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Cheap flights from Santo Domingo to Charleston from $187

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to Charleston departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Santo Domingo to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:55 am - 10:42 pm
SDQ
-
CHS
14h 47m1 stop
American Airlines Logo
11:17 am - 9:50 pm
CHS
-
SDQ
10h 33m1 stop
$344American Airlines
Fri, May 1 - Mon, May 4
United Airlines Logo
2:53 pm - 11:44 pm
SDQ
-
CHS
9h 51m1 stop
United Airlines Logo
6:00 am - 3:06 pm
CHS
-
SDQ
8h 06m1 stop
$418United Airlines
Thu, Jan 29 - Mon, Feb 2
JetBlue Logo
9:50 pm - 9:20 am
SDQ
-
CHS
12h 30m1 stop
JetBlue Logo
1:10 pm - 4:34 am
CHS
-
SDQ
14h 24m1 stop
$444JetBlue
Wed, Feb 4 - Sat, Feb 7
American Airlines Logo
1:28 pm - 11:28 pm
SDQ
-
CHS
10h 00m2 stops
American Airlines Logo
8:08 pm - 10:50 am
CHS
-
SDQ
14h 42m1 stop
$455American Airlines
Fri, May 1 - Mon, May 4
American Airlines Logo
5:55 am - 5:15 pm
SDQ
-
CHS
11h 20m2 stops
American Airlines Logo
5:32 am - 12:35 pm
CHS
-
SDQ
7h 03m2 stops
$561American Airlines
Fri, May 1 - Mon, May 4

American Airlines flights from Santo Domingo to Charleston

Our best American Airlines deals on Santo Domingo to Charleston flight tickets
American Airlines
May 1
SDQ7:55 amSanto Domingo Las Americas
14h 47m
1 stop
CHS10:42 pmCharleston
May 4
CHS11:17 amCharleston
10h 33m
1 stop
SDQ9:50 pmSanto Domingo Las Americas
$344
Find similar
American Airlines
May 1
SDQ1:28 pmSanto Domingo Las Americas
10h 00m
2 stops
CHS11:28 pmCharleston
May 4
CHS8:08 pmCharleston
14h 42m
1 stop
SDQ10:50 amSanto Domingo Las Americas
$455
Find similar
American Airlines
May 1
SDQ5:55 amSanto Domingo Las Americas
11h 20m
2 stops
CHS5:15 pmCharleston
May 4
CHS5:32 amCharleston
7h 03m
2 stops
SDQ12:35 pmSanto Domingo Las Americas
$561
Find similar

Spirit Airlines flights from Santo Domingo to Charleston

Our best Spirit Airlines deals on Santo Domingo to Charleston flight tickets
Spirit Airlines
Dec 28
SDQ3:59 amSanto Domingo Las Americas
18h 24m
1 stop
CHS9:23 pmCharleston
Jan 22
CHS6:35 pmCharleston
18h 52m
1 stop
SDQ2:27 pmSanto Domingo Las Americas
$329
Find similar
Spirit Airlines
Dec 28
SDQ3:59 amSanto Domingo Las Americas
18h 24m
1 stop
CHS9:23 pmCharleston
Jan 22
CHS5:05 pmCharleston
20h 22m
2 stops
SDQ2:27 pmSanto Domingo Las Americas
$390
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Santo Domingo to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

7:55 am-10:42 pm

1 stop14h 47m

Charleston

Mon 5/4

11:17 am-9:50 pm

1 stop10h 33m

$344

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 1/29

2:53 pm-11:44 pm

1 stop9h 51m

Charleston

Mon 2/2

6:00 am-3:06 pm

1 stop8h 06m

$418

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 2/4

9:50 pm-9:20 am

1 stop12h 30m

Charleston

Sat 2/7

1:10 pm-4:34 am

1 stop14h 24m

$444

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

1:28 pm-11:28 pm

2 stops10h 00m

Charleston

Mon 5/4

8:08 pm-10:50 am

1 stop14h 42m

$455

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

5:55 am-5:15 pm

2 stops11h 20m

Charleston

Mon 5/4

5:32 am-12:35 pm

2 stops7h 03m

$561

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 5/27

11:30 am-5:12 pm

1 stop5h 42m

$187

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Wed 5/27

6:30 pm-12:13 am

1 stop5h 43m

$188

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Mon 12/29

4:49 pm-8:47 am

1 stop16h 58m

$194

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sat 3/14

7:50 pm-8:32 am

1 stop12h 42m

$208

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sat 3/14

7:50 pm-8:32 am

1 stop12h 42m

$231

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Santo Domingo to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Santo Domingo to Charleston is on a Thursday. Travelers who choose to depart for Charleston on a Thursday will often find tickets for as low as $344. The most expensive day to fly to Charleston is Tuesday, with ticket prices averaging around $542.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the evening when flights can be purchased for as low as $365. In the morning is when there is more demand to fly to Charleston, so prices are often more expensive at around $542 per ticket.

When to book flights from Santo Domingo to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Santo Domingo to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santo Domingo to Charleston (SDQ to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to Charleston

Fastest flight time

6h 02m

Direct flights

None
The fastest flight from Santo Domingo to Charleston takes 6h 02m
There are no direct flights from Santo Domingo to Charleston. There are no popular flight routes from Santo Domingo to Charleston.
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  • How far is Santo Domingo Las Americas to Charleston by plane?

    A flight from Santo Domingo Las Americas to Charleston will travel around 1165.2 mi. Flights usually cover this in 6h 02m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to Charleston Airport?

    Prices for flights from Santo Domingo Las Americas Airport to Charleston Airport refresh daily.

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to Charleston Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santo Domingo Las Americas Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to Charleston?

It is quick and easy to find Santo Domingo to Charleston flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Charleston that suits you.

Can I find flights from Santo Domingo to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santo Domingo to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Santo Domingo to Charleston?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Charleston from Santo Domingo.

I’m not ready to book a flight from Santo Domingo to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Santo Domingo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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