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Cheap flights from Santo Domingo to Charleston from $147

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Charleston departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santo Domingo to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:55 pm - 12:24 am
SDQ
-
CHS
6h 29m
1 stop
American Airlines Logo
8:09 pm - 9:20 am
CHS
-
SDQ
13h 11m
1 stop
$357American Airlines
Wed, Apr 29 - Sun, May 17
American Airlines Logo
7:38 pm - 10:13 am
SDQ
-
CHS
14h 35m
1 stop
American Airlines Logo
5:50 am - 3:25 pm
CHS
-
SDQ
9h 35m
1 stop
$366American Airlines
Mon, Jul 27 - Tue, Aug 18
American Airlines Logo
5:55 pm - 10:34 am
SDQ
-
CHS
16h 39m
1 stop
American Airlines Logo
8:43 pm - 10:55 am
CHS
-
SDQ
14h 12m
2 stops
$369American Airlines
Thu, May 14 - Tue, Sep 15
American Airlines Logo
7:38 pm - 10:13 am
SDQ
-
CHS
14h 35m
1 stop
American Airlines Logo
6:50 am - 6:20 pm
CHS
-
SDQ
11h 30m
2 stops
$370American Airlines
Mon, Jul 27 - Tue, Aug 18
Spirit Airlines Logo
2:52 am - 10:13 pm
SDQ
-
CHS
19h 21m
1 stop
Spirit Airlines Logo
8:07 am - 1:38 am
CHS
-
SDQ
17h 31m
1 stop
$406Spirit Airlines
Mon, Mar 16 - Tue, Apr 7
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
Spirit Airlines Logo
8:07 am - 1:38 am
CHS
-
SDQ
17h 31m
1 stop
$412Spirit Airlines
Wed, Mar 18 - Tue, Apr 7
American Airlines Logo
6:00 am - 11:59 pm
SDQ
-
CHS
17h 59m
1 stop
American Airlines Logo
8:08 pm - 9:20 am
CHS
-
SDQ
13h 12m
1 stop
$423American Airlines
Wed, Mar 18 - Mon, Apr 6
Spirit Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
Spirit Airlines Logo
8:07 am - 1:38 am
CHS
-
SDQ
17h 31m
1 stop
$426Spirit Airlines
Thu, Mar 19 - Tue, Apr 7
Multiple Airlines Logo
2:52 am - 10:13 pm
SDQ
-
CHS
19h 21m
1 stop
Multiple Airlines Logo
12:04 pm - 1:56 pm
CHS
-
SDQ
25h 52m
2 stops
$427Multiple Airlines
Mon, Mar 16 - Tue, Apr 7
Multiple Airlines Logo
2:20 pm - 10:13 pm
SDQ
-
CHS
7h 53m
1 stop
Multiple Airlines Logo
12:04 pm - 1:56 pm
CHS
-
SDQ
25h 52m
2 stops
$433Multiple Airlines
Wed, Mar 18 - Tue, Apr 7

American Airlines flights from Santo Domingo to Charleston

Our best American Airlines deals on Santo Domingo to Charleston flight tickets
American Airlines
Apr 29
SDQ5:55 pmSanto Domingo Las Americas
6h 29m
1 stop
CHS12:24 amCharleston
May 17
CHS8:09 pmCharleston
13h 11m
1 stop
SDQ9:20 amSanto Domingo Las Americas
$357
American Airlines
Jul 27
SDQ7:38 pmSanto Domingo Las Americas
14h 35m
1 stop
CHS10:13 amCharleston
Aug 18
CHS5:50 amCharleston
9h 35m
1 stop
SDQ3:25 pmSanto Domingo Las Americas
$366
American Airlines
May 14
SDQ5:55 pmSanto Domingo Las Americas
16h 39m
1 stop
CHS10:34 amCharleston
Sep 15
CHS8:43 pmCharleston
14h 12m
2 stops
SDQ10:55 amSanto Domingo Las Americas
$369

JetBlue flights from Santo Domingo to Charleston

Our best JetBlue deals on Santo Domingo to Charleston flight tickets
JetBlue
May 9
SDQ5:50 amSanto Domingo Las Americas
11h 07m
1 stop
CHS4:57 pmCharleston
May 10
CHS8:08 pmCharleston
18h 34m
2 stops
SDQ2:42 pmSanto Domingo Las Americas
$560
JetBlue
Apr 28
SDQ3:05 amSanto Domingo Las Americas
16h 12m
2 stops
CHS7:17 pmCharleston
May 17
CHS11:00 amCharleston
9h 56m
2 stops
SDQ8:56 pmSanto Domingo Las Americas
$652
JetBlue
May 9
SDQ5:50 amSanto Domingo Las Americas
13h 23m
2 stops
CHS7:13 pmCharleston
May 10
CHS8:08 pmCharleston
24h 48m
2 stops
SDQ8:56 pmSanto Domingo Las Americas
$758

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 1, 2026.
Use the filters below to find and compare flights from Santo Domingo to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 4/29

5:55 pm-12:24 am

1 stop6h 29m

Charleston

Sun 5/17

8:09 pm-9:20 am

1 stop13h 11m

$357

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 7/27

7:38 pm-10:13 am

1 stop14h 35m

Charleston

Tue 8/18

5:50 am-3:25 pm

1 stop9h 35m

$366

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 5/14

5:55 pm-10:34 am

1 stop16h 39m

Charleston

Tue 9/15

8:43 pm-10:55 am

2 stops14h 12m

$369

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 7/27

7:38 pm-10:13 am

1 stop14h 35m

Charleston

Tue 8/18

6:50 am-6:20 pm

2 stops11h 30m

$370

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 3/16

2:52 am-10:13 pm

1 stop19h 21m

Charleston

Tue 4/7

8:07 am-1:38 am

1 stop17h 31m

$406

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 3/18

2:20 pm-10:13 pm

1 stop7h 53m

Charleston

Tue 4/7

8:07 am-1:38 am

1 stop17h 31m

$412

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 3/18

6:00 am-11:59 pm

1 stop17h 59m

Charleston

Mon 4/6

8:08 pm-9:20 am

1 stop13h 12m

$423

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 3/19

2:20 pm-10:13 pm

1 stop7h 53m

Charleston

Tue 4/7

8:07 am-1:38 am

1 stop17h 31m

$426

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 3/16

2:52 am-10:13 pm

1 stop19h 21m

Charleston

Tue 4/7

12:04 pm-1:56 pm

2 stops25h 52m

$427

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 3/18

2:20 pm-10:13 pm

1 stop7h 53m

Charleston

Tue 4/7

12:04 pm-1:56 pm

2 stops25h 52m

$433

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santo Domingo to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santo Domingo and Charleston?

When to book flights from Santo Domingo to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Charleston (SDQ to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Charleston

Fastest flight time

6h 05m

Direct flights

None
The fastest flight from Santo Domingo to Charleston takes 6h 05m
There are no direct flights from Santo Domingo to Charleston. There are no popular flight routes from Santo Domingo to Charleston.
Search flight deals

  • How far is Santo Domingo Las Americas to Charleston by plane?

    A flight from Santo Domingo Las Americas to Charleston will travel around 1165.2 mi. Flights usually cover this in 6h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Charleston Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Charleston Airport refresh daily.

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Charleston Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santo Domingo Las Americas Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Charleston?

It is quick and easy to find Santo Domingo to Charleston flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Charleston that suits you.

Can I find flights from Santo Domingo to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santo Domingo to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Santo Domingo to Charleston?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Charleston from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Santo Domingo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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