flight from South Carolina to Des Moines takes 2h 30m

Direct flights go from South Carolina to Des Moines every day.

There is 1 airport in Des Moines. From South Carolina there are direct flights to Des Moines (DSM).

Search flight deals

When did momondo last update prices for flights from South Carolina to Des Moines Airport?
Prices for flights from South Carolina to Des Moines Airport refresh daily.
How many operators does momondo search for flights from South Carolina to Des Moines Airport?
There are 3 operators available for flights from South Carolina to Des Moines Airport as of March 2026.
How old do you have to be to fly from South Carolina to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Des Moines

Compare and see reviews for airlines that fly from South Carolina to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $208	Free Cancellation	Rating 7.9 8,244 reviews	Search Delta flights
American Airlines	PriceFrom $216	Free Cancellation	Rating 7.1 11,370 reviews	Search American Airlines flights
United Airlines	PriceFrom $326	Free Cancellation	Rating 7.4 9,370 reviews	Search United Airlines flights

West Des Moines

Ames

Ankeny

Altoona

Clive

Pella

Urbandale

Johnston

Newton

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from South Carolina.

Can I find flights from South Carolina to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Des Moines.

I’m not ready to book a flight from South Carolina to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of South Carolina to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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Cheap flights from South Carolina to Des Moines from $84

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Des Moines departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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What airlines fly to Des Moines?

How many flights depart from South Carolina to Des Moines on average per week?

How long does it take to fly to Des Moines?

Cheap South Carolina to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Des Moines

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An easier way to manage your Des Moines trip

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List of cabin classes available on flights landing in Des Moines. Availability may vary depending on flight origin and airline.

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