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Cheap flights from Santo Domingo to Charleston from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Charleston departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santo Domingo to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:27 pm - 5:29 am
CHS
-
SDQ
15h 02m
1 stop
$405Multiple Airlines
Tue, Jun 2 - Sat, Jun 20
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:27 pm - 5:29 am
CHS
-
SDQ
15h 02m
1 stop
$411Multiple Airlines
Wed, Jun 3 - Sat, Jun 20
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:27 pm - 5:29 am
CHS
-
SDQ
15h 02m
1 stop
$416Multiple Airlines
Mon, Jun 1 - Sat, Jun 20
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:27 pm - 4:30 pm
CHS
-
SDQ
26h 03m
1 stop
$427Multiple Airlines
Tue, Jun 2 - Thu, Jun 18
United Airlines Logo
3:20 pm - 11:59 pm
SDQ
-
CHS
8h 39m
1 stop
United Airlines Logo
3:34 pm - 10:46 pm
CHS
-
SDQ
7h 12m
1 stop
$429United Airlines
Fri, May 15 - Wed, May 27
United Airlines Logo
3:20 pm - 11:59 pm
SDQ
-
CHS
8h 39m
1 stop
United Airlines Logo
7:00 am - 2:10 pm
CHS
-
SDQ
7h 10m
1 stop
$430United Airlines
Fri, May 15 - Mon, Aug 31
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:27 pm - 4:30 pm
CHS
-
SDQ
26h 03m
1 stop
$433Multiple Airlines
Wed, Jun 3 - Thu, Jun 18
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:39 pm - 4:29 pm
CHS
-
SDQ
25h 50m
2 stops
$436Multiple Airlines
Tue, Jun 2 - Tue, Jun 16
Multiple Airlines Logo
6:10 am - 1:44 pm
SDQ
-
CHS
7h 34m
1 stop
Multiple Airlines Logo
2:27 pm - 4:30 pm
CHS
-
SDQ
26h 03m
1 stop
$438Multiple Airlines
Mon, Jun 1 - Thu, Jun 18
JetBlue Logo
3:08 am - 4:57 pm
SDQ
-
CHS
13h 49m
1 stop
JetBlue Logo
10:39 am - 5:33 pm
CHS
-
SDQ
6h 54m
1 stop
$439JetBlue
Sun, May 10 - Tue, May 26

American Airlines flights from Santo Domingo to Charleston

Our best American Airlines deals on Santo Domingo to Charleston flight tickets
American Airlines
May 1
SDQ6:00 amSanto Domingo Las Americas
13h 37m
1 stop
CHS7:37 pmCharleston
May 4
CHS8:09 pmCharleston
13h 11m
1 stop
SDQ9:20 amSanto Domingo Las Americas
$443
American Airlines
Jul 7
SDQ7:45 pmSanto Domingo Las Americas
16h 34m
2 stops
CHS12:19 pmCharleston
Jul 27
CHS7:12 pmCharleston
17h 45m
1 stop
SDQ12:57 pmSanto Domingo Las Americas
$448
American Airlines
Apr 27
SDQ5:55 pmSanto Domingo Las Americas
16h 39m
1 stop
CHS10:34 amCharleston
May 4
CHS8:09 pmCharleston
20h 46m
1 stop
SDQ4:55 pmSanto Domingo Las Americas
$452

JetBlue flights from Santo Domingo to Charleston

Our best JetBlue deals on Santo Domingo to Charleston flight tickets
JetBlue
May 10
SDQ3:08 amSanto Domingo Las Americas
13h 49m
1 stop
CHS4:57 pmCharleston
May 26
CHS10:39 amCharleston
6h 54m
1 stop
SDQ5:33 pmSanto Domingo Las Americas
$439
JetBlue
Jun 1
SDQ5:01 amSanto Domingo Las Americas
13h 09m
1 stop
CHS6:10 pmCharleston
Jun 15
CHS10:46 amCharleston
10h 49m
1 stop
SDQ9:35 pmSanto Domingo Las Americas
$447
JetBlue
May 30
SDQ3:10 amSanto Domingo Las Americas
11h 56m
1 stop
CHS3:06 pmCharleston
Jun 16
CHS10:46 amCharleston
7h 45m
1 stop
SDQ6:31 pmSanto Domingo Las Americas
$463

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Santo Domingo to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Tue 6/2

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Sat 6/20

2:27 pm-5:29 am

1 stop15h 02m

$405

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 6/3

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Sat 6/20

2:27 pm-5:29 am

1 stop15h 02m

$411

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 6/1

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Sat 6/20

2:27 pm-5:29 am

1 stop15h 02m

$416

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Tue 6/2

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Thu 6/18

2:27 pm-4:30 pm

1 stop26h 03m

$427

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/15

3:20 pm-11:59 pm

1 stop8h 39m

Charleston

Wed 5/27

3:34 pm-10:46 pm

1 stop7h 12m

$429
Quickest round-trip

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/15

3:20 pm-11:59 pm

1 stop8h 39m

Charleston

Mon 8/31

7:00 am-2:10 pm

1 stop7h 10m

$430

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 6/3

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Thu 6/18

2:27 pm-4:30 pm

1 stop26h 03m

$433

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Tue 6/2

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Tue 6/16

2:39 pm-4:29 pm

2 stops25h 50m

$436

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 6/1

6:10 am-1:44 pm

1 stop7h 34m

Charleston

Thu 6/18

2:27 pm-4:30 pm

1 stop26h 03m

$438

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sun 5/10

3:08 am-4:57 pm

1 stop13h 49m

Charleston

Tue 5/26

10:39 am-5:33 pm

1 stop6h 54m

$439

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Santo Domingo to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Santo Domingo Las Americas to Charleston?

Delta and American Airlines are the most popular carriers operating from Santo Domingo Las Americas to Charleston

When to book flights from Santo Domingo to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Charleston (SDQ to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Charleston

Fastest flight time

8h 08m

Direct flights

None
The fastest flight from Santo Domingo to Charleston takes 8h 08m
There are no direct flights from Santo Domingo to Charleston. There are no popular flight routes from Santo Domingo to Charleston.
Search flight deals

Frequently asked questions about flying from Santo Domingo to Charleston

  • How far is Santo Domingo Las Americas to Charleston by plane?

    A flight from Santo Domingo Las Americas to Charleston will travel around 1165.2 mi. Flights usually cover this in 8h 08m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Charleston Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Charleston Airport refresh daily.

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Charleston Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santo Domingo Las Americas Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
Summerville
Kiawah Island
North Charleston
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Charleston?

It is quick and easy to find Santo Domingo to Charleston flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Charleston that suits you.

Can I find flights from Santo Domingo to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santo Domingo to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Santo Domingo to Charleston?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Charleston from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Santo Domingo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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